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Archives of Toxicology

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https://www.readbyqxmd.com/read/30539213/re-gi-et-al-2018-in-vivo-positive-mutagenicity-of-1-4-dioxane-and-quantitative-analysis-of-its-mutagenicity-and-carcinogenicity-in-rats-archives-of-toxicology-92-3207-3221
#1
LETTER
Paul A White, Andreas Zeller, Stefan Pfuhler, George E Johnson
No abstract text is available yet for this article.
December 11, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30539212/compound-selection-and-annotation-to-validate-the-predictivity-of-in-vitro-toxicity-assays-for-use-in-drug-discovery-in-response-to-commentary-by-dr-zink-zink-d-arch-toxicol-2018
#2
LETTER
Anna-Karin Sjögren, Jorrit J Hornberg
No abstract text is available yet for this article.
December 11, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30535712/the-hemoglobin-adduct-n-2-3-dihydroxypropyl-valine-as-biomarker-of-dietary-exposure-to-glycidyl-esters-a-controlled-exposure-study-in-humans
#3
Klaus Abraham, Jan Hielscher, Tobias Kaufholz, Hans Mielke, Alfonso Lampen, Bernhard Monien
Fatty acid esters of glycidol (glycidyl esters) are heat-induced food contaminants predominantly formed during industrial deodorization of vegetable oils and fats. After consumption, the esters are digested in the gastrointestinal tract, leading to a systemic exposure to the reactive epoxide glycidol. The compound is carcinogenic, genotoxic and teratogenic in rodents, and rated as probably carcinogenic to humans (IARC group 2A). Assessment of exposure from occurrence and consumption data is difficult, as lots of different foods containing refined oils and fats may contribute to human exposure...
December 10, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30535711/the-role-of-roughage-provision-on-the-absorption-and-disposition-of-the-mycotoxin-deoxynivalenol-and-its-acetylated-derivatives-in-calves-from-field-observations-to-toxicokinetics
#4
Bonnie Valgaeren, Léonard Théron, Siska Croubels, Mathias Devreese, Siegrid De Baere, Els Van Pamel, Els Daeseleire, Marthe De Boevre, Sarah De Saeger, Arnau Vidal, José Diana Di Mavungu, Philipp Fruhmann, Gerhard Adam, Alfons Callebaut, Calixte Bayrou, Vincent Frisée, Anne-Sophie Rao, Emilie Knapp, Arnaud Sartelet, Bart Pardon, Piet Deprez, Gunther Antonissen
A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13 mg/kg feed) induced severe liver failure in 2- to 3-month-old beef calves. Symptoms disappeared by replacing the highly contaminated corn and by stimulating ruminal development via roughage administration. A multi-mycotoxin contamination was demonstrated in feed samples collected at 15 different veal farms in Belgium. DON was most prevalent, contaminating 80% of the roughage samples (mixed straw and maize silage; average concentration in positives: 637 ± 621 µg/kg, max...
December 10, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30511338/pgc-1%C3%AE-modulates-statin-associated-myotoxicity-in-mice
#5
François Singh, Joffrey Zoll, Urs Duthaler, Anne-Laure Charles, Miljenko V Panajatovic, Gilles Laverny, Thomas G McWilliams, Daniel Metzger, Bernard Geny, Stephan Krähenbühl, Jamal Bouitbir
Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. Statins are generally well tolerated, but can be associated with potentially life-threatening myopathy of unknown mechanism. We have shown previously that statins impair PGC-1β expression in human and rat skeletal muscle, suggesting that PGC-1β may play a role in statin-induced myopathy. PGC-1β is a transcriptional co-regulator controlling the expression of important genes in mitochondrial biogenesis, antioxidative capacity and energy metabolism...
December 3, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30499019/medicines-associated-with-folate-homocysteine-methionine-pathway-disruption
#6
REVIEW
M Vidmar, J Grželj, I Mlinarič-Raščan, K Geršak, M Sollner Dolenc
Folate is vital for cell development and growth. It is involved in one-carbon transfer reactions essential for the synthesis of purines and pyrimidines. It also acts in conjunction with cobalamin (vitamin B12 ) as a fundamental cofactor in the remethylation cycle that converts homocysteine to methionine. A deficiency in folate or vitamin B12 can lead to elevated homocysteine level, which has been identified as an independent risk factor in several health-related conditions. Adequate folate levels are essential in women of childbearing age and in pregnant women, and folate deficiency is associated with several congenital malformations...
November 29, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30499018/targeted-deletion-of-the-aryl-hydrocarbon-receptor-in-dendritic-cells-prevents-thymic-atrophy-in-response-to-dioxin
#7
Celine A Beamer, Joanna M Kreitinger, Shelby L Cole, David M Shepherd
In nearly every species examined, administration of the persistent environmental pollutant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin, TCDD) causes profound immune suppression and thymic atrophy in an aryl hydrocarbon receptor (AhR) dependent manner. Moreover, TCDD alters the development and differentiation of thymocytes, resulting in decreases in the relative proportion and absolute number of double positive (DP, CD4+ CD8+ ) thymocytes, as well as a relative enrichment in the relative proportion and absolute number of double negative (DN, CD4- CD8- ) and single-positive (SP) CD4+ CD8- and CD4- CD8+ thymocytes...
November 29, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30483840/exploring-sex-differences-in-human-health-risk-assessment-for-pfna-and-pfda-using-a-pbpk-model
#8
Sook-Jin Kim, Eun-Jeong Choi, Go-Wun Choi, Yong-Bok Lee, Hea-Young Cho
Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl and polyfluoroalkyl substances (PFASs), have been widely used in industrial applications as a surface protectant. PFASs have been detected in wildlife and in humans around the globe. The purposes of this study are to develop and validate a physiologically based pharmacokinetic (PBPK) model for detecting PFNA and PFDA in male and female rats, and to apply the model to a human health risk assessment regarding the sex difference...
