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Andrologia

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https://www.readbyqxmd.com/read/29235139/association-of-serum-testosterone-levels-and-testicular-volume-in-adult-patients
#1
S F Ruiz-Olvera, O Rajmil, J-R Sanchez-Curbelo, J Vinay, J Rodriguez-Espinosa, E Ruiz-Castañé
A retrospective observational study was undertaken to gain new insight into the relationship between total testicular volume and levels of serum testosterone, luteinising hormone, follicle-stimulating hormone, prolactin and clinical variables. A total of 312 men with sexual dysfunction or infertility were divided into groups A and B (156 each) on the basis of basal plasma testosterone ≤5 nmol/L of ≥12 nmol/L respectively. Group A was subclassified in A1 (primary hypogonadism) and A2 (secondary hypogonadism)...
December 12, 2017: Andrologia
https://www.readbyqxmd.com/read/29230854/adjuvant-potential-of-virgin-coconut-oil-extract-on-antiretroviral-therapy-induced-testicular-toxicity-an-ultrastructural-study
#2
O O Ogedengbe, A I Jegede, I O Onanuga, U Offor, A I Peter, E N Akang, E C S Naidu, O O Azu
The effects of Virgin coconut oil as an adjuvant to highly active antiretroviral therapy (HAART) were investigated on the testicular ultrastructure and biochemical markers in rats. Twenty male Sprague-Dawley rats, weighing 153-169 g were divided into four groups and treated as follows: control A (distilled water), B (HAART), C (HAART+Virgin coconut oil 10 ml/kg) and D (Virgin coconut oil [VCO] 10 ml/kg). Testicular segments were evaluated using transmission electron microscopy. Serum was assayed for testosterone, luteinising hormone, follicle stimulating hormone and testicular tissue for malondialdehyde and glutathione...
December 12, 2017: Andrologia
https://www.readbyqxmd.com/read/29230840/correlation-of-biochemical-constituents-of-seminal-plasma-with-semen-quality-in-teddy-goat-capra-hircus-bucks
#3
S Umar, M Ahmad, I Ahmad, M Zubair, Z Umar, A S Qureshi, A Manzoor, A Murtaza, A Shaukat
This study was planned to determine the relationship between semen quality parameters and the levels of biochemical constituents of seminal plasma of Teddy (Capra hircus) buck semen. For this purpose, semen ejaculates were collected from five mature healthy Teddy bucks. All the experimental bucks were kept under natural environmental conditions. Semen was collected twice in a week for the duration of 6 weeks by Artificial Vagina (AV) in the breeding season (February-April). Two successive ejaculates of single buck were pooled at time of collection, and a total of 60 semen samples were processed for semen analysis...
December 12, 2017: Andrologia
https://www.readbyqxmd.com/read/29230838/carnosine-prevents-testicular-oxidative-stress-and-advanced-glycation-end-product-formation-in-d-galactose-induced-aged-rats
#4
A F Aydın, C Küçükgergin, J Çoban, I Doğan-Ekici, S Doğru-Abbasoğlu, M Uysal, N Koçak-Toker
D-Galactose is shown to mimic natural ageing in rodents by exacerbating oxidative stress and glycation. Steroid production and having a poor antioxidant system make testis vulnerable to galactose-induced ageing. Antioxidation and antiglycating actions of carnosine may be intriguing for prevention of testicular ageing. In this study, male Wistar rats were applied D-galactose (300 mg/kg; subcutaneously 5 days a week) and carnosine (250 mg/kg; intraperitoneally 5 days a week) along with D-galactose for 2 months...
December 12, 2017: Andrologia
https://www.readbyqxmd.com/read/29230837/alterations-in-dna-methylation-patterns-and-gene-expression-in-spermatozoa-of-subfertile-males
#5
M Laqqan, M E Hammadeh
This study was designed to evaluate the DNA methylation patterns and gene expression in spermatozoa from subfertile males. Thirty samples were subjected to 450K arrays as a screening study to evaluate the variation in sperm DNA methylation levels between cases and controls groups, and then three CpG sites (cg07227024, cg05813498 and cg23081194) have the highest difference in methylation levels and located within ALS2CR12, GAA and UBE2G2 genes respectively; these were selected for further analysis using deep bisulphite sequencing and qPCR in 136 samples (64 proven fertile males "controls" and 72 subfertile males "cases")...
