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Panminerva Medica

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https://www.readbyqxmd.com/read/28094491/the-first-line-treatment-of-helicobacter-pylori-infection-in-piedmont-in-the-year-2017
#1
Rinaldo Pellicano, Davide G Ribaldone, Sharmila Fagoonee, Marco Astegiano, Giorgio M Saracco
No abstract text is available yet for this article.
January 17, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28090764/incremental-and-infrequent-hemodialysis-a-new-paradigm-for-both-dialysis-initiation-and-conservative-management
#2
Connie M Rhee, Mehrdad Ghahremani-Ghajar, Yoshitsugu Obi, Kamyar Kalantar-Zadeh
Registry or national dialysis data show that a sizeable proportion of contemporary dialysis patients have substantial levels of residual kidney function especially upon transitioning to dialysis therapy. However, among incident hemodialysis patients, the prevailing paradigm has been to initiate "full-dose" thrice-weekly treatment schedules irrespective of native kidney function in most developed countries. Recognizing the benefits of residual kidney function upon the health and survival of dialysis patients, there has been growing interest in incremental hemodialysis, in which dialysis frequency and dose are tailored according to the degree of patients' residual kidney function...
January 13, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28090763/sodium-and-fluid-management-in-the-conservative-management-of-chronic-kidney-disease
#3
Morgan Marcuccilli, Jessica Kendrick, Michel Chonchol
Chronic kidney disease (CKD) imposes a significant global health burden. In the United States, one in three adults are at risk for CKD currently affecting over 28 million Americans. While several studies have demonstrated the benefit of treating traditional risk factors in CKD, including hypertension with pharmacologic agents such as blockade of the renin-angiotensin system (RAAS), there is scarce data on the advantages of sodium and fluid management in this population. Both experimental and observational studies have shown improvement in hypertension and cardiovascular outcomes with sodium restriction to < 2...
January 13, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28090762/use-of-ace-inhibition-and-blood-pressure-management-in-deferring-dialysis-initiation
#4
Lucia Del Vecchio, Ugo Teatini, Francesco Locatelli
Elevated blood pressure is one of the most significant risk factor for the development of chronic kidney disease (CKD); its treatment is a milestone in CKD management. While it is accepted that a stricter blood pressure control is indicated in patients with proteinuria or microalbuminuria, the exact degree of blood pressure reduction to be obtained in CKD patients is still under debate. Following more recent interpretation of old trials, a BP target for < 140/90 mmHg is suggested for non-proteinuric CKD patients...
January 13, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28001026/keto-analogues-and-essential-amino-acids-and-other-supplements-in-the-conservative-management-of-chronic-kidney-disease
#5
Adamasco Cupisti, Piergiorgio Bolasco
The manipulation of dietary protein intake is the mainstay of nutritional treatment of patients affected by chronic renal insufficiency, with an aim to reduce the burden of uremic toxins in order to decrease uremic toxicity and delay the need for dialysis. Consensus exists regarding the benefit of progressive protein restriction towards delaying the progression of renal failure and the need for dialysis, provided adequate energy supply. Although pivotal, protein restriction is only one aspect of the dietary management of CKD patients...
December 21, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/28001025/clinical-benefits-of-phosphate-control-in-progression-of-end-stage-renal-disease
#6
Piergiorgio Bolasco, Stefano Murtas
It is largely agreed that preservation of RKF has a directly proportional affect on general, and in particular cardiovascular, mortality. During evaluation of patients on infrequent hemodialysis (ID) as both as once-weekly or twice-weekly hemodialysis it has been frequently underestimated the importance of phosphaturia, Indeed, the native kidney preserves the ability to eliminate not only toxic molecules but also a significative output of phosphate despite of a severe decrease of residual kidney function (RKF)...
December 21, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/28001024/microbiota-and-prebiotics-modulate-uremic-toxins-generation
#7
Laetitia Koppe, Denis Fouque
Recent data have shown that the host-intestinal microbiota interaction is intrinsically linked with overall health. Chronic kidney disease (CKD) could influence intestinal microbiota and gut dysbiosis is also considered as a cause of progression of kidney disease. An increasing body of evidence indicates that dysbiosis is a key contributor of uremic retention solutes (URS) accumulating in patients with CKD. The discovery of the kidney- gut axis has created new therapeutic opportunities for nutritional intervention in order to prevent adverse outcomes...
