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Vox Sanguinis

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https://www.readbyqxmd.com/read/28809049/evolution-of-mnc-and-lymphocyte-collection-settings-employing-different-spectra-optia-%C3%A2-leukapheresis-systems
#1
M Punzel, A Kozlova, A Quade, A H Schmidt, R Smith
BACKGROUND AND OBJECTIVES: The Spectra Optia(®) continuous mononuclear cell (CMNC apheresis) system has emerged as the preferred device in peripheral blood stem cell collections over the original two-step Spectra Optia(®) mononuclear cell (MNC apheresis) system. Until now, no comparative data were available for non-stimulated MNC collections that are required for immunotherapy. MATERIALS AND METHODS: We compared collection parameters and product composition for Spectra Optia MNC- as well as CMNC-apheresis systems in non-stimulated MNC collections from 35 registry donors intended for donor lymphocyte infusions...
August 14, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28809046/platelet-transfusion-to-reverse-antiplatelet-therapy-before-decompressive-surgery-in-patients-with-intracranial-haemorrhage
#2
M Baschin, S Selleng, J-P Zeden, A Westphal, T Kohlmann, H W Schroeder, A Greinacher, T Thiele
BACKGROUND: Platelet concentrates (PC) are transfused to improve primary haemostasis before urgent neurosurgery in patients with intracranial haemorrhage (ICH) receiving antiplatelet therapy (APT). It is unresolved, whether PCs increase the risk for major cardio- and cerebrovascular adverse events. We evaluated a standardized transfusion regimen to reverse APT in patients with ICH who required decompressive neurosurgery. METHODS: Analysed were consecutive patients between 2012 and 2014...
August 14, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28639703/an-assessment-of-differences-in-costs-and-health-benefits-of-serology-and-nat-screening-of-donations-for-blood-transfusion-in-different-western-countries
#3
M P Janssen, M van Hulst, B Custer
BACKGROUND AND OBJECTIVES: The cost-utility of safety interventions is becoming increasingly important as a driver of implementation decisions. The aim of this study was to compare the cost-utility of different blood screening strategies in various settings, and to analyse the extent and cause of differences in health economic results. MATERIALS AND METHODS: For eight Western countries (Australia, Canada, Denmark, Finland, France, The Netherlands, UK and the United States of America), data were collected on donor and recipient populations, blood products, screening tests, and on patient treatment practices and costs...
June 22, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28639693/thromboelastography-may-predict-risk-of-grade-2-bleeding-in-thrombocytopenic-patients
#4
E N Opheim, T O Apelseth, S J Stanworth, G E Eide, T Hervig
BACKGROUND AND OBJECTIVES: Platelet count is used as a prophylactic platelet transfusion trigger, although evidence suggests that it is a poor predictor of bleeding. Thus, alternative tests are required. The primary objective of this study was to compare thromboelastography (TEG) parameters on days with and without bleeding symptoms. The secondary objectives were to investigate the relationship between TEG parameters and haematological variables, fever, C-reactive protein (CRP) and platelet transfusion...
June 22, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28635130/prothrombin-complex-concentrate-for-emergent-reversal-of-warfarin-an-international-survey-of-hospital-protocols
#5
J Gorlin, S Kinney, M K Fung, A Tinmouth
For emergent warfarin reversal, four-factor prothrombin complex concentrates (4FPCCs) are recommended by many international guidelines. We surveyed international clinical sites including members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Most sites have emergent warfarin reversal protocols (53% use PCC, 25% use PCC+ plasma and 2% use plasma alone); however, variation between adjusted dosing and fixed dosing was observed.
June 21, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28612932/prehospital-parameters-can-help-to-predict-coagulopathy-and-massive-transfusion-in-trauma-patients
#6
J-S David, E-J Voiglio, E Cesareo, O Vassal, E Decullier, P-Y Gueugniaud, S Peyrefitte, K Tazarourte
BACKGROUND: This study aimed to evaluate the accuracy of prehospital parameters, including vital signs and resuscitation (fluids, vasopressor), to predict trauma-induced coagulopathy (TIC, fibrinogen <1·5 g/l or PTratio > 1·5 or platelet count <100 × 10(9) /l), and a massive transfusion (MT, ≥10 RBC units within the first 24 h). METHODS: From a trauma registry (2011-2015), in which patients are prospectively included, we retrospectively retrieved the heart rate (HR), systolic blood pressure (SBP), volume of prehospital fluids and administration of noradrenaline...
