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Acta Medica Okayama

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https://www.readbyqxmd.com/read/29674772/total-hip-arthroplasty-for-patients-with-residual-poliomyelitis-at-a-mean-eight-years-of-follow-up
#1
Mayumi Sonekatsu, Motoki Sonohata, Masaru Kitajima, Shunsuke Kawano, Masaaki Mawatari
In patients with poliomyelitis, degenerative arthritis of the hip may be encountered in the paralytic or normal contralateral limb because of leg length discrepancy, pelvic obliquity, or severe deformities of the affected hip. Although total hip arthroplasty (THA) is one of the most common orthopedic procedures, there are few reports of THA in adult patients with residual poliomyelitis. From March 2001 to January 2011, 5 patients with residual poliomyelitis (6 hips) underwent THA using uncemented implants at our hospital...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674771/high-dose-dexamethasone-therapy-as-the-initial-treatment-for-idiopathic-thrombocytopenic-purpura-protocol-for-a-multicenter-open-label-single-arm-trial
#2
Ken Takase, Akiko Kada, Hiromi Iwasaki, Isao Yoshida, Morio Sawamura, Nobuyuki Yoshio, Shinichiro Yoshida, Hiroatsu Iida, Maki Otsuka, Toshiro Takafuta, Yuko Ogata, Youko Suehiro, Yukio Hirabayashi, Terutoshi Hishita, Chikamasa Yoshida, Takuo Ito, Michihiro Hidaka, Ikuyo Tsutsumi, Akiko M Saito, Hirokazu Nagai
Standard therapy for idiopathic thrombocytopenic purpura (ITP) has not been established. We are conducting a multicenter, prospective trial to determine the efficacy and safety of short-term, high-dose dexamethasone therapy in ITP patients aged 18-80 years with platelet counts of <20, 000 /μL, or with <50, 000/ μL and bleeding symptoms. The primary endpoints of this trial are the proportion of responses (complete plus partial response) on day 180 (day 46+180) after the completion of the 46-day high-dose dexamethasone therapy...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674770/incidence-of-pulmonary-complications-with-the-prophylactic-use-of-high-flow-nasal-cannula-after-pediatric-cardiac-surgery-prophylactic-hfnc-study-protocol
#3
Naohiro Shioji, Tomoyuki Kanazawa, Tatsuo Iwasaki, Kazuyoshi Shimizu, Tomohiko Suemori, Hirokazu Kawase, Satoshi Kimura, Yasutoshi Kuroe, Hiroshi Morimatsu
We will investigate the incidence of postoperative pulmonary complications (PPCs) with the prophylactic use of a high-flow nasal cannula (HFNC) after pediatric cardiac surgery. Children < 48 months old with congenital heart disease for whom cardiac surgery is planned will be included. The HFNC procedure will be commenced just after extubation, at a flow rate of 2 L/kg/min with adequate oxygen concentration to achieve target oxygen saturation ≥ 94%. This study will reveal the prevalence of PPCs after pediatric cardiac surgery with the prophylactic use of HFNC...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674769/helicobacter-cinaedi-associated-carotid-arteritis
#4
Shinichiro Nakao, Hideharu Hagiya, Keigo Kimura, Tomomi Mitsui, Akane Oyama, Kazuhiro Hongyo, Yusuke Takahashi, Futoshi Nakagami, Kazunori Tomono, Hiromi Rakugi
A 65-year-old Japanese man with bilateral carotid atherosclerosis presented with right neck pain and fever. Contrast-enhanced computed tomography suggested carotid arteritis, and carotid ultrasonography showed an unstable plaque. The patient developed a cerebral embolism, causing a transient ischemic attack. Helicobacter cinaedi was detected in blood culture, and H. cinaedi-associated carotid arteritis was diagnosed. Empirical antibiotic therapy was administered for 6 weeks. After readmission for recurrent fever, he was treated another 8 weeks...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674768/a-case-of-psoriasis-complicated-by-breast-cancer-after-systemic-treatments-including-biologics
#5
Shin Morizane, Saeko Sugimoto, Takayuki Motoki, Norihisa Katayama, Masako Omori, Keiji Iwatsuki
