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Andrologia

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https://www.readbyqxmd.com/read/28421619/molecular-detection-of-chlamydia-trachomatis-and-semen-quality-of-sexual-partners-of-infertile-women
#1
M López-Hurtado, M Velazco-Fernández, M J E Pedraza-Sánchez, V R Flores-Salazar, R Villagrana Zesati, F M Guerra-Infante
Chlamydia trachomatis is considered as the bacterium that is more sexually transmitted as cause of male urethritis, epididymitis, orchitis and infertility. A total of 116 semen samples of men whose couples are infertile women were analysed. The quality of the semen was measured by standard procedures recommended by WHO while C. trachomatis was detected by the PCR assay. Thirty-seven semen samples were positive for C. trachomatis (31.9%). Regarding semen analysis, no different values were observed between positive and negative samples to C...
April 19, 2017: Andrologia
https://www.readbyqxmd.com/read/28378913/efficacy-of-varicocelectomy-in-the-treatment-of-hypogonadism-in-subfertile-males-with-clinical-varicocele-a-meta-analysis
#2
X Chen, D Yang, G Lin, J Bao, J Wang, W Tan
To reassess the efficacy of varicocelectomy in the treatment of hypogonadism in subfertile males, we carried out a meta-analysis of clinical trials and retrospective studies that compared the pre-operative and postoperative serum testosterone. We searched Embase and PubMed (1980 to May 2016) for studies. Eight studies and 712 patients were included. The combined analysis of seven studies discovered that the mean serum testosterone of patients post-operation improved by 34.3 ng/dl (95% CI: 22.57-46.04, p < ...
April 5, 2017: Andrologia
https://www.readbyqxmd.com/read/28370226/total-flavonoids-of-epimedium-reduce-ageing-related-oxidative-dna-damage-in-testis-of-rats-via-p53-dependent-pathway
#3
H Zhao, L Song, W Huang, J Liu, D Yuan, Y Wang, C Zhang
Increased DNA damage in testis is considered as a major factor for ageing-related dysfunction. Total flavonoids of Epimedium (TFE), the main active compositions of Epimedium, have been used to treat sexual dysfunction and delay ageing. However, whether TFE could improve ageing-related testicular dysfunction remains unknown. Therefore, we investigated the protection effects of TFE and its mechanisms of action in a naturally ageing rat model. Eighteen-month-old SD rats were randomised to receive either vehicle or TFE (10 and 20 mg/kg)...
March 30, 2017: Andrologia
https://www.readbyqxmd.com/read/28370107/association-of-the-c-9c-t-and-c-368a-g-transitions-in-h2bfwt-gene-with-male-infertility-in-an-iranian-population
#4
A Rafatmanesh, H Nikzad, A Ebrahimi, M Karimian, T Zamani
The H2BFWT (H2B family, member W, testis specific) gene is a testis-specific histone which is involved in the spermatogenesis process. This study aimed to investigate the association of H2BFWT gene c.-9C>T and c.368A>G polymorphisms with male infertility in an Iranian population. The 232 independent individuals, including 109 infertile men and 123 healthy controls, were recruited from IVF centre (Kashan, Iran). The allele types of c.-9C>T and c.368A>G polymorphisms were detected by using PCR-RFLP method...
March 30, 2017: Andrologia
https://www.readbyqxmd.com/read/28370451/honey-improves-spermatogenesis-and-hormone-secretion-in-testicular-ischaemia-reperfusion-induced-injury-in-rats
#5
M Gholami, A Abbaszadeh, Z Khanipour Khayat, K Anbari, P Baharvand, A M Gharravi
This study was conducted to survey the protective effect of pre-treatment with Persian honey during post-ischaemia reperfusion on ischaemia-reperfusion (IR)-induced testis injury. Animals were divided into four groups of IR, honey + ischaemia- reperfusion (HIR), vitamin C + ischaemia- reperfusion (VIR) and carbohydrates + ischaemia- reperfusion (CIR). The testes were examined for spermatogenesis index. Detection of single- and double-stranded DNA breaks at the early stages of apoptosis was performed. Total serum concentration of FSH, LH and testosterone was measured using ELISA...
