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Yonago Acta Medica

Suguru Shiraya, Yoshinobu Nakamura, Yoshikazu Fujiwara, Shingo Harada, Yuichiro Kishimoto, Takeshi Onohara, Yuki Otsuki, Motonobu Nishimura
One complication of an autogenous arteriovenous fistula (AVF) for hemodialysis is the formation of a venous aneurysm. The treatment of a massive aneurysmal AVF generally involves ligation or resection with the use of prosthetic interposition. We present the case of a 46-year-old man in whom an AVF aneurysm was successfully treated by placating the excess free wall of the aneurysm with sutures. This method is a simple and effective intervention for managing aneurysm-associated complications. In addition, this approach helps to maintain the benefits of autogenous access while conserving future dialysis sites...
June 2018: Yonago Acta Medica
Ryoko Kimura, Kazunari Sugita, Hiroyuki Goto, Osamu Yamamoto
We report a case of squamous cell carcinoma manifested as a cutaneous horn. A 92-year-old man was referred to our department for evaluation of a 3-month history of a keratotic cutaneous horn on the left side of his neck. The height of the cutaneous horn was larger than the diameter of erythema at the base. Histopathological examination showed a hyperkeratotic horn developing over a mass of large atypical keratinocytes with large hyperchromatic and pleomorphic nuclei. Based on these findings, a diagnosis of squamous cell carcinoma was made...
June 2018: Yonago Acta Medica
Ryoko Kimura, Kazunari Sugita, Osamu Yamamoto
We present an unusual case of cystic pilomatricoma. A 13-year-old Japanese boy was referred to our department for evaluation of a 10-day history of a small reddish nodule on his right cheek. Histopathological examination showed a well-circumscribed cystic structure showing a central empty cavity in the dermis. The wall of the cyst was composed of basophilic cells. Inner layers of the wall were covered with flattened epithelial cells having trichohyalin granules. Based on these findings, a diagnosis of cystic pilomatricoma was made...
June 2018: Yonago Acta Medica
Naruo Tokuyasu, Kohei Shomori, Kuniki Amano, Soichiro Honjo, Teruhisa Sakamoto, Joji Watanabe, Masataka Amisaki, Masaki Morimoto, Ei Uchinaka, Takuki Yagyu, Hiroaki Saito, Hisao Ito, Yoshiyuki Fujiwara
Background: Indirubin, a constituent of the Chinese herbal medicine "Qing-Dai," has anti-cancer and anti-inflammatory activities. We aimed to evaluate the efficacy of indirubin for ameliorating colonic inflammation in a mouse model of inflammatory bowel disease. Methods: Mice with dextran sulfate sodium (DSS)-induced acute and chronic colitis were treated with indirubin in their diet. Clinical and histologic changes were evaluated. In addition, colon levels of interleukin-6, a critical pro-inflammatory mediator, was detected by enzyme-linked immunosorbent assay...
June 2018: Yonago Acta Medica
Eiji Matsusue, Yoshio Fujihara, Kenichiro Tanaka, Yuki Aozasa, Manabu Shimoda, Hiroyuki Nakayasu, Kazuhiko Nakamura, Toshihide Ogawa
Background: 123 I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy and 123 I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) provide specific information that distinguish Parkinson's disease (PD) from parkinsonian syndromes other than PD (non-PD), including atypical parkinsonian disorder (APD) and non-PD other than APD (nPD-nAPD). The purpose of this study was to determine whether combining DAT-SPECT and MIBG myocardial scintigraphy using multiparametric scoring system (MSS) could improve diagnostic test accuracy in discriminating PD from APD or discriminating PD from nPD-nAPD...
June 2018: Yonago Acta Medica
Naoko Mukuda, Shinya Fujii, Chie Inoue, Takeru Fukunaga, Tetsuro Oishi, Tasuku Harada, Toshihide Ogawa
Background: We investigated the distinguishing pathological features of bilateral ovarian tumors using magnetic resonance (MR) imaging. Methods: Eighty-six patients with bilateral ovarian tumors on MR imaging were evaluated. The pathological diagnosis was investigated, and the results were subjected to statistical analysis using Mann-Whitney U test, Fisher's exact test, Chi-squared test and receiver operating characteristic (ROC) curve to determine the features useful for the differentiation of distinct types of lesions...
