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Yonago Acta Medica

Noriya Yamaguchi, Tetsuya Yumioka, Hideto Iwamoto, Toshihiko Masago, Shuichi Morizane, Masashi Honda, Takehiro Sejima, Atsushi Takenaka
BACKGROUND: High-risk prostate cancer treatment has been controversial. Some high-risk prostate cancer patients fail to respond to radical prostatectomy only. Thus, we aimed to investigate the predictive factors for biochemical recurrence (BCR) and identify patients who could achieve sufficient therapeutic effect by radical prostatectomy only. METHODS: Of 264 medical records reviewed, 141 low-intermediate-risk and 100 high-risk prostate cancer patients, excluding those who had received neoadjuvant hormone therapy, were analyzed...
December 2016: Yonago Acta Medica
Ayako Yamashita, Shin-Ichi Yoshioka
BACKGROUND: The aim of this study was to clarify the self-disclosure and risks of relapse associated with promoting resilience of patients with alcohol use disorders (AUD) and participating in self-help groups. METHODS: An anonymous, self-administered questionnaire survey was administered to 48 patients with AUD and participating in self-help groups; this questionnaire consisted of basic attributes, a bidimensional resilience scale to assess both innate and acquired resilience factors, a scale to assess depth of self-disclosure, and a scale assessing relapse risks...
December 2016: Yonago Acta Medica
Yuki Hashimoto, Yuki Hatayama, Nao Kojima, Shota Morishita, Satoko Matsumoto, Yuzuru Hosoda, Ayako Hara, Toru Motokura
BACKGROUND: Acute promyelocytic leukemia (APL) is a disease characterized by expression of Promyelocytic Leukemia-Retinoic Acid Receptor α (PML-RARα) chimeric mRNA. Although APL is curable, early death due to hemorrhage is a major problem. Here, we report the development of a simple and rapid diagnostic method for APL based on reverse transcription loop-mediated isothermal amplification (RT-LAMP). METHODS: An RT-LAMP primer set was designed to detect three types of PML-RARα mRNA in a single reaction...
December 2016: Yonago Acta Medica
Naoyuki Ueda, Haruki Nagira, Naoko Sannomiya, Saeko Ikunishi, Yuiko Hattori, Akira Kamida, Yuki Koyanagi, Kenta Shimabayashi, Kengo Sato, Hiroaki Saito, Yasuaki Hirooka
BACKGROUND: The therapeutic effect of chemotherapy for liver metastases is currently determined by changes in tumor diameter depicted on computed tomography (CT) and magnetic resonance imaging, but it cannot accurately determine if there is central necrosis. Furthermore, due to the risk of radiation exposure and high cost, frequent examination using these methods places a heavy burden on patients. Meanwhile, real-time observation of blood flow and vessel morphology within tumors has become possible by contrast-enhanced ultrasonography (CEUS)...
December 2016: Yonago Acta Medica
Kazuki Fukuma, Hisanori Kowa, Hiroyuki Nakayasu, Kenji Nakashima
We presented a 38-year-old woman suffering from acute cerebral infarction due to arteritis limited to bilateral internal carotid arteries without a condition of giant cell arteritis or granulomatosis with polyangitis. Our case is unprecedented and characterized by a young woman with wall enhancement in the internal carotid arteries on contrast-enhanced magnetic resonance imaging (MRI), therapeutic effects of steroids, and positive status for human leucocyte antigen-B39, -B51 and -DR4. These disease characteristics were not in accordance with existing diagnostic criteria of vasculitis, such as Takayasu's arteritis, giant cell arteritis, granulomatosis with polyangiitis, and Behcet's disease...
September 2016: Yonago Acta Medica
Hideyuki Kataoka, Shiro Arii, Takahiro Fukuhara, Kazunori Fujiwara, Yasuomi Kunimoto, Kensaku Hasegawa, Hiromi Takeuchi
It is difficult to directly observe glottal airflow velocity just above the glottis due to sensor size requirements and limited accessibility. We developed a miniature hot-wire probe and flexible fiberscopic high-speed imaging system for human examinations. Simultaneous direct measurement of glottal airflow velocity, subglottal pressure, and vocal fold vibration was achieved in a patient who was treated with a T-tube for tracheal stenosis. Airflow velocity changes at the anterior midline of the vocal folds were synchronized with subglottal pressure changes during each phonation cycle...
September 2016: Yonago Acta Medica
Takayoshi Kimura, Satoru Murata, Shiro Onozawa, Takahiko Mine, Tatsuo Ueda, Fumie Sugihara, Daisuke Yasui, Izumi Miki, Shinichiro Kumita, Toshihide Ogawa
We report the case of a man in his 70s who suffered from intestinal infarction caused by acute portal vein and mesenteric vein thrombosis (PVMVT). Combination therapy with percutaneous transcatheter thrombectomy and surgical bowel resection was successfully performed, and a satisfactory outcome was achieved. Intestinal infarction caused by PVMVT can be fatal and has a high mortality rate even if surgical resection is performed. The combination therapy of interventional radiology and surgery might be a safe and effective method for patients with this life-threatening condition...
