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Vox Sanguinis

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https://www.readbyqxmd.com/read/29124766/direct-costs-of-transfusion-reactions-an-expert-judgement-approach
#1
M P Janssen, A J W van Tilborgh, K M K de Vooght, A G Bokhorst, J C Wiersum-Osselton
BACKGROUND AND OBJECTIVES: Despite increasingly meticulous haemovigilance reporting throughout the world, a systematic assessment of the cost of transfusion reactions is still lacking. This is partly caused by the fact that such an assessment requires a subjective expert assessment of the additional costs linked to the adverse reaction. Data on the cost of transfusion reactions could support decision-making regarding blood transfusion safety measures. MATERIALS AND METHODS: Thirteen experts from nine hospitals were asked to estimate the additional care required following various types of transfusion reactions...
November 9, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29082579/scvo2-changes-after-red-blood-cell-transfusion-for-anaemia-in-cardiothoracic-and-vascular-icu-patients-an-observational-study
#2
N Zeroual, G Samarani, J Gallais, G Culas, M Saour, M Mourad, P Gaudard, P H Colson
BACKGROUND AND OBJECTIVES: Haemoglobin threshold for transfusion has been significantly decreased, but haemoglobin plasma concentration may not be sufficient to assess the need of red-blood-cell (RBC) transfusion. Central venous oxygen saturation (ScvO2 ) is a clue of metabolic matching between O2 transport and consumption, which could help to assess when transfusion is appropriate once anaemia has been diagnosed in ICU patients. MATERIALS AND METHODS: Adult patients admitted consecutively to a cardiothoracic and vascular ICU were included in a prospective, observational and single-centre study over a 6-month period (September 2014 to February 2015), provided they were transfused with RBC...
October 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29082529/patient-blood-management-knowledge-and-practice-among-clinicians-from-seven-european-university-hospitals-a%C3%A2-multicentre-survey
#3
P M Manzini, A M Dall'Omo, S D'Antico, A Valfrè, K Pendry, A Wikman, D Fischer, D Borg-Aquilina, S Laspina, E C M van Pampus, M van Kraaij, M T Bruun, J Georgsen, J Grant-Casey, P S Babra, M F Murphy, G Folléa, K Aranko
BACKGROUND AND OBJECTIVES: The aim of this survey was to evaluate the knowledge about Patient Blood Management (PBM) principles and practices amongst clinicians working in seven European hospitals participating in a European Blood Alliance (EBA) project. MATERIALS AND METHODS: A web-based questionnaire was sent to 4952 clinicians working in medical, surgery and anaesthesiology disciplines. The responses were analysed, and the overall results as well as a comparison between hospitals are presented...
October 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29076169/international-forum-on-gmp-grade-human-platelet-lysate-for-cell-propagation-summary
#4
LETTER
D Strunk, M Lozano, D C Marks, Y S Loh, G Gstraunthaler, H Schennach, E Rohde, S Laner-Plamberger, M Öller, J Nystedt, R Lotfi, M Rojewski, H Schrezenmeier, K Bieback, R Schäfer, T Bakchoul, M Waidmann, S M Jonsdottir-Buch, H Montazeri, O E Sigurjonsson, P Iudicone, D Fioravanti, L Pierelli, M Introna, C Capelli, A Falanga, M Takanashi, O Lόpez-Villar, T Burnouf, J A Reems, J Pierce, A M Preslar, K Schallmoser
No abstract text is available yet for this article.
October 26, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29071726/international-forum-on-gmp-grade-human-platelet-lysate-for-cell-propagation
#5
LETTER
D Strunk, M Lozano, D C Marks, Y S Loh, G Gstraunthaler, H Schennach, E Rohde, S Laner-Plamberger, M Öller, J Nystedt, R Lotfi, M Rojewski, H Schrezenmeier, K Bieback, R Schäfer, T Bakchoul, M Waidmann, S M Jonsdottir-Buch, H Montazeri, O E Sigurjonsson, P Iudicone, D Fioravanti, L Pierelli, M Introna, C Capelli, A Falanga, M Takanashi, O López-Villar, T Burnouf, J A Reems, J Pierce, A M Preslar, K Schallmoser
No abstract text is available yet for this article.