June 2018: Yonago Acta Medica
Satoshi Koba
In congestive heart failure (CHF), sympathetic nervous system is hyperactive. This article reviews current understandings about central and peripheral neural mechanisms underlying sympathetic hyperactivation in this pathological condition. During the development of CHF, renin-angiotensin system (RAS) activities and angiotensin II-mediated oxidative stress become enhanced. Here, on the basis of findings obtained from animal studies, it is examined how RAS overactivation and oxidative stress in central and peripheral nervous systems of CHF mediate sympathetic hyperactivation...
June 2018: Yonago Acta Medica
Koichi Kaneko
Schizophrenia is a chronic, disabling disorder, which commonly emerges in adolescence and young adulthood. While pharmacological treatment with currently available second-generation antipsychotics exerts beneficial effects on the positive symptoms of schizophrenia, they have little effect on negative symptoms or cognitive deficits. Because these two types of symptoms are enduring, and negatively impact social functioning throughout the course of the illness, there is an urgent requirement to develop new effective therapeutic approaches to manage them...
June 2018: Yonago Acta Medica
Yuki Hatayama, Satoko Matsumoto, Eiko Hamada, Nao Kojima, Ayako Hara, Norihiko Hino, Toru Motokura
Acute transfusion reactions (ATRs) are significantly relevant to the morbidity and mortality of patients. ATRs are mostly not severe and rarely cause severe conditions, including anaphylactic shock. The aim of this study was to clarify the frequency of ATRs and the time of event occurrence. A total of 18,745 transfusions were administered to 11,718 patients during a 3-year period. Adverse reactions including at least one sign or symptom were collected through a report system in 143 of 2,478 (5.7%) platelet concentrate transfusions, 105 of 6,629 (1...
March 2018: Yonago Acta Medica
Daeho Park, Kazuoki Inoue, Toshihiro Hamada, Shin-Ichi Taniguchi, Naoki Sato, Masahiko Koda
A 66-year-old man presented at our emergency department with severe intermittent abdominal pain. His history revealed that he had eaten several mochi (rice cakes) without sufficiently chewing them before swallowing. Following computed tomography that showed a high value, he was diagnosed with an obstruction caused by mochi. Although mochi obstruction can sometimes improve with conservative treatment, this case required laparotomy. Medical literature in English on small bowel obstruction due to mochi is rare, but fortunately in this case we were able to collect complete laboratory and imaging data...
March 2018: Yonago Acta Medica
Shuji Suzuki, Kazunari Sugita, Tatsushi Shiomi, Osamu Yamamoto
A case of 75-year-old woman with sebaceous epithelioma was reported. The histological features were distinct in that it had a sinusoidal and carcinoid-like growth pattern, which has been reported in its malignant counterpart. Immunostaining for adipophilin was positive in the area with lipid-laden vacuolated cells, but the rest of tumor, which had cord-like nests, was negative. MIB index was 2%. CK5/6 and p40 were positive in the cord-like nesting areas. CK7, CK20, alpha SMA, and epithelial membrane antigen were negative in both the cord-like nesting areas and the adipose-like areas...
March 2018: Yonago Acta Medica
Hiroaki Saito, Yusuke Kono, Yuki Murakami, Yuji Shishido, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara
Background: The incidence of gastric cancer (GC) among older adults is increasing. Therefore, determining postoperative age-associated prognostic factors is clinically important. This study retrospectively investigated the prognostic significance of serum albumin level in older GC patients. Methods: We enrolled 135 patients aged ≥ 75 years, who underwent gastrectomies with histopathological diagnoses of gastric adenocarcinoma. Results: Preoperative albumin (pre-Alb) levels in patients with advanced GC and stage III/IV GC were significantly lower than those in patients with early GC ( P = 0...
March 2018: Yonago Acta Medica
Tokumitsu Mihara, Shinji Tanishima, Atsushi Tanida, Ryota Teshima, Hideki Nagashima
Background: To histologically evaluate lumbar involvement in rheumatoid arthritis (RA) by investigating rats with collagen-induced arthritis (CIA) and to assess the potential effects of RA on the discovertebral joints and facet joints. Methods: Seven-month-old female Sprague-Dawley rats were divided into groups with CIA and without CIA (control). All rats were sacrificed at 8 weeks after initial sensitization and the lumbar spine (L5/6) was harvested. Then the lumbar spine block specimens were stained with Villaneuva bone stain and sectioned in the midsagittal plane...
