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Tohoku Journal of Experimental Medicine

Tracey Elizabeth Claire Jones-Konneh, Tomomi Suda, Hiroyuki Sasaki, Shinichi Egawa
Healthcare workers (HCWs) are often exposed to nosocomial infection when caring for patients with Ebola Virus Disease (EVD). During the 2014-2016 EVD outbreak in West Africa, more than 200 HCWs died of EVD in Sierra Leone. To determine the factors that are important for preventing infection among HCWs during EVD outbreak, we used agent-based modeling and simulation (ABMS) by focusing on education, training and performance of HCWs. Here, we assumed 1, 000 HCWs as "agents" to analyze their behavior within a given condition and selected four parameters (P1-P4) that are important in the prevention of infection: "initially educated HCWs (P1)", "initially educated trained (P2)", "probability of seeking training (P3)" and "probability of appropriate care procedure (P4)...
August 2018: Tohoku Journal of Experimental Medicine
Van Minh Ho, Nobuyuki Hirohashi, Weng-Sheng Kong, Guo Yun, Kohei Ota, Junji Itai, Satoshi Yamaga, Kei Suzuki, Koichi Tanigawa, Masamoto Kanno, Nobuaki Shime
Immunoparalysis is a common cause of death for critical care patients with sepsis, during which comprehensive suppression of innate and adaptive immunity plays a significant pathophysiological role. Although the underlying mechanisms are unknown, damage-associated molecular patterns (DAMPs) from septic tissues might be involved. Therefore, we surveyed sera from septic patients for factors that suppress the innate immune response to DAMPs, including adenosine triphosphate (ATP), monosodium urate, and high mobility group box-1...
July 2018: Tohoku Journal of Experimental Medicine
Kento Morozumi, Keiko Ainoya, Jun Takemoto, Kiyohide Sakai
Campomelic dysplasia (CD) is a skeletal dysplasia characterized by shortened and bowed long bones, airway instability, the potential for disorders of sexual differentiation (DSD), and Pierre Robin Sequence (PRS) with cleft palate, midface hypoplasia and laryngotrachemomalacia. CD is caused by alterations in the Sex-determining region of the Y chromosome (SRY)-related-box 9 (SOX9), which has important roles in tissue and sexual differentiation. The SOX9 gene and the enhancer regions of SOX9 are located at chromosome 17q24...
July 2018: Tohoku Journal of Experimental Medicine
Eiko Onishi, Mamoru Murakami, Ryo Nishino, Ruri Ohba, Masanori Yamauchi
Thoracic epidural anesthesia (TEA) and paravertebral block (PVB) have been performed for perioperative regional anesthesia in the trunk. However, TEA and PVB are associated with a risk of serious complications, such as pneumothorax, hypotension, or nerve damage. Retrolaminar paravertebral block (RLB) was introduced as a new alternative to PVB. This new approach might lower the risk of serious complications, but its use has not been well established yet. Therefore, we conducted a double-masked, placebo-controlled, randomized clinical trial to evaluate the efficacy of a double-level RLB for postoperative analgesia after breast cancer surgery...
July 2018: Tohoku Journal of Experimental Medicine
Yasuaki Saijo, Eiji Yoshioka, Sharon J B Hanley, Kazuyo Kitaoka, Takahiko Yoshida
Shortage of healthcare workers is a global problem. It is important to clarify factors, including job stress, that influence workplace resignation and factors that cause burnout among rural physicians. The study was designed as a cross-sectional questionnaire survey. We sent questionnaires to town or village hospitals and clinics (n = 1,898) in Hokkaido, Tohoku, Shikoku, and Kyushu and Okinawa. The number of participants was 509. Of these 7.7% were female and 21.6% were < 50 years. Internal or general medicine physicians were asked about personal and job factors, job stress based on the demand-control-support model, intention to resign from current position, and burnout evaluated using the Maslach Burnout Inventory-General Survey...
