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Nancy M Heddle, Richard J Cook, Yang Liu, Michelle Zeller, Rebecca Barty, Jason P Acker, John Eikelboom, Donald M Arnold
BACKGROUND: There is recent support for long-term adverse effects of donor-recipient sex-mismatched red blood cell (RBC) transfusion, but short-term impact is unknown. A retrospective exploratory analysis was performed using data from a research database. METHODS: Adults admitted to hospitals in one Canadian center who received RBCs (2008-2014 [3 sites]; 2012-2014 [1 site]) were eligible. Patient data were extracted from a research database and donor data from the blood supplier...
November 10, 2018: Transfusion
Dennis Goldfinger, James D Burner
No abstract text is available yet for this article.
November 10, 2018: Transfusion
John G Boyle
No abstract text is available yet for this article.
November 9, 2018: Transfusion
Jansen N Seheult, Michelle N Stram, Jason Sperry, Philip C Spinella, Darrell J Triulzi, Mark H Yazer
BACKGROUND: There are multiple approaches to the blood product and fluid resuscitation of a bleeding trauma patient. An in silico model of different trauma resuscitation strategies was constructed to predict their effects on the volumes of the different body fluid compartments and on several important hemostatic factors. STUDY DESIGN AND METHODS: This multicompartment dynamic deterministic model comprised four interconnected modules (hemostatic, resuscitation, body fluid compartment, and dilutional coagulopathy)...
November 9, 2018: Transfusion
Wim de Kort, Femmeke Prinsze, Glenn Nuboer, Jos Twisk, Eva-Maria Merz
BACKGROUND: Both donors and the blood bank rely on the result of the donor health interview. However, survey data suggest that substantial variability in deferral rates among interviewers exist. We studied whether variability remained after adjusting for conditional factors. STUDY DESIGN AND METHODS: The data set included Dutch interview data on whole blood donor visits in 2015, where one of their visits was selected randomly. We applied logistic regression and multilevel regression analyses with the donor visit, with the interviewer representing the levels...
November 9, 2018: Transfusion
Christina L Dean, Cheryl L Maier, John D Roback, Sean R Stowell
BACKGROUND: Hemolytic transfusion reactions are a rare, yet serious complication of red blood cell (RBC) transfusion. Patients with sickle cell disease (SCD) are at an increased risk for such reactions, because they are prone to make alloantibodies against transfused RBCs, complicating this integral part of their disease management. These reactions may be missed, and the patient's state may be attributed to vaso-occlusive crisis (VOC), with misguided therapy ensuing. CASE REPORT: Herein, we report the clinical course of a patient with complex SCD with a delayed hemolytic transfusion reaction, followed by multiple acute hemolytic transfusion reactions mistaken for severe VOC...
November 9, 2018: Transfusion
Marion C Lanteri, Tamir Kanias, Sheila Keating, Mars Stone, Yuelong Guo, Grier P Page, Donald J Brambilla, Stacy M Endres-Dighe, Alan E Mast, Walter Bialkowski, Pam D'Andrea, Ritchard G Cable, Bryan R Spencer, Darrell J Triulzi, Edward L Murphy, Steven Kleinman, Mark T Gladwin, Michael P Busch
BACKGROUND: Genetic determinants may underlie the susceptibility of red blood cells (RBCs) to hemolyze in vivo and during routine storage. This study characterized the reproducibility and dynamics of in vitro hemolysis variables from a subset of the 13,403 blood donors enrolled in the RBC-Omics study. STUDY DESIGN AND METHODS: RBC-Omics donors with either low or high hemolysis results on 4°C-stored leukoreduced (LR)-RBC samples from enrollment donations stored for 39 to 42 days were recalled 2 to 12 months later to donate LR-RBCs...
November 8, 2018: Transfusion
Ruchika Goel, Debra Kessler, Vijay Nandi, Caroline Ortiz, Christopher D Hillyer, Beth H Shaz
BACKGROUND: Blood centers may offer point-based reward systems or cardiovascular disease (CVD) screening to incentivize donors. However, combining these incentives to improve CVD risk and blood donation rates has not been studied. STUDY DESIGN AND METHODS: Study was a three-arm prospective controlled trial: Group 1, control (routine points, no CVD screening); Group 2, CVD screening with routine points; and Group 3, CVD screening plus incentive double points. The primary objective was to determine if double versus routine incentive points led to improvement or maintenance of CVD risk profile assessed using self-reported changes in 1) reading food labels for calorie and fat content, 2) exercising daily, 3) reduced fat intake, and 4) increase in eating fruits and vegetables...