March 2018: Yonago Acta Medica
Yuzuru Hosoda, Norihiko Hino, Toru Motokura
Background: Several prognostic indices for diffuse large B-cell lymphoma (DLBCL) have been developed. Which index is appropriate for Japanese patients with DLBCL treated in real-world practice is unknown. Methods: The prognostic performances of the original international prognostic index (IPI), age-adjusted IPI, National Comprehensive Cancer Network-IPI, elderly IPI and revised IPI were compared using patients with DLBCL treated in a single institute in the Yonago area in Japan...
March 2018: Yonago Acta Medica
Takuya Horie, Naoto Burioka, Takashi Amisaki, Eiji Shimizu
Background: Atrial fibrillation (AF) is an arrhythmia commonly encountered in clinical practice. There is a high risk of thromboembolism in patients with AF. Nonlinear analyses such as electroencephalogram (EEG), electrocardiogram (ECG), and respiratory movement have been used to quantify biological signals, and sample entropy (SampEn) has been employed as a statistical measure to evaluate complex systems. In this study, we examined the values of SampEn in ECG signals for patients with and without AF to measure the regularity and complexity...
March 2018: Yonago Acta Medica
Hiromi Watanabe, Reiko Okuda, Hiroshi Hagino
Background: Strong feelings about and enthusiasm for nursing care are reflected in nurses' thoughts and behaviors in clinical practice and affect their profession. This study was conducted to identify the characteristics of core values in nursing care based on the experiences of nurses engaged in neonatal nursing through a process for recognizing the conceptualization of nursing. Methods: We conceptualized nursing care in 43 nurses who were involved in neonatal nursing using a reflection sheet...
March 2018: Yonago Acta Medica
Eiji Matsusue, Yoshio Fujihara, Eiken Matsuda, Yusuke Tokuyasu, Shu Nakamoto, Kazuhiko Nakamura, Toshihide Ogawa
Background: Of all parotid gland tumors, only oncocytoma has been reported to appear isointense to the parotid gland, namely vanishing, on fat-saturated T2 and T1 postcontrast gadolinium-enhanced magnetic resonance imaging (MRI). The purpose of this study was to evaluate vanishing of parotid tumors on conventional MRI with and/or without postcontrast gadolinium-enhancement and on diffusion weighted imaging (DWI). Methods: In 8 of 51 patients, ten parotid gland tumors had homogeneously enhanced lesions and were retrospectively analysed...
March 2018: Yonago Acta Medica
Taku Iwamoto, Kazuo Yashima, Keiko Morio, Naoki Ueda, Yuichiro Ikebuchi, Koichiro Kawaguchi, Kenichi Harada, Hajime Isomoto
Background: The human leukocyte antigen (HLA) region has been found to be involved in the pathogenesis of inflammatory bowel disease (IBD), which is classified into ulcerative colitis (UC) and Crohn's disease (CD), by genome-wide association studies. The aim of this study was to confirm whether HLA-alleles confer susceptibility to UC and to determine whether HLA-allel1es are associated with the clinical phenotypes in Japanese patients with UC. Methods: In this study, HLA typing was performed by PCR-sequence-specific oligonucleotides (PCR-SSO) to confirm the correlation between UC and HLA alleles (for HLA-A, B, DRB1) in 45 Japanese UC patients...
March 2018: Yonago Acta Medica
Yuko Nishina, Shin-Ichi Yoshioka
Background: Comprehensive care is necessary for people with epilepsy (PWE) to lead a fulfilling life at home and in the community. The purpose of this study was to determine the epilepsy-related knowledge, attitudes and practices of home healthcare nurses (HHNs) in the San-in region of Japan. Methods: A questionnaire survey was conducted by mail of 546 HHNs working in Tottori and Shimane Prefectures. The questionnaire assessed the epilepsy-related knowledge, attitudes and practices of HHNs...
March 2018: Yonago Acta Medica
Yoshihiro Funaki, Yasuyuki Hasegawa, Ryota Okazaki, Akira Yamasaki, Yuriko Sueda, Akihiro Yamamoto, Masaaki Yanai, Takehito Fukushima, Tomoya Harada, Haruhiko Makino, Eiji Shimizu
Background: Resolvin E1 (RvE1) derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid is known to be a potent pro-resolving lipid mediator that prevents chronic inflammation and osteoclastogenesis. We investigated the inhibitory effects of RvE1 on osteoclastogenesis and bone resorption to clarify its therapeutic potential for rheumatoid arthritis (RA). Methods: Receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation was assessed with tartrate-resistant acid phosphatase staining...
March 2018: Yonago Acta Medica
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