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Yonsei Medical Journal

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https://www.readbyqxmd.com/read/29214795/retraction-paper-comparison-of-the-effect-of-vitamin-k2-and-risedronate-on-trabecular-bone-in-glucocorticoid-treated-rats-a-bone-histomorphometry-study-by-iwamoto-j-et-al-yonsei-med-j-2009-50-2-189-194
#1
https://www.readbyqxmd.com/read/29214794/retraction-paper-comparison-of-effects-of-alendronate-and-raloxifene-on-lumbar-bone-mineral-density-bone-turnover-and-lipid-metabolism-in-elderly-women-with-osteoporosis-by-iwamoto-j-et-al-yonsei-med-j-2008-49-1-119-128
#2
https://www.readbyqxmd.com/read/29214793/mesocaval-shunt-creation-for-jejunal-variceal-bleeding-with-chronic-portal-vein-thrombosis
#3
Ja Kyung Yoon, Man Deuk Kim, Do Yun Lee, Seok Joo Han
The creation of transjugular intrahepatic portosystemic shunt (TIPS) is a widely performed technique to relieve portal hypertension, and to manage recurrent variceal bleeding and refractory ascites in patients where medical and/or endoscopic treatments have failed. However, portosystemic shunt creation can be challenging in the presence of chronic portal vein occlusion. In this case report, we describe a minimally invasive endovascular mesocaval shunt creation with transsplenic approach for the management of recurrent variceal bleeding in a portal hypertension patient with intra- and extrahepatic portal vein occlusion...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214792/life-threatening-thrombocytopenia-following-intravenous-contrast-media-infusion
#4
Mihwa Park, Minjeong Kim, Jisun Park, Jinhyun Cho
Radiocontrast media-induced acute severe thrombocytopenia is a very rare complication and potentially life-threatening. Here, we report the case of a 63-year-old male patient with severe acute thrombocytopenia following first exposure to intravenous non-ionic contrast media without immediate allergic reactions. His platelet count dropped from 107000/μL to 2000/μL after six hours of radiocontrast infusion. After administration of corticosteroid and transfusion of platelet concentrates, the platelet count returned gradually to normal within 5 days...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214791/a-case-of-schnitzler-s-syndrome-without-monoclonal-gammopathy-associated-chronic-urticaria-treated-with-anakinra
#5
Min Joo Ahn, Ji Eun Yu, Jiung Jeong, Da Woon Sim, Young Il Koh
Chronic urticaria may often be associated with interleukin (IL)-1-mediated autoinflammatory disease, which should be suspected if systemic inflammation signs are present. Here, we report a case of Schnitzler's syndrome without monoclonal gammopathy treated successfully with the IL-1 receptor antagonist anakinra. A 69-year-old man suffered from a pruritic urticarial rash for 12 years. It became aggravated episodically and was accompanied by high fever, arthralgia, leukocytosis, and an elevated C-reactive protein and erythrocyte sedimentation rate...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214790/variants-of-lipolysis-related-genes-in-korean-patients-with-very-high-triglycerides
#6
Chan Joo Lee, Chi Yoon Oum, Yunbeom Lee, Sungha Park, Seok Min Kang, Donghoon Choi, Yangsoo Jang, Ji Hyun Lee, Sang Hak Lee
We investigated the prevalence and characteristics of variants of five lipolysis-related genes in Korean patients with very high triglycerides (TGs). Twenty-six patients with TG levels >885 mg/dL were selected from 13545 Korean subjects. Five candidate genes, LPL, APOC2, GPIHBP1, APOA5, and LMF1, were sequenced by targeted next-generation sequencing. Predictions of functional effects were performed and matched against public databases of variants. Ten rare variants of three genes were found in nine (34.6%) patients (three in LPL, four in APOA5, and three in LMF1)...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214789/microrna-183-is-essential-for-hair-cell-regeneration-after-neomycin-injury-in-zebrafish
#7
Chang Woo Kim, Ji Hyuk Han, Ling Wu, Jae Young Choi
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the present study, we show that the microRNA (miR)-183 cluster is upregulated during hair cell regeneration and that its inhibition reduces hair cell regeneration following neomycin-induced ototoxicity in zebrafish. MATERIALS AND METHODS: miRNA expression patterns after neomycin exposure were analyzed using microarray chips...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214788/asymmetry-of-peak-thicknesses-between-the-superior-and-inferior-retinal-nerve-fiber-layers-for-early-glaucoma-detection-a-simple-screening-method
#8
Hyoung Won Bae, Sang Yeop Lee, Sangah Kim, Chan Keum Park, Kwanghyun Lee, Chan Yun Kim, Gong Je Seong
