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Transfusion

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https://www.readbyqxmd.com/read/29148053/effective-inactivation-of-a-wide-range-of-viruses-by-pasteurization
#1
Albrecht Gröner, Connie Broumis, Randel Fang, Thomas Nowak, Birgit Popp, Wolfram Schäfer, Nathan J Roth
BACKGROUND: Careful selection and testing of plasma reduces the risk of blood-borne viruses in the starting material for plasma-derived products. Furthermore, effective measures such as pasteurization at 60°C for 10 hours have been implemented in the manufacturing process of therapeutic plasma proteins such as human albumin, coagulation factors, immunoglobulins, and enzyme inhibitors to inactivate blood-borne viruses of concern. A comprehensive compilation of the virus reduction capacity of pasteurization is presented including the effect of stabilizers used to protect the therapeutic protein from modifications during heat treatment...
November 16, 2017: Transfusion
https://www.readbyqxmd.com/read/29134668/factors-affecting-patient-reported-outcomes-after-red-blood-cell-transfusion-in-medical-patients
#2
Ka Lok Luke Chan, Wai Man Vivien Mak, Yat Hung Tam, Kwok Kuen Harold Lee
BACKGROUND: Physical variables like mortality or cardiac events were used to evaluate the requirement of red blood cell (RBC) transfusion. However, patient-reported outcomes (PROs) of blood transfusion recipients were seldom assessed. The health-related quality of life (HRQoL) of patients before and after RBC transfusion was compared in this study. STUDY DESIGN AND METHODS: The study period was February to June 2016. Standardized generic and anemia symptom-specific HRQoL instruments were administered to patients receiving RBC transfusion in the medical unit of a single center...
November 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29134662/dose-capping-of-plerixafor-in-patients-weighing%C3%A2-more-than-100%C3%A2-kg-at-one-vial-led-to-successful-mobilization-outcomes-and-significant-cost-savings
#3
Gabriel Park, Sepideh Shayani, Tracey Stiller, Shirong Wang, Shan Yuan
BACKGROUND: Plerixafor is frequently used as an adjunct agent to improve mobilization of peripheral blood stem cells in many clinical settings. However, its high cost (>$8000 per single-use 24-mg vial) is a significant concern. The manufacturer-recommended dose is 0.24 mg/kg. Therefore, patients weighing more than 100 kg would require a second vial, thus doubling the drug cost per dose. We implemented a policy of capping the dose of plerixafor at 24 mg, or one vial, for patients weighing more than 100 kg...
November 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29134658/-best-practice-for-extracorporeal-photopheresis-in-acute-and-chronic-graft-versus-host-disease-by-societa-italiana-di-emaferesi-and-manipolazione-cellulare-and-gruppo-italiano-trapianto-midollo-osseo-a-national-survey-to-ascertain-its-degree-of-application
#4
Luca Pierelli, Alberto Bosi, Attilio Olivieri
BACKGROUND: A recent "best practice" promoted and published by Gruppo Italiano Trapianto Midollo Osseo (GITMO) and Societa' Italiana di Emaferesi and Manipolazione Cellulare (SIDEM) on the use of extracorporeal photopheresis (ECP) in acute and chronic graft-versus-host disease (GVHD) has been tested for the degree of agreement and application among Italian transplant centers. STUDY DESIGN AND METHODS: Twenty-four Italian centers coordinating a pair number of transplant programs completed the Web-based survey within the fixed deadline, representing approximately 52% of those centers that have a GITMO-accredited allogeneic transplant program that routinely uses ECP in GVHD...