Psoriasis is a common chronic inflammatory skin disorder that is characterized by scaly, erythematous, sharply demarcated plaques. The treatment for psoriasis has dramatically changed over the last 10 years with the introduction of biologics. However, the risk of cancer induced by biologics for psoriasis has not been fully analyzed, since these agents have such a short history of use. Here we report the case of a 74-year-old woman with psoriasis vulgaris and psoriatic arthritis complicated by breast cancer after systemic treatments including etretinate, cyclosporine, methotrexate, adalimumab, and ustekinumab...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674767/portal-venous-gas-following-ingestion-of-hydrogen-peroxide-successfully-treated-with-hyperbaric-oxygen-therapy
#6
Chika Tsuboi, Hiromichi Naito, Shingo Hagioka, Hiroaki Hanafusa, Takahiro Hirayama, Yoshinori Kosaki, Atsuyoshi Iida, Tetsuya Yumoto, Kohei Tsukahara, Naoki Morimoto, Atsunori Nakao
The primary toxicity of hydrogen peroxide results from its interaction with catalase, which liberates water and oxygen. We report the case of a 14-year-old Japanese girl with portal venous gas that was caused by oxygen liberated from intentionally ingested hydrogen peroxide. Although she had a past history of atrial septal defect, recovery without cardiac or neurological sequelae was achieved using hyperbaric oxygen therapy. Emergency physicians must be aware of the danger of liberated oxygen due to hydrogen peroxide ingestion...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674766/the-combination-of-gemcitabine-cisplatin-and-paclitaxel-as-salvage-chemotherapy-for-advanced-urothelial-carcinoma
#7
Takeshi Hirata, Masanori Hanamoto, Kazuma Ogura, Nobuki Hayashi, Kosuke Takamura, Kohei Edamura, Shin Ebara, Takashi Saika
There is no standard second-line or salvage treatment for advanced urothelial carcinoma (UC). Here we investigated the efficacy and safety of gemcitabine, cisplatin, and paclitaxel (GCP) combination chemotherapy as salvage chemotherapy for advanced UC. We retrospectively analyzed the cases of 23 patients with advanced UC who showed progression or recurrence after cisplatin-based chemotherapy. Gemcitabine (1000 mg/m2), and paclitaxel (80 mg/m2) were administered on days 1 and 8. Cisplatin (70 mg/m2) was administered on day 1...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674765/clinical-and-functional-significance-of-intracellular-and-extracellular-microrna-25-3p-in-osteosarcoma
#8
Aki Yoshida, Tomohiro Fujiwara, Koji Uotani, Takuya Morita, Masahiro Kiyono, Suguru Yokoo, Joe Hasei, Eiji Nakata, Toshiyuki Kunisada, Toshifumi Ozaki
Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients' serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674764/image-quality-of-the-coronary-angiography-with-noise-reduction-technology-to-decrease-the-radiation-dose
#9
Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Keisuke Otsuki, Nobuyuki Miyake, Shinji Osumi, Kiyonori Yamaoka
We examined the effects of a reduced exposure dose on the quality of images from an angiography device augmented with a noise reduction algorithm. Before its clinical application, we compared the diameter of the discrimination limit of the hole with that in the conventional method by a visual evaluation with a contrast-detail (C-D) phantom imaged using the target dose. Based on the results, a reducible dose was determined and applied clinically. The sample population consisted of patients being followed up after percutaneous coronary intervention (PCI) for coronary artery disease; we evaluated the effects of the exposure reduction on image quality...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674763/descriptive-study-of-gender-dysphoria-in-japanese-individuals-with-male-to-female-gender-identity-disorder
#10
Yoshie Shinohara, Mikiya Nakatsuka
We focus on Japanese individuals with gender identity disorder (GID), especially male-to-female (MTF) GID, who have experienced difficulty in adapting to social life. We clarify what gender dysphoria is, and we examine methods of intervention. Semi-structured interviews were conducted with 11 individuals with MTF-GID from August 2015 to April 2017. We categorized the subjects'experiences regarding dysphoria into the 'Onset of gender dysphoria,' 'Experience of feeling gender dysphoria,' and 'Changes due to receiving medical care...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674762/current-multidisciplinary-approach-to-fertility-preservation-for-breast-cancer-patients
#11