PURPOSE: To assess whether the asymmetry in the peripapillary retinal nerve fiber layer (pRNFL) thickness between superior and inferior hemispheres on optical coherence tomography (OCT) is useful for early detection of glaucoma. MATERIALS AND METHODS: The patient population consisted of Training set (a total of 60 subjects with early glaucoma and 59 normal subjects) and Validation set (30 subjects with early glaucoma and 30 normal subjects). Two kinds of ratios were employed to measure the asymmetry between the superior and inferior pRNFL thickness using OCT...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214787/myocardial-layer-specific-strain-analysis-in-children-with-mitochondrial-disease
#9
Lucy Youngmin Eun, Young Mock Lee
PURPOSE: Children with mitochondrial disease (MD) have clinical phenotypes that are more severe than those found in adults. In this study, we assessed cardiac function in children with MD using conventional and advanced echocardiographic measurements, explored any unique patterns present, and investigated the development of early cardiomyopathy (CMP). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 33 children with MD. All patients underwent transthoracic echocardiography with conventional and advanced myocardial analysis...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214786/itpkc-and-slc11a1-gene-polymorphisms-and-gene-gene-interactions-in-korean-patients-with-kawasaki-disease
#10
Kyu Yeun Kim, Yoon Sun Bae, Woohyuk Ji, Dongjik Shin, Ho Seong Kim, Dong Soo Kim
PURPOSE: Kawasaki disease (KD) is an acute systemic vasculitis. Both the etiology of KD and the erythema of Bacille Calmette-Guérin (BCG) injection sites observed in the disease are poorly understood. We investigated the association between KD and single nucleotide polymorphisms (SNPs) in two candidate genes: inositol 1,4,5-triphosphate 3-kinase (ITPKC), a well-studied KD-associated gene, and solute carrier 11a1 (SLC11A1), which is associated with the hypersensitive reaction to the BCG strain in Koreans...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214785/clinical-outcomes-of-low-dose-methotrexate-therapy-as-a-second-line-drug-for-intravenous-immunoglobulin-resistant-kawasaki-disease
#11
Hyejin Jang, Kyu Yeun Kim, Dong Soo Kim
PURPOSE: Intravenous immunoglobulin (IVIG) is the standard treatment for Kawasaki disease (KD). However, there is still no standard treatment for IVIG-resistant KD. This study aimed to evaluate the efficacy of low-dose methotrexate (MTX) as a treatment for IVIG-resistant KD. MATERIALS AND METHODS: We retrospectively analyzed 10-year data for patients with IVIG-resistant KD who were administered MTX at Severance Children's Hospital. RESULTS: The subjects included 75 patients with KD aged 5 months to 9...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214784/contrast-induced-acute-kidney-injury-after-coil-embolization-for-aneurysmal-subarachnoid-hemorrhage
#12
Hyun Goo Lee, Won Ki Kim, Je Young Yeon, Jong Soo Kim, Keon Ha Kim, Pyoung Jeon, Seung Chyul Hong
PURPOSE: Contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes after percutaneous coronary intervention. However, CI-AKI has rarely been evaluated within the neurovascular field. The aim of this study was to investigate the incidence and clinical implication of CI-AKI after coil embolization in patients with an aneurysmal subarachnoid hemorrhage (aSAH). MATERIALS AND METHODS: Between January 2005 and March 2016, 192 patients who underwent coil embolization were enrolled in this study...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214783/effective-tidal-volume-for-normocapnia-in-very-low-birth-weight-infants-using-high-frequency-oscillatory-ventilation
#13
Seul Mi Lee, Ran Namgung, Ho Sun Eun, Soon Min Lee, Min Soo Park, Kook In Park
PURPOSE: Removal of CO₂ is much efficient during high-frequency oscillatory ventilation (HFOV) for preterm infants. However, an optimal carbon dioxide diffusion coefficient (DCO₂) and tidal volume (VT) have not yet been established due to much individual variance. This study aimed to analyze DCO₂ values, VT, and minute volume in very-low-birth-weight (VLBW) infants using HFOV and correlates with plasma CO₂ (pCO₂). MATERIALS AND METHODS: Daily respiratory mechanics and ventilator settings from twenty VLBW infants and their two hundred seventeen results of blood gas analysis were collected...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214782/effect-of-family-history-of-diabetes-on-hemoglobin-a1c-levels-among-individuals-with-and-without-diabetes-the-dong-gu-study
#14
Young Hoon Lee, Min Ho Shin, Hae Sung Nam, Kyeong Soo Park, Seong Woo Choi, So Yeon Ryu, Sun Seog Kweon
