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Thérapie

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https://www.readbyqxmd.com/read/28822583/-misuse-and-adverse-effects-of-new-direct-oral-anticoagulants-a-prospective-observational-study-in-patients-admitted-to-an-emergency-unit-of-a-french-university-hospital
#1
Thomas Lafon, Christine Vallejo, Mathilde Hadj, Marie-Laure Laroche, Hélène Geniaux
INTRODUCTION: The use of direct oral anticoagulants (NOAC) is complex: indications, dosage adjustments and precautions. Emergency departments (ED) are increasingly faced with patients receiving NOAC. The aim of this study was to evaluate the misuse and the adverse effects (AE) of NOAC. METHODS: All subjects with NOAC admitted to the Limoges University Hospital ED from 1/8/2013 to 1/4/2014 were included in a prospective observational study. Misuse was identified from the NOAC summary of product characteristics and from the 2014 ANSM guideline (indication, dose, co-medications, age, hepatic and renal function); adverse effects were recorded...
July 19, 2017: Thérapie
https://www.readbyqxmd.com/read/28823607/answer-to-ucb-letter-to-the-editor-concerning-adverse-health-effects-in-children-of-women-exposed-in-utero-to-diethylstilbestrol-des
#2
LETTER
Michel Tournaire, Emmanuel Devouche, Sylvie Epelboin
No abstract text is available yet for this article.
July 18, 2017: Thérapie
https://www.readbyqxmd.com/read/28826889/-increased-qt-interval-due-to-antiandrogenic-therapy-majorated-by-psychotropic-drugs-about-one-case
#3
LETTER
Edwige Heitzmann, Charlotte Muller, Martine Tebacher, Bruno Michel, Hervé Javelot
No abstract text is available yet for this article.
July 16, 2017: Thérapie
https://www.readbyqxmd.com/read/28802514/third-nerve-palsy-after-influenza-vaccination-in-inflammatory-bowel-disease-ibd
#4
LETTER
Frank Rouby, Farid Kheloufi, Joëlle Micallef
No abstract text is available yet for this article.
July 16, 2017: Thérapie
https://www.readbyqxmd.com/read/28800836/-convulsions-associated-with-neocodion-%C3%A2-abuse-codeine-camphosulfonate-sulfogaiacol-grindelia-extract
#5
LETTER
Bruno Revol, Hannah-Marie Doudoux, Nathalie Fouilhé Sam-Laï, Michel Mallaret
No abstract text is available yet for this article.
July 16, 2017: Thérapie
https://www.readbyqxmd.com/read/28780021/-comparative-relevance-of-declaration-of-side-effects-by-patients-and-health-professionals
#6
Audrey Lagneau, Caroline Vigier, Alexandre Marianna, Rachel Serfaty, Fanny Rocher, Anne Spreux, Milou-Daniel Drici
INTRODUCTION: Drug-induced adverse events have been accessible to patient's spontaneous reporting in France and such notifications have been steadily increasing since 2011. However, these notifications are still shrouded with medical perplexity and are sometimes subjected to partial caution in their interpretation by the patient's physician. We aimed to evaluate and compare prospectively the relevance of such spontaneous notifications with those provided by healthcare professionals to the French Pharmacovigilance Center of Nice-Alpes-Côte d'Azur...
July 8, 2017: Thérapie
https://www.readbyqxmd.com/read/28755832/-serious-adverse-drug-reactions-with-tramadol-reported-to-the-french-pharmacovigilance-database-between-2011%C3%A2-and-2015
#7
Florence Moulis, Vanessa Rousseau, Delphine Abadie, Kamel Masmoudi, Joëlle Micallef, Caroline Vigier, Sabrina Pierre, Anne Dautriche, François Montastruc, Jean-Louis Montastruc
BACKGROUND: Tramadol is an opioid and a serotonin reuptake inhibitor drug. It is approved for moderate to severe pain in adults. The aim of this study was to assess tramadol safety through a national pharmacovigilance study in France since dextropropoxyphen withdrawal in 2011. METHODS: We described all serious adverse drug reactions (SADRs) reported with tramadol in adults in the French National PharmacoVigilance Database from August 1st, 2011 to December 31st, 2015...
