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Tohoku Journal of Experimental Medicine

Jin Qi, Yaoqi Yang, Ping Hao, Jianqiang Xu
We reported "Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression" in Tohoku J. Exp. Med., 2017, 241 (1), 55-63; doi: 10.1620/tjem.241.55. After publication of the paper, we have become aware of the ethical violation in collecting the samples from some patients. We therefore wish to retract the paper and apologize for any inconvenience caused by the retraction.
August 2017: Tohoku Journal of Experimental Medicine
Yuya Takakubo, Daichi Ohta, Masaji Ishi, Juji Ito, Hiroharu Oki, Yasushi Naganuma, Tomohiro Uno, Akiko Sasaki, Takeru Akabane, Katsuyuki Dairaku, Shinichi Goto, Yasuo Goto, Yumiko Kanauchi, Shinji Kobayashi, Taku Nakajima, Keiji Masuda, Michiharu Matsuda, Nariyuki Mura, Kenji Takenouchi, Hiroyuki Tsuchida, Yasushi Onuma, Junichirou Shibuya, Mitsuyoshi Seino, Osamu Yamaguchi, Ken Hiragami, Yasuhiro Urayama, Takashi Furukawa, Shouta Okuda, Ken Ogura, Takeshi Nakamura, Kan Sasaki, Tsuneo Konta, Michiaki Takagi
Atypical femoral fractures (AFFs) have been reported to occur with minimal or spontaneous subtrochanteric and femoral shaft fractures with a characteristic transverse pattern, compared with typical femoral fractures in young patients with high-energy trauma. AFFs are related to long-term use of bisphosphonates (BPs), glucocorticoids and rheumatic diseases. We have estimated a blind analysis of AFFs in rheumatic patients receiving BPs and glucocorticoids ordinary over a long time in all Yamagata prefectural area through radiographic examination...
August 2017: Tohoku Journal of Experimental Medicine
Inho Bang, Young-Jin Jeong, Young-Yoon Park, Na-Yeon Moon, Junyong Lee, Tae-Hee Jeon
In Korea, the prevalence of depression is increasing in adolescents and the most common cause of death of adolescents has been reported as suicide. At a time of increasing predicament of mental health of adolescents, there are few studies on whether secondhand smoking is associated with mental health in adolescents. The objective of this study was to determine whether exposure to secondhand smoke is associated with mental health-related variables, such as depression, stress, and suicide, in Korean adolescents...
August 2017: Tohoku Journal of Experimental Medicine
Takayuki Shiina, Gaku Saito, Takao Sakaizawa, Hiroyuki Agatsuma, Yoshiaki Tominaga, Akira Hyogotani, Kazutoshi Hamanaka, Masayuki Toishi, Keiichiro Takasuna, Ryoichi Kondo, Kazuo Yoshida, Ken-Ichi Ito
Thymidylate synthase (TS) is essential in thymidylate biosynthesis and DNA replication. Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme in pyrimidine catabolism and is important in catabolism of 5-fluorouracil (5-FU). The significance of TS and DPD expressed in lung cancer remains controversial. Here we analyzed the relationship between TS and DPD expression and clinicopathological features of lung cancer. Enzyme-linked immunosorbent assays (ELISAs) were used to measure TS and DPD levels in paired tumor and non-tumor lung tissues obtained from 168 patients (107 adenocarcinomas, 39 squamous cell carcinomas, and 22 others), who had operations at the Shinshu University Hospital from 2004 to 2007 and were followed up for a median of 57...
