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Nagoya Journal of Medical Science

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https://www.readbyqxmd.com/read/28008208/ruptured-partially-thrombosed-anterior-inferior-cerebellar-artery-aneurysms-two-case-reports-and-review-of-literature
#1
Fumiaki Kanamori, Teppei Kawabata, Shinsuke Muraoka, Takao Kojima, Tadashi Watanabe, Norikazu Hatano, Yukio Seki
Aneurysms arising from the distal anterior inferior cerebellar artery (AICA) are very rare. When the parent artery is an AICA-posterior inferior cerebellar artery (PICA) variant, occlusion of the artery, even distal to the meatal loop, leads to a significant area of cerebellar infarction. We report two cases of ruptured partially thrombosed distal AICA aneurysms. In both cases, the parent artery was an AICA-PICA variant. The aneurysms were clipped in one case and trapped following occipital artery (OA)-AICA anastomosis in another case...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008207/what-do-we-know-about-pulmonary-blastoma-review-of-literature-and-clinical-case-report
#2
Dorota Brodowska-Kania, Ewa Kotwica, Aleksandra Paturej, Witold Sośnicki, Janusz Patera, Agnieszka Giżewska, Stanisław Niemczyk
Pulmonary blastoma (PB) is a rare form of lung tumour and is accountable for 0.25-0.5% of primary pulmonary malignancies. Initially pulmonary blastoma was divided into three subtypes: biphasic pulmonary blastoma (BPB) consisting of an epithelial and mesenchymal component, well differentiated fetal adenocarcinoma (WDFA) built of well differentiated epithelium and a mesenchymal component and malignant pleuropulmonary blastoma (PPB). Prognosis in this type of cancer is really poor. We present a current review of literature and a clinical case report...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008206/aggressive-resection-of-frequent-peritoneal-recurrences-in-colorectal-cancer-contributes-to-long-term-survival
#3
Koji Komori, Takashi Kinoshita, Oshiro Taihei, Seiji Ito, Tetsuya Abe, Yoshiki Senda, Kazunari Misawa, Yuich Ito, Norihisa Uemura, Seiji Natsume, Jiro Kawakami, Akira Ouchi, Masayuki Tsutsuyama, Takahiro Hosoi, Itaru Shigeyoshi, Tomoyuki Akazawa, Daisuke Hayashi, Hideharu Tanaka, Yasuhiro Shimizu
We report a long-term survivor of colorectal cancer who underwent aggressive, frequent resection for peritoneal recurrences. A 58-year-old woman was diagnosed with descending colon cancer. Resection of the descending colon along with lymph node dissection was performed in September 2006. The pathological findings revealed Stage IIA colorectal cancer. The following peritoneal recurrences were removed: two in July 2007, two in the omental fat and two in the pouch of Douglas in June 2008 resected by low anterior resection of the rectum, one in the uterus and right ovarian recurrence resected via bilateral adnexectomy and Hartmann's procedure in May 2011, and one in the ascending colon by partial resection of the colon wall in December 2011...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008205/prevalence-and-correlates-of-perceived-teeth-health-status-and-oral-health-behavior-among-school-going-adolescents-in-cambodia
#4
Karl Peltzer, Chher Tepirou, Supa Pengpid
The purpose of the study was to investigate perceived teeth health status and oral health behavior, as well as their correlates, among adolescents in Cambodia. The analysis included 3806 Cambodian school children (mean age 15.7 years, SD=1.8 years) who took part in the "Global School-based Student Health Survey" (GSHS) in 2013. Overall, 7.8% of the students reported poor perceived teeth status, 18.0% had missed school in the past year because of a toothache, 26.7% engaged in combined oral health behavior (brushing teeth twice daily or more often = 79...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008204/novel-and-recurrent-atp2a2-mutations-in-japanese-patients-with-darier-s-disease
#5
Kana Noda, Takuya Takeichi, Yusuke Okuno, Hiromichi Takama, Shunsuke Miura, Shinji Kagami, Haruko Hino, Yuki Nakamura, Yumi Fujio, Izumi Konohana, Ayako Otani, Hideki Mukai, Kazumitsu Sugiura, Masashi Akiyama
Darier's disease (DD, keratosis follicularis: OMIM#124200) is an autosomal dominant skin disorder characterized by multiple dark brown keratotic plaques and warty papules covered by thick crusts. Most cases of DD are caused by mutations in ATP2A2, which is expressed in both the skin and the brain. ATP2A2 encodes the cardiac muscle SERCA2a protein and the ubiquitously expressed SERCA2b. SERCA2 plays an important role as a calcium pump. It is thought that a mutation in ATP2A2 causes dyskeratosis and abnormality of cell-cell adhesion...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008203/prevalence-and-predictors-of-prediabetes-and-diabetes-among-adults-in-palau-population-based-national-steps-survey
#6
Esayas Haregot Hilawe, Chifa Chiang, Hiroshi Yatsuya, Chaochen Wang, Edolem Ikerdeu, Kaori Honjo, Takashi Mita, Renzhe Cui, Yoshihisa Hirakawa, Sherilynn Madraisau, Gregorio Ngirmang, Hiroyasu Iso, Atsuko Aoyama
We aimed to investigate the prevalence and predictors of diabetes and prediabetes among adults in Palau. We used data of 1915 adults, aged 25 to 64 years, who participated in the World Health Organization's (WHO) STEPwise Approach to Risk Factor Surveillance (STEPS) study in Palau. Information on behavioral risk factors of NCDs and physical and biochemical measurements were obtained using standard methods of the WHO. The diagnosis of diabetes and prediabetes was based on the recent American Diabetes Association criteria...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008202/investigation-of-single-nucleotide-variants-in-mbd5-associated-with-autism-spectrum-disorders-and-schizophrenia-phenotypes