October 25, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29067695/towards-bedside-washing-of-stored-red-blood-cells-a-prototype-of-a-simple-apparatus-based-on-microscale-sedimentation-in-normal-gravity
#6
G Khanal, R A Huynh, K Torabian, H Xia, E Vörös, S S Shevkoplyas
BACKGROUND AND OBJECTIVES: Infusion of by-products of red blood cell (RBC) storage-induced degradation as well as of the residual plasma proteins and the anticoagulant-preservative solution contained in units of stored blood serve no therapeutic purpose and may be harmful to some patients. Here, we describe a prototype of a gravity-driven system for bedside washing of stored RBCs. MATERIALS AND METHODS: Stored RBCs were diluted to 10% haematocrit (Hct) with normal saline, matching the conventional washing procedure...
October 25, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29067694/administration-of-platelet-concentrates-suspended-in-bicarbonated-ringer-s-solution-in-children-who-had-platelet-transfusion-reactions
#7
J Kobayashi, R Yanagisawa, T Ono, Y Tatsuzawa, Y Tokutake, N Kubota, E Hidaka, K Sakashita, S Kojima, S Shimodaira, T Nakamura
BACKGROUND AND OBJECTIVES: Adverse reactions to platelet transfusions are a problem. Children with primary haematological and malignant diseases may experience allergic transfusion reactions (ATRs) to platelet concentrates (PCs), which can be prevented by giving washed PCs. A new platelet additive solution, using bicarbonated Ringer's solution and acid-citrate-dextrose formula A (BRS-A), may be better for platelet washing and storage, but clinical data are scarce. MATERIALS AND METHODS: A retrospective cohort study for consecutive cases was performed between 2013 and 2017...
October 25, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29052242/emerging-infectious-disease-outbreaks-estimating-disease-risk-in-australian-blood-donors-travelling-overseas
#8
A Coghlan, V C Hoad, C R Seed, R Lp Flower, R J Harley, D Herbert, H M Faddy
BACKGROUND AND OBJECTIVES: International travel assists spread of infectious pathogens. Australians regularly travel to South-eastern Asia and the isles of the South Pacific, where they may become infected with infectious agents, such as dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses that pose a potential risk to transfusion safety. In Australia, donors are temporarily restricted from donating for fresh component manufacture following travel to many countries, including those in this study...
October 19, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29052231/audit-of-appropriate-use-of-platelet-transfusions-validation-of-adjudication-criteria
#9
M Etchells, J Spradbrow, R Cohen, Y Lin, C Armali, L Lieberman, C Cserti-Gazdewich, J Pendergrast, J Callum
BACKGROUND AND OBJECTIVES: Platelet (PLT) transfusions must be used appropriately, as they are in chronic short supply, costly and risky to patients. The goals of this audit were to: (1) validate preset adjudication criteria through an audit of appropriateness at four large academic hospitals; (2) identify variability in appropriateness across medical services, physician specialties or hospital locations; and (3) inform logistical or educational interventions that may reduce inappropriate use...
October 19, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29044674/haem-is-associated-with-thrombosis-in-neonates-and-infants-undergoing-cardiac-surgery-for-congenital-heart-disease
#10
M Stolla, K Henrichs, J M Cholette, A P Pietropaoli, R P Phipps, S L Spinelli, N Blumberg
BACKGROUND: Haem levels are associated with thrombosis in a variety of diseases, as well as being a contributing cause of thrombotic events in animal models. MATERIALS AND METHODS: We retrospectively analyzed samples from 39 children who underwent cardiac surgery with cardiopulmonary bypass, including 15 children who developed a postoperative thrombosis and 24 controls. RESULTS: Patients who developed thrombosis postoperatively had statistically significant higher average haem levels over time (presurgery to 12 h postsurgery) compared to patients who did not develop thrombosis...
