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Thérapie

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https://www.readbyqxmd.com/read/29128115/chronic-use-of-proton-pump-inhibitors-adverse-events-and-potential-biological-mechanisms-a-translational-analysis
#1
Farid Kheloufi, Diane Frankel, Elise Kaspi, Marion Lepelley, Michel Mallaret, Quentin Boucherie, Patrice Roll, Joelle Micallef
Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs. Even if PPI are usually considered as safe, there is a growing concern for a range of adverse effects of chronic PPI therapy often in the absence of appropriate indications. We propose, after a summary of renal, cardiovascular and neurological complications (dementia, chronic kidney disease, myocardial infarction and stroke), an integrative overview of the potential biological mechanisms involved. Eleven positive pharmacoepidemiological studies, mainly based on health insurance database linkage to hospital database, reported an increased risk of complications associated to PPI use and often a graded association suggesting also a possible dose-response relationship...
October 14, 2017: Thérapie
https://www.readbyqxmd.com/read/29126634/-antiepileptic-drugs-administration-by-nasogastric-tube-in-comatose-patients
#2
Rim Charfi, Ramla Mizouri, Mouna Ben Sassi, Emna Gaies, Hanene Eljebari, Nadia Jebabli, Sarrah Zereï, Fatma Ben Salem, Dorra Ben Said, Anis Klouz, Riadh Daghfous, Issam Salouage, Sameh Trabelsi
AIM: To evaluate the modalities of administration of antiepileptic drugs (AED) with nasogastric tube (NGT) by nurses and to draw up recommendations. METHODS: Our study consisted on investigating the modalities of administration of AED's with NGT by nurses during four months. We prepared 10 questions including demographic information. Participation was voluntary and anonymous. The questionnaire was distributed in seven intensive care departments after authorization of each head of the department...
October 12, 2017: Thérapie
https://www.readbyqxmd.com/read/29096925/-hypercalcemia-under-etanercept-treatment-what-to-consider
#3
LETTER
Clémentine Gondolf, Pauline Baudart, Sophie Fedrizzi, Christian Marcelli, Stéphane Allouche
No abstract text is available yet for this article.
October 7, 2017: Thérapie
https://www.readbyqxmd.com/read/29100610/pregnancy-outcome-following-in-utero-exposure-to-azathioprine-a-french-comparative-observational-study
#4
Zayneb Alami, Marie Sara Agier, Samir Ahid, Thierry Vial, Anne Dautriche, Laurence Lagarce, Annick Toutain, Yahia Cherrah, Annie-Pierre Jonville-Bera
AIM OF THE STUDY: To evaluate whether azathioprine exposure during pregnancy increases the risk of birth defects and prematurity. METHOD: Prospective comparative observational study using the French pregnancy database TERAPPEL. To evaluate birth defects, outcomes of pregnancies exposed to azathioprine during the 1st trimester were prospectively assessed and compared to that of pregnancies exposed to another drug used for the same indications. Secondly, the rate of preterm births was compared between fetuses exposed to azathioprine at least during the third trimester and those exposed during the first trimester only...
October 6, 2017: Thérapie
https://www.readbyqxmd.com/read/28705498/-hepatonephritis-during-the-treatment-of-malaria-by-the-therapeutic-combinations-from-a-pharmacovigilance-database
#5
Mamadou Kamagaté, Check Oumar Diallo, David Meless, Thérèse Daubrey-Potey, Augustine Kakou, Éric Balayssac, Kanga Sita N'zue, Jean Claude Yavo, Henri Die-Kakou
INTRODUCTION: Prior studies have shown an association between the onset of hepatonephritis and the use of arteminisin-based combination therapy (ACT) during the treatment of uncomplicated malaria. The objective of this study was to identify the risk factors of hepatonephritis occurrence because of the uncertainty regarding the appearance and the aggravation of this syndrome. METHODS: A case-non case study was carried out on 428 notifications of pharmacovigilance extracted from the database of the clinical pharmacology department of the teaching hospital of Cocody from 2008 to 2012...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28647106/-outpatient-consumption-of-antibiotics-with-a-bacterial-resistance-risk-in-2014-in-france
#6
Marie-Céline Casaurancq, Emilie Patras de Campaigno, Manuela Rueter, Bérangère Baricault, Robert Bourrel, Maryse Lapeyre-Mestre, Agnès Sommet
AIM: This article proposes a description of French regional consumption of antibiotics with a bacterial resistance risk (amoxicillin+clavulanic acid, third-generation cephalosporins [C3G] and fluoroquinolones). METHODS: Antibiotics reimbursements data were obtained by Open Medic website. The antibiotic consumption profile has been established using some indicators of the European Surveillance of Antimicrobial Consumption (ESAC) in daily-defined dose per 1000 inhabitants per day (DID) or in percentage...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28461037/post-marketing-drug-withdrawals-pharmacovigilance-success-regulatory-problems
#7
Jeffrey K Aronson
