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Kobe Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29434181/efficacy-of-hepatitis-b-vaccination-among-children-in-special-region-of-yogyakarta-indonesia-evaluation-of-humoral-and-cellular-immunity
#1
Caessar Pronocitro, Nenny Sri Mulyani, Afif Avicenna Ghufron, Yugata Halimawan Hazazi, Bambang Ardianto, Didik Setyo Heriyanto
Hepatitis B remains a global burden, with estimated 15 to 40 percents of infected individuals eventually suffer from liver cirrhosis, liver failure, and hepatocellular carcinoma. Vaccination aims to form anti-HBs antibody with protective titer to prevent infection. CD4 T cell lymphocytes are known to play a major role in establishing immunity after vaccination. This study aimed to investigate protective titer rate among Indonesian children in Special Region of Yogyakarta following hepatitis B vaccination and correlation between anti-HBs titer and CD4 count...
January 17, 2018: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434180/evaluation-of-a-small-animal-irradiation-system-for-animal-experiments-using-ebt3-model-gafchromic%C3%A2-film
#2
Yasuyuki Shimizu, Hiroaki Akasaka, Daisuke Miyawaki, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Saki Osuga, Sachiko Inubushi, Ryuichi Yada, Yasuo Ejima, Kenji Yoshida, Takeaki Ishihara, Ryohei Sasaki
In cancer research, small animal models, for example, mice, rats, or rabbits, facilitate the in-depth study of biological processes and the effects of radiation treatment that can lead to breakthrough discoveries. However, the physical quality of small animal irradiation systems has not been previously evaluated. In this study, we evaluate the quality of a small animal irradiation system using GAFCHROMIC™ film and a Tough Water Phantom. The profiles and percentage depth dose curves for several irradiation conditions were measured to evaluate the quality of the irradiation system...
January 17, 2018: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434179/sma-diagnosis-detection-of-smn1-deletion-with-real-time-mcop-pcr-system-using-fresh-blood-dna
#3
Emma Tabe Eko Niba, Mawaddah Ar Rochmah, Nur Imma Fatimah Harahap, Hiroyuki Awano, Ichiro Morioka, Kazumoto Iijima, Toshio Saito, Kayoko Saito, Atsuko Takeuchi, Poh San Lai, Yoshihiro Bouike, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders. The symptoms are caused by defects of lower motor neurons in the spinal cord. More than 95% of SMA patients are homozygous for survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique using dried blood spot (DBS) on filter paper. This system is convenient for mass screening in the large population and/or first-tier diagnostic method of the patients in the remote areas...
December 18, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434178/a-case-series-of-fibro-osseous-lesions-of-the-jaws
#4
Masaya Akashi, Kenji Matsuo, Manabu Shigeoka, Yasumasa Kakei, Takumi Hasegawa, Akira Tachibana, Shungo Furudoi, Takahide Komori
The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions...
December 18, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434177/the-role-of-electrophysiological-severity-scales-for-decision-making-with-regard-to-surgery-in-idiopathic-carpal-tunnel-syndrome
#5
Takako Kanatani, Issei Nagura, Yoshifumi Harada, Masatoshi Sumi
The distribution of electrophysiological severity of carpal tunnel syndrome (CTS) in an outpatient setting and whether electrophysiological severity could be an objective tool for decision-making regarding choice of surgery were investigated. During conservative treatment, 1079 outpatients with idiopathic CTS were classified according to the electrophysiological severity scale (Stage 1-5). The results were provided to the patients and explained, but they were not indicated a treatment protocol intentionally...
December 18, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434176/associations-between-caga-vaca-and-the-clinical-outcomes-of-helicobacter-pylori-infections-in-okinawa-japan
#6
Tomoko Inagaki, Shin Nishiumi, Yoshiyuki Ito, Akiyo Yamakawa, Yukinao Yamazaki, Masaru Yoshida, Takeshi Azuma
Helicobacter pylori, which is involved in the pathogenesis of gastroduodenal disease, produces CagA and VacA as major virulence factors. CagA is classified into East Asian and Western types based on the number and sequences of its Glu-Pro-Ile-Tyr-Ala motifs. The vacA gene has three polymorphic regions: the signal (s), intermediate (i), and middle (m) regions. The lowest gastric cancer mortality rate is seen in Okinawa. On the Japanese mainland (Honshu), most H. pylori produce s1/m1-VacA, which exhibits strong toxicity, and East Asian-type CagA...
