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Vox Sanguinis

Jill R Storry, Frederik Banch Clausen, Lilian Castilho, Qing Chen, Geoff Daniels, Greg Denomme, Willy A Flegel, Christoph Gassner, Masja de Haas, Catherine Hyland, Ji Yanli, Margaret Keller, Christine Lomas-Francis, Nuria Nogues, Martin L Olsson, Thierry Peyrard, Ellen van der Schoot, Yoshihiko Tani, Nicole Thornton, Franz Wagner, Christoph Weinstock, Silvano Wendel, Connie Westhoff, Vered Yahalom
BACKGROUND AND OBJECTIVES: The International Society of Blood Transfusion (ISBT) Working Party for Red Cell Immunogenetics and Blood Group Terminology meets in association with the ISBT congress and has met three times since the last report: at the international meetings held in Dubai, United Arab Emirates, September 2016 and Toronto, Canada, June 2018; and at a regional congress in Copenhagen, Denmark, June 2017 for an interim session. METHODS: As in previous meetings, matters pertaining to blood group antigen nomenclature and classification were discussed...
November 12, 2018: Vox Sanguinis
Susana Gómez-Ramírez, María Ángeles Maldonado-Ruiz, Arturo Campos-Garrigues, Antonio Herrera, Manuel Muñoz
In major orthopaedic surgery, it is recommended to detect and correct preoperative anaemia several weeks prior to surgery. However, in many cases, the procedure is urgent or the patient is evaluated shortly before the intervention. As iron deficiency is the leading cause of perioperative anaemia, an exhaustive review of the literature was performed to assess the efficacy and safety of short-term perioperative intravenous, with or without erythropoietin, or postoperative oral or intravenous supplementation in major orthopaedic surgery...
November 9, 2018: Vox Sanguinis
Lisanne E Heeger, Clare E Counsilman, Vincent Bekker, Klasien A Bergman, Jaap Jan Zwaginga, Arjan B Te Pas, Enrico Lopriore
OBJECTIVE: To evaluate red blood cell (RBC) transfusion practices in preterm neonates before and after protocol change. METHODS: All preterm neonates (<32 weeks of gestation) admitted between 2008 and 2017 at our neonatal intensive care unit were included in this retrospective study. Since 2014, a more restrictive transfusion guideline was implemented in our unit. We compared transfusion practices before and after this guideline change. Primary outcome was the number of transfusions per neonate and the percentage of neonates receiving a blood transfusion...
November 8, 2018: Vox Sanguinis
Sheila F O'Brien, Qi-Long Yi, Mindy Goldman, Yves Grégoire, Gilles Delage
BACKGROUND AND OBJECTIVES: In Canada, transfusion transmission risk of Human T-cell lymphotropic virus -I/II (HTLV) is addressed by universal leucoreduction and universal antibody testing. We aimed to estimate the risk with the current policy, if testing only first-time donors and if testing were stopped. MATERIALS AND METHODS: Monte Carlo simulation was employed to estimate the proportion of red cell concentrate, random donor platelet and apheresis platelet units that would be released into inventory in each scenario (10 billion donors each)...
November 4, 2018: Vox Sanguinis
Holger Budde, Susanne Papert, Holger M Reichardt, Hubertus Jarry, Joachim Riggert, Tobias J Legler
BACKGROUND AND OBJECTIVE: Extracorporeal photopheresis (ECP) is an important immune tolerance inducing therapy for graft-versus-host disease (GvHD). However, a sufficient number of ECP cycles cannot be performed in patients with severe GvHD and contraindications for apheresis. Allogeneic sources of leucocytes for use as ECP treatment would be of great benefit. Therefore, this study aimed to test the therapeutic potential of novel sources of leucocytes for ECP. MATERIALS AND METHODS: Graft-versus-host disease mice were treated with ECP using therapeutic cells from different allogeneic sources...
October 23, 2018: Vox Sanguinis
M H Yazer, P C Spinella, S Allard, D Roxby, C So-Osman, M Lozano, K Gunn, A W Shih, J Stensballe, P I Johansson, M Bagge Hansen, M Maegele, H Doughty, N Crombie, D H Jenkins, A C McGinity, R M Schaefer, C Martinaud, E Shinar, R Strugo, J Chen, H Russcher
No abstract text is available yet for this article.
