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Acta Biotheoretica

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https://www.readbyqxmd.com/read/29761301/importance-of-initial-concentration-of-factor-viii-in-a-mechanistic-model-of-in-vitro-coagulation
#1
M Susree, M Anand
This computational study generates a hypothesis for the coagulation protein whose initial concentration greatly influences the course of coagulation. Many clinical malignancies of blood coagulation arise due to abnormal initial concentrations of coagulation factors. Sensitivity analysis of mechanistic models of blood coagulation is a convenient method to assess the effect of such abnormalities. Accordingly, the study presents sensitivity analysis, with respect to initial concentrations, of a recently developed mechanistic model of blood coagulation...
May 14, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29761300/natural-selection-and-drift-as-individual-level-causes-of-evolution
#2
Pierrick Bourrat
In this paper I critically evaluate Reisman and Forber's (Philos Sci 72(5):1113-1123, 2005) arguments that drift and natural selection are population-level causes of evolution based on what they call the manipulation condition. Although I agree that this condition is an important step for identifying causes for evolutionary change, it is insufficient. Following Woodward, I argue that the invariance of a relationship is another crucial parameter to take into consideration for causal explanations. Starting from Reisman and Forber's example on drift and after having briefly presented the criterion of invariance, I show that once both the manipulation condition and the criterion of invariance are taken into account, drift, in this example, should better be understood as an individual-level rather than a population-level cause...
May 14, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29744615/systems-biology-systems-medicine-systems-pharmacology-the-what-and-the-why
#3
Angélique Stéphanou, Eric Fanchon, Pasquale F Innominato, Annabelle Ballesta
Systems biology is today such a widespread discipline that it becomes difficult to propose a clear definition of what it really is. For some, it remains restricted to the genomic field. For many, it designates the integrated approach or the corpus of computational methods employed to handle the vast amount of biological or medical data and investigate the complexity of the living. Although defining systems biology might be difficult, on the other hand its purpose is clear: systems biology, with its emerging subfields systems medicine and systems pharmacology, clearly aims at making sense of complex observations/experimental and clinical datasets to improve our understanding of diseases and their treatments without putting aside the context in which they appear and develop...
May 9, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29728954/theoretical-assessment-of-the-impact-of-climatic-factors-in-a-vibrio-cholerae-model
#4
G Kolaye, I Damakoa, S Bowong, R Houe, D Békollè
A mathematical model for Vibrio Cholerae (V. Cholerae) in a closed environment is considered, with the aim of investigating the impact of climatic factors which exerts a direct influence on the bacterial metabolism and on the bacterial reservoir capacity. We first propose a V. Cholerae mathematical model in a closed environment. A sensitivity analysis using the eFast method was performed to show the most important parameters of the model. After, we extend this V. cholerae model by taking account climatic factors that influence the bacterial reservoir capacity...
May 4, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29713844/the-origin-of-species-by-means-of-mathematical-modelling
#5
Nikolai Bessonov, Natalia Reinberg, Malay Banerjee, Vitaly Volpert
Darwin described biological species as groups of morphologically similar individuals. These groups of individuals can split into several subgroups due to natural selection, resulting in the emergence of new species. Some species can stay stable without the appearance of a new species, some others can disappear or evolve. Some of these evolutionary patterns were described in our previous works independently of each other. In this work we have developed a single model which allows us to reproduce the principal patterns in Darwin's diagram...
April 30, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29700660/drug-repositioning-by-integrating-known-disease-gene-and-drug-target-associations-in-a-semi-supervised-learning-model
#6
Duc-Hau Le, Doanh Nguyen-Ngoc
Computational drug repositioning has been proven as a promising and efficient strategy for discovering new uses from existing drugs. To achieve this goal, a number of computational methods have been proposed, which are based on different data sources of drugs and diseases. These methods approach the problem using either machine learning- or network-based models with an assumption that similar drugs can be used for similar diseases to identify new indications of drugs. Therefore, similarities between drugs and between diseases are usually used as inputs...
April 26, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29700659/mathematical-basis-of-predicting-dominant-function-in-protein-sequences-by-a-generic-hmm-ann-algorithm
#7
Siddhartha Kundu
The accurate annotation of an unknown protein sequence depends on extant data of template sequences. This could be empirical or sets of reference sequences, and provides an exhaustive pool of probable functions. Individual methods of predicting dominant function possess shortcomings such as varying degrees of inter-sequence redundancy, arbitrary domain inclusion thresholds, heterogeneous parameterization protocols, and ill-conditioned input channels. Here, I present a rigorous theoretical derivation of various steps of a generic algorithm that integrates and utilizes several statistical methods to predict the dominant function in unknown protein sequences...
