Read by QxMD icon Read

Toxicology and Applied Pharmacology

Guolin Zhao, Muhanad Elhafiz, Jingwei Jiang, Debanjan Das, Zhijian Li, Wang Zhou, Sisi Fan, Changling Wang, Ziqiao Yuan, Dengqiu Xu, Zhenzhou Jiang, Luyong Zhang, Tao Wang
8-methoxypsoralen (8-MOP) with ultraviolet A radiation therapy (PUVA) is the standard therapy for patients with psoriasis, despite the reported potential risks of 8-MOP-induced cholestatic liver injury in both humans and animals. Usually, patients with chronic cholestasis exhibit lower serum 25-hydroxy vitamin D (25(OH)D) levels. But those patients receiving PUVA for psoriasis showed an increase in serum 25(OH)D levels, probably highlighting that the vitamin D-vitamin D nuclear receptor (VD-VDR) axis play a protective role in 8-MOP-induced hepatotoxicity...
November 9, 2018: Toxicology and Applied Pharmacology
Jinxiu Li, Shang Wang, Ling Yao, Peng Ma, Zhiwei Chen, Ting-Li Han, Chunlin Yuan, Jun Zhang, Lirong Jiang, Li Liu, Dazhi Ke, Chunli Li, Johji Yamahara, Yuhao Li, Jianwei Wang
The prevalence of NAFLD increases with age. As the main active ingredient of ginger, 6-gingerol significantly improves lipid metabolism abnormalities in adult rodents. However, few studies have reported its effect on age-related NAFLD. This study was to investigate the effects of 6-gingerol on age-related hepatic steatosis and its potential targets. As expected, 6-gingerol dramatically normalized the hepatic triglyceride content, plasma insulin and HOMA-IR index of ageing rats. Mechanistically, 6-gingerol affected lipid metabolism by increasing β-oxidation and decreasing lipogenesis through activation of PPARα and CPT1α and inhibition of DGAT-2...
November 5, 2018: Toxicology and Applied Pharmacology
Sara Ranjbar, Ruthiros Khonkarn, Alexis Moreno, Hélène Baubichon-Cortay, Ramin Miri, Mehdi Khoshneviszadeh, Luciano Saso, Najmeh Edraki, Pierre Falson, Omidreza Firuzi
Multidrug resistance (MDR) in cancer cells is often associated with overexpression of ATP-binding cassette (ABC) transporters, including P-glycoprotein (P-gp/ABCB1), multidrug resistance-associated protein 1 (MRP1/ABCC1) and breast cancer resistance protein (BCRP/ABCG2). Modulators of these transporters might be helpful in overcoming MDR. Moreover, exploiting collateral sensitivity (CS) could be another approach for efficient treatment of cancer. Twelve novel 5-oxo-hexahydroquinoline derivatives bearing different aromatic substitutions at C4 , while having 2-pyridyl alkyl carboxylate substituents at the C3 were synthesized and evaluated for MDR reversal activity by flow cytometric determination of rhodamine 123, calcein and mitoxantrone accumulations in P-gp, MRP1 and BCRP-overexpressing cell lines, respectively...
November 1, 2018: Toxicology and Applied Pharmacology
Liu Yang, Faping Xing, Xinyan Han, Qi Li, Hui Wu, Hailian Shi, Zhifei Wang, Fei Huang, Xiaojun Wu
CD4+ T cells, especially T-helper (Th) cells (Th1, Th2 and Th17) and regulatory T cells (Treg) play pivotal role in the pathogenesis of multiple sclerosis (MS), a demyelinating autoimmune disease occurring in central nervous system (CNS). Astragaloside IV (ASI, CAS: 84687-43-4) is one of the saponins isolated from Astragalus membranceus, a traditional Chinese medicine with immunomodulatory effect. So far, whether ASI has curative effect on experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and how it affects the subsets of CD4+ T cells, as well as the underlying mechanism have not been clearly elucidated...
