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Transfusion

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https://www.readbyqxmd.com/read/28084008/pulsed-xenon-flash-treatment-inactivates-bacteria-in-apheresis-platelet-concentrates-while-preserving-in-vitro-quality-and-functionality
#1
Hideki Abe, Masayuki Shiba, Yoshiyuki Niibe, Kenji Tadokoro, Masahiro Satake
BACKGROUND: Pulsed xenon (Xe) flash without any photoreactive compounds has been shown to inactivate a type of bacteria spiked into platelet (PLT) suspension in plasma, but enhanced the PLT storage lesion (PSL). Predicting reduction of PSL with increasing bactericidal ability, pulsed Xe flash was filtered through a band-stop filter, which excluded ultraviolet (UV)A, UVB, and visible light. STUDY DESIGN AND METHODS: Apheresis PLT concentrates (PCs) inoculated with bacteria were irradiated with filtered Xe flash (fXe treatment)...
January 12, 2017: Transfusion
https://www.readbyqxmd.com/read/28083954/donating-blood-on-a-regular-basis-appears-to-reduce-blood-pressure-but-appearances-can-be-deceiving
#2
Christopher R France, Janis L France, Lina K Himawan, Debra A Kessler, Mark Rebosa, Beth H Shaz
BACKGROUND: Previous studies have reported a relationship between blood donation and decreased risk for cardiovascular events, and it has been proposed that this may be due to a lowering of blood pressure among hypertensive individuals who donate on a regular basis. STUDY DESIGN AND METHODS: With the use of a retrospective longitudinal analysis, predonation blood pressure readings were examined across consecutive whole blood donations for New York Blood Center donors...
January 12, 2017: Transfusion
https://www.readbyqxmd.com/read/28083876/dynamic-changes-in-absolute-immature-platelet-count-suggest-the-presence-of-a-coexisting-immune-process-in-the-setting-of-thrombotic-thrombocytopenic-purpura
#3
Catherine M Stefaniuk, Hollie M Reeves, Robert W Maitta
BACKGROUND: Previous studies have indicated the usefulness of absolute immature platelet counts (A-IPCs) in the management and diagnostic algorithm of thrombotic thrombocytopenic purpura (TTP). Specifically a threefold increase in A-IPC from baseline may be diagnostic of TTP. Here, A-IPC was used to understand a coexisting immune dysregulation complicating TTP treatment. CASE REPORT: A 17-year-old previously healthy female was admitted with altered mental status, petechiae, anemia, thrombocytopenia, and schistocytes on peripheral smear...
January 12, 2017: Transfusion
https://www.readbyqxmd.com/read/28035775/reducing-liberal-red-blood-cell-transfusions-at-an-academic-medical-center
#4
Harry S Saag, Claudette M Lajam, Simon Jones, Nikita Lakomkin, Joseph A Bosco, Rebecca Wallack, Spiros G Frangos, Prashant Sinha, Nicole Adler, Patti Ursomanno, Leora I Horwitz, Frank M Volpicelli
BACKGROUND: Educational and computerized interventions have been shown to reduce red blood cell (RBC) transfusion rates, yet controversy remains surrounding the optimal strategy needed to achieve sustained reductions in liberal transfusions. STUDY DESIGN AND METHODS: The purpose of this study was to assess the impact of clinician decision support (CDS) along with targeted education on liberal RBC utilization to four high-utilizing service lines compared with no education to control service lines across an academic medical center...
December 30, 2016: Transfusion
https://www.readbyqxmd.com/read/28035774/prevalence-of-hepatitis-e-virus-infection-among-blood-donors-in-mainland-china-a-meta-analysis
#5
Longmu Zhang, Shuxian Jiao, Zhongsi Yang, Lei Xu, Li Liu, Qiuxia Feng, Xia Zhang, Yun Hou, Shuyi He, John Saldanha, Shuang Wang, Bin Wang
BACKGROUND: The risk of hepatitis E virus (HEV) infection from blood transfusion has raised increasing concern in many countries. Several transfusion-transmitted cases have been described in the United Kingdom and Japan. The objective was to investigate the prevalence of HEV infection among Chinese blood donors and analyze the potential risk of HEV infection through blood transfusion in China. STUDY DESIGN AND METHODS: Major English and Chinese research databases were used as background research for the study of locations, years, and the number of HEV infections among blood donors in China...
