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Panminerva Medica

Andrea Marengo
No abstract text is available yet for this article.
March 15, 2018: Panminerva Medica
Alberto Pilotto, Simone Dini, Nicola Veronese, Julia Daragjati, Manuela Miolo, Monica M Mion, Andrea Fontana, Mario Lo Storto, Martina Zaninotto, Giada Bragato, Alberto Cella, Paolo Carraro, Filomena Addante, Massimiliano Copetti, Mario Plebani
BACKGROUND: To evaluate the prognostic accuracy of pro-ADM (adrenomedullin) in comparison with and in addition to the Multidimensional Prognostic Index (MPI), a validated predictive tool for mortality derived from a Comprehensive Geriatric Assessment (CGA), to predict one-month mortality risk in older patients hospitalized with community-acquired pneumonia (CAP). METHODS: All patients aged 65 years and older, consecutively admitted to an acute geriatric ward with a diagnosis of CAP from February to July 2012...
March 15, 2018: Panminerva Medica
Bartolomeo Lorenzati, Riccardo Cristofori, Andrea Landi, Enrico Ruffini, Domenico Novero, Giuseppe Lauria, Bruno M Tartaglino, Alberto Oliaro, Luca Scaglione, Elio Rolfo
No abstract text is available yet for this article.
March 15, 2018: Panminerva Medica
François-André Allaert, Romain Schueller, Frederic Mabile, Laurette Vincent, Claudia Ferreira
BACKGROUND: ZENEO® (Crossject, Dijon France) is a novel pre-filled, disposable needle-free auto- injector (AI) device under development for drug deliverer in a variety of routine-use or emergency situations. At present, reported user experience and patient preferences are limited. To determine what impact different forms of user instructions may have on successful use of the ZENEO® device. METHODS: We conducted a human factors study on 134 healthy volunteers. On enrolment, subjects were provided with different instructive training material; a device quick guide plus either use of a dummy training device, an illustrated leaflet, or a demonstration video...
March 6, 2018: Panminerva Medica
Kamal Dua, Rajendra Awasthi, Jyotsana R Madan, Dinesh K Chellappan, Buchi N Nalluri, Gaurav Gupta, Mary Bebawy, Philip M Hansbro
No abstract text is available yet for this article.
February 26, 2018: Panminerva Medica
Ludovico Abenavoli, Rinaldo Pellicano, Luigi Boccuto
No abstract text is available yet for this article.
February 13, 2018: Panminerva Medica
Paolo Borro, Silvana G Dellepiane, Rinaldo Pellicano, Laura Gemme, Sharmila Fagoonee, Gianni Testino
OBJECTIVE: The need for a staging of hepatic fibrosis has become particularly urgent in the last few years in order to start new therapeutic treatments. The objective of this study is to identify ultrasound descriptors and achieve a staging of hepatic fibrosis with non-invasive, rapid and inexpensive methods, both as an alternative and a support to the ultrasound elastography examination. MATERIALS AND METHODS: This study evaluated 196 patients under treatment at the Alcohological Regional Center...
February 13, 2018: Panminerva Medica
Kamal Dua, Terezinha de Jesus Andreoli Pinto, Dinesh K Chellappan, Gaurav Gupta, Mary Bebawy, Philip M Hansbro
No abstract text is available yet for this article.
January 25, 2018: Panminerva Medica
Bala Devi, Yogesh Kumar, Birendra Shrivastav, Ganesh N Sharma, Gaurav Gupta, Kamal Dua
No abstract text is available yet for this article.
January 25, 2018: Panminerva Medica
Gaurav Gupta, Terezinha de Jesus Andreoli Pinto, Dinesh K Chellappan, Anurag Mishra, Himaja Malipeddi, Kamal Dua
Diabetes mellitus (DM) is frequently increased in many countries and become a serious health problem worldwide. Diabetes is associated with dysfunction of different organs such as heart, eyes, blood vessels, nerves, and kidneys. There is a strong connection between diabetes and cancer. Metformin is one of the most commonly prescribed oral antidiabetic medicines and it is suggested as the firstline therapy due to its comparatively safe, inexpensive, effective and welltolerated. Some of the in vitro and in vivo investigations proved that metformin may have a direct anticancer action by preventing the proliferation of malignant cells and formations of the colony, inducing arrest of cell cycle and apoptosis and suppressing tumour growth...
January 25, 2018: Panminerva Medica
Agusti Marfany, Cristina Sierra, Miguel Camafort, Monica Domenech, Antonio Coca
Alzheimer's disease (AD), the most common form of dementia, is a complex disease, the mechanisms of which are poorly understood. AD represents 70% of all dementia cases, affecting up to 50% of elderly persons aged 85 or older, with functional dependence, poor quality of life, institutionalization and mortality. Advanced age is the main risk factor of AD, that's why population ageing, due to life expectancy improvements, increases AD incidence and prevalence, as well as the economic, social, and emotional costs associated with this illness...