April 26, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29687203/adaptive-control-based-harvesting-strategy-for-a-predator-prey-dynamical-system
#8
Moitri Sen, Ashutosh Simha, Soumyendu Raha
This paper deals with designing a harvesting control strategy for a predator-prey dynamical system, with parametric uncertainties and exogenous disturbances. A feedback control law for the harvesting rate of the predator is formulated such that the population dynamics is asymptotically stabilized at a positive operating point, while maintaining a positive, steady state harvesting rate. The hierarchical block strict feedback structure of the dynamics is exploited in designing a backstepping control law, based on Lyapunov theory...
April 23, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29675730/graphical-representation-and-similarity-analysis-of-dna-sequences-based-on-trigonometric-functions
#9
Guo-Sen Xie, Xiao-Bo Jin, Chunlei Yang, Jiexin Pu, Zhongxi Mo
In this paper, we propose two four-base related 2D curves of DNA primary sequences (termed as F-B curves) and their corresponding single-base related 2D curves (termed as A-related, G-related, T-related and C-related curves). The constructions of these graphical curves are based on the assignments of individual base to four different sinusoidal (or tangent) functions; then by connecting all these points on these four sinusoidal (tangent) functions, we can get the F-B curves; similarly, by connecting the points on each of the four sinusoidal (tangent) functions, we get the single-base related 2D curves...
April 19, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29616380/culture-and-the-trajectories-of-developmental-pathology-insights-from-control-and-information-theories
#10
Rodrick Wallace
Cognition in living entities-and their social groupings or institutional artifacts-is necessarily as complicated as their embedding environments, which, for humans, includes a particularly rich cultural milieu. The asymptotic limit theorems of information and control theories permit construction of a new class of empirical 'regression-like' statistical models for cognitive developmental processes, their dynamics, and modes of dysfunction. Such models may, as have their simpler analogs, prove useful in the study and re-mediation of cognitive failure at and across the scales and levels of organization that constitute and drive the phenomena of life...
April 3, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29564667/quaternion-based-texture-analysis-of-multiband-satellite-images-application-to-the-estimation-of-aboveground-biomass-in-the-east-region-of-cameroon
#11
Cedrigue Boris Djiongo Kenfack, Olivier Monga, Serge Moto Mpong, René Ndoundam
Within the last decade, several approaches using quaternion numbers to handle and model multiband images in a holistic manner were introduced. The quaternion Fourier transform can be efficiently used to model texture in multidimensional data such as color images. For practical application, multispectral satellite data appear as a primary source for measuring past trends and monitoring changes in forest carbon stocks. In this work, we propose a texture-color descriptor based on the quaternion Fourier transform to extract relevant information from multiband satellite images...
March 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29546657/a-3d-individual-based-model-to-study-effects-of-chemotaxis-competition-and-diffusion-on-the-motile-phytoplankton-aggregation
#12
Ilhem Bouderbala, Nadjia El Saadi, Alassane Bah, Pierre Auger
In this paper, we develop a 3D-individual-based model (IBM) to understand effect of various small-scale mechanisms in phytoplankton cells, on the cellular aggregation process. These mechanisms are: spatial interactions between cells due to their chemosensory abilities (chemotaxis), a molecular diffusion and a demographical process. The latter is considered as a branching process with a density-dependent death rate to take into account the local competition on resources. We implement the IBM and simulate various scenarios under real parameter values for phytoplankton cells...
March 15, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29532347/prediction-of-apoptosis-protein-s-subcellular-localization-by-fusing-two-different-descriptors-based-on-evolutionary-information
#13
Yunyun Liang, Shengli Zhang
The apoptosis protein has a central role in the development and the homeostasis of an organism. Obtaining information about the subcellular localization of apoptosis protein is very helpful to understand the apoptosis mechanism and the function of this protein. Prediction of apoptosis protein's subcellular localization is a challenging task, and currently the existing feature extraction methods mainly rely on the protein's primary sequence. In this paper we develop a feature extraction model based on two different descriptors of evolutionary information, which contains the 192 frequencies of triplet codons (FTC) in the RNA sequence derived from the protein's primary sequence and the 190 features from a detrended forward moving-average cross-correlation analysis (DFMCA) based on a position-specific scoring matrix (PSSM) generated by the PSI-BLAST program...
