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Vox Sanguinis

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https://www.readbyqxmd.com/read/30003551/identification-of-transfusion-transmitted-hepatitis-a-through-postdonation-information-in-korea-results-of-an-hav-lookback-2007-2012
#1
M J Kim, J Y Shin, J A Oh, K E Jeong, Y S Choi, Q Park, M S Song, D H Lee
BACKGROUND AND OBJECTIVES: Despite safety measures to minimize the risk of transfusion-transmitted infections, a residual risk remains. To trace and review some such cases, we ask donors to notify the blood centre if they are diagnosed with an infection after they donate blood. MATERIALS AND METHODS: We analysed all data on postdonation cases of hepatitis A reported between 2007 and 2012. Archived specimens from these donors were tested for hepatitis A virus (HAV) using anti-HAV IgM/IgG and HAV-PCR as markers...
July 13, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29978484/a-novel-mutation-5904-c-t-of-runx1-site-in-the-erythroid-cell-specific-regulatory-element-decreases-the-abo-antigen-expression-in-chinese-population
#2
Y Ying, X Hong, X Xu, K Ma, J He, F Zhu
BACKGROUND: An erythroid cell-specific regulatory element (+5·8-kb) in the first intron of ABO is responsible for the antigen differential expression and the regulatory activity of the element was affected by the nucleotide mutation in the +5·8-kb region. Currently, many individuals with ABO subgroups were found in the Chinese population, but there was little information about the function of +5·8-kb region in these individuals. Here, we studied the mechanism of the mutation in the +5·8-kb region responsible for reducing of antigen expression in 30 ABO subtype Chinese individuals without mutation in the coding region or splicing site...
July 5, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29974475/false-positive-viral-marker-results-in-blood-donors-and-their-unintended-consequences
#3
REVIEW
Philip Kiely, Veronica C Hoad, Erica M Wood
False positive (FP) viral marker results in blood donors continue to pose many challenges. Informing donors of FP results and subsequent deferral can result in stress and anxiety for donors and additional complexity and workload for blood services. Donor management strategies need to balance the requirement to minimise donor anxiety and inconvenience while maintaining sufficiency of supply. Decisions about how and when to inform donors of FP results and determine deferral periods can be difficult as FP results, while often transitory, can take up to several years to resolve...
July 4, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29971786/rapid-bedside-rejuvenation-of-red-blood-cell-with-an-autologous-cell-salvage-device
#4
G Enten, P Dalvi, N Martini, K Kausch, A Gray, M Landrigan, D Mangar, E Camporesi
BACKGROUND AND OBJECTIVES: During storage, red blood cells (RBCs) undergo physicochemical changes which affect the quality, function, and in vivo survival of transfused packed RBCs (pRBC). Changes include decreased 2,3-diphosphoglycerate (2,3-DPG) levels, decreased ATP, changes in mechanical properties and oxidative injury. RBC rejuvenation is a method used to increase levels of 2,3-DPG and ATP in pRBCs. This process requires incubating the pRBCs with a rejuvenation solution and subsequent washing...
July 3, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29947125/international-forum-on-typing-and-matching-strategies-in-patients-on-anti-cd38-monoclonal-therapy
#5
K M K De Vooght, M Lozano, J-L Bueno, A Alarcón, I Romera, K Suzuki, E Zhiburt, A Holbro, L Infanti, A Buser, H Hustinx, V Deneys, A Frélik, C Thiry, M Murphy, J Staves, K Selleng, A Greinacher, J M Kutner, C Bonet Bub, L Castilho, R M Kaufman, M E Colling, P Perseghin, A Incontri, M Dassi, D Brilhante, A Macédo, C Cserti-Gazdewich, J M Pendergrast, J Hawes, M N Lundgren, J R Storry, A Jain, N Marwaha, R R Sharma
No abstract text is available yet for this article.
June 26, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29923207/impact-of-prestorage-leucoreduction-of-autologous-whole-blood-on-length-of-hospital-stay-with-a-subgroup-analysis-in-bilateral-hip-arthroplasty
#6
Y Sawamura, H Ohto, K Ikeda, T Kanno, Y Suzuki, K Gonda, T Tasaki, K E Nollet, H Takahashi, S Aota
BACKGROUND: Although prestorage leucoreduction (LR) of blood components for transfusion has gained favour around the world, evidence of its beneficial clinical effects is ambiguous. STUDY DESIGN AND METHODS: To reveal whether leucocytes and/or platelets in transfused blood are related to transfusion-related adverse effects, a prospective randomized crossover study was performed on patients who donated autologous blood prior to elective surgery. Among 1487 primary enrolees, a total of 192 patients undergoing two-stage, bilateral total hip arthroplasty were randomized to receive autologous blood that was either prestorage leucoreduced, or not, for the first procedure...
June 20, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29882331/blood-donors-with-epilepsy-continue-to-face-unjustified-discriminatory-practices
#7
LETTER
A Krumholz, P M Ness
No abstract text is available yet for this article.
