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Archives of Toxicology

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https://www.readbyqxmd.com/read/28725974/carbofuran-causes-neuronal-vulnerability-to-glutamate-by-decreasing-glua2-protein-levels-in-rat-primary-cortical-neurons
#1
Kanae Umeda, Masatsugu Miyara, Keishi Ishida, Seigo Sanoh, Shigeru Ohta, Yaichiro Kotake
Glutamate receptor 2 (GluA2/GluR2) is one of the four subunits of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR); an increase in GluA2-lacking AMPARs contributes to neuronal vulnerability to excitotoxicity because of the receptor's high Ca(2+) permeability. Carbofuran is a carbamate pesticide used in agricultural areas to increase crop productivity. Due to its broad-spectrum action, carbofuran has also been used as an insecticide, nematicide, and acaricide. In this study, we investigated the effect of carbofuran on GluA2 protein expression...
July 19, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28721440/selectivity-of-plasma-membrane-calcium-atpase-pmca-mediated-extrusion-of-toxic-divalent-cations-in-vitro-and-in-cultured-cells
#2
Mariela S Ferreira-Gomes, Irene C Mangialavori, Mallku Q Ontiveros, Debora E Rinaldi, Jorge Martiarena, Sandra V Verstraeten, Juan Pablo F C Rossi
In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca(2+) homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca(2+)-binding proteins and/or Ca(2+) pumps. The plasma membrane calcium pump (PMCA) maintains Ca(2+) homeostasis in eukaryotic cells by mediating the efflux of this cation in a process coupled to ATP hydrolysis. The aim of this work was to investigate both in vitro and in cultured cells if other divalent cations (Sr(2+), Ba(2+), Co(2+), Cd(2+), Pb(2+) or Be(2+)) could be transported by PMCA...
July 18, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28717830/a-review-of-drug-induced-liver-injury-databases
#3
REVIEW
Guangwen Luo, Yiting Shen, Lizhu Yang, Aiping Lu, Zheng Xiang
Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB...
July 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28710503/rac1-mediated-cardiac-damage-causes-diastolic-dysfunction-in-a-mouse-model-of-subacute-doxorubicin-induced-cardiotoxicity
#4
Jan Ohlig, Christian Henninger, Simone Zander, Marc Merx, Malte Kelm, Gerhard Fritz
The anticancer efficacy of anthracyclines is limited by congestive heart failure. Clinically established markers of early onset of cardiotoxicity following anthracycline treatment and preventive measures are missing. Although statins are reported to alleviate anthracycline-induced cardiotoxicity in vivo, the molecular mechanisms involved remain elusive. In vitro data point to Rac1 as major target of the cytoprotective statin effects. Here we investigated whether specific inhibition of Rac1 by NSC23766 is as effective as lovastatin in preventing subacute cardiotoxicity following doxorubicin treatment...
July 14, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28707023/oxidative-inactivation-of-the-endogenous-antioxidant-protein-dj-1-by-the-food-contaminants-3-mcpd-and-2-mcpd
#5
Thorsten Buhrke, Linn Voss, Anja Briese, Heike Stephanowitz, Eberhard Krause, Albert Braeuning, Alfonso Lampen
3-Chloro-1,2-propanediol (3-MCPD) and 2-chloro-1,3-propanediol (2-MCPD) are heat-induced food contaminants being present either as free substances or as fatty acid esters in numerous foods. 3-MCPD was classified to be possibly carcinogenic to humans (category 2B) with kidney and testis being the primary target organs according to animal studies. A previous 28-day oral feeding study with rats revealed that the endogenous antioxidant protein DJ-1 was strongly deregulated at the protein level in kidney, liver, and testis of the experimental animals that had been treated either with 3-MCPD, 2-MCPD or their dipalmitate esters...
July 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28702692/reply-to-the-commentary-by-lotti-m-and-moretto-a-organophosphate-neurotoxicity-to-the-voluntary-motor-system-on-the-trail-of-environment-caused-amyotrophic-lateral-sclerosis-the-known-the-misknown-and-the-unknown
#6
LETTER
Samantha J Merwin, Teresa Obis, Yanelli Nunez, Diane B Re
No abstract text is available yet for this article.
July 12, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28702691/toxic-effects-and-biodistribution-of-ultrasmall-gold-nanoparticles
#7
REVIEW
Günter Schmid, Wolfgang G Kreyling, Ulrich Simon
Gold nanoparticles (AuNPs) have been extensively explored in biomedical applications, for example as drug carriers, contrast agents, or therapeutics. However, AuNP can exhibit cytotoxic profile, when the size is below 2 nm (ultrasmall AuNP; usAuNP) and when the stabilizing ligands allow for access to the gold surface either for the direct interaction with biomolecules or for catalytic activity of the unshielded gold surface. Furthermore, usAuNP exhibits significantly different biodistribution and enhanced circulation times compared to larger AuNP...