Modern pharmacovigilance began in the 1960s, since when the subject has grown markedly, interest having particularly increased since 2010. One index of its success is the increasing speed with which serious adverse drug reactions are discovered after marketing of a medicinal product. However, the speed with which products have subsequently been withdrawn as a result of the discovery of serious adverse reactions has not consistently changed. This highlights problems that regulators and manufacturers face when serious reactions are discovered, with difficulties in deciding which of several consequent actions to take: to add specific warnings (cautions) or contraindications to the product label; to issue a Direct Healthcare Professional Communication; to allow informed patients to decide whether they will take the drug; or, in the most serious cases, to withdraw the product or revoke the licence...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28457572/analytical-interference-during-cefepime-therapeutic-drug-monitoring-in-intensive-care-patient-about-a-case-report
#8
Laurie Toullec, Julien Dupouey, Coralie Vigne, Amélie Marsot, Laurent Allanioux, Olivier Blin, Marc Leone, Romain Guilhaumou
β-lactams therapeutic drug monitoring (TDM) appears as an essential tool to ensure the achievement of pharmacokinetic-pharmacodynamic targets and prevent induced toxicity in intensive care unit patients. Indeed, those patients exhibit important pharmacokinetic variabilities that could lead to unpredictable plasma concentrations, potentially associated with poor clinical outcome, development of antibiotic resistance or increased side effects. Here, we report the case of a 48-year-old-patient admitted to intensive care unit and treated by cefepime using TDM...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28457571/-acute-analgesic-effect-of-paracetamol-in-primary-care-incomplete-evidence
#9
Marion Gougain, Alain Moreau, Rémy Boussageon, Gisèle Pickering, François Gueyffier
This meta-analysis assessed the analgesic effect of a single oral dose of paracetamol versus placebo in adults, in primary care. Parallel randomized studies were searched on MEDLINE(®), CENTRAL(®), and EMBASE(®). We found five studies on sore throat (842 patients) and 12 studies on headache (3433 patients). None related to low back pain. Regardless of the outcome, paracetamol was superior to placebo (number need to treat [NNT]=4-5; standardized mean difference [SMD]=0.51-0.92). Additional clinical trials in other primary care conditions, like low back pain, must be conducted...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28457570/-psychoactive-effects-of-legal-high-about-lysergic-acid-amide-lsa
#10
Camille Ponté, Maryse Lapeyre-Mestre
Lysergic acid amide (LSA) is a natural psychoactive substance consumed as a psychedelic drug. In 2016, 4 cases were reported to the Toulouse Addictovigilance Centre, resulting in unintended psychic effects and led to a hospitalisation in 2 cases. Other cases of serious LSA intoxication are published, including a death. It is important to inform about the risks related to LSA consumption, a substance which is freely available and sometimes hidden behind various plant names.
October 2017: Thérapie
https://www.readbyqxmd.com/read/28416298/-epicutaneous-patch-testing-in-delayed-drug-hypersensitivity-reactions-induced-by-antiepileptic-drugs
#11
Lobna Ben Mahmoud, Najla Bahloul, Hanen Ghozzi, Brahim Kammoun, Ahmed Hakim, Zouheir Sahnoun, Sami Kammoun, Khaled Zeghal
INTRODUCTION: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. METHODS: We analyzed all cases of allergic skin reactions to antiepileptic drugs notified in regional pharmacovigilance center of Sfax (Tunisia) between June 1, 2014 and April 30, 2016...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28389014/-good-professional-practices-of-french-cics%C3%A2-%C3%A2-version-2
#12
Hugues Chevassus, Charlène Duchesne, Annabelle Sailly, Céline Vigouroux, Christine Foulon, Christine Kubiak, Christine Binquet, Alexandra Lamotte Felin, Pascal Chaud, Claire Thalamas, Catherine Cornu
French clinical investigation centers (CICs) are academic platforms dedicated to clinical research. The QUALI-CIC working group helps to improve and harmonize practices within the CIC network. After some years of implementation, the manual of good professional practices of CICs (MGPP CIC) completed in 2010, needed to be revised to best fit with the large panel of CIC activities. The aim was also to make it more accurate and to reinforce requirements about participants safety and data security. In its second version published in the present article, the MGPP CIC includes 255 items divided into 15 chapters...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28336161/-hemorrhage-treatment-evaluation-of-the-proper-use-of-fibrinogen-concentrate
#13
Jennifer Howlett, Christelle Prudent, Emmanuel De Maistre, Philippe Fagnoni, Aline Lazzarotti
An increase in fibrinogen concentrate prescriptions was noticed in 2015 after several guidelines regarding their use were published. We tried to evaluate if they were used appropriately. To evaluate the conformity of the prescriptions to these guidelines, we searched for each prescription if a dosage of blood fibrinogen was made, if its result was below the limit recommended to prescribe fibrinogen concentrate, and if the posology was in line with the recommendations. Effect and security of the treatment was also evaluated...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28336160/unexpected-drug-induced-raynaud-phenomenon-analysis-from-the-french-national-pharmacovigilance-database
#14
Émilie Bouquet, Geoffrey Urbanski, Christian Lavigne, Pascale Lainé-Cessac