Yuko Takahashi, Tadahiko Shien, Ai Sakamoto, Yuko Tsuyumu, Ryo Yoshioka, Maya Uno, Minami Hatono, Mariko Kochi, Kengo Kawada, Takahiro Tsukioki, Takayuki Iwamoto, Hirokuni Ikeda, Naruto Taira, Junji Matsuoka, Mikiya Nakatsuka, Hiroyoshi Doihara
Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674761/impact-of-body-mass-index-on-survival-of-pancreatic-cancer-patients-in-japan
#12
Tomohiro Okura, Masakuni Fujii, Junji Shiode, Yuri Ito, Toru Kojima, Junichiro Nasu, Takefumi Niguma, Masao Yoshioka, Tetsushige Mimura, Kazuhide Yamamoto
The impact of body mass index (BMI) on postoperative survival in Japanese patients with pancreatic cancer is unclear. We examined the relationship between preoperative BMI and the prognosis of Japanese patients who underwent surgery for pancreatic cancer to determine whether BMI affects these patients' prognosis. Of the patients who underwent pancreatectomy between January 2004 and August 2015 at our institution, 246 were pathologically diagnosed with pancreatic tubular adenocarcinoma; the cancer was located in the pancreatic head (n=161) and in the body and tail (n=85)...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674760/relationship-between-eating-quickly-and-overweight-a-cohort-study-of-schoolchildren-in-japan
#13
Hirotaka Ochiai, Takako Shirasawa, Hinako Nanri, Rimei Nishimura, Hiromi Hoshino, Akatsuki Kokaze
Several cross-sectional studies have shown that eating quickly is associated with overweight in children and adolescents. However, few cohort studies have examined this relationship. Here we investigated the relationship between eating quickly and overweight in a cohort study of fourth-grade schoolchildren (aged 9 or 10 years) who attended elementary schools in Ina-town, Japan. The children were followed for 3 years from 2001-2004 (at baseline) to 2004-2007. A questionnaire survey including information about eating speed (fast, medium, or slow) was administered, and height and weight measurements were obtained at baseline and follow-up...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674759/formulae-based-on-biomathematics-to-estimate-the-standard-value-of-fetal-growth-of-japanese
#14
Yasunari Miyagi, Katsuhiko Tada, Riko Takayoshi, Nobutsugu Oguni, Yasushi Sato, Maki Shibata, Machiko Kiyokawa, Tadashi Hashimoto, Tomoyoshi Takada, Takashi Oda, Takahito Miyake
We devised biomathematics-based formulae to estimate the standard values of fetal growth of Japanese after 22 weeks' gestation. The growth rates of bi-parietal diameter (BPD), abdominal circumference (AC), femur length (FL), and estimated fetal body weight (EFBW) at the time of gestation were assumed to be proportional to the product of the value at the time and the rest value of an unknown maximum value, respectively. The EFBW was also assumed to follow a multiple logistic function of BPD, AC and FL to fit the standard values of Japanese fetuses published by the Japan Society of Ultrasonics in Medicine...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674758/evaluation-of-the-upper-gastrointestinal-tract-in-ulcerative-colitis-patients
#15
Ryo Kato, Masaya Iwamuro, Sakiko Hiraoka, Shiho Takashima, Toshihiro Inokuchi, Masahiro Takahara, Yoshitaka Kondo, Takehiro Tanaka, Hiroyuki Okada
To analyze the clinical characteristics of patients with ulcerative colitis who have upper gastrointestinal lesions, we retrospectively reviewed the data of 216 patients with ulcerative colitis who underwent esophagogastroduodenoscopy at our institute in April 2008-March 2016. We investigated the endoscopic features and compared the clinical characteristics between the patients with and without upper gastrointestinal lesions. Forty-two patients (19.4%) had upper gastrointestinal lesions, including multiple erosions (n=18), bamboo joint-like appearance (n=17), mucosa with white spots (n=4), friable mucosa (n=2), ulcer (n=1), and purulent deposits within the mucosa (n=1) in the stomach and/or duodenum...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674757/ten-initial-cases-of-peroral-endoscopic-myotomy-for-treatment-of-esophageal-motility-disorders-at-okayama-university-hospital
#16
Yuusaku Sugihara, Keita Harada, Ryo Kato, Kenji Yamauchi, Shiho Takashima, Daisuke Takei, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Sakiko Hiraoka, Hiroyuki Okada