November 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29119575/occurrence-of-hemolytic-reactions-on-the-same-day-as-immune-globulin-product-administrations-during-2008-to-2014
#5
Gayathri Sridhar, Bola F Ekezue, Hector S Izurieta, Richard A Forshee, Nandini Selvam, Paul D Mintz, Steven A Anderson, Mikhail D Menis
BACKGROUND: Hemolytic reactions (HRs) are rare serious adverse events after immune globulin (IG) use. Our large claims-based study evaluated occurrence of same-day hemolysis after administration of different IG products and potential risk factors, during the 2008 to 2014 study period. STUDY DESIGN AND METHODS: We conducted a retrospective cohort study using a large commercial administrative database. The study included individuals exposed to IG products as identified by procedure codes...
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29119573/temperature-cycling-during-platelet-cold-storage-improves-in-vivo-recovery-and-survival-in-healthy-volunteers
#6
Jaroslav G Vostal, Monique P Gelderman, Andrey Skripchenko, Fei Xu, Ying Li, Johannah Ryan, Chunrong Cheng, Pam Whitley, Michael Wellington, Sherrie Sawyer, Shalene Hanley, Stephen J Wagner
BACKGROUND: Room temperature (RT) storage of platelets (PLTs) can support bacterial proliferation in contaminated units, which can lead to transfusion-transmitted septic reactions. Cold temperature storage of PLTs could reduce bacterial proliferation but cold exposure produces activation-like changes in PLTs and leads to their rapid clearance from circulation. Cold-induced changes are reversible by warming and periodic rewarming during cold storage (temperature cycling [TC]) has been proposed to alleviate cold-induced reduction in PLT circulation...
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29119571/targeted-exome-sequencing-defines-novel-and-rare-variants-in-complex-blood-group-serology-cases-for-a-red-blood-cell-reference-laboratory-setting
#7
Elizna M Schoeman, Eileen V Roulis, Yew-Wah Liew, Jacqueline R Martin, Tanya Powley, Brett Wilson, Glenda M Millard, Eunike C McGowan, Genghis H Lopez, Helen O'Brien, Jennifer A Condon, Robert L Flower, Catherine A Hyland
BACKGROUND: We previously demonstrated that targeted exome sequencing accurately defined blood group genotypes for reference panel samples characterized by serology and single-nucleotide polymorphism (SNP) genotyping. Here we investigate the application of this approach to resolve problematic serology and SNP-typing cases. STUDY DESIGN AND METHODS: The TruSight One sequencing panel and MiSeq platform was used for sequencing. CLC Genomics Workbench software was used for data analysis of the blood group genes implicated in the serology and SNP-typing problem...
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29119567/identification-of-a-novel-missense-mutation-in-a-allele-in-a-chinese-individual
#8
Yujie Kong, Xue Tian, Zhong Liu, Li Tian
No abstract text is available yet for this article.
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29119564/intracranial-hemorrhages-in-neonates-born-from-32-weeks-of-gestation-low-frequency-of-associated-fetal-and-neonatal-alloimmune-thrombocytopenia-a-register-based-study
#9
Erle Refsum, Stellan Håkansson, Anette Mörtberg, Agneta Wikman, Magnus Westgren
BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition, with an estimated incidence of one in 1000 to 2000 live births. Predominantly, FNAIT is due to maternal alloantibodies that target paternally derived human platelet antigen (HPA) 1a. The most feared complication is an intracranial hemorrhage (ICH). The aim of this study was to determine the frequency of associated maternal platelet (PLT) alloimmunization in a population of neonates born from 32 weeks of gestation and diagnosed with an ICH...
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29106732/a-systematic-review-of-incentives-in-blood-donation
#10
Kathleen Chell, Tanya E Davison, Barbara Masser, Kyle Jensen
BACKGROUND: Incentives are often used to enhance the effectiveness of recruitment and retention campaigns targeting blood donors. However, the degree to which incentives succeed in attracting and facilitating repeat donation is unclear. A systematic literature review, following PRISMA guidelines, investigated the existing empirical evidence regarding the use of monetary and nonmonetary incentives within blood donation. STUDY DESIGN AND METHODS: A comprehensive search of relevant databases identified a total of 71 papers for inclusion in the review for defining and operationalizing incentives (Objective 1), of which nine papers empirically investigated attitudes toward incentives (Objective 2), 31 papers investigated the impact on blood donation behavior (Objective 3), and eight papers investigated the impact on blood safety (Objective 4)...