July 2018: Tohoku Journal of Experimental Medicine
Fumiyoshi Fujishima, Hiroki Katsushima, Noriko Fukuhara, Sachiko Konosu-Fukaya, Yasuhiro Nakamura, Hironobu Sasano, Ryo Ichinohasama
Primary gastrointestinal lymphoma (PGIL) has been reported in many studies of lymphomas of the gastrointestinal tract worldwide. However, there have been few accurate population-based reports on lymphomas, and it is difficult to apply the strict definition of PGIL to all lymphomas occurring in the gastrointestinal tract. Accordingly, instead of using PGIL, this study included newly diagnosed lymphomas with biopsy or excision specimens obtained from the gastrointestinal tract (GI-related lymphomas) and aimed at presenting the incidence rate, subtype frequency, and occurrence site of GI-related lymphomas...
July 2018: Tohoku Journal of Experimental Medicine
Akira Ehara
Access to day-care services for children with mild acute illness is important for working parents, because infants and toddlers often suddenly become ill, and most Japanese nursery schools do not accept children with even mild illnesses. Actual travel time to nurseries providing such day-care services is one of the indicators for measuring accessibility. However, this variable has not been well analyzed in previous work. To clarify practical access to such nurseries, this study used a car navigation algorithm to calculate the percentage of the population of children in Japan who can access nurseries providing services for children with mild acute illnesses within 15 to 30 minutes and compared this with the proportion of children living within a linear distance of 10 km of such nurseries...
July 2018: Tohoku Journal of Experimental Medicine
Tomonori Sato, Yoshihide Kawasaki, Akihiro Ito, Hideaki Izumi, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Tomonori Matsuura, Mika Watanabe, Yoichi Arai
Tubulointerstitial nephritis is primary injury to renal tubules and interstititum which could be resulting in decreased renal function. The acute and chronic forms are most often due to allergic drug reactions or to infections. Tubulointerstitial nephritis in Crohn's disease has rarely been reported. Imaging findings of a striated nephrogram on enhanced computed tomography (CT) could represent the clinical state of tubulointerstitial nephritis. This is the first report of tubulointerstitial nephritis caused by infliximab, monoclonal antibody against human tumor necrosis factor-α, showing striated nephrograms in Crohn's disease...
July 2018: Tohoku Journal of Experimental Medicine
Zunxian Yang, Hongwei Shen, Weipeng He, Linlong Ouyang, Yunyun Guo, Fang Qian, Baoduan Xu, Dan Xie, Guofen Yang
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy with high recurrence and poor prognosis duo to the lack of effective biomarkers. TBC1 domain family member 16 (TBC1D16), a GTPase-activating protein, is involved in regulating intracellular trafficking in tumorigenesis and metastasis. However, the clinical significance of TBC1D16 in EOC remains unknown. In the present study, we investigated the expression and prognostic significance of TBC1D16 in EOC and its relationship with the expression of vascular endothelial growth factor (VEGF)...
July 2018: Tohoku Journal of Experimental Medicine
Thuy Thu Nguyen, Shoichi Suzuki, Ryuichi Sugamata, Fuyu Ito, Dat Huu Tran, Tomoko Yamamoto, Shoji Kawachi, Kazuo Suzuki
Pattern recognition receptors recognize RNA viruses and trigger type I and III interferon (IFN) production and apoptosis to limit viral replication and spread. Some innate immune cells produce oxidants in response to viral infection to protect against invasion. Recent studies have demonstrated the virucidal activity of hypothiocyanous acid (HOSCN), an oxidant generated by the peroxidase-catalyzed reaction of thiocyanate with hydrogen peroxide. However, the effects of HOSCN on host antiviral responses are still unknown...
