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Vox Sanguinis

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https://www.readbyqxmd.com/read/28332214/serum-eye-drops-a-survey-of-international-production-methods
#1
D C Marks, P F van der Meer
BACKGROUND: Serum eye drops (SEDs) are used to treat dry eye syndrome and non-healing corneal lesions when other treatments fail. Despite many clinical studies demonstrating the efficacy of both autologous and allogeneic SEDs, there is no internationally harmonized method for producing SEDs. MATERIALS AND METHODS: A 40-question survey requesting information regarding donor selection, blood collection and processing, infectious disease screening, shelf life and regulatory requirements for the production of autologous and allogeneic SEDs was developed by the Biomedical Excellence for Safer Transfusion Collaborative...
March 23, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28321880/group-o-rbcs-where-is-universal-donor-blood-being-used
#2
R L Barty, M Pai, Y Liu, D M Arnold, R J Cook, M P Zeller, N M Heddle
BACKGROUND: There have been recurrent shortages of group O blood due to insufficient inventory and use of group O blood in ABO non-identical recipients. We performed a 12-year retrospective study to determine utilization of group O Rh-positive and Rh-negative red blood cells (RBCs) by recipient ABO group. Reasons for transfusing group O blood to ABO non-identical recipients were also assessed. METHODS: Utilization data from all group O Rh-positive and Rh-negative RBCs transfused at three academic hospitals between April 2002 and March 2014 were included...
March 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28318027/vox-sanguinis-international-forum-on-donor-notification-and-counselling-strategies-for-markers-of-transfusion-transmissible-infections-summary
#3
LETTER
R R Sharma, M Lozano, M Fearon, M Bigham, R Djoudi, P Gallian, G Woimant, C Lee, J N S Leung, W C Tsoi, N Marwaha, S Sachdev, K Tadokoro, Y Tani, H Matsukura, N Shantseva, E Zhiburt, S Hindawi, J Chay, T Huang, D Teo, N Moleli, S Oyonarte, S B A Jayasekara, A Bokhorst, P van den Burg, P Hewitt, C Bianco, D Kessler
No abstract text is available yet for this article.
March 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28318012/vox-sanguinis-international-forum-on-donor-notification-and-counselling-strategies-for-markers-of-transfusion-transmissible-infections
#4
LETTER
R R Sharma, M Lozano, M Fearon, M Bigham, R Djoudi, P Gallian, G Woimant, C Lee, J N S Leung, W C Tsoi, N Marwaha, S Sachdev, K Tadokoro, Y Tani, H Matsukura, N Shantseva, E Zhiburt, S Hindawi, J Chay, T Huang, D Teo, N Moleli, S Oyonarte, S B A Jayasekara, A Bokhorst, P van den Burg, P Hewitt, C Bianco, D Kessler
No abstract text is available yet for this article.
March 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28299792/life-experience-of-the-adult-and-ageing-patient-with-haemophilia-practical-aspects-for-psychological-support
#5
REVIEW
A Torres-Ortuño, R Cid-Sabatel, J Barbero, M García-Dasí
This article discusses, from a psychological perspective, the life experience of the adult and ageing person with haemophilia, including psychological issues, aspects of his personal and social integration, decision-making, communication and other factors that may affect treatment adherence and quality of life. The aim was to provide haematologists and healthcare staff with knowledge and resources to improve communication and support for adult persons with haemophilia, and raise awareness on psychosocial issues related to quality of life, sexuality and aspects associated with ageing with haemophilia...
March 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28271523/safety-and-collection-efficiency-with-a-lower-transfusion-threshold-for-extracorporeal-photopheresis-in-adult-patients-with-graft-versus-host-disease
#6
C Liu, E Schindler, M LeRoy, K Martin-Bredahl, M Dino, K Shah, M Dynis, C S Eby, B J Grossman
BACKGROUND: Extracorporeal photopheresis (ECP) is an established treatment for graft-versus-host disease (GVHD). Various haematocrit thresholds have been used to trigger red blood cells transfusion prior to ECP. Moderate-to-severe GVHD is frequently complicated by anaemia; the safety and collection efficiency with a lower haematocrit for ECP is unknown. METHODS: We prospectively enrolled 26 consecutive adult GVHD patients with haematocrits between 25% and 28·9% who received ECP on the CELLEX system...
March 7, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28271517/effect-of-storage-time-of-platelet-products-on-clinical-outcomes-after-transfusion-a-systematic-review-and-meta-analyses
#7
REVIEW
A L Kreuger, C Caram-Deelder, J Jacobse, J-L Kerkhoffs, J G van der Bom, R A Middelburg
BACKGROUND: Prolonged storage improves availability of platelet products but could also influence safety and efficacy. This systematic review and meta-analyses summarize and quantify the evidence of the effect of storage time of transfused platelets on clinical outcomes. METHODS: A systematic search in seven databases was performed up to February 2016. All studies reporting storage time of platelet products and clinical outcomes were included. To quantify heterogeneity, I² was calculated, and to assess publication bias, funnel plots were constructed...