June 14, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28597485/comparison-of-haemostatic-function-of-pas-c-platelets-vs-plasma-platelets-in-reconstituted-whole-blood-using-impedance-aggregometry-and-thromboelastography
#7
F M A van Hout, I J Bontekoe, L A E de Laleijne, J-L Kerkhoffs, D de Korte, J Eikenboom, J G van der Bom, P F van der Meer
BACKGROUND AND OBJECTIVES: There are concerns about the haemostatic function of platelets stored in platelet additive solution (PAS). Aim of this study was to compare the haemostatic function of PAS-C-platelets to plasma-platelets in reconstituted whole blood. MATERIALS AND METHODS: In our experiment, whole blood was reconstituted with red blood cells, solvent-detergent (SD) plasma and either PAS-C-platelets or plasma-platelets (n = 7) in a physiological ratio. On storage days 2, 5, 8 and 13, the agonist-induced aggregation (multiple electrode aggregometry), clot formation (thromboelastography) and agonist-induced CD62P responsiveness (flow cytometry) were measured...
June 9, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28597520/the-impact-of-vaccination-on-rbc-alloimmunization-in-a-murine-model
#8
P Natarajan, M Santhanakrishnan, C A Tormey, J E Hendrickson
Emerging data in animal models and humans suggest that pathogen-associated and damage-associated molecular patterns variably impact RBC alloantibody formation. In this study, we tested the hypothesis that vaccinations may enhance immune responses to transfused RBCs. The Pneumovax23 vaccine decreased the magnitude of anti-KEL alloimmunization in a murine model, whereas the hepB vaccine did not impact the response; RBC transfusion did not alter immune responses to either vaccine. These data highlight the complexities of the intersection of innate and adaptive immunity and suggest that future studies investigating the pathways through which inflammation impacts alloimmunization are warranted...
June 8, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28597489/development-of-a-web-based-application-and-multicountry-analysis-framework-for-assessing-interdicted-infections-and-cost-utility-of-screening-donated-blood-for-hiv-hcv-and-hbv
#9
B Custer, M P Janssen, G Hubben, M Vermeulen, M van Hulst
BACKGROUND AND OBJECTIVES: Most countries test donations for HIV, HCV and HBV using serology with or without nucleic acid testing (NAT). Cost-utility analyses provide information on the relative value of different screening options. The aim of this project was to develop an open access risk assessment and cost-utility analysis web-tool for assessing HIV, HCV and HBV screening options (http://www.isbtweb.org/working-parties/transfusion-transmitted-infectious-diseases/). An analysis for six countries (Brazil, Ghana, the Netherlands, South Africa, Thailand and USA) was conducted...
June 8, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28580663/autologous-blood-salvage-in-the-era-of-patient-blood-management
#10
REVIEW
R A Sikorski, N A Rizkalla, W W Yang, S M Frank
Almost 150 years after the first autologous blood transfusion was reported, intraoperative blood salvage has become an important method of blood conservation. The primary goal of autologous transfusion is to reduce or avoid allogeneic red blood cell transfusion and the associated risks and costs. Autologous salvaged blood does not result in immunological challenge and its consequences, provides a higher quality red blood cell that has not been subjected to the adverse effects of blood storage, and can be more cost-effective than allogeneic blood when used for carefully selected surgical patients...
June 5, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28560760/oral-antiplatelet-therapy-impact-for-transfusion-medicine
#11
REVIEW
T Gremmel, S Panzer
Patients on antiplatelet therapy, be it aspirin only, or aspirin in combination with oral adenosine diphosphate (ADP) receptor inhibitors like clopidogrel, prasugrel and ticagrelor, or the protease-activated receptor-1 inhibitor vorapaxar, may develop bleeding or need transient reversal of platelet blockade for acute interventions. In this review, we summarize reports on patients with antiplatelet therapy receiving platelet concentrates due to bleeding, and in vitro experiments estimating the feasibility to restore platelet function by spiking blood from healthy individuals or patients on antiplatelet treatment with noninhibited platelets...
