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Vox Sanguinis

S Morton, S Stanworth, M Lozano, S J Harrison, F S Hong, P Dennington, Z McQuilten, N Worel, V Compernolle, J M Kutner, A P H Yokoyama, S Nahirniak, M Germain, H Hume, N Robitaille, A Wilson, A Tinmouth, E Massey, C Boulat, G Woimant, P Tiberghien, T J Schulze, J Bux, L Pierelli, C Ballester, T Netelenbos, K A West, C Conry-Cantilena, A Eder, N R Haley, M Yazer, D Triulzi
No abstract text is available yet for this article.
September 14, 2017: Vox Sanguinis
S Morton, S Stanworth, M Lozano, S J Harrison, F S Hong, P Dennington, Z McQuilten, N Worel, V Compernolle, J M Kutner, A P H Yokoyama, S Nahirniak, M Germain, H Hume, N Robitaille, A Wilson, A Tinmouth, E Massey, C Boulat, G Woimant, P Tiberghien, T J Schulze, J Bux, L Pierelli, C Ballester, T Netelenbos, K A West, C Conry-Cantilena, A Eder, N R Haley, M Yazer, D Triulzi
No abstract text is available yet for this article.
September 14, 2017: Vox Sanguinis
G Ramsey
BACKGROUND AND OBJECTIVES: Planning transfusion needs in mass casualty events (MCE) is critical for disaster preparedness. Published data on blood component usage were analysed to seek correlative factors and usage rates. MATERIALS AND METHODS: English-language medical publications since 1980 were searched for MCEs with numbers of patient admissions and transfused RBCs. Reports were excluded from natural disasters or with total RBC use <50 units. Statistical analysis employed Mann-Whitney U-tests and Spearman's rank correlations...
September 10, 2017: Vox Sanguinis
P Klonizakis, G Gioula, M Exindari, C Apostolou, A Kotsiafti, E Vlachaki
Hepatitis E is considered an emerging disease that may be a threat in both developing and industrialized countries all over the world. The risk of chronic hepatitis E virus infection is higher among immunocompromised patients. This study aimed to assess the status of hepatitis E infection in patients with transfusion-dependent thalassaemia from a single centre, in Greece. Our results suggest that the prevalence of hepatitis E infection in this group of patients is low.
September 10, 2017: Vox Sanguinis
J W Kang, J H Seo, K W Youn, Y I Seo, K Huh, G R Choi, H K Min, D J Oh, H J Jo, J N Kim
BACKGROUND AND OBJECTIVES: The Korean Red Cross began nucleic acid amplification testing (NAT) for HIV and HCV in February 2005, and added HBV NAT beginning in June 2012. The current NAT system utilizes a multiplex assay for simultaneous detection of HBV DNA, HCV RNA and HIV-1 RNA. For samples that are reactive in the multiplex assay, we do specific tests for each virus. However, there have been cases of non-discriminated reactive (NDR) results which appear to be the result of non-specific reactions or cross-contamination, although some cases are considered to arise from the presence of low levels of HBV DNA due to occult hepatitis B infection...
September 10, 2017: Vox Sanguinis
K Hsu, M-S Kuo, C-C Yao, H-C Cheng, H-J Lin, Y-S Chan, M Lin
BACKGROUND: The band 3 macrocomplex (also known as the ankyrin-associated complex) on the red cell membrane comprises two interacting subcomplexes: a band 3/glycophorin A subcomplex, and a Rh/RhAG subcomplex. Glycophorin B (GPB) is a component of the Rh/RhAG subcomplex that is also structurally associated with glycophorin A (GPA). Expression of glycophorin B-A-B hybrid GP.Mur enhances band 3 expression and is associated with lower levels of Rh-associated glycoprotein (RhAG) and Rh polypeptides...
August 24, 2017: Vox Sanguinis
E-M Merz, B J H Zijlstra, W L A M de Kort
BACKGROUND AND OBJECTIVES: Show behaviour after invitation to donate varies considerably across donors. More insight into this variation is important for blood banks in achieving stable stocks. This study examined individual factors determining intended show behaviour. Most importantly, however, this study is the first study to account for variation in donor behaviour across different collection sites. MATERIALS AND METHODS: We applied a multilevel approach to data from Donor InSight, including 11 889 donors from 257 fixed and mobile collection sites in the Netherlands...
August 18, 2017: Vox Sanguinis
M Bardyn, S Maye, A Lesch, J Delobel, J-D Tissot, F Cortés-Salazar, P Tacchini, N Lion, H H Girault, M Prudent
BACKGROUND AND OBJECTIVES: Red blood cells (RBCs) suffer from lesions during cold storage, depending in part on their ability to counterbalance oxidative stress by activating their antioxidant defence. The aim of this study was to monitor the antioxidant power (AOP) in erythrocyte concentrates (ECs) during cold storage. MATERIALS AND METHODS: Six ECs were prepared in saline-adenine-glucose-mannitol (SAGM) additive solution and followed during 43 days. The AOP was quantified electrochemically using disposable electrode strips and compared with results obtained from a colorimetric assay...
August 18, 2017: Vox Sanguinis
V C Hoad, C R Seed, J J Fryk, R Harley, R L P Flower, B M Hogema, P Kiely, H M Faddy
BACKGROUND AND OBJECTIVES: Hepatitis E virus (HEV) is a known transfusion-transmissible agent. HEV infection has increased in prevalence in many developed nations with RNA detection in donors as high as 1 in 600. A high proportion of HEV infections are asymptomatic and therefore not interdicted by donor exclusion criteria. To manage the HEV transfusion-transmission (TT) risk some developed nations have implemented HEV RNA screening. In Australia, HEV is rarely notified; although locally acquired infections have been reported, and the burden of disease is unknown...