OBJECTIVE: To estimate the association between exposure to medicinal products and Raynaud phenomenon. METHODS: The study used the data of all adverse drug reactions notified to the French national pharmacovigilance database. All cases reported between 1st January 1995 and 10th December 2012 were selected. A case/non-case method was used to measure disproportionality of the association between drug exposure and Raynaud phenomenon. The cases concerned all observations involving Raynaud phenomenon...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28336157/-prescription-of-acetaminophen-in-five-french-hospitals-what-are-the-practices
#15
Jean-Baptiste Pace, Viviane Nave, Mélanie Moulis, Magali Bourdelin, Sandra Coursier, Élodie Jean-Bart, Bertrand Leroy, Jean-Louis Bonnefous, Hervé Bontemps, Jérôme Coutet, Carine Eyssette, Emmanuelle Pont
AIM: Acetaminophen is widely used in hospital settings and often considered as nontoxic. We conducted a multicentric study in order to evaluate its proper use. METHOD: Prescriptions from five general hospitals were analyzed, according to dose adjustments required in renal or liver failure, weight or chronic alcoholism, determined using a literature review. Other criteria have been assessed: indication for parenteral access, accuracy of administration time and pain assessment...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28318613/latent-tuberculosis-infection-screening-prior-to-biological-treatment-in-tunisian-patients
#16
Marwa Slouma, Ines Mahmoud, Olfa Saidane, Selma Bouden, Leila Abdelmoula
OBJECTIVES: The screening of latent tuberculosis infection (LTBI) is necessary to prevent infection in patients with chronic inflammatory disease (CID) undergoing biological treatment. We aimed to assess the efficacy of LTBI screening prior to biological treatment in Tunisia, considered as a high-incidence area of active TB disease. METHODS: We conducted a retrospective study over a period of 8 years [2007-2014] including patients with chronic inflammatory rheumatism receiving biologic agents since at least 6 months...
October 2017: Thérapie
https://www.readbyqxmd.com/read/28579364/false-positive-results-in-pharmacoepidemiology-and-pharmacovigilance
#17
Julien Bezin, Pauline Bosco-Levy, Antoine Pariente
False-positive constitute an important issue in scientific research. In the domain of drug evaluation, it affects all phases of drug development and assessment, from the very early preclinical studies to the late post-marketing evaluations. The core concern associated with this false-positive is the lack of replicability of the results. Aside from fraud or misconducts, false-positive is often envisioned from the statistical angle, which considers them as a price to pay for type I error in statistical testing, and its inflation in the context of multiple testing...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28577824/-false-positive-results-or-what-s-the-probability-that-a-significant-p-value-indicates-a-true-effect
#18
Michel Cucherat, Silvy Laporte
The use of statistical test is central in the clinical trial. At the statistical level, obtaining a P<0.05 allows to claim the effectiveness of the new studied treatment. However, given its underlying mathematical logic the concept of "P value" is often misinterpreted. It is often assimilated, mistakenly, to the likelihood that treatment is ineffective. Actually the "P value" gives an indirect information about the plausibility of the existence of treatment effect. With "P<0.05", the probability that the treatment is effective may vary depending on other statistical parameters which are the alpha level of risk, the power of the study and especially the a priori probability of the existence of treatment effect...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28343650/-surveillance-system-on-drug-abuse-interest-of-the-french-national-oppidum-program-of-french-addictovigilance-network
#19
Elisabeth Frauger, Liselotte Pochard, Quentin Boucherie, Adeline Giocanti, Cécile Chevallier, Amélie Daveluy, Valérie Gibaja, Anne-Sylvie Caous, Céline Eiden, Nicolas Authier, Reynald Le Boisselier, Marylène Guerlais, Émilie Jouanjus, Marion Lepelley, Véronique Pizzoglio, Stéphanie Pain, Nathalie Richard, Joëlle Micallef
It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs and misuse of psychotropic medications') surveillance system anonymously collects information on drug abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. The aim of this article is to demonstrate the utility of OPPIDUM system using 2015 data. OPPIDUM is a cross-sectional survey repeated each year since 1995. In 2015, 5003 patients described the modality of use of 10,159 psychoactive drugs...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28341159/-effectiveness-of-preventive-treatment-by-influenzinum-in-the-winter-period-against-the-onset-of-influenza-like-illnesses
#20
Charline Marinone, Mehdi Bastard, Pierre-André Bonnet, Gaétan Gentile, Ludovic Casanova
AIM: In vitro Influenzinum induce a cellular change. We present the results of the first study examining the effectiveness of Influenzinum against influenza-like illnesses. METHOD: Retrospective cohort study during winter 2014-2015. After influenza epidemic, a self-assessment questionnaire was offered to patients presenting for a consultation. The primary endpoint was the declaration of an influenza-like illness. The exposed patients (treated by Influenzinum) were matched to two non-exposed patients (untreated) with a propensity score...
September 2017: Thérapie
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