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Panminerva Medica

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https://www.readbyqxmd.com/read/28497938/cardiovascular-consequences-of-hypophosphatemia
#1
Nobuhiro Ariyoshi, Masayuki Nogi, Akika Ando, Hideaki Watanabe, Sari Umekawa
INTRODUCTION: Few studies have been conducted to evaluate the effect of hypophosphatemia on cardiovascular consequences. The goal of this review was to determine whether hypophosphatemia is associated with cardiovascular consequences and to increase its awareness as a new clinical entity and a reversible cause of cardiovascular consequences. EVIDENCE ACQUISITION: We searched MEDLINE and PubMed through September 2016 for primary studies that reported the relationship between hypophosphatemia and cardiovascular consequences including cardiomyopathy and arrhythmia...
May 12, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28488843/hotair-and-gastric-cancer-a-lesson-from-two-meta-analyses
#2
Sharmila Fagoonee, Marilena Durazzo
No abstract text is available yet for this article.
May 8, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28488842/sleep-disordered-breathing-in-heart-failure-patients-after-ventricular-assist-device-implantation-and-heart-transplantation
#3
Anindita Chowdhury, Reeba Mathew, Richard J Castriotta
Chronic heart failure (CHF) represents a major health and economic burden and is associated with high rates of hospital admission, morbidity, mortality and decreased quality-adjusted life years. New advances in the treatment of CHF such as ventricular assist devices (VADs) and heart transplantation have helped improve outcomes. Sleep-disordered breathing (SDB) is highly prevalent in CHF patients and the associated morbidity makes it essential for physicians to be more cognizant about its existence, interaction and need for treatment...
May 8, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28488841/catastrophic-antiphospholipid-syndrome-an-update
#4
Gerard Espinosa, Ignasi Rodriguez-Pinto, Ricard Cervera
Catastrophic antiphospholipid syndrome (CAPS) is a rare variant that accounts for 1% of patients with APS. Despite its low frequency, the mortality-related is very high ranging from 50% of patients in the first series to 37% in the most recent data. The current knowledge of this potential devastating entity comes from the International Registry of patients with CAPS, named CAPS Registry. Small vessel thrombosis, laboratory features of microangiopathic haemolytic anemia, and development of multisystem involvement in a very short period of time are the main characteristics of this syndrome...
May 8, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28399617/heart-failure-and-role-of-circulating-mmp-2-and-mmp-9
#5
Jana Radosinska, Miroslav Barancik, Norbert Vrbjar
The myocardial extracellular matrix (ECM) is the dynamic environment that is fundamental for the structural and physiological homeostasis of the heart. Alterations in ECM homeostasis may lead to diastolic or systolic dysfunction and consequent development of heart failure (HF). For degradation of ECM, matrix metalloproteinases (MMPs) are responsible. To the most frequently analyzed MMPs in relation to HF syndrome belong MMP-2 and MMP-9. This review summarizes the recent knowledge concerning the role of circulating MMP-2 and MMP-9 (i...
April 11, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28290189/helicobacter-pylori-2017-revitalized-therapies-for-an-ever-challenging-bug
#6
Giovanni C Actis
No abstract text is available yet for this article.
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28290188/vaccine-as-absolute-solution-of-helicobacter-pylori-infection
#7
Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28290187/which-first-line-treatment-in-piedmont-in-the-year-2017
#8
Mara Berrutti, Nicola Leone
No abstract text is available yet for this article.
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28290186/phosphorus-and-other-aspects-of-ckd-mbd-in-the-conservative-management-of-chronic-kidney-disease
#9
Anuja Shah
As the prevalence of chronic kidney disease (CKD) increases and the population ages, there is an imperative to offer cost effective and patient specific therapeutic options for the management of advanced CKD. In cases where there is a desire to avoid or delay renal replacement therapy, conservative options need to be defined and strategies for delaying the need for renal replacement therapy should be offered. CKD-mineral bone disorders (MBD) refers to the constellation of disturbances in abnormal bone and soft tissue calcification along with abnormalities, in phosphorus, calcium, parathyroid hormone, vitamin D, and FGF-23...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28290185/conservative-management-of-chronic-kidney-disease-how-to-avoid-or-defer-dialysis
#10
Piergiorgio Bolasco, Kamyar Kalantar-Zadeh, Connie Rhee
No abstract text is available yet for this article.
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28094491/the-first-line-treatment-of-helicobacter-pylori-infection-in-piedmont-in-the-year-2017
#11
Rinaldo Pellicano, Davide G Ribaldone, Sharmila Fagoonee, Marco Astegiano, Giorgio M Saracco
No abstract text is available yet for this article.