November 22, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434175/can-hybrid-educational-activities-of-team-and-problem-based-learning-program-be-effective-for-japanese-medical-students
#7
Kentaro Iwata, Asako Doi
BACKGROUND: The purpose of this study is to investigate the medical students'perceptions of the Hybrid Educational Activities between team based learning (TBL) and problem based learning (PBL) Program (HEATAPP), a novel educational program that combines characteristics of PBL and TBL. METHODS: A five-day HEATAPP on infectious diseases was provided to 4th year medical students at Kobe University School of Medicine, Kobe, Japan. After the program, a focus group discussion was held among 6 medical students who participated in HEATAPP...
November 10, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434174/macrophages-highly-express-carbonic-anhydrase-2-and-play-a-significant-role-in-demineralization-of-the-ectopic-calcification
#8
Agian Jeffilano Barinda, Koji Ikeda, Ken-Ichi Hirata, Noriaki Emoto
Vascular calcification is an important risk factor for cardiovascular disease, and is closely associated with all-cause mortality. Recently, it has been revealed that vascular calcification is not a passive precipitation of circulating minerals, but is a process actively regulated through machinery similar to bone formation. During the bone remodeling, osteoclasts execute the bone resorption by releasing hydrogen ions to dissolve minerals; however, molecular mechanisms underlying decalcification of ectopically calcified lesions remain largely unknown...
October 16, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434173/gender-effects-on-the-clinical-phenotype-in-japanese-patients-with-spinal-muscular-atrophy
#9
Mawaddah Ar Rochmah, Ai Shima, Nur Imma Fatimah Harahap, Emma Tabe Eko Niba, Naoya Morisada, Shinichiro Yanagisawa, Toshio Saito, Kaori Kaneko, Kayoko Saito, Ichiro Morioka, Kazumoto Iijima, Poh San Lai, Yoshihiro Bouike, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease caused by a mutation in SMN1. SMA is classified into three subtypes (types 1, 2, 3) based on achieved motor milestones. Although NAIP and SMN2 are widely accepted as SMA-modifying factors, gender-related modifying factors or gender effects on the clinical phenotype are still controversial. METHODS: A total of 122 Japanese patients with SMA, of which SMN1 was homozygously deleted, were analyzed from the perspective of the achieved motor milestone, NAIP status and SMN2 copy number...
October 16, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434172/new-improved-version-of-the-mcop-pcr-screening-system-for-detection-of-spinal-muscular-atrophy-gene-smn1-deletion
#10
Masakazu Shinohara, Mawaddah Ar Rochmah, Kenta Nakanishi, Nur Imma Fatimah Harahap, Emma Tabe Eko Niba, Toshio Saito, Kayoko Saito, Atsuko Takeuchi, Yoshihiro Bouike, Hisahide Nishio
BACKGROUND: Spinal muscular atrophy (SMA) is a frequent autosomal recessive disorder, characterized by lower motor neuron loss in the spinal cord. More than 95% of SMA patients show homozygous survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique. However, non-specific amplification products were observed with mCOP-PCR, which might lead to erroneous interpretation of the screening results...
September 7, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434171/association-between-intra-circuit-activated-clotting-time-and-incidence-of-bleeding-complications-during-continuous-renal-replacement-therapy-using-nafamostat-mesilate-a-retrospective-pilot-observational-study
#11
Yuji Miyatake, Shohei Makino, Kenta Kubota, Moritoki Egi, Satoshi Mizobuchi
It has been proposed that anticoagulant activity during continuous renal replacement therapy with nafamostat mesilate can be monitored by using intra-circuit activated clotting time. However, it is still unclear whether activated clotting time would be useful for this purpose. We conducted a retrospective study and included 76 patients who required continuous renal replacement therapy using nafamostat mesilate. We obtained information for pre- and post-filter activated clotting times and bleeding complications...