June 7, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29864792/rejuvenation-of-allogenic-red-cells-benefits-and-risks
#8
REVIEW
H Aujla, M Woźniak, T Kumar, G J Murphy
BACKGROUND AND OBJECTIVES: To review preclinical and clinical studies that have evaluated the effects of red cell rejuvenation in vivo and in vitro and to assess the potential risks and benefits from their clinical use. MATERIALS AND METHODS: A systematic review and narrative synthesis of the intervention of red cell rejuvenation using a red cell processing solution containing inosine, pyruvate, phosphate and adenine. Outcomes of interest in vitro were changes in red cell characteristics including adenosine triphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG), deformability and the accumulation of oxidized lipids and other reactive species in the red cell supernatant...
June 4, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29799121/failure-of-bacterial-screening-to-detect-staphylococcus-aureus-the-english-experience-of-donor-follow-up
#9
S R Brailsford, J Tossell, R Morrison, C P McDonald, T L Pitt
BACKGROUND AND OBJECTIVES: Between February 2011 and December 2016, over 1·6 million platelet units, 36% pooled platelets, underwent bacterial screening prior to issue. Contamination rates for apheresis and pooled platelets were 0·02% and 0·07%, respectively. Staphylococcus aureus accounted for 21 contaminations, including four pooled platelets, one confirmed transfusion-transmitted infection (TTI) and three 'near-miss' incidents detected on visual inspection which were negative on screening...
May 24, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29797724/the-behaviour-and-perception-of-illness-modulating-variables-of-adherence-in-patients-with-haemophilia
#10
A Torres-Ortuño, R Cuesta-Barriuso, J Nieto-Munuera, P Galindo-Piñana, J-A López-Pina
BACKGROUND: The recommended treatment in patients with severe haemophilia is prophylaxis. This prevents bleedings and reduces or delays the haemophilic arthropathy. Adherence defined as the follow-up of the patient to the prescriptions of the health professional to his treatment, both pharmacological and modifications in habits or stylelifes. Adherence rates in haemophilia are better than in other chronic diseases, but there remain reasons for nonadherence. The aim was to see if disease behaviour and disease perception together with coping strategies modulate adherence to treatment...
May 24, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29797720/comparison-of-three-commercially-available-buffy-coat-pooling-sets-for-the-preparation-of-platelet-concentrates
#11
H B Feys, R Devloo, B Sabot, J Coene, V Compernolle
BACKGROUND: A disposable set for platelet concentrate (PC) preparation by the buffy coat method allows pooling of buffy coats, centrifugation and cell separation with in-line leucocyte filtration. This study compares three commercially available pooling sets in combination with INTERCEPT pathogen inactivation (PI). MATERIALS AND METHODS: Sets for pooling of buffy coats were from Fresenius Kabi (FRE), Macopharma (MAC) and Terumo BCT (TER). Platelet yield, recovery and concentration were compared before and after PI (n = 20)...
May 24, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29786866/characterization-of-efficacy-and-safety-of-pathogen-inactivated-and-quarantine-plasma-in-routine-use-for-treatment-of-acquired-immune-thrombotic-thrombocytopenic-purpura
#12
R Herbrecht, M Ojeda-Uribe, D Kientz, C Fohrer, A Bohbot, O Hinschberger, K-L Liu, E Remy, C Ernst, J-S Lin, L Corash, J P Cazenave
BACKGROUND: Auto-immune thrombotic thrombocytopenic purpura (TTP) is a morbid multi-organ disorder. Cardiac involvement not recognized in initial disease descriptions is a major cause of morbidity. Therapeutic plasma exchange (TPE) requires exposure to multiple plasma donors with risk of transfusion-transmitted infection (TTI). Pathogen inactivation (PI) with amotosalen-UVA, the INTERCEPT Blood System for Plasma (IBSP) is licensed to reduce TTI risk. METHODS: An open-label, retrospective study evaluated the efficacy of quarantine plasma (QP) and IBSP in TTP and defined treatment emergent cardiac abnormalities...
May 21, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29785800/organizational-models-for-health-actions-in-the-field-of-blood-and-blood-products-in-brazilian-and-spanish-regional-contexts
#13
M K B Souza
BACKGROUND AND OBJECTIVES: This article aims to characterize some elements that define the organizational models of healthcare actions in the field of blood and blood products. MATERIALS AND METHODS: This exploratory and qualitative study was carried out based on a documentary survey complemented by interviews with key informants of hemotherapy services from three regional territories in Spain and Brazil. RESULTS: It was evidenced demographic, territorial and organizational characteristics, as well as on instruments, resources and individuals involved in the planning, organization and implementation of services and actions in the area...
