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Tohoku Journal of Experimental Medicine

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https://www.readbyqxmd.com/read/28496029/a-newly-established-severity-scoring-system-in-predicting-the-prognosis-of-patients-with-severe-fever-with-thrombocytopenia-syndrome
#1
Bo Yang, Xiaoli Wang, Yaping Li, Anzhao Wu, Qian Liu, Yuyin Lu, Chengmin Yuan, Mingming Wang
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by novel Bunyavirus. Due to the peculiarity of SFTS, accurate assessment is difficult to achieve with the current score systems. This study aimed to establish a new severity scoring system in predicting the prognosis of patients with SFTS. We included 123 patients with SFTS: 92 patients (45 males and 47 females), aged 59 ± 12 years, in survive group and 31 patients (17 males and 14 females), aged 61 ± 10 years, in death group...
May 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28496015/determining-the-possible-etiology-of-hospital-acquired-pneumonia-using-a-clone-library-analysis-in-japan
#2
Kazuhiro Yatera, Shingo Noguchi, Kei Yamasaki, Toshinori Kawanami, Kazumasa Fukuda, Keisuke Naito, Kentaro Akata, Takashi Kido, Hiroshi Ishimoto, Noriho Sakamoto, Hatsumi Taniguchi, Hiroshi Mukae
Obtaining precise etiological information regarding causative bacteria is important for the proper use of antimicrobials in hospital-acquired pneumonia (HAP), which is associated with a high rate of mortality. The aim of this study was to comparatively investigate the bacterial diversity in bronchoalveolar lavage fluid (BALF) in Japanese patients with HAP by the clone library method using the 16S rRNA gene. This study included Japanese patients with HAP who were treated at our hospital and referring hospitals...
May 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28496014/prognostic-factors-for-in-hospital-and-long-term-survival-in-patients-with-acute-st-segment-elevation-myocardial-infarction-after-percutaneous-coronary-intervention
#3
Lin-Lin Hou, Chao Gao, Jun Feng, Zhen-Fei Chen, Jing Zhang, Yong-Jin Jiang, Xue-Xiang Li, Bang-Ning Wang
Acute ST segment elevation myocardial infarction (STEMI) is one of the causes of death and disability in patients with cardiovascular diseases. This study aimed to investigate the prognostic factors of in-hospital and long-term survival in patients with acute STEMI undergoing percutaneous coronary intervention (PCI). Patients with STEMI undergoing PCI were divided into the death group (n = 54) and the survival group (n = 306) based on the outcomes during hospitalization. The routine blood and biochemistry tests, Killip classes and global registry of acute coronary events (GRACE) risk score were detected...
May 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28484113/psychomotor-ability-in-children-prenatally-exposed-to-methylmercury-the-18-month-follow-up-of-tohoku-study-of-child-development
#4
Nozomi Tatsuta, Katsuyuki Murata, Miyuki Iwai-Shimada, Kozue Yaginuma-Sakurai, Hiroshi Satoh, Kunihiko Nakai
Fish contain nutrients essential to the developing fetal brain, but they are contaminated with methylmercury. The Tohoku Study of Child Development, now underway in the Sanriku coastal area of Miyagi prefecture, Japan, follows mother-child pairs to examine the risks and benefits of fish consumption during pregnancy, especially the effects of prenatal exposures to methylmercury, selenium, and docosahexaenoic acid (DHA) on child neurodevelopment. Children aged 18 months were administered the Bayley Scales of Infant Development second edition (BSID-II) and Kyoto Scale of Psychological Development (KSPD) in 2004-2008...
