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Stéphanie Pain, François Chavant, Bernard Fauconneau, Jérémy Guenezan, Nicolas Marjanovic, Jean-Yves Lardeur, Bertrand Brunet, Marie-Christine Perault-Pochat
"Poppers" (alkyl nitrites) were made famous in the 1960s as a party drug and are still used today. They are highly volatile, sweet-smelling liquids commonly administered by inhalation. However, sometimes, they can be consumed by oral ingestion resulting in greater toxicity. They are used for their vasodilator effects but these volatile nitrites can also cause methemoglobinemia. Methemoglobinemia is a rare pathology that results from the oxidation of iron in the hemoglobin molecule. Oxidation of iron switches it from the ferrous to the ferric state and impedes the ability of hemoglobin to carry oxygen...
December 2, 2016: Thérapie
Sana Mokni, Nadia Fetoui Ghariani, Amina Aounallah, Neila Fathallah, Lobna Boussofara, Wafa Saidi, Chaker Ben Salem, Badreddine Sriha, Colendane Belajouza, Mohamed Denguezli, Najet Ghariani, Rafiaa Nouira
Hydroxyurea (HU) is an antitumor agent used to treat myeloproliferative syndromes. HU is usually well tolerated but many dermatological complications have been reported during long-term HU therapy. We describe the case of a patient who developed manydermatological side effects of long-term hydroxyurea therapy, in particularly a squamous cell carcinoma and dermatomyosite-like eruption.
November 10, 2016: Thérapie
Geneviève Durrieu, Julien Jacquot, Dominique Baudrin, Mathilde Mège, Vanessa Rousseau, Haleh Bagheri, Emmanuelle Bondon-Guitton, Delphine Abadie, François Montastruc, Michel Bismuth, Stéphane Oustric, Jean-Louis Montastruc
The main limitation of adverse drug reactions (ADRs) reporting, particularly by general practitioners (GP), to the regional pharmacovigilance centers is under-reporting. The Midi-Pyrénées Regional Pharmacovigilance Center (South western, France) sets up regular visits by a clinical research assistant (CRA) to GP in order to increase the number of ADR reports. The aim of this pilot study was to assess the effect of regular visits of a CRA in GPs offices on the rate of ADR reporting. After one year, CRA visits permit a two-fold increase in ADR reporting...
October 27, 2016: Thérapie
Mathilde Salgues, Christine Damase-Michel, Jean-Louis Montastruc, Isabelle Lacroix
Many trials have shown that folic acid supplementation before and during pregnancy reduces the risk of neural tube defects in general population. We investigated the knowledge of folic acid in women of child-bearing age. Women of child-bearing age were interviewed by 20 pharmacists living in Haute-Garonne between January and February 2014. One hundred ninety-six women were included in the present study. Out of them, 36% of women never heard of folic acid and 82% were not aware of its benefits. Knowledge was higher in older women, women in a couple and women with higher educational level (P<10(-2))...
October 27, 2016: Thérapie
Zoubir Djerada, Georges Brousse, Philippe Niel, Pierre-Michel Llorca, Alain Eschalier, Danièle Bentue-Ferrer, Fréderic Libert
Olanzapine, atypical antipsychotic, is used to treat schizophrenia and bipolar disorder. Its therapeutic drug monitoring (TDM) is quite commonly done. Olanzapine is well absorbed orally (bioavailability: 85 %), with peak plasma occurring between 4 and 6hours after oral administration. It is extensively metabolized by different hepatic enzymes (including CYP1A2 and CYP2D6 isoforms) to a large number of inactive metabolites, and its half-life is between 30 and 60hours. No specific therapeutic range, or threshold concentration could not be a consensus, but the higher intra- and interindividual variability, as well as the existence of studies suggesting a correlation between circulating concentrations of olanzapine and occurrence of therapeutic relapse or toxic phenomena appear to justify the STP for this molecule...
