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Transfusion

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https://www.readbyqxmd.com/read/29341199/timing-of-gamma-irradiation-and-blood-donor-sex-influences-in-vitro-characteristics-of-red-blood-cells
#1
Dirk de Korte, Louis Thibault, Wiebke Handke, Sarah K Harm, Alex Morrison, Aine Fitzpatrick, Denese C Marks, Qi-Long Yi, Jason P Acker
BACKGROUND: There are few studies investigating the effect of irradiation on red blood cells (RBCs) during storage. This study analyzed changes in in vitro quality of RBCs irradiated at several points during storage with the aim of providing evidence to support current maximum pre- and postirradiation storage limits. STUDY DESIGN AND METHODS: Each of seven participating centers produced four pools of 7 standard RBC units (SAGM, AS-3, or PAGGSM), which were then split back into 7 units...
January 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29332317/routine-use-of-day%C3%A2-6-and-day%C3%A2-7-platelets-with-rapid-testing-two-hospitals-assess-impact-1%C3%A2-year-after-implementation
#2
Sarah K Harm, Zbigniew M Szczepiorkowski, Nancy M Dunbar
BACKGROUND: In March 2016 the US Food and Drug Administration published a draft guidance to enhance the safety of platelets (PLTs) for transfusion. Options for hospital transfusion services include the use of rapid testing to extend apheresis PLT dating for up to 7 days. This report describes the impact of routine use of Day 6 and Day 7 PLTs at two hospital transfusion services 1 year after implementation of rapid testing for outdate extension. STUDY DESIGN AND METHODS: PLT transfusion and inventory data were obtained from two hospital-based transfusion services for 12 months before and 12 months after implementation of rapid testing to extend the outdate of apheresis PLTs to 7 days...
January 14, 2018: Transfusion
https://www.readbyqxmd.com/read/29332316/how-do-i-implement-a-whole-blood-program-for-massively-bleeding-patients
#3
Mark H Yazer, Andrew P Cap, Philip C Spinella, Louis Alarcon, Darrell J Triulzi
Building on the successful military experience, interest has been rekindled in transfusing whole blood (WB) early in the resuscitation of traumatically injured civilians, often before their ABO group is known. WB efficiently provides treatment for shock and coagulopathy, as well as platelet hemostatic function, to patients losing large volumes of blood. Unlike group O uncrossmatched red blood cells (RBCs), group O WB contains a substantial amount of plasma, which is incompatible with the RBCs of all non-group O recipients...
January 14, 2018: Transfusion
https://www.readbyqxmd.com/read/29330877/characterization-of-biologic-response-modifiers-in-the-supernatant-of-conventional-refrigerated-and-cryopreserved-platelets
#4
Lacey Johnson, Shereen Tan, Emily Jenkins, Ben Wood, Denese C Marks
BACKGROUND: Alternatives to room temperature storage of platelets (PLTs) are of interest to support blood banking logistics. The aim of this study was to compare the presence of biologic response modifiers (BRMs) in PLT concentrates stored under conventional room temperature conditions with refrigerated or cryopreserved PLTs. STUDY DESIGN AND METHODS: A three-arm pool-and-split study was carried out using buffy coat-derived PLTs stored in 30% plasma/70% SSP+. The three matched treatment arms were as follows: room temperature (20-24°C), cold (2-6°C), and cryopreserved (-80°C with DMSO)...
January 12, 2018: Transfusion
https://www.readbyqxmd.com/read/29322525/zika-virus-rna-polymerase-chain-reaction-on-the-utility-channel-of-a-commercial-nucleic-acid-testing-system
#5
Mohamed Boujnan, Ashley J Duits, Marco H G M Koppelman
BACKGROUND: Several countries have implemented safety strategies to reduce the risk of Zika virus (ZIKV) transmission through blood transfusion. These strategies have included nucleic acid amplification testing (NAT) of blood donations. In this study, a new real-time polymerase chain reaction (PCR) assay including internal control for the detection of ZIKV on the cobas omni Utility Channel (UC) on the cobas 6800 system is presented. STUDY DESIGN AND METHODS: PCR conditions and primer/probe concentrations were optimized on the LightCycler 480 instrument...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29322519/inactivation-of-chikungunya-virus-in-blood-components-treated-with-amotosalen-ultraviolet-a-light-or-amustaline-glutathione
#6
Andrew Laughhunn, Yan-Jang S Huang, Dana L Vanlandingham, Marion C Lanteri, Adonis Stassinopoulos
BACKGROUND: Chikungunya virus, a mosquito-borne arbovirus, often co-circulates with the Zika, dengue, and yellow fever viruses in Aedes mosquito-infested areas where cases of arbovirus transfusion-transmitted infections have been reported. Building on past experience to help maintain the availability of safe components during major outbreaks of chikungunya virus in La Reunion, Italy, and Thailand and of Zika virus in the Pacific, the Caribbean, and the Americas, pathogen inactivation is a mitigation strategy to reduce the risk of transfusion-transmitted infection...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29322517/discordant-human-t-lymphotropic-virus-screening-with-western-blot-confirmation-evaluation-of-the-dual-test-algorithm-for-us-blood-donations