September 2016: Yonago Acta Medica
Tomoyuki Matsunaga, Hiroaki Saito, Yuki Murakami, Hirohiko Kuroda, Yoji Fukumoto, Tomohiro Osaki
BACKGROUND: Supra-pancreatic lymph node dissection is important in patients undergoing laparoscopic gastrectomy (LG) for gastric cancer. A clear view of the supra-pancreatic area is necessary for precise dissection of supra-pancreatic lymph nodes without injury to the pancreas. This retrospective study assessed the efficacy of T-shaped gauze (TSG) in retracting the pancreas during supra-pancreatic lymph node dissection. METHODS: The study cohort consisted of 80 patients who underwent LG for gastric cancer...
September 2016: Yonago Acta Medica
Masato Nakasone, Kazuhiro Nakaso, Yosuke Horikoshi, Takehiko Hanaki, Yoshinori Kitagawa, Toru Takahashi, Yoshimi Inagaki, Tatsuya Matsura
BACKGROUND: Sepsis is a syndrome triggered by endotoxin lipopolysaccharide (LPS) during bacterial infection. Sepsis sometimes recurs, with the second sepsis giving rise to a different phenotype because of disease modification by the preceding sepsis. Such a protective modification is called a preconditioning (PC) effect. PC is an endogenous protective mechanism by which sublethal damage confers tolerance to a subsequent lethal load. Oxidative stress is one of the important pathogenetic mechanisms that occur in sepsis...
September 2016: Yonago Acta Medica
Yuki Hatayama, Yuki Hashimoto, Ayako Hara, Toru Motokura
BACKGROUND: For patients with reactivation of human cytomegalovirus (CMV), a highly sensitive and accurate CMV quantification system is essential to monitor viral load. METHODS: We constructed a real-time detection PCR (RTD-PCR) system for CMV DNA and evaluated its linearity, lower detection limit, dynamic range and accuracy using two CMV standards. We used 219 clinical samples derived from 101 patients to compare the system with the pp65 antigen test. RESULTS: The 95% detection limit was determined to be 556 IU/mL (95% CI, 440-797 IU/mL), and the quantification range was between 10(2) and 10(6) copies or IU/mL (r = 0...
September 2016: Yonago Acta Medica
Kader A T M Abdul, Yuki Murakami, Miwa Yoshimoto, Kazunari Onishi, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Shuichi Takano, Naruo Tokuyasu, Tomohiro Osaki, Hiroaki Saito, Masahide Ikeguchi
BACKGROUND: Postoperative complications have been shown to worsen prognoses of various cancer types. METHODS: We retrospectively analyzed 265 patients with stage II-III gastric cancer who underwent curative gastrectomies between 1991 and 2010 at Tottori University Hospital to determine the effect of postoperative intra-abdominal complication (IAC) on prognosis. RESULTS: Of the 265 patients, 38 (14.3%) developed postoperative IACs of grade ≥ 2, of whom significantly more patients were male...
September 2016: Yonago Acta Medica
Yuki Shinohara, Ayumi Kato, Eijiro Yamashita, Toshihide Ogawa
BACKGROUND: To evaluate the detectability of arterial acute thrombus on R2* map by iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) IQ compared with T2*-weighted imaging (T2*WI). METHODS: Twenty-six patients with acute cerebral infarction who underwent R2* map and T2*WI were reviewed. We performed visual assessment of each sequence regarding the visibility of susceptibility effect reflecting acute thrombus and quantitative evaluation of the thrombus on R2* map...
September 2016: Yonago Acta Medica
Ikuko Nishio, Masami Chujo
BACKGROUND: Resilience strategies are what we use to avoid and recover from error. In this study, we used the grounded theory approach to evaluate the resilience of Japanese patients with Type 1 diabetes. METHODS: Semi-structured interviews were conducted with 15 adults with Type 1 diabetes. Then, using grounded theory, we created a new model of resilience in this population. RESULTS: The results suggested a core category, "to make progress along the resilience path," comprising seven concepts classified into three stages...
September 2016: Yonago Acta Medica
Toru Takahashi, Kazuhiro Nakaso, Yosuke Horikoshi, Takehiko Hanaki, Miho Yamakawa, Masato Nakasone, Yoshinori Kitagawa, Taisuke Koike, Tatsuya Matsura
BACKGROUND: Vitamin E (VE, α-tocopherol) is a fat-soluble vitamin and is well known as an antioxidant. A deficiency in VE induces oxidative stress in the brain and causes motor and memory dysfunction. The consumption of a VE-rich diet has been given much attention in recent years, in regards to anti-aging and the prevention of age-related neuronal disorders. METHODS: A VE-deficient mouse model was prepared by feeding the animals a diet lacking VE. In addition, to evaluate the effect of VE-containing rice bran (RB) on VE deficiency, a diet including RB was also provided...