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28090764/incremental-and-infrequent-hemodialysis-a-new-paradigm-for-both-dialysis-initiation-and-conservative-management
#12
Connie M Rhee, Mehrdad Ghahremani-Ghajar, Yoshitsugu Obi, Kamyar Kalantar-Zadeh
Registry or national dialysis data show that a sizeable proportion of contemporary dialysis patients have substantial levels of residual kidney function especially upon transitioning to dialysis therapy. However, among incident hemodialysis patients, the prevailing paradigm has been to initiate "full-dose" triweekly treatment schedules irrespective of native kidney function in most developed countries. Recognizing the benefits of residual kidney function upon the health and survival of dialysis patients, there has been growing interest in incremental hemodialysis, in which dialysis frequency and dose are tailored according to the degree of patients' residual kidney function...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28090763/sodium-and-fluid-management-in-the-conservative-management-of-chronic-kidney-disease
#13
Morgan Marcuccilli, Jessica Kendrick, Michel Chonchol
Chronic kidney disease (CKD) imposes a significant global health burden. In the United States, one in three adults are at risk for CKD currently affecting over 28 million Americans. While several studies have demonstrated the benefit of treating traditional risk factors in CKD, including hypertension with pharmacologic agents such as blockade of the renin-angiotensin system (RAAS), there is scarce data on the advantages of sodium and fluid management in this population. Both experimental and observational studies have shown improvement in hypertension and cardiovascular outcomes with sodium restriction to ≤2...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28090762/use-of-ace-inhibition-and-blood-pressure-management-in-deferring-dialysis-initiation
#14
Lucia Del Vecchio, Ugo Teatini, Francesco Locatelli
Elevated blood pressure is one of the most significant risk factor for the development of chronic kidney disease (CKD); its treatment is a milestone in CKD management. While it is accepted that a stricter blood pressure control is indicated in patients with proteinuria or microalbuminuria, the exact degree of blood pressure reduction to be obtained in CKD patients is still under debate. Following more recent interpretation of old trials, a BP target for <140/90 mmHg is suggested for non-proteinuric CKD patients...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28001026/keto-analogues-and-essential-aminoacids-and-other-supplements-in-the-conservative-management-of-chronic-kidney-disease
#15
Adamasco Cupisti, Piergiorgio Bolasco
The manipulation of dietary protein intake is the mainstay of nutritional treatment of patients affected by chronic renal insufficiency, with the aim to reduce the burden of uremic toxins in order to decrease uremic toxicity and delay the need for dialysis. Consensus exists regarding the benefit of progressive protein restriction towards delaying the progression of renal failure and the need for dialysis, provided adequate energy supply. Although pivotal, protein restriction is only one aspect of the dietary management of chronic kidney disease (CKD) patients...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28001025/clinical-benefits-of-phosphate-control-in-progression-of-end-stage-renal-disease
#16
Piergiorgio Bolasco, Stefano Murtas
It is largely agreed that preservation of residual kidney function (RKF) has a directly proportional affect on general, and in particular cardiovascular, mortality. During evaluation of patients on infrequent hemodialysis (ID) as both as once-weekly or twice-weekly hemodialysis it has been frequently underestimated the importance of phosphaturia, Indeed, the native kidney preserves the ability to eliminate not only toxic molecules but also a significative output of phosphate despite of a severe decrease of RKF...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28001024/microbiota-and-prebiotics-modulation-of-uremic-toxin-generation
#17
Laetitia Koppe, Denis Fouque
Recent data have shown that the host-intestinal microbiota interaction is intrinsically linked with overall health. Chronic kidney disease (CKD) could influence intestinal microbiota and gut dysbiosis is also considered as a cause of progression of kidney disease. An increasing body of evidence indicates that dysbiosis is a key contributor of uremic retention solutes (URS) accumulating in patients with CKD. The discovery of the kidney-gut axis has created new therapeutic opportunities for nutritional intervention in order to prevent adverse outcomes...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27990791/the-role-of-carbon-adsorbent-in-the-conservative-management-of-chronic-kidney-disease
#18
Toshimitsu Niwa
Indoxyl sulfate is a uremic toxin, and cannot be removed efficiently by hemodialysis due to its protein-binding. Indoxyl sulfate induces cellular dysfunction by producing reactive oxygen species (ROS) such as superoxide by activating nicotinamide adenine dinucleotide phosphate oxidase, and by activating aryl hydrocarbon receptor through its uptake via organic anion transporters (OAT1 and OAT3). Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular cells, glomerular mesangial cells, vascular smooth muscle cells, vascular endothelial cells, cardiomyocytes, cardiac fibroblasts, monocytes, osteoblasts, osteoclasts, and myocytes...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27759735/the-role-of-low-protein-diet-in-ameliorating-proteinuria-and-deferring-dialysis-initiation-what-is-old-and-what-is-new
#19
Mengjing Wang, Jason Chou, Yongen Chang, Wei L Lau, Uttam Reddy, Connie M Rhee, Jing Chen, Chuanming Hao, Kamyar Kalantar-Zadeh
In the management of patients with chronic kidney diseases (CKD), a low-protein diet usually refers to a diet with protein intake of 0.6 to 0.8 grams per kilogram of body weight per day (g/kg/day) and should include at least 50% high-biologic-value protein. It may be supplemented with essential acids or nitrogen-free ketoanalogues if <0.6 g/kg/d. Low-protein diet can reduce proteinuria especially in non-diabetic CKD patients. In hypoalbuminemic patients it may lead to an increase in serum albumin level. By lowering proteinuria, decreasing nitrogen waste products, ameliorating metabolic burden, mitigating oxidative stress and acidosis, and lowering phosphorus burden, a low-protein diet can help delay dialysis start in advanced CKD...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28256120/prognostic-factors-in-1080-prostate-cancer-patients-treated-by-radical-external-beam-radiotherapy
#20
Elisabetta Garibaldi, Domenico Gabriele, Angelo Maggio, Elena Delmastro, Monica Garibaldi, Filippo Russo, Sara Bresciani, Michele Stasi, Pietro Gabriele
INTRODUCTION: The aim of this paper was to analyze, retrospectively, in prostate cancer patients treated in our Centre with external beam radiotherapy, the prognostic factors and their impact on the outcome in terms of Cancer Specific Survival (CSS), Biochemical Disease Free Survival (BDFS) and Clinical Disease Free Survival (CDFS). MATERIAL AND METHODS: From October 1999 and March 2012 we treated with radiotherapy, 1080 patients. Eighty-seven percent of patients were classified as < cT2, 83% had a Gleason Score (GS) < 7; the mean of iPSA was 18 ng/mL; the rate of clinical positive nodes was 1%...
March 3, 2017: Panminerva Medica
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