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https://www.readbyqxmd.com/read/30392702/french-administrative-health-care-database-snds-the-value-of-its-enrichment
#1
Lucie-Marie Scailteux, Catherine Droitcourt, Frédéric Balusson, Emmanuel Nowak, Sandrine Kerbrat, Alain Dupuy, Erwan Drezen, André Happe, Emmanuel Oger
SNIIRAM/SNDS, the French administrative health care database, covers around 99% of the population. Its main limitation is the absence of clinical information and biological results. This report exposes the value of SNIIRAM/SNDS enrichment by external databases, and the linkage issues. It is illustrated by examples: the well-known population-based cohort CONSTANCES created to answer to epidemiological research questions with a specific interest on occupational and social factors, chronic diseases, and aging; the CANARI study, a regional-based study that collected Gleason score in all pathology laboratories in Brittany and then, linked pathology results to an ad hoc extraction from SNIIRAM database; the goal was to investigate the risk of high grade prostate cancer in patients treated by 5-alpha-reductase inhibitors for a symptomatic benign prostatic hyperplasia; the SACHA study, that identified and medically validated major bleeding event referred to emergency wards, then linked those clinical data to SNIIRAM; the goal was to minimize misclassification bias when estimating bleeding risk in patients who were prescribed antithrombotic drugs; the ISO-PSY study linked the SNIIRAM with the national cause of death registry (CépiDc) and the nationwide emergency department surveillance system (OSCOUR® network) to investigate the potential link between isotretinoin and suicidal risk; the EFEMERIS cohort that assesses drugs prescriptions in French pregnant women who delivered in the Haute-Garonne region; the EPI-GETB-AM study that derived a SNIIRAM/SNDS-based algorithm to identify venous thromboembolism and linked SNIIRAM/SNDS to the EPI-GETBO-III survey for validation...
October 25, 2018: Thérapie
https://www.readbyqxmd.com/read/30392701/a-history-of-pharmacoepidemiology
#2
Bernard Bégaud
Pharmacoepidemiology, in the sense of the study of the reciprocal interactions between drugs and populations, was probably conceived far before being named so. However, the modern era started in 1985 with the birth of the International society of pharmacoepidemiology and the development of specific methodological approaches and large databases. This advent of pharmacoepidemiology resulted from a long period where the actual target of medicines, i.e., patients in real-life settings, was not considered, the truth being provided solely by pre-approval or peri-approval clinical trials...
October 19, 2018: Thérapie
https://www.readbyqxmd.com/read/30392699/interest-of-pharmacoepidemiology-for-the-study-of-inhaled-drugs
#3
Mathieu Molimard, Pierre-Olivier Girodet, Eric Van Ganse
Pharmacoepidemiology studies are of particular interest in the respiratory field and especially for inhaled drugs. In real-life, excessive use of rescue medications and under- or inappropriate-prescribing of preventer medications has been shown. In asthma and chronic obstructive pulmonary disease (COPD), the poor use of inhalation device is associated with uncontrolled diseases and occurrence of exacerbations. Inhalation treatments are directly delivered within the lung and are generally considered as safe...
October 19, 2018: Thérapie
https://www.readbyqxmd.com/read/30392700/-identification-of-abuse-dependence-cases-by-the-french-addictovigilance-network-fan-a-pilot-study-of-the-addictovigilance-center-and-the-psychotherapeutic-center-of-nancy-france
#4
Pauline Barberot, Valérie Gibaja, Célia Benkhedda, Daniela Dobre, Juliana Tournebize, Jean-Pierre Kahn
OBJECTIVES: France is the only European country with a dedicated addictovigilance network (French addictovigilance network [FAN]). However, the reporting of cases of abuse/dependence is insufficient. In an attempt to overcome this under-reporting, data from the medical information systems program (PMSI) is regularly used to identify cases. Since addictions are frequently associated with psychiatric comorbidities, a pilot study was conducted for the first time in a psychiatric hospital...
October 13, 2018: Thérapie
https://www.readbyqxmd.com/read/30389102/what-is-pharmacoepidemiology-definition-methods-interest-and-clinical-applications
#5
Jean-Louis Montastruc, Justine Benevent, François Montastruc, Haleh Bagheri, Fabien Despas, Maryse Lapeyre-Mestre, Agnès Sommet
Clinical evaluation of drugs before approval is based on the experimental design of clinical trial with randomization of drug exposure. Unfortunately, conclusions of clinical trials are necessarily limited to patients included into the trials. It is thus necessary to compare these experimental data coming from clinical trials with the real use of drugs in clinical practice. Pharmacoepidemiology is the study of interactions between drugs and human populations, investigating, in real conditions of life, benefits, risks and use of drugs...