October 29, 2018: Toxicology and Applied Pharmacology
Arthur M Langer, Robert P Nolan
The acceptance of primary tumors arising on the serosal surface of body cavities and its association with asbestos exposure was established in 1960. Epidemiological studies followed in an effort to determine if all asbestos fiber types produced the same malignancy and with the same mortality incidence. Three asbestos mortality studies were published in 1979 authored by the same research team from the Mount Sinai School of Medicine. The studies followed the same design making their datasets internally consistent and uniquely comparable...
October 28, 2018: Toxicology and Applied Pharmacology
Shimaa Elshazly, Eman Soliman
Remote organ damage is the major cause of death in patients with acute kidney injury (AKI) due to renal ischemia reperfusion (IR). Liver is one of the vital organs which are profoundly affected by AKI. The present study aims to investigate the role of peroxisome proliferator activator receptor gamma (PPARγ) in liver damage induced by IR injury in rats. Renal IR was induced by right nephrectomy, occlusion of left renal pedicle for 45 min to induce ischemia, and then reperfusion for 6 or 24 h. The PPARγ agonist, pioglitazone, was given orally for 7 days before renal IR procedure...
October 26, 2018: Toxicology and Applied Pharmacology
Lana Shaya, Devon E Jones, Joanna Y Wilson
Cytochrome P450 (CYPs) enzymes are critical for the metabolism of exogenous and endogenous compounds. In mammals, the CYP3s are arguably the most important xenobiotic metabolizing enzymes and are all contained within the CYP3A subfamily. In fish, CYP3s include CYP3A and multiple subfamilies unique to the teleost lineage. The goal of this study was to provide insight on the regulation of genes in the CYP3C subfamily. Zebrafish, which have 4 CYP3C genes, were exposed to 17β-estradiol (E2 ; 0.001-10 μM) or β-naphthoflavone (βNF; 0...
October 25, 2018: Toxicology and Applied Pharmacology
Timur O Khaliullin, Elena R Kisin, Naveena Yanamala, Supraja Guppi, Martin Harper, Taekhee Lee, Anna A Shvedova
Calcium carbonate rock dust (RD) is used in mining to reduce the explosivity of aerosolized coal. During the dusting procedures, potential for human exposure occurs, raising health concerns. To improve RD aerosolization, several types of anti-caking surface treatments exist. The aim of the study was to evaluate cytotoxicity of four respirable RD samples: untreated/treated limestone (UL/TL), untreated/treated marble (UM/TM), and crystalline silica (SiO2 ) as a positive control in A549 and THP-1 transformed human cell lines...
October 25, 2018: Toxicology and Applied Pharmacology
F D Pooley
The physical characterisation of retained EMPS is extremely important in providing information regarding the aetiology of the disease they may produce. It is now accepted that the biological effects fibres may produce in lung tissue once deposited are closely related to their concentration but more critically to their variation in length and diameter. To assess the disease risk of exposure to EMPs it is necessary to accurately describe their lengths and diameter distribution. Microscopic examination of lung burden and respirable airborne dust samples of EMPs are therefore among the most important investigations necessary to assess the risks of exposure to EMPs and provide an understanding of the manner in which they can produce a disease response...
October 24, 2018: Toxicology and Applied Pharmacology
Ju-Ying Tsai, Shin-Han Tsai, Chin-Chung Wu
The capacity of cancer cells to resist detachment-induced apoptosis, i.e. anoikis, as well as anchorage-independent growth are crucial prerequisites for tumor metastasis. Therefore, agents interfering these properties may provide novel anti-metastatic strategies. Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known as a potent chemopreventive agent, but its effect on anoikis resistance has not been investigated. In this study, two non-small cell lung cancer (NSCLC) cell lines, A549 and CL1-5 cells, were treated with SFN under either suspension or adhesion conditions...
