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Kobe Journal of Medical Sciences

Gulshan Fahmi El Bayani, Nurasi Lidya E Marpaung, Dedy Arnold Sastrajaya Simorangkir, Imelda Rosalyn Sianipar, Nurhadi Ibrahim, Neng Tine Kartinah, Indra Gusti Mansur, Jan S Purba, Ermita I Ibrahim Ilyas
Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats. The overtraining of Wistar rats altered the ratio of IL-1β/IL-1ra in the plasma and hippocampus. Moreover, this overtraining impaired spatial memory consolidation...
October 15, 2018: Kobe Journal of Medical Sciences
Harry Nugroho Eko Surniyantoro, Ahmad Hanim Sadewa, Pramudji Hastuti
Ala55Val and 45 basepair (bp) insertion/deletion (I/D) of UCP2 gene polymorphisms cause a decrease in resting energy expenditure, decreasing fatty acid oxidation and influencing mRNA transcription and stability, thereby increasing the risk of obesity. The purpose of this study was to determine the role of Ala55Val and 45 bp I/D polymorphisms of the UCP2 gene as a risk factor for obesity. This study consisted of 200 Indonesian subjects of Javanese ethnicity consisting of 100 obese and 100 non-obese participants...
October 15, 2018: Kobe Journal of Medical Sciences
Natsuko Tahara, Toshiro Shinke, Hiromasa Otake, Ryo Nishio, Akihide Konishi, Ken-Ichi Hirata
We previously reported that the cytochrome P450 (CYP) 2C19 reduced-function polymorphism was associated with decreased responsiveness to clopidogrel and intra-stent thrombus formation, as well as subsequent ischemic events after drug-eluting stent (DES) implantation. However, the relationship between the polymorphism and bleeding events remains unclear. Among 1427 consecutive patients who underwent DES implantation at Kobe University Hospital, 247 patients (341 lesions) were enrolled for this prospective observational study...
September 18, 2018: Kobe Journal of Medical Sciences
Emi Suzuki, Tomokazu Matsuda, Takeshi Kawamoto, Hiroaki Takahashi, Yusuke Mieda, Yuki Matsuura, Tomoko Takai, Ayumi Kanno, Maki Koyanagi-Kimura, Shun-Ichiro Asahara, Hiroshi Inoue, Wataru Ogawa, Yoshiaki Kido
Endoplasmic reticulum (ER) stress leads to peripheral insulin resistance and the progression of pancreatic beta cell failure in type 2 diabetes. Although ER stress plays an important role in the pathogenesis of diabetes, it is indispensable for cellular activity. Therefore, when assessing the pathological significance of ER stress, it is important to monitor and quantify ER stress levels. Here, we have established a novel system to monitor ER stress levels quickly and sensitively, and using this method, we have clarified the effect of differences in glucose concentration and various fatty acids on the ER of pancreatic β cells...
September 11, 2018: Kobe Journal of Medical Sciences
Saki Sato, Yojiro Ojima, Masatoshi Kanda, Tomohiko Kizaki, Noriyuki Ohara
Endometrial stromal sarcoma (ESS) is a rare malignant tumor of the uterus. We report an uncommon case of ESS composed of both low-grade ESS and high-grade ESS arising from an endometrial polyp. On the findings of magnetic resonance imaging and contrast computed tomography, a patient was suspected of having uterine malignant tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Macroscopically, the tumor was a polypoid lesion in the uterine cavity. The tumor was an endometrial polyp with ESS components...
September 11, 2018: Kobe Journal of Medical Sciences
Yui Enomoto, Akira Kimoto, Hiroaki Suzuki, Shin Nishiumi, Masaru Yoshida, Takahide Komori
AIM: This study aimed to explore novel metabolite biomarker candidates for screening oral squamous cell carcinoma (OSCC). PATIENTS & METHODS: We collected plasma samples from 48 patients with OSCC and 29 with an oral disease and conducted a plasma metabolomics analysis of patients with OSCC using gas chromatography mass spectrometry. Then, we used the cross-validation procedure to ensure the accuracy of biomarker candidates. RESULTS: We selected four biomarker candidates against OSCC...
September 11, 2018: Kobe Journal of Medical Sciences
Saeko Tsujimae, Katsuhiko Yoshii, Keiji Yamana, Kazumichi Fujioka, Kazumoto Iijima, Ichiro Morioka
BACKGROUND: Hyperbilirubinemia in term newborns needing phototherapy within 48 hours after birth, early-onset hyperbilirubinemia, has not been evaluated in recent Japanese healthy birth centers. In this study, we sought to determine the cause of early-onset hyperbilirubinemia in a Japanese healthy birth center and to evaluate the 1992 Kobe University phototherapy treatment criterion requiring total serum bilirubin (TSB) and unbound bilirubin (UB). METHODS: In this retrospective observational study, we collected data on newborns diagnosed with early-onset hyperbilirubinemia between 2009 and 2016 at the Chibune General Hospital...
