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Andrologia

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https://www.readbyqxmd.com/read/29047156/cyclophosphamide-induced-male-subfertility-in-mice-an-assessment-of-the-potential-benefits-of-maca-supplement
#1
A Y Onaolapo, B P Oladipo, O J Onaolapo
Effects of Lepidium meyenii (Maca) on cyclophosphamide (CYP)-induced gonadal toxicity in male mice were investigated. Mice were assigned to six treatment groups: Vehicle control, CYP control, CYP plus oral Maca (500 or 1,000 mg/kg), and oral Maca (500 or 1,000 mg/kg). CYP was administered via the intraperitoneal route (days 1-2), while vehicle or Maca were administered daily for 28 days. On day 28, half of the animals in each group were either sacrificed or paired with age-matched females for fertility assessment...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/29047154/effects-of-testosterone-enanthate-and-resistance-training-on-myocardium-in-wistar-rats-clinical-and-anatomical-pathology
#2
S Karbasi, M Zaeemi, M Mohri, A Rashidlamir, Z Moosavi
This study was performed to determine the effects of 8 weeks testosterone enanthate (TE) injection and resistance training (RT) on cardiac muscle in male Wistar rats. A total of 28 male adult Wistar rats were randomly divided into 4 groups; control + placebo, RT + placebo, TE and TE + RT. Testosterone enanthate (20 mg/kg BW, IM) and placebo (olive oil; 0.2 ml, IM) were injected twice a week for 2 months. The RT consisted of climbing (5 reps/3 sets) a ladder carrying a load suspended from the tail...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/29044734/association-of-androgen-receptor-gene-cag-and-ggn-repeat-polymorphism-with-cryptorchidism-a-meta-analysis
#3
Qi Wang, Xing Ge, Heng-Xue Wang, Qiao-Mei Shi, Zhen Ding, Li-Chun Xu
Researches on association between variations in the androgen receptor (AR) gene repeat polymorphisms and cryptorchidism (CO) had conflicting results. The aim of this meta-analysis was to analyse the potential effects of AR CAG and/or GGN repeat polymorphism on CO. Studies were independently appraised by two investigators on PubMed, Web of Science, EBSCO databases and Foreign Medical Retrieval System. Case-control studies with measurement of CAG and/or GGN repeat length were included. Weighted mean difference (WMD) and 95% confidence intervals (CIs) for the CAG or GGN repeat polymorphism and CO were calculated...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/29044638/impact-of-melatonin-supplementation-in-the-rat-spermatogenesis-subjected-to-forced-swimming-exercise
#4
A Moayeri, T Mokhtari, A Hedayatpour, H-A Abbaszadeh, S Mohammadpour, H Ramezanikhah, S Shokri
Oxygen consumption increases many times during exercise, which can increase reactive oxygen species. It negatively affects fertility in male athletes. Melatonin is exerting a regulatory role at different levels of the hypothalamic-pituitary-gonadal axis. However, there is no evidence that the protective effects of melatonin persist after long duration exercise on the spermatogenesis. Therefore, this study was conducted to examine the impacts of melatonin on the testis following the administration of swimming exercise...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28983945/association-between-promoter-methylation-of-mlh1-and-msh2-and-reactive-oxygen-species-in-oligozoospermic-men-a-pilot-study
#5
S Gunes, A Agarwal, R Henkel, A M Mahmutoglu, R Sharma, S C Esteves, A Aljowair, D Emirzeoglu, A Alkhani, L Pelegrini, A Joumah, E Sabanegh
MLH1 and MSH2 are important genes for DNA mismatch repair and crossing over during meiosis and are implicated in male infertility. Therefore, the methylation patterns of the DNA mismatch repair genes MLH1 and MSH2 in oligozoospermic males were investigated. Ten oligozoospermic patients and 29 normozoospermic donors were analysed. Methylation profiles of the MLH1 and MSH2 promotors were analysed. In addition, sperm motility and seminal reactive oxygen species (ROS) were recorded. Receiver operating characteristic (ROC) analysis was conducted to determine the accuracy of the DNA methylation status of MLH1 and MSH2 to distinguish between oligozoospermic and normozoospermic men...