March 7, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28261815/the-practice-of-platelet-transfusion-prior-to-central-venous-catheterization-in-presence-of-coagulopathy-a-national-survey-among-clinicians
#8
E K van de Weerdt, A L Peters, E J Goudswaard, J M Binnekade, K P van Lienden, B J Biemond, A P J Vlaar
BACKGROUND: Correction of coagulopathy prior to central venous catheter (CVC) placement is advocated by guidelines, while retrospective studies support restrictive use of transfusion products. STUDY DESIGN AND METHODS: We conducted a mixed vignette and questionnaire web survey to investigate current practice and preferences for CVC placement. Clinical vignettes were used to quantify the tendency to administer platelet concentrate. A positive ß-coefficient is in favour of administering platelet concentrate...
March 5, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28220519/red-blood-cell-concentrates-treated-with-the-amustaline-s-303-pathogen-reduction-system-and-stored-for-35-days-retain-post-transfusion-viability-results-of-a-two-centre-study
#9
J A Cancelas, J L Gottschall, N Rugg, S Graminske, M A Schott, A North, N Huang, N Mufti, A Erickson, S Rico, L Corash
BACKGROUND AND OBJECTIVES: Pathogen reduction technology using amustaline (S-303) was developed to reduce the risk of transfusion-transmitted infection and adverse effects of residual leucocytes. In this study, the viability of red blood cells (RBCs) prepared with a second-generation process and stored for 35 days was evaluated in two different blood centres. MATERIALS AND METHODS: In a single-blind, randomized, controlled, two-period crossover study (n = 42 healthy subjects), amustaline-treated (Test) or Control RBCs were prepared in random sequence and stored for 35 days...
February 21, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28220510/diverse-and-novel-rhd-variants-in-australian-blood-donors-with-a-weak-d-phenotype-implication-for-transfusion-management
#10
E C McGowan, G H Lopez, C M Knauth, Y-W Liew, J A Condon, L Ramadi, K Parsons, E M Turner, R L Flower, C A Hyland
BACKGROUND AND OBJECTIVES: Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype against D-epitope profile. MATERIALS AND METHODS: Following automated and manual serology, blood samples from donors reported as 'weak D' (n = 100) were RHD genotyped by a commercial SNP-typing platform and Sanger sequencing...
February 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28220499/three-year-follow-up-of-implementation-of-evidence-based-transfusion-practice-in-a-tertiary-hospital
#11
A Norgaard, J Stensballe, T H de Lichtenberg, J O White, A Perner, M Wanscher, J Hillingsø, M L Holm, M Mau-Sørensen, H Sillesen, L Kjeldsen, C Bäck, J Nielsen, J Seeberg, M B Hansen, P I Johansson
BACKGROUND AND OBJECTIVES: Traditionally, Denmark has had a high rate of allogeneic red blood cell transfusion caused by a liberal transfusion practice despite the existence of restrictive guidelines. We established a Patient Blood Management programme in a tertiary hospital and report the results of the implementation of evidence-based transfusion practice. MATERIALS AND METHODS: Red blood cell transfusion quality indicators were compared with the evidence-based guideline at hospital and department level...
February 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28220496/the-donor-of-the-future-project-first-results-and-further-research-domains
#12
L M Sundermann, W L de Kort, S Boenigk
BACKGROUND: The Alliance of Blood Operators initiated a project labelled 'Donor of the Future'. This study gives an overview of the project results, in particular with regard to country differences. STUDY DESIGN AND METHODS: A large survey (N = 7663) among blood donors in six countries was conducted to analyse the effects of five global areas of change: (1) demographic change; (2) technological developments; (3) health innovations; (4) public, behavioural and attitudinal aspects; and (5) political, economic and environmental issues...
February 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28220494/mortality-outcomes-in-patients-transfused-with-fresher-versus-older-red-blood-cells-a-meta-analysis
#13
C Chai-Adisaksopha, P E Alexander, G Guyatt, M A Crowther, N M Heddle, P J Devereaux, M Ellis, D Roxby, D I Sessler, J W Eikelboom
BACKGROUND: Among transfused patients, the effect of the duration of red blood cell storage on mortality remains unclear. This study aims to compare the mortality of patients who were transfused with fresher versus older red blood cells. METHODS: We performed an updated systematic search in the CENTRAL, MEDLINE, EMBASE and CINAHL databases, from January 2015 to October 2016. RCTs of hospitalized patients of any age comparing transfusion of fresher versus older red blood cells were eligible...