September 11, 2018: Kobe Journal of Medical Sciences
Mari Kitao, Noriko Setou, Akio Yamamoto, Satoshi Takada
PURPOSE: This study aimed (1) to examine the current status of psychological distress experienced by neonatal intensive care unit (NICU) nurses in supporting bereaved families, (2) to identify the factors associated with psychological distress, and (3) to understand the professional characteristics of nurses experiencing high psychological distress by comparing the study results with those of pediatricians. METHODS: We sent questionnaires to 64 NICUs. The psychological distress of nurses was classified into two groups based on the frequency of psychological distress experienced and analyzed using the χ2 test and Fisher's exact test...
June 6, 2018: Kobe Journal of Medical Sciences
Bambang Udji Djoko Rianto, Didit Yudhanto, Camelia Herdini
Gasoline contains toxic substances such as benzene, toluene, ethylbenzene, xylene (BTEX) that negatively influence gas/fuel station workers' health via continuous inhalation, causing loss of cilia and epithelial cell necrosis of the nasal mucosa. The aim of this study is to determine the correlation between length of work with nasal mucociliary transport time (NMCTT) of the gas/fuel station workers This study used a cross sectional design. The data were obtained from anamnesis, physical and NMCTT examinations of gas station workers in Yogyakarta, during November 2013...
May 28, 2018: Kobe Journal of Medical Sciences
Hitomi Imafuku, Yoshiya Miyahara, Yasuhiko Ebina, Hideto Yamada
BACKGROUND: Both twin pregnancies with complete hydatidiform mole and coexisting normal fetus (CHMCF) and partial hydatidiform mole can be found in association with a live fetus and a placenta displaying a molar degeneration. Two cases of CHMCF using magnetic resonance imaging (MRI) for a diagnosis are reported. CASE: In the first, CHMCF was suspected at 12 weeks of gestation. At 18 weeks of gestation, the existence of molar placenta and a sac separating from fetus and normal placenta was clearly depicted on MRI...
May 28, 2018: Kobe Journal of Medical Sciences
Nesma Nabil Ibrahim Mohamed, Taro Okada, Taketoshi Kajimoto, Shun-Ichi Nakamura
Sphingosine 1-phosphate (S1P) is a bioactive phosphorylated product of sphingosine catalyzed by sphingosine kinase (SphK) and implicated in diverse cellular functions including vesicular trafficking. In the present study we have shown the importance of one of the subtypes of SphK, SphK2, in the regulation of cargo content in exosomes released from human myeloid leukemia K562 cells. First, SphK2 has been shown to localize with N-Rh-PE-positive late endosomes in the cells. Next, siRNA-mediated knockdown of Sphk2 but not SphK1 resulted in a reduction of cargo content in purified exosomes...
May 25, 2018: Kobe Journal of Medical Sciences
Naoki Otsuki, Mio Matsui, Miki Takahashi, Ryohei Sasaki, Naomi Kiyota, Makoto Usami, Ken-Ichi Nibu
OBJECTIVE: TALK score has been developed as an index for predicting the possibility of larynx preservation and prognosis of the patients with advanced laryngeal and hypopharyngeal cancers treated by concurrent chemoradiotherapy (CCRT). In this study, we validated the original TALK score in our clinical setting and modified the score for Japanese population. METHODS: The subjects were 21 patients with laryngeal cancer and 50 patients with hypopharyngeal cancer who underwent CCRT at Kobe University Hospital between April 2007 and August 2012...
April 19, 2018: Kobe Journal of Medical Sciences
Toshihiko Ikuta, Kazumichi Fujioka, Yumi Sato, Mariko Ashina, Sachiyo Fukushima, Shohei Ohyama, Saki Okubo, Keiji Yamana, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Kazumoto Iijima, Ichiro Morioka, Hideto Yamada
Congenital complete atrioventricular block (CCAVB) is a condition in which the atria and ventricles beat independently of each other. CCAVB cases require permanent pacemaker implantation until adulthood. Nevertheless, consensus regarding postnatal medical therapy for bradycardia has not been reached. Here we report the case of a newborn with CCAVB, whose intractable bradycardia was successfully treated with transdermal tulobuterol. Tulobuterol is a selective β2-adrenoceptor agonist, widely used safely as bronchodilator in children...