December 21, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/28001023/modified-glasgow-prognostic-score-might-be-a-prognostic-factor-for-hepatocellular-carcinoma-a-meta-analysis
#8
Hong Chen, Nan Hu, Peng Chang, Tao Kang, Song Han, Yaoliang Lu, Maoquan Li
INTRODUCTION: Hepatocellular carcinoma (HCC) is the fifth-most common cancer. Recent studies have demonstrated that there was a relationship between modified Glasgow prognostic score (mGPS) and survival of HCC. However, the results were inconsistent. EVIDENCE ACQUISITION: The following databases were searched for relevant articles published up until June 2016: PubMed; EMBASE; Web of Science and the China National Knowledge Infrastructure. The strength of association between mGPS and OS of HCC was estimated by pooled HRs with corresponding 95% CIs...
December 21, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/27990791/the-role-of-carbon-adsorbent-in-the-conservative-management-of-chronic-kidney-disease
#9
Toshimitsu Niwa
Indoxyl sulfate is a uremic toxin, and cannot be removed efficiently by hemodialysis due to its protein-binding. Indoxyl sulfate induces cellular dysfunction by producing reactive oxygen species (ROS) such as superoxide by activating nicotinamide adenine dinucleotide phosphate oxidase, and by activating aryl hydrocarbon receptor through its uptake via organic anion transporters (OAT1 and OAT3). Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular cells, glomerular mesangial cells, vascular smooth muscle cells, vascular endothelial cells, cardiomyocytes, cardiac fibroblasts, monocytes, osteoblasts, osteoclasts, and myocytes...
December 16, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/27827529/a-design-thinking-approach-to-primary-ovarian-insufficiency
#10
Lisa A Martin, Alison G Porter, Vincent A Pelligrini, Peter F Schnatz, Xuezhi Jiang, Nicole Kleinstreuer, Janet E Hall, Sarah Verbiest, Jill Olmstead, Ryan Fair, Alberto Falorni, Luca Persani, Aleksandar Rajkovic, Khanjan Mehta, Lawrence M Nelson
Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. We also review the pathophysiology and management of primary ovarian insufficiency. Molecular understanding regarding the pathogenesis is essential to developing strategies for prevention, earlier diagnosis, and appropriate management of the disorder...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27759734/contemporary-techniques-for-coronary-cto-revascularization
#11
Vladimir Dedovic, Goran Stankovic
Despite permanent improvement in success rate and technical developments, chronic total occlusion (CTO) remains undertreated by percutaneous coronary intervention (PCI). Dedicated CTO operators from Japan, Europe and USA perform these procedures with success rate beyond 90%, but there is still huge gap between this group of specialists and broader population of PCI operators. Recently proposed CTO scores can be used for patients' selection according to the CTO operators' experience. Patients with low CTO Score values may be suitable for less experienced operators at the beginning of the CTO PCI learning curve, while more complex CTOs (higher CTO Score values) should be differed to CTO experts...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27711025/methotrexate-and-lung-disease-in-rheumatoid-arthritis
#12
Richard Conway, John J Carey
Rheumatoid arthritis (RA) is a common chronic inflammatory disease affecting many tissues and resulting in substantial morbidity and increased mortality. Arthritis is the most notable clinical feature, but extra-articular features can have devastating consequences. Pulmonary manifestations are common in RA, with high rates of disease related lung disease and a propensity to pulmonary infections. Respiratory illness remains a leading cause of death among RA populations. Modern medicine greatly reduces the illness burden among patients with RA, particularly through the use of disease-modifying medications...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27701367/current-management-of-diabetic-patients-with-kidney-disease-a-renal%C3%A2-cardio%C3%A2-endocrine-perspective
#13
Roberto Pecoits-Filho, José Fortes, Aléxei Volaco, Sergio Vencio, Andrei C Sposito
Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of diabetes mellitus type 2, affecting about one‑third of the patients. DKD results in increased hospitalizations and mortality rates, especially due to cardiovascular complications. This high burden of kidney disease is mainly due to the increasing complexity of in- outpatient care for patients with DM. There is a strikingly complex interaction of kidney dysfunction with many aspects of diabetes care, such as redefinition of targets of treatment, interactions of traditional and non‑traditional risk factors, and pharmacological issues related to pharmacokinetic and side effects of drugs...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27644257/downregulation-of-pigment-epithelium-derived-factor-is-associated-with-increased-epithelial-mesenchymal-transition-in-bladder-cancer
#14
Bin B Dong, Jia S Yan, Yang Y Yan, Tian C Xie, Liang Xu, Guang H Hu, Yun F Xu, Min Liu