March 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29460099/r-0-host-longevity-matters
#14
L M Viljoen, L Hemerik, J Molenaar
The basic reproduction ratio, R0 , is a fundamental concept in epidemiology. It is defined as the total number of secondary infections brought on by a single primary infection, in a totally susceptible population. The value of R0 indicates whether a starting epidemic reaches a considerable part of the population and causes a lot of damage, or whether it remains restricted to a relatively small number of individuals. To calculate R0 one has to evaluate an integral that ranges over the duration of the infection of the host...
March 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29177713/a-model-of-isotope-separation-in-plants
#15
A V Melkikh, A O Bokunyaeva
A model representing isotope separation during water evaporation in plants was constructed. The model accounts for substance diffusion, convective transfer and evaporation from the surface of the leaves. The dependence of the system's separation and enrichment coefficients on various parameters (liquid velocity, diffusion coefficient, and potential barriers for molecules and their thermal velocities) was determined. A comparison was made between the enrichment coefficients calculated from experimental data from different plants and those based on the model...
December 2017: Acta Biotheoretica
https://www.readbyqxmd.com/read/28791536/on-scott-phillips-general-account-of-communication
#16
Ronald J Planer
The purpose of this paper is to critically engage with a recent attempt by Thom Scott-Phillips to offer a general account of communication. As a general account, it is intended to apply equally well to both non-human and human interactions which are prima facie communicative in character. However, so far, Scott-Phillips has provided little detail regarding how his account is supposed to apply to the latter set of cases. After presenting what I take to be the most plausible way of filling in those details, I argue that his account would appear to be too narrow: it (minimally) fails to capture a range of human interactions which strike us as instances of communication...
December 2017: Acta Biotheoretica
https://www.readbyqxmd.com/read/28695410/microscale-gaseous-slip-flow-in-the-insect-trachea-and-tracheoles
#17
S M Simelane, S Abelman, F D Duncan
An analytical investigation into compressible gas flow with slight rarefactions through the insect trachea and tracheoles during the closed spiracle phase is undertaken, and a complete set of asymptotic analytical solutions is presented. We first obtain estimates of the Reynolds and Mach numbers at the channel terminal ends where the tracheoles directly deliver respiratory gases to the cells, by comparing the magnitude of the different forces in the compressible gas flow. The 2D Navier-Stokes equations with a slip boundary condition are used to investigate compressibility and rarefied effects in the trachea and tracheoles...
September 2017: Acta Biotheoretica
https://www.readbyqxmd.com/read/28501896/what-do-biologists-make-of-the-species-problem
#18
Bruno Pušić, Pavel Gregorić, Damjan Franjević
The concept of species is one of the core concepts in biology and one of the cornerstones of evolutionary biology, yet it is rife with conceptual problems. Philosophers of biology have been discussing the concept of species for decades, and in doing so they sometimes appeal to the views of biologists. However, their statements as to what biologists think are seldom supported by empirical data. In order to investigate what biologists actually think about the key issues related to the problem of species, we have conducted a survey on the sample of 193 biologists from the population of biologists from over 150 biology departments at universities in the US and the EU...
September 2017: Acta Biotheoretica
https://www.readbyqxmd.com/read/28493088/establishing-a-framework-for-a-natural-area-taxonomy
#19
Malte C Ebach, Bernard Michaux
The identification of areas of endemism is essential in building an area classification, but plays little role in how natural areas are discovered. Rather area monophyly, derived from cladistics, is essential in the discovery of natural area classifications or area taxonomy. We propose Area Taxonomy to be a new sub-discipline of historical biogeography, one that can be revised and debated, and which has its own area nomenclature. Separately to area taxonomy, we outline how natural areas may be discovered by transcribing the concepts of homology and monophyly from biological systematics to historical biogeography, in the form of area homologues, area homologies and area monophyly...
September 2017: Acta Biotheoretica
https://www.readbyqxmd.com/read/28474106/asymptotic-behavior-of-a-chemostat-model-with-constant-recycle-sludge-concentration
#20
Mohamed Amine Hamra, Karim Yadi
In this work, we study a several species aerobic chemostat model with constant recycle sludge concentration in continuous culture. We reduce the number of parameters by considering a dimensionless model. First, the existence of a global positive uniform attractor for the model with different removal rates is proved using the theory of dissipative dynamical systems. Hence, we investigate the asymptotic behavior of the model under small perturbations using methods of singular perturbation theory and we prove that, in the case of two species in competition, the unique equilibrium which is positive is globally asymptotically stable...
September 2017: Acta Biotheoretica
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