December 12, 2017: Andrologia
https://www.readbyqxmd.com/read/29205874/establishment-of-experimental-autoimmune-prostatitis-model-by-t2-peptide-in-aluminium-hydroxide-adjuvant
#6
L Zhang, A U Ihsan, Y Cao, Y Cheng, X Zhou
A mouse model was developed to simulate the clinical features of chronic prostatitis/chronic pelvic pain syndrome using peptide (T2 ). Forty C57BL/6 mice were divided into four groups of 10 mice each, averagely and randomly. T2 plus aluminium hydroxide adjuvant group was given subcutaneous injection with the emulsion mixture of T2 and aluminium hydroxide adjuvant, the T2 group with T2 , the aluminium hydroxide adjuvant group with aluminium hydroxide adjuvant and the normal control group with 0.9/% NaCl solution...
December 4, 2017: Andrologia
https://www.readbyqxmd.com/read/29205438/towards-the-identification-of-reliable-sperm-biomarkers-for-male-infertility-a-sperm-proteomic-approach
#7
P Intasqui, A Agarwal, R Sharma, L Samanta, R P Bertolla
Male infertility evaluation is mainly based on semen analysis. Thus, identification of additional diagnostic methods is valuable. The aim of this study was to analyse the sperm proteome of infertile men to identify the underlying mechanisms and reliable diagnostic biomarkers. This cross-sectional study consisted of 16 infertile men and seven proven fertile men. An LC-MS/MS approach was performed in five pooled samples of each group (proven fertile men, primary infertility and secondary infertility). Differentially expressed proteins were used for functional enrichment analyses, and the most central proteins involved in altered functions in both infertile groups and the testis-specific proteins were validated using Western blotting and immunocytochemistry...
December 4, 2017: Andrologia
https://www.readbyqxmd.com/read/29164711/vitamin-e-improves-testicular-damage-in-streptozocin-induced-diabetic-rats-via-increasing-vascular-endothelial-growth-factor-and-poly-adp-ribose-polymerase-1
#8
S S Omar, R G Aly, N M Badae
The precise mechanism by which diabetes impairs spermatogenesis and testicular function is not exactly known. Vascular endothelial growth factor (VEGF) and poly(ADP-ribose) polymerase-1 (PARP-1) are important for germ cell homeostasis and repair of DNA respectively. The aim of this study was to investigate the correlation between diabetes-induced testicular damage and testicular VEGF and PARP-1 expression and the possible protective role of vitamin E supplementation. A total of 45 male Wistar albino rats were randomly divided into three groups: Group I (nondiabetic rats), Group II (streptozocin-induced diabetic rats) and Group III (streptozocin-induced diabetic rats treated orally with 0...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29164653/gradient-sperm-selection-for-reproductive-techniques-in-cattle-is-isolate-a-suitable-replacement-for-percoll
#9
B Sepúlveda, M E Arias, L Aguila, F Zambrano, R Sánchez, R Felmer
In assisted reproductive techniques, it is essential to perform a sperm selection to obtain spermatozoa with high motility and membrane integrity for in vitro fertilisation (IVF) and high-DNA integrity for intracytoplasmic sperm injection (ICSI). In this study, we evaluated whether Isolate(®) was a suitable substitute for Percoll(®) for assisted reproductive techniques. Commercial cryopreserved bovine semen was used after selection in both gradients, and plasma and acrosome membrane integrity, reactive oxygen species (ROS) levels, DNA integrity and mitochondrial membrane potential (ΔΨm) were assessed by flow cytometry...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29164652/cerium-oxide-nanoparticle-elicits-oxidative-stress-endocrine-imbalance-and-lowers-sperm-characteristics-in-testes-of-balb-c-mice
#10
O A Adebayo, O Akinloye, O A Adaramoye
The toxicity of metallic nanoparticles is a growing concern due to its application in industries and homes. We investigated the toxicity of cerium oxide nanoparticles (CeO2 NPs) on reproductive system in male balb/c mice. Twenty mice were divided into four groups of five animals each and treated thus: normal saline (control), 100, 200 and 300 μg/kg CeO2 NPs (i.p.,) thrice in a week for five consecutive weeks. Results showed that CeO2 NPs significantly reduced the levels of haemoglobin, PCV and RBC count relative to controls...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29164649/impact-of-alcohol-and-cigarette-smoking-consumption-in-male-fertility-potential-looks-at-lipid-peroxidation-enzymatic-antioxidant-activities-and-sperm-dna-damage