October 25, 2016: Thérapie
Pierre-Géraud Claret, Xavier Bobbia, Rhoda Renia, Andrew Stowell, Jacques Crampagne, Jean Flechet, Christian Czeschan, Mustapha Sebbane, Paul Landais, Jean-Emmanuel de La Coussaye
OBJECTIVES: Adverse drug events are the sixth-leading cause of death in Western countries and are also more frequent in emergency departments (EDs). In some hospitals or on some occasions, ED physicians prescribe for patients who they have admitted. These prescriptions are then followed by the wards and can persist for several days. Our objectives were to determine the frequency of prescription errors for patients over 18years old hospitalized from ED to medical or surgical wards, and whether there exists a relationship between those prescription errors and ED LOS...
October 25, 2016: Thérapie
Ons Charfi, Ghozlane Lakhoua, Rym Sahnoun, Sihem El Aidli, Riadh Daghfous, Sarrah Kastalli, Ahmed Zaïem
No abstract text is available yet for this article.
October 19, 2016: Thérapie
Aurélie Morand, Vincent Barlogis, Frank Rouby, Rachel Reynaud, Céline Marrec, Gérard Michel
No abstract text is available yet for this article.
October 19, 2016: Thérapie
Elodie Farnier, Nicolas Charhon, Laurence Papillon, Michel Tod
No abstract text is available yet for this article.
October 19, 2016: Thérapie
Sandra Nordmann, Thomas Nefau, Joëlle Micallef, Catherine Duplessy, Jean-Christophe Catusse, Elisabeth Frauger
OBJECTIVE: The aim of this study is to analyze the residual content of used syringes. METHODS: Used syringes were collected in March 2014 at 9 sites in Marseille (automatic injection kit dispensers, streets, drug-user risk reduction centers [Centres d'accueil et d'accompagnement à la réduction de risques pour usagers de drogues [CAARUD]). Several substances (n=28) were investigated using liquid chromatography and mass spectrometry method. RESULTS: On average, 2±1 substances in each syringe were found among 254 syringes analyzed...
October 19, 2016: Thérapie
Inès Masmoudi, Valérie Gras-Champel, Dominique Barbieux-Vaquez, Kamel Masmoudi
Pregabalin is not known to induce parkinsonism, one single case is published in the literature. In this work, we report the second case of parkinsonism-induced by this drug in a 58-year old woman initially dosed at 600mg daily for 3 years which was reduced to 300mg daily after the onset of myoclonic jerks and especially because of a weight gain. She is regularly monitored by a neurologist who notes the onset of a parkinsonian syndrome whose asymmetry clinical picture mimicking an idiopathic Parkinson's disease but positron emission tomography (PET scan) was normal and the brain magnetic resonance imaging MRI found a banal leukopathy...
October 15, 2016: Thérapie
Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier, Frédéric Barbot, Alain Leizorovicz, Nadine Juge, Céline Giraud, François Gueyffier, Alexandra Félin, Thibault Mura, Hugues Chevassus, Christine Binquet
CONTEXT: Clinical studies involve an increasing amount of data collection and management. However, there is no specific quality standard sufficiently practical, in free access, and open for data management and the underlying IT-infrastructure in academic units. European Clinical Research Infrastructures Network (ECRIN) published standard requirements for certified data management units. We present a French version of these standards. METHODS: A group of experts produced the standards, by consensus...
October 13, 2016: Thérapie
Joachim Alexandre, Xavier Humbert, Marion Sassier, Alexandre Cesbron, Cécile Le Naourès, Véronique Pottier, Paolo-Emilio Puddu, Paul Milliez, Antoine Coquerel, Sophie Fedrizzi
No abstract text is available yet for this article.
