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Tohoku Journal of Experimental Medicine

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https://www.readbyqxmd.com/read/28321035/disaster-victim-identification-using-orthopedic-implants-in-the-2011-east-japan-earthquake-and-tsunami
#1
Norio Numata, Haruka Makinae, Wataru Yoshida, Masao Daimon, Hideki Murakami
On March 11, 2011, an earthquake (magnitude 9.0) devastated Japan's east coast, and the associated tsunami resulted in social and mechanical destruction. Search for the missing people is still ongoing. Surgical implants are common in the general population. Medical implants usually have lot numbers, and their forensic use is common for victim identification. This investigation was conducted mainly in the cities of Kamaishi and Otsuchi, both of which were affected by the tsunami disaster in 2011. We visited 6 mortuaries with the police between March 20 (9 days after the tsunami) and April 20 (40 days after the tsunami) to examine the presence of surgical scars and related information...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28321034/galectin-9-as-a-predictive-marker-for-the-onset-of-immune-related-adverse-effects-associated-with-anti-ccr4-moab-therapy-in-patients-with-adult-t-cell-leukemia
#2
Tareg Omer Mohammed, Haorile Chagan-Yasutan, Yugo Ashino, Wakana Nakayama, Yayoi Takahashi, Taizo Shimomura, Tetsuhiro Fujimoto, Yuko Watanabe, Toshiro Niki, Hitoshi Suzushima, Toshio Hattori
Adult T-cell leukemia/lymphoma (ATL/ATLL) is one of the most malignant lymphomas with poor prognosis. ATL/ATLL cells express CC chemokine receptor 4, and mogamulizumab (anti-CCR4 monoclonal antibody) exhibits strong cytotoxicity for ATL/ATLL cells. We analyzed plasma samples of 6 patients with ATL/ATLL treated with chemotherapy followed by mogamulizumab therapy (mogatherapy) for changes in the levels of biomarkers in relation to immune-related adverse effects. As treatment is often associated with skin eruptions, we investigated the profiles of inflammatory cytokines, including galectin-9 (Gal-9), which becomes increased in various infectious diseases and allergic patients...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28320987/association-between-mean-corpuscular-hemoglobin-concentration-and-future-depressive-symptoms-in-women
#3
Ju-Mi Lee, Sarah B Nadimpalli, Jin-Ha Yoon, Se Yeon Mun, Il Suh, Hyeon Chang Kim
Insufficient hemoglobin and depression share several symptoms and often occur in the same patients. Here, we sought to clarify their relationship by investigating two indices of oxygenation at the tissue level: mean corpuscular hemoglobin concentration (MCHC) and hemoglobin level. We hypothesized that MCHC would be more informative than hemoglobin levels. This prospective, longitudinal, community-based study included 337 participants (108 men and 229 women; age range, 38-87 years) who received evaluations of MCHC, hemoglobin levels and depressive symptom scores (DSS) during baseline and follow-up examinations, which were performed in 2008-2011 and 2010-2012, respectively...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28260726/cooperation-between-single-handed-and-group-practices-ensures-the-replacement-of-gastrostomy-tubes-and-tracheal-cannulas-in-home-medical-care-settings
#4
Takuma Kimura, Satoru Yoshie, Rumiko Tsuchiya, Shohei Kawagoe, Satoshi Hirahara, Katsuya Iijima, Toru Akahoshi, Tetsuo Tsuji
In Japan, patients who require home medical care are increasing especially in the elderly. In home medical care settings, devices such as gastrostomy tubes, tracheal cannulas, and urethral catheters are usually replaced by visiting physicians or nurses. However, device replacement services are not always available in Japan. Unless device replacement services are sufficiently provided to patients at home, patients have to suffer various disadvantages, including a forced visit to a hospital for device replacement despite inability to walk...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28250354/elevated-plasma-mir-29a-levels-are-associated-with-increased-carotid-intima-media-thickness-in-atherosclerosis-patients
#5
Cui-Zhong Liu, Qi Zhong, Yu-Qing Huang
