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Yonsei Medical Journal

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https://www.readbyqxmd.com/read/29749140/increased-uptake-of-av-1451-in-a-subacute-infarction-lesion
#1
Soo Hyun Cho, Hanna Cho, Seongbeom Park, Young Hoon Ryu, Jae Yong Choi, Chul Hyoung Lyoo, Duk L Na, Sang Won Seo, Hee Jin Kim
¹⁸F-AV-1451 is a tau PET ligand that has high affinity for paired helical filament tau. However, various off-target bindings unrelated to tau have also been reported. Herein, we report a case of 83-year-old woman, who showed abnormal uptake of AV-1451 that was shown to be subacute infarction. Clinicians should recognize that increased uptake of AV-1451 may be related to stroke.
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749139/physical-inactivity-and-unhealthy-metabolic-status-are-associated-with-decreased-natural-killer-cell-activity
#2
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Jae Myun Lee, Tae Il Kim
PURPOSE: Several studies have reported relationships among physical activity, healthy metabolic status, and increased natural killer (NK) cell activity. However, large-scale data thereon are lacking. Thus, the present study aimed to assess NK cell activity according to physical activity and metabolic status. MATERIALS AND METHODS: A cross-sectional study was performed on 12014 asymptomatic examinees. Using a patented stimulatory cytokine, NK cell activity was quantitated by the amount of interferon-γ secreted into the plasma by NK cells...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749138/estimation-of-standard-liver-volume-using-ct-volume-body-composition-and-abdominal-geometry-measurements
#3
Xiaopeng Yang, Jae Do Yang, Seunghoon Lee, Hong Pil Hwang, Sungwoo Ahn, Hee Chul Yu, Heecheon You
PURPOSE: The present study developed formulas for estimation of standard liver volume (SLV) with high accuracy for the Korean population. MATERIALS AND METHODS: SLV estimation formulas were established using gender-balanced and gender-unbalanced measurements of anthropometric variables, body composition variables, and abdominal geometry of healthy Koreans (n=790). Total liver volume excluding blood volume, was measured based on CT volumetry. RESULTS: SLV estimation formulas as preferred in various conditions of data availability were suggested in the present study...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749137/the-effect-of-diagnosis-related-group-payment-system-on-quality-of-care-in-the-field-of-obstetrics-and-gynecology-among-korean-tertiary-hospitals
#4
Yong Wook Jung, Haeyong Pak, Inha Lee, Eui Hyeok Kim
PURPOSE: To examine changes in clinical practice patterns following the introduction of diagnosis-related groups (DRGs) under the fee-for-service payment system in July 2013 among Korean tertiary hospitals and to evaluate its effect on the quality of hospital care. MATERIALS AND METHODS: Using the 2012-2014 administrative database from National Health Insurance Service claim data, we reviewed medical information for 160400 patients who underwent cesarean sections (C-secs), hysterectomies, or adnexectomies at 43 tertiary hospitals...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749136/minimally-invasive-lumbar-spinal-fusion-is-more-effective-than-open-fusion-a-meta-analysis
#5
Yung Park, Sang Ok Seok, Soo Bin Lee, Joong Won Ha
PURPOSE: To evaluate the efficacy of minimally invasive spinal fusion in comparison to open fusion for adult lumbar spondylolisthesis or spondylosis. MATERIALS AND METHODS: The present study was conducted as a meta-analysis of all estimates from studies that were selected after comprehensive literature search by two independent reviewers. RESULTS: Of 745 articles, nine prospective cohort studies were identifed. The quality of evidence was downgraded because of study design, inconsistency, imprecision, and publication bias...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749135/variants-in-the-gene-ebf2-are-associated-with-kawasaki-disease-in-a-korean-population
#6
Yoonsun Bae, Dongjik Shin, Jiho Nam, Hye Rim Lee, Jun Sung Kim, Kyu Yeun Kim, Dong Soo Kim, Yeun Jun Chung
PURPOSE: Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. MATERIALS AND METHODS: An SNP analysis was performed by whole exon sequencing of the EBF2 gene...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749134/mir-215-enhances-hcv-replication-by-targeting-trim22-and-inactivating-nf-%C3%AE%C2%BAb-signaling
#7
Hui Tian, Zhenkun He