#11
S Aboulmaouahib, A Madkour, I Kaarouch, O Sefrioui, B Saadani, H Copin, M Benkhalifa, N Louanjli, R Cadi
Alcohol intake and cigarette smoking are the major lifestyle factors with negative impact on fertility. We were interested to evaluate the negative impact of these factors on oxidative stress (OS), enzymatic antioxidant activity (EAO) of spermatozoa and on its DNA damage. This study included 108 male infertile patients with normal range of sperm conventional parameters but with unexplained infertility in assisted reproductive technologies programme. Firstly, OS was analysed based on lipid peroxidation (MDA) and EAO which included catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR)...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29160562/aqueous-extract-of-yellow-maca-lepidium-meyenii-improves-sperm-count-in-experimental-animals-but-response-depends-on-hypocotyl-size-ph-and-routes-of-administration
#12
L Sanchez-Salazar, G F Gonzales
Lepidium meyenii, a Peruvian plant growing over 4000 m.a.s.l., has effects on nutrition and fertility. The purpose of this study was to evaluate the sperm count in 105 male mice receiving boiled aqueous extract of yellow maca hypocotyls from different sizes, under different pH conditions and using two different routes of administration. Five mice per group were treated daily for 3 days with vehicle (oral and intraperitoneal) or maca aqueous extracts (5 mg/0.5 ml/day) belonging to the first, second, third and fourth categories, according to their hypocotyl size...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29159909/essential-role-of-brain-derived-neurotrophic-factor-bdnf-in-diabetic-erectile-dysfunction
#13
L Hu, S Qi, K Zhang, Q Fu
Erectile dysfunction (ED) is a worldwide problem threatens men's health. The incidence of ED in diabetic patients is higher than that in the healthy population. The incidence of peripheral and autonomic neuropathy is significantly higher in diabetic patients than in normal men. Vasomotor nerves play an important role in the regulation of erectile function. Degeneration of autonomic and sensory nerves is a common type of diabetic neuropathy (DNP) and is closely related to erectile function. Brain-derived neurotrophic factor (BDNF) has been demonstrated to improve diabetic erectile dysfunction in rat models and in humans...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29159832/expression-and-localisation-of-rxfp3-in-human-spermatozoa-and-impact-of-insl7-on-sperm-functions
#14
S Heidari, A H Taromchi, R Nejatbakhsh, S Shokri
Insulin-like peptide 7 (INSL7) or relaxin-3 is a member of the insulin superfamily that is recently discovered. This hormone interacts with relaxin family peptide receptor 3 (RXFP3). Although recent studies of INSL7 have focused on its function in the brain as a neuropeptide, spermatozoa may be a candidate target of INSL7 due to its detection in testes and contains binding sites. Therefore, this study aims to analyse the expression and localisation of RXFP3 on human spermatozoa and to assess the effect of INSL7 on human sperm motility...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29152782/oestradiol-17%C3%AE-is-a-local-factor-inducing-the-early-stage-of-spermatogenesis-in-mouse-testes
#15
K G Kim, Y S Park
This study was undertaken to elucidate the effect of testicular oestradiol-17β (E2 ) on spermatogenesis. Spermatogonial development and spermatogenic gene expression in testicular germ cells were investigated using an in vitro culture system supplemented with E2 . E2 stimulated spermatocytogenic development of cultured testicular germ cells regardless of the addition of follicle-stimulating hormone and testosterone to the culture medium. E2 also induced the expression of genes encoding synaptonemal complex protein 1 and protamine 1, proteins required for spermatogenesis...