August 30, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434170/role-of-sirp%C3%AE-in-homeostatic-regulation-of-t-cells-and-fibroblastic-reticular-cells-in-the-spleen
#12
Datu Respatika, Yasuyuki Saito, Ken Washio, Satomi Komori, Takenori Kotani, Hideki Okazawa, Yoji Murata, Takashi Matozaki
Signal regulatory protein α (SIRPα), is an immunoglobulin superfamily protein that is predominantly expressed in macrophages and dendritic cells (DCs), especially CD4+ conventional DCs (cDCs). In this study, we demonstrated that, in addition to the reduced number of CD4+ cDCs, the number of T cells was significantly decreased in the spleen of Sirpa-/- mice, in which full-length of SIRPα protein was systemically ablated. The size of the T cell zone was markedly reduced in the spleen of Sirpa-/- mice. In addition, Sirpa-/- mice revealed a marked reduction of CCL19, CCL21, and IL-7 expression, which are thought to be important for homeostasis of T cells in the spleen...
August 10, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434169/different-patterns-in-abdominal-stab-wound-in-the-self-inflicted-and-assaulted-patients-an-observational-analysis-of-single-center-experience
#13
Takeshi Nishimura, Hiroyuki Sakata, Taihei Yamada, Mariko Terashima, Kunihiro Shirai, Isamu Yamada, Joji Kotani
Patterns of penetrating abdominal stab wounds (ASW) may be different according to the mechanism of injury. The purpose of this study was to review and characterize penetrating abdominal stab wounds in self-inflicted wound patients and assaulted patients. We retrospectively analyzed patients with ASW who were admitted to our emergency department from 2007 to 2015. The patients were divided into two groups: self-inflicted wound group and assaulted group. There were 46 stabbing cases in 45 different patients (25 males, 21 females; average age 47 y, range 21 to 85 y)...
July 20, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434168/compatibility-and-stability-of-nab-paclitaxel-in-combination-with-other-drugs
#14
Naomi Mizuta, Tsutomu Nakagawa, Kazuhiro Yamamoto, Tatsuya Nishioka, Manabu Kume, Hiroo Makimoto, Ikuko Yano, Hironobu Minami, Midori Hirai
Albumin-bound paclitaxel (Abraxane®, nab-paclitaxel) is not recommended to be administered concurrently or sequentially with other drugs due to concern for instability. The need to administer drugs separately increases infusion time. We evaluated the compatibility and stability of solutions containing nab-paclitaxel and other drugs, including gemcitabine hydrochloride, carboplatin, dexamethasone sodium phosphate, granisetron hydrochloride, and palonosetron hydrochloride. We visually examined changes in appearance, pH, and concentration of the mixed solutions of nab-paclitaxel and other drugs for up to 24 h...
July 20, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434167/history-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-and-acute-pancreatitis-as-risk-factors-for-post-ercp-pancreatitis
#15
Eiji Funatsu, Atsuhiro Masuda, Mamoru Takenaka, Takashi Nakagawa, Hideyuki Shiomi, Hayato Yoshinaka, Takashi Kobayashi, Arata Sakai, Yosuke Yagi, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takeshi Azuma
BACKGROUND: Previous pancreatitis is a definite patient-related risk factor for pancreatitis after endoscopic retrograde cholangiopancreatography (post-ERCP pancreatitis: PEP). However, the effects of differences in the history of PEP and acute pancreatitis on the occurrence of PEP have not been fully investigated. We examined the relationship between previous PEP or previous acute pancreatitis and procedural factors associated with PEP. METHODS: Clinical data on 1,334 consecutive patients undergoing ERCP between April 2006 and June 2010 were collected...
