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Acta Medica Okayama

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https://www.readbyqxmd.com/read/30140096/an-open-label-single-arm-trial-of-a-novel-extramedullary-guide-coordinated-with-3d-surgical-assistive-software-for-total-knee-arthroplasty
#1
Daihei Kida, Hiroya Hashimoto, Akiko M Saito, Yukari Kito, Kouichi Mori, Kenya Terabe, Nobunori Takahashi, Yasushi Tomita
There is no assistive device for extramedullary surgery coordinated with 3D surgical assistive software for the total knee arthroplasty (TKA). We developed a novel extramedullary universal guide coordinated with 3D surgical assistive software and a novel extramedullary patient-specific assistive guide for the placement of femoral components by referring to an area not affected by cartilage or bone spurs, and filed a patent application. In this study, we visualize and reconstruct the total alignment of the lower extremity in TKA using these surgical devices, and validate their precision...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140095/the-effect-of-interim-fdg-pet-guided-response-adapted-therapy-in-pediatric-patients-with-hodgkin-s-lymphoma-hl-14-protocol-for-a-phase-ii-study
#2
Yuhki Koga, Shingo Baba, Reiji Fukano, Katsumasa Nakamura, Toshinori Soejima, Naoko Maeda, Shosuke Sunami, Junichi Ueyama, Tetsuo Mitsui, Takeshi Mori, Tomoo Osumi, Masahiro Sekimizu, Kentaro Ohki, Fumiko Tanaka, Michi Kamei, Naoto Fujita, Tetsuya Mori, Akiko M Saito, Akiko Kada, Ryoji Kobayashi
This trial enrolls patients with untreated Hodgkin's lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140094/a-phase-i-ii-study-of-crizotinib-for-recurrent-or-refractory-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-and-a-phase-i-study-of-crizotinib-for-recurrent-or-refractory-neuroblastoma-study-protocol-for-a-multicenter-single-arm-open-label
#3
Masahiro Sekimizu, Tomoo Osumi, Reiji Fukano, Yuhki Koga, Akiko Kada, Akiko M Saito, Tetsuya Mori
Crizotinib is an inhibitor of multiple tyrosine kinases, including the anaplastic lymphoma kinase (ALK). Responses to crizotinib have also been reported in patients with ALK-positive anaplastic large-cell lymphoma (ALCL) and solid tumors with ALK-mutation, including neuroblastoma. Optimal treatment for patients with recurrent or refractory ALK-positive ALCL and neuroblastoma has not been established. There is a need to develop new drugs for these patients. The objectives of this trial are to evaluate the tolerability and safety of crizotinib in Japanese patients with recurrent/refractory ALK-positive ALCL or neuroblastoma (phase I) and its efficacy in recurrent/refractory ALK-positive ALCL (phase II)...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140093/phase-ii-clinical-trial-for-newly-diagnosed-children-and-adolescents-with-localized-lymphoblastic-lymphoma-japanese-leukemia-lymphoma-study-group-trial-llb-nhl03-study-protocol-for-nationwide-multicenter-trial
#4
Masahiro Sekimizu, Junichiro Fujimoto, Tetsuya Takimoto, Masahito Tsurusawa, Keizo Horibe, Shosuke Sunami
Pediatric patients with lymphoblastic lymphoma are generally treated using the Berlin-Frankfurt-Munster (BFM) 90 protocol, which is the standard treatment strategy for pediatric acute lymphoblastic leukemia, and have a favorable outcome. However, this intense regimen includes high total doses of anthracycline and alkylating agents, and is known to cause late complications. We therefore planned a clinical trial to examine the efficacy and safety of a modified BFM regimen. We expect that this phase II, nationwide multicenter trial will help to establish an effective and safer standard therapy for stage I/II pediatric lymphoblastic lymphoma...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140092/study-design-of-a-phase-ii-clinical-trial-to-assess-the-efficacy-and-safety-of-eperisone-in-japanese-type-2-diabetes-patients-with-risk-and-non-risk-alleles-of-cdkal1
#5
Kourin Sakakida, Fan-Yan Wei, Takafumi Senokuchi, Seiya Shimoda, Tatsuyuki Kakuma, Eiichi Araki, Kazuhito Tomizawa
Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140091/microseizures-induced-by-topiramate
#6
Susumu Miyake, Makio Sugita, Tomio Okazaki, Mieko Takenaka, Kentarou Kuwabara, Kazunori Ogawa
