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Thérapie

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https://www.readbyqxmd.com/read/30017376/-involvement-of-addictovigilance-in-emergency-department-for-the-detection-of-abuse-and-dependence-cases-3-years-of-experience
#1
Anaïs Serre, Céline Eiden, Vincent Gourhant, Marion Laureau, Damien Perier, Isabelle Giraud, Mustapha Sebbane, Hélène Peyrière
INTRODUCTION: Due to the increase of hospitalization at emergency department (ED) related to psychoactive substances use (PSU), the addictovigilance center of Montpellier has been integrated into the URGEIM program for the detection of iatrogenic events at the ED. The objective of the present work was to analyze spontaneous reports (SR) collected via the URGEIM program. METHODS: Analysis of spontaneous reports related to PSU at the ED of the Montpellier University Hospital, collected through the URGEIM program, between January 2014 and December 2016...
June 28, 2018: Thérapie
https://www.readbyqxmd.com/read/29980296/-ketamine-and-chronic-pain-a-narrative-review-of-its-efficacy-and-its-adverse-events
#2
Gisèle Pickering, Véronique Morel, Joelle Micallef
Ketamine is frequently used in the management of refractory chronic pain. To date, the level of proof in the literature on ketamine in this type of indication is generally poor and physicians have no consensus or recommendation to support their practice. This narrative review is an update on literature data assessing the efficacy and safety of ketamine in chronic pain. The electronic search of the Medline, PubMed, Google Scholar and Cochrane databases identified a total of 61 articles including randomized and non-randomized trials and 14 international reviews...
June 19, 2018: Thérapie
https://www.readbyqxmd.com/read/29980295/traitement-par-m%C3%A3-thotrexate-lors-d%C3%A2-une-sarco%C3%A3-dose-osseuse-digitale-multifocale%C3%A2-%C3%A3-propos-d%C3%A2-un-cas
#3
LETTER
Hana Sahli, Asma Bachali, Raja Amri, Khaled Bouzaidi, Rawdha Tekaya
No abstract text is available yet for this article.
June 19, 2018: Thérapie
https://www.readbyqxmd.com/read/29937080/-management-of-medication-errors-in-general-medical-practice-study-in-a-pluriprofessionnal-health-care-center
#4
Laure Pourrain, Michel Serin, Anne Dautriche, Fréderic Jacquetin, Christophe Jarny, Isabelle Ballenecker, Mickaël Bahous, Catherine Sgro
BACKGROUND: Medication errors are the most frequent medical care adverse events in France. Their management process used in hospital remains poorly applied in primary ambulatory care. OBJECTIVES: The main objective of our study was to assess medication error management in general ambulatory practice. The secondary objectives were the characterization of the errors and the analysis of their root causes in order to implement corrective measures. METHODS: The study was performed in a pluriprofessionnal health care house, applying the stages and tools validated by the French high health authority, that we previously adapted to ambulatory medical cares...
June 7, 2018: Thérapie
https://www.readbyqxmd.com/read/29803511/glibenclamide-induced-photodistributed-lichenoid-eruption-an-unusual-association
#5
LETTER
Zohra Chadli, Amel Chaabane, Najeh Ben Fadhl, Nadia Ben Fredj, Naceur A Boughattas, Karim Aouam
No abstract text is available yet for this article.
May 23, 2018: Thérapie
https://www.readbyqxmd.com/read/29805052/-iso-9001certification-of-a-quality-management-system-in-a-clinical-investigation-center
#6
Jimmy Chesnais, Claire Fougerou-Leurent, Claire Laforest, Alain Renault, Eric Bellissant, Bruno Laviolle
Beyond the application of legal requirements, clinical trials must have a permanent approach of quality control. The clinical investigation centers (CICs) are academic structures of clinical research certified by the French National institute of health and medical research (Inserm) and whose functioning relies on recommendations of good practice. It is important to accompany this standardization of practices by the implementation of a quality management system. This article presents the process that enabled the CIC of Rennes to become certified ISO 9001 by French standards association (Afnor) certification in May, 2016...
May 3, 2018: Thérapie
https://www.readbyqxmd.com/read/29786507/severe-acute-hepatitis-after-thymoglobulin-induction-before-islet-transplantation
#7
LETTER
Quentin Perrier, Rachel Tetaz, Magalie Baudrant, Marion Lepelley, Thierry Berney, Pierre-Yves Benhamou, Sandrine Lablanche
No abstract text is available yet for this article.
