Shiji Zhang, Na Zhao, Suli Song, Yanchun Wang, Yan Wang, Chengbiao Sun, Mingxin Dong, Mengqi Huo, Na Xu, Wensen Liu, Guorui Li
Ricin (ricin toxin, RT) has the potential to cause damage to multiple organs and systems. Currently, there are no existing antidotes, vaccinations, or effective therapies to prevent or treat RT intoxication. Apart from halting protein synthesis, RT also induces oxidative stress, inflammation and autophagy. To explore the mechanisms of RT-induced inflammatory injury and specific targets of prevention and treatment for RT poisoning, we characterized the role of cross-talk between autophagy and NLRP3 inflammasome in RT-induced damage and elucidated the underlying mechanisms...
March 14, 2024: Toxicology and Applied Pharmacology