June 29, 2017: Thérapie
https://www.readbyqxmd.com/read/28579364/false-positive-results-in-pharmacoepidemiology-and-pharmacovigilance
#8
Julien Bezin, Pauline Bosco-Levy, Antoine Pariente
False-positive constitute an important issue in scientific research. In the domain of drug evaluation, it affects all phases of drug development and assessment, from the very early preclinical studies to the late post-marketing evaluations. The core concern associated with this false-positive is the lack of replicability of the results. Aside from fraud or misconducts, false-positive is often envisioned from the statistical angle, which considers them as a price to pay for type I error in statistical testing, and its inflation in the context of multiple testing...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28577824/-false-positive-results-or-what-s-the-probability-that-a-significant-p-value-indicates-a-true-effect
#9
Michel Cucherat, Silvy Laporte
The use of statistical test is central in the clinical trial. At the statistical level, obtaining a P<0.05 allows to claim the effectiveness of the new studied treatment. However, given its underlying mathematical logic the concept of "P value" is often misinterpreted. It is often assimilated, mistakenly, to the likelihood that treatment is ineffective. Actually the "P value" gives an indirect information about the plausibility of the existence of treatment effect. With "P<0.05", the probability that the treatment is effective may vary depending on other statistical parameters which are the alpha level of risk, the power of the study and especially the a priori probability of the existence of treatment effect...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28343650/-surveillance-system-on-drug-abuse-interest-of-the-french-national-oppidum-program-of-french-addictovigilance-network
#10
Elisabeth Frauger, Liselotte Pochard, Quentin Boucherie, Adeline Giocanti, Cécile Chevallier, Amélie Daveluy, Valérie Gibaja, Anne-Sylvie Caous, Céline Eiden, Nicolas Authier, Reynald Le Boisselier, Marylène Guerlais, Émilie Jouanjus, Marion Lepelley, Véronique Pizzoglio, Stéphanie Pain, Nathalie Richard, Joëlle Micallef
It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs and misuse of psychotropic medications') surveillance system anonymously collects information on drug abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. The aim of this article is to demonstrate the utility of OPPIDUM system using 2015 data. OPPIDUM is a cross-sectional survey repeated each year since 1995. In 2015, 5003 patients described the modality of use of 10,159 psychoactive drugs...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28341159/-effectiveness-of-preventive-treatment-by-influenzinum-in-the-winter-period-against-the-onset-of-influenza-like-illnesses
#11
Charline Marinone, Mehdi Bastard, Pierre-André Bonnet, Gaétan Gentile, Ludovic Casanova
AIM: In vitro Influenzinum induce a cellular change. We present the results of the first study examining the effectiveness of Influenzinum against influenza-like illnesses. METHOD: Retrospective cohort study during winter 2014-2015. After influenza epidemic, a self-assessment questionnaire was offered to patients presenting for a consultation. The primary endpoint was the declaration of an influenza-like illness. The exposed patients (treated by Influenzinum) were matched to two non-exposed patients (untreated) with a propensity score...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28341158/letter-to-the-editor-concerning-the-cancer-risk-in-women-exposed-to-diethylstilbestrol-in-utero
#12
LETTER
Wienia Czarlewski
No abstract text is available yet for this article.
September 2017: Thérapie
https://www.readbyqxmd.com/read/28341157/answer-to-ucb-letter-to-the-editor-concerning-cancer-risk-in-women-exposed-to-diethylstilbestrol-in-utero
#13
LETTER
Michel Tournaire, Émmanuel Devouche, Sylvie Epelboin
No abstract text is available yet for this article.