A 22-year-old Japanese male with trisomy 21 was diagnosed with West syndrome at 4 months old. After the suppression of epileptic spasms using adrenocorticotropic hormone therapy, he had complex partial seizures and bilateral frontal epileptic discharges on EEG. Although the introduction of topiramate (TPM) decreased the seizures during wakefulness, frequent episodes of brief eye-opening appeared during sleep while the patient was taking TPM (400 mg/day). EEG showed fast activity at the times of eye-opening...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140090/development-of-gait-rehabilitation-system-capable-of-assisting-pelvic-movement-of-normal-walking
#7
Chanyul Jung, Suhun Jung, Min Ho Chun, Jong Min Lee, Shinsuk Park, Seung-Jong Kim
Gait rehabilitation training with robotic exoskeleton is drawing attention as a method for more advanced gait rehabilitation training. However, most of the rehabilitation robots are mainly focused on locomotion training in the sagittal plane. This study introduces a novel gait rehabilitation system with actuated pelvic motion to generate natural gait motion. The rehabilitation robot developed in this study, COWALK, is a lower-body exoskeleton system with 15 degrees of freedom (DoFs). The COWALK can generate multi-DoF pelvic movement along with leg movements...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140089/mixed-hcv-infection-of-genotype-1b-and-other-genotypes-influences-non-response-during-daclatasvir-asunaprevir-combination-therapy
#8
Nozomu Wada, Fusao Ikeda, Chizuru Mori, Koichi Takaguchi, Shin-Ichi Fujioka, Haruhiko Kobashi, Yoichi Morimoto, Kazuya Kariyama, Kosaku Sakaguchi, Noriaki Hashimoto, Akio Moriya, Mitsuhiko Kawaguchi, Hirokazu Miyatake, Hiroaki Hagihara, Junichi Kubota, Hiroki Takayama, Yasuto Takeuchi, Tetsuya Yasunaka, Akinobu Takaki, Yoshiaki Iwasaki, Hiroyuki Okada
Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140088/relationship-between-sedentary-behavior-and-health-related-quality-of-life-in-patients-on-chronic-hemodialysis
#9
Shuhei Hishii, Nobuyuki Miyatake, Hiroyuki Nishi, Akihiko Katayama, Kazuhiro Ujike, Kiichi Koumoto, Hiroo Hashimoto
We explored the relationship between sedentary behavior and the health-related quality of life (HRQOL) in patients on chronic hemodialysis. A total of 60 outpatients, aged 71.1±12.0 years, were enrolled in this cross-sectional study. Sedentary behavior was measured using a tri-accelerometer and HRQOL was evaluated by the Euro-QOL questionnaire (EQ-5D). The relationship between the patients' sedentary behavior and HRQOL was evaluated by simple and multiple correlation analyses. The relative sedentary behavior (%) for total days was 73...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140087/women-with-recurrent-pregnancy-loss-their-psychology-during-late-pregnancy-and-the-supportive-behavior-of-their-partners
#10
Kumiko Hada, Emiko Kuse, Mikiya Nakatsuka
To elucidate the psychiatric characteristics of mothers and the supportive behavior of their partners during late pregnancy, 131 mothers who gave birth at 2 general hospitals in City A between August 2009 and September 2010 (control group: n=90; recurrent pregnancy loss (RPL) group: n=41) completed a self-administered questionnaire on four separate occasions: during late pregnancy, during hospitalization, at 1-month postpartum, and at 3-months postpartum. The RPL group had significantly (p=0.03) lower anxiety regarding potential change in their appearance than the controls, but were more likely to worry about losing their baby (58% vs...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140086/impact-of-polyp-regression-on-2-year-outcomes-of-intravitreal-aflibercept-injections-a-treat-and-extend-regimen-for-polypoidal-choroidal-vasculopathy
#11
Mio Morizane-Hosokawa, Yuki Morizane, Shuhei Kimura, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga
We conducted intravitreal aflibercept injections (IVAs) for 37 Japanese patients (28 males, 9 females, mean age 73.4 years) with polypoidal choroidal vasculopathy (PCV), with a treat-and-extend regimen (TER). We evaluated the impact of polyp regression after a loading dose (2-mg IVA 1×/month for 3 months) on the patients' 2-year treatment outcomes. Thirty-seven eyes were treated with IVA by a TER for 2 years. We divided the patients into 2 groups based on their polyp status after the loading dose: polyp regression (PR+) (n=19) and no polyp regression (PR-) (n=18)...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140085/venous-thromboembolism-in-patients-with-acute-thoracolumbar-spinal-cord-injury