November 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29106709/a-new-genetic-background-for-the-jr-a-blood-group-phenotype-caused-by-the-abcg2-439t-allele-encoding-a-p-arg147trp-change
#11
Carola Wieckhusen, Gabi Rink, Erwin A Scharberg, Sina Rothenberger, Annette Stürtzel, Ekkehard Richter, Peter Bugert
No abstract text is available yet for this article.
November 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29106707/c-518t%C3%A2-%C3%A2-c-missense-mutation-in-the-b-glycosyltransferase-gene-responsible-for-a-weak-b-variant
#12
Yanling Ying, Xiaozhen Hong, Shu Chen, Ji He, Faming Zhu
No abstract text is available yet for this article.
November 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29106698/preoperative-screening-and-intervention-for-mild-anemia-with-low-iron-stores-in-elective-hip-and-knee-arthroplasty
#13
Andrea Pujol-Nicolas, Rory Morrison, Clare Casson, Sameer Khan, Allan Marriott, Christopher Tiplady, Alwyn Kotze, William Gray, Mike Reed
BACKGROUND: Preoperative anemia in patients undergoing elective hip and knee arthroplasty is associated with increased postoperative morbidity and mortality, red blood cell (RBC) transfusion, and length of stay (LOS). The aim of this study was to assess the effect of optimizing hemoglobin (Hb) levels before elective primary hip and knee arthroplasty. STUDY DESIGN AND METHODS: This is a prospective comparative cohort study of patients who underwent elective hip and knee arthroplasty before (control) and after (intervention) the launch of a Hb optimization program...
November 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29090466/age-of-platelet-concentrates-and-time-to-the-next-transfusion
#14
Camila Caram-Deelder, Johanna G van der Bom, Hein Putter, Anja Leyte, Daan van de Kerkhof, Dorothea Evers, Erik A Beckers, Floor Weerkamp, Francisca Hudig, Jaap Jan Zwaginga, Jan M M Rondeel, Karen M K de Vooght, Nathalie C V Péquériaux, Otto Visser, Jonathan P Wallis, Rutger A Middelburg
BACKGROUND: Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim of this study was to quantify the association between storage time of PLT concentrates and interval to the next PLT transfusion for different types of PLT components, stored for up to 7 days and transfused to transfusion-dependent hematooncology patients with thrombocytopenia. STUDY DESIGN AND METHODS: From a cohort of patients from 10 major Dutch hospitals, patients were selected whose transfusion patterns were compatible with PLT transfusion dependency due to hematooncologic disease...
October 31, 2017: Transfusion
https://www.readbyqxmd.com/read/29076173/fear-of-donation-related-stimuli-is-reported-across-different-levels-of-donation-experience
#15
Christopher R France, Janis L France
BACKGROUND: This study aimed to characterize the extent of donation-related fears among donors with different levels of donation experience. STUDY DESIGN AND METHODS: A sample of 1054 recent donors (48.3% female; mean ± SD age 33.1 ± 9.8 years) completed an anonymous, online survey of their fear of donation-related stimuli, including blood, needles, pain, and fainting. Respondents also provided information regarding demographics, pain, and vasovagal symptoms associated with their recent donation and confidence and intention with respect to a future donation...
October 26, 2017: Transfusion
https://www.readbyqxmd.com/read/29076164/nonhemolytic-passenger-lymphocyte-syndrome
#16
S Gerald Sandler, Suhua Han, Albert Langeberg, Cal Matsumoto, Thomas M Fishbein
BACKGROUND: An 8-month-old recipient of a liver segment transplant had anti-D detected for the first time in her Day 5 posttransplant plasma and anti-C detected for the first time in her Day 55 posttransplant plasma. The donor's plasma contained anti-C and anti-D. Clinical and laboratory findings established a diagnosis of passenger lymphocyte syndrome (PLS). Hemolysis did not occur, because the recipient's blood group phenotype was, by chance, D- C-. STUDY DESIGN AND METHODS: To evaluate contemporary practice for diagnosing PLS, we conducted a retrospective 10-year literature review...