July 12, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28695231/erratum-to-role-of-the-aryl-hydrocarbon-receptor-in-carcinogenesis-and-potential-as-an-anti-cancer-drug-target
#8
Siva Kumar Kolluri, Un-Ho Jin, Stephen Safe
No abstract text is available yet for this article.
July 11, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28681081/genome-wide-mapping-and-analysis-of-aryl-hydrocarbon-receptor-ahr-and-aryl-hydrocarbon-receptor-repressor-ahrr-binding-sites-in-human-breast-cancer-cells
#9
Sunny Y Yang, Shaimaa Ahmed, Somisetty V Satheesh, Jason Matthews
The aryl hydrocarbon receptor (AHR) mediates the toxic actions of environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), and also plays roles in vascular development, the immune response, and cell cycle regulation. The AHR repressor (AHRR) is an AHR-regulated gene and a negative regulator of AHR; however, the mechanisms of AHRR-dependent repression of AHR are unclear. In this study, we compared the genome-wide binding profiles of AHR and AHRR in MCF-7 human breast cancer cells treated for 24 h with TCDD using chromatin immunoprecipitation followed by next-generation sequencing (ChIP-Seq)...
July 5, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28676953/regulation-of-sirt1-ampk-axis-is-critically-involved-in-gallotannin-induced-senescence-and-impaired-autophagy-leading-to-cell-death-in-hepatocellular-carcinoma-cells
#10
Hee Young Kwon, Ju-Ha Kim, Bonglee Kim, Sanjay K Srivastava, Sung-Hoon Kim
Hepatocellular carcinoma (HCC) is one of the most fatal malignancies with high mortality worldwide. Here the underlying antitumor mechanism of gallotannin was elucidated in HCC cells. Gallotannin suppressed viability and colony formation, increased subG1 portion and also induced senescence via upregulation of p21, G0/G1 arrest and higher SA-β-gal activity in HepG2 and SK-Hep1 cells. However, pan-caspase inhibitor Z-VAD-FMK reversed the ability of gallotannin to activate caspase 3 at 48 h after treatment in two HCC cells...
July 4, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28674726/lung-damage-analyzed-by-machine-vision-on-tissue-sections-of-mice
#11
Chen Tao, Yingmei Zhang
The inhalation of environmental toxicants can induce lung damage. Many methods are currently available to analyze lung tissue damage and are based on empirical visual judgment; however, the accuracy of the assessments are influenced by individual differences among pathologists. Here, we establish new methods of analysis for lung tissue sections based on machine vision and verify this new automatic high-flux method with the model of mice inhaling aqueous aerosol with different concentrations of CdCl2 (0, 1, 3, 5 mM 2 h/day) for 7 days through analyses of pulmonary porosity, mucus, pneumonia and co-localized staining...
July 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28664260/highlight-report-co-cultures-of-hepatocytes-and-macrophages-for-hepatotoxicity-testing
#12
EDITORIAL
Abdel-Latif Seddek, Aya A Abbas
No abstract text is available yet for this article.
June 29, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28660287/adverse-outcome-pathways-a-concise-introduction-for-toxicologists
#13
LETTER
Mathieu Vinken, Dries Knapen, Lucia Vergauwen, Jan G Hengstler, Michelle Angrish, Maurice Whelan
Adverse outcome pathways (AOPs) are designed to provide a clear-cut mechanistic representation of critical toxicological effects that propagate over different layers of biological organization from the initial interaction of a chemical with a molecular target to an adverse outcome at the individual or population level. Adverse outcome pathways are currently gaining momentum, especially in view of their many potential applications as pragmatic tools in the fields of human toxicology, ecotoxicology, and risk assessment...
June 28, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28643002/genotoxicity-testing-of-different-surface-functionalized-sio2-zro2-and-silver-nanomaterials-in-3d-human-bronchial-models
#14
Andrea Haase, Nils Dommershausen, Markus Schulz, Robert Landsiedel, Philipp Reichardt, Benjamin-Christoph Krause, Jutta Tentschert, Andreas Luch
Inhalation is considered a critical uptake route for NMs, demanding for sound toxicity testing using relevant test systems. This study investigates cytotoxicity and genotoxicity in EpiAirway™ 3D human bronchial models using 16 well-characterized NMs, including surface-functionalized 15 nm SiO2 (4 variants), 10 nm ZrO2 (4), and nanosilver (3), ZnO NM-110, TiO2 NM-105, BaSO4 NM-220, and two AlOOH NMs. Cytotoxicity was assessed by LDH and ATP assays and genotoxicity by the alkaline comet assay. For 9 NMs, uptake was investigated using inductively coupled plasma-mass spectrometry (ICP-MS)...