December 30, 2016: Transfusion
https://www.readbyqxmd.com/read/28035773/additional-intraarticular-tranexamic-acid-further-reduced-postoperative-blood-loss-compared-to-intravenous-and-topical-bathed-tranexamic-acid-in-total-hip-arthroplasty-a-retrospective-sequential-series-study
#6
Nariaki Nakura, Kazuo Hirakawa, Satoshi Takayanagi, Akira Saito, Koji Tsuji, Yasunobu Tamaki, Shunsuke Ochiai, Masahiko Mihara
BACKGROUND: Topical tranexamic acid (TXA) administration has been described to be effective in decreasing blood loss in total hip arthroplasty (THA). The aim of this retrospective study was to evaluate whether topical intraarticular TXA administration in addition to intravenous (IV) and topical bathed TXA further reduces blood loss in THA patients. STUDY DESIGN AND METHODS: Four-hundred patients were enrolled in this sequential series study with two different phases during four different time periods...
December 30, 2016: Transfusion
https://www.readbyqxmd.com/read/28032635/dexamethasone-promotes-granulocyte-mobilization-by-prolonging-the-half-life-of-granulocyte-colony-stimulating-factor-in-healthy-donors-for-granulocyte-transfusions
#7
Ida H Hiemstra, John L van Hamme, Machiel H Janssen, Timo K van den Berg, Taco W Kuijpers
BACKGROUND: Granulocyte transfusion (GTX) is a potential approach to correcting neutropenia and relieving the increased risk of infection in patients who are refractory to antibiotics. To mobilize enough granulocytes for transfusion, healthy donors are premedicated with granulocyte-colony-stimulating factor (G-CSF) and dexamethasone. Granulocytes have a short circulatory half-life. Consequently, patients need to receive GTX every other day to keep circulating granulocyte counts at an acceptable level...
December 28, 2016: Transfusion
https://www.readbyqxmd.com/read/28019034/inactivation-of-zika-virus-by-solvent-detergent-treatment-of-human-plasma-and-other-plasma-derived-products-and-pasteurization-of-human-serum-albumin
#8
Denis Kühnel, Sebastian Müller, Alexander Pichotta, Kai Uwe Radomski, Andreas Volk, Torben Schmidt
BACKGROUND: In 2016 the World Health Organization declared the mosquito-borne Zika virus (ZIKV) a "public health emergency of international concern." ZIKV is a blood-borne pathogen, which therefore causes concerns regarding the safety of human plasma-derived products due to potential contamination of the blood supply. This study investigated the effectiveness of viral inactivation steps used during the routine manufacturing of various plasma-derived products to reduce ZIKV infectivity...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28019032/severe-cardiac-iron-toxicity-in-two-adults-with-sickle-cell-disease
#9
Hellen Oduor, Caterina P Minniti, Alessandra Brofferio, Ahmed M Gharib, Khaled Z Abd-Elmoniem, Matthew M Hsieh, John F Tisdale, Courtney D Fitzhugh
BACKGROUND: Use of chronic blood transfusions as a treatment modality in patients with blood disorders places them at risk for iron overload. Since patients with β-thalassemia major (TM) are transfusion-dependent, most studies on iron overload and chelation have been conducted in this population. While available data suggest that compared to TM, patients with sickle cell disease (SCD) have a lower risk of extrahepatic iron overload, significant iron overload can develop. Further, previous studies have demonstrated a direct relationship between iron overload and morbidity and mortality rates in SCD...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28019031/pathogen-inactivation-by-riboflavin-and-ultraviolet-light-illumination-accelerates-the-red-blood-cell-storage-lesion-and-promotes-eryptosis
#10
Syed M Qadri, Deborah Chen, Peter Schubert, Darian L Perruzza, Varsha Bhakta, Dana V Devine, William P Sheffield
BACKGROUND: Pathogen reduction treatment using riboflavin and ultraviolet light illumination (Mirasol) effectively reduces the risk of transfusion-transmitted infections. This treatment is currently licensed for only platelets and plasma products, while its application to whole blood (WB) to generate pathogen-inactivated red blood cells (RBCs) is under development. RBC storage lesion, constituting numerous morphologic and biochemical changes, influences RBC quality and limits shelf life...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28019030/histone-deacetylase-inhibitors-suppress-abo-transcription-in-vitro-leading-to-reduced-expression-of-the-antigens
#11
Yoichiro Takahashi, Rieko Kubo, Rie Sano, Tamiko Nakajima, Keiko Takahashi, Momoko Kobayashi, Hiroshi Handa, Junichi Tsukada, Yoshihiko Kominato