May 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28458336/alfacalcidol-increases-the-therapeutic-efficacy-of-ibandronate-on-bone-mineral-density-in-japanese-women-with-primary-osteoporosis
#5
Yukio Nakamura, Takako Suzuki, Mikio Kamimura, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato
Bisphosphonates (BPs) increase bone mineral density (BMD) through the inhibition of osteoclast activity. Among BPs, ibandronate (IBN) is a strong inhibitor of bone resorption. However, the effects of a vitamin D analogue, alfacalcidol (ALF), on IBN treatment for osteoporosis is unknown. Fifty-three treatment-naïve post-menopausal women with primary osteoporosis were recruited and divided into IBN-treatment group (IBN group) and IBN with ALF group (IBN/ALF group). IBN (1.0 mg) was intravenously injected once a month, with or without oral ALF (1...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28442640/left-recumbent-position-decreases-heart-rate-without-alterations-in-cardiac-autonomic-nervous-system-activity-in-healthy-young-adults
#6
Konosuke Sasaki, Mayu Haga, Yoichi Endo, Junko Fujiwara, Ryoko Maruyama
Some studies have reported that recumbent position may have advantages in patients with heart disease and in pregnancy. However, it remains controversial whether recumbent position affects autonomic nervous system activity and hemodynamics in healthy adults. The aim of this study was to evaluate alterations in heart rate variability (HRV) and hemodynamics in the supine, left recumbent and right recumbent positions in healthy young adults. A total of 80 participants aged 22.8 ± 3.1 years were enrolled in this observational study...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28420811/the-t-allele-of-rs8075977-in-the-5-flanking-region-of-the-pedf-gene-is-associated-with-reduced-risk-of-coronary-artery-disease-in-elderly-chinese-men
#7
Shou-Yuan Ma, Yuan-Yuan Guo, Shu-Xia Wang, Jin-Xin Shi, Jie Liu, Jian-Feng Liu, Ping Zhu
Coronary artery disease (CAD) is a multifactorial disease with a genetic component. Pigment epithelium-derived factor (PEDF) exerts anti-inflammatory, anti-oxidant, anti-thrombotic, and anti-angiogenic effects and thus has received increasing attention as a sensitive biomarker of atherosclerosis and CAD. To explore the potential association between PEDF single nucleotide polymorphisms (SNPs) and CAD, we performed this case-control study of consecutive elderly Chinese Han male patients (n = 416) and age-matched male controls (n = 528) without a history of CAD or electrocardiographic signs of CAD...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28413183/a-slc24a2-gene-variant-uncovered-in-pancreatic-ductal-adenocarcinoma-by-whole-exome-sequencing
#8
Lei Wang, Zhuo Shao, Shiyue Chen, Lu Shi, Zhaoshen Li
Pancreatic ductal adenocarcinoma (PDAC) presents as an aggressive malignancy caused by environmental and genetic factors. In order to identify causal genes for PDAC, we performed whole exome sequencing (WES) to detect gene mutations in seven pairs of PDAC tissue and adjacent non-tumor tissue samples. Finally, we found a new nonsynonymous single nucleotide variant (nsSNV) in solute carrier 24 family member 2 (SLC24A2) gene resulting in the substitution of native glutamic acid (E) into aspartic acid (D) at position of 287 amino acid (E287D) in SLC24A2 protein, and confirmed this variant by Sanger gene sequencing...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28392505/early-diagnosis-of-tuberculosis-associated-iga-nephropathy-with-esat-6
#9
Nan Zhao, Jing-Yi Sun, Hai-Ping Xu, Fu-Yun Sun
IgA nephropathy (IgAN) is the most common cause of primary renal diseases worldwide, and the early secreted antigenic target of 6 (ESAT-6) which was secreted by Mycobacterium tuberculosis (MTB) may be involved in the development and progression of IgAN. This study aimed to investigate the role of ESAT-6 for early diagnosis of IgAN caused by MTB infection. From 2011 to 2014, 21 patients with renal tuberculosis (RTB), 25 with IgAN, and 46 with IgAN infected with MTB (IgAN/MTB) were enrolled. Serum levels of antibodies against Mycobacterium tuberculosis antigen 85A (Ag85A) were measured by ELISA...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28381701/non-invasive-assessment-of-early-atherosclerosis-based-on-new-arterial-stiffness-indices-measured-with-an-upper-arm-oscillometric-device
#10
Yaping Zhang, Ping Yin, Zuojun Xu, Yushui Xie, Changqian Wang, Yuqi Fan, Fuyou Liang, Zhaofang Yin