October 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28972266/infrared-thermography-as-a-noninvasive-method-to-assess-scrotal-insulation-on-sperm-production-in-beef-bulls
#6
S R O Menegassi, G R Pereira, E A Dias, M K Rocha, H R Carvalho, C Koetz, E R Oberst, J O J Barcellos
This study evaluated the thermoregulation and spermatogenic changes by scrotal temperature gradient using infrared thermography in testicular compromised bulls. Bulls were insulated (n = 6) for 72 hr and control animals (n = 3) remained without insulation during all the experimental period. Seminal evaluation was performed prior, at insult removal and once per week for 13 consecutive weeks. Mean temperature gradient in insulated animals was lower at the time of insulation removal compared to the week prior and after the insult (p < ...
October 3, 2017: Andrologia
https://www.readbyqxmd.com/read/28948696/benign-prostatic-hyperplasia-long-term-follow-up-of-prostate-volume-reduction-after-sclerotherapy-of-the-internal-spermatic-veins
#7
Y Gat, M Goren
The purpose was to examine the results of bilateral percutaneous sclerotherapy of the internal spermatic veins on prostate volume and prostatic symptoms. We previously showed that destruction of one-way valves in the internal spermatic veins (varicocele) elevates hydrostatic pressure in the vertical testicular venous drainage system in the erect human. This diverts free testosterone (FT) flow at high concentrations directly from the testes into the prostate. High intraprostatic FT prolongs prostate cell life and increases cell proliferation rate-synergistic effects resulting in increased cell population (BPH)...
September 25, 2017: Andrologia
https://www.readbyqxmd.com/read/28944567/differentiation-of-mesenchymal-stem-cells-to-germ-like-cells-under-induction-of-sertoli-cell-conditioned-medium-and-retinoic-acid
#8
R Ghaem Maghami, T Mirzapour, A Bayrami
The aim of this research was to find a way to differentiate germ cells from umbilical cord Wharton's jelly mesenchymal stem cells (MSCs) to support in vitro spermatogenesis. A small piece of Wharton's jelly was cultured in high-glucose Dulbecco's modified Eagle's medium in present of 10% foetal calf serum. After the fourth passage, the cells were isolated and cultured in Sertoli cell-conditioned medium under induction of two different doses of retinoic acid (10(-5) , 10(-6)  m). The differentiation of MSC to germ-like cells was evaluated by expression of Oct4, Nanog, Plzf, Stra8 and Prm1 genes during different days of culture through qPCR...
September 25, 2017: Andrologia
https://www.readbyqxmd.com/read/28929508/association-between-obesity-and-sperm-quality
#9
G A Ramaraju, S Teppala, K Prathigudupu, M Kalagara, S Thota, M Kota, R Cheemakurthi
There is awareness of likelihood of abnormal spermatozoa in obese men; however, results from previous studies are inconclusive. Advances in computer-aided sperm analysis (CASA) enable precise evaluation of sperm quality and include assessment of several parameters. We studied a retrospective cohort of 1285 men with CASA data from our infertility clinic during 2016. Obesity (BMI ≥30) was associated with lower (mean ± SE) volume (-0.28 ± 0.12, p-value = .04), sperm count (48.36 ± 16.51, p-value = ...
September 19, 2017: Andrologia
https://www.readbyqxmd.com/read/28901567/do-penile-haemodynamics-change-in-the-presence-of-hydrogen-sulphide-h2-s-donor-in-metabolic-syndrome-induced-erectile-dysfunction
#10
E Dayar, E Kara, G Yetik-Anacak, N Hocaoglu, O Bozkurt, S Gidener, N Durmus
Erectile dysfunction (ED) is defined in relation to the metabolic syndrome (metS). Hydrogen sulphide (H2 S), a gasotransmitter, has been revealed to get involved in hypertension, insulin secretion and regulation of vascular tone especially in erectile physiology. This study aimed to investigate the effect of H2 S on metS-induced ED. Animals were divided into two groups as control and metS, which were fed with standard diet or 60% high-fructose diet for 10 weeks respectively. The metS model was evaluated with biochemical analyses, waist circumference/tibia length ratio and HOMA index...
