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Vox Sanguinis

Judie Leach Bennett, Dana V Devine
Formal processes to assess risk are well established in numerous areas of society including the environment, transportation, energy and food production sectors as well as some areas of health care such as new drugs or other therapeutic goods. However, these processes and their associated frameworks have only recently come to be used to make decisions in blood transfusion practice or in blood system policy development. This review describes the evolution of the use of risk-based decision making and discusses the elements that should be considered in its application to blood system issues...
September 19, 2018: Vox Sanguinis
Lassina Barro, Victor J Drew, Ghislain G Poda, Claude T Tagny, Magdy El-Ekiaby, Shirley Owusu-Ofori, Thierry Burnouf
Blood transfusion in sub-Saharan Africa (SSA) is at a crossroad. Significant recent developments may help meet local needs in safe blood products and fulfil a global health target, as highlighted by the World Health Organization (WHO) Millennium and Sustainable Development Goals, in improving supply and safety, and ensuring the gradual implementation of selective haemotherapy. When WHO recommended the evaluation of convalescent blood or plasma to treat Ebola-infected patients during the recent epidemics, substantial gaps in local blood collection, testing and technology infrastructure and safety, as compared to best accepted quality standards, became evident...
September 16, 2018: Vox Sanguinis
Krzysztof Bartnik, Katarzyna Pruszczyk, Kamila Skwierawska, Małgorzata Król, Milena Płachta, Albert Moskowicz, Tomasz Zakrzewski, Elżbieta Urbanowska, Wiesław Wiktor Jędrzejczak, Emilian Snarski
BACKGROUND: Bone marrow harvest (BMH) for haematopoietic stem cell transplantation is a well-established procedure. The guidelines of World Marrow Donor Association provide information on donor selection. However, some of the guidelines regarding donors with anaemia prior to harvest lack in supporting data from clinical studies. With this study, we aimed to provide such data. MATERIAL AND METHODS: In this retrospective, single-centre study, we analysed the interplay between haemoglobin levels and BMH and BMH impact on haemoglobin levels in a cohort of 149 unrelated BM donors, including 13 subjects with mild anaemia...
September 6, 2018: Vox Sanguinis
Micah T Prochaska, Richard Newcomb, David Jiang, David O Meltzer
BACKGROUND AND OBJECTIVE: Guidelines suggest that red-blood-cell transfusion decisions for most hospitalized patients be based on haemoglobin (Hb) concentration and the presence of symptoms of anaemia, including fatigue. However, studies differ in whether transfusion is associated with improvements in fatigue. One explanation is that the benefit of transfusion varies by baseline fatigue levels, which existing studies have not examined. The objective of this study was to determine whether the association between transfusion during hospitalization and improvements in fatigue 30 days postdischarge varies by baseline fatigue level...
September 4, 2018: Vox Sanguinis
Andres F Osorio, Sally C Brailsford, Honora K Smith, John Blake
BACKGROUND: The topology of the blood supply chain network can take different forms in different settings, depending on geography, politics, costs, etc. Many developed countries are moving towards centralized networks. The goal for all blood distribution networks, regardless of topology, remains the same: to satisfy demand at minimal cost and minimal wastage. STUDY DESIGN AND METHODS: Mathematically, the blood supply system design can be viewed as a location-allocation problem, where the aim is to find the optimal location of collection and production facilities and to assign hospitals to them to minimize total system cost...
September 4, 2018: Vox Sanguinis
Jillian A Patterson, Tanya A Nippita, Deborah Randall, David O Irving, Jane B Ford
BACKGROUND AND OBJECTIVES: Obstetric haemorrhage is associated with increased blood transfusion, morbidity and health service usage in women. While the use of transfusion in actively bleeding patients is supported, there is little evidence for the use of blood as treatment in the nonbleeding patient following obstetric haemorrhage. Transfusion may expose women to increased morbidity. This study aims to compare outcomes between low-risk women receiving no or 1-2 units of blood in the context of obstetric haemorrhage...
August 29, 2018: Vox Sanguinis
Øystein Wendelbo, Elin Netland Opheim, Tor Hervig, Turid Helen Felli Lunde, Øystein Bruserud, Tom Eirik Mollnes, Håkon Reikvam
BACKGROUND AND OBJECTIVES: In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red-blood-cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post-transfusion haemoglobin increment in patients with haematological diseases. MATERIALS AND METHODS: Twenty-seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study...
