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Vox Sanguinis

A Holbro, T Volken, A Buser, J P Sigle, J P Halter, J R Passweg, A Tichelli, L Infanti
According to many textbooks, iron deficiency (ID) is associated with reactive thrombocytosis. In this study, we aimed to investigate the correlation between serum ferritin levels and platelet counts in a large cohort of healthy blood donors. We included all whole blood and apheresis donors aged 18 years or older with at least one ferritin measurement and one platelet count performed at the same visit between 1996 and 2014. A total of 130 345 blood counts and ferritin measurements obtained from 22 046 healthy donors were analysed...
November 21, 2016: Vox Sanguinis
P Owusu-Agyemang, U U Williams, A Van Meter, A M Zavala, E Rebello, L Feng, A Hayes-Jordan, J P Cata
BACKGROUND AND OBJECTIVES: Studies indicate the perioperative transfusion of red blood cells during oncologic surgery may be associated with worse outcomes. In this study, we evaluated the impact of red blood cell transfusions on the short- and long-term outcomes of children undergoing a major oncologic surgery. MATERIALS AND METHODS: A retrospective review of the medical records of children ≤18 years of age who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy was performed...
November 21, 2016: Vox Sanguinis
C Politis, J C Wiersum, C Richardson, P Robillard, J Jorgensen, P Renaudier, J-C Faber, E M Wood
BACKGROUND AND OBJECTIVES: The International Haemovigilance Network's ISTARE is an online database for surveillance of all adverse reactions (ARs) and adverse events (AEs) associated with donation of blood and transfusion of blood components, irrespective of severity or the harm caused. ISTARE aims to unify the collection and sharing of information with a view to harmonizing best practices for haemovigilance systems around the world. MATERIALS AND METHODS: Adverse reactionss and adverse events are recorded by blood component, type of reaction, severity and imputability to transfusion, using internationally agreed standard definitions...
September 22, 2016: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Vox Sanguinis
R Torres, C A Tormey
The aim of this study was to create a model of oxygen distribution within platelet storage bags to evaluate implications of reduced agitation approaches. Based on our model, platelet concentration and surface area most affect internal partial pressure of oxygen, while temperature modifications have least effect, indicating primary potential approaches for optimization of platelet storage with reduced or absent agitation.
November 2016: Vox Sanguinis
Y S Loh, S Tan, M Kwok, M J Stark, D C Marks
BACKGROUND: Washing of red blood cells (RBC) can reduce unwanted biological response modifiers (BRMs) that can mediate transfusion complications in infants. The aim of this study was to examine the in vitro quality and the changes in BRMs following washing in paediatric RBC units. MATERIALS AND METHODS: A pool and split design was used to prepare RBC (either 1 or 4 days old; n = 26 pairs). One unit was washed with 0·9% saline by centrifugation and then resuspended in SAG-M, while the other remained unwashed...
November 2016: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Vox Sanguinis
M H Seo, E J Won, Y J Hong, S Chun, J R Kwon, Y S Choi, J N Kim, S A Lee, A H Lim, S H Kim, K U Park, D Cho
BACKGROUND AND OBJECTIVES: The purpose of this study was to provide an effective RHD genotyping strategy for the East Asian blood donors. MATERIAL AND METHODS: RhD phenotyping, weak D testing and RhCE phenotyping were performed on 110 samples from members of the RhD-negative club, private organization composed of RhD-negative blood donors, in the GwangJu-Chonnam region of Korea. The RHD promoter, intron 4, and exons 7 and 10 were analysed by real-time PCR. Two nucleotide changes (c...
November 2016: Vox Sanguinis
J D Roback
BACKGROUND & OBJECTIVES: Red blood cells (RBCs) may be stored up to 42 days before transfusion, per US and EU standards. Although there is ample evidence that RBCs undergo deleterious changes during storage, studies assessing outcomes relative to storage time report conflicting findings. This study investigated RBC storage duration perspectives and practices among blood banking and transfusion professionals. MATERIALS & METHODS: A survey was administered at the American Association of Blood Banking annual meeting in October 2014 (N = 69)...
November 2016: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Vox Sanguinis
V M A Voorn, A van der Hout, C So-Osman, T P M Vliet Vlieland, R G H H Nelissen, M E van den Akker-van Marle, A Dahan, P J Marang-van de Mheen, L van Bodegom-Vos
BACKGROUND AND OBJECTIVES: To determine the value of erythropoietin in reducing allogeneic transfusions, it is important to assess the effects, safety and costs for individual indications. Previous studies neither compared the effects of erythropoietin between total hip and total knee arthroplasty, nor evaluated the safety or costs. We performed a meta-analysis to assess the effects of erythropoietin in total hip and knee arthroplasty separately. Safety and costs were evaluated as secondary outcomes...
