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Panminerva Medica

Dinesh K Chellapan, Wei Sheng Yap, Nurfatihah A Bt Ahmad Suhaimi, Gaurav Gupta, Kamal Dua
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing at an alarming rate. With an increased understanding of the pathophysiology and pathogenesis of T2DM, various new therapeutic options have been developed to target different key defects in T2DM. Incremental innovations of existing therapies either through unprecedented drug combinations, modified drug molecules, or improved delivery systems are capable to nullify some of the undesirable side effects of traditional therapies as well as to enhance effectiveness...
April 24, 2018: Panminerva Medica
Jiaxi Pan, Weiwei Wang, Xiaoxue Wu, Fanqi Kong, Jialin Pan, Jiafeng Lin, Minxue Zhang
BACKGROUND: To investigate the changes of inflammatory cytokines in cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation and the effects of metoprolol on them. METHODS: A total of 92 cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation in our hospital from April 2015 to March 2017 were selected and randomly divided into the control group and the observation group, with 46 cases in each group. Three months after pacemaker implantation, the control group was treated with aspirin, the observation group was treated with metoprolol on the basis of aspirin, and the curative effects were compared between the two groups...
April 24, 2018: Panminerva Medica
Filippo Patrucco, Ludovica Venezia, Francesco Gavelli, Rinaldo Pellicano, Paolo Solidoro
Alpha-1 antitrypsin deficiency (AATD) is a clinically under-recognized inherited disorder affecting the lungs and the liver. The most common manifestations are pulmonary emphysema, bronchiectasis and liver disease. The recent publication of the European Respiratory Society statement on diagnosis and treatment of pulmonary diseases has replaced the 2003 American Thoracic Society and European Respiratory Society one. New outcome parameters have been introduced and validated by observational and randomized clinical trials, and new information about efficacy and safety of augmentation therapy have been published...
April 24, 2018: Panminerva Medica
Richard Conway, Declan Byrne, Seán Cournane, Deirdre O'riordan, Bernard Silke
No abstract text is available yet for this article.
April 24, 2018: Panminerva Medica
Alessandra Gasparini, Nicola Poloni, Ivano Caselli, Marta Ielmini, Camilla Callegari
No abstract text is available yet for this article.
April 24, 2018: Panminerva Medica
Phillipe Romanet, Martine Guy, Francois-André Allaert
BACKGROUND: of the study: The primary objective of this trial was to demonstrate the effect of wearing a Hearing aid (HA) on improvement of hearing and comprehension in everyday life situations. METHODS: This mono-centre phase IV open-label clinical trial was carried out on men or women 40 years old or more, presenting mild or moderate first-degree presbyacusis. Presbyacusis was diagnosed by performance of pure-tone audiometry in silence. The main criterion was the comparison of the Glasgow Hearing Aid Benefit Profile (GHABP) before wearing HA and after a month of use and the secondary one was audiometric parameters...
April 17, 2018: Panminerva Medica
Andrea Marengo
No abstract text is available yet for this article.
March 15, 2018: Panminerva Medica
Alberto Pilotto, Simone Dini, Nicola Veronese, Julia Daragjati, Manuela Miolo, Monica M Mion, Andrea Fontana, Mario Lo Storto, Martina Zaninotto, Giada Bragato, Alberto Cella, Paolo Carraro, Filomena Addante, Massimiliano Copetti, Mario Plebani
BACKGROUND: To evaluate the prognostic accuracy of pro-ADM (adrenomedullin) in comparison with and in addition to the Multidimensional Prognostic Index (MPI), a validated predictive tool for mortality derived from a Comprehensive Geriatric Assessment (CGA), to predict one-month mortality risk in older patients hospitalized with community-acquired pneumonia (CAP). METHODS: All patients aged 65 years and older, consecutively admitted to an acute geriatric ward with a diagnosis of CAP from February to July 2012...
March 15, 2018: Panminerva Medica
Bartolomeo Lorenzati, Riccardo Cristofori, Andrea Landi, Enrico Ruffini, Domenico Novero, Giuseppe Lauria, Bruno M Tartaglino, Alberto Oliaro, Luca Scaglione, Elio Rolfo
No abstract text is available yet for this article.
March 15, 2018: Panminerva Medica
Kamal Dua, Rajendra Awasthi, Jyotsana R Madan, Dinesh K Chellappan, Buchi N Nalluri, Gaurav Gupta, Mary Bebawy, Philip M Hansbro
No abstract text is available yet for this article.
February 26, 2018: Panminerva Medica
Gianni Belcaro, Giuseppe Gizzi, Luciano Pellegrini, Beatrice Feragalli, Roberto Cotellese, Marisa Cacchio, Marcello Corsi
BACKGROUND: The aim of this registry was to evaluate the effects of Pycnogenol® on the main symptoms of irritable bowel syndrome (IBS) in otherwise healthy individuals. METHODS: This study included 77 healthy individuals with symptoms of IBS. The patients were divided into three groups: group 1 was treated with Buscopan (10 mg when needed), group 2 (Antispasmina col forte; 50 mg papaverine hydrochloride+10 mg belladonna extract when needed) and 3 (Pycnogenol® 150 mg/day) for 3 weeks...