October 10, 2018: Thérapie
https://www.readbyqxmd.com/read/30337087/-benzodiazepines-cognitive-decline-and-dementia-a-review-of-causality-criteria-from-published-observational-studies
#6
Maryse Lapeyre-Mestre
OBJECTIVE: Benzodiazepines are a source of well-known adverse reactions related to their pharmacological properties: memory disorders, falls in the elderly, confusion and sedation, drug addiction. The impact of their chronic use on cognitive decline and dementia has been the subject of many studies for two decades. METHODS: From 25 studies identified in the international literature from 1997 to 2017, the Bradford-Hill causality criteria were systematically applied...
October 3, 2018: Thérapie
https://www.readbyqxmd.com/read/30401472/anaphylactic-shock-secondary-to-oral-ofloxacin-administration-with-cross-reactivity-to-levofloxacin-and-ciprofloxacin
#7
LETTER
Bouraoui Ouni, Neila Fathallah, Raoudha Slim, Afra Brahim, Chaker Ben Salem
No abstract text is available yet for this article.
December 2018: Thérapie
https://www.readbyqxmd.com/read/29699710/-understanding-the-distrust-towards-the-assessment-of-medicines-beyond-conflict-of-interests
#8
Virginie Tournay, Antoine Pariente
This article aims at analyzing mechanisms leading to a situation of mistrust about the scientific evaluation of the medicinal product, beyond issues related to links of interests. The assumption is that conflicts of interest are only one component of this mistrust. It doesn't explain all social controversies affecting this sector, in particular the credibility of drug evaluation systems. We explore here how, during the six stages of certification that characterize the trajectory of the drug and its evaluation - the functioning of scientific production and collective representations contribute to this mistrust...
September 2018: Thérapie
https://www.readbyqxmd.com/read/29625706/pharmaceutical-cognitive-doping-in-students-a-chimeric-way-to-get-a-head
#9
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the pressing demands for memorization, top-level performance, and peer competition create an environment favorable for pharmaceutical cognitive doping behavior. We aimed to describe recent practices and the benefit/risk ratio of such behavior and to discuss the issues at stake. The prevalence of pharmaceutical cognitive doping among students has been reported from 1.3% to 33% across studies, with variations depending on country and definition of pharmaceutical cognitive doping. The therapeutic classes most frequently cited as being diverted for doping purposes are psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
September 2018: Thérapie
https://www.readbyqxmd.com/read/29486927/beware-of-an-allergic-reaction-in-stented-patients-amoxicillin-clavulanic-acid-anaphylaxis-associated-with-fatal-kounis-syndrome-and-stent-thrombosis
#10
LETTER
Ioanna Koniari, Nicholas G Kounis, Sophia N Kouni, Grigorios Tsigkas, George Soufras, George Hahalis
No abstract text is available yet for this article.
September 2018: Thérapie
https://www.readbyqxmd.com/read/29415804/answer-to-letter-to-the-editor-concerning-beware-of-an-allergic-reaction-in-stented-patients
#11
LETTER
Issam Salouage
No abstract text is available yet for this article.
September 2018: Thérapie
https://www.readbyqxmd.com/read/29395301/intravenous-amiodarone-induced-acute-liver-failure-in-cardiac-surgery-intensive-care-unit
#12
LETTER
Florence Nicot, Niki Procopi, Lee S Nguyen
No abstract text is available yet for this article.
September 2018: Thérapie
https://www.readbyqxmd.com/read/29373131/-rheumatoid-arthritis-and-polycythemia-vera-jak2-negative-association-polycythemia-may-be-worsening-under-methotrexate
#13
LETTER
Olfa Saidane, Meriem Sellami, Ines Mahmoud, Aicha Ben Tekaya, Rawdha Tekaya, Leila Abdelmoula
No abstract text is available yet for this article.
