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Bryan R Spencer, Walter Bialkowski, Darryl V Creel, Ritchard G Cable, Joseph E Kiss, Mars Stone, Christopher McClure, Steven Kleinman, Simone A Glynn, Alan E Mast
BACKGROUND: High school students 16 to 18 years-old contribute 10% of the US blood supply. Mitigating iron depletion in these donors is important because they continue to undergo physical and neurocognitive development. STUDY DESIGN AND METHODS: Study objectives were to determine the prevalence of iron depletion in 16- to 18-year-old donors and whether their risk for iron depletion was greater than adult donors. Successful, age-eligible donors were enrolled from high school blood drives at two large US blood centers...
January 11, 2019: Transfusion
Sheila F O'Brien, Lori Osmond, Wenli Fan, Qi-Long Yi, Mindy Goldman
BACKGROUND: The deferral for men who have sex with men (MSM) was reduced from a permanent deferral for MSM if even one time since 1977 to progressively shorter time deferrals of 5 years and 1 year in Canada. We assessed compliance with these deferrals and the impact on safety at Canadian Blood Services. STUDY DESIGN AND METHODS: Three anonymous online compliance surveys of male whole blood donors were carried out before and after implementation of successive changes...
January 10, 2019: Transfusion
Seema Kacker, Evan M Bloch, Paul M Ness, Eric A Gehrie, Christi E Marshall, Parvez M Lokhandwala, Aaron A R Tobian
BACKGROUND: Bacterial contamination of platelets remains the leading infectious risk from blood transfusion. Pathogen reduction (PR), point-of-release testing (PORt), and secondary bacterial culture (SBC) have been proposed as alternative risk control strategies, but a comprehensive financial comparison has not been conducted. STUDY DESIGN AND METHODS: A Markov-based decision tree was constructed to model the financial and clinical impact of PR, PORt, and SBC, as well as a baseline strategy involving routine testing only...
January 8, 2019: Transfusion
Orzińska Agnieszka, Guz Katarzyna, Mikula Michal, Kluska Anna, Balabas Aneta, Ostrowski Jerzy, Uhrynowska Małgorzata, Kopeć Izabella, Dębska Marzena, Luterek Katarzyna, Brojer Ewa
BACKGROUND: Fetuses whose mothers have produced antibodies to red blood cell (RBC) or platelet antigens are at risk of being affected by hemolytic disease or alloimmune thrombocytopenia, respectively, only if they inherit the incompatible antigen. Noninvasive diagnosis of the fetal antigen is employed for management of immunized pregnancies, but the specific detection of SNPs, encoding the majority of antigens, in maternal plasma is still a challenge. We applied targeted next-generation sequencing (NGS) to predict the fetal antigen based on the detection of fetomaternal chimerism...
January 8, 2019: Transfusion
Caitlin McOmish
No abstract text is available yet for this article.
January 8, 2019: Transfusion
Melissa M Cushing, Robert A DeSimone, Ruchika Goel, Yen-Michael S Hsu, Priscilla Parra, Sabrina E Racine-Brzostek, Diana Degtyaryova, Dian T Lo, Meta Morrison, Kathleen M Crowley, Adrianna Rossi, Ljiljana V Vasovic
BACKGROUND: Daratumumab (DARA) is a human IgG1κ monoclonal antibody directed against CD38, approved for the treatment of multiple myeloma. As CD38 is expressed on RBCs, DARA can interfere with pretransfusion testing. DARA interference can be negated by denaturation of CD38 on RBCs with dithiothreitol (DTT) reagents. Because of this interference in pretransfusion testing, our hospital implemented a notification and testing/transfusion algorithm (NATTA) for pretransfusion testing and RBC product provision for DARA patients...
January 8, 2019: Transfusion
Peter Watson-Brown, Elvina Viennet, Gina Mincham, Craig R Williams, Cassie C Jansen, Brian L Montgomery, Robert L P Flower, Helen M Faddy
BACKGROUND: Zika virus (ZIKV) is transfusion-transmissible. In Australia the primary vector, Aedes aegypti, is established in the north-east, such that local transmission is possible following importation of an index case, which has the potential to impact on blood transfusion safety and public health. We estimated the basic reproduction number (R 0 ) to model the epidemic potential of ZIKV in Australian locations, compared this with the ecologically similar dengue viruses (DENV), and examined possible implications for blood transfusion safety...
