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Haematologica

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https://www.readbyqxmd.com/read/28209659/hyperlipidemia-is-a-risk-factor-for-osteonecrosis-in-children-and-young-adults-with-acute-lymphoblastic-leukemia
#1
Signe Sloth Mogensen, Kjeld Schmiegelow, Kathrine Grell, Birgitte Klug Albertsen, Peder Skov Wehner, Peter Kampmann, Thomas Leth Frandsen
No abstract text is available yet for this article.
February 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28209658/relevance-of-id3-tcf3-ccnd3-pathway-mutations-in-pediatric-aggressive-b-cell-lymphoma-treated-according-to-the-nhl-bfm-protocols
#2
Marius Rohde, Bettina R Bonn, Martin Zimmermann, Jonas Lange, Anja Möricke, Wolfram Klapper, Ilske Oschlies, Monika Szczepanowski, Inga Nagel, Martin Schrappe, Markus Loeffler, Reiner Siebert, Alfred Reiter, Birgit Burkhardt
Mature B-cell Non-Hodgkin lymphoma is the most common subtype of Non-Hodgkin lymphoma in childhood and adolescence. B-cell Non-Hodgkin lymphoma are further classified into histological subtypes, with Burkitt lymphoma and Diffuse large B-cell lymphoma being the most common subgroups in pediatric patients. Translocations involving the MYC oncogene are known as relevant but not sufficient hit for Burkitt lymphoma pathogenesis. Recently published large-scale next-generation sequencing studies unveiled sets of additional recurrently mutated genes in samples of pediatric and adult B-cell Non-Hodgkin lymphoma patients...
February 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28209657/demystification-of-enigma-on-antigen-presenting-cell-features-of-human-basophils-data-from-secondary-lymphoid-organs
#3
Emmanuel Stephen-Victor, Mrinmoy Das, Meenu Sharma, Caroline Galeotti, Hélène Fohrer-Ting, Boualem Sendid, Luc Darnige, Benoit Terris, Cécile Badoual, Patrick Bruneval, Srini V Kaveri, Jagadeesh Bayry
No abstract text is available yet for this article.
February 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28209656/changes-in-allele-frequencies-of-csf3r-and-setbp1-mutations-and-evidence-of-clonal-evolution-in-a-chronic-neutrophilic-leukemia-patient-treated-with-ruxolitinib
#4
Zohra Nooruddin, Nicholas Miltgen, Qi Wei, Jeffrey Schowinsky, Zengang Pan, Jennifer Tobin, Enkhtsetseg Purev, Jonathan A Gutman, William Robinson, Daniel A Pollyea
No abstract text is available yet for this article.
February 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28209655/mutational-analysis-in-serial-marrow-samples-during-azacitidine-treatment-in-patients-with-post-transplant-relapse-of-acute-myeloid-leukemia-or-myelodysplastic-syndromes
#5
Janghee Woo, Nicholas P Howard, Barry E Storer, Min Fang, Cecilia C Yeung, Bart L Scott, H Joachim Deeg
No abstract text is available yet for this article.
February 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28183851/monitoring-multiple-myeloma-by-next-generation-sequencing-of-v-d-j-rearrangements-from-circulating-myeloma-cells-and-cell-free-myeloma-dna
#6
Anna Oberle, Anna Brandt, Minna Voigtlaender, Benjamin Thiele, Janina Radloff, Anita Schulenkorf, Malik Alawi, Nuray Akyüz, Manuela März, Christopher T Ford, Artus Krohn-Grimberghe, Mascha Binder
Recent studies suggest that circulating tumor cells and cell-free DNA may represent powerful non-invasive tools for disease monitoring in patients with solid and hematological malignancies. Here, we conducted a pilot study in 27 myeloma patients to explore the clonotypic V(D)J rearrangement for monitoring of circulating myeloma cells (cmc-V(D)J) and cell-free myeloma DNA (cfm-V(D)J). Next-generation sequencing was used to define the myeloma V(D)J rearrangement and for subsequent peripheral blood tracking after treatment initiation...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28183850/deltex-1-mutations-predict-poor-survival-in-diffuse-large-b-cell-lymphoma
#7
Leo Meriranta, Annika Pasanen, Riku Louhimo, Alejandra Cervera, Amjad Alkodsi, Matias Autio, Minna Taskinen, Ville Rantanen, Marja-Liisa Karjalainen-Lindsberg, Harald Holte, Jan Delabie, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä
No abstract text is available yet for this article.
