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Vox Sanguinis

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https://www.readbyqxmd.com/read/29318636/a-multicentred-study-to-validate-a-consensus-bleeding-assessment-tool-developed-by-the-biomedical-excellence-for-safer-transfusion-collaborative-for-use-in-patients-with-haematological-malignancy
#1
C Dyer, C R Alquist, M Cole-Sinclair, E Curnow, N M Dunbar, L J Estcourt, R Kaufman, J M Kutner, J McCullough, Z McQuilten, L Potiphar, B Rioux-Masse, S Slichter, A Tinmouth, K Webert, A P Yokoyama, S J Stanworth
BACKGROUND: There continues to be uncertainty about the optimal approach to documenting bleeding data in platelet transfusion trials, with a desire to apply a common assessment tool across all trials. With this in mind, a consensus bleeding assessment tool (BAT) has been developed by the Biomedical Excellence for Safer Transfusion (BEST) collaborative, based on review of data collection forms used in published randomized trials and following content validation with a range of healthcare professionals at seven haematology centres through BEST members...
January 10, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29314064/worldwide-policies-on-epilepsy-and-blood-donation-a-survey-among-blood-services
#2
A Kellens, E De Buck, M-P Emonds, P Vandekerckhove, L Lagae
BACKGROUND AND OBJECTIVES: Epilepsy is a common neurological disorder characterized by the appearance of seizures. Often, epilepsy patients are temporarily or permanently excluded from blood donation. To gain a better understanding of the policies that are currently applied, we performed a survey among blood services. METHODS: A cross-sectional, Web-based questionnaire using the online Questback tool was developed and distributed to 46 representatives of blood services worldwide...
January 4, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29314033/amustaline-s-303-treatment-inactivates-high-levels-of-chikungunya-virus-in-red-blood-cell-components
#3
M Aubry, A Laughhunn, F Santa Maria, M C Lanteri, A Stassinopoulos, D Musso
BACKGROUND AND OBJECTIVES: Chikungunya virus (CHIKV) infections have been reported in all continents, and the potential risk for CHIKV transfusion-transmitted infections (TTIs) was demonstrated by the detection of CHIKV RNA-positive donations in several countries. TTIs can be reduced by pathogen inactivation (PI) of blood products. In this study, we evaluated the efficacy of amustaline and glutathione (S-303/GSH) to inactivate CHIKV in red-blood-cell concentrates (RBCs). MATERIAL AND METHODS: Red-blood-cells were spiked with high level of CHIKV...
January 4, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29282745/vox-sanguinis-international-forum-on-application-of-fetal-blood-grouping-summary
#4
LETTER
G Daniels, K Finning, M Lozano, C A Hyland, Y-W Liew, T Powley, L Castilho, C Bonet Bub, J M Kutner, F Banch Clausen, M Christiansen, K Sulin, K Haimila, T J Legler, M Lambert, H Ryan, S Ní Loingsigh, A Matteocci, L Pierelli, T Dovc Drnovsek, I Bricl, N Nogués, E Muñiz-Diaz, M L Olsson, A Wikman, M de Haas, C E van der Schoot, E Massey, C M Westhoff
No abstract text is available yet for this article.
December 28, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29282741/vox-sanguinis-international-forum-on-application-of-fetal-blood-grouping
#5
LETTER
G Daniels, K Finning, M Lozano, C A Hyland, Y-W Liew, T Powley, L Castilho, C Bonet Bub, J M Kutner, F Banch Clausen, M Christiansen, K Sulin, K Haimila, T J Legler, M Lambert, H Ryan, S Ní Loingsigh, A Matteocci, L Pierelli, T Dovc Drnovsek, I Bricl, N Nogués, E Muñiz-Diaz, M L Olsson, A Wikman, M de Haas, C E van der Schoot, E Massey, C M Westhoff
No abstract text is available yet for this article.