August 2017: Tohoku Journal of Experimental Medicine
Seon Ha Baek, Ran-Hui Cha, Shin Wook Kang, Cheol Whee Park, Dae Ryong Cha, Sung Gyun Kim, Sun Ae Yoon, Sejoong Kim, Sang Youb Han, Jung Hwan Park, Jae Hyun Chang, Chun Soo Lim, Yon Su Kim, Ki Young Na
Patients with chronic kidney disease (CKD) have markedly increased rates of major adverse cardiovascular and cerebrovascular events (MACCEs) and mortality. Therefore, identifying early biomarkers predicting clinical outcomes in patients with CKD is critical. We aimed to determine whether osteoglycin, a basic component of the vascular extracellular matrix, was associated with MACCEs or all-cause mortality, using data from a prospective randomized controlled study, K-STAR (Kremezin STudy Against Renal disease progression in Korea: NCT 00860431)...
August 2017: Tohoku Journal of Experimental Medicine
Nattakarn Nooron, Koji Ohba, Kazuhisa Takeda, Shigeki Shibahara, Anchalee Chiabchalard
Cholangiocarcinoma represents the second most common primary liver tumor after hepatocellular carcinoma. Mahanine, a carbazole alkaloid derived from Murraya koenigii (Linn.) Spreng, has been used as folk medicine in Thailand, where the liver fluke-associated cholangiocarcinoma is common. The expression of microphthalmia-associated transcription factor (MITF) is maintained at immunohistochemically undetectable levels in hepatocytes and cholangiocytes. To explore the regulation of MITF expression in the liver, we immunohistochemically analyzed the MITF expression using hepatocellular carcinoma and cholangiocarcinoma specimens of the human liver cancer tissue array...
August 2017: Tohoku Journal of Experimental Medicine
Jelena Tosic Dragovic, Jovan Popovic, Petar Djuric, Ana Bulatovic, Aleksandar Jankovic, Ivana Buzadzic, Nada Dimkovic
Cardiovascular morbidity is the leading cause of death in dialysis patients and many risk factors have been involved in its pathogenesis. Genetic susceptibility may be of importance including polymorphism for matrix metalloproteinase 3 (MMP3), which is an enzyme that catalyzes the degradation of collagen, proteoglycans, fibronectin, laminine and elastin. The MMP3 gene promoter contains an insertion/deletion polymorphism characterised by an array of 5 or 6 adenosine residues (5A/6A) at -1612 position. Literature data show that the 5A or 6A allele of the MMP3 gene shows different risk for cardiovascular and overall outcome in general population...
August 2017: Tohoku Journal of Experimental Medicine
Cai-Li Guo, Xiao-Min Sun, Xiao-Wen Wang, Qing Guo
Bronchial asthma (BA) is a chronic inflammatory disorder of airways for which the effective therapies include inhaled corticosteroids (ICS) and short-acting β2-adrenoreceptor agonist (SABA). Serum eosinophil cationic protein (ECP) has been reported to reflect the degree of airway inflammation. We, therefore, explored the implication of serum ECP in assessing the efficacy of ICS therapy in BA children. Our prospective randomized control study enrolled 126 BA children and 78 healthy children (the control group)...
August 2017: Tohoku Journal of Experimental Medicine
Keisuke Maeda, Hiroshi Shamoto, Satoshi Furuya
Japan was struck by two catastrophic disasters on March 11, 2011 and on April 16, 2016. The former was the Great East Japan Earthquake (M9.0) and the latter was the Kumamoto Earthquake (M7.0). Most inhabitants in the affected areas of both disasters were forced to live in evacuation centers right after the earthquake. Poor oral hygiene, inactivity, malnourishment, appetite loss, eating problems, and swallowing problems due to lack of support for frail, disabled, or elderly evacuees occur during the early phases after a disaster...
August 2017: Tohoku Journal of Experimental Medicine
Chaeyoon Cho, Changwan Han, Misun Sung, Chaewon Lee, Minji Kim, Yoshiko Ogawa, Masahiro Kohzuki
The effect of aerobic exercise on physical function and mental health in various adult age groups (young-old, 65-74; old-old, 75-84; oldest-old, ≥ 85 years) is unclear. The aim of this study was to investigate the effects of the Kohzuki Exercise Program (KEP) on physical function and mental health in these age groups. The KEP consisted of 40-min supervised sessions 3 times per week for 6 months as follows: 5 min of warm-up, 30 min of lower limb aerobic exercise, and 5 min of cool-down. A total of 50 participants (22 young-old, 20 old-old, and 8 oldest-old) who participated in the KEP completed at least 88% of the sessions...