June 2018: Tohoku Journal of Experimental Medicine
Guannan Chang, Wenqing Zhang, Yun Ma, Qiang Wen
PTEN-induced putative kinase protein 1 (PINK1) is a serine/threonine-protein kinase that phosphorylates mitochondrial proteins and is involved in mitophagy. Thus, PINK1 may protect cancer cells against mitochondrial dysfunction during cellular stress. However, the role of PINK1 in lung cancer was rarely explored. In this study, we immunohistochemically analyzed the expression of PINK1 in 256 patients with non-small-cell lung cancer, consisting of 137 patients with adenocarcinoma (AC) and 119 patients with squamous cell carcinoma (SCC)...
June 2018: Tohoku Journal of Experimental Medicine
Akira Okita, Hiroo Imai, Masahiro Takahashi, Hidekazu Takahashi, Sho Umegaki, Yoshifumi Kawamura, Sakura Hiraide, Kota Ouchi, Yuko Sato, Yoshinari Okada, Keigo Komine, Ken Saijo, Shin Takahashi, Masanobu Takahashi, Hidekazu Shirota, Hisatsugu Ohori, Makio Gamoh, Chikashi Ishioka
The combinations of oral fluoropyrimidines and cisplatin such as capecitabine and cisplatin (XP) or S-1 and cisplatin (SP) are regarded as a standard therapy against unresectable, recurrent, or advanced gastric cancer (AGC). Especially, SP is the most common regimen against AGC in Japan. For patients with human epidermal growth factor receptor type 2 (HER2)-positive AGC, trastuzumab, a monoclonal antibody targeting HER2 antibody, is additionally used in combination. Although trastuzumab in combination with XP (trastuzumab-XP) have been widely accepted, the efficacy of trastuzumab in combination with SP (trastuzumab-SP) lacks sufficient verification...
June 2018: Tohoku Journal of Experimental Medicine
Mie Yamanaka, Kiyoto Shiga, Sho Fujiwara, Yasuhiko Mizuguchi, Sari Yasuda, Kota Ishizawa, Yuriko Saiki, Kenjiro Higashi, Takenori Ogawa, Noriko Kimura, Akira Horii
Pheochromocytomas and paragangliomas are neuroendocrine tumors which arise from adrenal medulla, and sympathetic or parasympathetic nerves, respectively. Hereditary cases afflicted by both or either pheochromocytomas and paragangliomas have been reported: these are called hereditary pheochromocytoma/paraganglioma syndromes (HPPS). Many cases of HPPS are caused by mutations of one of the succinate dehydrogenase (SDH) genes; mainly SDHB and SDHD that encode subunits for the mitochondrial respiratory chain complex II...
June 2018: Tohoku Journal of Experimental Medicine
Takayuki Takeda, Mayumi Takeuchi, Masahiko Saitoh, Sorou Takeda
Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable disease with limited overall survival. Nintedanib is a multikinase inhibitor, and its efficacy on IPF was demonstrated in phase III trials. However, a discrepancy exists between forced vital capacity (FVC) and patient-reported outcomes during nintedanib treatment. Accordingly, we retrospectively analyzed the effects of nintedanib on FVC and patient-reported outcomes among 25 IPF patients. Patient-reported outcomes were evaluated with modified medical research council (mMRC) grade and COPD assessment test (CAT) score...
June 2018: Tohoku Journal of Experimental Medicine
Hai-Rong Zhu, Ren-Zheng Huang, Xiang-Nan Yu, Xuan Shi, Enkhnaran Bilegsaikhan, Hong-Ying Guo, Guang-Qi Song, Shu-Qiang Weng, Ling Dong, Harry L A Janssen, Xi-Zhong Shen, Ji-Min Zhu
Hepatocellular carcinoma (HCC) remains a major health problem for delayed diagnosis, inefficient surveillance and poor prognosis. Recent studies have indicated that non-coding RNAs contribute to the development of new strategies for diagnosis and treatment of HCC. In the present study, we employed 18 pairs of HCC and matched non-tumor tissues for the identification of differentially expressed microRNAs (miRNAs) in HCC, among which 7 paired specimens were selected randomly for microarray detection. Totally, twenty-three miRNAs were screened out to have statistically significant differences with the threshold of P < 0...