#7
Susan L Stramer, Rebecca L Townsend, Gregory A Foster, Ramona Johnson, Barbara Weixlmann, Roger Y Dodd
BACKGROUND: Human T-lymphotropic virus (HTLV) blood donation screening has used a dual-testing algorithm beginning with either a chemiluminescent immunoassay or enzyme-linked immunosorbent screening assay (ELISA). Before the availability of a licensed HTLV supplemental assay, repeat-reactive (RR) samples on a first assay (Assay 1) were retested with a second screening assay (Assay 2). Donors with RR results by Assay 2 were deferred from blood donation and further tested using an unlicensed supplemental test to confirm reactivity while nonreactive (NR) donors remained eligible for donation until RR on a subsequent donation...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29322515/current-practices-in-perioperative-blood-management-for-patients-undergoing-liver-resection-a-survey-of-surgeons-and-anesthesiologists
#8
Sean Bennett, Abdul Ayoub, Alexandre Tran, Shane English, Alan Tinmouth, Daniel I McIsaac, Dean Fergusson, Guillaume Martel
BACKGROUND: Development of intraoperative techniques and blood management strategies in liver resection, and the multidisciplinary nature of perioperative transfusion decision making, creates an opportunity for practice variation. The aim of this study was to describe the current practices in perioperative blood management and explore differences between surgeons and anesthesiologists. STUDY DESIGN AND METHODS: A Web-based survey was developed, piloted, and circulated to Canadian liver surgeons and anesthesiologists...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29315670/identification-of-novel-variant-b-alleles-within-the-abo-gene
#9
Yunlei He, Gang Deng, Deyi Xu, Lu Yu, Wenyu Guo
No abstract text is available yet for this article.
January 7, 2018: Transfusion
https://www.readbyqxmd.com/read/29315627/transfusion-support-for-transgender-men-of-childbearing-age
#10
James A Mays, Dina N Greene, Ryan A Metcalf, Monica B Pagano
BACKGROUND: To date, limited attention has been given to transgender recipients of blood components, particularly transgender men of childbearing age. Here, we highlight the essential information needed to provide transfusion support for this population. CASE REPORT: A 40-year-old transgender man, who retained his uterus and ovaries, presented with severe vaginal hemorrhage following biopsies for a cervical mass. He was admitted to the Gynecology unit and emergency blood was ordered...
January 7, 2018: Transfusion
https://www.readbyqxmd.com/read/29315622/patient-rescue-and-blood-utilization-in-the-ogasawara-blood-rotation-system
#11
Tomoko Igarashi, Hiroshi Fujita, Hiroyuki Asaka, Yuko Takada, Rieko Ametani, Itsuki Naya, Yasushi Tanaka, Makoto Kamesaki, Asuka Kasai
BACKGROUND: In the past, blood products were not transported to the Ogasawara Islands because of the distance; the islands are approximately 1000 km from the mainland and lack an airport. The Ogasawara Blood Rotation system involves the routine, long-distance transportation of Type O, RhD-positive, irradiated red blood cells to rescue patients with acute hemorrhage and severe anemia and to reduce wastage from the expiration of red blood cell solution. STUDY DESIGN AND METHODS: Blood transfusion and utilization in the Ogasawara blood rotation (BR) system were examined from December 2014 to March 2017...
January 7, 2018: Transfusion
https://www.readbyqxmd.com/read/29282743/mitochondrial-dna-multiplex-real-time-polymerase-chain-reaction-inhibition-assay-for-quality-control-of-pathogen-inactivation-by-ultraviolet-c-light-in-platelet-concentrates
#12
Sinyoung Kim, Wiebke Handke, Ute Gravemann, Andrea Döscher, Veronika Brixner, Thomas H Müller, Axel Seltsam
BACKGROUND: Several ultraviolet (UV) light-based pathogen inactivation (PI) technologies for platelet (PLT) products have been developed or are under development. Upon implementation of PI technologies, quality control measures are required to ensure consistent efficiency of the treatment process. Previous reports showed that amotosalen/UVA and riboflavin/UV-based PI technologies induce modifications of the PLT-derived mitochondrial DNA (mtDNA) that can be detected by polymerase chain reaction (PCR) inhibition assays...
December 28, 2017: Transfusion
https://www.readbyqxmd.com/read/29282742/evaluation-of-the-impact-of-a-personalized-postdonation-short-messaging-service-on-the-retention-of-whole-blood-donors
#13
Carley N Gemelli, Alison Carver, Alana Garn, Stephen T Wright, Tanya E Davison
BACKGROUND: Short messaging service (SMS) is routinely used by blood collection agencies to remind donors about appointments but has been applied less frequently in interventions to increase return behavior. This study aimed to investigate whether receipt of a personalized postdonation SMS promoted donor retention. STUDY DESIGN AND METHODS: A postdonation SMS was sent to 2605 whole blood donors who had donated at one of six donor centers in Australia from April to July 2015 and left without making a forward appointment...