September 2017: Thérapie
https://www.readbyqxmd.com/read/28336159/the-anticholinergic-impregnation-scale-towards-the-elaboration-of-a-scale-adapted-to-prescriptions-in-french-psychiatric-settings
#14
Jeanne Briet, Hervé Javelot, Edwige Heitzmann, Luisa Weiner, Catherine Lameira, Philippe D'Athis, Marie Corneloup, Jean-Louis Vailleau
PURPOSE: Some drugs have anticholinergic activity and can cause peripheral or central side effects. Several scales exist to evaluate the potential anticholinergic effect of prescribed drugs but: (i) they are validated in the elderly and mainly assess the cognitive side effect of treatments; (ii) they do not concern some of the drugs frequently used in clinical psychiatry in France. The aim of our study is to develop a new scale, the anticholinergic impregnation scale (AIS), with drugs used in France and based on an assessment of the drugs used against peripheral anticholinergic adverse effects...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28336158/-acetaminophen-knowledge-use-and-overdose-risk-in-urban-patients-consulting-their-general-practitioner-a-prospective-descriptive-and-transversal-study
#15
Lauriane Cipolat, Ouriel Loeb, Clotilde Latarche, Elise Pape, Pierre Gillet, Nadine Petitpain
INTRODUCTION: Acetaminophen is the most involved active substance in both unintentional and intentional drug poisoning. However, its availability outside community pharmacies is being debated in France. METHODS: We made, via a self-administered questionnaire, a prospective assessment of knowledge, use and acetaminophen overdose risk in patients consulting their general practitioner, in the Metz Métropole urban area, between May 2015 and February 2016. We estimated the prevalence of potential unintentional overdosage by capture-recapture method...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28318612/-bcgitis-an-unusual-complication-after-intravesical-immunotherapy
#16
LETTER
Pierrick Le Borgne, Claudia Brunhuber, Florent Baicry, Carine Zumstein, Mickael Forato, Pascal Bilbault
No abstract text is available yet for this article.
September 2017: Thérapie
https://www.readbyqxmd.com/read/28318611/-docamed-smartphone-app-internet-website-on-medicines-and-their-therapeutic-indications
#17
Philippe Lechat, Sophie Ravoire
No abstract text is available yet for this article.
September 2017: Thérapie
https://www.readbyqxmd.com/read/28258721/cancer-genomics-guide-clinical-practice-in-personalized-medicine
#18
Jacqueline Lehmann-Che, Brigitte Poirot, Jean-Christophe Boyer, Alexandre Evrard
Targeted therapies have revolutionized the treatment of many cancers. Widely developed over the last decade, this new concept of precision medicine relies on the use of genomic technologies to analyze tumor samples in order to identify actionable targets and biomarkers of resistance. The goal is to optimize treatment by identifying which therapeutic approach is best for each patient, i.e. the treatment that is effective, has minimal adverse effects, and avoids unnecessary intervention and cost. The purpose of this review is to highlight, using a few seminal examples of therapeutic targets, the important contribution of appropriate analysis of key oncogenes or driver genes in making clinical decisions...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28214069/-pharmacokinetic-drug-interaction-between-miconazole-mucoadhesive-tablet-and-tacrolimus-about-3%C3%A2-case-reports-in-transplant-patients
#19
Marion Lepelley, Sophie Logerot, Xavier Fonrose, Céline Villier
Loramyc(®) is a mucoadhesive tablet of miconazole, indicated for the treatment of oropharyngeal candidiasis in immunocompromised patients. Miconazole, as others azole antifungals, is known for its potent inhibitory properties of cytochromes P450 enzymes and P-glycoprotein (P-gp). Inhibition of cytochromes P450 enzymes and P-gp can produce pharmacokinetic drug interaction. Immunosuppressive agents, such as calcineurin inhibitors (tacrolimus, cyclosporine) are substrates of cytochromes P450 3A4 and P-gp. Nevertheless, the impact of systemic absorption of miconazole mucoadhesive tablet has not been investigated by the laboratory before regulatory approval...
September 2017: Thérapie
https://www.readbyqxmd.com/read/28214068/-a-first-case-of-cerebellar-syndrome-due-to-fluoroquinolone
#20
LETTER
Abrar-Ahmad Zulfiqar
No abstract text is available yet for this article.
September 2017: Thérapie
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