December 28, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29280152/silent-kel-alleles-identified-from-japanese-individuals-with-the-ko-phenotype
#6
T Onodera, M Kawai, K Obara, T Enomoto, K Sasaki, T Osabe, K Ogasawara, C Toyoda, H Tsuneyama, M Uchikawa, S Inaba, M Satake
BACKGROUND AND OBJECTIVE: The rare Ko phenotype lacks all 36 antigens in the Kell blood system. The molecular basis of the Ko phenotype has been investigated, and more than 40 silent KEL alleles are reported by many investigators. The majority of silent alleles are the KEL*02 background. Here, we report molecular genetic analysis of the KEL gene in Japanese individuals with the Ko phenotype. MATERIALS AND METHODS: The Ko phenotype was screened from Japanese blood donors for several years using monoclonal anti-Ku or anti-K14 by an automated blood grouping system PK7300...
December 27, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29277907/a-multicentre-study-investigating-vital-sign-changes-occurring-in-complicated-and-uncomplicated-transfusions
#7
E A Gehrie, N H Roubinian, D Chowdhury, D J Brambilla, E L Murphy, J L Gottschall, Y Wu, P M Ness, R G Strauss, J E Hendrickson
BACKGROUND AND OBJECTIVES: Many hospitals require transfusions to be discontinued when vital signs stray from predetermined ranges, regardless of clinical symptoms. Variations in vital signs may be unrelated to transfusion, however, and needlessly stopping a transfusion may delay medical care while increasing donor exposures and healthcare costs. We hypothesized that a detailed study of vital sign changes associated with transfusion of blood product by component, including those associated with potential reactions (complicated) and those deemed to be uncomplicated, would establish a useful framework of reference for treating clinicians and transfusion services alike...
December 25, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29266372/red-blood-cell-transfusion-support-and-management-of-secondary-iron-overload-in-patients-with-haematological-malignancies-in-the-netherlands-a-survey
#8
M P A Hoeks, R A Middelburg, B Romeijn, N M A Blijlevens, M G J van Kraaij, J J Zwaginga
BACKGROUND AND OBJECTIVES: Evidence-based guidelines on optimal triggers for red blood cell (RBC) transfusion in patients with haematological malignancies exist, but the evidence is weak. Secondary iron overload is an often overlooked chronic complication of RBC transfusions, and also here, guidelines are either lacking or lack international consensus. Our aim was to evaluate the triggers for RBC transfusion support and management of secondary iron overload among haematologists in the Netherlands...
December 19, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29243265/what-motivates-men-to-donate-blood-a-systematic-review-of-the-evidence
#9
REVIEW
A Carver, K Chell, T E Davison, B M Masser
BACKGROUND AND OBJECTIVES: Effective recruitment and retention of male donors are vital for the ongoing provision of blood products. Compared with females, male donors are less likely to be medically deferred or experience vasovagal reactions and are typically preferred for plasmapheresis donation in voluntary non-remunerated settings. However, females outnumber males among donors aged under 40 years. This systematic review aimed to synthesize evidence and identify key motivators for blood donation among males to inform targeted recruitment/retention campaigns...
December 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29243264/prolonged-platelet-storage-associated-with-increased-frequency-of-transfusion-related-adverse-events
#10
M Losos, E Biller, J Li, L Blower, D Hamad, G Patel, S Scrape, S Cataland, J Chen
BACKGROUND: Platelets (PLTs) have been associated with the highest rate of transfusion-associated adverse events (AEs) among all blood products. Most of PLT-associated AEs are considered to have an inflammatory mechanism. However, it is still unclear whether prolonged storage of platelets is associated with an increased rate of transfusion-related AEs, especially in the era of universal prestorage leucoreduction. METHODS/MATERIALS: In this retrospective study, 52 649 PLT products consisting of about 80% apheresis PLTs and 20% whole blood-derived (WBD) PLTs were transfused to 9415 patients from July 2011 to March 2017...