March 28, 2017: Andrologia
https://www.readbyqxmd.com/read/28295512/fertility-enhancing-activity-and-toxicity-profile-of-aqueous-extract-of-chasmanthera-dependens-roots-in-male-rats
#6
A L Quadri, M T Yakubu
This study evaluated the fertility-enhancing activity and safety of aqueous extract of Chasmanthera dependens root (AECDR) in male rats. In the fertility study, twenty, sodium arsenite (10 mg/kg) body weight (BW)-treated male rats (171.02 ± 3.36 g), assigned into four groups (I-IV), received 1 ml of distilled water (DW), 25, 50 and 100 mg/kg BW of AECDR for 60 days, whereas the control received DW. After 7 days of pairing with female rats (153.67 ± 2.24 g), spermatogenic, fertility, testicular function indices and enzymatic antioxidant activities were evaluated...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28295500/sperm-dna-methylation-of-h19-imprinted-gene-and-male-infertility
#7
F Nasri, B Gharesi-Fard, B Namavar Jahromi, M A Farazi-Fard, M Banaei, M Davari, S Ebrahimi, Z Anvar
Infertility affects up to 15% of reproductive-aged couples worldwide, with male factor being detected in 40%-50% of the cases. Proper sperm production is associated with the establishment of appropriate epigenetic marks in developing germ cells. Several studies have demonstrated the association between abnormal spermatogenesis and epigenetic disturbances with the major focus on DNA methylation. Imprinted genes are expressed in a parent-of-origin-specific manner, and the role of their DNA methylation in proper spermatogenesis has been documented recently...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28295487/sperm-dna-fragmentation-as-a-result-of-ultra-endurance-exercise-training-in-male-athletes
#8
D Vaamonde, C Algar-Santacruz, A Abbasi, J M García-Manso
Intensive sports practice seems to exert negative effects on semen parameters; in order to assess these effects, the objective of this study was to assess semen, including DNA fragmentation, and hormone parameters in elite triathletes. Twelve high-level triathletes preparing for a National Triathlon Championship participated in the study. The qualitative sperm parameters analysed were volume, sperm count, motility, morphology and DNA fragmentation; when needed, additional testing was performed. Assessed hormones were testosterone (T), cortisol (C) and testosterone-cortisol ratio (T/C)...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28295481/effects-of-taking-tadalafil-5%C3%A2-mg-once-daily-on-erectile-function-and-total-testosterone-levels-in-patients-with-metabolic-syndrome
#9
L Ozcan, E C Polat, R Kocaaslan, E Onen, A Otunctemur, E Ozbek
We aimed to evaluate the efficacy of tadalafil 5 mg once-daily treatment on testosterone levels in patients with erectile dysfunction (ED) accompanied by the metabolic syndrome. A total of 40 men with metabolic syndrome were evaluated for ED in this study. All the patients received 5 mg tadalafil once a day for 3 months. Erectile function was assessed using the five-item version of the International Index of Erectile Function (IIEF) questionnaire. Serum testosterone, follicle-stimulating hormone and luteinising hormone levels were also evaluated, and blood samples were taken between 08...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28295478/effects-of-various-cryoprotectants-on-the-quality-of-frozen-thawed-immature-bovine-qinchuan-cattle-calf-testicular-tissue
#10
X-G Zhang, H Li, J-H Hu
To investigate the effects of different concentrations of various cryoprotectants (CPs) on the cell viability as well as expression of spermatogenesis-related genes, such as CREM, Stra8 and HSP70-2 in frozen-thawed bovine calf testicular tissue, immature bovine (Qinchuan cattle) calf testicular tissue was collected and cryopreserved in the cryomedia containing different concentrations (5%, 10%, 15% and 20%) of the following three CPs: glycerol, ethylene glycol (EG) and dimethyl sulphoxide (DMSO) respectively...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28294377/cumene-hydroperoxide-induced-changes-in-oxidation-reduction-potential-in-fresh-and-frozen-seminal-ejaculates
#11
A Agarwal, R Sharma, R Henkel, S Roychoudhury, S C Sikka, S du Plessis, Y B Sarda, C Speyer, M Nouh, C Douglas, Z Kayali, E S Ahmed, E Sabanegh