November 27, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30478605/highlight-report-stem-cell-based-developmental-toxicity-tests
#9
EDITORIAL
Florian Seidel
No abstract text is available yet for this article.
November 26, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30470843/uptake-of-microplastics-and-related-health-effects-a-critical-discussion-of-deng-et-al-scientific-reports-7-46687-2017
#10
EDITORIAL
Albert Braeuning
No abstract text is available yet for this article.
November 23, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30467584/highlight-report-new-applications-of-chimeric-mice-with-humanized-livers
#11
EDITORIAL
Wiebke Albrecht
No abstract text is available yet for this article.
November 23, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30467583/in-vitro-proteomic-analysis-of-methapyrilene-toxicity-in-rat-hepatocytes-reveals-effects-on-intermediary-metabolism
#12
Albert Braeuning, Axel Oberemm, Tanja Heise, Ursula Gundert-Remy, Jan G Hengstler, Alfonso Lampen
The antihistaminic drug methapyrilene was withdrawn from the market in 1979 because of hepatocarcinogenicity in rats. Since then, the drug has been used as a model hepatotoxin especially for transcriptomic analyses using material from in vivo studies. Much less transcriptomics data are available from in vitro studies, and no studies have investigated proteomic effects of methapyrilene in vitro. Thus, the present study was aimed to characterize the proteomic response of primary rat hepatocytes to methapyrilene, to broaden our knowledge on the molecular mechanisms of methapyrilene toxicity, and to compare the results of collagen sandwich-cultured hepatocytes to in vivo data...
November 22, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30467582/the-dangers-of-preemptive-obedience-to-political-pressure-and-media-campaigns-in-science
#13
LETTER
Colin Berry
No abstract text is available yet for this article.
November 22, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30465056/highlight-report-humanized-mice-reveal-interspecies-differences-in-triclosan-hepatotoxicity
#14
EDITORIAL
Reham Hassan, Ahmed Ghallab
No abstract text is available yet for this article.
November 21, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30460423/3d-visualization-of-the-biliary-tree-by-x-ray-phase-contrast-computed-tomography
#15
EDITORIAL
Amruta Damle-Vartak
No abstract text is available yet for this article.
November 20, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30460422/micrornas-in-the-diagnosis-and-prevention-of-drug-induced-cardiotoxicity
#16
REVIEW
Mikuláš Skála, Barbora Hanousková, Lenka Skálová, Petra Matoušková
Drug-induced cardiotoxicity is a serious problem associated with the administration of many drugs. MicroRNAs (miRNAs) have been reported to be affected by drugs and other xenobiotics, and the potential of miRNAs as biomarkers and diagnostic tools has been considered. In recent years, an association of certain miRNAs with the cardiotoxicity of some drugs, namely anthracyclines, bevacizumab, cyclosporine A and isoprenaline, has already been found. This review article summarizes available information about the changes in miRNA levels induced by cardiotoxic drugs...
November 20, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30456486/a-systematic-analysis-of-nrf2-pathway-activation-dynamics-during-repeated-xenobiotic-exposure
#17
Luc J M Bischoff, Isoude A Kuijper, Johannes P Schimming, Liesanne Wolters, Bas Ter Braak, Jan P Langenberg, Daan Noort, Joost B Beltman, Bob van de Water
Oxidative stress leads to the activation of the Nuclear factor-erythroid-2-related factor 2 (Nrf2) pathway. While most studies have focused on the activation of the Nrf2 pathway after single chemical treatment, little is known about the dynamic regulation of the Nrf2 pathway in the context of repeated exposure scenarios. Here we employed single cell live imaging to quantitatively monitor the dynamics of the Nrf2 pathway during repeated exposure, making advantage of two HepG2 fluorescent protein reporter cell lines, expressing GFP tagged Nrf2 or sulfiredoxin 1 (Srxn1), a direct downstream target of Nrf2...
November 20, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30456485/comment-on-perinatal-exposure-to-a-glyphosate-based-herbicide-impairs-female-reproductive-outcomes-and-induces-second-generation-adverse-effects-in-wistar-rats
#18
LETTER
https://www.readbyqxmd.com/read/30448865/the-protective-role-of-liver-x-receptor-lxr-during-fumonisin-b1-induced-hepatotoxicity
#19
Marion Régnier, Arnaud Polizzi, Céline Lukowicz, Sarra Smati, Frédéric Lasserre, Yannick Lippi, Claire Naylies, Joelle Laffitte, Colette Bétoulières, Alexandra Montagner, Simon Ducheix, Pascal Gourbeyre, Sandrine Ellero-Simatos, Sandrine Menard, Justine Bertrand-Michel, Talal Al Saati, Jean-Marc Lobaccaro, Hester M Burger, Wentzel C Gelderblom, Hervé Guillou, Isabelle P Oswald, Nicolas Loiseau
Fumonisin B1 (FB1), a congener of fumonisins produced by Fusarium species, is the most abundant and most toxicologically active fumonisin. FB1 causes severe mycotoxicosis in animals, including nephrotoxicity, hepatotoxicity, and disruption of the intestinal barrier. However, mechanisms associated with FB1 toxicity are still unclear. Preliminary studies have highlighted the role of liver X receptors (LXRs) during FB1 exposure. LXRs belong to the nuclear receptor family and control the expression of genes involved in cholesterol and lipid homeostasis...
November 17, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30446774/highlight-report-spheroids-from-stem-cell-derived-hepatocyte-like-cells
#20
EDITORIAL
Patrick Nell
No abstract text is available yet for this article.
November 16, 2018: Archives of Toxicology
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