November 8, 2018: Transfusion
Lene Russell, Lars Broksø Holst, Theis Lange, Xuan Liang, Sisse Rye Ostrowski, Anders Perner
BACKGROUND: The effects of anemia and red blood cell (RBC) transfusion on markers of clot formation and platelet function in patients with septic shock are unknown. We assessed these effects in a randomized transfusion trial of patients with septic shock. STUDY DESIGN AND METHODS: We performed a prospective substudy of the Transfusion Requirements in Septic Shock (TRISS) trial, randomly assigning patients in the intensive care unit with septic shock and hemoglobin concentration of 9...
November 5, 2018: Transfusion
Sofiane Tariket, Jose A Guerrero, Olivier Garraud, Cedric Ghevaert, Fabrice Cognasse
BACKGROUND: Beyond their role in hemostasis and thrombosis, platelets are also important mediators of inflammation by the release of hundreds of factors stored in their α-granules. Mutations in Nbeal2 cause gray platelet syndrome (GPS), characterized by the lack of platelet α-granules. This study aims to evaluate the immunological (proinflammatory) effects of platelet α-granules. STUDY DESIGN AND METHODS: We performed an experiment using Nbeal2-/- mice, the mouse model of GPS...
November 5, 2018: Transfusion
Kit Lund, Maria Larsen, Eva Haastrup, Berit Pedersen, Lisa Maroun, Morten Andersen, Ole Bjerrum, Anne Fischer-Nielsen
BACKGROUND: Chronic myeloid leukemia (CML) is rarely diagnosed in pregnant women. CASE REPORT: We report a case of a pregnant woman who presented with a leukocyte count of 250 × 109 cells/L at gestational age (GA) 26 weeks and was diagnosed with CML in the chronic phase. Because the patient deliberately opted out of interferon α and tyrosine kinase inhibitor treatment, the main goal was to reduce the leukocyte count to postpone delivery beyond the number of weeks considered severely premature and avoid thromboembolic complications while continuously evaluating the clinical safety of the mother and fetus...
November 5, 2018: Transfusion
Tanja Netelenbos, Edwin Massey, Liesbeth C de Wreede, Kay Harding, Angela Hamblin, Mallika Sekhar, Anna Li, Paula F Ypma, Lynn Ball, Jaap Jan Zwaginga, Simon J Stanworth
BACKGROUND: Patients with prolonged neutropenia caused by chemotherapy or underlying marrow disorders are at risk of invasive bacterial and fungal infections. New treatment options alongside targeted antimicrobial therapy that might improve outcomes include granulocyte transfusions (GTX). To inform the research agenda, a prospective observational cohort study was performed in the Netherlands and United Kingdom. The aim was to describe the incidence, characteristics, and outcomes of patients developing invasive infections and assess patients fulfilling criteria for GTX...
November 1, 2018: Transfusion
Matthew A Warner, Ryan D Frank, Timothy J Weister, Mark M Smith, James R Stubbs, Daryl J Kor
BACKGROUND: Intraoperative plasma transfusion is common, yet little is known regarding its effects on perioperative coagulation tests or clinical outcomes. STUDY DESIGN AND METHODS: This is a retrospective cohort study of adults receiving intraoperative plasma transfusion at a single center from 2011 to 2015. Relationships between plasma transfusion volume, changes in coagulation test values, and clinical outcomes, including a primary outcome of early postoperative red blood cell (RBC) transfusion, were assessed with multivariable regression analyses...
November 1, 2018: Transfusion
Fernando A Fierro, Nataly Magner, Julie Beegle, Heather Dahlenburg, Jeannine Logan White, Ping Zhou, Karen Pepper, Brian Fury, Dane Philip Coleal-Bergum, Gerhard Bauer, William Gruenloh, Geralyn Annett, Christy Pifer, Jan A Nolta
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can actively seek out areas of low oxygen and secrete proangiogenic factors. In more severe trauma and chronic cases, however, cells alone may not be enough. Therefore, we have combined the stem cell and angiogenic factor approaches to make a more potent therapy. We developed an engineered stem cell therapy product designed to treat critical limb ischemia that could also be used in trauma-induced scarring and fibrosis where additional collateral blood flow is needed following damage to and blockage of the primary vessels...
