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Lab Animal

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https://www.readbyqxmd.com/read/28328903/response-to-protocol-review-scenario-fcr-and-defining-the-review-process
#1
Kimberly Jen, Jason Villano
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328902/stressed-out-providing-laboratory-animals-with-behavioral-control-to-reduce-the-physiological-effects-of-stress
#2
Brianna N Gaskill, Joseph P Garner
Laboratory animals experience a large amount of environmental stress. An animal's environment can include both physiological and social stressors that may require an animal to adapt to maintain allostatic balance. For example, thermal stress can lead to changes in behavior, reproduction and immune function, which has been detrimental to cancer modeling in mice. Chronic uncontrollable stress is widely acknowledged for its negative alterations to physiology. However, there is a lack in the understanding of how the laboratory environment affects animal physiology and behavior, particularly as it relates to characteristics of the human disease being modeled...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328901/policy-watch-putting-the-new-terms-on-usda-inspection-reports-into-perspective
#3
B Taylor Bennett, Matthew R Bailey
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328900/beasts-of-burden-large-animal-chimeras-using-human-pluripotent-stem-cells
#4
Dustin M Graham
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328899/openness-and-transparency-in-animal-research
#5
Wendy Jarrett
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328898/more-than-3rs-the-importance-of-scientific-validity-for-harm-benefit-analysis-of-animal-research
#6
Hanno W├╝rbel
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328897/a-gal4-uas-system-for-the-worm-community
#7
Dustin M Graham
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328896/microbiota-and-reproducibility-of-rodent-models
#8
REVIEW
Craig L Franklin, Aaron C Ericsson
The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and preclinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328895/side-effects-of-pain-and-analgesia-in-animal-experimentation
#9
REVIEW
Paulin Jirkof
This review highlights selected effects of untreated pain and of widely used analgesics such as opioids, non-steroid anti-inflammatory drugs and antipyretics, to illustrate the relevance of carefully planned, appropriate and controlled analgesia for greater reproducibility in animal experiments involving laboratory rodents.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328894/laboratory-environmental-factors-and-pain-behavior-the-relevance-of-unknown-unknowns-to-reproducibility-and-translation
#10
Jeffrey S Mogil
The poor record of basic-to-clinical translation in recent decades has led to speculation that preclinical research is "irreproducible", and this irreproducibility in turn has largely been attributed to deficiencies in reporting and statistical practices. There are, however, a number of other reasonable explanations of both poor translation and difficulties in one laboratory replicating the results of another. This article examines these explanations as they pertain to preclinical pain research. I submit that many instances of apparent irreproducibility are actually attributable to interactions between the phenomena and interventions under study and "latent" environmental factors affecting the rodent subjects...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328893/improving-quality-of-science-through-better-animal-welfare-the-nc3rs-strategy
#11
Mark J Prescott, Katie Lidster
Good animal welfare is linked to the quality of research data derived from laboratory animals, their validity as models of human disease, the number of animals required to reach statistical significance and the reproducibility of in vivo studies. Identifying new ways of understanding and improving animal welfare, and promoting these in the scientific community, is therefore a key part of the work of the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). Our strategy for animal welfare includes funding research to generate an evidence base to support refinements, office-led data sharing to challenge existing practices, events and networks to raise awareness of the evidence base, and the creation of online and other resources to support practical implementation of refinement opportunities...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328892/the-forces-behind-fin-regeneration
#12
Ellen P Neff
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328891/a-license-to-cure
#13
Cathleen Lutz
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328890/confidence-in-preclinical-research
#14
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328889/sanitized-corncob-bedding-destruction-of-murine-parvovirus
#15
Rigoberto Sanchez, David Johnson, Matthew C Terzi, Michelle Izuka, E Douglas Allen, Michael O'Donnoghue, Aubrey Mendonca, Kelly Yachera, Louis DeTolla
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328888/better-lab-animal-models-for-translational-neuroscience-research-and-cns-drug-development
#16
Darya A Meshalkina, Cai Song, Allan V Kalueff
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328887/public-perception-matters
#17
Tom Holder
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328886/response-to-protocol-review-scenario-a-word-from-olaw-and-the-usda
#18
Patricia Brown, Bernadette Juarez
No abstract text is available yet for this article.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328885/introducing-therioepistemology-the-study-of-how-knowledge-is-gained-from-animal-research
#19
REVIEW
Joseph P Garner, Brianna N Gaskill, Elin M Weber, Jamie Ahloy-Dallaire, Kathleen R Pritchett-Corning
This focus issue of Lab Animal coincides with a tipping point in biomedical research. For the first time, the scale of the reproducibility and translatability crisis is widely understood beyond the small cadre of researchers who have been studying it and the pharmaceutical and biotech companies who have been living it. Here we argue that an emerging literature, including the papers in this focus issue, has begun to congeal around a set of recurring themes, which themselves represent a paradigm shift. This paradigm shift can be characterized at the micro level as a shift from asking "what have we controlled for in this model?" to asking "what have we chosen to ignore in this model, and at what cost?" At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328884/aggression-in-group-housed-laboratory-mice-why-can-t-we-solve-the-problem
#20
Elin M Weber, Jamie Ahloy Dallaire, Brianna N Gaskill, Kathleen R Pritchett-Corning, Joseph P Garner
Group housing is highly important for social animals. However, it can also give rise to aggression, one of the most serious welfare concerns in laboratory mouse husbandry. Severe fighting can lead to pain, injury and even death. In addition, working with animals that are severely socially stressed, wounded or singly-housed as a result of aggression may compromise scientific validity. Some general recommendations on how to minimize aggression exist, but the problem persists. Thus far, studies attempting to find solutions have mainly focused on social dominance and territorial behavior, but many other aspects of routine housing and husbandry that might influence aggressive behavior have been overlooked...
March 22, 2017: Lab Animal
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