October 24, 2018: Toxicology and Applied Pharmacology
Qiaozhu Tan, Ming Zhang, Lujing Geng, Zhenghua Xia, Cen Li, Muhammad Usman, Yuzhi Du, Lixin Wei, Hongtao Bi
Methylmercury (MeHg+ ) is an extremely toxic organomercury cation that can induce severe neurological damage. Once it enters the body, methylmercury binds to amino acids or proteins containing free sulfhydryl groups. In particular, methylmercury is known to bind with human serum albumin (HSA) in human plasma; however, the effects of methylmercury-HSA conjugate (MeHg-HSA) on the central nervous system (CNS) are not fully understood. In the present study, we used the microglial cell line N9 as the target cells to evaluate the effect of MeHg-HSA on physiological function of the CNS preliminarily...
October 22, 2018: Toxicology and Applied Pharmacology
Marko Vasić, Tatjana Lončar-Turukalo, Tatjana Tasić, Marija Matić, Sofija Glumac, Dragana Bajić, Branka Popović, Nina Japundžić-Žigon
Using comprehensive analysis of heart rate (HRV) and blood pressure (BPV) short-term variability we estimated the time course of changes of autonomic nervous system remodeling in two stages of doxorubicin-induced cardiomyopathy (DCM). We also investigated the level of gene expression of cardiac β-1 (β-1AR) and β-2 (β-2AR) adrenoceptors. Experiments were performed in adult male Wistar rats equipped with indwelling catheters for BP recording and blood withdrawal. A 15 mg/kg total cumulative dose of doxorubicin was injected i...
October 18, 2018: Toxicology and Applied Pharmacology
Xiangrong Geng, Liu Liu, Kan-Jen Tsai, Zijuan Liu
ZIP8 is a membrane transporter that facilitates the uptake of divalent metals (e.g., Zn, Mn, Fe, Cd) and the mineral selenite in anionic form. ZIP8 functionality has been recently reported to regulate cell proliferation, migration and cytoskeleton arrangement, exhibiting an essential role for normal physiology. In this study, we report a ZIP8 role in chemotherapy response. We show ZIP8 regulates cell sensitivity to the anti-cancer drug cisplatin. Overexpression of ZIP8 in mouse embryonic fibroblast (MEF) cells induces cisplatin sensitivity, while knockout of ZIP8 in leukemia HAP1 cells leads to cisplatin resistance...
October 17, 2018: Toxicology and Applied Pharmacology
Fan Wang, Ruiling Wang, Fei Liu, Wanguang Chen
Triclosan (TCS) is a broad-spectrum antibacterial agent and has been widely used in a diversity of personal care products. However, recent studies suggest that TCS has some adverse effects, and some evidences suggest in vitro neurotoxicity and developmental neurotoxicity of embryos. There are currently few studies concerning the mechanisms of TCS induced late developmental neurotoxic effect. Therefore, we investigated effects of juvenile zebrafish (Danio rerio) exposure to TCS. Male juvenile zebrafish were exposed to 68...
October 16, 2018: Toxicology and Applied Pharmacology
Yanrong Zhu, Ke Wang, Zhiqiang Ma, Dong Liu, Yang Yang, Meng Sun, Aidong Wen, Yuewen Hao, Shanbo Ma, Fang Ren, Zhenlong Xin, Yue Li, Shouyin Di, Juntian Liu
Sepsis-induced brain injury is frequently encountered in critically ill patients with severe systemic infection. Butein (3,4,2',4'-tetrahydroxychalcone) has been demonstrated as the neuro-protective agent via reducing inflammation and oxidative stress on neurons. Moreover, activation of silent information regulator 1 (SIRT1) inhibits apoptosis, oxidation and inflammation thus alleviating sepsis-induced multiorgan injuries. In present study, we show that butein administrated intraperitoneally (10 mg/kg) saved mice from sepsis-induced lethality by increasing 7-day survival rate after cecal ligation and puncture (CLP) surgery...
