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Tohoku Journal of Experimental Medicine

Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima, Masashi Aoki
Distal symmetric polyneuropathy, represented by chronic inflammatory demyelinating polyneuropathy, is a popular neurological condition. Some cases are known to be associated with genetic mutations or serum auto-antibodies, but the exact mechanisms in most cases are unknown. Recently, osmotic factors have been suggested to trigger some neurological disorders, such as neuromyelitis optica. The aim of the present study was to assess the possible association of osmotic factors in the pathogenesis of distal polyneuropathy...
September 2018: Tohoku Journal of Experimental Medicine
Lu Wang, Feng Wang, Juan Liu, Qiang Zhang, Ping Lei
Mild cognitive impairment (MCI) is the prophase of dementia. MCI patients have a high risk of developing dementia. Relatively low serum albumin levels are associated with the development of several geriatric diseases, including stroke and poor cognitive performance. However, the potential relationship between serum albumin levels and MCI risk has not been fully elucidated. In the present study, we explored this relationship to increase our understanding of the pathogenesis of MCI, the finding of which may provide new ideas for the controlling of dementia...
September 2018: Tohoku Journal of Experimental Medicine
Ye-Ran Lee, Jun-Seon Choi, Hee-Eun Kim
Hearing loss is a common disease in older adults. In order to lower the prevalence of hearing loss, it is important to identify its risk factors. Although some studies have found a relationship between dental status and hearing acuity, few studies have investigated the relationship between unilateral chewing and hearing acuity. This study aimed to assess the effects of unilateral chewing on hearing acuity, with a focus on the risk of hearing loss. Eighty-one participants (aged 51-87 years) were included in the present study...
September 2018: Tohoku Journal of Experimental Medicine
Tanja M Radic, Vesna M Coric, Marija S Pljesa-Ercegovac, Gordana M Basta-Jovanovic, Sanja M Radojevic-Skodric, Dejan P Dragicevic, Marija G Matic, Ljiljana M Bogdanovic, Zoran M Dzamic, Tatjana P Simic, Ana R Savic-Radojevic
Glutathione S-transferases (GSTs), a superfamily of multifunctional enzymes, play an important role in the onset and progression of renal cell carcinoma (RCC). However, novel GST omega class (GSTO), consisting of GSTO1-1 and GSTO2-2 isoenzymes, has not been studied in RCC yet. Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers...
September 2018: Tohoku Journal of Experimental Medicine
Hyo Kyozuka, Keiya Fujimori, Mitsuaki Hosoya, Seiji Yasumura, Tadahiko Yokoyama, Akiko Sato, Koichi Hashimoto
Japan Environment and Children's Study (JECS) is nationwide birth cohort study that was initiated in January 2011 to investigate the effect of environmental factors on children's health. Soon after the JECS started, the Great East Japan Earthquake occurred on March 11, 2011, with subsequent nuclear accident at the Fukushima Daiichi Nuclear Power Plant, causing catastrophic damage in Fukushima Prefecture. After the disaster, JECS was relaunched to cover all areas in Fukushima Prefecture due to public concern...
September 2018: Tohoku Journal of Experimental Medicine
G M Rabiul Islam, Isao Igarashi, Koichi Kawabuchi
The World Health Organization recommends continuing breastfeeding up to 2 years of age or beyond for sound growth and development of children. In Bangladesh, continuation rates for breastfeeding have recently decreased and effective measures are required to counter this downward trend. Although recent years have seen economic development and reductions in poverty, Bangladesh still has the highest rate of child marriage worldwide. Thus, we aimed to clarify the factors influencing breastfeeding continuation, especially from the perspective of inequality and mother's age in Bangladesh, using data from the Bangladesh Demographic and Health Survey 2011...
September 2018: Tohoku Journal of Experimental Medicine
Yutaka Yabe, Yoshihiro Hagiwara, Takuya Sekiguchi, Yumi Sugawara, Masahiro Tsuchiya, Masashi Koide, Nobuyuki Itaya, Shinichirou Yoshida, Yasuhito Sogi, Toshihisa Yano, Ichiro Tsuji, Eiji Itoi
Lower back pain (LBP) is a common health problem after natural disasters. Although some related factors have been reported, the effect of sleep disturbances on LBP is not clear. The purpose of this study was to elucidate the influence of sleep disturbances on LBP after the Great East Japan earthquake (GEJE). A panel study was conducted with the survivors of the GEJE (n = 2,295) at three and four years after the disaster using self-reported questionnaires. The changes in the presence of LBP during the two periods were assessed; LBP was characterized as either new onset or continuation of LBP...