May 3, 2018: Thérapie
https://www.readbyqxmd.com/read/29921459/-satisfaction-of-a-pharmacovigilance-declaration-support-network-in-general-practice
#8
Damien Driot, Lucile Figuet, Jordan Birebent, Sandra Coste, Geneviève Durrieu, Julien Jacquot, Michel Bismuth
OBJECTIVE: General practitioners (GPs) report little adverse drug reactions (ADR), although it is mandatory in France. The objective was to evaluate the satisfaction of the GPs who participated to a pharmacovigilance ADR declaration support network via a clinical research assistant (CRA) moving to their GP office in the French South-West region of Midi-Pyrénées. STUDY DESIGN: A satisfaction questionnaire was sent to the 59 active GPs of this network in November 2016...
April 28, 2018: Thérapie
https://www.readbyqxmd.com/read/29789133/eosinophilic-pneumonia-induced-by-non-steroidal-anti-inflammatory-drugs-an-underestimated-risk
#9
François Krabansky, Brahim Azzouz, Josette Biya, Malak Abou Taam, Aurore Morel, Thierry Trenque
INTRODUCTION: Eosinophilic pneumonia (EP) is a rare but serious adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: We describe the second published case of EP induced by oral diclofenac. We also reviewed the literature as well as French pharmacovigilance database. Case presentation A 63 year-old woman with polyarthralgia had taken diclofenac for three days for analgesic purposes. Progressively, the patient presented weakness, dyspnea and fever...
April 28, 2018: Thérapie
https://www.readbyqxmd.com/read/29778305/-leukocytosis-during-pirfenidone-therapy-a-case-report
#10
LETTER
Mélanie Moltenis, Anne Gondouin, Marie-Blanche Valnet Rabier, Siamak Davani
No abstract text is available yet for this article.
April 23, 2018: Thérapie
https://www.readbyqxmd.com/read/29395300/effect-of-body-weight-and-composition-on-efavirenz-atazanavir-or-darunavir-concentration
#11
Célia Lloret-Linares, Yasmin Rahmoun, Amanda Lopes, Dorothée Chopin, Guy Simoneau, Andrew Green, Brigitte Delhotal, Hélène Sauvageon, Stéphane Mouly, Jean-François Bergmann, Pierre-Olivier Sellier
BACKGROUND: To compare the steady state plasma concentrations (Css) of three antiretroviral drugs in both normal and overweight patients, and to determine the relationship between Css and fat mass (FM) or lean body mass. METHODS: Patients treated for more than 6 months once daily with one of the antiretroviral drugs: efavirenz (EFV) 600mg, atazanavir boosted with ritonavir (ATV-r) 300mg/100mg, or darunavir boosted with ritonavir (DRV-r) 800mg/100mg, combined with two nucleoside analogues, were enrolled prospectively...
May 2018: Thérapie
https://www.readbyqxmd.com/read/29246378/-agomelatine-in-real-life-condition-a-safe-context-of-prescription-results-of-a-one-year-single-center-evaluation
#12
LETTER
Hervé Javelot, Marie Berard, Delphine Grégoire, Cathy Nonnenmacher
No abstract text is available yet for this article.
May 2018: Thérapie
https://www.readbyqxmd.com/read/29221863/-cutaneous-pigmentation-related-to-intravenous-iron-extravasation-analysis-from-the-french-pharmacovigilance-database
#13
Alexia Hermitte-Gandoliere, Nadine Petitpain, Marion Lepelley, Laure Thomas, Christine Le Beller, Jacqueline Ponte Astoul, Pierre Gillet
INTRODUCTION: Intravenous iron infusion may be complicated by extravasation and lead to cutaneous pigmentation. METHODS: We queried the French pharmacovigilance database to assess the spontaneously reported cases over the 2000-2016 period. RESULTS: Fifty-one cases of cutaneous pigmentation related to intravenous iron extravasation were retrieved, none was associated to necrosis. Most of patients were women aged 20 to 49 years old. The pigmentation was mostly a brown coloration, persisting over one month in 19 cases (37...
