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Archives of Toxicology

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https://www.readbyqxmd.com/read/29043426/roles-of-cytosolic-phospholipase-a2%C3%AE-in-reproductive-and-systemic-toxicities-in-2-3-7-8-tetrachlorodibenzo-p-dioxin-exposed-mice
#1
Nozomi Fujisawa, Wataru Yoshioka, Hiroyuki Yanagisawa, Chiharu Tohyama
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a variety of toxicities upon binding of TCDD to aryl hydrocarbon receptor. Although this binding upregulates the synthesis of prostaglandins and their related lipid mediators via cytosolic phospholipase A2α (cPLA2α), toxicological significance of this signaling pathway remains elusive. Herein, we investigated the roles of cPLA2α in TCDD toxicities using cPLA2α-null mice. In a first set of experiments, pregnant mice were orally administered TCDD at a dose of 40 μg/kg on gestation day (GD) 12...
October 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29043425/arylamine-n-acetyltransferase-1-in-situ-n-acetylation-on-cd3-peripheral-blood-mononuclear-cells-correlate-with-natb-mrna-and-nat1-haplotype
#2
Raúl A Salazar-González, Eneida Turiján-Espinoza, David W Hein, Perla C Niño-Moreno, Silvia Romano-Moreno, Rosa C Milán-Segovia, Diana P Portales-Pérez
Human arylamine N-acetyltransferase 1 (NAT1) is responsible for the activation and elimination of xenobiotic compounds and carcinogens. Genetic polymorphisms in NAT1 modify both drug efficacy and toxicity. Previous studies have suggested a role for NAT1 in the development of several diseases. The aim of the present study was to evaluate NAT1 protein expression and in situ N-acetylation capacity in peripheral blood mononuclear cells (PBMC), as well as their possible associations with the expression of NAT1 transcript and NAT1 genotype...
October 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29038840/gabaa-receptor-subtype-selectivity-of-the-proconvulsant-rodenticide-tets
#3
Brandon Pressly, Hai M Nguyen, Heike Wulff
The rodenticide tetramethylenedisulfotetramine (TETS) is a potent convulsant (lethal dose in humans 7-10 mg) that is listed as a possible threat agent by the United States Department of Homeland Security. TETS has previously been studied in vivo for toxicity and in vitro in binding assays, with the latter demonstrating it to be a non-competitive antagonist on GABAA receptors. To determine whether TETS exhibits subtype selectivity for a particular GABAA receptor combination, we used whole-cell patch-clamp to determine the potency of TETS on the major synaptic and extrasynaptic GABAA receptors associated with convulsant activity...
October 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29038839/hepatotoxic-combination-effects-of-three-azole-fungicides-in-a-broad-dose-range
#4
T Heise, F Schmidt, C Knebel, S Rieke, W Haider, I Geburek, L Niemann, P Marx-Stoelting
Single active substances of pesticides are thoroughly examined for their toxicity before approval. In this context, the liver is frequently found to be the main target organ. Since consumers are generally exposed to multiple residues of different active substances via the diet, it is important to analyse combinations of active substances for potential mixture effects. For the (tri-)azoles, a group of agricultural fungicides and antifungal drugs, combination effects on the liver are likely because of a similar mode of action...
October 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29038838/respiratory-sensitization-toxicological-point-of-view-on-the-available-assays
#5
Aline Chary, Jennifer Hennen, Sebastian G Klein, Tommaso Serchi, Arno C Gutleb, Brunhilde Blömeke
Respiratory sensitization as a consequence of exposure to chemical products has increased over the last decades, leading to an increase of morbidity. The increased use of synthetic compounds resulted in an exponential growth of substances to which we are potentially exposed on a daily basis. Some of them are known to induce respiratory sensitization, meaning that they can trigger the development of allergies. In the past, animal studies provided useful results for the understanding of mechanisms involved in the development of respiratory allergies...