August 2017: Tohoku Journal of Experimental Medicine
Hitoshi Kuroda, Kazuo Inoue, Shin Takayama, Tadashi Ishii
On March 11, 2011, a magnitude 9.0 earthquake and huge tsunami occurred near the Pacific coast of northeast Japan, in which more than 18,000 people died or went missing and more than 120,000 buildings were destroyed. In Taro district, one of the areas struck hardest by the tsunami, a middle-aged woman was found deceased in the rubble. Generally, a family physician can recognize victims based on their appearance; the place where they were found; their home or work address; their belongings; the identifying marks on their clothes; their dental charts; and their living biological parents, children, or multiple siblings through DNA analysis...
July 2017: Tohoku Journal of Experimental Medicine
Yukio Nakamura, Shigeharu Uchiyama, Mikio Kamimura, Shota Ikegami, Masatoshi Komatsu, Hiroyuki Kato
Osteoporosis is characterized by the systemic impairment of bone mass, strength, and microarchitecture, leading to an increased risk of fragility fracture. Bisphosphonates (BPs) are the first-line drugs for osteoporosis. Vitamin D is considered to be essential for osteoporotic treatment. However, long-term effects of BPs on the serum levels of 25-hydroxyvitamin D3 (25(OH)D3) are unknown. Accordingly, in this retrospective study, we collected clinical data of 41 post-menopausal Japanese women with osteoporosis treated with BP for over 3 years, without vitamin D supplementation...
July 2017: Tohoku Journal of Experimental Medicine
Takero Nakajima, Yang Yang, Yu Lu, Yuji Kamijo, Yosuke Yamada, Kozo Nakamura, Masahiro Koyama, Shohei Yamaguchi, Eiko Sugiyama, Naoki Tanaka, Toshifumi Aoyama
Insufficient intake of polyunsaturated fatty acids (PUFA) causes fatty liver. The mechanism responsible is primarily related to increased lipogenesis and decreased FA degradation based on rodent studies. However, these studies were limited by the fact that the typical PUFA-deficient diets contained insufficient amounts of long-chain FA, the PUFA-containing diets were primarily composed of n-3 PUFA-enriched oil, and the intake of PUFA was excessive compared with the physiological requirement. To address these issues, mice were fed a PUFA-deficient diet containing long-chain FA at a standard fed level and then were orally fed a n-3/n-6-balanced PUFA-containing oil [PUFA (+)] or a PUFA-deficient oil [PUFA (-)] at physiological relevant levels (0...
July 2017: Tohoku Journal of Experimental Medicine
Tamao Takahashi, Satoru Ebihara, Masahiro Kohzuki
Obesity is a major risk factor of cardiovascular, osteoarthritis, metabolic and pulmonary disorders, and exercise is an efficient method for treating obesity. However, obese patients often complain of dyspnea on exertion, which makes it difficult to continue exercise program. Obesity is also known to have an adverse effect on pulmonary function. The purpose of this study was to examine the effects of a comprehensive obesity rehabilitation (COR) program on pulmonary function in Japanese patients with morbid obesity...
July 2017: Tohoku Journal of Experimental Medicine
Junko Okuyama, Shunichi Funakoshi, Hiroaki Tomita, Takuhiro Yamaguchi, Hiroo Matsuoka
How natural disasters affect the psychological state of adolescents has not been well studied. Thus, we examined the effect of a natural disaster on high-school-aged youth and considered the most effective forms of support following such a disaster. We examined students from two high schools that were near the epicenter of the 9.0-magnitude Great East Japan Earthquake, which struck the Tohoku coastal area on March 11, 2011, causing severe damage to the region. The questionnaires measuring depression, anxiety, and post-traumatic stress reaction (PTSR) was administered to the students 3 times between July 2012 and August 2014; students who scored above the cut-off values of these measures were considered high-risk students...