October 26, 2017: Transfusion
https://www.readbyqxmd.com/read/29076161/use-of-the-blood-substitute-hboc-201-in-critically-ill-patients-during-sickle-crisis-a-three-case-series
#17
Jonathan M Davis, Nura El-Haj, Nimish N Shah, Garry Schwartz, Margaret Block, James Wall, Mark Tidswell, Ernest DiNino
BACKGROUND: Red blood cell (RBC) transfusion is an important treatment modality during severe sickle cell crisis (SCC). SCC patients who refuse, or cannot accept, RBCs present a unique challenge. Acellular hemoglobin (Hb)-based oxygen carriers (HBOCs) might be an alternative for critically ill patients in SCC with multiorgan failure due to life-threatening anemia. HBOC-201 (HbO2 Therapeutics) has been administered to more than 800 anemic patients in 22 clinical trials, but use of any HBOCs in critically ill sickle cell patients with organ failure is exceedingly rare...
October 26, 2017: Transfusion
https://www.readbyqxmd.com/read/29067705/demographic-and-epidemiologic-characterization-of-transfusion-recipients-from-four-us-regions-evidence-from-the-reds-iii-recipient-database
#18
Matthew S Karafin, Roberta Bruhn, Matt Westlake, Marian T Sullivan, Walter Bialkowski, Gustaf Edgren, Nareg H Roubinian, Ronald G Hauser, Daryl J Kor, Debra Fleischmann, Jerome L Gottschall, Edward L Murphy, Darrell J Triulzi
BACKGROUND: Blood transfusion is one of the most common medical procedures during hospitalization in the United States. To understand the benefits of transfusion while mitigating potential risks, a multicenter database containing detailed information on transfusion incidence and recipient outcomes would facilitate research. STUDY DESIGN AND METHODS: The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) program has developed a comprehensive transfusion recipient database utilizing data from hospital electronic health records at 12 participating hospitals in four geographic regions...
October 24, 2017: Transfusion
https://www.readbyqxmd.com/read/29063631/donor-specific-individuality-of-red-blood-cell-performance-during-storage-is-partly-a-function-of-serum-uric-acid-levels
#19
Vassilis L Tzounakas, Dimitrios G Karadimas, Alkmini T Anastasiadi, Hara T Georgatzakou, Eleftheria Kazepidou, Dimitris Moschovas, Athanassios D Velentzas, Anastasios G Kriebardis, Nikolaos E Zafeiropoulos, Apostolos Avgeropoulos, Marilena Lekka, Konstantinos E Stamoulis, Issidora S Papassideri, Marianna H Antonelou
BACKGROUND: Previous investigations in leukoreduced units of red blood cells (RBCs) in mannitol additive solution revealed the close association of uric acid (UA) levels in vivo with the susceptibility of RBCs to storage lesion markers. In this study, we examined whether UA has a similar correlation with the capability of RBCs to cope with the oxidative provocations of storage under different conditions, namely, in CPDA-1 and in the absence of leukoreduction. STUDY DESIGN AND METHODS: The UA-dependent antioxidant capacity of the supernatant was measured in nonleukoreduced units of RBCs in CPDA (n = 47)...
October 23, 2017: Transfusion
https://www.readbyqxmd.com/read/29052223/identification-of-four-novel-rhd-alleles-by-weakened-antigen-d-expression
#20
Helene Polin, Melanie Brisner, Anna Reiter, Martin Danzer
No abstract text is available yet for this article.
October 20, 2017: Transfusion
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