February 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28198084/single-dose-intravenous-iron-infusion-or-oral-iron-for-treatment-of-fatigue-after-postpartum-haemorrhage-a%C3%A2-randomized-controlled-trial
#14
C Holm, L L Thomsen, A Norgaard, J Langhoff-Roos
BACKGROUND AND OBJECTIVES: To evaluate the clinical efficacy of a single-dose intravenous infusion of iron isomaltoside compared with current treatment practice with oral iron measured by physical fatigue in women after postpartum haemorrhage. MATERIALS AND METHODS: Single-centre, open-label, randomized controlled trial. Participants received intravenous iron (n = 97) or oral iron (n = 99), and completed the Multidimensional Fatigue Inventory and Edinburgh Postnatal Depression Scale, and haematological and iron parameters were measured...
February 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28198026/quantitative-assessment-of-haemolysis-secondary-to-modern-infusion-pumps
#15
T G Poder, J-C Boileau, R Lafrenière, L Thibault, N Carrier, M-J de Grandmont, P Beauregard
BACKGROUND: Although most studies have shown that little haemolysis is induced by infusion pumps, there are some notable exceptions. Only limited data are available on the actual infusion pumps that are most used in hospitals in Quebec and elsewhere, namely, the Infusomat(®) Space (peristaltic), Plum A+™ (piston) and Colleague(®) CXE (shuttle) pumps. METHODS: Haemolysis and potassium levels were compared before and after the use of the three different infusion pumps...
February 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28198025/haemoglobin-responses-to-transfusion-in-severe-iron-deficiency-anaemia-potential-impact-of-gastrointestinal-disorders
#16
X Bosch, E Montori, M Guerra-García, J Costa-Rodríguez, M H Quintanilla, P E Tolosa-Chapasian, P Moreno, N Guasch, A López-Soto
BACKGROUND AND OBJECTIVES: Red blood cell (RBC) transfusion may be justified in iron deficiency anaemia (IDA) when an increase in oxygen delivery is needed, as sometimes occurs in subjects with haemoglobin <8·0 mg/dL, serious comorbidities or at risk of cardiovascular instability. Earlier investigations showed that some patients with severe IDA requiring transfusion had lower than expected post-transfusion haemoglobin levels with poorer clinical outcomes than other patients. After hypothesizing that haemoglobin responses to transfusion were different and that the underlying gastrointestinal (GI) disorders causing IDA could be a confounder explaining this association, these responses were analysed in a prospective cohort of IDA adults referred for outpatient GI investigation...
February 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28198023/patient-outcomes-and-amotosalen-uva-treated-platelet-utilization-in-massively-transfused-patients
#17
W Nussbaumer, M Amato, H Schennach, M Astl, C Y Chen, J-S Lin, L Corash, R J Benjamin
BACKGROUND: Amotosalen/UVA-treated platelet concentrates (PCs) have demonstrated efficacy for treating and preventing bleeding in clinical trials and in routine use; however, most studies were performed in haematology/oncology patients. We investigated efficacy during massive transfusion (MT) in general hospitalized patients. METHODS: Universal amotosalen/UVA treatment (INTERCEPT Blood System) of platelets was introduced at a large Austrian medical centre. We performed a retrospective cohort analysis comparing component use, in-hospital mortality and length of stay after MT that included platelet transfusion, for two periods (21 months each) before and after implementation...
February 15, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28181262/descriptive-characteristics-and-in-hospital-mortality-of-critically-bleeding-patients-requiring-massive-transfusion-results-from-the-australian-and-new-zealand-massive-transfusion-registry
#18
R Ruseckaite, Z K McQuilten, J C Oldroyd, T H Richter, P A Cameron, J P Isbister, E M Wood
BACKGROUND AND OBJECTIVES: Critically bleeding patients requiring massive transfusion (MT) are clinically challenging, and limited data exist to support management decisions. This study describes patient characteristics, transfusion support and clinical outcomes from the Australian and New Zealand (NZ) Massive Transfusion Registry (ANZ-MTR). MATERIALS AND METHODS: Retrospective, cohort study of all adult patients receiving MT (≥5 units red blood cells [RBC] in 4 h) at participating ANZ-MTR hospitals, 2011-2015...
February 8, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28176380/factors-influencing-plasma-transfusion-practices-in-paediatric-intensive-care-units-around-the-world
#19
O Karam, P Demaret, A Duhamel, A Shefler, P C Spinella, M Tucci, S Leteurtre, S J Stanworth
BACKGROUND AND OBJECTIVES: Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma to >5% of their patients, whereas another 25% transfused plasma to <1% of their patients. The objective of this study was to explore the factors associated with different plasma transfusion practices in these centres...
February 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28176346/educational-interventions-encouraging-appropriate-use-of-blood-transfusions
#20
A Abelow, A Gafter-Gvili, B Tadmor, M Lahav, D Shepshelovich
BACKGROUND AND OBJECTIVES: The integration of a restrictive packed red blood cells (PRBC) transfusion strategy into daily clinical practice presents a challenge. This study describes the effect of an intervention including educational presentations and computerized alerts on PRBC utilization at a tertiary hospital. MATERIALS AND METHODS: During December 2014, lectures describing recommended PRBC transfusion indications were presented to all non-intensive care departments...
February 2017: Vox Sanguinis
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