December 28, 2017: Transfusion
https://www.readbyqxmd.com/read/29277913/unrelated-donor-choices-for-allogeneic-hematopoietic-cell-transplantation-in-canada-an-evaluation-of-factors-influencing-donor-selection
#14
Valerie Greco-Stewart, Jeffrey Kiernan, Donna Killeen, Sherry Haun, Dena Mercer, Kimberly Young, Robert S Liwski, David S Allan
BACKGROUND: Utilization of unrelated donors and cord blood units (CBUs) for allogeneic hematopoietic cell transplantation continues to increase. Understanding the practices of donor selection by transplant centers is critical for unrelated donor registries and cord blood banks to optimize registry composition and inventory to meet patient need. STUDY DESIGN AND METHODS: Unrelated donor and CBU selection practices of Canadian transplant centers served by Canadian Blood Services' OneMatch Stem Cell & Marrow Network (OM) were reviewed, including HLA match level, locus of disparity, age, sex, and product choice (donor vs...
December 25, 2017: Transfusion
https://www.readbyqxmd.com/read/29277910/associated-factors-of-umbilical-cord-blood-collection-quality
#15
REVIEW
Lionel Faivre, Chloé Couzin, Hélène Boucher, Thomas Domet, André Desproges, Olivier Sibony, Marina Bechard, Valérie Vanneaux, Jérôme Larghero, Audrey Cras
After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta...
December 25, 2017: Transfusion
https://www.readbyqxmd.com/read/29266289/a-novel-nucleotide-deletion-in-rhag-allele-identified-in-a-chinese-rhnull-individual
#16
Li Tian, Hong Xu, Jie Xiao, Binwu Ying
No abstract text is available yet for this article.
December 21, 2017: Transfusion
https://www.readbyqxmd.com/read/29266284/eligibility-and-willingness-to-donate-blood-in-men-who-have-had-sex-with-men
#17
Bas Romeijn, Eva-Maria Merz, Gerjo Kok, Wim de Kort, Anne van Dongen
BACKGROUND: Several countries have changed, or are reevaluating, their blood donor policies for men who have had sex with men (MSM). Changing policies has consequences for donor recruitment and the donor pool. In this study, we investigated whether MSM are eligible and willing to donate blood. STUDY DESIGN AND METHODS: Members of a research panel (n = 4422) in the Netherlands were invited to participate in an online survey. We asked questions about male-to-male sex and risk behavior that are also asked during the predonation screening of a blood donor...
December 21, 2017: Transfusion
https://www.readbyqxmd.com/read/29266276/evaluation-of-the-advantages-of-platelet-concentrates-stored-at-4%C3%A2-c-versus-22%C3%A2-c
#18
Jiangcun Yang, Wen Yin, Yali Zhang, Yang Sun, Ting Ma, Shunli Gu, Ying Gao, Xiaole Zhang, Jun Yuan, Wenhua Wang
BACKGROUND: Platelet (PLT) storage at cold temperatures (4°C) can reduce bacterial contamination and lower the risk of transfusion-related complications. We compared the effects of 22 and 4°C storage conditions for PLTs to further explore the efficiency of hemostasis in acute bleeding and extended PLT shelf life. STUDY DESIGN AND METHODS: Manually prepared PLTs (PLT concentrates in plasma, not PLT additive solution) were stored at 4 and 22°C. The PLT counts, scanning electronic microscope observations, blood gas indices, biochemical indices, PLT aggregative function, and surface CD62P expression were monitored and compared between the groups...
December 21, 2017: Transfusion
https://www.readbyqxmd.com/read/29266261/patients-and-health-care-professionals-perceptions-of-blood-transfusion-a-systematic-review
#19
REVIEW
Brittannia Abdul-Aziz, Fabiana Lorencatto, Simon J Stanworth, Jill J Francis
BACKGROUND: Blood transfusions are frequently prescribed for acute and chronic conditions; however, the extent to which patients' and health care professionals' (HCPs') perceptions of transfusion have been investigated is unclear. Patients' treatment perceptions influence how patients cope with illnesses or symptoms. HCPs' perceptions may influence treatment decision making. STUDY DESIGN AND METHODS: This was a systematic review of studies post-1984 reporting adult patients' and HCPs' perceptions of blood transfusion...
December 19, 2017: Transfusion
https://www.readbyqxmd.com/read/29250797/short-term-effect-of-preoperative-intravenous-iron-therapy-in-colorectal-cancer-patients-with-anemia-results-of-a-cohort-study
#20
Michael Jordi Wilson, Jan Willem Dekker, Emma Bruns, Wernard Borstlap, Johannes Jeekel, Jaap Jan Zwaginga, Martin Schipperus
BACKGROUND: In the treatment of preoperative anemia, which is associated with increased postoperative morbidity, iron supplementation can replace blood transfusion and erythropoiesis-stimulating agents. The aim of this study was to assess the efficacy of preoperative intravenous (IV) iron infusion in optimizing hemoglobin (Hb) levels in anemic colorectal cancer patients. STUDY DESIGN AND METHODS: A retrospective cohort study was performed on patients who underwent surgery for colorectal cancer between 2010 and 2016 in a single teaching hospital...
December 17, 2017: Transfusion
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