PURPOSE: Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associated with HCV infection. This study aimed to investigate the functional roles and possible molecular mechanisms of miR-215 in HCV replication. MATERIALS AND METHODS: The expression levels of miR-215 and TRIM22 were detected by quantitative real-time PCR (qRT-PCR) and western blot analysis in Con1b subgenomic genotype 1b HCV replicon cells (Con1b cells) and JFH1 full genome infecting Huh7...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749133/characteristics-of-adrenal-incidentalomas-in-a-large-prospective-computed-tomography-based-multicenter-study-the-coar-study-in-korea
#8
Seong Hee Ahn, Jae Hyeon Kim, Seung Hee Baek, Hyeonmok Kim, Yoon Young Cho, Sunghwan Suh, Beom Jun Kim, Seongbin Hong, Jung Min Koh, Seung Hun Lee, Kee Ho Song
PURPOSE: Previous studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients, Western populations, or use of an outdated imaging technique. We investigated the characteristics of AIs in Korean patients and compared them with those reported in the largest retrospective study in Italy to discover the effects of improved imaging techniques and ethnicity differences. MATERIALS AND METHODS: This was a prospective, multicenter, cross-sectional observational study including 1005 Korean patients...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749132/prognostic-value-of-micrornas-in-coronary-artery-diseases-a-meta-analysis
#9
Ji Suk Kim, Kyoungjune Pak, Tae Sik Goh, Dae Cheon Jeong, Myoung Eun Han, Jihyun Kim, Sae Ock Oh, Chi Dae Kim, Yun Hak Kim
PURPOSE: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749131/the-impact-of-prediabetes-on-two-year-clinical-outcomes-in-patients-undergoing-elective-percutaneous-coronary-intervention
#10
Woong Gil Choi, Seung Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo
PURPOSE: Prediabetes is an independent risk factor for cardiovascular disease. However, data on the long term adverse clinical outcomes of prediabetic patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) are scarce. MATERIALS AND METHODS: The study population comprised 674 consecutive non-diabetic patients who underwent elective PCI between April 2007 and November 2010. Prediabetes was defined as hemoglobin A1c (HbA1c) of 5...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749130/effects-of-coronary-artery-revascularization-with-a-polymer-free-biolimus-a9-coated-biofreedom-stent-versus-bypass-surgery-before-noncardiac-surgery
#11
Kyu Kim, Choongki Kim, Byeong Keuk Kim, Ji Yong Jang, Ae Young Her, Seunghwan Kim, Sung Jin Hong, Chul Min Ahn, Jung Sun Kim, Young Guk Ko, Donghoon Choi, Myeong Ki Hong, Yangsoo Jang
PURPOSE: The present study aimed to evaluate the efficacy and safety of polymer-free drug-coated BioFreedom stent implantation in comparison to coronary artery bypass graft (CABG) before major noncardiac surgery. MATERIALS AND METHODS: In a multicenter registry, 55 patients required revascularization before major noncardiac surgery that should not be delayed >6 months. Of them, 27 underwent BioFreedom stent implantation and 28 underwent CABG. Primary outcomes included rate of noncardiac surgery, time from revascularization to noncardiac surgery, and occurrence of composite outcomes (all-cause death, myocardial infarction, stent thrombosis, stroke, repeat revascularization, or major bleeding)...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749129/plasma-cell-free-dna-as-a-predictive-marker-after-radiotherapy-for-hepatocellular-carcinoma
#12
Sangjoon Park, Eun Jung Lee, Chai Hong Rim, Jinsil Seong
PURPOSE: Cell-free DNA (cfDNA) is gaining attention as a novel biomarker for oncologic outcomes. We investigated the clinical significance of cfDNA in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). MATERIALS AND METHODS: Fifty-five patients with HCC who received RT were recruited from two prospective study cohorts: one cohort of 34 patients who underwent conventionally fractionated RT and a second of 21 patients treated with stereotactic body radiation therapy...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29749128/moonlighting-activity-of-secreted-inflammation-regulatory-proteins
#13
REVIEW
Joo Heon Yoon, Junsun Ryu, Seung Joon Baek
Moonlighting proteins exhibit multiple activities in different cellular compartments, and their abnormal regulation could play an important role in many diseases. To date, many proteins have been identified with moonlighting activity, and more such proteins are being gradually identified. Among the proteins that possess moonlighting activity, several secreted proteins exhibit multiple activities in different cellular locations, such as the extracellular matrix, nucleus, and cytoplasm. While acute inflammation starts rapidly and generally disappears in a few days, chronic inflammation can last for months or years...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29611411/erratum-to-pathologic-impact-of-insulin-resistance-and-sensitivity-on-the-severity-of-liver-histopathology-in-pediatric-non-alcoholic-steatohepatitis-by-park-bh-et-al-yonsei-med-j-2017-58-756-762
#14