PURPOSE: We investigated associations between family history of diabetes (FHD) and hemoglobin A1c (HbA1c) level, among people with and without diabetes. MATERIALS AND METHODS: In total, 7031 people without diabetes and 1918 people with diabetes who participated in the Dong-gu Study were included. Data on FHD in first-degree relatives (father, mother, and siblings) were obtained. Elevated HbA1c levels in people without diabetes and high HbA1c levels in people with diabetes were defined as the highest quintiles of HbA1c ≥5...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214781/adipogenic-and-lipolytic-effects-of-ascorbic-acid-in-ovariectomized-rats
#15
Byoungjae Kim, Kyung Min Choi, Hong Soon Yim, Hyun Tae Park, Joung Han Yim, Min Goo Lee
PURPOSE: Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we tested the effects of ascorbic acid on adipogenesis and the balance of lipid accumulation in ovariectomized rats, in addition to long-term culture of differentiated 3T3-L1 adipocytes. MATERIALS AND METHODS: Murine 3T3-L1 fibroblasts and ovariectomized rats were treated with ascorbic acid at various time points...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214780/mismatch-between-tof-mr-angiography-and-ct-angiography-of-the-middle-cerebral-artery-may-be-a-critical-sign-in-cerebrovascular-dynamics
#16
Keiji Igase, Michiya Igase, Ichiro Matsubara, Kazuhiko Sadamoto
PURPOSE: Although time-of-flight (TOF)-magnetic resonance angiography (MRA) can clearly depict intracranial arteries, the arterial flow of middle cerebral artery (MCA) is occasionally not detected. We evaluated this phenomenon with reference to cerebrovascular dynamics. MATERIALS AND METHODS: Seventeen patients with suspected occlusion of MCA or internal carotid artery on TOF-MRA were enrolled. All patients underwent CT angiography (CTA) and quantitative cerebral blood flow (CBF) examination for measurement of resting CBF and cerebrovascular reactivity (CVR)...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214779/effectiveness-and-safety-of-biolimus-a9%C3%A2-eluting-stent-in-patients-with-acute-coronary-syndrome-a-multicenter-observational-study-beauty-study
#17
Keun Ho Park, Myung Ho Jeong, Young Joon Hong, Youngkeun Ahn, Hyun Kuk Kim, Young Yub Koh, Doo Il Kim, Sang Wook Kim, Weon Kim, Seung Woon Rha, Jay Young Rhew, Jong Seon Park, Hun Sik Park, Jang Ho Bae, Jang Whan Bae, Seok Kyu Oh, Sung Yun Lee, Seung Wook Lee, Jae Hwan Lee, Sang Yeob Lim, Jang Hyun Cho, Kwang Soo Cha, Jai Keon Chae, Seung Ho Hur, Sun Ho Hwang, Jin Yong Hwang
PURPOSE: This study sought to determine the 1-year clinical effectiveness and safety of a biodegradable, polymer-containing Biolimus A9™-eluting stent (BES) in Korean patients with acute coronary syndrome (ACS). MATERIALS AND METHODS: A total of 1000 ACS patients with 1251 lesions who underwent implantation of BESs at 22 centers in Korea were enrolled between May 2011 and July 2013. We assessed major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinical-driven target vessel revascularization at 12 months...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214778/supplementary-diagnostic-landmarks-of-left-ventricular-non-compaction-on-magnetic-resonance-imaging
#18
Marko Boban, Vladimir Pesa, Natko Beck, Sime Manola, Marinko Zulj, Ante Rotim, Aleksandar Vcev
PURPOSE: Diagnostic criteria for left ventricular non-compaction (LVNC) are still a matter of dispute. The aim of our present study was to test the diagnostic value of two novel diagnostic cardiac magnetic resonance (CMR) parameters: proof of non-compact (NC) myocardium blood flow using T2 sequences and changes in geometry of the left ventricle. MATERIALS AND METHODS: The study included cases with LVNC and controls, from a data base formed in a period of 3.5 years (n=1890 exams), in which CMR protocol included T2 sequences...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214777/is-there-a-sex-related-difference-in-the-obesity-paradox-in-systolic-heart-failure-sex-related-difference-in-the-obesity-paradox
#19
Soonchang Hong, Ji Hyun Lee, Kyung Min Kim, Jun Won Lee, Young Jin Youn, Min Soo Ahn, Sung Gyun Ahn, Seung Hwan Lee, Junghan Yoon, Kyung Hoon Choe, Byung Su Yoo
PURPOSE: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. MATERIALS AND METHODS: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214776/14-3-3%C3%AE-overexpression-is-associated-with-poor-prognosis-in-ovarian-cancer
#20
Hyun Jung Kim, Sun Hee Sung, Chan Young Kim, Moon Kyoung Bae, Min Sun Cho, Yun Hwan Kim, Seung Cheol Kim, Woong Ju
PURPOSE: 14-3-3ζregulates cell signaling, cell cycle progression, and apoptosis, and its overexpression is associated with disease recurrence and poor clinical outcomes in some solid tumors. However, its clinicopathological role in ovarian cancer is unknown. Our goal was to investigate whether 14-3-3ζis associated with ovarian cancer prognosis. MATERIALS AND METHODS: We examined 14-3-3ζexpression by immunohistochemistry in ovarian cancer tissues obtained from 88 ovarian cancer patients...
January 2018: Yonsei Medical Journal
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