BACKGROUND: The ABO system is of fundamental importance in the fields of transfusion and transplantation and has apparent associations with certain diseases, including cardiovascular disorders. ABO expression is reduced in the late phase of erythroid differentiation in vitro, whereas histone deacetylase inhibitors (HDACIs) are known to promote cell differentiation. Therefore, whether or not HDACIs could reduce the amount of ABO transcripts and A or B antigens is an intriguing issue. STUDY DESIGN AND METHODS: Quantitative polymerase chain reactions were carried out for the ABO transcripts in erythroid-lineage K562 and epithelial-lineage KATOIII cells after incubation with HDACIs, such as sodium butyrate, panobinostat, vorinostat, and sodium valproate...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28019029/hla-drb3-01-01-is-a-predictor-of-immunization-against-human-platelet-antigen-1a-but-not-of-the-severity-of-fetal-and-neonatal-alloimmune-thrombocytopenia
#12
Sandra Wienzek-Lischka, Inke R König, Eva-Maria Papenkort, Holger Hackstein, Sentot Santoso, Ulrich J Sachs, Gregor Bein
BACKGROUND: Most cases of fetal and neonatal alloimmune thrombocytopenia (FNAIT) are caused by maternal alloantibodies against human platelet antigen-1a (HPA-1a). Alloimmunization mainly occurs in HPA-1a-negative mothers who are carriers of the HLA-DRB3*01:01 allele. Recently, it has been reported that the combined presence of HLA-DRB3*01:01 and HLA-DRB4*01:01P was associated with severity of FNAIT. We tested this hypothesis by analyzing a large cohort of cases and controls. STUDY DESIGN AND METHODS: In total, 101 mothers with a history of FNAIT caused by anti-HPA-1a were investigated...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28019012/improved-planning-of-leukapheresis-endpoint-with-customized-prediction-algorithm-minimizing-collection-days-volume-of-blood-processed-procedure-time-and-citrate-toxicity
#13
Daniel L Leberfinger, Kira L Badman, Joseph M Roig, Tamara Loos
BACKGROUND: Increased emphasis on cost and productivity in apheresis centers calls for a proficient and predictable hematopoietic progenitor cell (HPC) collection. Therefore, the aim of this study was to determine the value of a customized predictive algorithm that estimates how many blood volumes are required to process for a targeted CD34 cell dose. STUDY DESIGN AND METHODS: Retrospective analysis was performed on 107 HPC collections completed on the Spectra Optia MNC from January 2013 to June 2014 in 51 patients and 12 donors...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28019009/restrictive-versus-liberal-red-blood-cell-transfusion-strategy-after-hip-surgery-a-decision-model-analysis-of-healthcare-costs
#14
Mario V Fusaro, Nathan D Nielsen, Alexandra Nielsen, Magali J Fontaine, John R Hess, Robert M Reed, Sylvain DeLisle, Giora Netzer
BACKGROUND: Red blood cell transfusion related to select surgical procedures accounts for approximately 2.8 million transfusions in the United States yearly and occurs commonly after hip fracture surgeries. Randomized controlled trials have demonstrated lack of clinical benefit with higher versus lower transfusion thresholds in postoperative hip fracture repair patients with cardiac disease or risk factors for cardiac disease. The economic implications of a higher versus lower hemoglobin (Hb) threshold have not yet been investigated...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28019007/proposed-revised-nomenclature-for-transfusion-related-acute-lung-injury
#15
Pearl Toy, Steven H Kleinman, Mark R Looney
A decade ago, definitions of "transfusionߚrelated acute lung injury (TRALI)" and "possible TRALI" were standardized for research and clinical diagnosis. Since then, evidence has confirmed that TRALI is often due to transfusion of white blood cell antibodies to at-risk patients, and the term "TRALI, antibody mediated" is appropriate for such cases. Other TRALI cases are non-antibody mediated. Because specific, nonantibody transfusion factors have not yet been confirmed to cause TRALI in humans, the general term "TRALI, non-antibody mediated" is appropriate for such cases...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28000304/discriminating-the-hemolytic-risk-of-blood-type-a-plasmas-using-the-complement-hemolysis-using-human-erythrocytes-chuhe-assay
#16
Kenji M Cunnion, Pamela S Hair, Neel K Krishna, Megan A Sass, Clinton W Enos, Pamela H Whitley, Lanne Y Maes, Corinne L Goldberg
BACKGROUND: The agglutination-based cross-matching method is sensitive for antibody binding to red blood cells but is only partially predictive of complement-mediated hemolysis, which is important in many acute hemolytic transfusion reactions. Here, we describe complement hemolysis using human erythrocytes (CHUHE) assays that directly evaluate complement-mediated hemolysis between individual serum-plasma and red blood cell combinations. The CHUHE assay is used to evaluate correlations between agglutination titers and complement-mediated hemolysis as well as the hemolytic potential of plasma from type A blood donors...