Atherosclerotic cardiovascular diseases, such as coronary heart disease, have become a major public health problem all over the world. MicroRNA-29a (miR-29a) modulates expression levels of collagen, inflammatory reaction and other extracellular matrix mRNAs, while adiponectin (APN), a circulating protein secreted by adipocytes, has anti-inflammatory properties. Both play multifaceted roles in angiogenesis or vascular remodelling. However, little is known about plasma miR-29a and APN levels in patients with atherosclerosis...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28216546/bach2-controls-homeostasis-of-eosinophils-by-restricting-the-type-2-helper-function-of-t-cells
#6
Yuki Sato, Hiroki Kato, Risa Ebina-Shibuya, Ari Itoh-Nakadai, Ryuhei Okuyama, Kazuhiko Igarashi
Bach2 is a transcription factor which represses its target genes and plays important roles in the differentiation of B and T lymphoid cells. Bach2-deficient (KO) mice develop severe pulmonary alveolar proteinosis, which is associated with increased numbers of granulocytes and T cells. Bach2 is essential for the regulation of T cells, but its role in the regulation of granulocytes is not clear. Here, we observed increased numbers of eosinophils but not neutrophils in the bone marrow, spleen, peripheral blood, and bronchoalveolar lavage fluids of Bach2 KO mice compared with those of wild-type (WT) mice...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28202857/cytokine-profiles-in-pericardial-effusion-in-a-down-syndrome-infant-with-transient-abnormal-myelopoiesis
#7
Yoshihiko Shitara, Naoto Takahashi, Yoshinori Aoki, Motohiro Kato, Riki Nishimura, Shinya Tsuchida, Akira Oka
Infants with Down Syndrome (DS) are at risk of developing a transient abnormal myelopoiesis (TAM). TAM is characterised by increased circulating blast cells but usually self-limiting. DS patients with TAM sometimes show fetal hydrops and effusion in body cavities, but the mechanism remains unclear. We report here a case of infant with DS who had pericardial effusion, TAM, and eosinophilia. In her pericardial effusion, white blood cell count was 6.0 × 10(3)/µL, 41% of which were eosinophils. After administration of prednisolone, pericardial effusion gradually decreased, and TAM and eosinophilia improved...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28202856/plasma-monocyte-chemoattractant-protein-1-as-a-predictive-marker-for-sepsis-prognosis-a-prospective-cohort-study
#8
Tingting Zhu, Xuelian Liao, Ting Feng, Qihong Wu, Jiangqian Zhang, Xing Cao, Hong Li
Sepsis is a systemic host response to infection, and patients with sepsis are frequently handled in the intensive care unit. However, mortality related to sepsis remains high throughout the world. In addition, there have been no efficient prognostic biomarkers for sepsis to be employed in clinical practice. We therefore aimed to identify prognostic biomarkers for sepsis using the chemokine/cytokine array. This study included 143 patients with sepsis, who were divided into survivor and nonsurvivor groups according to their 28-day mortality status...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28202851/expression-of-inorganic-pyrophosphatase-ppa1-correlates-with-poor-prognosis-of-epithelial-ovarian-cancer
#9
Hui Li, Ning Xiao, Zongpeng Li, Qin Wang
Ovarian serous carcinoma (OSC) is the most common epithelial ovarian cancer. Inorganic pyrophosphatase (PPA1) catalyzes the hydrolysis of pyrophosphate to inorganic phosphate, thereby providing extra energy for metabolism. The significance of PPA1 in the prognosis of OSC has not been investigated. Our study aimed to explore the expression and predictive role of PPA1 in OSC progression. We screened the expression of PPA1 protein in OSC tissues from 139 patients by immunohistochemistry, and evaluated its correlation with clinicopathological characteristics...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28202850/hypermethylation-of-the-n-myc-downstream-regulated-gene-2-promoter-in-peripheral-blood-mononuclear-cells-is-associated-with-liver-fibrosis-in-chronic-hepatitis-b
#10
Xin-Yuan Liu, Yu-Chen Fan, Shuai Gao, Jing Zhao, Feng Li, Jun Zhang, Kai Wang