BACKGROUND: Pigment epithelium-derived factor (PEDF) has been reported to inhibit angiogenesis in bladder cancer, but whether it modulates epithelial-mesenchymal transition (EMT) remains unknown. METHODS: We have included 68 samples of non-muscle invasive bladder cancer in this study. Immunohistochemistry was performed in all sample sections for expressions of PEDF, SNAI2, Vimentin and E-cadherin, which were quantified and The EMT Index (EMTi) was calculated by Vimentin/E-cadherin...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27636117/c-met-as-a-potential-novel-prognostic-marker-in-squamous-cell-carcinoma-and-adenocarcinoma-of-esophagus-evidence-from-a-meta-analysis
#15
Jing L Ren, Hui F Wu, Wen J Wang, Gui M Hu, Bin Gu, Min Zhang, Yu X Wang
INTRODUCTIONː The prognostic value of c-Met in patients with esophageal cancer (EC) remains inconsistent and controversial. Our study aims to clarify the correlation between c-Met overexpression and clinical outcome in EC patients. EVIDENCE ACQUISITIONː We performed a comprehensive search of EMBASE, PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biomedical Database (CBM) (from inception to May 1, 2016) for published literature regarding the potential association between c-Met overexpression and clinical outcome in EC patients...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27598891/starling-resistors-autoregulation-of-cerebral-perfusion-and-the-pathogenesis-of-idiopathic-intracranial-hypertension
#16
Roberto DE Simone, Angelo Ranieri, Vincenzo Bonavita
Two critical functions for the control of intracranial fluids dynamics are carried on the venous side of the perfusion circuit: the first is the avoidance of cortical veins collapse during the physiological increases of cerebrospinal fluid (CSF) pressure in which they are immersed. The second, is the generation of an abrupt venous pressure drop at the confluence of the cortical veins with the dural sinuses that is required to allow a CSF outflow rate balanced with its production. There is evidence that both of these effects are ensured by a Starling resistor mechanism (a fluid dynamic construct that governs the flow in collapsible tubes exposed to variable external pressure) acting at the confluence of cortical veins in the dural sinus...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27433879/effect-of-autophagy-on-cisplatin-induced-bladder-cancer-cell-apoptosis
#17
Zhiqiang Fan, Xuejun Huangfu, Zhonghua Liu
BACKGROUND: To investigate the effects of autophagy in cisplatin-induced apoptosis of bladder cancer cells. METHODS: Bladder cancer cell T24 was regarded as cell model. The transmission electron microscope was employed to detect autophagic vacuoles and the fluorescence microscope to detect the fluorescence accumulation profile of vectors for green fluorescent protein and microtubule associated protein 1 light chain 3 fusion protein (GFP-LC3). Protein immunoblotting was applied to detect the accumulation of LC3-II, thus detecting whether cisplatin could induce the bladder cancer T24 cell autophagy...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27314979/applications-of-cardiotoxicity-in-breast-cancer-a-meta-analysis
#18
Hossein Rahmani, Alireza Shahriary, Mohammad A Sheikhi, Ahmad Ebadi, Hannaneh Davoodzadeh
INTRODUCTION: Breast cancer is the most common type of cancer in women. Many antineoplastic agents used to treat breast cancer have potentially cardiotoxic effects and may lead to chemotherapy induced cardiomyopathy and heart failure. We conducted a meta-analysis to clarify the applications of cardiotoxicity in breast cancer. EVIDENCE ACQUISITION: A published literature search was performed through PubMed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27309259/pon1-l55m-polymorphism-might-contribute-to-the-risk-of-cancer
#19
Peizeng Hu, Yongchen Ma, Lingling Zhang, Sheng Ma
INTRODUCTION: The results involved in correlation of PON1 L55M polymorphism and cancer risk are still inconsistent and controversial. Therefore, we performed this comprehensive meta-analysis for the effects of PON1 L55M polymorphism and cancer risk. EVIDENCE ACQUISITION: We carried out a database search in PubMed (Medline) and EMBASE covering all published articles. The strength of association between PON1 L55M polymorphism and cancer risk was estimated by pooled ORs with corresponding 95% confidence intervals (CI)...
March 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27716738/a-2016-panorama-of-helicobacter-pylori-infection-key-messages-for-clinicians
#20
Rinaldo Pellicano, Davide G Ribaldone, Sharmila Fagoonee, Marco Astegiano, Giorgio M Saracco, Francis Mégraud
The discovery that the bacterium Helicobacter pylori (H. pylori) lives in the stomach has rendered out-of-date the concept of inhospitality of the gastric environment. H. pylori is able to survive in this organ through mechanisms of acid resistance and colonization factors. The prevalence of H. pylori infection varies depending on age, socioeconomic class, and country. Currently, in the context of a decreased trend in H. pylori prevalence, it is estimated that about 50% of the world's human population are carriers of the microorganism, with a higher rate in developing countries than in developed countries...
December 2016: Panminerva Medica
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