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Acta Medica Okayama

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https://www.readbyqxmd.com/read/28824193/a-multicenter-prospective-randomized-controlled-trial-evaluating-the-efficacy-of-rectal-diclofenac-and-sublingual-nitrate-as-a-combined-prophylactic-treatment-for-post-ercp-pancreatitis
#1
Takeshi Tomoda, Hironari Kato, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada
Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography(ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitrate might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitrate for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824192/robotic-renal-autotransplantation-first-case-outside-of-north-america
#2
Motoo Araki, Koichiro Wada, Yosuke Mitsui, Takuya Sadahira, Risa Kubota, Shingo Nishimura, Takashi Yoshioka, Yuichi Ariyoshi, Kei Fujio, Atsushi Takamoto, Morito Sugimoto, Katsumi Sasaki, Yasuyuki Kobayashi, Shin Ebara, Hideki Taninishi, Hiroyuki Amano, Masashi Inui, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu
A 38-year-old woman with a 2.7-cm left ureteral stenosis requiring chronic ureteral stent exchange elected to undergo robotic renal autotransplantation. Left ureteropelvic junction obstruction (UPJO) was also suspected. Robotic donor nephrectomy contributed to the fine dissection for desmoplastic changes. The kidney was removed through a Gelport and examined on ice. UPJO was not seen. An end-to-side robotic anastomosis was created between the renal and external iliac vessels. The console time was 507 min, and the warm ischemia time was 4 min 5 sec...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824191/cervical-spine-osteoradionecrosis
#3
Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Yoshihiro Kimata, Toshifumi Ozaki
Osteoradionecrosis (ORN), a well-known complication of radiotherapy in the mandibular bone, is very rare in the cervical spine. The authors report the result of a 3-year follow-up of a 63-year-old female patient with ORN of the cervical spine. The patient had a history of laryngeal carcinoma and was treated with chemotherapy and radiation therapy with a total of 120 Gy. Eight years later, she developed acute, severe neck pain due to cervical spine necrosis. The authors performed vascularized fibular bone graft and posterior pedicle screw fixation to reconstruct her cervical spine...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824190/a-case-of-dermatomyositis-with-severe-myalgia-and-muscle-weakness-testing-positive-for-anti-melanoma-differentiation-associated-gene-5-antibody
#4
Kenji Yamazaki, Hiroshi Wakabayashi, Yu Suganami, Shinichi Sano, Yu Wakunami, Takashi Katayama, Kentaro Deguchi, Shoko Nagotani, Masayuki Kishida
We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824189/safety-and-efficacy-of-the-surgical-management-of-hemodialysis-patients-with-gastric-cancer
#5
Yusuke Otani, Takehiro Okabayashi, Yasuo Shima, Yuichi Shibuya, Kazuhide Ozaki, Jun Iwata, Sojiro Morita, Tatsuo Iiyama
This retrospective study evaluated the short- and long-term outcomes after surgical management for gastric cancer in hemodialysis patients compared to non-dialysis patients. Twelve hemodialysis patients were compared with a propensity score-matched cohort of 39 gastric cancer patients who had not undergone hemodialysis. Short- and long-term outcomes along with scores estimating physiological ability and surgical stress were evaluated in both groups. The incidence of postoperative morbidity according to the Clavien-Dindo classification was higher in the hemodialysis gastric cancer group than in the non-dialysis gastric cancer group...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824188/further-molecular-analysis-of-g6pd-deficiency-variants-in-southern-vietnam-and-a-novel-variant-designated-as-g6pd-ho-chi-minh-173-a-g-58-asp-gly-frequency-distributions-of-variants-compared-with-those-in-other-southeast-asian-countries
#6
Fumihiko Kawamoto, Hiroyuki Matsuoka, Nghiem Minh Pham, Taeko Hayashi, Yuichi Kasahara, Nguyen The Dung, Yasutoshi Kido, Toshio Kanbe, Indah S Tantular
We conducted a survey of glucose-6-phosphate dehydrogenase (G6PD) deficiency among newborn babies at Tu Du Hospital, Ho Chi Minh, southern Vietnam. A total of 90 deficient babies were detected, including 85 in the Kinh ethnic group, 4 Chinese, and 1 in the K'Ho minority group. In the Kinh ethnic group, G6PD variants such as G6PD Viangchan (n=32), Kaiping (n=11), Canton (n=8), Chinese-5 (n=7), Union (n=5) and Quing Yuan (n=4) were detected. A variant with silent mutations at 1311 C>T and IVS11 nt 93 T>C was also detected in 17 cases...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824187/residual-femoral-deformity-and-femoroacetabular-impingement-after-intertrochanteric-osteotomy-for-slipped-capital-femoral-epiphysis
#7
Yosuke Fujii, Hirosuke Endo, Shigeru Mitani, Hirofumi Akazawa, Tomonori Tetsunaga, Takamasa Miyake, Kazuki Yamada, Kiyoshi Aoki, Toshifumi Ozaki