October 16, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29044588/a-uniform-method-for-the-simultaneous-blood-group-phenotyping-of-fy-a-fy-b-jk-a-jk-b-s-s%C3%AC-p1-k-applying-lateral-flow-technique
#11
A Caesar, S Meyer, N Trost, K Neuenschwander, C Geisen, B M Frey, C Gassner, P Schwind
BACKGROUND AND OBJECTIVES: A lateral flow assay for simultaneous blood group typing of ABO, RhD, C, E, c, e, Cw and K with stable end-point and without centrifugation is in routine use since several years (MDmulticard(®) ). The typing of extended phenotype parameters belonging to the Duffy, Kidd, MNSs blood group systems and others, however, has not yet been demonstrated for this technique. Reliable detection of Fy(x) , a weak Fy(b) phenotype with a pronounced quantitative reduction of the number of Fy(b) antigens on the erythrocyte surface, remains a weakness of current serological blood grouping techniques...
October 16, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29034478/obituary-prof-johannes-joseph-van-rood-1926-2017
#12
A Brand, F H J Claas, R E Bontrop, R R P de Vries
No abstract text is available yet for this article.
October 16, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29023857/preceding-haemorrhagic-shock-as-a-detrimental-risk-factor-for-respiratory-distress-after-excessive-allogeneic-blood-transfusion
#13
R Masuda, T Iijima, R Kondo, Y Itoda, M Matsuhashi, S Hashimoto, T Kohira, N Kobayashi, H Okazaki
BACKGROUND AND OBJECTIVES: Whether transfusion-associated circulatory overload arises as a simple result of over-transfusion or requires another trigger remains unclear. Here, we examined whether respiratory distress could be reproduced by massive transfusion alone in an animal model. MATERIALS AND METHODS: A total of 20 anaesthetized swine were equipped with monitors. Allogeneic blood was obtained from 10 donor swine. A 4-stage loading protocol with each stage equivalent to 25% of the blood volume (BV) in the recipient swine was then used to infuse crystalloid (CR), hydroxyethyl starch (HES) or allogeneic blood (TR) (n = 5 each)...
October 11, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29023768/changes-in-circulating-inflammatory-markers-following-febrile-non-haemolytic-transfusion-reactions-to-leucoreduced-red-cells
#14
R Larsen, N Sandhu, N H H Heegaard, H Ullum, J H von Stemann, E Sørensen, D S Nellemann, M B Hansen
It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically...
October 11, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28990201/correlation-between-plasma-fibrinogen-and-fibtem-thromboelastometry-during-liver-transplantation-a-comprehensive-assessment
#15
A Blasi, A Sabate, J Beltran, M Costa, R Reyes, F Torres
BACKGROUND: Thromboelastometry may reduce red blood cell (RBC) transfusion in liver transplantation (LT). Fibrinogen concentration is a primary determinant of FIBTEM maximum clot firmness (MCF), but several factors could affect the correlation between FIBTEM MCF and fibrinogen values. We aimed to investigate (1) the concordance between fibrinogen level and FIBTEM MCF and (2) the association of fibrinogen level and FIBTEM MCF with RBC transfusion during LT. METHODS: A post hoc analysis of data from a randomized, multicentre, double-blind, saline/fibrinogen trial was used (NCT01539057)...