Peroral endoscopic myotomy (POEM) for treatment of esophageal motility disorders has recently been reported to be highly effective and less invasive than other treatment. POEM was recently introduced in Okayama University Hospital under the supervision of a physician from a high-volume center. To verify the safety and efficacy of POEM during its introduction in our institution. We examined 10 cases in whom POEM was performed between January 2016 and April 2017. The patients included 7 men and 3 women, with a median age (range) of 49 years (17-74) and median symptom duration of 6 years (1-21)...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29463947/randomized-controlled-trial-of-epidural-versus-patient-controlled-intravenous-analgesia-for-postoperative-pain-control-after-laparoscopic-gastrectomy
#17
Satoru Kikuchi, Shinji Kuroda, Masahiko Nishizaki, Takashi Matsusaki, Toshiharu Mitsuhashi, Kazuya Kuwada, Shunsuke Kagawa, Hiroshi Morimatsu, Toshiyoshi Fujiwara
Although epidural analgesia (EDA) is considered standard postoperative analgesia for open gastrectomy, it has been unclear whether EDA has benefits in laparoscopic gastrectomy (LG) because postoperative pain after a laparoscopic procedure is significantly reduced. We are conducting a two-arm, single-center, prospective randomized non-inferiority trial to evaluate the postoperative pain relief of patient-controlled intravenous analgesia (PCIA) compared to EDA. A total of 132 patients undergoing LG will be randomized to EDA and PCIA groups (n=64 each) for postoperative pain control...
February 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29463946/extensive-bilateral-patellar-tendon-ossification-in-a-spinal-cord-injury-patient
#18
Norio Yamamoto, Takaaki Miki, Akihiro Nishiyama, Tomoyuki Dan'ura, Yuzuru Matsui, Toshifumi Ozaki
This is the first report of extensive bilateral patellar tendon ossification occurring over a prolonged time after a unilateral knee injury. An 84-year-old Japanese man with a spinal cord injury caused by a burst fracture of the T12 vertebra presented with a bony hard prominence on the left knee, which was injured in a traffic accident when he was 77 years old. Radiography revealed extensive ossification of the bilateral patellar tendons. We review the English literature with a focus on the localization of bilateral heterotopic ossification of the knee in patients who had a central nervous system injury...
February 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29463945/traumatic-globe-luxation-with-complete-optic-nerve-transection-caused-by-heavy-object-compression
#19
Yoshinori Kosaki, Tetsuya Yumoto, Hiromichi Naito, Nobushige Tsuboi, Masahiro Kameda, Masayuki Hirano, Yuki Morizane, Takaya Senoo, Eijirou Tokuyama, Atsunori Nakao
Traumatic eyeball luxation is a rare clinical condition with a dramatic presentation. Here, we describe a unique case of traumatic globe luxation and complete optic nerve transection caused by heavy object compression. A 45-year-old male automobile mechanic was injured when a truck slipped from its supports, crushing his head and face. On arrival, his right eyeball was obviously displaced anteriorly and he had no light perception. Computed tomography revealed complex frontal bone and facial fractures with underlying brain contusion in addition to complete transection of the right optic nerve...
February 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29463944/laparoscopic-surgery-for-small-bowel-obstruction-due-to-paracecal-hernia
#20
Hiroki Otani, Shigeki Makihara
Internal hernia related to paracecal hernia is a rare disease and is difficult to confirm by preoperative diagnosis. We recently encountered a case of an 83-year-old woman who had lower abdominal pain in her right quadrant. Based on physical findings and CT findings she was diagnosed as having small bowel obstruction by internal hernia around the cecum. She underwent emergency operation with laparoscopic surgery and was diagnosed with a paracecal hernia and treated laparoscopically. After we dissected the ventral wall of the hernia sac and enlarged the hernia orifice, we reduced the trapped small intestine into the abdominal space...
February 2018: Acta Medica Okayama
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