October 15, 2018: Toxicology and Applied Pharmacology
Gangduo Wang, Huaxian Ma, Jianling Wang, M Firoze Khan
Trichloroethene (TCE), a common environmental toxicant and widely used industrial solvent, has been implicated in the development of various autoimmune diseases (ADs). Although oxidative stress has been involved in TCE-mediated autoimmunity, the molecular mechanisms remain to be fully elucidated. These studies were, therefore, aimed to further explore the contribution of oxidative stress to TCE-mediated autoimmune response by specifically assessing the role of oxidative DNA damage, its repair enzyme poly(ADP-ribose)polymerase-1 (PARP-1) and apoptosis...
October 10, 2018: Toxicology and Applied Pharmacology
Hongxue Shi, Jian Jan, Josiah E Hardesty, K Cameron Falkner, Russell A Prough, Appakalai N Balamurugan, Sri Prakash Mokshagundam, Suresh T Chari, Matthew C Cave
The endocrine disrupting chemicals, polychlorinated biphenyls (PCBs), have been associated with nonalcoholic steatohepatitis (NASH) and diabetes. However, an integrative analysis of the effects of PCBs on the liver and pancreas has never been performed for the two major PCB subtypes, dioxin-like (DL) and nondioxin-like (NDL), and a mixture of NDL/DL PCBs. Therefore, male C57BL/6 J mice fed a control synthetic diet were treated with either a NDL PCB mixture, Aroclor 1260 (20 mg/kg); a single DL PCB congener, PCB 126 (20 μg/kg); a NDL/DL mixture, Aroclor 1260 plus PCB 126; or vehicle control for 2 weeks...
October 9, 2018: Toxicology and Applied Pharmacology
Sunwoo Park, Whasun Lim, Gwonhwa Song
Breast cancer is a leading lethal gynecological cancer. Although many tumor markers and target genes have been studied in breast cancer, its incidence is increasing. Recently, the therapeutic effects of natural phytochemicals have been studied in various cancers as adjuvants. Chrysophanol is an anti-inflammatory, anti-angiogenetic, and anti-tumor anthraquinone but has not been widely studied in cancers. Here, we verified the anti-cancer effects and cellular mechanism of chrysophanol in human breast cancer cells (BT-474 and MCF-7)...
October 6, 2018: Toxicology and Applied Pharmacology
Ana D Martins, Mariana P Monteiro, Branca M Silva, Alberto Barros, Mário Sousa, Rui A Carvalho, Pedro F Oliveira, Marco G Alves
Obesity incidence has pandemic proportions and is expected to increase even further. Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological resources for obesity treatment. GLP-1 regulates energy and glucose homeostasis, which are also crucial for spermatogenesis. Herein, we studied the GLP-1 effects in human Sertoli cells (hSCs) metabolism and mitochondrial function. hSCs were cultured in absence or exposed to increasing doses of GLP-1 mimicking physiological post-prandial (0...
October 6, 2018: Toxicology and Applied Pharmacology
Moisés Hamoy, Luiz Dos Santos Batista, Vanessa Joia de Mello, Walace Gomes-Leal, Rômulo Augusto Feio Farias, Pedro Dos Santos Batista, José Luiz Martins do Nascimento, Helcio Casemiro Marcondes, Jason G Taylor, William D Hutchison, Marcelo Ferreira Torres, Luis André L Barbas
This study aimed at describing the characteristics and properties of seizures induced by cunaniol, a polyacetylenic alcohol isolated from the Clibadium genus, which is ubiquitous in the Amazon biodiversity and its potential use as a convulsant model. Wistar rat behavior was assessed upon cunaniol administration and animals were evaluated for neural activity through electroencephalographic records whereby epidural electrodes were positioned over the motor cortex under cunaniol-elicited seizures and seizure's control using three anticonvulsant agents, namely phenytoin, phenobarbital and diazepam...
October 5, 2018: Toxicology and Applied Pharmacology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"