October 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29030652/evidence-for-a-complex-formation-between-cyp2j5-and-meh-in-living-cells-by-fret-analysis-of-membrane-protein-interaction-in-the-endoplasmic-reticulum-fampir
#6
Anette Carolina Orjuela Leon, Anne Marwosky, Michael Arand
The potential complex formation between microsomal epoxide hydrolase (mEH) and cytochrome P450-dependent monooxygenase (CYP) has been a subject of research for many decades. Such an association would enable efficient substrate channeling between CYP and mEH and as such represent an attractive strategy to prevent deleterious accumulation of harmful metabolic by-products such as CYP-generated epoxide intermediates. However, such complex formation is experimentally difficult to prove, because CYP and mEH are membrane-bound proteins that are prone to unspecific aggregation after solubilization...
October 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29030651/third-symposium-on-environmental-toxicology-in-north-rhine-westphalia-germany-interdisciplinary-research-activities-in-toxicology-statistics-hygiene-and-medicine-meeting-report-on-a-symposium-held-in-dortmund-may-7-8-2015
#7
Klaus Golka, Katja Ickstadt, Silvia Selinski, Jan G Hengstler, Michael Wilhelm
No abstract text is available yet for this article.
October 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29018892/novel-treatment-opportunities-for-sulfur-mustard-related-cancers-genetic-and-epigenetic-perspectives
#8
REVIEW
Soheila Rahmani, Mohammad Abdollahi
Sulfur mustard (SM), also known as mustard gas, is a chemical weapon which by now has been used in many wars. The most concerning SM toxic effect is probable carcinogenicity. In this study, the genetic and epigenetic mechanisms of SM carcinogenicity, by focusing on treatment of SM-associated malignancies, particularly gene therapeutics, cancer vaccines, and epigenetic medications, have been criticized. The required data were collected through an organized search on valid scientific databases. For SM carcinogenicity due to acute or chronic exposure, the entire original and review articles were evaluated...
October 10, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28993953/intestinal-toxicity-of-deoxynivalenol-is-limited-by-lactobacillus-rhamnosus-rc007-in-pig-jejunum-explants
#9
Gisela Romina García, Delphine Payros, Philippe Pinton, Cecilia Ana Dogi, Joëlle Laffitte, Manon Neves, María Laura González Pereyra, Lilia Renée Cavaglieri, Isabelle P Oswald
Probiotics have been explored to stimulate gut health in weaned pigs, when they started to consume solid diet where mycotoxins could be present. The aim of this study was to evaluate the effect of Lactobacillus rhamnosus RC007 on the intestinal toxicity of deoxynivalenol (DON) in an ex vivo model. Jejunal explants, obtained from 5-week-old crossbred castrated male piglets, were kept as control, exposed for 3 h to 10 μM DON, incubated for 4 h with 10(9) CFU/mL L. rhamnosus, or pre-incubated 1 h with 10(9) L...
October 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28993908/ros-generation-and-jnk-activation-contribute-to-4-methoxy-tempo-induced-cytotoxicity-autophagy-and-dna-damage-in-hepg2-cells
#10
Zhuhong Zhang, Zhen Ren, Si Chen, Xiaoqing Guo, Fang Liu, Lei Guo, Nan Mei
4-Methoxy-TEMPO, a derivative of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), is a stable nitroxide radical and is generally used in organic and pharmaceutical syntheses for the oxidation of alcohols. Previously, we reported the involvement of reactive oxygen species (ROS) and c-Jun N-terminal kinases (JNK) in TEMPO-induced apoptosis in mouse L5178Y cells. In this study, we investigated 4-methoxy-TEMPO induced toxicity in human HepG2 hepatoma cells and its underlying mechanisms. Treatments with 4-methoxy-TEMPO (0...