September 2016: Yonago Acta Medica
Shuji Suzuki, Yuichi Yoshida, Tatsushi Shiomi, Shigeto Yanagihara, Ryoko Kimura, Osamu Yamamoto
Umbilical melanoma is extremely rare. Among the past English reports on umbilical melanoma, there are only 8 reports in which histopathology was described in detail, and there has been no report with a review of the histopathology of previously reported cases. We experienced a case of umbilical melanoma and reviewed previously reported cases including our case. Because of the anatomical location, it is difficult to become aware of the umbilical melanoma unless there are some concomitant symptoms such as discharge or swelling...
June 2016: Yonago Acta Medica
Takeshi Endo, Natsumi Noda, Yasushi Kuromi, Kenji Kokura, Yasuhiro Kazuki, Mitsuo Oshimura, Tetsuya Ohbayashi
BACKGROUND: Hypoxanthine guanine phosphoribosyltransferase (Hprt) is known as a house-keeping gene, and has been used as an internal control for real-time quantitative RT-PCR and various other methods of gene expression analysis. To evaluate the Hprt mRNA levels as a reference standard, we engineered a luciferase reporter driven by a long Hprt promoter and measured its response to cytotoxicity. METHODS: We constructed a reporter vector that harbored a phiC31 integrase recognition site and a mouse Hprt promoter fused with green-emitting luciferase (SLG) coding sequence...
June 2016: Yonago Acta Medica
Akira Kamida, Kenta Shimabayashi, Masayoshi Oguri, Toshihiro Takamori, Naoyuki Ueda, Yuki Koyanagi, Naoko Sannomiya, Haruki Nagira, Saeko Ikunishi, Yuiko Hattori, Kengo Sato, Chisako Fukuda, Yasuaki Hirooka, Yoshihiro Maegaki
BACKGROUND: Attention deficit disorder/hyperactivity disorder (ADHD) is a pathological condition that is not fully understood. In this study, we investigated electroencephalographic (EEG) power differences between children with ADHD and healthy control children. METHODS: EEGs were recorded as part of routine medical care received by 80 children with ADHD aged 4-15 years at the Department of Pediatric Neurology in Tottori University Hospital. Additionally, we recorded in 59 control children aged 4-15 years after obtaining informed consent...
June 2016: Yonago Acta Medica
Naoko Sannomiya, Yuiko Hattori, Naoyuki Ueda, Akira Kamida, Yuki Koyanagi, Haruki Nagira, Saeko Ikunishi, Kenta Shimabayashi, Yuki Hashimoto, Aya Murata, Kengo Sato, Yumi Hirooka, Keiko Hosoya, Kiyosuke Ishiguro, Yoko Murata, Yasuaki Hirooka
BACKGROUND: Breast ultrasound findings regarding tumor margins are crucial in judging whether a tumor is malignant or benign. However, the relationships between the margins and clinicopathological characteristics remain largely unknown. In this study, we examined the clinicopathological characteristics of patients with invasive ductal carcinoma whose ultrasound images showed either well-defined and rough or indistinct margins. METHODS: Of all consecutive patients diagnosed with invasive ductal carcinoma at the Division of Breast and Endocrine Surgery of Tottori University Hospital from January 2012 to December 2014, 122 patients whose ultrasound images showed either "well-defined and rough" or "indistinct" tumor margins were included in this study...
June 2016: Yonago Acta Medica
Shunjiro Yagi, Yoshiko Suyama, Kohei Fukuoka, Hiromi Takeuchi, Hiroya Kitano
BACKGROUND: Recipient vessel selection in head and neck reconstruction using free flap transfers has to be standardized. However, the recipient vessel selection based on the type of neck dissection has yet to be investigated. We describe the relationship between the type of neck dissection and recipient vessel. METHODS: Records of 107 consecutive patients who had undergone head and neck reconstruction using free flap transfers from 2011 to 2015 were reviewed retrospectively...
June 2016: Yonago Acta Medica
Weibin Qian, Xinrui Cai, Xinying Zhang, Yingying Wang, Qiuhai Qian, Junichi Hasegawa
BACKGROUND: Daisaikoto (DSKT), a classical traditional Chinese herbal formula, has been used for treating digestive diseases for 1800 years in China. Therefore, in this study, we are going to investigate the effect of DSKT on diabetic fatty liver rats induced by a high-fat diet and streptozotocin (STZ), and the effects of DSKT on silent mating type information regulation 2 homolog 1 (SIRT1) and nuclear factor kappa B (NF-kappaB). METHODS: Diabetic fatty liver rat model was selected to establish a high-fat diet and STZ...
June 2016: Yonago Acta Medica
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