We retrospectively reviewed 29 hips in which intertrochanteric osteotomies were performed for severe slipped capital femoral epiphyses. Mean age at surgery: 12.6 years. Mean follow-up period: 6 years. At the final follow-up evaluation, one patient had coxalgia, and six hips showed a limited range of motion. A pistol-grip deformity was observed in 13 hips, osteoarthritis in two hips, and a bump existed in 19 hips on the latest radiographs. Gradual remodeling of the bumps was observed post-operatively in 22 hips...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824186/comparison-of-psychological-distress-between-type-2-diabetes-patients-with-and-without-proteinuria
#8
Rie Asakura, Nobuyuki Miyatake, Kazumi Dokai Mochimasu, Risa Kurato, Susumu Kuwana
We investigated the link between proteinuria and psychological distress among patients with type 2 diabetes mellitus (T2DM). A total of 130 patients with T2DM aged 69.1±10.3 years were enrolled in this cross-sectional study. Urine and blood parameters, age, height, body weight, and medications were analyzed, and each patient's psychological distress was measured using the six-item Kessler Psychological Distress Scale (K6). We compared the K6 scores between the patients with and without proteinuria. Forty-two patients (32...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824185/a-strategic-protocol-to-improve-the-process-and-outcomes-of-two-stage-revision-total-hip-arthroplasty
#9
Takaya Taniguchi, Wataru Taniguchi, Erabu Miyamoto, Nobuyuki Miyazaki, Munehito Yoshida
Two-stage revision total hip arthroplasty (THA) is the most commonly used treatment approach for deep prosthetic infection. However, in this approach the interval between the first and second stage tends to be prolonged. We devised a strategic protocol for improving the infection eradication rate and shortening the interval between the stages in two-stage revision THA. This study analyzed a series of 14 patients (14 hips) from 2008 to 2012, who were treated using an antibiotic-loaded acrylic cement (ALAC) spacer at the first stage and re-implantation at the second stage...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824184/association-between-skeletal-muscle-depletion-and-sorafenib-treatment-in-male-patients-with-hepatocellular-carcinoma-a-retrospective-cohort-study
#10
Atsushi Naganuma, Takashi Hoshino, Yuhei Suzuki, Daisuke Uehara, Tomohiro Kudo, Hiroshi Ishihara, Ken Sato, Satoru Kakizaki, Masanobu Yamada, Hitoshi Takagi
The effect of skeletal muscle mass (SMM) on the outcomes of sorafenib treatment for hepatocellular carcinoma (HCC) has not been established. We measured the SMM in HCC patients treated with sorafenib, evaluated the patients' survival, and evaluated the association between skeletal muscle depletion and sorafenib treatment. Of the 97 HCC patients treated with sorafenib at our institution in the period from July 2009 to February 2015, our study included 69 patients (51 males, 18 females) who had received sorafenib for ≥ 8 weeks and whose follow-up data were available...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824183/an-analysis-of-the-characteristics-and-improved-use-of-newly-developed-ct-based-navigation-system-in-total-hip-arthroplasty
#11
Yosuke Fujii, Kazuo Fujiwara, Tomonori Tetsunaga, Takamasa Miyake, Kazuki Yamada, Hirosuke Endo, Nobuhiro Abe, Naohiko Sugita, Mamoru Mitsuishi, Takayuki Inoue, Yoshio Nakashima, Toshifumi Ozaki
We developed a surface matching-type computed tomography (CT)-based navigation system for total hip arthroplasty (the N-navi; TEIJIN NAKASHIMA MEDICAL, Okayama, Japan). In the registration step, surface matching was performed with digitizing points on the pelvic bone surface after coarse paired matching. In the present study, we made model bones from the CT data of patients whose acetabular shapes had various deformities. We measured the distances and angles after surface matching from the fiducial points and evaluated the ability to correct surface-matching registration on each pelvic form, using several areas and numbers of points...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824182/analysis-of-the-postoperative-displacement-of-trochanteric-fractures-on-lateral-view-radiographs
#12
Atsuo Furui, Nobuki Terada
Achieving sufficient support of the anterior cortex of the femoral neck is a fundamental goal of the reduction of trochanteric fractures. However, anterior-cortex support is often lost after the fracture reduction. Our aim was to analyze factors contributing to the postoperative displacement of an acceptably reduced trochanteric fracture. The cases of 40 patients with a post-reduction Ikuta subtype N fracture alignment were reviewed. All fractures were fixed with 135° free-sliding plates. On postoperative day 14, patients were classified into two groups: those with retention of the Ikuta subtype N alignment, and those with progression to Ikuta subtype P alignment...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28824181/mesenchymal-stem-cell-therapy-for-ischemic-stroke
#13
REVIEW
Atsuhiko Toyoshima, Takao Yasuhara, Isao Date
 To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke...