December 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29238993/donor-deferral-policies-for-men-who-have-sex-with-men-past-present-and-future
#11
REVIEW
M Goldman, A W-Y Shih, S F O'Brien, D Devine
We review the history and evolution of blood donor criteria for men who have sex with men (MSM). Deferral policies in many jurisdictions, including Australia, New Zealand, Canada, the United States, Brazil and many western European countries are based on a period of abstinence from MSM, often of 12 months duration. Several countries (Italy, Spain and Portugal) defer donors based on sexual behaviours considered to be at high risk, regardless of whether the partner is same sex or opposite sex. Compliance is a key determinant in the efficacy of any deferral policy...
December 13, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29238971/postauthorization-safety-study-of-clottafact%C3%A2-a-triply-secured-fibrinogen-concentrate-in-acquired-fibrinogen-deficiency-a-prospective-observational-study
#12
C Négrier, A-S Ducloy-Bouthors, V Piriou, E De Maistre, N Stieltjes, A Borel-Derlon, P Colson, J Picard, T Lambert, S Claeyssens, S Boileau, A Bertrand, M-H André, F Fourrier, Y Ozier, P Sié, Y Gruel, Z Tellier
BACKGROUND AND OBJECTIVES: A postauthorization safety study was performed between 2009 and 2012 to describe the use of Clottafact® in acquired fibrinogen deficiency in real-life medical practice in France. MATERIALS AND METHODS: One hundred and fifty patients were planned for 28 days of prospective follow-up after infusion. The analysis of this observational study was descriptive and performed according to the type of treatment (curative or preventive) and the origin of the bleed...
December 13, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29230833/causes-of-iron-overload-in-blood-donors-a-clinical-study
#13
A H Laursen, O W Bjerrum, L Friis-Hansen, T O Hansen, J L Marott, K Magnussen
BACKGROUND AND OBJECTIVES: Despite the obligate iron loss from blood donation, some donors present with hyperferritinaemia that can result from a wide range of acute and chronic conditions including hereditary haemochromatosis (HH). The objective of our study was to investigate the causes of hyperferritinaemia in the blood donor population and explore the value of extensive HH mutational analyses. MATERIALS AND METHODS: Forty-nine consecutive donors (f = 6, m = 43) were included prospectively from the Capital Regional Blood Center...
December 12, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29214632/thorough-analysis-of-unorthodox-abo-deletions-called-by-the-1000-genomes-project
#14
M Möller, Å Hellberg, M L Olsson
BACKGROUND AND OBJECTIVES: ABO remains the clinically most important blood group system, but despite earlier extensive research, significant findings are still being made. The vast majority of catalogued ABO null alleles are based on the c.261delG polymorphism. Apart from c.802G>A, other mechanisms for O alleles are rare. While analysing the data set from the 1000 Genomes (1000G) project, we encountered two previously uncharacterized deletions, which needed further exploration. MATERIALS AND METHODS: The Erythrogene database, complemented with bioinformatics software, was used to analyse ABO in 2504 individuals from 1000G...
December 6, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29193128/pathogen-reduction-and-blood-transfusion-safety-in-africa-strengths-limitations-and-challenges-of-implementation-in-low-resource-settings
#15
REVIEW
A D Ware, C Jacquot, A A R Tobian, E A Gehrie, P M Ness, E M Bloch
Transfusion-transmitted infection risk remains an enduring challenge to blood safety in Africa. A high background incidence and prevalence of the major transfusion-transmitted infections (TTIs), dependence on high-risk donors to meet demand, suboptimal testing and quality assurance collectively contribute to the increased risk. With few exceptions, donor testing is confined to serological evaluation of human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) and syphilis. Barriers to implementation of broader molecular methods include cost, limited infrastructure and lack of technical expertise...