The clinical significance of detecting early atherosclerosis is now widely recognized. Measurement methods available at present are usually not suitable for use in primary care where rapid screening for a large population is needed. The Arterial Velocity-pulse Index (AVI) and Arterial Pressure-volume Index (API) are new noninvasive arterial stiffness indices that can be rapidly measured using an oscillometric device. The purpose of this study was to determine whether high AVI and API values are predictive of early atherosclerosis prior to the onset of obstructive coronary artery disease (CAD)...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28381700/occult-hepatitis-b-virus-infection-in-hyperlipidemia-patients
#11
Liu Yang, Tingting Li, Wenmin Li, Xi Tang, Jinfeng Li, Ruiwen Long, Yongshui Fu, Jean-Pierre Allain, Chengyao Li
Chronic hepatitis B virus (HBV) infection is associated with lower prevalence of hyperlipidemia (HLP). However, occult HBV infection (OBI) in HLP patients has not yet been explored. OBI is defined as the presence of detectable HBV DNA in serum or liver tissue but undetectable HBV surface antigen in serum. In this study, 1,036 HLP patients and 1,134 replacement blood donor controls were recruited. Among them, 252 HLP patients and 255 blood donors with antibody to HBV core positive were selected and analyzed...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28381664/therapeutic-potential-of-docetaxel-plus-cisplatin-chemotherapy-for-myasthenia-gravis-patients-with-metastatic-thymoma
#12
Guoyan Qi, Peng Liu, Huimin Dong, Shanshan Gu, Hongxia Yang, Yinping Xue
The prognosis of myasthenia gravis (MG) in association with invasive or metastatic thymoma is usually worse, and therapeutic options are quite limited. Here, we retrospectively reported the therapeutic effect of docetaxel plus cisplatin (docetaxel/cisplatin) chemotherapy in 7 MG patients with metastatic thymoma. Previously, all patients underwent thymectomy at the first onset of thymoma. After the metastasis of thymoma, none of the patients received thymectomy due to unresectable conditions after surgeon's evaluation for great risk of myasthenic crisis (n = 5) or patients' refusal (n = 2)...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28367856/successful-management-of-gorham-stout-disease-in-the-cervical-spine-by-combined-conservative-and-surgical-treatments-a-case-report
#13
Satoshi Tateda, Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Susumu Ohtsu, Eiji Itoi, Hiroshi Ozawa
Gorham-Stout disease (GSD) is a rare condition characterized by intraosseous proliferation of endothelial-lined vessels and progressive osteolysis. The precise etiology and pathophysiology of the disease remain poorly understood. Current therapeutic options for GSD include chemotherapy, radiotherapy, and surgical resection, but the surgical treatment of GSD is difficult, especially in the spinal lesion. The indication of wide-margined resection was limited because of anatomical features. Herein, we report a case of GSD of the cervical spine in which the lesions were successfully stabilized with combined conservative and surgical treatments...
April 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28344213/over-expression-of-tbl1xr1-indicates-poor-prognosis-of-serous-epithelial-ovarian-cancer
#14
Ming Ma, Nina Yu
Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) is a core component of the NCoR/SMRT transcription co-repressor complex, and its role in regulating cancer progression has been reported. Serous epithelial ovarian cancer (EOC) is the most common histological type of EOC. Here we explored the significance of TBL1XR1 expression in predicting outcomes of patients with serous EOC. Real-time quantitative PCR analysis showed that the expression level of TBL1XR1 mRNA was significantly higher in EOC tissues compared with adjacent non-tumorous tissues...
March 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28344212/age-dependent-effects-of-prenatal-dexamethasone-exposure-on-immune-responses-in-male-rats
#15
Ming-Yi Chou, Li-Tung Huang, You-Lin Tain, Ho-Chang Kuo, Mao-Meng Tiao, Jiunn-Ming Sheen, Chih-Cheng Chen, Pi-Lien Hung, Kai-Sheng Hsieh, Hong-Ren Yu
Prenatal glucocorticoid therapy is indicated in preterm delivery to prevent respiratory distress. This study was designed to evaluate the age-dependent effects of prenatal dexamethasone (DEX) therapy on the immune system using a rat model. Pregnant Sprague-Dawley rats received an intraperitoneal injection of DEX (0.1 mg/kg/day) or saline (VEH) over gestational days 14-20. Male offspring were sacrificed at postnatal day 7 (D7; infant stage), D120 (young adult stage), and D180 (adult stage) for evaluation of leukocyte subsets and isolation of splenocytes...