October 8, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28983930/safety-of-leucodepleted-salvaged-blood-in-oncological-surgery-an-in-vitro-model
#16
C Marraccini, L Merolle, P Berni, K Boito, I Tamagnini, E Kuhn, M Ragazzi, R Baricchi, T A Pertinhez
Intra-operative blood cell salvage (IOCS) is mainly avoided in onco surgery due to the suspicion that it could increase metastasis' risk. We simulated IOCS followed by leucodepletion: HCT116 (human colorectal cancer) cells were inoculated into packed red blood cells units, and their distribution was evaluated, step-by-step, by flow cytometry and immunohistochemistry. Most of HCT116 cells were lost during washing, and almost completely removed after filtration. IOCS plus leucodepletion could be of great advantage for oncological patients, where allogenic blood transfusion could influence tumour progression...
October 6, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28967676/evaluation-of-droplet-digital-pcr-for-quantification-of-residual-leucocytes-in-red-blood-cell-concentrates
#17
A Doescher, U Loges, E K Petershofen, T H Müller
BACKGROUND AND OBJECTIVES: Enumeration of residual white blood cells in leucoreduced blood components is essential part of quality control. Digital PCR has substantially facilitated quantitative PCR and was thus evaluated for measurements of leucocytes. MATERIALS AND METHODS: Target for quantification of leucocytes by digital droplet PCR was the blood group gene RHCE. The SPEF1 gene was added as internal control for the entire assay starting with automated DNA extraction...
October 2, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28960383/agonist-induced-platelet-reactivity-correlates-with-bleeding-in-haemato-oncological-patients
#18
B Batman, E R van Bladel, M van Hamersveld, P C M Pasker-de Jong, S J A Korporaal, R T Urbanus, M Roest, L A Boven, R Fijnheer
BACKGROUND AND OBJECTIVE: Prophylactic platelet transfusions are administered to prevent bleeding in haemato-oncological patients. However, bleeding still occurs, despite these transfusions. This practice is costly and not without risk. Better predictors of bleeding are needed, and flow cytometric evaluation of platelet function might aid the clinician in identifying patients at risk of bleeding. This evaluation can be performed within the hour and is not hampered by low platelet count...
September 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28960314/novel-intronic-rhd-variants-identified-in-serologically-d-negative-blood-donors
#19
M El Wafi, H El Housse, N Zaid, S Zouine, N Nourichafi, K Bouisk, M Benajiba, N Habti
BACKGROUND: Blood group genotyping is used to predict RhD phenotype in transfusion and obstetric medicine. Prediction of antigen D is based on molecular techniques which targets most common RHD-specific polymorphism. However, inactive RHD variants can suggest false-positive RhD phenotype. Their types and frequencies vary among ethnicities. Our study aimed to identify RHD variants among Moroccan blood donors who are serologically D negative. STUDY DESIGN AND METHODS: DNA from 53 blood donors who are serologically D negative RhC and/or RhE positive were screened for RHD exon 10 by PCR-SSP...
September 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28960367/enlargement-of-the-who-international-repository-for-platelet-transfusion-relevant-bacteria-reference-strains
#20
E Spindler-Raffel, R J Benjamin, C P McDonald, S Ramirez-Arcos, K Aplin, I Bekeredjian-Ding, D de Korte, C Gabriel, B Gathof, K-M Hanschmann, K Hourfar, C Ingram, M R Jacobs, S D Keil, Y Kou, B Lambrecht, J Marcelis, Z Mukhtar, H Nagumo, T Niekerk, J Rojo, S Marschner, M Satake, A Seltsam, E Seifried, S Sharafat, M Störmer, S Süßner, S J Wagner, R Yomtovian
BACKGROUND AND OBJECTIVES: Interventions to prevent and detect bacterial contamination of platelet concentrates (PCs) have reduced, but not eliminated the sepsis risk. Standardized bacterial strains are needed to validate detection and pathogen reduction technologies in PCs. Following the establishment of the First International Reference Repository of Platelet Transfusion-Relevant Bacterial Reference Strains (the 'repository'), the World Health Organization (WHO) Expert Committee on Biological Standardisation (ECBS) endorsed further repository expansion...
September 27, 2017: Vox Sanguinis
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