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28183849/bone-marrow-mesenchymal-stromal-cells-induce-nitric-oxide-synthase-dependent-differentiation-of-cd11b-cells-that-expedite-hematopoietic-recovery
#8
Cristina Trento, Ilaria Marigo, Alice Pievani, Antonio Galleu, Luigi Dolcetti, Chun-Yin Wang, Marta Serafini, Vincenzo Bronte, Francesco Dazzi
Bone marrow microenvironment is fundamental for hematopoietic homeostasis. Numerous efforts have been made to reproduce or manipulate its activity to facilitate engraftment after hematopoietic stem cell transplantation but clinical results remain unconvincing. This probably reflects the complexity of the hematopoietic niche. Recent data have demonstrated the fundamental role of stromal and myeloid cells in regulating hematopoietic stem cell self-renewal and mobilization in the bone marrow. In this study we unveil a novel interaction by which bone marrow mesenchymal stromal cells induce the rapid differentiation of CD11b+ myeloid cells from bone marrow progenitors...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28183848/long-term-observation-reveals-high-frequency-engraftment-of-human-acute-myeloid-leukemia-in-immunodeficient-mice
#9
Anna M Paczulla, Stephan Dirnhofer, Martina Konantz, Michael Medinger, Helmut R Salih, Kathrin Rothfelder, Dimitrios A Tsakiris, Jakob R Passweg, Pontus Lundberg, Claudia Lengerke
Repopulation of immunodeficient mice remains the primary method to func-tionally assess human acute myeloid leukemia. Published data report en-graftment of ~40-66% of cases, mostly belonging to intermediate or poor risk subtypes. Here we report that extending follow-up beyond the standard analysis end-points of 10 to 16 weeks post-transplantation permitted leukemic engraftment from nearly every xenotransplanted acute myeloid leukemia case (18/19, ~95%). Xenogeneic leukemic cells showed conserved immune phenotypes and genetic signatures when compared to corresponding pre-transplant cells, and were furthermore able to induce leukemia in re-transplantation assays...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28183847/human-rhinovirus-detection-in-the-lower-respiratory-tract-of-hematopoietic-cell-transplant-recipients-association-with-mortality
#10
Sachiko Seo, Alpana Waghmare, Emily M Scott, Hu Xie, Jane M Kuypers, Robert C Hackman, Angela P Campbell, Su-Mi Choi, Wendy M Leisenring, Keith R Jerome, Janet A Englund, Michael Boeckh
Human rhinoviruses are the most common respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe lower respiratory tract infection in immunocompromised patients, the clinical significance of rhinovirus detection in the lower respiratory tract remains unknown. We evaluated 697 recipients transplanted between 1993 and 2015 with rhinovirus in respiratory samples. As comparative cohorts, 273 recipients with lower respiratory tract infection caused by respiratory syncytial virus (N=117), parainfluenza virus (N=120), or influenza (N=36) were analyzed...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28183846/association-between-quality-of-response-and-outcomes-in-patients-with-newly-diagnosed-mantle-cell-lymphoma-receiving-vr-cap-versus-r-chop-in-the-phase-iii-lym-3002-study
#11
Gregor Verhoef, Tadeusz Robak, Huiqiang Huang, Halyna Pylypenko, Noppadol Siritanaratkul, Juliana Pereira, Johannes Drach, Jiri Mayer, Rumiko Okamoto, Lixia Pei, Brendan Rooney, Andrew Cakana, Helgi van de Velde, Franco Cavalli
In the phase III LYM-3002 study comparing intravenous VR-CAP with R-CHOP in patients with newly-diagnosed, measurable stage II-IV mantle cell lymphoma, not considered, or ineligible for, transplant, median progression-free survival was significantly improved with VR-CAP (24.7 vs R-CHOP 14.4 months; P<0.001). This post-hoc analysis evaluated the association between the improved outcomes and quality of responses achieved with VR-CAP versus R-CHOP in LYM-3002. Patients were randomized to 6-8 21-day cycles of VR-CAP or R-CHOP...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28154092/increased-peroxisome-proliferator-activated-receptor-gamma-activity-reduces-imatinib-uptake-and-efficacy-in-chronic-myeloid-leukemia-mononuclear-cells
#12
Jueqiong Wang, Liu Lu, Chung H Kok, Verity A Saunders, Jarrad M Goyne, Phuong Dang, Tamara M Leclercq, Timothy P Hughes, Deborah L White
Imatinib is actively transported by OCT-1 influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia blood mononuclear cells is significantly associated with poor molecular response to imatinib. Here we report that, in diagnostic chronic myeloid leukemia mononuclear cells and BCR-ABL1+ cell lines, peroxisome proliferator-activated receptor gamma agonists (GW1929, rosiglitazone, pioglitazone) significantly decrease OCT-1 activity; conversely, peroxisome proliferator-activated receptor gamma antagonists (GW9662, T0070907) increase OCT-1 activity...
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154091/infection-as-a-cause-of-childhood-leukemia-virus-detection-employing-whole-genome-sequencing
#13
Christoph Bartenhagen, Ute Fischer, Klaus Korn, Stefan M Pfister, Michael Gombert, Cai Chen, Vera Okpanyi, Julia Hauer, Anna Rinaldi, Jean-Pierre Bourquin, Cornelia Eckert, Jianda Hu, Armin Ensser, Martin Dugas, Arndt Borkhardt
No abstract text is available yet for this article.