March 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28321035/disaster-victim-identification-using-orthopedic-implants-in-the-2011-east-japan-earthquake-and-tsunami
#16
Norio Numata, Haruka Makinae, Wataru Yoshida, Masao Daimon, Hideki Murakami
On March 11, 2011, an earthquake (magnitude 9.0) devastated Japan's east coast, and the associated tsunami resulted in social and mechanical destruction. Search for the missing people is still ongoing. Surgical implants are common in the general population. Medical implants usually have lot numbers, and their forensic use is common for victim identification. This investigation was conducted mainly in the cities of Kamaishi and Otsuchi, both of which were affected by the tsunami disaster in 2011. We visited 6 mortuaries with the police between March 20 (9 days after the tsunami) and April 20 (40 days after the tsunami) to examine the presence of surgical scars and related information...
March 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28321034/galectin-9-as-a-predictive-marker-for-the-onset-of-immune-related-adverse-effects-associated-with-anti-ccr4-moab-therapy-in-patients-with-adult-t-cell-leukemia
#17
Tareg Omer Mohammed, Haorile Chagan-Yasutan, Yugo Ashino, Wakana Nakayama, Yayoi Takahashi, Taizo Shimomura, Tetsuhiro Fujimoto, Yuko Watanabe, Toshiro Niki, Hitoshi Suzushima, Toshio Hattori
Adult T-cell leukemia/lymphoma (ATL/ATLL) is one of the most malignant lymphomas with poor prognosis. ATL/ATLL cells express CC chemokine receptor 4, and mogamulizumab (anti-CCR4 monoclonal antibody) exhibits strong cytotoxicity for ATL/ATLL cells. We analyzed plasma samples of 6 patients with ATL/ATLL treated with chemotherapy followed by mogamulizumab therapy (mogatherapy) for changes in the levels of biomarkers in relation to immune-related adverse effects. As treatment is often associated with skin eruptions, we investigated the profiles of inflammatory cytokines, including galectin-9 (Gal-9), which becomes increased in various infectious diseases and allergic patients...
March 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28320987/association-between-mean-corpuscular-hemoglobin-concentration-and-future-depressive-symptoms-in-women
#18
Ju-Mi Lee, Sarah B Nadimpalli, Jin-Ha Yoon, Se Yeon Mun, Il Suh, Hyeon Chang Kim
Insufficient hemoglobin and depression share several symptoms and often occur in the same patients. Here, we sought to clarify their relationship by investigating two indices of oxygenation at the tissue level: mean corpuscular hemoglobin concentration (MCHC) and hemoglobin level. We hypothesized that MCHC would be more informative than hemoglobin levels. This prospective, longitudinal, community-based study included 337 participants (108 men and 229 women; age range, 38-87 years) who received evaluations of MCHC, hemoglobin levels and depressive symptom scores (DSS) during baseline and follow-up examinations, which were performed in 2008-2011 and 2010-2012, respectively...
March 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28260726/cooperation-between-single-handed-and-group-practices-ensures-the-replacement-of-gastrostomy-tubes-and-tracheal-cannulas-in-home-medical-care-settings
#19
Takuma Kimura, Satoru Yoshie, Rumiko Tsuchiya, Shohei Kawagoe, Satoshi Hirahara, Katsuya Iijima, Toru Akahoshi, Tetsuo Tsuji
In Japan, patients who require home medical care are increasing especially in the elderly. In home medical care settings, devices such as gastrostomy tubes, tracheal cannulas, and urethral catheters are usually replaced by visiting physicians or nurses. However, device replacement services are not always available in Japan. Unless device replacement services are sufficiently provided to patients at home, patients have to suffer various disadvantages, including a forced visit to a hospital for device replacement despite inability to walk...
March 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28250354/elevated-plasma-mir-29a-levels-are-associated-with-increased-carotid-intima-media-thickness-in-atherosclerosis-patients
#20
Cui-Zhong Liu, Qi Zhong, Yu-Qing Huang
Atherosclerotic cardiovascular diseases, such as coronary heart disease, have become a major public health problem all over the world. MicroRNA-29a (miR-29a) modulates expression levels of collagen, inflammatory reaction and other extracellular matrix mRNAs, while adiponectin (APN), a circulating protein secreted by adipocytes, has anti-inflammatory properties. Both play multifaceted roles in angiogenesis or vascular remodelling. However, little is known about plasma miR-29a and APN levels in patients with atherosclerosis...
March 2017: Tohoku Journal of Experimental Medicine
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