October 21, 2018: Vox Sanguinis
Maria Bianchi, Patrizia Papacci, Caterina Giovanna Valentini, Ombretta Barbagallo, Giovanni Vento, Luciana Teofili
The prevention and treatment of anaemia in newborn patients made tremendous progress in the last decades. However, red-blood-cell (RBC) transfusions remain unavoidable in many neonates candidate to surgery and especially in preterm infants. In particular, anaemia occurring in neonates born at extremely low gestational age is actually severe and frequently requires transfusions. Several approaches have been explored to prevent or even to reduce the threshold and the frequency of RBC transfusions. Among these, umbilical cord blood (UCB) collection and processing to obtain RBC components for autologous or allogeneic transfusion have been extensively investigated...
October 16, 2018: Vox Sanguinis
Christel Kamp, Johannes Blümel, Sally A Baylis, Isabelle Bekeredjian-Ding, Michael Chudy, Margarethe Heiden, Olaf Henseler, Brigitte Keller-Stanislawski, Anneke S de Vos, Markus B Funk
Hepatitis E virus (HEV) infections may be acquired through transfusion of blood components. As transfusion-transmitted infections mostly affect vulnerable individuals, measures to ensure the supply of safe blood components are under discussion. On the basis of the epidemiological situation in Germany, different testing strategy scenarios were investigated through simulation studies. Testing for HEV RNA by nucleic acid amplification technique (NAT) assays with a pool size of 96, and a 95% LoD of 20 IU/ml will result in an 80% reduction in expected HEV transmissions as well as of consequent chronic infections with subsequent severe complications...
October 14, 2018: Vox Sanguinis
Claire E Styles, Veronica C Hoad, Clive R Seed
Repeat donors in Australia will shortly cease to be tested for human T-lymphotropic virus (HTLV), removing the ability to measure repeat donor incidence. A risk threshold for repeat donors was investigated based on previous modelling and a conservative ratio between prevalent and incident infections. It was estimated that 26 infections per 100 000 new-donor donations would be associated with an incidence in repeat donors approaching the tolerable risk threshold if sustained over several years. We propose to trigger formal risk assessment at this point, and believe this solution may be useful for other blood services that reduce their HTLV testing requirements...
October 14, 2018: Vox Sanguinis
Agneta Wikman, Elisabeth Jalkesten, Gunilla Ajne, Petter Höglund, Anette Mörtberg, Eleonor Tiblad
BACKGROUND: The optimal strategy to monitor RhD-immunized pregnancies is not evident. Whether a quantitative analysis of anti-D antibodies adds valuable information to anti-D titre is unclear. The aim of this study was to evaluate the relevance of anti-D quantification in routine monitoring of RhD-immunized pregnancies. MATERIALS AND METHODS: In a retrospective study, 64 consecutive pregnancies in 61 immunized women with anti-D titre ≥128 at any time during pregnancy were included...
October 11, 2018: Vox Sanguinis
Maria Didriksen, Klaus Rostgaard, Kirsten Grønbaek, Ole B Pedersen, Kjell Titlestad, Christian Erikstrup, Kaspar R Nielsen, Gustaf Edgren, Henrik Ullum, Henrik Hjalgrim
BACKGROUND AND OBJECTIVES: Chronic red-cell transfusions may be an indispensable part of patient treatment and may require early intervention to avoid adverse transfusion effects. The population of chronic transfusion recipients including common diagnoses and survival remains poorly characterised. Thus, the objective was to examine the complete range of chronic transfusion recipients, including demographic and patient characteristics and survival. MATERIALS AND METHODS: All patients who received their first transfusion in Sweden or Denmark from January 1, 2002 to December 31, 2010 were followed up for subsequent transfusion episodes until December 31, 2012...
September 30, 2018: Vox Sanguinis
Hideaki Matsuura, Yoshiki Akatsuka, Takahiro Matsuno, Yukari Sugiura, Shoko Arakawa, Shota Oikawa, Jumpei Yoshida, Mitsuaki Kosugi, Nobuhiko Emi
BACKGROUND AND OBJECTIVES: Determination of the anti-A/-B titre pre- and post-transplantation is beneficial for treatment selection. Currently, the recommended method for antibody titration is the tube test (TT) assay. Dithiothreitol (DTT) is used for IgM antibody inactivation. Recently, a fully automated antibody titration assay using the column agglutination technique (CAT) was developed (auto-CAT). Our aim was to compare the auto-CAT and TT techniques for ABO antibody titration, to evaluate the effectiveness of DTT-treated plasma for use with auto-CAT and to define the cut-off value for antibody titration by auto-CAT...