January 8, 2019: Transfusion
Man Zhao, Qianqian Zhou, Chulin He, Yulong Zhang, Zhengjun Wang, Ruiying Cai, Cong Ma, Yuan Li, Xiaohui Wang, Linsheng Zhan
BACKGROUND: A complex array of physicochemical changes occurs in red blood cells (RBCs) during storage, leading to enhanced posttransfusion clearance. Dendritic cells (DCs) play crucial roles in the engulfment of aged RBCs; however, it is unclear how stored RBCs (sRBCs) modulate their responses to inflammatory stimuli and DC migration ability. STUDY DESIGN AND METHODS: In this study, we examined whether sRBCs affect the migration ability of DCs and elucidated the detailed mechanisms mediating this process...
January 7, 2019: Transfusion
Susan L Stramer, Jean Stanley, Megan L Nguyen, Rasa Bertuzis, Nancy Huynh, John R Duncan, Patrick Albrecht, Lisa L Pate, Susan A Galel
BACKGROUND: Chikungunya (CHIKV) and dengue (DENV) viruses are primarily mosquito-borne, but transfusion transmission can occur (DENV) or is likely (CHIKV). In the absence of commercially available blood screening assays, a variety of strategies to ensure recipient safety in the face of expanding CHIKV and/or DENV outbreaks have been used. STUDY DESIGN AND METHODS: Performance of cobas CHIKV/DENV, a qualitative RNA detection assay for use on the cobas 6800/8800 Systems, was evaluated at two sites (Roche Molecular Systems, Inc...
January 4, 2019: Transfusion
Adrianus J de Vries, Wytze J Vermeijden, L Joost van Pelt, Edwin R van den Heuvel, Willem van Oeveren
BACKGROUND: Several authors and manufacturers of cell salvage devices recommend additional filtering of processed blood before transfusion. There is no evidence to support this practice. Therefore, we compared the clinical outcome and biochemical effects of cell salvage with or without additional filtering. STUDY DESIGN AND METHODS: The patients, scheduled for coronary artery bypass grafting, valve replacement, or combined procedures were part of our randomized multicenter factorial study of cell salvage and filter use on transfusion requirements (ISRCTN 58333401)...
January 4, 2019: Transfusion
Eva N Glassou, Nickolaj Kristensen, Bjarne K Møller, Christian Erikstrup, Torben B Hansen, Alma B Pedersen
BACKGROUND: Do prescription drugs with anti-inflammatory properties such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and statins increase the risk of postoperative bleeding measured with RBC transfusion in elderly hip fracture surgery patients? STUDY DESIGN AND METHODS: Using the Danish Multidisciplinary Hip Fracture Database, 74,791 patients aged 65 years or older with surgery-treated hip fracture were identified during 2005-2016, and their use of NSAIDs, corticosteroids, and statins was ascertained...
January 4, 2019: Transfusion
Nora Doberschuetz, Jan Soerensen, Halvard Bonig, Andre Willasch, Eva Rettinger, Verena Pfirrmann, Emilia Salzmann-Manrique, Richard Schäfer, Thomas Klingebiel, Peter Bader, Andrea Jarisch
BACKGROUND: Autologous stem cell transplantation remains an integral treatment tool for certain childhood malignancies. In children, a central venous catheter is typically necessary to provide adequate flow rates for preparative apheresis. In this study, the feasibility and efficiency of collecting CD34+ cells via an indwelling Hickman catheter, preimplanted for chemotherapy, instead of placing an additional temporary central venous catheter was evaluated. STUDY DESIGN AND METHODS: Forty-eight pediatric leukaphereses for autologous hematopoietic stem cell transplantation using Spectra Optia MNC, Version 3...
January 4, 2019: Transfusion
Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Mahtab Atashibarg, Masood Haghshenas
BACKGROUND: Platelet storage is often complicated by deleterious changes that are started by reversible activation of the cells and can lead to procoagulant function and apoptosis during longer periods of storage. Given that increasing levels of reactive oxygen species (ROS) generation are associated with platelet activation and apoptosis, our study investigated whether ROS scavenging or the inhibition of ROS production can enhance the viability of stored platelets. METHODS: For this study platelet-rich plasma platelet concentrates (PRP-PCs) were either treated with ROS-reducing agents (1 mM N-acetyl-L -cysteine [NAC] or 30 μM NADPH oxidase [NOX] inhibitor, VAS2870) or kept untreated during storage...
January 4, 2019: Transfusion
Asunción Mora, Luis Ayala, Rafael Bielza, F Ataúlfo González, Ana Villegas
BACKGROUND: One of the medical areas where errors can have more serious consequences is the process of blood transfusion. We used failure mode and effect analysis (FMEA) for evaluating potential failures and improving transfusion safety in a medium-size urban hospital with a highly complex transfusion service. STUDY DESIGN AND METHODS: Each failure mode was evaluated using the likelihood of occurrence, severity of the effect, and probability of detection. The obtained results allowed each failure to be prioritized and decisions to be made in an organized manner to determine solutions...