September 2018: Tohoku Journal of Experimental Medicine
Miki Ichinomiya, Akinori Shimada, Naoki Ohta, Erina Inouchi, Kikumi Ogihara, Yuko Naya, Masaki Nagane, Takehito Morita, Masahiko Satoh
Cisplatin is a chemotherapeutic widely used in the treatment of various types of solid tumors. Acute kidney injury is the most critical dose-limiting factor in cancer patients treated with cisplatin; mitochondrial dysfunction and resultant cell damage by reactive oxygen species released from damaged mitochondria are suspected to be involved in the kidney injury. Pathological features of mitochondrial damage in relation to cisplatin-mediated nephrotoxicity, however, is not fully described. The purpose of this study was to demonstrate mitochondrial damage and clearance of damaged mitochondria by mitophagy in cisplatin-mediated nephrotoxicity...
September 2018: Tohoku Journal of Experimental Medicine
Jun Miyaguchi, Kiyoto Shiga, Kazumi Ogawa, Fumiko Suzuki, Katsunori Katagiri, Daisuke Saito, Aya Ikeda, Akira Horii, Mika Watanabe, Shizunobu Igimi
Bacteria have been used for more than a century to treat solid tumors. Because solid tumors generate an anaerobic environment, we evaluated the anti-tumor effect of the obligate anaerobe strain KK378, derived from Lactobacillus casei (L. casei), using mice bearing head and neck cancer. Wild-type L. casei is a nonpathogenic bacterium that is commonly used in foods. Moreover, patients with head and neck squamous cell carcinoma often have multiple cancers and cervical lymph node metastasis that can be directly sensed beneath the skin...
August 2018: Tohoku Journal of Experimental Medicine
Kyoko Kawaida, Hisashi Yoshimoto, Ryohei Goto, Go Saito, Yasukazu Ogai, Nobuaki Morita, Tamaki Saito
Excessive drinking by college students is a major public health problem in Japan. However, data on heavy episodic drinking (HED) and nomihodai, a several-hour all-you-can-drink system, are scarce. We surveyed the drinking behavior of undergraduate and graduate students at 35 colleges, and examined the association between HED and use of nomihodai. The study used a cross-sectional design conducted by a self-administered questionnaire. From December 2016 to March 2017, we sampled undergraduate and graduate students aged 20 or older at 35 colleges in the Kanto area, including Tokyo...
August 2018: Tohoku Journal of Experimental Medicine
Hiroki Chiba, Tomoaki Ogata, Michiya Ito, Sayuri Kaneko
An important consideration in the quality of end-of-life care is whether the patient's place of death matches his or her hopes. We aimed to identify topics related to patients' home death by comparing the occurrence frequency of topics explained by doctors for family caregivers between the home death cases and the hospital death cases. The method of integrating qualitative and quantitative data was adopted in this study. Primary participants were 24 home doctors who specialized home medical care. Enrolled 18 patients received periodical medical care by cooperated doctors, understood their own health situation, and lived with family caregivers...
August 2018: Tohoku Journal of Experimental Medicine
Ai Hamasaki, Nobuhiko Akazawa, Toru Yoshikawa, Kanae Myoenzono, Kaname Tagawa, Seiji Maeda
Cerebral hemodynamics plays an important role in cognitive performance, and as such, age-related cognitive dysfunction and cerebral hypoperfusion increase the risk of dementia. However, age-related changes in cerebral oxygenation and cognitive function remain unclear. The aim of this study was to investigate age-related declines in cerebral oxygenation and executive function cross-sectionally. Ninety-eight healthy Japanese adults (age range: 23-79 years; 40 males, 58 females) participated in the present study using local advertisements...
August 2018: Tohoku Journal of Experimental Medicine
Won Young Lee, Geehae Jung, Hye Ryun Kim, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee
Osteocalcin is the non-collagenous protein produced by osteoblasts in bone. When it is released into systemic circulation in its uncarboxylated form, it regulates fat and glucose metabolism. Recent studies have shown that osteocalcin is also involved in male fertility. Because the onset of puberty is determined by ethnic, genetic, environmental, and metabolic factors, we focused on determining the role of osteocalcin in the onset of puberty. Central precocious puberty (CPP) is defined as the activation of the hypothalamic-pituitary-gonadal axis before the age of 8 in girls and 9 in boys...
August 2018: Tohoku Journal of Experimental Medicine
Tracey Elizabeth Claire Jones-Konneh, Tomomi Suda, Hiroyuki Sasaki, Shinichi Egawa
Healthcare workers (HCWs) are often exposed to nosocomial infection when caring for patients with Ebola Virus Disease (EVD). During the 2014-2016 EVD outbreak in West Africa, more than 200 HCWs died of EVD in Sierra Leone. To determine the factors that are important for preventing infection among HCWs during EVD outbreak, we used agent-based modeling and simulation (ABMS) by focusing on education, training and performance of HCWs. Here, we assumed 1, 000 HCWs as "agents" to analyze their behavior within a given condition and selected four parameters (P1-P4) that are important in the prevention of infection: "initially educated HCWs (P1)", "initially educated trained (P2)", "probability of seeking training (P3)" and "probability of appropriate care procedure (P4)...