September 13, 2017: Andrologia
https://www.readbyqxmd.com/read/28880400/effects-of-ivermectin-and-its-combination-with-alpha-lipoic-acid-on-expression-of-igfbp-3-and-hspa1-genes-and-male-rat-fertility
#11
Z K El-Maddawy, W S H Abd El Naby
This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin-like growth factor binding protein-3 (IGFBP-3) and heat-shock protein A1 (HSPA1)) genes in the testes, as well as on male rat fertility parameters. Results revealed that expression levels of IGFBP-3 and HSPA1 were significantly increased in testis of the IVM-treated group relative to the control group...
September 7, 2017: Andrologia
https://www.readbyqxmd.com/read/28871600/effect-of-ghrelin-on-total-antioxidant-capacity-lipid-peroxidation-sperm-parameters-and-fertility-in-mice-against-oxidative-damage-caused-by-cyclophosphamide
#12
R Salimnejad, J Soleimani Rad, D Mohammad Nejad, L Roshangar
Cyclophosphamide is a drug used for chemotherapy and as an immune-suppressive in the organ transplantation. Despite its many clinical implications in the treatment of cancers, this drug has toxic effects on the reproductive system. This study aimed to evaluate the effect of ghrelin against the damages caused by cyclophosphamide. In this experimental study, 40 male mice were randomly divided into four groups: (i) control; (ii) cyclophosphamide; (iii) cyclophosphamide + ghrelin; and (iv) ghrelin. Cyclophosphamide (100 mg/kg body weight), once a week, and ghrelin (80 μg/kg body weight), daily, were administered intraperitoneally for 5 weeks...
September 4, 2017: Andrologia
https://www.readbyqxmd.com/read/28856704/health-related-quality-of-life-s-dependence-on-socio-economic-status-and-demographic-characteristics-among-men-with-benign-prostatic-hyperplasia
#13
K Kosilov, S Loparev, I Kuzina, L Kosilova, M Ivanovskaya, A Prokofyeva
This study investigated the effect of socio-economic status (SES) on health-related quality of life (HRQoL) among persons with benign prostatic hyperplasia (BPH). The data were collected by way of surveying persons with BPH aged from 35 to 85 (937) and selected via random sample. The diagnosis was confirmed with the use of I-PSS questionnaires (8-19 points), OABq-AT (≥8 points) and daily urinations. A study on HRQoL was conducted using the SF-36 questionnaire. SES was evaluated using the patients' ambulance cards (F112U) and tax inspection documents with their written permission...
August 30, 2017: Andrologia
https://www.readbyqxmd.com/read/28856695/association-between-body-mass-index-and-sperm-quality-and-sperm-dna-integrity-a-large-population-study
#14
J B A Oliveira, C G Petersen, A L Mauri, L D Vagnini, A Renzi, B Petersen, M Mattila, F Dieamant, R L R Baruffi, J G Franco
This study aimed to analyse whether the functional quality of spermatozoa is associated with body mass index (BMI). Semen samples were obtained from 1824 men undergoing fertility evaluation/treatment. Semen analysis was performed using World Health Organization (WHO) criteria, and morphology was evaluated with the motile sperm organelle morphology examination (MSOME). The percentages of sperm DNA fragmentation (using TdT (terminal deoxynucleotidyl transferase)-mediated dUTP nick-end labelling (TUNEL) assays), sperm chromatin packaging/underprotamination (using chromomycin A3/CMA3 ), mitochondrial damage (using MitoTracker Green) and apoptosis (using annexin V) were also assessed...
August 30, 2017: Andrologia
https://www.readbyqxmd.com/read/28853171/relationship-between-morphological-abnormalities-in-commercial-bull-frozen-semen-doses-and-conception-rate
#15
M S Ghirardosi, M L Fischman, A E Jorge, D Chan, H Cisale
Commercial doses of frozen bull semen for artificial insemination may have a certain percentage of morphological defects, despite being subject to prior selection. The aims of this study were to determine the prevalence of morphological abnormalities in commercial doses (n = 55, r = 2) of dairy and beef bulls, from AI Centers and to determine the possible existence of differences between them, regarding the percentage of abnormal spermatozoa. At least 200 spermatozoa per sample were evaluated using Bengal Rose stain (3% m/v) and light microscopy (×1000 magnification)...