September 24, 2018: Vox Sanguinis
Judie Leach Bennett, Dana V Devine
Formal processes to assess risk are well established in numerous areas of society including the environment, transportation, energy and food production sectors as well as some areas of health care such as new drugs or other therapeutic goods. However, these processes and their associated frameworks have only recently come to be used to make decisions in blood transfusion practice or in blood system policy development. This review describes the evolution of the use of risk-based decision making and discusses the elements that should be considered in its application to blood system issues...
September 19, 2018: Vox Sanguinis
Lassina Barro, Victor J Drew, Ghislain G Poda, Claude T Tagny, Magdy El-Ekiaby, Shirley Owusu-Ofori, Thierry Burnouf
Blood transfusion in sub-Saharan Africa (SSA) is at a crossroad. Significant recent developments may help meet local needs in safe blood products and fulfil a global health target, as highlighted by the World Health Organization (WHO) Millennium and Sustainable Development Goals, in improving supply and safety, and ensuring the gradual implementation of selective haemotherapy. When WHO recommended the evaluation of convalescent blood or plasma to treat Ebola-infected patients during the recent epidemics, substantial gaps in local blood collection, testing and technology infrastructure and safety, as compared to best accepted quality standards, became evident...
September 16, 2018: Vox Sanguinis
Krzysztof Bartnik, Katarzyna Pruszczyk, Kamila Skwierawska, Małgorzata Król, Milena Płachta, Albert Moskowicz, Tomasz Zakrzewski, Elżbieta Urbanowska, Wiesław Wiktor Jędrzejczak, Emilian Snarski
BACKGROUND: Bone marrow harvest (BMH) for haematopoietic stem cell transplantation is a well-established procedure. The guidelines of World Marrow Donor Association provide information on donor selection. However, some of the guidelines regarding donors with anaemia prior to harvest lack in supporting data from clinical studies. With this study, we aimed to provide such data. MATERIAL AND METHODS: In this retrospective, single-centre study, we analysed the interplay between haemoglobin levels and BMH and BMH impact on haemoglobin levels in a cohort of 149 unrelated BM donors, including 13 subjects with mild anaemia...
September 6, 2018: Vox Sanguinis
Andres F Osorio, Sally C Brailsford, Honora K Smith, John Blake
BACKGROUND: The topology of the blood supply chain network can take different forms in different settings, depending on geography, politics, costs, etc. Many developed countries are moving towards centralized networks. The goal for all blood distribution networks, regardless of topology, remains the same: to satisfy demand at minimal cost and minimal wastage. STUDY DESIGN AND METHODS: Mathematically, the blood supply system design can be viewed as a location-allocation problem, where the aim is to find the optimal location of collection and production facilities and to assign hospitals to them to minimize total system cost...
September 4, 2018: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
October 2018: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
October 2018: Vox Sanguinis
Micah T Prochaska, Richard Newcomb, David Jiang, David O Meltzer
BACKGROUND AND OBJECTIVE: Guidelines suggest that red-blood-cell transfusion decisions for most hospitalized patients be based on haemoglobin (Hb) concentration and the presence of symptoms of anaemia, including fatigue. However, studies differ in whether transfusion is associated with improvements in fatigue. One explanation is that the benefit of transfusion varies by baseline fatigue levels, which existing studies have not examined. The objective of this study was to determine whether the association between transfusion during hospitalization and improvements in fatigue 30 days postdischarge varies by baseline fatigue level...
October 2018: Vox Sanguinis
Jillian A Patterson, Tanya A Nippita, Deborah Randall, David O Irving, Jane B Ford
BACKGROUND AND OBJECTIVES: Obstetric haemorrhage is associated with increased blood transfusion, morbidity and health service usage in women. While the use of transfusion in actively bleeding patients is supported, there is little evidence for the use of blood as treatment in the nonbleeding patient following obstetric haemorrhage. Transfusion may expose women to increased morbidity. This study aims to compare outcomes between low-risk women receiving no or 1-2 units of blood in the context of obstetric haemorrhage...
October 2018: Vox Sanguinis
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