August 18, 2017: Vox Sanguinis
J Cid
BACKGROUND AND OBJECTIVES: Transfusion-associated graft-versus-host disease (TA-GVHD) is a serious complication of blood component transfusion therapy, caused by donor T lymphocytes. γ-Irradiation or pathogen inactivation methods, capable of inactivating proliferating T cells in blood components, should be selected to prevent TA-GVHD. This review summarizes the published evidence to support the use of pathogen-reduced platelets with amotosalen (150 μm) and ultraviolet A light (UVA, 320-400 nm, 3 J/cm(2) ) for preventing TA-GVHD...
August 18, 2017: Vox Sanguinis
Y L Ji, H Luo, J Z Wen, L Haer-Wigman, B Veldhuisen, L Wei, Z Wang, P Ligthart, M Lodén-van Straaten, Y S Fu, C E van der Schoot, G P Luo
BACKGROUND AND OBJECTIVES: Several comprehensive genotyping platforms for determining red blood cell (RBC) antigens have been established and validated for use in the Caucasian and Black populations, but not for the Chinese. The multiplex ligation-dependent probe amplification (MLPA) assay was validated for RHD genotyping in the Chinese. MATERIALS AND METHODS: The blood samples of 200 D+, 200 D- and 62 D variant Chinese donors were collected. RhD antigen was routinely typed by serological method...
August 18, 2017: Vox Sanguinis
M Punzel, A Kozlova, A Quade, A H Schmidt, R Smith
BACKGROUND AND OBJECTIVES: The Spectra Optia(®) continuous mononuclear cell (CMNC apheresis) system has emerged as the preferred device in peripheral blood stem cell collections over the original two-step Spectra Optia(®) mononuclear cell (MNC apheresis) system. Until now, no comparative data were available for non-stimulated MNC collections that are required for immunotherapy. MATERIALS AND METHODS: We compared collection parameters and product composition for Spectra Optia MNC- as well as CMNC-apheresis systems in non-stimulated MNC collections from 35 registry donors intended for donor lymphocyte infusions...
August 14, 2017: Vox Sanguinis
M Baschin, S Selleng, J-P Zeden, A Westphal, T Kohlmann, H W Schroeder, A Greinacher, T Thiele
BACKGROUND: Platelet concentrates (PC) are transfused to improve primary haemostasis before urgent neurosurgery in patients with intracranial haemorrhage (ICH) receiving antiplatelet therapy (APT). It is unresolved, whether PCs increase the risk for major cardio- and cerebrovascular adverse events. We evaluated a standardized transfusion regimen to reverse APT in patients with ICH who required decompressive neurosurgery. METHODS: Analysed were consecutive patients between 2012 and 2014...
August 14, 2017: Vox Sanguinis
P Owusu-Agyemang, A M Zavala, U U Williams, A Van Meter, J Soliz, R Kapoor, A Shah, M Hernandez, V Gottumukkala, J P Cata
BACKGROUND AND OBJECTIVES: Perioperative red blood cell transfusions (PBT) may be associated with worse survival. In this study of adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), we investigated whether there was an association between PBT and survival. MATERIALS AND METHODS: A retrospective study of adults who had undergone CRS-HIPEC for appendiceal carcinomatosis was conducted. Univariate and multivariate analyses were used to identify factors associated with survival...
August 2017: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Vox Sanguinis
P Kiely, C Styles
BACKGROUND AND OBJECTIVE: The significance of anti-HCV immunoblot (IB) indeterminate results can be difficult to determine. We analysed results for blood donors tested on the MP Diagnostics HCV Blot 3.0 IB assay to determine whether indeterminate results representing past exposure to HCV could be distinguished from those due to non-specific reactivity. MATERIALS AND METHODS: Results for all donors tested by IB during the study period (July 2010 to December 2013) were included in this study...
August 2017: Vox Sanguinis
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Vox Sanguinis
J Gorlin, S Kinney, M K Fung, A Tinmouth
For emergent warfarin reversal, four-factor prothrombin complex concentrates (4FPCCs) are recommended by many international guidelines. We surveyed international clinical sites including members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Most sites have emergent warfarin reversal protocols (53% use PCC, 25% use PCC+ plasma and 2% use plasma alone); however, variation between adjusted dosing and fixed dosing was observed.
August 2017: Vox Sanguinis
J-S David, E-J Voiglio, E Cesareo, O Vassal, E Decullier, P-Y Gueugniaud, S Peyrefitte, K Tazarourte
BACKGROUND: This study aimed to evaluate the accuracy of prehospital parameters, including vital signs and resuscitation (fluids, vasopressor), to predict trauma-induced coagulopathy (TIC, fibrinogen <1·5 g/l or PTratio > 1·5 or platelet count <100 × 10(9) /l), and a massive transfusion (MT, ≥10 RBC units within the first 24 h). METHODS: From a trauma registry (2011-2015), in which patients are prospectively included, we retrospectively retrieved the heart rate (HR), systolic blood pressure (SBP), volume of prehospital fluids and administration of noradrenaline...
August 2017: Vox Sanguinis
P Natarajan, M Santhanakrishnan, C A Tormey, J E Hendrickson
Emerging data in animal models and humans suggest that pathogen-associated and damage-associated molecular patterns variably impact RBC alloantibody formation. In this study, we tested the hypothesis that vaccinations may enhance immune responses to transfused RBCs. The Pneumovax23 vaccine decreased the magnitude of anti-KEL alloimmunization in a murine model, whereas the hepB vaccine did not impact the response; RBC transfusion did not alter immune responses to either vaccine. These data highlight the complexities of the intersection of innate and adaptive immunity and suggest that future studies investigating the pathways through which inflammation impacts alloimmunization are warranted...
August 2017: Vox Sanguinis
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