August 29, 2017: Andrologia
https://www.readbyqxmd.com/read/28840607/andrology-on-the-internet-most-wanted-controversial-and-often-primary-source-of-information-for-patients
#16
M Baunacke, C Groeben, H Borgmann, J Salem, S Kliesch, J Huber
The Internet is an important source of health information with relevant impact on the physician-patient relationship. The German urological associations host one of the most comprehensive platforms for patient information on urological diseases. The aim of the study was to characterise its users and their specific needs. We invited users of the website www.urologenportal.de via pop-up to complete a 26-item online survey to evaluate health-related behaviour, distress and decision-making preferences. We received n = 551 complete responses...
August 25, 2017: Andrologia
https://www.readbyqxmd.com/read/28836280/molecular-characterisation-of-a-case-of-dicentric-y-presented-as-nonobstructive-azoospermia-with-testicular-early-maturation-arrest
#17
P Kumar, M Jain, A K Kalsi, A Halder
The dicentric Y chromosome is the most common cytogenetically visible structural abnormality of Y chromosome. The sites of break and fusion of dicentric Y are variable, but break and fusion at Yq12 (proximal to the pseudoautosomal region 2/PAR 2) is very rare. Dicentric Y chromosome is unstable during cell division and likely to generate chromosomal mosaicism. Here, we report a case of infertile male with nonmosaic 46,XY where chromosome Y was dicentric with break and fusion at Yq12 (proximal to PAR 2). Clinical presentation of the case was nonobstructive azoospermia due to early maturation arrest at the primary spermatocyte stage...
August 24, 2017: Andrologia
https://www.readbyqxmd.com/read/28786220/increased-risk-of-a-herpes-zoster-attack-in-patients-receiving-androgen-deprivation-therapy-for-prostate-cancer
#18
F J Wu, L T Kao, S Y Sheu, H C Lin, S D Chung
This study aimed to examine the association of herpes zoster (HZ) with androgen deprivation therapy (ADT) use among patients with prostate cancer (PC), using a population-based data set. The study sample for this study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We selected 877 patients with PC who had received ADT as the study group, while 849 patients with PC who had not received ADT served as the comparison group. Each study patient was individually tracked for a 3-year period to discriminate those who subsequently received a diagnosis of HZ...
August 8, 2017: Andrologia
https://www.readbyqxmd.com/read/28786134/expression-and-distribution-of-key-proteins-of-the-endocannabinoid-system-in-the-human-seminal-vesicles
#19
S Ückert, G la Croce, A Bettiga, K Albrecht, R Buono, F Benigni, M A Kuczyk, P Hedlund
The endocannabinoid system (ECS), comprising the cannabinoid receptors (CBR), their ligands, and enzymes controlling the turnover of endocannabinoids, has been suggested to be involved in male reproductive function. As information is scarce on the expression of the ECS in human male reproductive tissues, this study aimed to investigate by means of molecular biology (RT-PCR) and immunohistochemistry/immunofluorescence the expression and distribution of CB1 and CB2, GPR55 (an orphan G protein-coupled receptor that recognises cannabinoid ligands) and FAAH (isoforms 1 and 2) in the human seminal vesicles (SV)...
August 8, 2017: Andrologia
https://www.readbyqxmd.com/read/28786126/serum-relaxin-3-hormone-relationship-to-male-delayed-puberty
#20
S Hanafy, J H Sabry, E M Akl, R A Elethy, T Mostafa
Puberty is the transitional period between childhood and adulthood, a process encompassing morphological, physiological and behavioural development to attain full reproductive capability. This study aimed to assess serum relaxin-3 hormone relationship with male delayed puberty. Sixty males were investigated as two equal groups: males with delayed puberty and healthy matched males as controls. They were subjected to history taking, clinical examination and estimation of serum FSH, LH, testosterone, relaxin-3 hormonal levels...
August 8, 2017: Andrologia
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