May 15, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28490713/phospholipase-d-is-dispensable-for-epidermal-growth-factor-induced-chemotaxis
#16
Chihoko Hirai, Shaymaa Mohamed Mohamed Badawy, Lifang Zhang, Taro Okada, Taketoshi Kajimoto, Shunichi Nakamura
α-Synuclein (α-Syn) is implicated in several neurodegenerative disorders, including Parkinson's disease, known collectively as the synucleinopathies. α-Syn is known to be secreted from the cells and may contribute to the progression of the disease. Although extracellular α-Syn is shown to impair platelet-derived growth factor-induced chemotaxis, molecular mechanism of α-Syn-induced motility failure remains elusive. Here we have aimed at phospholipase D (PLD) as a potential target for α-Syn and examined the involvement of this enzyme in α-Syn action...
May 9, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28490712/application-of-physiologically-based-pharmacokinetic-modeling-for-the-prediction-of-tofacitinib-exposure-in-japanese
#17
RANDOMIZED CONTROLLED TRIAL
Misaki Suzuki, Susanna Tse, Midori Hirai, Yoichi Kurebayashi
Tofacitinib (3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3 -oxopropanenitrile) is an oral Janus kinase inhibitor that is approved in countries including Japan and the United States for the treatment of rheumatoid arthritis, and is being developed across the globe for the treatment of inflammatory diseases. In the present study, a physiologically-based pharmacokinetic model was applied to compare the pharmacokinetics of tofacitinib in Japanese and Caucasians to assess the potential impact of ethnicity on the dosing regimen in the two populations...
May 9, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28490711/purification-crystallization-and-x-ray-diffraction-study-of-the-c-terminal-domain-of-human-herpesvirus-6a-immediate-early-protein-2
#18
Junjie Wang, Mitsuhiro Nishimura, Aika Wakata, Yasuko Mori
Human herpesvirus 6A (HHV-6A) starts its replication cycle following the action of immediate early proteins that transactivate viral promoters. Immediate early protein 2 (IE2) of HHV-6A is a 1500 amino acid polypeptide with a C-terminal region that is conserved among beta-herpesvirus subfamily members. In this study, a structural domain in the homologous C-terminal region was subjected to secondary structure prediction, and residues 1324-1500 were subsequently designated as the C-terminal domain of IE2 (IE2-CTD)...
April 7, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28289271/increased-pittsburgh-compound-b-accumulation-in-the-subcortical-white-matter-of-alzheimer-s-disease-brain
#19
Yuichi Wakabayashi, Kazunari Ishii, Chisa Hosokawa, Tomoko Hyodo, Hayato Kaida, Minoru Yamada, Yukinobu Yagyu, Masakatsu Tsurusaki, Takenori Kozuka, Kazuro Sugimura, Takamichi Murakami
Using 11C-Pittsburgh compound B (PiB)-PET and MRI volume data, we investigated whether white matter (WM) PiB uptake in Alzheimer's disease (AD) brain is larger than that of cortical PiB uptake-negative (PiB-negative) brain. Forty-five subjects who underwent both PiB-PET and MRI were included in the study (32 AD patients with cortical PiB-positive and 13 cortical amyloid -negative patients). Individual areas of gray matter (GM) and WM were segmented, then regional GM and WM standard uptake value ratio (SUVR) normalized to cerebellar GM with partial volume effects correction was calculated...
March 13, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28289270/changes-in-heart-rate-and-autonomic-nervous-activity-after-orthopedic-surgery-in-elderly-japanese-patients
#20
Chieko Tan, Nao Saito, Ikuko Miyawaki
Evidence regarding nursing support for delirium prevention is currently insufficient. An evaluation of changes in autonomic nervous activity over time after surgery would elucidate the features of autonomic nervous activity in patients with delirium. These results could provide a basis for effective nursing intervention and timing for preventing the onset of delirium. Here, we aimed to obtain basic data on effective nursing interventions for preventing the onset of postoperative delirium. Heart rate variability was recorded during the morning and nighttime on the day before surgery until 3 days postoperatively in elderly patients who underwent orthopedic surgery to investigate the manner in which heart rate and autonomic nervous activity changed over time...
February 15, 2017: Kobe Journal of Medical Sciences
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