August 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655947/reconstruction-of-anterior-chest-wall-with-polypropylene-mesh-two-primary-sternal-chondrosarcoma-cases
#14
Shinichi Kawana, Hiromasa Yamamoto, Yuho Maki, Seiichiro Sugimoto, Shinichi Toyooka, Shinichiro Miyoshi
 Primary sternal chondrosarcoma is a rare malignant tumor that is refractory to chemotherapy and radiation. Effective therapy is radical resection of the tumor. We present two patients with primary sternal chondrosarcoma who underwent a radical resection of the lower half of the sternum and bilateral ribs, followed by reconstruction with 2 sheets of polypropylene mesh layered orthogonally. The patients have maintained almost the same pulmonary function as preoperative values, with stability of the chest wall...
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655946/autologous-internal-limiting-membrane-transplants-successfully-close-a-large-parafoveal-retinal-hole
#15
Fumiaki Kumase, Yuki Morizane, Shuhei Kimura, Shinji Toshima, Fumio Shiraga
 Parafoveal retinal holes (PRHs) are one of the complications that can occur after internal limiting membrane (ILM) peeling during macular surgery. Here we describe a patient in whom an exceptionally large PRH (1,069-μm dia.) was successfully closed by repeated autologous ILM transplantation.
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655945/a-case-of-refractory-langerhans-cell-histiocytosis-complicated-with-hemophagocytic-lymphohistiocytosis-rescued-by-cord-blood-transplantation-with-reduced-intensity-conditioning
#16
Kana Washio, Michiko Muraoka, Kiichiro Kanamitsu, Megumi Oda, Akira Shimada
 We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years...
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655944/importance-of-second-look-endoscopy-on-an-empty-stomach-for-finding-gastric-bezoars-in-patients-with-gastric-ulcers
#17
Masaya Iwamuro, Shouichi Tanaka, Yuki Moritou, Tomoki Inaba, Reiji Higashi, Chiaki Kusumoto, Naoko Yunoki, Shin Ishikawa, Yuko Okamoto, Yoshinari Kawai, Ken-Ichi Kitada, Ryuta Takenaka, Tatsuya Toyokawa, Hiroyuki Okada
 Most gastric bezoars can be treated with endoscopic fragmentation combined with or without cola dissolution, whereas laparotomy or laparoscopic surgery is generally inevitable for small intestinal bezoars because they cause small bowel obstruction. Therefore, early diagnosis and management of gastric bezoars are necessary to prevent bezoar-induced ileus. To investigate the incidence of overlooked gastric bezoars during the initial esophagogastroduodenoscopy, we retrospectively reviewed the cases of 27 patients diagnosed with gastrointestinal bezoars...
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655943/lesion-size-on-ultrasonography-predicts-potential-invasion-in-ductal-carcinoma-in-situ-preoperatively-diagnosed-by-breast-needle-biopsy
#18
Kyoko Shimoyama, Tomo Osako, Toshiharu Mitsuhashi, Futoshi Akiyama, Takuji Iwase
Ductal carcinoma in situ (DCIS) of the breast has no potential to metastasize, but over 20% of cases preoperatively diagnosed as DCIS are upstaged on final pathology. The rates of upstaging and the predictors for invasion on final pathology were evaluated. For 240 primary breast cancers, radiological findings on mammography, ultrasonography, and magnetic resonance imaging were investigated along with pathological and clinical information. Univariate and multivariate analyses were performed to identify predictors of potential invasion...
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655942/diagnostic-ureteroscopy-for-cases-clinically-suspected-of-carcinoma-in-situ-of-the-upper-urinary-tract
#19
Katsumi Sasaki, Koichiro Wada, Motoo Araki, Yasuyuki Kobayashi, Morito Sugimoto, Shin Ebara, Toyohiko Watanabe, Yasutomo Nasu
 We elucidate the fate of cases clinically suspected of carcinoma in situ (Cis) of the upper tract with serial ureteroscopy. Of 143 patients who underwent ureteroscopy for suspected upper tract urothelial carcinoma (UTUC) between January 2008 and February 2016, 12 cases with consistently positive urine cytology and poorly detectable upper-tract malignancies by imaging were reviewed. In these 12 patients, 19 ureteroscopy procedures (25 renal units) were performed. Vesical random biopsy was performed before the 1st ureteroscopy to exclude malignancy of the bladder in all 12 cases...
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655941/the-immunological-impact-of-chemotherapy-on-the-tumor-microenvironment-of-oral-squamous-cell-carcinoma
#20
Hiroaki Takakura, Shohei Domae, Toshiro Ono, Akira Sasaki
 Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment...
June 2017: Acta Medica Okayama
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