May 21, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29781081/vox-sanguinis-international-forum-on-typing-and-matching-strategies-in-patients-on-anti-cd38-monoclonal-therapy-summary
#14
K M K de Vooght, M Lozano, J-L Bueno, A Alarcón, I Romera, K Suzuki, E Zhiburt, A Holbro, L Infanti, A Buser, H Hustinx, V Deneys, A Frélik, C Thiry, M Murphy, J Staves, K Selleng, A Greinacher, J M Kutner, C Bonet Bub, L Castilho, R Kaufman, M E Colling, P Perseghin, A Incontri, M Dassi, D Brilhante, A Macêdo, C Cserti-Gazdewich, J M Pendergrast, J Hawes, M N Lundgren, J R Storry, A Jain, N Marwaha, R R Sharma
No abstract text is available yet for this article.
May 20, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29774554/laboratory-assessment-of-the-quality-of-adult-and-neonatal-red-cell-concentrates-manufactured-from-whole-blood-exchange-transfusion-or-intrauterine-transfusion-red-cell-units
#15
A Meli, H New, M McAndrew, M Wiltshire, R Cardigan
BACKGROUND: We evaluated the quality of red cell components in additive solution over 42 days of storage when re-manufactured from neonatal exchange transfusion (ExTx) or intrauterine transfusion (IUT) units on day 7 for issue to adults, neonates or infants. MATERIALS AND METHODS: Red cell concentrates (RCC) manufactured from WB were compared to RCC re-manufactured from ExTx or IUT on day 7, and red cell splits (RCS) manufactured from WB were compared to RCS re-manufactured from ExTx or IUT on day 7...
May 17, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29761923/accuracy-of-a-history-of-blood-donation-from-surrogate-witnesses-data-from-the-uk-tmer-study
#16
J M Mackenzie, M Turner, K Morris, S Field, A M Molesworth, S Pal, R G Will, C A Llewelyn, P E Hewitt
Look-back studies of blood transfusion in Creutzfeldt-Jakob disease commonly rely on reported history from surrogate witnesses. Data from the UK Transfusion Medicine Epidemiology Review have been analysed to determine the accuracy of the blood donation history provided by the relatives of cases. Our results show that only a small percentage of cases were found to be registered as donors on UK Blood Service (UKBS) databases when there was no family report of blood donation. In contrast, a history of reported donation was less accurate...
May 15, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29761839/effects-of-plasma-transfusions-on-antithrombin-levels-after-paediatric-liver-transplantation
#17
D Arni, B E Wildhaber, V McLin, P C Rimensberger, M Ansari, P Fontana, O Karam
BACKGROUND AND OBJECTIVES: Thrombotic complications affect 3-10% of patients after liver transplantation (LT), leading to potentially life-threatening complications. In the days following LT, antithrombin (AT) is decreased longer than pro-coagulant factors, thus favouring a pro-thrombotic profile. Plasma transfusions are given empirically in some centres to correct AT levels following LT. We assessed the effect of plasma transfusion on AT levels after paediatric LT. MATERIALS AND METHODS: Prospective single-centre observational study in 20 consecutive paediatric LT recipients over a 24-month period...
May 15, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29740847/junior-doctors-perspectives-on-transfusion-education-in-australia
#18
C J Flores, B Quested, T Spigiel, A Thomson, B Saxon
BACKGROUND: Early postgraduate training is a critical period to develop skills and to influence future clinical practice. Little is known about Australian junior doctors' existing transfusion knowledge and its application in patient care. This study explored their transfusion practice education preferences, developed tools to assist their practice and assessed the usefulness of these tools. METHODS: A design-based study was conducted in two phases from April 2016 to March 2017...
May 8, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29732562/irradiation-and-prolonged-storage-of-red-cells-are-associated-with-increased-adverse-events
#19
J Chen, E Biller, M Losos, J Li, D Hamad, L Blower, M Grevenow, J Oakley
BACKGROUND: Red blood cell (RBC) transfusion is associated with the most transfusion-related adverse events (AE). Recent clinical studies showed no significant difference in transfusion-associated mortality between fresh and older RBCs. However, the impact of storage duration as well as irradiation on nonfatal yet much more common complications has not been fully investigated. MATERIALS/METHODS: In this retrospective study of RBC transfusion-associated AEs, a total of 188,562 units of leucocyte-reduced RBCs were transfused in approximately 5·5 years...
May 6, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29726014/p-r180c-mutation-of-glycosyltransferase-b-leads-to-b-subgroup-an-in-vitro-and-in-silico-study
#20
X Cai, F Li, H Lei, S Qu, C Qian, D Xiang, D-Q Wei, W Wu, Q Xu, X Wang
BACKGROUND AND OBJECTIVES: Dysfunctional glycosyltransferase A or B may lead to incomplete glycosylation of H antigen and atypical ABO blood group with weak A or B phenotypes, posing challenges for blood typing for transfusion. MATERIALS AND METHODS: Serological studies and ABO gene analysis were performed. Flow cytometry was performed on HeLa cells transfected glycosyltransferase B expressing plasmids. Agglutination of transfected cells and total glycosyltransferase B transfer capacity were examined...
May 4, 2018: Vox Sanguinis
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