January 25, 2018: Panminerva Medica
Giovanni Cestaro, Gennaro Quarto, Marco DE Monti, Fabrizio Fasolini, Marco DE Fazio, Ermenegildo Furino, Maurizio Gentile
No abstract text is available yet for this article.
January 11, 2018: Panminerva Medica
Gian P Caviglia, Davide G Ribaldone, Chiara Rosso, Giorgio M Saracco, Marco Astegiano, Rinaldo Pellicano
Fecal calprotectin (FC) is a calcium-binding protein with antimicrobic, imunomodulatory and antiproliferative properties that is mainly found in the cytoplasm of neutrophil granulocytes. During the last decades, FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. FC correlates with clinical scoring systems and endoscopic lesions in IBD and is considered a reliable biomarker for the prediction of clinical relapse or remission...
March 2018: Panminerva Medica
Natalie Ertz-Archambault, Katalin Kelemen
Based on the current WHO Classification of Myeloid Neoplasms, cytogenetic findings play a central role in the diagnostic classification of the myeloid malignancies. Cytogenetic abnormalities detected at primary diagnosis may change over time. Karyotype changes can be characterized as cytogenetic evolution, cytogenetic regression or a combination of both. While the exact mechanism of cytogenetic evolution is not completely understood, the process of cytogenetic evolution is not random, but follows different, and often disease-specific patterns during progression and relapse of myeloid neoplasms...
December 2017: Panminerva Medica
Christiana Schernthaner, Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Alexander Lauten, Paul C Schulze, Bjoern Kabisch, Kristina Braun, Johanna Muessig, Maryna Masyuk, Uta C Hoppe, Malte Kelm, Christian Jung
BACKGROUND: Noninvasive ventilation (NIV) has a sigificant impact on mortality in acute respiratory failure (ARF). Predictive parameters for mortality are of high interest. METHODS: We retrospectively analyzed 3759 blood gas analysis and clinical parameters of 475 patients presenting with ARF based on acute cardiogenic pulmonary edema and/or pneumonia. The influence of peak arterial oxygen partial pressure levels (PaO2) with respect to its predictive value for in-hopital and long-term mortality was investigated...
December 2017: Panminerva Medica
Gian P Caviglia, Maria L Abate, Silvia Gaia, Elisa Petrini, Caterina Bosco, Antonella Olivero, Chiara Rosso, Alessia Ciancio, Rinaldo Pellicano, Giorgio M Saracco, Mario Rizzetto, Antonina Smedile
BACKGROUND: Reliable biomarkers for early detection of hepatocellular carcinoma (HCC) in patients with cirrhosis are lacking. We evaluated the use of miR-122, alpha-fetoprotein (AFP) and protein induced by vitamin k absence/antagonist II (PIVKA-II) for HCC risk prediction in patients with HBV-related cirrhosis under surveillance. METHODS: We first analyzed a group of 63 patients with HBV-related liver cirrhosis of whom 33 had HCC. Then we performed a retrospective analysis on another group of 13 cirrhotic patients who developed HCC during surveillance, of whom serial serum samples were available (at time of HCC diagnosis [T0], 6-9 months [T-1] and 12-18 months [T-2] before HCC detection)...
December 2017: Panminerva Medica
Gaurav Gupta, Dinesh K Chellappan, Terezinha de Jesus Andreoli Pinto, Philip M Hansbro, Mary Bebawy, Kamal Dua
MicroRNAs (miRNAs) are noncoding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate posttranscriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR503, an associate of the "canonical" miRNA16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence to show that miR503 functions as a tumor suppressor gene through its effects on target genes that regulate cell proliferation, migration, and invasion in tumor cells...
November 22, 2017: Panminerva Medica
Adamasco Cupisti, Lorenzo Ghiadoni, Claudia Zullo, Michele Marchini, Enrico Varricchio, Alessandro Puntoni, Elisabetta Giglio, Ophelia Meniconi, Maria R Bruno, Maria F Egidi
BACKGROUND: Arterial hypertension is very common in chronic kidney disease (CKD) patients and its prevalence increases with lowering estimated glomerular filtration rate (eGFR). Blood pressure (BP) control is a cornerstone in the treatment of CKD patients but still most treatment decisions are based on office BP measurement (OBPM). The aim of this cross-sectional, retrospective study is to investigate the prevalence of hypertension phenotypes in CKD patients and whether different home (HBPM) or OBPM are associated with a different CKD stage and cardiovascular comorbidities...
November 22, 2017: Panminerva Medica
Juhi Tiwari, Gaurav Gupta, Terezinha de Jesus Andreoli Pinto, Rahul Sharma, Kavita Pabreja, Yogesh Matta, Neha Arora, Anurag Mishra, Rakesh Sharma, Kamal Dua
Diabetes Mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of ß cells within the pancreas. This disease becomes the leading cause of death so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters...
November 10, 2017: Panminerva Medica
Lijuan Chen, Ping Qiang, Yang Shao
No abstract text is available yet for this article.
October 9, 2017: Panminerva Medica
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