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Nagoya Journal of Medical Science

Tomoaki Tamada, Rei Enatsu, Noriaki Kikuchi, Nobuhiro Mikuni
Meningiomas rarely exhibit cystic lesions with mural nodules, and may be misdiagnosed as intraparenchymal cystic tumors. We herein present a 64-year-old woman with a cystic lesion and enhancing mural nodule in the left temporal lobe accompanied by peritumoral brain edema. Differential diagnoses included low-grade gliomas, hemangioblastoma, and cystic meningioma. Gross total resection of the tumor was achieved through a temporal surgical approach. Intraoperative findings showed that the tumor was an extraparenchymal tumor...
August 2018: Nagoya Journal of Medical Science
Daisuke Kurita, Yasuji Mokuno, Hideo Matsubara, Hirokazu Kaneko, Mikihiro Shamoto, Akira Satou, Shinsuke Iyomasa
Hepatic carcinosarcoma (HCS) generally presents in advanced stages, demonstrates aggressive behavior, and has a poor prognosis. Other than curative primary resection, no effective treatment options exist. We present a case of resected HCS with four repeat resections for solitary lymph node recurrence followed by chemoradiotherapy with doxorubicin and ifosfamide. A 67-year-old Japanese man was admitted to our hospital for evaluation of an asymptomatic hepatic tumor. The patient underwent right hepatectomy with a presumptive preoperative diagnosis of atypical hepatocellular carcinoma...
August 2018: Nagoya Journal of Medical Science
Kazuyoshi Kobayashi, Kei Ando, Yusuke Suzuki, Yuko Inagaki, Yoshimasa Nagao, Naoki Ishiguro, Shiro Imagama
A fall may cause trauma and bone fracture, which can affect ADL and QOL. Therefore, countermeasures to prevent falls are important. There are many reports on falls in hospitalized patients, but few for outpatients. Therefore, the purpose of this study is to report the characteristics of outpatient falls that occurred in hospital over five years to identify factors associated with fall in these patients. From April 2012 to March 2017, we investigated fall cases in outpatients using a hospital database. Fall that led to fracture or a life-threatening injury was defined as an adverse event...
August 2018: Nagoya Journal of Medical Science
Hideo Saka, Akiko Kada
Argon-plasma coagulation, high-frequency electrosurgical snare, laser therapy, and microwave treatment are therapeutic options to reduce tumor-related stenosis of the central airway. These treatments may cause airway fire under a high concentration of oxygen, so FiO2 levels must be ≤40%. This restriction may be dangerous when treating patients with respiratory failure. The cryosurgery unit, ERBE-CRYO2, facilitates treatment under an FiO2 level of 100%, safely reducing this risk. In Japan, CRYO2 has been approved for cryobiopsy and foreign body removal, but not for tissue removal at the site of obstruction or stenosis due to lack of sufficient evidence...
August 2018: Nagoya Journal of Medical Science
Daisuke Shimizu, Norihiro Yuasa, Hideo Miyake, Eiji Takeuchi, Kanji Miyata, Shigeki Itoh
The standardized uptake value (SUV) is a marker of tumor glucose metabolism, detected using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and may reflect tumor aggressiveness. The purpose of this study was to evaluate the clinical significance of maximum SUV (SUVmax) of primary esophageal cancer (EC) lesions. A total of 86 patients with EC who underwent pre-treatment FDG-PET and R0-resection were included in our study. The mean patient age was 65 years, and 87% were men. Histologically, cancers included squamous cell carcinomas, adenocarcinomas, and other tumors in 72, 3, and 11 patients, respectively...
August 2018: Nagoya Journal of Medical Science
Kouji Aimiya, Takayoshi Mamiya, Katsunori Tabuchi, Toshiyuki Kita, Masayuki Hiramatsu
Meropenem (MEPM) is a broad-spectrum antibiotic prescribed to patients with moderate or severe pneumonia. It is well recognized that appropriate medicine reduces the burden on not only young patients but elderly ones as well. We enrolled 56 patients aged 75 and over who were diagnosed with moderate or severe pneumonia (body temperature: ≧37.5 °C; white blood cell (WBC) count: ≧10,000/μL; C-reactive protein (CRP): ≧4 mg/dL) on the basis of Clinical Evaluation Methods for New Antimicrobial Agents to Treat Respiratory Infections defined by the Japanese Society of Chemotherapy, at the National Hospital Organization Kanazawa Medical Center from January 1, 2007 to May 31, 2010...