October 2016: Vox Sanguinis
A S de Vos, R W Lieshout-Krikke, E Slot, E A Cator, M P Janssen
BACKGROUND AND OBJECTIVES: Individuals may donate blood in order to determine their infection status after exposure to an increased infection risk. Such test-seeking behaviour decreases transfusion safety. Instances of test seeking are difficult to substantiate as donors are unlikely to admit to such behaviour. However, manifestation in a population of repeat donors may be determined using statistical inference. MATERIALS AND METHODS: Test-seeking donors would be highly motivated to donate following infection risk, influencing the timing of their donation...
October 2016: Vox Sanguinis
H M Faddy, J J Fryk, D Watterson, P R Young, N Modhiran, D A Muller, S D Keil, R P Goodrich, D C Marks
BACKGROUND: Dengue viruses (DENV 1-4) are emerging across the world, and these viruses pose a risk to transfusion safety. Pathogen inactivation may be an alternative approach for managing the risk of DENV transfusion transmission. This study aimed to investigate the ability of riboflavin and UV light to inactivate DENV 1-4 in platelet concentrates. MATERIALS AND METHODS: DENV 1-4 were spiked into buffy coat-derived platelet concentrates in additive solution (SSP+) before being treated with riboflavin and UV light...
October 2016: Vox Sanguinis
T Minagi, H Okamoto, M Ikegawa, S Ideno, K Takahashi, K Sakai, K Hagiwara, M Yunoki, A Wakisaka
BACKGROUND AND OBJECTIVES: Human hepatitis E virus (HEV) is prevalent worldwide. Iatrogenic HEV has recently been identified based on the reports of transfusion-transmitted cases. The detection rate of HEV-RNA and seroprevalence of HEV-IgG/IgM have been regionally evaluated in Japan, and donor plasma collected in Hokkaido is currently screened by nucleic acid amplification testing. However, the detection rate of HEV-RNA in blood donors in Japan outside of Hokkaido has not been reported...
October 2016: Vox Sanguinis
C K Okerberg, L A Williams, M L Kilgore, C H Kim, M B Marques, J Schwartz, H P Pham
BACKGROUND: Fibrinogen repletion in patients with acquired bleeding disorders can be accomplished by transfusing cryoprecipitate AHF (cryo) or fibrinogen concentrate (FC); thus, we undertook an economic evaluation from the transfusion service perspective regarding the use of cryo vs. FC in patients with acquired bleeding. METHODS: We created a model comparing the cost of cryo vs. FC from the transfusion service perspective. A patient with acquired bleeding requiring fibrinogen replacement could receive either 15-20 cryo units or 3-4 g FC, consistent with the guidelines from the European Task Force for Advanced Bleeding Care in Trauma...
October 2016: Vox Sanguinis
D Narbey, A-M Fillet, S Jbilou, P Tiberghien, R Djoudi
BACKGROUND AND OBJECTIVE(S): Vasovagal reactions (VVRs) are the most common adverse events associated with blood donations. To assess the relative importance of VVR risk factors, a retrospective case-control study of severe immediate and delayed VVRs was performed. STUDY DESIGN: Vasovagal reactions were defined as immediate when occurring at the transfusion site and as delayed when occurring outside the transfusion site and within 24 h following donation. VVRs with probable or certain imputability and moderate to death severity were considered...
October 2016: Vox Sanguinis
L Wei, Z G Shan, R L Flower, Z Wang, J Z Wen, G P Luo, Y L Ji
BACKGROUND AND OBJECTIVES: MNS hybrid glycophorins are identified by characteristic antigen profiles. One of these is the Mur antigen, which is expressed on red cell hybrid glycophorins of several phenotypes of the 'Miltenberger' series found predominantly in East Asian population. The aim of this study was to investigate the distribution of Mur-positive hybrid glycophorins and clarify the genetic basis in the donors from southern China. MATERIALS AND METHODS: Blood samples from 528 donors were collected for Mur antigen serological typing...
October 2016: Vox Sanguinis
A Heger, S Janisch, K Pock, J Römisch
BACKGROUND AND OBJECTIVES: The solvent/detergent treatment enables effective and robust inactivation of all lipid-enveloped viruses, but also inactivates partly sensitive plasma proteins such as protein S. The aim of this study was to investigate the thrombin generation capacity of octaplasLG(®) , in particular focusing on the function of protein S in thrombin generation assay and the impact of assay settings. MATERIALS AND METHODS: Sixteen octaplasLG(®) batches and 32 units of single donor fresh frozen plasma (FFP) were investigated...
October 2016: Vox Sanguinis
Z Solh, U Athale, D M Arnold, R J Cook, R Foley, N M Heddle
BACKGROUND & OBJECTIVES: Alloimmunization rates following red blood cell (RBC) transfusion in paediatric oncology are not known. This study aimed to: (1) describe frequency and specificity of alloantibodies in paediatric oncology patients after RBC transfusions; (2) determine the effect of chemotherapy on alloimmunization rate. MATERIALS & METHODS: Retrospective cohort study of paediatric patients at a tertiary care hospital is evaluated by two groups: control group, paediatric patients without cancer; study group, paediatric oncology patients who received chemotherapy...
October 2016: Vox Sanguinis
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