November 20, 2017: Andrologia
https://www.readbyqxmd.com/read/29143963/expression-of-paraoxonase-types-1-2-and-3-in-reproductive-tissues-and-activity-of-paraoxonase-type-1-in-the-serum-and-seminal-plasma-of-bulls
#16
C E R Ferreira, C S Haas, K L Goularte, M T Rovani, F F Cardoso, A Schneider, B G Gasperin, T Lucia
The paraoxonases types 1, 2 and 3 (PON1, PON2 and PON3, respectively) are enzymes that degrade lipid peroxides, preventing oxidative damages relevant for male reproductive function. This study determined the expression of those three paraoxonases in reproductive tissues of bulls and evaluated correlations among the activity of PON1 in the serum and seminal plasma with breeding soundness parameters in bulls. The expression of PON1, PON2 and PON3 was characterised by RT-PCR in samples of testicular parenchyma, vesicular glands and epididymis collected from three slaughtered bulls...
November 16, 2017: Andrologia
https://www.readbyqxmd.com/read/29124782/the-effect-of-cigarette-smoking-on-human-seminal-parameters-sperm-chromatin-structure-and-condensation
#17
R M Mostafa, Y S Nasrallah, M M Hassan, A F Farrag, A Majzoub, A Agarwal
Considerable debate still exists regarding the effects of cigarette smoking on male fertility. This work aimed to explore effects of cigarette smoking on semen parameters and DNA fragmentation on 95 infertile patients who were divided into infertile male nonsmokers (45) and infertile male smokers (50). Smokers were subdivided according to a number of cigarettes smoked per day into mild (≤10), moderate (11-20) and heavy smokers (≥21). Semen analysis, sperm chromatin condensation integrity with aniline blue staining and sperm viability were compared between the study groups...
November 9, 2017: Andrologia
https://www.readbyqxmd.com/read/29110321/effect-of-nordihydroguaiaretic-acid-on-spermatogenesis-and-fertility-in-rats
#18
M A Abbas, D Badran, A Disi
Nordihydroguaiaretic acid (NDGA) is a naturally occurring lignan with potent antioxidant activity. Currently, it is in clinical trials as anticancer agent. As there is no earlier report on the effect of NDGA on spermatogenesis and fertility, this study was designed to investigate this aspect. Administration of NDGA to rats for 60 days produced degenerative changes in testis but had no effect on sperm DNA integrity test and androgen receptor expression. Ultrastructural studies revealed loss of integrity of cells in seminiferous tubules, vacuolation and presence of apoptotic bodies...
November 6, 2017: Andrologia
https://www.readbyqxmd.com/read/29110319/effects-of-chlamydia-trachomatis-infection-on-sperm-chromatin-condensation-and-dna-integrity
#19
L Dehghan Marvast, A R Talebi, J Ghasemzadeh, A Hosseini, A A Pacey
The present study was performed to investigate the relation of Chlamydia trachomatis infection to sperm chromatin/DNA integrity in a population of infertile men (male partner of infertile couples) from Iran. Blood, semen and first-void urine samples were obtained from 250 infertile men. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to C. trachomatis in serum; (ii) the presence of C. trachomatis and DNA in first-void urine; and (iii) in the semen sample of the male partner, in addition to sperm analysis, four different tests (aniline blue, chromomycin A3, acridine orange and TUNEL) were used to detect sperm chromatin and DNA abnormalities...
November 6, 2017: Andrologia
https://www.readbyqxmd.com/read/29110315/nad-p-h-quinone-oxidoreductase-1-silencing-aggravates-hormone-induced-prostatic-hyperplasia-in-mice
#20
H-T Kim, Y-J Kim, S-R Park, S-Y Ryu, J-Y Jung
NAD(P)H-quinone oxidoreductase 1 (NQO1) is a highly inducible flavoprotein known to involve in various cellular defence mechanisms. In this study, we explored whether NQO1 deletion affects hormone-induced prostatic hyperplasia. Testosterone propionate (3 mg/kg, IP) was injected into wild-type (WT) and NOQ1 knockout C57BL/6 mice (NQO1(-/-) ) for 14 consecutive days, and the samples were collected for biological and histochemical studies. The testosterone-treated NQO1(-/-) showed about 140% higher prostate weight than the testosterone-treated WT, with enhanced connective tissue and hyperplastic glands formations...
November 6, 2017: Andrologia
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