October 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28993852/the-effects-of-the-obesogen-tributyltin-on-the-metabolism-of-sertoli-cells-cultured-ex-vivo
#11
Ana M Cardoso, Marco G Alves, Ana C Sousa, Ivana Jarak, Rui A Carvalho, Pedro F Oliveira, José E Cavaco, Luís Rato
Human exposure to environmental contaminants is widespread. Some of these contaminants have the ability to interfere with adipogenesis, being thus considered as obesogens. Recently, obesogens have been singled out as a cause of male infertility. Sertoli cells (SCs) are essential for male fertility and their metabolic performance, especially glucose metabolism, is under a tight endocrine control, being essential for the success of spermatogenesis. Herein, we studied the impact of the model obesogen tributyltin in the metabolic profile of SCs...
October 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28980048/protective-effects-of-the-resveratrol-analog-piceid-in-dopaminergic-sh-sy5y-cells
#12
Sneha Potdar, Mayur S Parmar, Sidhartha D Ray, Jane E Cavanaugh
Age-related motor deficits, such as loss of balance and coordination, are caused, in part, by loss of dopaminergic neurons. Oxidative stress is known to play a role in this neuronal loss. Resveratrol, a natural antioxidant with anticancer and anti-inflammatory potential, has been shown to protect dopaminergic-like cells (SH-SY5Y) against oxidative stress. However, the low bioavailability of resveratrol makes it worthwhile to explore newer compounds with similar properties. Piceid (RV8), an analog of resveratrol, has greater bioavailability than resveratrol, and our studies found that piceid (10, 20, 30 µM) protects SH-SY5Y cells against oxidative stress...
October 4, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28980015/erratum-to-modelling-foetal-exposure-to-maternal-smoking-using-hepatoblasts-from-pluripotent-stem-cells
#13
Baltasar Lucendo-Villarin, Panagiotis Filis, Madeleine J Swortwood, Marilyn A Huestis, Jose Meseguer-Ripolles, Kate Cameron, John P Iredale, Peter J O'Shaughnessy, Paul A Fowler, David C Hay
During manuscript proofing, the following sentence was not deleted in the section "Results" at the end of the paragraph: "Both male and female hepatocytes responded in a similar fashion to cotinine, whereas male hepatocyte function was more sensitive to chrysene, fluorene and naphthalene than female hepatocytes".
October 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28975372/t-buooh-induces-ferroptosis-in-human-and-murine-cell-lines
#14
Christine Wenz, Dagmar Faust, Berenike Linz, Christian Turmann, Teodora Nikolova, John Bertin, Peter Gough, Peter Wipf, Anna Sophia Schröder, Stefan Krautwald, Cornelia Dietrich
Reactive oxygen species (ROS)-induced apoptosis has been extensively studied. Increasing evidence suggests that ROS, for instance, induced by hydrogen peroxide (H2O2), might also trigger regulated necrotic cell death pathways. Almost nothing is known about the cell death pathways triggered by tertiary-butyl hydroperoxide (t-BuOOH), a widely used inducer of oxidative stress. The lipid peroxidation products induced by t-BuOOH are involved in the pathophysiology of many diseases, such as cancer, cardiovascular diseases, or diabetes...
October 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28975368/obesogenic-endocrine-disruptors-and-obesity-myths-and-truths
#15
REVIEW
Giovanna Muscogiuri, Luigi Barrea, Daniela Laudisio, Silvia Savastano, Annamaria Colao
Obesogenic endocrine disruptors, also known as obesogens, are chemicals potentially involved in weight gain by altering lipid homeostasis and promoting adipogenesis and lipid accumulation. They included compounds to which human population is exposed over daily life such as pesticides/herbicides, industrial and household products, plastics, detergents and personal care products. The window of life during which the exposure happens could lead to different effects. A critical window is during utero and/or neonatal period in which the obesogens could cause subtle changes in gene expression and tissue organization or blunt other levels of biological organization leading to increased susceptibility to diseases in the adulthood...