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154090/repeated-fecal-microbiota-transplantations-attenuate-diarrhea-and-lead-to-sustained-changes-in-the-fecal-microbiota-in-acute-refractory-gastrointestinal-graft-versus-host-disease
#14
Walter Spindelboeck, Eduard Schulz, Barbara Uhl, Karl Kashofer, Ariane Aigelsreiter, Wilma Zinke-Cerwenka, Adnan Mulabecirovic, Patrizia K Kump, Bettina Halwachs, Gregor Gorkiewicz, Heinz Sill, Hildegard Greinix, Christoph Högenauer, Peter Neumeister
No abstract text is available yet for this article.
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154089/genetic-polymorphism-at-bcl2-as-a-predictor-for-r-chop-efficacy-in-patients-with-diffuse-large-b-cell-lymphoma
#15
Morteza Bashash, Joseph M Connors, Randy D Gascoyne, Barbara Meissner, Johanna M Schuetz, Stephen Leach, Graham W Slack, Brian R Berry, Howard Hu, Laurie H Sehn, Angela R Brooks-Wilson, John J Spinelli
No abstract text is available yet for this article.
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154088/a-concise-revised-myeloma-comorbidity-index-as-a-valid-prognostic-instrument-in-a-large-cohort-of-801-multiple-myeloma-patients
#16
Monika Engelhardt, Anne-Saskia Domm, Sandra Maria Dold, Gabriele Ihorst, Heike Reinhardt, Alexander Zober, Stefanie Hieke, Corine Baayen, Stefan Jürgen Müller, Hermann Einsele, Pieter Sonneveld, Ola Landgren, Martin Schumacher, Ralph Wäsch
With growing numbers of elderly multiple myeloma patients, reliable tools to assess their vulnerability are required. The objective of this analysis was to develop and validate an easy to use myeloma-risk-score (revised Myeloma Comorbidity Index) that allows risk prediction of OS and PFS differences in a large patient cohort. We conducted a geriatric assessment in 801 consecutive myeloma patients, including comorbidity risks obtained at diagnosis. The cohort was examined within a training and validation set...
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154087/suppression-of-runx1-eto-oncogenic-activity-by-a-small-molecule-inhibitor-of-tetramerization
#17
Julia Schanda, Chun-Wei Lee, Katharina Wohlan, Uta Müller-Kuller, Hana Kunkel, Isabell Quagliano-Lo Coco, Stefan Stein, Alexander Metz, Joachim Koch, Jörn Lausen, Uwe Platzbecker, Hind Medyouf, Holger Gohlke, Michael Heuser, Matthias Eder, Manuel Grez, Michaela Scherr, Christian Wichmann
No abstract text is available yet for this article.
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154086/hyper-cvad-epratuzumab-as-salvage-regimen-for-younger-patients-with-relapsed-refractory-cd22-precursor-b-cell-all
#18
Patrice Chevallier, Sylvain Chantepie, Francoise Huguet, Emmanuel Raffoux, Xavier Thomas, Thibaut Leguay, Tony Marchand, Francoise Isnard, Aude Charbonnier, Sébastien Maury, Maria-Pilar Gallego-Hernanz, Nelly Robillard, Thierry Guillaume, Pierre Peterlin, Alice Garnier, Fanny Rialland, Claire Le Houerou, David M Goldenberg, William A Wegener, Marie-C Béné, Hervé Dombret
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February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154085/loss-of-foxm1-promotes-erythropoiesis-through-increased-proliferation-of-erythroid-progenitors
#19
Minyoung Youn, Nan Wang, Corinne LaVasseur, Elena Bibikova, Sharon Kam, Bertil Glader, Kathleen M Sakamoto, Anupama Narla
FOXM1 belongs to the fork head/winged-helix family of transcription factors and regulates a network of proliferation-associated genes. Its abnormal upregulation has been shown to be a key driver of cancer progression and an initiating factor in oncogenesis. FOXM1 is also highly expressed in stem/progenitor cells and inhibits their differentiation, suggesting that FOXM1 plays a role in the maintenance of multipotency. However, the exact molecular mechanisms by which FOXM1 regulates human stem/progenitor cells are still uncharacterized...
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28154084/lymphocyte-activation-gene-3-a-novel-therapeutic-target-in-chronic-lymphocytic-leukemia
#20
Mika Shapiro, Yair Herishanu, Ben-Zion Katz, Nili Dezorella, Clare Sun, Sigi Kay, Aaron Polliack, Irit Avivi, Adrian Wiestner, Chava Perry
A novel therapeutic approach in cancer, attempting to stimulate host anti-tumor immunity, involves blocking of immune checkpoints. LAG3 is an immune checkpoint receptor expressed on activated/exhausted T-cells. When engaged by MHC class II molecules, LAG3 negatively regulates T-cell function thereby contributing to tumor escape. Intriguingly, a soluble LAG3 variant activates both immune and malignant MHC class II-presenting cells. In this study, we examined the role of LAG3 in the pathogenesis of chronic lymphocytic leukemia, an MHC class II-presenting malignancy, and show that chronic lymphocytic leukemia cells express and secrete LAG3...
February 2, 2017: Haematologica
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