#12
Takuya Morita, Yoshihisa Sugimoto, Tomoyuki Takigawa, Haruo Misawa, Yasuo Ito, Toshifumi Ozaki
Venous thromboembolism (VTE) is a major complication in patients with acute spinal cord injury. There are few reports of VTE with acute thoracolumbar spinal cord injury (TLSCI). We assessed the incidence of VTE with acute TLSCI using color Doppler ultrasonography. We retrospectively assessed 75 patients with acute TLSCI (T1 to L1). All patients were surgically treated. VTE of the lower extremity and pelvis was assessed using color Doppler ultrasound regardless of whether symptoms were present. This retrospective study included patients who were assessed between 6 and 10 days (mean 8...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140084/hormonal-therapy-resistant-estrogen-receptor-positive-metastatic-breast-cancer-cohort-horse-bc-study-current-status-of-treatment-selection-in-japan
#13
Takayuki Iwamoto, Naruto Taira, Tomomi Fujisawa, Kazuhiro Araki, Kentaro Sakamaki, Takafumi Sangai, Yuichiro Kikawa, Tadahiko Shien, Shintaro Takao, Masako Sato, Yoshinari Goto, Takashi Yoshida, Masato Takahashi, Tomohiko Aihara, Hirofumi Mukai
The Hormonal therapy resistant estrogen-receptor positive metastatic breast cancer cohort (HORSE-BC) study is a multicenter observational study evaluating the efficacy and safety of secondary endocrine therapy (ET) for postmenopausal cases of metastatic breast cancer (MBC) with poor response to primary ET. In this initial report we analyze the HORSE-BC baseline data to clarify the current status of treatment selection for MBC in Japan. Baseline data for the 50 patients enrolled in HORSE-BC were analyzed, including patient characteristics, types of secondary ET, and reasons for selecting secondary ET...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140083/upregulation-of-angiogenic-factors-via-protein-kinase-c-and-hypoxia-induced-factor-1%C3%AE-pathways-under-high-glucose-conditions-in-the-placenta
#14
Takashi Mitsui, Kazumasa Tani, Jota Maki, Takeshi Eguchi, Shoko Tamada, Eriko Eto, Kei Hayata, Hisashi Masuyama
Abnormal glucose metabolism during pregnancy is an established risk factor for preeclampsia (PE). Disruption of the balance between placental angiogenic factors is linked to PE pathophysiology. We examined whether hypoxia-induced factor-1α (HIF-1α) and protein kinase Cβ (PKCβ) are involved in the regulation of placental angiogenic factors under high-glucose conditions in vitro. The human choriocarcinoma cell lines BeWo and JEG-3, and the human trophoblast cell line HTR-8/SVneo were cultured with 10 and 25 mmol/L glucose [control glucose group (CG) and high-glucose group (HG), respectively]...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140082/epidemiology-of-pediatric-acute-encephalitis-encephalopathy-in-japan
#15
Shinichiro Goto, Nobuyuki Nosaka, Takashi Yorifuji, Tomoaki Wada, Yosuke Fujii, Masato Yashiro, Yosuke Washio, Kosei Hasegawa, Hirokazu Tsukahara, Tsuneo Morishima
We studied the etiology of pediatric acute encephalitis/encephalopathy (pAEE) using epidemiological data obtained from a nationwide survey in Japan. Two-step questionnaires were sent to the pediatric departments of hospitals throughout the country in 2007, querying the number of the cases during 2005-2006 as the first step, and asking for the details of clinical information as the second step. In all, 636 children with pAEE (age ≤ 15 years) were enrolled. For the known etiology of pAEE (63.5% of the total cases), 26 microbes and 2 clinical entities were listed, but the etiology of 36...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140081/a-multidisciplinary-approach-to-the-management-of-chronic-pain-through-a-self-managed-behavioral-exercise-program-a-pilot-study-in-japan
#16
Hiroyuki Nishie, Tomoko Tetsunaga, Hirotaka Kanzaki, Koji Oda, Shinichiro Inoue, Yuta Ryuo, Haruyuki Ota, Takuya Miyawaki, Kyosuke Arakawa, Tomonori Tetsunaga, Yoshihisa Kitamura, Toshiaki Sendo, Hiroshi Morimatsu, Toshifumi Ozaki, Keiichiro Nishida