November 1, 2018: Transfusion
Jae Hoon Lee, Jeonghyun Park, Jae-Woo Lee
Acute respiratory distress syndrome is a major cause of respiratory failure in critically ill patients. Despite extensive research into its pathophysiology, mortality remains high. No effective pharmacotherapy exists. Based largely on numerous preclinical animal studies, administration of mesenchymal stem or stromal cell (MSC) as a therapeutic for acute lung injury (ALI) holds great promise, and Phase I and II clinical trials are currently under way internationally. However, concern for the use of stem cells, specifically the risk of iatrogenic tumor formation, as well as the prohibitive cost of production, storage, and distribution of cells in bone marrow transplant facilities, may limit access to this lifesaving therapy...
November 1, 2018: Transfusion
Kevin P Blaine, Irene Cortés-Puch, Junfeng Sun, Dong Wang, Steven B Solomon, Jing Feng, Mark T Gladwin, Daniel B Kim-Shapiro, Swati Basu, Andreas Perlegas, Kamille West, Harvey G Klein, Charles Natanson
BACKGROUND: Storage temperature is a critical factor for maintaining red-blood cell (RBC) viability, especially during prolonged cold storage. The target range of 1 to 6°C was established decades ago and may no longer be optimal for current blood-banking practices. STUDY DESIGN AND METHODS: Human and canine RBCs were collected under standard conditions and stored in precision-controlled refrigerators at 2°C, 4°C, or 6°C. RESULTS: During 42-day storage, human and canine RBCs showed progressive increases in supernatant non-transferrin-bound iron, cell-free hemoglobin, base deficit, and lactate levels that were overall greater at 6°C and 4°C than at 2°C...
November 1, 2018: Transfusion
Karin van den Berg, Ronel Swanevelder, Charlotte Ingram, Denise Lawrie, Deborah Kim Glencross, Caroline Hilton, Martin Nieuwoudt
BACKGROUND: Several studies in developed countries have demonstrated high levels of iron deficiency (ID) among blood donors. There is a paucity of data for developing countries where blood shortages remain a major concern. STUDY DESIGN AND METHODS: A total of 4412 donors were enrolled in the study. Specimens were collected for full blood count, iron, transferrin saturation, and ferritin assessment. Donor demographics were recorded. ID was indicated by a ferritin level of less than 20 ng/mL for men and less than 12 ng/mL for women...
November 1, 2018: Transfusion
Katerina Pavenski, Sarah E Ward, Gregory M T Hare, John Freedman, Robisa Pulendrarajah, Razak A Pirani, Nicholas Sheppard, Colm Vance, Alexander White, Nick Lo, James P Waddell, Alex Ho, Emil H Schemitsch, Mark Kataoka, Earl R Bogoch, Kiran Saini, C David Mazer, James E Baker
BACKGROUND: Tranexamic acid (TXA) therapy is effective in reducing postoperative red blood cell (RBC) transfusion in total joint arthroplasty (TJA), yet uncertainty persists regarding comparative efficacy and safety among specific patient subgroups. We assessed the impact of a universal TXA protocol on RBC transfusion, postoperative hemoglobin (Hb), and adverse outcomes to determine whether TXA is safe and effective in TJA, both overall and in clinically relevant subgroups. STUDY DESIGN AND METHODS: A retrospective observational study was performed on patients undergoing TJA at our institution spanning 1 year before and after the implementation of a universal protocol to administer intravenous (IV) TXA...
November 1, 2018: Transfusion
Laura A Huppert, Kathleen D Liu, Michael A Matthay
No abstract text is available yet for this article.
November 1, 2018: Transfusion
Shigeharu Uchida, Masahiro Satake, Akemi Kurisu, Aya Sugiyama, Ko Ko, Tomoyuki Akita, Junko Tanaka
BACKGROUND: The classification of many new cases of hepatitis virus infection as overt hepatitis does not reflect the true incidence of infection because the disease takes an asymptomatic course in some cases. In this retrospective cohort study, we aimed to estimate the incidence rates of new hepatitis C virus (HCV) infections among the blood donors. STUDY DESIGN AND METHOD: A 5-year retrospective cohort study was conducted to estimate the incidence rates by using the medical records of the blood donors between 2008 and 2013 for HCV infection...
October 30, 2018: Transfusion
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