August 2018: Nagoya Journal of Medical Science
Nyi Nyi Latt, Yu Mon Saw, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima
In Myanmar, the Control of Smoking and Consumption of Tobacco Products Law (Tobacco Control Law; TCL), which covers the prohibition of sale of tobacco to minors and all forms of tobacco advertisement, was enacted in 2006. This study aimed to examine the awareness of the TCL among high school students. A cross-sectional study was conducted in November 2015. Participants were 1,339 high school students (554 boys and 785 girls) from two regions and two states of Myanmar. Data were collected using anonymous self-administered questionnaires and revealed that 78...
August 2018: Nagoya Journal of Medical Science
Jiro Takeuchi, Yu Sakagami
Increasing numbers of international students require Japanese universities to provide mental health support as one of their primary responsibilities. The problem with the provision of such support is that the stigma of mental disorder causes many individuals to avoid seeking help. We aim to clarify the association between stigma and mental illness to develop anti-stigma education. We performed a cross-sectional observational study. The target population comprised international students enrolled in a Japanese university...
August 2018: Nagoya Journal of Medical Science
Tsuyoshi Morishita, Kazuhiro Toriyama, Keisuke Takanari, Shunjiro Yagi, Katsumi Ebisawa, Masashi Hishida, Yuji Narita, Satoshi Osaga, Yoshihiro Nishida, Yuzuru Kamei
Some patients undergo postoperative chemotherapy despite showing impaired wound healing after a major surgery. We speculated that postoperative chemotherapy further delays wound healing in these patients. This study aimed to compare the effects of doxorubicin (DXR) in ischemic skin flap and normal incisional wound models after surgery. A 2-cm incisional wound was made in group 1 rats, and saline was injected intravenously, following surgery on the same day. Incisional wound was made in group 2-5 rats, and 8 mg/kg DXR was injected intravenously, following surgery on the same day and after 7, 14, and 21 days respectively...
August 2018: Nagoya Journal of Medical Science
Mitsuro Kanda, Chie Tanaka, Kenta Murotani, Daisuke Kobayashi, Seiji Ito, Yoshinari Mochizuki, Kiyoshi Ishigure, Akiharu Ishiyama, Hitoshi Teramoto, Toshifumi Murai, Takahiro Asada, Hidenobu Matsushita, Michitaka Fujiwara, Yasuhiro Kodera
Anastomotic leakage is a major cause of prolonged hospitalization after gastrectomy and sometimes leads to fatal complications, such as abdominal abscess and sepsis. Arginine, glutamine, and β-hydroxy-β-methylbutyrate (HMB) are indispensable for biosynthesis of collagen, which plays an important role in the process of wound healing. However, treatment effects of amino acid supplements containing HMB on the healing process of anastomotic leakage after gastrectomy remain unclear. We designed an open-label, multicenter, phase II clinical trial to evaluate the therapeutic efficacy of an enteral amino acid supplement consisting of arginine, glutamine, and HMB (Abound, Abbott Japan Co...
August 2018: Nagoya Journal of Medical Science
Kazuyoshi Kobayashi, Kei Ando, Yuko Inagaki, Yusuke Suzuki, Yoshimasa Nagao, Naoki Ishiguro, Shiro Imagama
Falls are common in elderly patients and comprise 20-30% of all incident reports in hospitals. The current study examined falls in orthopedic patients among 212,617 inpatients admitted to our hospital from April 2012 to March 2017, using a prospective database in the hospital event reporting system. The risk of fall was evaluated using a fall assessment scoresheet at admission and during hospitalization, based on which patients were divided into risk grades 1, 2 and 3. Fall leading to fracture or a life-threatening injury was defined as an adverse event...
August 2018: Nagoya Journal of Medical Science
Bakhtar Rasekh, Yu Mon Saw, Sayed Azimi, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima
Despite the increase in the number of drug treatment centers, patients with drug addicts have been increasing without the improvement of treatment in Afghanistan. This study aimed to examine the associations of the completion of drug addiction treatment with motivational interviewing (MI) and other factors among male drug users in Afghanistan. Subjects were patients admitted to Jangalak Hospital in Kabul, Afghanistan in 2014 and 2015. Systematic sampling and supplementary sampling were applied. The records of 327 males aged 18 to 54 years were collected from those of 3,373 male inpatients...
August 2018: Nagoya Journal of Medical Science
Tomohiro Kogata, Tetsuya Iidaka
Several studies have investigated perceptual processes in patients with schizophrenia. Research confirms that visual impairments are one of the most important features of schizophrenia. Many studies, using behavioral and psychological experiments, confirm that visual impairments can be used to determine illness severity, state, and best treatments. Herein, we review recent research pertaining to visual function in patients with schizophrenia and highlight the relationship between laboratory findings and subjective, real-life reports from patients themselves...