January 4, 2019: Transfusion
Mindy Goldman, Marc Germain, Yves Grégoire, Ralph R Vassallo, Hany Kamel, Marjorie Bravo, David O Irving, Emanuele Di Angelantonio, Whitney R Steele, Sheila F O'Brien
BACKGROUND: Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries. STUDY DESIGN AND METHODS: Twelve blood center members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative from four countries with no upper age limit for whole blood and double RBC donation (Canada, New Zealand, England, and the United States) or an upper age limit of 80 (Australia) provided 2016 data on donors and donations, deferral rates, and vasovagal reactions by donor age and sex...
January 4, 2019: Transfusion
Nicolas Burin des Roziers, Philippe Chadebech, Lucile Malard, Benoit Vingert, Philippe Gallon, Didier Samuel, Rachid Djoudi, Anne-Marie Fillet, France Pirenne
BACKGROUND: Recent reports have indicated that the risk of anti-D alloimmunization following D-incompatible platelet (PLT) transfusion is low in hematology and oncology patients. We investigated the rate of anti-D alloimmunization in RhD-negative (D- ) patients with chronic liver disease transfused with D+ platelet concentrates (PCs) and the factors involved, at a liver transplant (LT) center. STUDY DESIGN AND METHODS: We reviewed the blood bank database from January 2003 to October 2016...
January 3, 2019: Transfusion
Dana V Foss, Megan L Hochstrasser, Ross C Wilson
Clustered regularly interspaced short palindromic repeats (CRISPR)-driven genome editing has rapidly transformed preclinical biomedical research by eliminating the underlying genetic basis of many diseases in model systems and facilitating the study of disease etiology. Translation to the clinic is under way, with announced or impending clinical trials utilizing ex vivo strategies for anticancer immunotherapy or correction of hemoglobinopathies. These exciting applications represent just a fraction of what is theoretically possible for this emerging technology, but many technical hurdles must be overcome before CRISPR-based genome editing technology can reach its full potential...
January 2, 2019: Transfusion
Margit Boshuizen, Maike E van Hezel, Lisa van Manen, Marleen Straat, Yvemarie B O Somsen, Angelique M E Spoelstra-de Man, Neil Blumberg, Robin van Bruggen, Nicole P Juffermans
BACKGROUND: Anemia of inflammation (AI) has a high prevalence in critically ill patients. In AI, iron metabolism is altered, as high levels of inflammation-induced hepcidin reduce the amount of iron available for erythropoiesis. AI is treated with red blood cell (RBC) transfusions. The effect of RBC transfusion on iron metabolism during inflammatory processes in adults is unknown. We investigated the effect of RBC transfusion on iron metabolism in critically ill patients. METHODS: In a prospective cohort study in 61 critically ill patients who received 1 RBC unit, levels of iron variables were determined before, directly after, and 24 hours after transfusion in septic and nonseptic patients...
December 31, 2018: Transfusion
Linn Stenfelt, Julia S Westman, Åsa Hellberg, Martin L Olsson
BACKGROUND: The P1 antigen was first described in 1927 and belongs to the P1PK histo-blood group system, together with Pk and NOR. The A4GALT-encoded 4-α-galactosyltransferase synthesizes these antigens and has been considered to extend glycolipids exclusively. However, contradicting studies have been published regarding the presence of P1 on human glycoproteins. In other species, P1 occurs on glycoproteins. Furthermore, human ABH antigens occur on both glycolipids and glycoproteins and are biochemically related to P1...
December 30, 2018: Transfusion
Ravi M Patel, Cassandra D Josephson, Neeta Shenvi, Akhil Maheshwari, Kirk A Easley, Sean Stowell, Martha Sola-Visner, Francisca Ferrer-Marin
BACKGROUND: Prior studies have suggested an association between platelet transfusions (PTXs) and worse outcomes among infants with necrotizing enterocolitis (NEC), potentially mediated by proinflammatory factors released by platelets. However, the effects of storage on platelet proinflammatory factor release and the confounding role of illness severity on NEC outcomes have not been determined. STUDY DESIGN AND METHODS: First, neuropeptide Y (a potent splanchnic vasoconstrictor released by platelets) was measured by enzyme-linked immunosorbent assay in fresh frozen plasma and in the supernatant of leukoreduced apheresis-derived platelets at different times during storage...
December 30, 2018: Transfusion
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