September 2018: Thérapie
https://www.readbyqxmd.com/read/29373130/hypersensitivity-to-levothyroxine-a-case-report-of-a-successful-oral-desensitization
#14
LETTER
Najla Bahloul, Lobna Ben Mahmoud, Hanen Ghozzi, Feten Hadjkacem, Khaled Zeghal, Mohamed Abid, Samy Kammoun
No abstract text is available yet for this article.
September 2018: Thérapie
https://www.readbyqxmd.com/read/29366501/-muscle-pain-and-statin-pharmacological-or-nocebo-effect
#15
LETTER
Charles Khouri, Marion Lepelley, Michel Mallaret, Matthieu Roustit, Jean-Luc Cracowski
No abstract text is available yet for this article.
September 2018: Thérapie
https://www.readbyqxmd.com/read/29229217/non-cancer-drug-consumption-during-the-early-trajectory-of-lymphoma-survivorship
#16
Catherine Rioufol, Sébastien Lamy, Cécile Conte, Pauline Jeanneau, Giselle Compaci, Cyrille Delpierre, Maryse Lapeyre-Mestre, Guy Laurent, Fabien Despas
PURPOSE: This study explored the use of non-cancer drugs in lymphoma survivors during the early trajectory (0 to 2 years) of cancer survivorship and determined the factors that influenced this consumption. METHODS: Between January and March 2014, a cross-sectional survey was conducted to assess drug consumption in adult lymphoma survivors at the Toulouse University Hospital. This study was based on a questionnaire consisting of ten open questions related to medical prescription and/or self-medication occurring within the last 3 months...
September 2018: Thérapie
https://www.readbyqxmd.com/read/29224920/-pharmaceutical-cognitive-doping-in-students-a-chimeric-way-to-get-a-head
#17
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the pressing demands for memorization, top-level performance, and peer competition create an environment favorable for pharmaceutical cognitive doping behavior. We aimed to describe recent practices and the benefit / risk ratio of such behavior and to discuss the issues at stake. The prevalence of pharmaceutical cognitive doping among students has been reported from 1.3% to 33% across studies, with variations depending on country and definition of pharmaceutical cognitive doping. The therapeutic classes most frequently cited as being diverted for doping purposes are psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
September 2018: Thérapie
https://www.readbyqxmd.com/read/30197228/-illogical-association-nalmefene-and-opioids-analysis-in-the-french-pharmacovigilance-database
#18
Sylvie Favrelière, Claire Lafay-Chebassier, Bernard Fauconneau, Alexandre Quillet, Mélissa Yéléhé-Okouma, François Montastruc, Marie-Christine Pérault-Pochat
INTRODUCTION: Nalmefene, an opioid antagonist, causes withdrawal syndromes in patients exposed to an opioid agonist. Despite its contraindication, this illogical drug association persists, especially with opioid substitution drugs (ODS). We measured the benefits of the modification in the summary of product characteristics (SPC) in March 2015 and the package leaflet of Selincro® in September 2016 on this misuse. MATERIAL AND METHOD: We analyzed the observations regarding a use of nalmefene with an opioid between September 2014 and August 2017 in the French pharmacovigilance database and the laboratory...
August 3, 2018: Thérapie
https://www.readbyqxmd.com/read/30193805/-from-psychoactive-medicines-to-addictovigilance-in-french-public-health-code-1990-2017
#19
Marie Baumevieille, Joëlle Perri-Plandé, Ghada Miremont-Salamé, Amélie Daveluy, Françoise Haramburu
Addictovigilance in the French Public Health Code, in the section related to poisonous substances, refers to a monitoring system developed since 1990: control of psychoactive substances and products, with medicinal use or not, was completed by a specific system focused on evaluation and information on pharmacodependance in 1999. The French medicines agency (Agence du médicament) created in 1993 was involved in this monitoring system; pharmacodependance evaluation was added by law to the missions of the agencies that followed: the Agence française de sécurité sanitaire des produits de santé missions (AFSSAPS, 1998) and the Agence nationale de sécurité du médicament et des produits de santé (ANSM, 2011)...
August 3, 2018: Thérapie
https://www.readbyqxmd.com/read/30197230/decompensation-of-adrenal-insufficiency-associated-with-birch-juice-use-as-stated-by-the-manufacturer-information-leaflet-a-case-report
#20
LETTER
Cécile Fokoun, Vanessa Labeye, Elodie Puzenat, Marina Atzenhoffer, Alain Sigal, Bruno Charpiat
No abstract text is available yet for this article.
August 2, 2018: Thérapie
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