June 2018: Tohoku Journal of Experimental Medicine
Kyeongbong Lee, Ji-Eun Cho, Dal-Yeon Hwang, WanHee Lee
The abdominal muscles play a role in trunk balance. Abdominal muscle thickness is asymmetrical in stroke survivors, who also have decreased respiratory muscle function. We compared the thickness of the abdominal muscles between the affected and less affected sides in stroke survivors. In addition, the relationship between respiratory muscle function and trunk balance was evaluated. Chronic stroke patients (18 men, 15 women; mean age, 58.94 ± 12.30 years; Mini-Mental Status Examination score ≥ 24) who could sit without assist were enrolled...
June 2018: Tohoku Journal of Experimental Medicine
Chu Chen, Guo-Feng Bao, Guanhua Xu, Yuyu Sun, Zhi-Ming Cui
Facet joint osteoarthritis is common lumbar osteoarthritis characterized by facet joint cartilage degeneration. However, the molecular basis of facet joint osteoarthritis remains largely undetermined. In the current study, we collected facet joint tissue samples from 10 control patients and 48 patients with facet joint osteoarthritis (20 patients with moderate degeneration and 28 with severe degeneration). The control patients underwent internal fixation of the lumbar spine due to vertebral fracture. RNA deep sequencing was performed, and Bioinformatic tools were applied...
May 2018: Tohoku Journal of Experimental Medicine
Zhuoyu Chen, Xiaofeng Yin, Kaifei Li, Shuyu Chen, Haixia Li, Yao Li, Qiong Zhang, Haifang Wang, Yurong Qiu
Colon cancer is one of the most common malignancies causing the majority of cancer-related deaths worldwide. The tripartite motif family protein 72 (TRIM72), also known as mitsugumin 53, acts as an E3 ubiquitin ligase. TRIM72 is involved in insulin resistance and metabolic syndrome, which are risk factors of colon cancer. However, the correlation between TRIM72 and colon cancer remains unknown. In the present study, we explored the expression profile of TRIM72 in colon cancer tissues and the diagnostic value of serum TRIM72 in colon cancer...
May 2018: Tohoku Journal of Experimental Medicine
Hiroki Miyabayashi, Satoru Kumaki, Atsushi Sato, Ryoichi Onuma, Rie Noguchi, Taiki Sato, Takaya Metoki, Yohei Watanabe, Yusaku Tazawa, Masue Imaizumi, Setsuko Kitaoka
Hemophagoytic lymphohistiocytosis (HLH) is a rare life-threatening disorder caused by overactivation of the immune system, associated with infections, autoimmune disorders, and malignancies. The pathological hallmark of HLH is phagocytosis of blood cells and platelets by activated macrophages and histiocytes. In this report, we describe the onset of HLH in three children, aged 2, 5 and 7 years old, during the treatment of acute focal bacterial nephritis (AFBN) with an antibiotic, piperacillin-tazobactam (PIPC-TAZ)...
May 2018: Tohoku Journal of Experimental Medicine
Masumi Takeuchi, Kyoko Nomura, Saki Horie, Hiroko Okinaga, Chithra R Perumalswami, Reshma Jagsi
The purpose of this study is three-fold: (1) to compare harassment (sexual, gender, and academic harassment both directly and indirectly experienced - i.e. "directly harassed" and "have seen or heard of someone who experienced harassment", respectively) experienced by males and females, (2) to investigate whether such experiences correlate with burnout, and (3) to explore whether social support might mitigate any such relationship between harassment and burnout. This cross-sectional study was conducted at a private university in Japan in February 2014 and is based on a work-life balance survey obtained from 330 academic faculty members...
May 2018: Tohoku Journal of Experimental Medicine
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