https://www.readbyqxmd.com/read/29611410/total-transcanal-endoscopic-facial-nerve-decompression-for-traumatic-facial-nerve-palsy
#15
Aveline Aloyce Kahinga, Ji Hyuk Han, In Seok Moon
A few approaches can be used to decompress traumatic facial nerve paralysis including the middle cranial fossa approach or transmastoid approach depending on the site of injury. In some specific situation of treating traumatic facial nerve palsy whose injured site was confined from the geniculate ganglion to the second genu, transcanal endoscopic approach for facial nerve decompression can be used. We performed two cases of total endoscopic transcanal facial nerve decompression in patients with traumatic facial nerve palsy...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29611409/safety-of-tocilizumab-in-rheumatoid-arthritis-patients-with-resolved-hepatitis-b-virus-infection-data-from-real-world-experience
#16
Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong Beom Park, Jun Yong Park, Sang Won Lee
To investigate whether the use of IL-6 receptor antagonist (tocilizumab) might be associated with hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients, particularly in those with resolved HBV infection [HBV surface antigen (HBsAg) negative and antibody to HBV core antigen (anti-HBc) positive, serologically]. HBsAg, anti-HBc, antibody to HBsAg (anti-HBs), and HBV DNA titers were measured in RA patients who had continuously received tocilizumab for more than 3 months. Patients were divided into two groups according to the presence of anti-HBc...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29611408/the-effect-of-mental-rotation-on-surgical-pathological-diagnosis
#17
Heejung Park, Hyun Soo Kim, Yoon Jin Cha, Junjeong Choi, Yangki Minn, Kyung Sik Kim, Se Hoon Kim
PURPOSE: Pathological diagnosis involves very delicate and complex consequent processing that is conducted by a pathologist. The recognition of false patterns might be an important cause of misdiagnosis in the field of surgical pathology. In this study, we evaluated the influence of visual and cognitive bias in surgical pathologic diagnosis, focusing on the influence of "mental rotation." MATERIALS AND METHODS: We designed three sets of the same images of uterine cervix biopsied specimens (original, left to right mirror images, and 180-degree rotated images), and recruited 32 pathologists to diagnose the 3 set items individually...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29611407/radiographic-and-clinical-outcomes-of-robot-assisted-posterior-pedicle-screw-fixation-two-year-results-from-a-randomized-controlled-trial
#18
Sang Min Park, Ho Joong Kim, Se Yeon Lee, Bong Soon Chang, Choon Ki Lee, Jin S Yeom
PURPOSE: We prospectively assessed the early radiographic and clinical outcomes (minimum follow-up of 2 years) of robot-assisted pedicle screw fixation (Robot-PSF) and conventional freehand pedicle screw fixation (Conv-PSF). MATERIALS AND METHODS: Patients were randomly assigned to Robot-PSF (37 patients) or Conv-PSF (41 patients) for posterior interbody fusion surgery. The Robot-PSF group underwent minimally invasive pedicle screw fixation using a pre-planned robot-guided screw trajectory...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29611406/phenotypic-analysis-of-korean-patients-with-abnormal-chromosomal-microarray-in-patients-with-unexplained-developmental-delay-intellectual-disability
#19
Hyo Jeong Kim, Chang Il Park, Jae Woo Lim, Gyung Min Lee, Eunhae Cho, Hyon J Kim
PURPOSE: The present study aimed to investigate chromosomal microarray (CMA) and clinical data in patients with unexplained developmental delay/intellectual disability (DD/ID) accompanying dysmorphism, congenital anomalies, or epilepsy. We also aimed to evaluate phenotypic clues in patients with pathogenic copy number variants (CNVs). MATERIALS AND METHODS: We collected clinical and CMA data from patients at Konyang University Hospital between September 2013 and October 2014...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29611405/vocalization-of-emotional-and-social-expressions-in-korean-speaking-toddlers-with-autism-spectrum-disorder-and-those-with-developmental-delay
#20
Kyung Sook Lee, Yee Jin Shin, Hee Jeong Yoo, Gui Jong Lee, Jeong Ryu, Oweol Son, Sook Whan Cho
PURPOSE: This study aimed to examine the development of socializing and emotional expressions through vocalizations and joint attention (JA) behaviors in Korean-speaking children with autism spectrum disorder (ASD), compared to those with developmental delay (DD). MATERIALS AND METHODS: Video samples were collected from 28 toddlers with ASD and 18 age-matched toddlers with DD, and vocalizations were each coded in detail for the purpose of this retrospective research...
May 2018: Yonsei Medical Journal
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