DNA methylation is a fundamental epigenetic modification to regulate gene expression. N-Myc downstream-regulated gene (NDRG) 2 is a cytoplasmic protein and participates in the pathogenesis of liver fibrosis. In this study, the mRNA expression and methylation status of NDRG2 was evaluated in patients with chronic hepatitis B (CHB). The study included 143 CHB patients and 65 normal controls (NC). The mRNA expression of NDRG2 in peripheral blood mononuclear cells (PBMCs) was detected by quantitative real-time polymerase chain reaction...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28190856/virilism-and-ectopic-expression-of-hsd17b5-in-mature-cystic-teratoma
#11
Yohei Kawaguchi, Hiroko Mizuno, Mai Horikawa, Mayuko Kano, Kengo Yamada, Fumiko Yamakawa, Takashi Maekawa, Yuto Yamazaki, Keely M McNamara, Hironobu Sasano, Masayuki Hayashi
Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28190855/high-maternal-age-and-low-pre-pregnancy-body-mass-index-correlate-with-lower-birth-weight-of-male-infants
#12
Sayuri Fukuda, Yurika Tanaka, Kiyomi Harada, Ayako Saruwatari, Kaori Kitaoka, Kiyoko Odani, Wataru Aoi, Sayori Wada, Yukari Nishi, Tatsuya Oguni, Hiroaki Asano, Nobuko Hagiwara, Akane Higashi
In Japan, the percentage of leanness has been increasing in young women, and the percentage of low birth weight infants (< 2,500 g) has increased. Moreover, the average age of primiparas rose 3.5 years during the last 30 years. The purpose of this study was to clarify the relationship between maternal age and the influence of maternal pre-pregnancy physique on the neonatal physique of infants. Questionnaires were issued to the participants and collected when they submitted their gestational notifications at their local ward office in Kyoto Prefecture...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28190825/excessive-game-playing-is-associated-with-poor-toothbrushing-behavior-among-athletic-children-a-cross-sectional-study-in-miyagi-japan
#13
Masahiro Tsuchiya, Haruki Momma, Takuya Sekiguchi, Kaoru Kuroki, Kenji Kanazawa, Makoto Watanabe, Yoshihiro Hagiwara, Ryoichi Nagatomi
Dental problems among athletes have been cautioned due to negative impacts not only on their oral health but also on athletic performance. Acquirement of appropriate oral health behavior mainly composed of toothbrushing in childhood can be one of the most important strategies for advancing children's athletic possibilities. Although habits of screen viewing, including game playing, and TV viewing have direct impacts on children's health and behavioral development, little is known about the association between these habits and toothbrushing frequency...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28163296/decontamination-reduces-radiation-anxiety-and-improves-subjective-well-being-after-the-fukushima-accident
#14
Michio Murakami, Shigeki Harada, Taikan Oki
Since the 2011 Fukushima accident, rebuilding society to protect against anxiety and improve feelings of well-being has grown in importance. A questionnaire was carried out among residents of Marumori Town, Igu County, Miyagi Prefecture, to evaluate the effects of radiation-related countermeasures implemented by the town to reduce residents' anxiety and improve their subjective well-being (response rate: 31%; valid responses: n = 174). Further, to propose effective countermeasures regarding town planning for the improvement in subjective well-being, we analyzed associations between residents' sense of attachment to the town and subjective well-being, and then identified primary factors behind their sense of attachment...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28154346/unequal-accessibility-of-nurseries-for-sick-children-in-over-and-under-populated-areas-of-japan
#15
Akira Ehara
Infants and toddlers are prone to rapidly contracting illnesses, which are usually attributed to infectious diseases. Most nurseries and schools in Japan, however, refuse to accept children even with mild illnesses. For working parents, a sick child may therefore create new problems as the situation requires new day-care arrangements. To support such families, the Japanese government subsidizes construction and management of nurseries that operate especially for sick children. However, it has not been known whether most families are able to access such nurseries...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28154345/elevated-serum-levels-of-interleukin-29-are-associated-with-disease-activity-in-rheumatoid-arthritis-patients-with-anti-cyclic-citrullinated-peptide-antibodies