August 2018: Nagoya Journal of Medical Science
Shuji Iritani, Chikako Habuchi, Hirotaka Sekiguchi, Youta Torii
The Japan Agency of Medical Research and Development (AMED) has approved the budget for the 5-year project called Establishment of the JAPAN Brain Bank Network, which commenced in 2016. This project was established with the aim of storing brain tissue samples to enable research on the etiologies and mechanisms of psychiatric diseases, which would eventually improve standards of clinical treatment for these diseases. Japanese researchers in the field of biological psychiatry have historically depended on Western brain banks, particularly from Europe and the United States, which is regrettable...
August 2018: Nagoya Journal of Medical Science
Yuko Tashima, Tetsuya Okajima
The Notch signaling pathway is highly conserved and essential for animal development. It is required for cell differentiation, survival, and proliferation. Regulation of Notch signaling is a crucial process for human health. Ligands initiate a signal cascade by binding to Notch receptors expressed on a neighboring cell. Notch receptors interact with ligands through their epidermal growth factor-like repeats (EGF repeats). Most EGF repeats are modified by O -glycosylation with residues such as O -linked N -acetylglucosamine ( O -GlcNAc), O -fucose, and O -glucose...
August 2018: Nagoya Journal of Medical Science
Masahisa Katsuno, Kentaro Sahashi, Yohei Iguchi, Atsushi Hashizume
Neurodegenerative diseases are disorders that are characterized by a progressive decline of the motor and/or cognitive function caused by a selective loss of neurons within the central nervous system. Recent advancements in the translational research have facilitated extensive insights into the molecular pathophysiology of neurodegenerative diseases. Nonetheless, a myriad of compounds that suppressed the disease progression in cellular and animal models did not exhibit efficacy in clinical trials. Perhaps, various biological, medical, and methodological factors could be attributed to unfavorable results of clinical trials of such disease-modifying therapies...
August 2018: Nagoya Journal of Medical Science
Yoshiaki Tsukizawa, Keisuke Kondo, Toshihisa Ichiba, Hiroshi Naito, Kazuhito Mizuki, Ken Masuda
Nivolumab, a new immune checkpoint inhibitor that has been found to improve outcomes for patients with some advanced cancers, is being increasingly used. Immune checkpoint inhibitors can cause immune-related adverse events, including dermatitis, enterocolitis, hepatitis and hypophysitis, but adrenal insufficiency rarely occurs. We present a case of Nivolumab-induced adrenal insufficiency in a man who complained of refractory hypotension. A 52-year-old man with non-small cell lung cancer visited our emergency department complaining of fatigue and diarrhea...
May 2018: Nagoya Journal of Medical Science
Kazunori Shintai, Noriaki Matsubara, Takashi Izumi
The authors present a 60-year-old man with a partially thrombosed, intracranial vertebral artery aneurysm. A vascular channel in intra-aneurysmal thrombus was effectively identified with high-resolution cone beam CT (DynaCT Micro: Siemens Medical Solutions, Erlangen, Germany). Pre-procedural vertebral angiogram implied a perforating artery arising from near neck of the aneurysm and DynaCT Micro performed before approaching to the lesion demonstrated a vascular channel running in intra-aneurysmal thrombus which could not be distinguished from perforators with other imaging modalities...
May 2018: Nagoya Journal of Medical Science
Tomoko Kobayashi, Michihiro Kono, Mutsumi Suganuma, Hirotaka Akita, Ayaka Takai, Kiyohiro Tsutsui, Yu Inasaka, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama
Dyschromatosis symmetrica hereditaria (DSH) is one of the genetic pigmentation disorders and shows characteristic mixture of hyper- and hypo-pigmented small macules on the extremities. Heterozygous mutations in the adenosine deaminase acting on RNA1 gene ( ADAR1 ) cause DSH. In the present study, we report five cases of DSH and identify a distinct known mutation in each patient. Furthermore, we review previously described cases with the five ADAR1 mutations found in the present study. We reviewed clinical and molecular findings in the present and previously reported cases and found an identical mutation can result in various phenotypic severities, even in one family...
May 2018: Nagoya Journal of Medical Science
Rinzaburo Matsuura, Osamu Watanabe, Masanao Nakamura, Takeshi Yamamura, Masanobu Matsushita, Hiroki Suhara, Kazuhiro Furukawa, Takuya Ishikawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto
Fecal calprotectin (FC) has drawn attention as a biomarker in the evaluation of Crohn's disease (CD). However, few reports have provided a detailed examination of the relationship between small-bowel CD lesions and FC levels. The present study aimed to examine the entire small bowel using double-balloon endoscopy (DBE) and to determine the relationship between the endoscopic activity in small-bowel CD and FC levels. Twenty small-bowel CD patients, who underwent DBE, were prospectively enrolled. Endoscopic evaluation was based on the simple endoscopic score for CD, with the small bowel divided into four regions...
May 2018: Nagoya Journal of Medical Science
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