November 30, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29124766/direct-costs-of-transfusion-reactions-an-expert-judgement-approach
#16
M P Janssen, A J W van Tilborgh, K M K de Vooght, A G Bokhorst, J C Wiersum-Osselton
BACKGROUND AND OBJECTIVES: Despite increasingly meticulous haemovigilance reporting throughout the world, a systematic assessment of the cost of transfusion reactions is still lacking. This is partly caused by the fact that such an assessment requires a subjective expert assessment of the additional costs linked to the adverse reaction. Data on the cost of transfusion reactions could support decision-making regarding blood transfusion safety measures. MATERIALS AND METHODS: Thirteen experts from nine hospitals were asked to estimate the additional care required following various types of transfusion reactions...
November 9, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29082579/scvo2-changes-after-red-blood-cell-transfusion-for-anaemia-in-cardiothoracic-and-vascular-icu-patients-an-observational-study
#17
N Zeroual, G Samarani, J Gallais, G Culas, M Saour, M Mourad, P Gaudard, P H Colson
BACKGROUND AND OBJECTIVES: Haemoglobin threshold for transfusion has been significantly decreased, but haemoglobin plasma concentration may not be sufficient to assess the need of red-blood-cell (RBC) transfusion. Central venous oxygen saturation (ScvO2 ) is a clue of metabolic matching between O2 transport and consumption, which could help to assess when transfusion is appropriate once anaemia has been diagnosed in ICU patients. MATERIALS AND METHODS: Adult patients admitted consecutively to a cardiothoracic and vascular ICU were included in a prospective, observational and single-centre study over a 6-month period (September 2014 to February 2015), provided they were transfused with RBC...
October 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29082529/patient-blood-management-knowledge-and-practice-among-clinicians-from-seven-european-university-hospitals-a%C3%A2-multicentre-survey
#18
P M Manzini, A M Dall'Omo, S D'Antico, A Valfrè, K Pendry, A Wikman, D Fischer, D Borg-Aquilina, S Laspina, E C M van Pampus, M van Kraaij, M T Bruun, J Georgsen, J Grant-Casey, P S Babra, M F Murphy, G Folléa, K Aranko
BACKGROUND AND OBJECTIVES: The aim of this survey was to evaluate the knowledge about Patient Blood Management (PBM) principles and practices amongst clinicians working in seven European hospitals participating in a European Blood Alliance (EBA) project. MATERIALS AND METHODS: A web-based questionnaire was sent to 4952 clinicians working in medical, surgery and anaesthesiology disciplines. The responses were analysed, and the overall results as well as a comparison between hospitals are presented...
October 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29076169/international-forum-on-gmp-grade-human-platelet-lysate-for-cell-propagation-summary
#19
LETTER
D Strunk, M Lozano, D C Marks, Y S Loh, G Gstraunthaler, H Schennach, E Rohde, S Laner-Plamberger, M Öller, J Nystedt, R Lotfi, M Rojewski, H Schrezenmeier, K Bieback, R Schäfer, T Bakchoul, M Waidmann, S M Jonsdottir-Buch, H Montazeri, O E Sigurjonsson, P Iudicone, D Fioravanti, L Pierelli, M Introna, C Capelli, A Falanga, M Takanashi, O Lόpez-Villar, T Burnouf, J A Reems, J Pierce, A M Preslar, K Schallmoser
No abstract text is available yet for this article.
October 26, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29071726/international-forum-on-gmp-grade-human-platelet-lysate-for-cell-propagation
#20
LETTER
D Strunk, M Lozano, D C Marks, Y S Loh, G Gstraunthaler, H Schennach, E Rohde, S Laner-Plamberger, M Öller, J Nystedt, R Lotfi, M Rojewski, H Schrezenmeier, K Bieback, R Schäfer, T Bakchoul, M Waidmann, S M Jonsdottir-Buch, H Montazeri, O E Sigurjonsson, P Iudicone, D Fioravanti, L Pierelli, M Introna, C Capelli, A Falanga, M Takanashi, O López-Villar, T Burnouf, J A Reems, J Pierce, A M Preslar, K Schallmoser
No abstract text is available yet for this article.
October 25, 2017: Vox Sanguinis
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