#16
Qiong-Jie Chang, Cheng Lv, Feng Zhao, Ting-Shuang Xu, Ping Li
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that may lead to progressive joint destruction. The anti-cyclic citrullinated peptide (anti-CCP) antibody is an essential marker for the diagnosis of RA and has a crucial role in the bone destruction in RA. Recent studies have shown that interleukin (IL)-29, a vital member of type III interferon (IFN) family, could enhance proinflammatory cytokine production and might be involved in the joint destruction in RA. Therefore, in this study, we aimed to examine the role of IL-29 in RA patients with anti-CCP antibodies...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28132967/kidney-cadmium-toxicity-diabetes-and-high-blood-pressure-the-perfect-storm
#17
Soisungwan Satarug, David A Vesey, Glenda C Gobe
Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the body uses for acquisition of physiologically-essential elements, notably of iron, zinc and calcium. Currently, human exposure to Cd is known to damage the kidneys, especially the proximal tubular cells that actively reabsorb Cd along with zinc, glucose and amino acids in the glomerular filtrate. Severe kidney damage, glycosuria and proteinuria are known outcomes after high dietary Cd intake (> 200 µg/day)...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28123165/transcription-factor-sox9-promotes-osteosarcoma-cell-growth-by-repressing-claudin-8-expression
#18
Jin Qi, Yaoqi Yang, Ping Hao, Jianqiang Xu
Osteosarcoma is a malignant bone cancer that mainly affects children. SOX9 plays a key role in bone formation and osteosarcoma, and Claudin-8 (CLDN8), a tight junction protein, contributes to proliferation of osteosarcoma cells. The aim of this study was to investigate the relationship between SOX9 and CLDN8 in osteosarcoma. The expression levels of SOX9 and CLDN8 were determined in osteosarcoma specimens (n = 25) by qRT-PCR and Western blot analyses. The levels of SOX9 mRNA and protein were significantly higher in osteosarcoma tissues than those in adjacent non-tumor tissues, whereas the expression levels of CLDN8 mRNA and protein were significantly lower in osteosarcoma tissues...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28090038/combination-therapy-with-ombitasvir-paritaprevir-ritonavir-for-dialysis-patients-infected-with-hepatitis-c-virus-a-prospective-multi-institutional-study
#19
Ken Sato, Kenichi Hosonuma, Yuichi Yamazaki, Takeshi Kobayashi, Satoshi Takakusagi, Norio Horiguchi, Satoru Kakizaki, Motoyasu Kusano, Hiroshi Ohnishi, Hiroaki Okamoto, Masanobu Yamada
Hepatitis C virus (HCV) infection is common in dialysis patients worldwide and nosocomial HCV spread within dialysis facilities continues to develop. Combination therapy with daclatasvir and asunaprevir (DCV/ASV) that has proven efficacy for dialysis patients infected with genotype 1b HCV (HCV/1b) has several concerns in Japan. The recently available combination therapy with ombitasvir, paritaprevir, and ritonavir (OBV/PTV/r) is not contraindicated in patients with chronic renal failure and has more safety profile and shorter treatment period than that with DCV/ASV...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28090037/expression-of-pro-renin-receptor-during-rapamycin-induced-erythropoiesis-in-k562-erythroleukemia-cells-and-its-possible-dual-actions-on-erythropoiesis
#20
Kiriko Kaneko, Koji Ohba, Takuo Hirose, Kazuhito Totsune, Kazumichi Furuyama, Kazuhiro Takahashi
(Pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, is expressed in erythroblastic cells. (P)RR has multiple biological actions: prorenin activation, stimulation of the intracellular signaling including extracellular signal-regulated kinases, and functional complex formation with vacuolar H(+)-ATPase (v-ATPase). However, the functional implication of (P)RR in erythroblast cells has not been clarified. The aim of the present study was to clarify changes of (P)RR expression during erythropoiesis and a role of (P)RR in the heme synthesis...
2017: Tohoku Journal of Experimental Medicine
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