April 19, 2018: Kobe Journal of Medical Sciences
Saki Okubo, Kazumichi Fujioka, Megumi Yamane, Mariko Ashina, Sachiyo Fukushima, Toshihiko Ikuta, Shohei Ohyama, Keiji Yamana, Akiko Kobayashi, Kazumoto Iijima, Ichiro Morioka
We reported a term newborn case of early onset sepsis caused by nontypeable Haemophilus Influenzae (NTHi) with massive bacterial invasion in the placenta. Based on the consistent results of maternal placental pathology and neonatal bacterial culture, we diagnosed this as vertical transmission of NTHi via vaginal delivery. In general, NTHi infections occur in preterm infants, and our term infant case is very unusual. In conclusion, clinicians should consider NTHi as a cause of neonatal sepsis, even in term infants...
April 19, 2018: Kobe Journal of Medical Sciences
Motoko Tachihara, Daisuke Tamura, Tatsunori Kiriu, Shuntaro Tokunaga, Yukihisa Hatakeyama, Haruko Shinke, Tatsuya Nagano, Kyosuke Nakata, Nobuko Hazeki, Hiroshi Kamiryo, Kazuyuki Kobayashi, Yoshihiro Nishimura
OBJECTIVE: Endobronchial ultrasonography and guide sheath (EBUS-GS) technique has high diagnostic yield in lung nodules. Virtual bronchoscopic navigation (VBN) can lead bronchoscope to the target bronchi. The aim of this prospective study was to compare the diagnostic yield of two bronchoscopic procedures: bronchoscopy under EBUS-GS and VBN with or without x-ray fluoroscopy in small peripheral pulmonary lesions (PPLs, ≤30mm) with apparent CT-bronchus sign. METHODS: 31 patients with PPLs which had apparent CT-bronchus sign were randomly assigned to the X-ray or the non-X-ray groups (18 with and 13 without fluoroscopy) between September 1, 2012, and September 30, 2015...
March 27, 2018: Kobe Journal of Medical Sciences
Caessar Pronocitro, Nenny Sri Mulyani, Afif Avicenna Ghufron, Yugata Halimawan Hazazi, Bambang Ardianto, Didik Setyo Heriyanto
Hepatitis B remains a global burden, with estimated 15 to 40 percents of infected individuals eventually suffer from liver cirrhosis, liver failure, and hepatocellular carcinoma. Vaccination aims to form anti-HBs antibody with protective titer to prevent infection. CD4 T cell lymphocytes are known to play a major role in establishing immunity after vaccination. This study aimed to investigate protective titer rate among Indonesian children in Special Region of Yogyakarta following hepatitis B vaccination and correlation between anti-HBs titer and CD4 count...
January 17, 2018: Kobe Journal of Medical Sciences
Yasuyuki Shimizu, Hiroaki Akasaka, Daisuke Miyawaki, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Saki Osuga, Sachiko Inubushi, Ryuichi Yada, Yasuo Ejima, Kenji Yoshida, Takeaki Ishihara, Ryohei Sasaki
In cancer research, small animal models, for example, mice, rats, or rabbits, facilitate the in-depth study of biological processes and the effects of radiation treatment that can lead to breakthrough discoveries. However, the physical quality of small animal irradiation systems has not been previously evaluated. In this study, we evaluate the quality of a small animal irradiation system using GAFCHROMIC™ film and a Tough Water Phantom. The profiles and percentage depth dose curves for several irradiation conditions were measured to evaluate the quality of the irradiation system...
January 17, 2018: Kobe Journal of Medical Sciences
Emma Tabe Eko Niba, Mawaddah Ar Rochmah, Nur Imma Fatimah Harahap, Hiroyuki Awano, Ichiro Morioka, Kazumoto Iijima, Toshio Saito, Kayoko Saito, Atsuko Takeuchi, Poh San Lai, Yoshihiro Bouike, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders. The symptoms are caused by defects of lower motor neurons in the spinal cord. More than 95% of SMA patients are homozygous for survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique using dried blood spot (DBS) on filter paper. This system is convenient for mass screening in the large population and/or first-tier diagnostic method of the patients in the remote areas...
December 18, 2017: Kobe Journal of Medical Sciences
Masaya Akashi, Kenji Matsuo, Manabu Shigeoka, Yasumasa Kakei, Takumi Hasegawa, Akira Tachibana, Shungo Furudoi, Takahide Komori
The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions...
December 18, 2017: Kobe Journal of Medical Sciences
Takako Kanatani, Issei Nagura, Yoshifumi Harada, Masatoshi Sumi
The distribution of electrophysiological severity of carpal tunnel syndrome (CTS) in an outpatient setting and whether electrophysiological severity could be an objective tool for decision-making regarding choice of surgery were investigated. During conservative treatment, 1079 outpatients with idiopathic CTS were classified according to the electrophysiological severity scale (Stage 1-5). The results were provided to the patients and explained, but they were not indicated a treatment protocol intentionally...
December 18, 2017: Kobe Journal of Medical Sciences
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