June 2018: Panminerva Medica
Andrea Ledda, Gianni Belcaro, Beatrice Feragalli, Morio Hosoi, Marisa Cacchio, Roberta Luzzi, Mark Dugall, Roberto Cotellese, Maria R Cesarone
BACKGROUND: The aim of this study was to evaluate the efficacy of Robuvit® (French oak extract, Horphag Research) in improving kidney function in subjects with temporary kidney dysfunction (TKD) and increased oxidative stress levels. METHODS: Fifty-seven subjects with TKD were included in the registry. Subjects were divided into two goups according to albumin levels in the urine. Plasma free radicals were measured in order to evaluate a possible connection with alterations in kidney function...
June 2018: Panminerva Medica
François-André Allaert, Romain Schueller, Frederic Mabile, Laurette Vincent, Claudia Ferreira
BACKGROUND: ZENEO® (Crossject, Dijon France) is a novel prefilled, disposable needle-free auto-injector (AI) device under development for drug deliverer in a variety of routine-use or emergency situations. At present, reported user experience and patient preferences are limited. To determine what impact different forms of user instructions may have on successful use of the ZENEO® device. METHODS: We conducted a human factors study on 134 healthy volunteers. On enrolment, subjects were provided with different instructive training material; a device quick guide plus either use of a dummy training device, an illustrated leaflet, or a demonstration video...
June 2018: Panminerva Medica
Gian P Caviglia, Davide G Ribaldone, Chiara Rosso, Giorgio M Saracco, Marco Astegiano, Rinaldo Pellicano
Fecal calprotectin (FC) is a calcium-binding protein with antimicrobic, imunomodulatory and antiproliferative properties that is mainly found in the cytoplasm of neutrophil granulocytes. During the last decades, FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. FC correlates with clinical scoring systems and endoscopic lesions in IBD and is considered a reliable biomarker for the prediction of clinical relapse or remission...
March 2018: Panminerva Medica
Kamal Dua, Terezinha de Jesus Andreoli Pinto, Dinesh K Chellappan, Gaurav Gupta, Mary Bebawy, Philip M Hansbro
No abstract text is available yet for this article.
March 2018: Panminerva Medica
Bala Devi, Yogesh Kumar, Birendra Shrivastav, Ganesh N Sharma, Gaurav Gupta, Kamal Dua
No abstract text is available yet for this article.
March 2018: Panminerva Medica
Agustí Marfany, Cristina Sierra, Miguel Camafort, Mónica Doménech, Antonio Coca
Alzheimer's disease (AD), the most common form of dementia, is a complex disease, the mechanisms of which are poorly understood. AD represents 70% of all dementia cases, affecting up to 50% of elderly persons aged 85 or older, with functional dependence, poor quality of life, institutionalization and mortality. Advanced age is the main risk factor of AD, that is why population ageing, due to life expectancy improvements, increases AD incidence and prevalence, as well as the economic, social, and emotional costs associated with this illness...
March 2018: Panminerva Medica
Giovanni Cestaro, Gennaro Quarto, Marco DE Monti, Fabrizio Fasolini, Marco DE Fazio, Ermenegildo Furino, Maurizio Gentile
No abstract text is available yet for this article.
March 2018: Panminerva Medica
Gaurav Gupta, Dinesh K Chellappan, Terezinha de Jesus Andreoli Pinto, Philip M Hansbro, Mary Bebawy, Kamal Dua
MicroRNAs (miRNAs) are non-coding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate post-transcriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR‑503, an associate of the "canonical" miRNA-16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence to show that miR‑503 functions as a tumor suppressor gene through its effects on target genes that regulate cell proliferation, migration, and invasion in tumor cells...
March 2018: Panminerva Medica
Adamasco Cupisti, Lorenzo Ghiadoni, Claudia Zullo, Michele Marchini, Enrico Varricchio, Alessandro Puntoni, Elisabetta Giglio, Ophelia Meniconi, Maria R Bruno, Maria F Egidi
BACKGROUND: Arterial hypertension is very common in chronic kidney disease (CKD) patients and its prevalence increases with lowering estimated glomerular filtration rate (eGFR). Blood pressure (BP) control is a cornerstone in the treatment of CKD patients but still most treatment decisions are based on office BP measurement (OBPM). The aim of this cross-sectional, retrospective study is to investigate the prevalence of hypertension phenotypes in CKD patients and whether different home (HBPM) or OBPM are associated with a different CKD stage and cardiovascular comorbidities...
March 2018: Panminerva Medica
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