December 20, 2016: Transfusion
https://www.readbyqxmd.com/read/27990642/anemia-tolerance-during-normo-hypo-and-hypervolemia
#17
Malte Krömker, Patrick Lauscher, Harry Kertscho, Kai Zacharowski, Peter Rosenberger, Jens Meier
BACKGROUND: Restrictive intraoperative fluid management has been demonstrated to improve outcome of visceral and lung surgery in several studies. However, subsequent hypovolemia (HOV) may be accompanied by a decrease of anemia tolerance, resulting in increased transfusion needs. We therefore investigated the effect of volume status on anemia tolerance. STUDY DESIGN AND METHODS: Eighteen domestic pigs of either sex (mean weight, 23.5 ± 4.8 kg) were anesthetized, ventilated, and randomized into three experimental groups: normovolemia (no intervention), HOV (blood loss of 40% of blood volume), and hypervolemia (HEV; volume infusion of 40% of blood volume)...
December 19, 2016: Transfusion
https://www.readbyqxmd.com/read/27987219/relative-efficacy-of-tranexamic-acid-and-preoperative-anemia-treatment-for-reducing-transfusions-in-total-joint-arthroplasty
#18
Joseph F Styron, Alison K Klika, Caleb R Szubski, Deborah Tolich, Wael K Barsoum, Carlos A Higuera
BACKGROUND: This study aimed to evaluate the efficacy of a perioperative blood management (PBM) protocol at a large, tertiary hospital at reducing blood transfusions after total hip or knee arthroplasty (THA or TKA). STUDY DESIGN AND METHODS: A retrospective review of the PBM for patients undergoing THA or TKA was performed. Adjusted multiple logistic and Poisson regression models examined the effect of patient characteristics and preoperative, intraoperative, and postoperative factors on the likelihood of transfusion and units transfused...
December 17, 2016: Transfusion
https://www.readbyqxmd.com/read/27987208/poor-stem-cell-harvest-may-not-always-be-related-to-poor-mobilization-lessons-gained-from-a-mobilization-study-in-patients-with-%C3%AE-thalassemia-major
#19
Varnavas C Constantinou, Asimina Bouinta, Garyfalia Karponi, Fani Zervou, Penelope-Georgia Papayanni, George Stamatoyannopoulos, Achilles Anagnostopoulos, Evangelia Yannaki
BACKGROUND: Hematopoietic stem cell mobilization and leukapheresis in adult patients with β-thalassemia have recently been optimized in the context of clinical trials for obtaining hematopoietic stem cells for thalassemia gene therapy. In some patients, however, the yield of cluster of differentiation 34-positive (CD34+) cells was poor despite successful mobilization, and a modification of apheresis settings was mandatory for harvest rescue. STUDY DESIGN AND METHODS: Data were analyzed from 20 adult patients with β-thalassemia who were enrolled in a clinical trial of optimizing mobilization strategies for stem cell gene therapy...
December 17, 2016: Transfusion
https://www.readbyqxmd.com/read/27987206/zika-virus-is-not-thermostable-very-effective-virus-inactivation-during-heat-treatment-pasteurization-of-human-serum-albumin
#20
Maria R Farcet, Thomas R Kreil
BACKGROUND: The ongoing Zika virus (ZIKV) outbreak in the Americas has also raised concerns around the potential for ZIKV transmission via blood products. Plasma-derived products are considered safe, because effective viral-inactivation and removal methods are implemented in their manufacturing processes. However, a recent study has indicated that ZIKV is "thermally stable" compared with the closely related Dengue virus, thus raising the question of whether heat treatments, as embedded in the manufacturing of plasma-derived products, are as effective against ZIKV as was previously shown for other Flaviviruses...
December 17, 2016: Transfusion
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