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Panminerva Medica

Mariana Bertoncelli Tanaka, Ashok Agarwal, Sandro C Esteves
In our society, the number of couples with advanced reproductive age seeking fertility treatment is increasing steadily. While the negative effect of female age on assisted reproductive technology (ART) outcomes is well established, the impact of paternal age needs to be clarified. We reviewed the current literature to determine whether advanced paternal age affects the results of ART and the health of resulting offspring. We found that the published literature is overall supportive of a positive association between advanced paternal age (>40 years) and semen quality deterioration...
July 18, 2018: Panminerva Medica
Alessandro Conforti, Sandro C Esteves, Ida Strina, Silvia Picarelli, Giuseppe Iorio, Erika Rania, Fulvio Zullo, Giuseppe De Placido, Carlo Alviggi
The management of patients with a poor ovarian response (POR) to ovarian stimulation represents a challenging issue in reproductive medicine. Apart from economic burdens, the patient with POR has poor prognosis in assisted reproductive technology (ART), which represents a common cause of drop-out from treatment. To introduce a more nuanced picture of POR, the POSEIDON group developed novel criteria to identify and classify patients with low prognosis who undergo ART. The primary goal of POSEIDON criteria is to offer clinicians a pragmatic system to guide therapeutic management with the mindset to obtain the number of oocytes needed for improving ART success...
July 18, 2018: Panminerva Medica
Lixia Zhang, Qi Wu, Qian Zhang, Gan Lu, Yong Yuan, Tong Wang
No abstract text is available yet for this article.
July 18, 2018: Panminerva Medica
Francesco Di Pierro, Paolo Risso, Roberto Settembre
BACKGROUND: Hypericum perforatum is used as medicinal plant for mild to moderately severe depression. Several trials have found hypericum to be more effective than placebo or some antidepressant drugs, but the exact mechanism and most relevant compounds are still unclear. A possible hypothesis is that the antidepressant activity might be due to its multiplicity of bioactive compounds. Aim is to test if greater chemical complexity could result in a greater hypericum antidepressant action...
July 10, 2018: Panminerva Medica
Gianni Testino, Silvia Leone, Sharmila Fagoonee
No abstract text is available yet for this article.
July 10, 2018: Panminerva Medica
Sevann Helo, Peyton Thomas, Nicholas N Tadros
Testosterone has long been touted as the panacea for men wishing to restore their vitality, sexuality, and masculinity to that of their youth. While the benefits of testosterone are not mythical, they are definite. In this article we will review the various benefits of testosterone as it pertains to men's health and male infertility.
July 10, 2018: Panminerva Medica
Stine G Kristensen, Peter Humaidan, Kevin Coetzee
Mitochondria, known as the energy factories in all cells, are key regulators of multiple vital cellular processes and affect all aspects of mammalian reproduction, being essential for oocyte maturation, fertilization and embryonic development. Mitochondrial dysfunction is consequently implicated in disease as well as age-related infertility. Since mitochondria are inherited exclusively from the mother, the female gamete is central to reproductive outcome and therapeutic interventions, such as mitochondrial replacement therapies (MRT), and development of new diagnostic tools...
June 28, 2018: Panminerva Medica
Ricardo Miyaoka, José E Orosz, Arnold P Achermann, Sandro C Esteves
Intracytoplasmic sperm injection (ICSI) was developed to overcome the most severe forms of male factor infertility, including azoospermia. Retrieval of the male gamete from the epididymis or testis offers the possibility to perform ICSI and to provide biological parenthood for the affected men. Although reconstruction of the seminal tract is possible in many men with obstructive azoospermia (OA), this approach may not be feasible or desired by the couple 1. Unlike OA, non-obstructive azoospermia (NOA) is usually an untreatable condition associated with spermatogenic failure...
June 28, 2018: Panminerva Medica
Sandro C Esteves, José F Carvalho, Ciro D Martinhago, Augusto A Melo, Fabiola C Bento, Peter Humaidan, Carlo Alviggi
BACKGROUND: We developed a model to estimate the female age-dependent decrease in blastocyst euploidy and the impact of blastocyst cohort size on the likelihood of having at least one euploid blastocyst for transfer. METHODS: Retrospective analysis of 1,296 trophectoderm biopsies by next-generation sequencing analysis from 436 infertile couples undergoing intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy. A logistic regression model was fit to the data...
June 28, 2018: Panminerva Medica
Valeria Romanelli, Maurizio Poli, Antonio Capalbo
Preimplantation genetic testing is a methodology aimed at the assessment of the genetic composition of an embryo. This diagnostic approach has been used in assisted reproduction for almost thirty years. During these years, the technologies used for embryo's genetic analysis have been continuously improved allowing the development of more precise, comprehensive and robust strategies that are clinically employed nowadays. In this review, the main diagnostic approaches used for embryo genetic and chromosomal assessment are described and discussed both from an embryological and genetic standpoint...