August 29, 2018: Vox Sanguinis
S Ohlsson, B Diedrich, M Uhlin, P Sandgren
BACKGROUND AND OBJECTIVE: Efficient pathogen inactivation (PI) offers the possibility of increasing the number of buffy coats per pool without the concurrent increased risk of pathogen transmission. Here, we describe the findings of in vitro analyses of platelets from pools of eight buffy coats treated with amotosalen and UVA light (INTERCEPT Blood System for Platelets) using INTERCEPT disposable processing sets with plastic materials sourced from alternate suppliers and split afterwards to obtain two therapeutic transfusion doses...
August 29, 2018: Vox Sanguinis
M H Yazer, P C Spinella, S Allard, D Roxby, C So-Osman, M Lozano, K Gunn, A W-Y Shih, J Stensballe, P I Johansson, M Bagge Hansen, M Maegele, H Doughty, N Crombie, D H Jenkins, A McGinity, R M Schaefer, C Martinaud, E Shinar, R Strugo, J Chen, H Russcher
No abstract text is available yet for this article.
August 24, 2018: Vox Sanguinis
Claude T Tagny, Syria Laperche, Edward L Murphy
BACKGROUND AND OBJECTIVES: The Francophone Africa Transfusion Research Network conducted the first large and comprehensive surveys on the status of blood safety in francophone African countries in 2009 and 2012. Since then, there has been substantial investment in blood safety but little is known about progress made in the region. MATERIALS AND METHODS: This multicentre cross-sectional study describes characteristics of blood services, donors and blood products and compares results with previous data...
August 19, 2018: Vox Sanguinis
Araitz Molano, Izaskun Apraiz, Patricia España, Maria Azkarate, Miguel Ángel Vesga, Montserrat Rubia, Mercedes Piedrabuena, Fernando Puente, Barbera Veldhuisen, Ellen van der Schoot, Diego Tejedor, Mónica López
BACKGROUND AND OBJECTIVES: Routine serologic D typing does not distinguish between weak D subtypes and partial D phenotypes. The goal of this study was to validate the performance of the ID RHD XT genotyping assay. MATERIAL AND METHODS: Previously serotyped samples for D antigen (n = 1000; 16% weak D serotyped donors) were analysed. The reference methods used for comparison were licensed serology tests for D antigen phenotype, and bidirectional sequencing (BDS) for weak D type confirmation and HPA-1 phenotype prediction...
August 19, 2018: Vox Sanguinis
Aseem K Tiwari, Gunjan Bhardwaj, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Ravi C Dara, Ritesh Sachdev, Arun Raizada, Monisha Sethi
BACKGROUND: It is important to detect Latent Iron Deficiency (LID) to prevent development of an overt iron deficiency anemia. Early detection is difficult by using conventional hematological and biochemical parameters. Soluble transferrin receptor (sTfR) is presently the gold standard for diagnosing LID. We evaluated the utility of Reticulocyte Hemoglobin Equivalent (Ret-He), a newer hematological parameter, to predict LID in blood donors as compared to sTfR. METHODS: This was a randomized prospective study performed on 501 donor samples over a period of three-months...
August 12, 2018: Vox Sanguinis
Fredrik Toss, Gustaf Edgren, Gösta Berlin, Bernd Stegmayr, Volker Witt
BACKGROUND AND OBJECTIVES: Symptomatic hypocalcaemia is common during apheresis procedures based on citrate-based anticoagulants. As a consequence, patients often receive prophylactic calcium treatment. However, a recent publication based on the World Apheresis Association (WAA) register suggested harmful effects of such prophylactic calcium use. Recognizing possible limitations in the previous WAA register analyses, we critically re-evaluate the data, to test whether a change in prophylactic calcium usage may be warranted...
August 6, 2018: Vox Sanguinis
Catherine Ravanat, Arnaud Dupuis, Nadine Marpaux, Christian Naegelen, Guillaume Mourey, Herve Isola, Michel Laforêt, Pascal Morel, Christian Gachet
BACKGROUND AND OBJECTIVES: Small batch-pooled (mini-pool) whole blood (WB)-derived plasma could be an alternative cost-effective source of therapeutic plasma (TP), but carries an increased risk of transfusion-transmitted infection due to exposure of the recipient to several donors. This risk can be mitigated by inactivation of pathogens susceptible to the amotosalen-UVA (AUVA)-treatment. We evaluated the conservation of coagulation factors in AUVA-plasma prepared from WB stored overnight under routine operating conditions, to determine its therapeutic efficacy...