October 8, 2016: Thérapie
Marie Kostine, Nadia Mehsen-Cetre, Bernard Bannwarth
Paget's disease of bone is characterised by focal areas of increased bone turnover affecting one or several bones throughout the skeleton. Where indicated, pharmacological management is primarily based on the use of anti-resorptive drugs. In this respect, bisphosphonates are the drugs of choice. However, they are contraindicated in patients with advanced renal dysfunction. Here, we report the efficacy and safety of one denosumab injection (60mg) in a patient with Paget's disease of bone and impaired renal function, who benefited from this treatment but developed a severe hypocalcemia...
September 15, 2016: Thérapie
Edouard-Jules Laforgue, Samuel Bulteau, Jennyfer Cholet, Caroline Victorri-Vigneau, Marie Guitteny, Nicolas Mauduit, Jean-Marie Vanelle, Anne Sauvaget
PURPOSE: There are differences between recommendations and practice in the pharmacological treatment of acute mania. OBJECTIVE: The objective was to assess conformity of the anti-manic prescription between national recommendations (Haute Autorité de santé [French health authority, HAS] and "résumé des caractéristiques du produit" [product characteristics, RCP]) and clinical practice. METHODS: We observed the drug prescriptions of in-patients for a manic episode...
September 15, 2016: Thérapie
Charles Khouri, Marion Lepelley, Céline Villier, Thierry Bougerol, Michel Mallaret
PURPOSE: Cyamemazine (Tercian(®)) is currently the most widely prescribed neuroleptic in France. This widespread use is due to its anxiolytics properties and to a claimed good safety profile. Although, prescription of cyamemazine is not devoid of the risks associated with the use of neuroleptics: extrapyramidal syndromes. This study aims at describing extrapyramidal syndromes induced by cyamemazine registered in the French pharmacovigilance database. METHODS: All spontaneous reports of extrapyramidal syndromes in the French pharmacovigilance database between 1st January 1985 and 31th December 2015 were described and analyzed...
September 15, 2016: Thérapie
Pascale Gisquet-Verrier, Daniel Tolédano, Claire Le Dorze
Post-traumatic stress disorder (PTSD) and addiction to drugs of abuse are two common diseases, showing high comorbidity rates. This review presents a number of evidence showing similarities between these two pathologies, especially the hyper-responsiveness to environmental cues inducing a reactivation of the target memory leading either to re-experiencing (PTSD), or drug craving. Accordingly, PTSD and addiction to drug of abuse might by considered as memory pathologies, underlined by the same physiological process...
September 15, 2016: Thérapie
Neila Fathallah, Chayma Ladhari, Raoudha Slim, Najet Ghariani, Badreddine Sriha, Chaker Ben Salem
Drug-associated immune-complex vasculitis induced by antiepileptics is a rare adverse drug reaction, more frequently reported with carbamazepine, valproic acid and phenytoin. Phenobarbital has not been previously reported to induce vasculitis. We report a cutaneous vasculitis induced by phenobarbital with cross-reactivity to carbamazepine in an 18-year-old epileptic patient. Carbamazepine and phenobarbital are both aromatic antiepileptic drugs with similarity in their chemical structure. Cross-reactivity is a frequently reported effect between these drugs following adverse skin reactions...
September 15, 2016: Thérapie
Ghozlane Lakhoua, Ahmed Zaiem, Rym Sahnoun, Sihem El Aidli, Ryadh Daghfous, Sarrah Kastalli
No abstract text is available yet for this article.
October 2016: Thérapie
Joëlle Micallef, Michel Mallaret
Based on recommendations from the World Health Organization (WHO), the French addictovigilance network was set up since 1990, in order to assess and to monitor the potential for abuse and dependence of psychoactive substances. This network composed of 13 addictovigilance centers implemented in medical pharmacology departments of French university hospitals has developed specific pharmacoepidemiological tools repeated each year so as to lead us to updated pharmacological indicators related to drug abuse. As a single source may not be informative enough, the French addictovigilance network consider simultaneously a range of indicators focusing on health insurance database, health professional sentinel networks, characteristics of psychotropic consumptions and analysed them from a medical and pharmacological point of view combined to pharmacodynamic and pharmacokinetic data...
September 2016: Thérapie
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