August 2018: Tohoku Journal of Experimental Medicine
Yasuka Nakamura, Mari Sato, Ikue Watanabe
During pregnancy, women experience various emotional changes. Previous research has investigated positive emotion influenced childbirth outcomes positively. This study explored the extent of positive emotion which pregnant women aware of their own pregnancy life subjectively and variables related to the changes thereof. This was an adjunct study of the Japan Environment and Children's Study which is a nationwide epidemiological study to identify the impact of environmental factors on health and development of children in Miyagi Prefecture...
August 2018: Tohoku Journal of Experimental Medicine
Chiaki Kawakami, Atsuo Sato, Hiroko Sumita, Atsushi Isozaki, Hiroyuki Shimizu, Taichi Kanetaka, Koji Maehara, Kota Ao, Akiyoshi Nariai, Fumihiko Takeshita, Rika Kizu, Masaaki Mori
The most important risk factor for severe respiratory syncytial virus (RSV) infection is considered young age due to the immature immune system. The risk at young age is reported greater for RSV than for other respiratory infectious agents. Based on the strong association between young age and severity of RSV infection due to immature immunity, we aimed to assess whether there were any age-related differences in fever responses, as one clinical aspect of the immune response. In our observational study over two seasons (2014-2015 and 2015-2016), daily body temperatures of children under 3 years old with RSV infection were recorded from the first medical visit during the acute phase to defervescence...
July 2018: Tohoku Journal of Experimental Medicine
Xiaoxin Zhang, Jia Guo, Haoyang Wang, Chenlong Zhang, Na Shi, Wenhao Cai, Tao Jin, Ziqi Lin, Yun Ma, Xiaonan Yang, Qing Xia, Ping Xue
Receptor for activated C kinase 1 (RACK1) plays an important role in regulating the immune response and cytokine expression. However, little is known about its role in acute pancreatitis (AP). We therefore investigated the role of RACK1 in AP and explored its relationship with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), both of which are related to AP severity. Two rat models of chemically induced AP with different severities were used: acute edematous pancreatitis (AEP) and acute necrotizing pancreatitis (ANP)...
July 2018: Tohoku Journal of Experimental Medicine
Van Minh Ho, Nobuyuki Hirohashi, Weng-Sheng Kong, Guo Yun, Kohei Ota, Junji Itai, Satoshi Yamaga, Kei Suzuki, Koichi Tanigawa, Masamoto Kanno, Nobuaki Shime
Immunoparalysis is a common cause of death for critical care patients with sepsis, during which comprehensive suppression of innate and adaptive immunity plays a significant pathophysiological role. Although the underlying mechanisms are unknown, damage-associated molecular patterns (DAMPs) from septic tissues might be involved. Therefore, we surveyed sera from septic patients for factors that suppress the innate immune response to DAMPs, including adenosine triphosphate (ATP), monosodium urate, and high mobility group box-1...
July 2018: Tohoku Journal of Experimental Medicine
Kento Morozumi, Keiko Ainoya, Jun Takemoto, Kiyohide Sakai
Campomelic dysplasia (CD) is a skeletal dysplasia characterized by shortened and bowed long bones, airway instability, the potential for disorders of sexual differentiation (DSD), and Pierre Robin Sequence (PRS) with cleft palate, midface hypoplasia and laryngotrachemomalacia. CD is caused by alterations in the Sex-determining region of the Y chromosome (SRY)-related-box 9 (SOX9), which has important roles in tissue and sexual differentiation. The SOX9 gene and the enhancer regions of SOX9 are located at chromosome 17q24...
July 2018: Tohoku Journal of Experimental Medicine
Eiko Onishi, Mamoru Murakami, Ryo Nishino, Ruri Ohba, Masanori Yamauchi
Thoracic epidural anesthesia (TEA) and paravertebral block (PVB) have been performed for perioperative regional anesthesia in the trunk. However, TEA and PVB are associated with a risk of serious complications, such as pneumothorax, hypotension, or nerve damage. Retrolaminar paravertebral block (RLB) was introduced as a new alternative to PVB. This new approach might lower the risk of serious complications, but its use has not been well established yet. Therefore, we conducted a double-masked, placebo-controlled, randomized clinical trial to evaluate the efficacy of a double-level RLB for postoperative analgesia after breast cancer surgery...
July 2018: Tohoku Journal of Experimental Medicine
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