October 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28975360/beyond-detoxification-a-role-for-mouse-meh-in-the-hepatic-metabolism-of-endogenous-lipids
#16
Anne Marowsky, Imke Meyer, Kira Erismann-Ebner, Giovanni Pellegrini, Nandkishor Mule, Michael Arand
Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadecenoic acids (EpOMEs), which are formed by CYP epoxygenases from arachidonic acid (AA) and linoleic acid, respectively, and then are hydrolyzed to their respective diols, the so-called DHETs and DiHOMEs...
October 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28965233/prediction-of-liver-toxicity-and-mode-of-action-using-metabolomics-in-vitro-in-hepg2-cells
#17
Tzutzuy Ramirez, Alexander Strigun, Andreas Verlohner, Hans-Albrecht Huener, Erik Peter, Michael Herold, Natalie Bordag, Werner Mellert, Tilmann Walk, Michael Spitzer, Xiaoqi Jiang, Saskia Sperber, Thomas Hofmann, Thomas Hartung, Hennicke Kamp, Ben van Ravenzwaay
Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal welfare, in vitro techniques facilitate exploring and understanding the molecular mechanisms underlying toxicity. New 'omics technologies can provide comprehensive information on the toxicological mode of action of compounds, as well as quantitative information about the multi-parametric metabolic response of cellular systems in normal and patho-physiological conditions...
September 30, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28956099/arsenite-and-methylarsonite-inhibit-mitochondrial-metabolism-and-glucose-stimulated-insulin-secretion-in-ins-1-832-13-%C3%AE-cells
#18
E N Dover, R Beck, M C Huang, C Douillet, Z Wang, E L Klett, Miroslav Stýblo
Growing evidence suggests that exposure to environmental contaminants contributes to the current diabetes epidemic. Inorganic arsenic (iAs), a drinking water and food contaminant, is one of the most widespread environmental diabetogens according to epidemiological studies. Several schemes have been proposed to explain the diabetogenic effects of iAs exposure; however, the exact mechanism remains unknown. We have shown that in vitro exposure to low concentrations of arsenite (iAs(III)) or its trivalent methylated metabolites, methylarsonite (MAs(III)) and dimethylarsinite (DMAs(III)), inhibits glucose-stimulated insulin secretion (GSIS) from isolated pancreatic islets, with little effect on insulin transcription or total insulin content...
September 27, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28956089/toxicokinetic-of-tris-2-butoxyethyl-phosphate-tboep-in-humans-following-single-oral-administration
#19
Wolfgang Völkel, Veronika Fuchs, Mandy Wöckner, Hermann Fromme
Tris(2-butoxyethyl) phosphate (TBOEP; 20 µg/kg b.w.) was orally administered to three female and three male volunteers. In urine samples collected for 39 h three metabolites of TBOEP were quantitated. bis(2-butoxyethyl) phosphate (BBOEP), tris(2-(3-hydroxy)butoxyethyl) phosphate (OH-TBOEP), bis(2-butoxyethyl)-(2-hydroxyethyl) phosphate (BBOEHEP) were observed in all urine samples within the first 7 h with highest concentration for BBOEHEP. C max of OH-TBOEP was in the range of 2-4 h and t 1/2 was between 1...
September 27, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28952001/exposures-to-arsenite-and-methylarsonite-produce-insulin-resistance-and-impair-insulin-dependent-glycogen-metabolism-in-hepatocytes
#20
Chongben Zhang, Emily M J Fennel, Christelle Douillet, Miroslav Stýblo
Environmental exposure to inorganic arsenic (iAs) has been shown to disturb glucose homeostasis, leading to diabetes. Previous laboratory studies have suggested several mechanisms that may underlie the diabetogenic effects of iAs exposure, including (i) inhibition of insulin signaling (leading to insulin resistance) in glucose metabolizing peripheral tissues, (ii) inhibition of insulin secretion by pancreatic β cells, and (iii) dysregulation of the methylation or expression of genes involved in maintenance of glucose or insulin metabolism and function...
September 26, 2017: Archives of Toxicology
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