June 28, 2018: Panminerva Medica
Giuliano M Bedoschi, Paula A Navarro, Kutluk H Oktay
Cancer is a worldwide public health problem and is the second leading cause of death in the United States. Early detection of cancer and advancement of treatment modalities contributed to declining mortality rates. Consequently, survival rates increased, leading to a greater interest in maintaining the quality of life after cancer treatment. Adjuvant chemotherapy results in an improvement in both disease-free and overall survival. However, chemotherapy treatment is associated with acute and long- term complications for cancer survivors...
June 28, 2018: Panminerva Medica
Matheus Roque, Beatrice Nuto Nóbrega, Marcello Valle, Marcos Sampaio, Selmo Geber, Thor Haahr, Peter Humaidan, Sandro C Esteves
Over the years concerns have arisen about possible adverse effects associated with controlled ovarian stimulation (COS) as regards not only the endometrium, but also on obstetrical and perinatal outcomes in pregnancies after fresh embryo transfer (ET) during in vitro fertilization (IVF) treatment. The improvements in cryopreservation techniques associated with the possible impairment in endometrial receptivity due to the supra-physiologic hormonal levels observed during conventional COS have increased the implementation of the so-called 'freeze-all' policy...
June 28, 2018: Panminerva Medica
Brigitte Barrois, Marie-Line Gaubert-Dahan, François-André Allaert, Ilinca Urzica, Bernard Bordet, Jean-Marc Michel, Marie-Ange Blanchon, Cédric Chol
BACKGROUND: The main study was a cross-sectional multicenter study of the prevalence of pressure ulcers in rehabilitation services (RS) where Axtair Automorpho® Plus mattresses were made available ad libitum. The primary objective was to enable comparison with prevalence as observed in the national PER SE study (historical control) in similar departments using a variety of prevention aids. METHODS: This cross-sectional prevalence study was combined with a prospective study of the incidence of pressure ulcer occurrence in the high-risk target population whose beds were systematically equipped with the studied support...
June 28, 2018: Panminerva Medica
Majdi Imterat, Ashok Agarwal, Sandro C Esteves, Jenna Meyer, Avi Harlev
As the global mean body mass index (BMI) is on the rise, the importance of understanding exactly how female fertility is impacted by once outlier BMI values, becomes ever more important. Studies have implicated abnormal BMI impacts the female reproductive system by contributing to anovulation, irregular menses, adverse oocyte quality, endometrial alterations, and hormonal imbalances that ultimately result in female infertility, which could complicate natural conception efforts and request considering assisted reproductive technology (ART) in such couples...
June 28, 2018: Panminerva Medica
Junling Zhang, Nannuan Liu, Chaoqun Yang
BACKGROUND: To investigate the clinical efficiency and safeness of the combination of rosuvastatin and nimodipine in treating mild cognitive impairment of CSVD patients. METHODS: A total of 120 patients with mild cognitive impairment caused by CSVD were divided randomly into two groups: an observation group and a control group, each of which had 60 patients. In the observation group, patients were given rosuvastatin in combination with nimodipine, and other patients were given nimodipine in the control group...
June 28, 2018: Panminerva Medica
Kamal Dua, Gaurav Gupta, Rajendra Awasthi, Dinesh K Chellappan
No abstract text is available yet for this article.
September 2018: Panminerva Medica
Kamal Dua, Jyotsana R Madan, Dinesh K Chellappan, Gaurav Gupta
No abstract text is available yet for this article.
September 2018: Panminerva Medica
Gaurav Gupta, Gautam Singhvi, Dinesh K Chellappan, Sanjay Sharma, Anurag Mishra, Rajiv Dahiya, Terezinha de Jesus Andreoli Pinto, Kamal Dua
Glioblastoma, also known as glioblastoma multiforme, is the most common and worldwide-spread cancer that begins within the brain. Glioblastomas represent 15% of brain tumors. The most common length of survival following diagnosis is 12 to 14 months with less than 3% to 5% of people surviving longer than five years. Without treatment, survival is typically 3 months. Among all receptors, special attention has been focused on the role of peroxisome proliferator-activated receptors (PPARs) in glioblastoma. PPARs are ligand-activated intracellular transcription factors...
September 2018: Panminerva Medica
Dinesh K Chellappan, Wei S Yap, Nurfatihah A Bt Ahmad Suhaimi, Gaurav Gupta, Kamal Dua
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing at an alarming rate. With an increased understanding of the pathophysiology and pathogenesis of T2DM, various new therapeutic options have been developed to target different key defects in T2DM. Incremental innovations of existing therapies either through unprecedented drug combinations, modified drug molecules, or improved delivery systems are capable to nullify some of the undesirable side effects of traditional therapies as well as to enhance effectiveness...
September 2018: Panminerva Medica
Jiaxi Pan, Weiwei Wang, Xiaoxue Wu, Fanqi Kong, Jialin Pan, Jiafeng Lin, Minxue Zhang
BACKGROUND: To investigate the changes of inflammatory cytokines in cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation and the effects of metoprolol on them. METHODS: A total of 92 cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation in our hospital from April 2015 to March 2017 were selected and randomly divided into the control group and the observation group, with 46 cases in each group. Three months after pacemaker implantation, the control group was treated with aspirin, the observation group was treated with metoprolol on the basis of aspirin, and the curative effects were compared between the two groups...
September 2018: Panminerva Medica
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