We conducted this study to determine the short-term treatment outcomes of multidisciplinary approaches to chronic pain management for outpatients in Japan. We evaluated pain reduction and improvement in quality of life (QOL) after treatment. We analyzed 32 patients who had experienced intractable chronic pain for > 3 months. The patients received multidisciplinary therapeutic self-managed exercise instructions and then underwent evaluations 1 and 3 months after the treatment. We used the Pain Disability Short Form-36 (SF-36), Pain Catastrophizing Scale (PCS), and Pain Disability Assessment Scale (PDAS) to evaluate QOL...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140080/relationship-between-chronic-low-back-pain-social-participation-and-psychological-distress-in-elderly-people-a-pilot-mediation-analysis
#17
Yutaka Owari, Nobuyuki Miyatake
Several studies indicated that chronic low back pain (CLBP) worsened psychological distress (PD) and social participation (SP) improved PD. The relationships among CLBP, SP and PD have not been established. Here we investigate whether SP mediates the relationship between CLBP and PD in 96 elderly people. We evaluated CLBP and SP by a self-administered questionnaire and PD by K6 questionnaires. We used simple correlation analyses, the unpaired t-test, and a mediation analysis following the approach outlined by Structural Equation Modeling (SEM) to clarify the relationships among CLBP, SP and PD...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140079/evaluation-of-setup-errors-at-the-skin-surface-position-for-whole-breast-radiotherapy-of-breast-cancer-patients
#18
Kanae Miyahara, Masahiro Kuroda, Yuuki Yoshimura, Hideki Aoyama, Masataka Oita, Irfan Sugianto, Hidenobu Matsuzaki, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Susumu Kanazawa, Junichi Asaumi
We used image-processing software to analyze the setup errors at the skin surface position of breast cancer patients (n=66) who underwent post-operative whole breast irradiation at our hospital in 2014-2015. The sixty-six digital reconstructed radiographs (DRR) were created at the treatment planning for each patient. The lineacgraphies (n=377) were taken after the patients' setup during radiotherapy. The lineacgraphies and DRR were superimposed at the skin surface position for each patient with the image-processing software...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/30140078/epileptic-high-frequency-oscillations-in-scalp-electroencephalography
#19
REVIEW
Takashi Shibata, Katsuhiro Kobayashi
Electroencephalography (EEG) examines the functional state of the brain. High-frequency oscillations (HFOs) in the ripple (80-200/250 Hz) and fast ripple (200/250-500/600 Hz) bands have recently been attracting attention, and their recording has been enabled by advancements in digital EEG techniques. The detection of HFOs was previously limited to intracranial EEG, but fast oscillations (FOs) in the gamma (40-80 Hz) and ripple bands can now be detected over the scalp. HFOs and FOs have been shown to be related to epileptogenicity in intracranial EEG and scalp EEG, respectively...
August 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29926012/randomized-phase-ii-study-comparing-mannitol-with-furosemide-for-the-prevention-of-renal-toxicity-induced-by-cisplatin-based-chemotherapy-with-short-term-low-volume-hydration-in-advanced-non-small-cell-lung-cancer-the-olcsg1406-study-protocol
#20
Go Makimoto, Eiki Ichihara, Katsuyuki Hotta, Kiichiro Ninomiya, Isao Oze, Daisuke Minami, Takashi Ninomiya, Toshio Kubo, Kadoaki Ohashi, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura
Although cisplatin-based chemotherapy shows a survival advantage compared to carboplatin for treating advanced non-small cell lung cancer, high-volume hydration and a long infusion time are necessary to avoid nephrotoxicity, and cisplatin-based chemotherapy has been difficult to administer in outpatient settings. A low-volume hydration method using mannitol or furosemide as forced diuresis was recently introduced, but there are no clear conclusions regarding which agent should be used. We describe our ongoing randomized phase II trial (the OLCSG1406 Study) evaluating the efficacy of forced diuresis...
June 2018: Acta Medica Okayama
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