Oxidation-reduction potential (ORP) is a newer integrated measure of the balance between total oxidants (reactive oxygen species-ROS) and reductants (antioxidants) that reflects oxidative stress in a biological system. This study measures ORP and evaluates the effect of exogenous induction of oxidative stress by cumene hydroperoxide (CH) on ORP in fresh and frozen semen using the MiOXSYS Analyzer. Semen samples from healthy donors (n = 20) were collected and evaluated for sperm parameters. All samples were then flash-frozen at -80°C...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28294371/icariin-improves-the-sexual-function-of-male-mice-through-the-pi3k-akt-enos-no-signalling-pathway
#12
J Ding, Y Tang, Z Tang, X Zu, L Qi, X Zhang, G Wang
We aimed to investigate the effect and mechanism of icariin on male sexual function. Forty-eight Crl:CD1(ICR) male mice were randomly divided into control, low-, medium- and high-dose icariin group (intragastric administration of 50, 100 and 200 mg/kg/d for 21 days). Mating experiment was then performed at a ratio of 1: 3 (male: female). The mating behaviours of male mice were recorded. The genital indexes and serum testosterone, nitric oxide (NO), hypothalamic dopamine (DA) and 5- hydroxy tryptophan (5-HT) concentrations were measured...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28295520/androgen-deficiency-impairs-erectile-function-in-rats-through-promotion-of-corporal-fibrosis
#13
K Cui, R Li, R Chen, M Li, T Wang, J Yang, Z Chen, S Wang, J Liu, K Rao
The aim of this study was to investigate the underlying mechanism of androgen deficiency inducing corporal fibrosis, thereby causing erectile dysfunction (ED). Forty 12-week-old healthy male rats were divided randomly into four groups: normal control group (Control); castration group (Castration); the other 20 rats were castrated followed by testosterone (T) (orally) each day: castration + 10mg/kg T group (Castration + 10T) and castration + 20 mg/kg T group (Castration + 20T). After 8 weeks' treatment, the main outcome measures were the following: serum levels of T; the ratios of intracavernous pressure (ICP) to mean arterial pressure (MAP); histologic changes in penile smooth muscle cells; the Smad and non-Smad pathways; and extracellular matrix (ECM) protein deposition...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295519/single-nucleotide-polymorphisms-associated-with-nonsyndromic-cryptorchidism-in-mexican-patients
#14
M Chávez-Saldaña, R M Vigueras-Villaseñor, E Yokoyama-Rebollar, D A Landero-Huerta, J C Rojas-Castañeda, L Taja-Chayeb, J O Cuevas-Alpuche, E Zambrano
Cryptorchidism is a frequent genitourinary malformation considered as an important risk factor for infertility and testicular malignancy. The aetiology of cryptorchidism is multifactorial in which certain SNPs, capable of inhibiting the development of the gubernaculum, are implicated. We analysed 16 SNPs by allelic discrimination and automated sequencing in 85 patients and 99 healthy people, with the objective to identify the association between these variants and isolated cryptorchidism. In two different patients with unilateral cryptorchidism, we found the variants rs121912556 and p...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295504/testosterone-therapy-has-positive-effects-on-anthropometric-measures-metabolic-syndrome-components-obesity-lipid-profile-diabetes-mellitus-control-blood-indices-liver-enzymes-and-prostate-health-indicators-in-elderly-hypogonadal-men
#15
O Canguven, R A Talib, W El Ansari, D-J Yassin, M Salman, A Al-Ansari
To alleviate late-onset hypogonadism, testosterone treatment is offered to suitable patients. Although testosterone treatment is commonly given to late-onset hypogonadism patients, there remains uncertainty about the metabolic effects during follow-ups. We assessed the associations between testosterone treatment and wide range of characteristics that included hormonal, anthropometric, biochemical features. Patients received intramuscular 1,000 mg testosterone undecanoate for 1 year. Patient anthropometric measurements were undertaken at baseline and at each visit, and blood samples were drawn at each visit, prior to the next testosterone undecanoate...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295474/significant-predictive-factors-for-subfertility-in-patients-with-subclinical-varicocele