July 2017: Tohoku Journal of Experimental Medicine
Tomowaki Nakagawa, Ko Hashimoto, Takumi Tsubakino, Takeshi Hoshikawa, Takashi Inawashiro, Yasuhisa Tanaka
Human lumbar spine usually consists of five vertebrae; however, some individuals have vertebral anomalies with four or six lumbar vertebrae because of sacralized fifth lumbar vertebra (L5 sacralization) or lumbarized first sacral vertebra (S1 lumbarization), respectively. These vertebral anomalies are called lumbosacral transitional vertebra (LSTV). Although LSTV is an asymptomatic anomaly, it is known to cause misconception in spinal counts and in spinal level at lumbar spinal surgery. The purpose of this study is to evaluate how LSTV affects the diagnosis and surgeries in lumbar spine disorders...
July 2017: Tohoku Journal of Experimental Medicine
Yoshihiro Hagiwara, Takuya Sekiguchi, Yumi Sugawara, Yutaka Yabe, Masashi Koide, Nobuyuki Itaya, Shinichiro Yoshida, Yasuhito Sogi, Masahiro Tsuchiya, Ichiro Tsuji, Eiji Itoi
The Great East Japan Earthquake (GEJE) and Tsunami devastated the northeastern coast of Japan on March 11, 2011. This study attempted to determine whether socio-psychological factors such as sleep disturbance and psychological distress influenced new-onset subjective shoulder pain in survivors, during the post disaster phase of the GEJE. From November 2012 to February 2013 (2 years after the GEJE) and November 2014 to January 2015 (4 years after the GEJE), survivors (18 years old or over) answered self-reported questionnaires...
July 2017: Tohoku Journal of Experimental Medicine
Akihito Usui, Yusuke Kawasumi, Kiyotaka Usui, Yuya Ishizuka, Kaito Takahashi, Masato Funayama, Haruo Saito
Traditional autopsy has changed little in the past century. In Japan, the rate of forensic autopsy in cases of unusual death is very low. Therefore, multi-slice computed tomography (CT) has been used to obtain imaging data instead of or in addition to autopsy in suspicious forensic cases. In our institute, postmortem multi-slice CT has been performed since 2009, and by 2014 there were over 1,000 cases. Our extensive experience with postmortem CT shows that in many cases of death by drug overdose, stomach contents exhibit high X-ray absorption...
July 2017: Tohoku Journal of Experimental Medicine
Xiaoyan Guo, Mingrui Lin, Tengfei Shi, Wei Yan, Wenxu Chen
Multiple osteochondromas (MO) is one of the most common benign bone tumors in humans with an autosomal dominant hereditary mode. MO is a genetic heterogeneity disease with variable number and size of osteochondromas, as well as changeable number and location of diseased bones. Mutations in Exostosin-1/Exostosin-2 (EXT1/EXT2) genes are the main molecular basis of MO. EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs)...
July 2017: Tohoku Journal of Experimental Medicine
Seishi Furukawa, Kazuko Miyakawa, Joichi Shibata, Mitsutoshi Iwashita
Maternal subclinical hypothyroidism may be associated with adverse pregnancy outcomes, although not consistently across regions. Here, we sought to determine the effect of elevated thyroid-stimulating hormone (TSH) on pregnancy outcomes in Japanese women without known medical complications. TSH was determined by dried blood spots at 8-20 weeks of gestation, and 3.0-10.0 μU/mL of TSH was considered as elevated TSH (eTSH). A retrospective study involving 167 cases of eTSH was conducted. Five hundred and seventy eight of controls with normal TSH and without thyroid antibodies were selected...
July 2017: Tohoku Journal of Experimental Medicine
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