August 6, 2018: Vox Sanguinis
Henriette Lorenzen, Nazia Lone Akhtar, Maria Nielsen, Lea Svendsen, Pernille Andersen
BACKGROUND AND OBJECTIVES: Daratumumab binds CD38 on red blood cells causing interference with indirect antiglobulin tests. Dithiothreitol is used to eliminate interference allowing detection of alloantibodies. Haemolysis is observed during storage of dithiothreitol-treated antibody identification panel cells. The objective of this study was to develop a modified method for dithiothreitol treatment to reduce the haemolysis during 33 days of storage and still be able to eliminate daratumumab interference...
July 25, 2018: Vox Sanguinis
Francisco Brito, Samuel Cordey, Eric Delwart, Xutao Deng, Diderik Tirefort, Coralie Lemoine-Chaduc, Evgeny Zdobnov, Thomas Lecompte, Laurent Kaiser, Sophie Waldvogel-Abramowski, Olivier Preynat-Seauve
BACKGROUND AND OBJECTIVES: Platelet concentrates are frequently transfused to patients with reduced immunity. An exhaustive description of their viral content is needed to prevent unwanted infection. MATERIAL AND METHODS: To track viral sequences, a shotgun metagenomics approach was used on a bank of 300 platelets concentrates. Sequences were analysed through the diagnostics-oriented pipeline ezVIR. RESULTS: We only observed viruses commonly described in healthy individuals...
July 18, 2018: Vox Sanguinis
M J Kim, J Y Shin, J A Oh, K E Jeong, Y S Choi, Q Park, M S Song, D H Lee
BACKGROUND AND OBJECTIVES: Despite safety measures to minimize the risk of transfusion-transmitted infections, a residual risk remains. To trace and review some such cases, we ask donors to notify the blood centre if they are diagnosed with an infection after they donate blood. MATERIALS AND METHODS: We analysed all data on postdonation cases of hepatitis A reported between 2007 and 2012. Archived specimens from these donors were tested for hepatitis A virus (HAV) using anti-HAV IgM/IgG and HAV-PCR as markers...
July 13, 2018: Vox Sanguinis
Y Ying, X Hong, X Xu, K Ma, J He, F Zhu
BACKGROUND: An erythroid cell-specific regulatory element (+5·8-kb) in the first intron of ABO is responsible for the antigen differential expression and the regulatory activity of the element was affected by the nucleotide mutation in the +5·8-kb region. Currently, many individuals with ABO subgroups were found in the Chinese population, but there was little information about the function of +5·8-kb region in these individuals. Here, we studied the mechanism of the mutation in the +5·8-kb region responsible for reducing of antigen expression in 30 ABO subtype Chinese individuals without mutation in the coding region or splicing site...
July 5, 2018: Vox Sanguinis
Philip Kiely, Veronica C Hoad, Erica M Wood
False positive (FP) viral marker results in blood donors continue to pose many challenges. Informing donors of FP results and subsequent deferral can result in stress and anxiety for donors and additional complexity and workload for blood services. Donor management strategies need to balance the requirement to minimise donor anxiety and inconvenience while maintaining sufficiency of supply. Decisions about how and when to inform donors of FP results and determine deferral periods can be difficult as FP results, while often transitory, can take up to several years to resolve...
July 4, 2018: Vox Sanguinis
G Enten, P Dalvi, N Martini, K Kausch, A Gray, M Landrigan, D Mangar, E Camporesi
BACKGROUND AND OBJECTIVES: During storage, red blood cells (RBCs) undergo physicochemical changes which affect the quality, function, and in vivo survival of transfused packed RBCs (pRBC). Changes include decreased 2,3-diphosphoglycerate (2,3-DPG) levels, decreased ATP, changes in mechanical properties and oxidative injury. RBC rejuvenation is a method used to increase levels of 2,3-DPG and ATP in pRBCs. This process requires incubating the pRBCs with a rejuvenation solution and subsequent washing...
July 3, 2018: Vox Sanguinis
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