May 30, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28727152/diary-of-events
#12
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28727151/erratum
#13
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28369949/evaluating-the-impact-of-the-abo-blood-group-on-the-clinical-outcome-of-thrombotic-thrombocytopenic-purpura-associated-with-severe-adamts13-deficiency
#14
E Hussein, J Teruya
BACKGROUND AND OBJECTIVES: Thrombotic thrombocytopenic purpura (TTP) is caused by the decrease of ADAMTS13, leading to the accumulation of ultra large von Willebrand factor (ULVWF). It was proposed that the distribution of blood group O among TTP patients may be potentially lower than expected because of the lower levels of VWF. The aim of this study was to explore the relationship between various blood groups and the clinical outcome in TTP. MATERIALS AND METHODS: Thirty-three patients with TTP with severe ADAMTS13 deficiency were studied...
July 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28608429/27th-regional-congress-of-the-isbt-copenhagen-denmark-june-17-21-2017
#15
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28524359/development-of-rbc-transfusion-indications-and-the-collection-of-patient-specific-pre-transfusion-information
#16
LETTER
M H Yazer, L van de Watering, M Lozano, S Sirdesai, K Rushford, E M Wood, A P Yokoyama, J M Kutner, Y Lin, J Callum, C Cserti-Gazdewich, L Lieberman, J Pendergrast, K Pendry, M F Murphy, K Selleng, A Greinacher, N Marwaha, R Sharma, A Jain, Y Orlin, V Yahalom, P Perseghin, A Incontri, N Masera, H Okazaki, T Ikeda, Y Nagura, J J Zwaginga, R Pogłod, A Rosiek, M Letowska, J Yuen, J Cid, S K Harm, P Adhikari
No abstract text is available yet for this article.
May 19, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28524235/development-of-rbc-transfusion-indications-and-the-collection-of-patient-specific-pre-transfusion-information-summary
#17
LETTER
M H Yazer, L van de Watering, M Lozano, S Sirdesai, K Rushford, E M Wood, A P Yokoyama, J M Kutner, Y Lin, J Callum, C Cserti-Gazdewich, L Lieberman, J Pendergrast, K Pendry, M F Murphy, K Selleng, A Greinacher, N Marwaha, R Sharma, A Jain, Y Orlin, V Yahalom, P Perseghin, A Incontri, N Masera, H Okazaki, T Ikeda, Y Nagura, J J Zwaginga, R Pogłod, A Rosiek, M Letowska, J Yuen, J Cid, S K Harm, P Adhikari
No abstract text is available yet for this article.
May 19, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28516477/a-prospective-observational-study-on-effects-of-fever-on-red-cell-transfusion-outcome
#18
Ø Wendelbo, E Netland Opheim, T H Felli Lunde, Ø Bruserud, T Hervig, H Reikvam
The effects of fever on red cell transfusions are not well documented. In this pilot study, we have compared the outcome of red-blood-cell transfusions in haematologic patients with and without fever. The results indicate that haemoglobin increment per unit is significantly lower in febrile patients receiving red cell transfusions than in patients without fever. These findings are in line with earlier findings in preclinical studies. Larger studies are necessary to confirm our results, and laboratory studies should be conducted to investigate the underlying mechanisms...
May 18, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28516443/multiple-red-blood-cell-transfusions-and-iron-overload-in-very-low-birthweight-infants
#19
J D Treviño-Báez, E Briones-Lara, J Alamillo-Velázquez, M I Martínez-Moreno
BACKGROUND AND OBJECTIVES: To estimate the risk of iron overload in very low birthweight (VLBW) infants who receive more than two red blood cell (RBC) transfusions, in comparison with those who receive two or less during their hospital stay. MATERIALS AND METHODS: Prospective open cohort study in VLBW infants with >2 (exposed) and ≤2 (non-exposed) RBC transfusions. Ferritin, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured at birth and after each RBC transfusion...
May 18, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28466601/adult-extracorporeal-membrane-oxygenation-an-international-survey-of-transfusion-and-anticoagulation-techniques
#20
S A Esper, I J Welsby, K Subramaniam, W John Wallisch, J H Levy, J H Waters, D J Triulzi, J W A Hayanga, G J Schears
BACKGROUND AND OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) is a method of life support for either isolated cardiac failure or respiratory failure, with or without cardiac failure. When used for hemodynamic support, the ECMO circuit presents a non-endothelialized, artificial surface to blood inciting an inflammatory response which activates haemostatic pathways. Anticoagulation may complicate a pre-existing coagulopathy and/or inadequate surgical hemostasis of varying severity...
May 3, 2017: Vox Sanguinis
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