June 22, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28638985/glucuronidation-of-deoxynivalenol-don-by-different-animal-species-identification-of-iso-don-glucuronides-and-iso-deepoxy-don-glucuronides-as-novel-don-metabolites-in-pigs-rats-mice-and-cows
#15
Heidi E Schwartz-Zimmermann, Christian Hametner, Veronika Nagl, Iris Fiby, Lukas Macheiner, Janine Winkler, Sven Dänicke, Erica Clark, James J Pestka, Franz Berthiller
The Fusarium mycotoxin deoxynivalenol (DON) is a frequent contaminant of cereal-based food and feed. Mammals metabolize DON by conjugation to glucuronic acid (GlcAc), the extent and regioselectivity of which is species-dependent. So far, only DON-3-glucuronide (DON-3-GlcAc) and DON-15-GlcAc have been unequivocally identified as mammalian DON glucuronides, and DON-7-GlcAc has been proposed as further DON metabolite. In the present work, qualitative HPLC-MS/MS analysis of urine samples of animals treated with DON (rats: 2 mg/kg bw, single bolus, gavage; mice: 1 mg/kg bw, single i...
June 21, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28634823/a-nationwide-study-of-the-incidence-rate-of-herb-induced-liver-injury-in-korea
#16
Jung-Hyo Cho, Dal-Seok Oh, Sang-Hoon Hong, Heung Ko, Nam-Hun Lee, Sang-Eun Park, Chang-Woo Han, Seung-Mo Kim, Young-Chul Kim, Kang-San Kim, Chang-Won Choi, Seon-My Shin, Ki-Tae Kim, Hong-Sik Choi, Jang-Hoon Lee, Jun-Young Kim, Ji-Young Kang, Dong-Soo Lee, Yo-Chan Ahn, Chang-Gue Son
Discrepant incidence has been reported regarding the incidence of herb-induced liver injury (HILI). To address the growing worldwide concern of HILI, we evaluated the risk of HILI in a nationwide prospective study. Between April 2013 and January 2016, 1001 inpatients (360 males and 641 females) from 10 tertiary hospitals throughout South Korea were treated with herbal drugs and had their liver enzymes periodically measured. A total of six patients met the criteria for HILI with RUCAM scores ranging from 4 to 7...
June 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28623480/the-current-debate-on-cost-burden-by-human-exposure-to-endocrine-disrupting-chemicals
#17
EDITORIAL
Hermann M Bolt
No abstract text is available yet for this article.
June 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28620673/first-evidence-of-pyrrolizidine-alkaloid-n-oxide-induced-hepatic-sinusoidal-obstruction-syndrome-in-humans
#18
Mengbi Yang, Jianqing Ruan, Hong Gao, Na Li, Jiang Ma, Junyi Xue, Yang Ye, Peter Pi-Cheng Fu, Jiyao Wang, Ge Lin
Pyrrolizidine alkaloids (PAs) are among the most potent phytotoxins widely distributed in plant species around the world. PA is one of the major causes responsible for the development of hepatic sinusoidal obstruction syndrome (HSOS) and exerts hepatotoxicity via metabolic activation to form the reactive metabolites, which bind with cellular proteins to generate pyrrole-protein adducts, leading to hepatotoxicity. PA N-oxides coexist with their corresponding PAs in plants with varied quantities, sometimes even higher than that of PAs, but the toxicity of PA N-oxides remains unclear...
June 15, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28620672/re-tarazona-et-al-2017-glyphosate-toxicity-and-carcinogenicity-a-review-of-the-scientific-basis-of-the-european-union-assessment-and-its-differences-with-iarc-doi-10-1007-s00204-017-1962-5
#19
LETTER
https://www.readbyqxmd.com/read/28616630/experimental-and-computational-insights-on-the-recognition-mechanism-between-the-estrogen-receptor-%C3%AE-with-bisphenol-compounds
#20
Huiming Cao, Fengbang Wang, Yong Liang, Hailin Wang, Aiqian Zhang, Maoyong Song
Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, we systematically investigated the estrogenic potency of 14 selected BP analogs with typical structures using experimental and computational methods. Most of the tested BP analogs exhibited weak estrogenic activities in both cell proliferation and MVLN assays with the exception of TBBPA, TCBPA and TBBPS...
June 14, 2017: Archives of Toxicology
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