May 2018: Thérapie
https://www.readbyqxmd.com/read/29203065/-severe-ipilimumab-induced-ulcerative-colitis-remitting-after-infliximab-therapy-and-secondary-switching-with-pembrolizumab
#14
LETTER
Mélissa Yelehe-Okouma, Florence Granel-Brocard, Hervé Hudziak, Jean-Luc Schmutz, Pierre Gillet
No abstract text is available yet for this article.
May 2018: Thérapie
https://www.readbyqxmd.com/read/29198734/-clinical-research-and-data-collection-during-the-investigation-influence-of-a-dedicated-staff
#15
Sabine Ghenim, Thomas Féron, Coralie Barbe, Aurore Wolak-Thierry, Damien Jolly
OBJECTIVE: In clinical research, the recourse to a staff dedicated as CRA with the investigator is common practice to facilitate the work of collection and limiting the missing data (MD). We, therefore, looked for the interest of the recourse of such personnel to data collection. METHODS: MD were classified according to five categories: clinical, para-clinical, treatment, adverse events (serious) and others. Studies were separated in two designs, one-off studies during a single visit (so-called "no follow") and studies on the duration and including several visits (say "with follow")...
May 2018: Thérapie
https://www.readbyqxmd.com/read/29195714/-gastric-acid-rebound-after-a-proton-pump-inhibitor-narrative-review-of-literature
#16
Michaël Rochoy, Sébastien Dubois, Raymond Glantenet, Sophie Gautier, Marc Lambert
BACKGROUND: Since the introduction of the first proton pump inhibitor (PPI) 20 years ago, studies have examined the presence of a rebound effect when this treatment is discontinued. These studies are heterogeneous and contradictory: the last literature review on the rebound in gastric acidity dates from 2006 and did not allow to conclude on the subject. Our objective was to carry out an up-to-date literature review on the existence and characteristics of this gastric acid rebound at the end of PPIs...
May 2018: Thérapie
https://www.readbyqxmd.com/read/29195713/generic-antiretroviral-drug-use-in-hiv-infected-patients-a-cohort-study-from-the-french-health-insurance-database
#17
Joseph Rwagitinywa, Maryse Lapeyre-Mestre, Robert Bourrel, Agnès Sommet
OBJECTIVE: This study aimed to estimate the rate of generic users among HIV-infected patients treated by antiretroviral (ARV) drugs potentially substitutable and to determine factors associated with switch from brand to generic ARV in real-life settings in a French region. METHODS: Cohort of HIV-infected patients aged of ≥18 years, exposed to at least one of the generic of lamivudine (3TC-150mg/300mg), zidovudine/lamivudine (AZT-200mg/3TC-150mg), nevirapine (NVP-200mg), efavirenz (EFV-600mg) and those exposed to brand 3TC, AZT/3TC, NVP, EFV, the fixed-dose combination abacavir/lamivudine (ABC/3TC) or the single-tablet regimen efavirenz/emtricitabine/tenofovir (EFV/FTC/TDF) as recorded in the French health insurance database between January 2012 and May 2015 were included...
May 2018: Thérapie
https://www.readbyqxmd.com/read/29174956/pristinamycin-induced-leukocytoclastic-vasculitis-first-report-of-a-case-in-tunisia
#18
LETTER
Chayma Ladhari, Amina Aounallah, Raoudha Slim, Neila Fathallah, Badreddine Sriha, Souheil Chati, Mohamed Denguezli, Chaker Ben Salem
No abstract text is available yet for this article.
May 2018: Thérapie
https://www.readbyqxmd.com/read/29174397/-case-non-case-studies-principles-methods-bias-and-interpretation
#19
Jean-Luc Faillie
Case-non case studies belongs to the methods assessing drug safety by analyzing the disproportionality of notifications of adverse drug reactions in pharmacovigilance databases. Used for the first time in the 1980s, the last few decades have seen a significant increase in the use of this design. The principle of the case-non case study is to compare drug exposure in cases of a studied adverse reaction with that of cases of other reported adverse reactions and called "non cases". Results are presented in the form of a reporting odds ratio (ROR), the interpretation of which makes it possible to identify drug safety signals...
May 2018: Thérapie
https://www.readbyqxmd.com/read/29169862/letter-to-the-editor-concerning-the-adverse-health-effects-in-children-exposed-in-utero-to-diethylstilbestrol
#20
LETTER
Wienia Czarlewski
No abstract text is available yet for this article.
May 2018: Thérapie
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