#16
S S-S Chen
We made a retrospective study to determine useful parameters for predicting subfertility in patients with subclinical varicocele (SV). One hundred and fifty men with SV and 17 age-matched men without SV were divided into three groups: Group 1, subfertile patients (n = 15); Group 2, fertile patients (n = 135); and Group 3, control patients (n = 17). Their age, body mass index (BMI), semen analysis, scrotal temperature, testicular volume, resistive index (RI), pulsatility index (PI) and peak retrograde flow (PRF) were compared...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295471/long-term-feeding-of-hydroalcoholic-extract-powder-of-lepidium-meyenii-maca-enhances-the-steroidogenic-ability-of-leydig-cells-to-alleviate-its-decline-with-ageing-in-male-rats
#17
K Yoshida, Y Ohta, N Kawate, M Takahashi, T Inaba, S Hatoya, H Morii, K Takahashi, M Ito, H Tamada
This study examined whether feeding hydroalcoholic extract of Lepidium meyenii (maca) to 8-week-old (sexually maturing) or 18-week-old (mature) male rats for more than a half year affects serum testosterone concentration and testosterone production by Leydig cells cultured with hCG, 22R-hydroxycholesterol or pregnenolone. Testosterone concentration was determined in the serum samples obtained before and 6, 12, 18 and 24 weeks after the feeding, and it was significantly increased only at the 6 weeks in the group fed with the maca extract to maturing rats when it was compared with controls...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295466/effect-of-kaempferia-parviflora-on-sexual-performance-in-streptozotocin-induced-diabetic-male-rats
#18
T Lert-Amornpat, C Maketon, W Fungfuang
Kaempferia parviflora Wall. Ex.Baker or Krachidum (KP) has been used locally in medicine and food. It has been claimed that KP has aphrodisia properties; however, no scientific data in support of this function in diabetic model have been reported. This study aimed to investigate the efficacy of KP on sexual behaviour and sperm parameter in streptozotocin (STZ)-induced diabetic male rats. Diabetes was induced in twenty male rats by STZ and divided into four groups: diabetic control group, and 3 treatment groups where KP was dose at 140, 280 and 420 mg/kg orally once a day for 6 weeks...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295462/ferulic-acid-prevents-lead-induced-testicular-oxidative-stress-and-suppressed-spermatogenesis-in-rats
#19
P Hasanein, F Fazeli, M Parviz, M Roghani
Lead affects multiple organ systems including testis. We investigated the effects of ferulic acid (FA) on lead-induced oxidative stress and spermatogenesis suppression in rats. Animals received lead acetate (500 mg/L in drinking water) and/or FA (50 mg/kg, i.g.) for eight weeks. Lead increased testicular malondialdehyde (MDA) and nitrite levels and decreased glutathione (GSH) content and catalase (CAT) activity. Lead decreased testis weight and testosterone level. Sperm parameters decreased in lead group...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295458/improvement-in-erectile-function-in-a-rat-model-of-high-cholesterol-diet-induced-atherosclerosis-by-atorvastatin-in-a-manner-that-is-independent-of-its-lipid-lowering-property
#20
Z Zhang, L Tang, W Yu, Y Chen, Y-T Dai
The purpose of the present study is to explore the effects of a lipid-lowering drug atorvastatin, a three-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in the treatment of erectile dysfunction (ED) in a rat model of atherosclerosis (AS) and the possible mechanisms underneath. A high-cholesterol diet was administrated to Sprague-Dawley rats in an attempt to induce an ASED model, which was later confirmed by abdominal aorta histopathology and erectile function evaluation. ASED rats were further assigned to non-treatment group, atorvastatin low-dose treatment group (5 mg kg(-1)  day(-1) ), high-dose group (10 mg kg(-1)  day(-1) ) and sildenafil (1...
March 10, 2017: Andrologia
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