#7
Kanako Ishizuka, Hiroki Kimura, Akira Yoshimi, Masahiro Banno, Itaru Kushima, Yota Uno, Takashi Okada, Daisuke Mori, Branko Aleksic, Norio Ozaki
MBD5 (Methyl-CpG-binding domain 5) is a critical gene for normal development. While deletion or duplication of MBD5 may contribute to a genetic predisposition to autism spectrum disorders (ASD), intellectual disability, or epilepsy, the impact of rare MBD5 single nucleotide variants (SNVs) on neurodevelopmental features, particularly features with late onset, has not been fully explored. In this study, we conducted exon-targeted resequencing of MBD5 with next-generation sequencing technology in 562 Japanese patients (192 with idiopathic ASD and 370 with schizophrenia (SCZ)) and detected 16 MBD5 SNVs with allele frequencies of ≤1%...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008201/active-brain-changes-after-initiating-fingolimod-therapy-in-multiple-sclerosis-patients-using-individual-voxel-based-analyses-for-diffusion-tensor-imaging
#8
Joe Senda, Hirohisa Watanabe, Kuniyuki Endo, Keizo Yasui, Yasuhiro Hawsegawa, Noritaka Yoneyama, Takashi Tsuboi, Kazuhiro Hara, Mizuki Ito, Naoki Atsuta, Bagarinao Epifanio, Masahisa Katsuno, Shinji Naganawa, Gen Sobue
Voxel-based analysis (VBA) of diffusion tensor images (DTI) and voxel-based morphometry (VBM) in patients with multiple sclerosis (MS) can sensitively detect occult tissue damage that underlies pathological changes in the brain. In the present study, both at the start of fingolimod and post-four months clinical remission, we assessed four patients with MS who were evaluated with VBA of DTI, VBM, and fluid-attenuated inversion recovery (FLAIR). DTI images for all four patients showed widespread areas of increased mean diffusivity (MD) and decreased fractional anisotropy (FA) that were beyond the high-intensity signal areas across images...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008200/comparing-surgical-outcomes-of-complete-thoracoscopic-lobectomy-for-congenital-cystic-lung-disease-between-neonatal-and-infantile-patients
#9
Takahisa Tainaka, Hiroo Uchida, Yujiro Tanaka, Chiyoe Shirota, Kazuki Yokota, Naruhiko Murase, Kazuo Oshima, Ryo Shirotsuki, Kosuke Chiba, Akinari Hinoki
Thoracoscopic lobectomy has recently become a widely used surgical treatment for congenital cystic lung disease, but significant issues can arise in some cases, such as a limited working space in neonates, a limited view in cases involving large cystic lesions. We reviewed the treatment outcomes of neonates that underwent complete thoracoscopic lobectomy or segmentectomy and evaluated the operative difficulties. From January 2008 to October 2015, 38 patients under the age of 1 year underwent complete thoracoscopic lobectomy or segmentectomy for cystic lung disease at our institution...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008199/magnetic-resonance-imaging-of-cardiac-sarcoidosis-an-evaluation-of-the-cardiac-segments-and-layers-that-exhibit-late-gadolinium-enhancement
#10
Tomohiro Komada, Kojiro Suzuki, Hiroaki Ishiguchi, Hisashi Kawai, Takahiro Okumura, Akihiro Hirashiki, Shinji Naganawa
Cardiac sarcoidosis (CS) can cause sudden death, which is the leading cause of mortality in patients with sarcoidosis in Japan. However, it is difficult to diagnose CS because of the lack of a sensitive diagnostic method for the condition. Late gadolinium-enhanced cardiac magnetic resonance (MR) imaging demonstrates improved sensitivity for diagnosing CS. Therefore, it is important to know the late gadolinium-enhancement (LGE) characteristics of CS on cardiac MR images in order to diagnose CS accurately. In this study, we investigated the most common sites of LGE on cardiac MR images in CS...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008198/anticipated-stigma-in-chronic-illness-patients-in-cambodia-myanmar-and-vietnam
#11
Karl Peltzer, Supa Pengpid
The aim of this study was to explore the prevalence and relationship of anticipated chronic illness stigma among patients diagnosed with a variety of chronic diseases in three Southeast Asian countries (Cambodia, Myanmar and Vietnam). A cross-sectional survey was conducted in 4,803 adult chronic disease patients (mean age 49.3 years; SD=16.5) recruited systematically from health facilities. Overall, the results indicate that 20.7% of patients reported that for any of the 12 stigma items, they anticipated they were likely or very likely to experience chronic disease stigma...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008197/associations-of-alcohol-use-with-mental-health-and-alcohol-exposure-among-school-going-students-in-cambodia
#12
Karl Peltzer, Supa Pengpid, Chher Tepirou
The aim of this study was to examine the associations of alcohol use with sociodemographic factors, mental health and alcohol exposure among school-going adolescents in Cambodia. The analysis included 3,806 school children, mean age 15.7 years (SD=1.8), from Cambodia who participated in the "Global School-based Student Health Survey" (GSHS) in 2013. The results indicate that overall, 10.0% of the students reported current alcohol use, 10.8% lifetime drunkenness, and 2.8% problem drinking. In multivariate logistic regression analysis, sociodemographic factors (older age and being male), mental health and other variables (bullying victimization, OR (odds ratio) = 1...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008196/clinical-characteristics-of-primary-peritoneal-carcinoma-patients-a-single-institution-experience-involving-8-patients
#13
Satomi Hattori, Hiroaki Kajiyama, Utako Fuji, Yuko Furui, Yuki Ishibashi, Yuka Hattori, Noriko Takahashi, Fumitaka Kikkawa, Toshiya Misawa
Primary peritoneal carcinoma (PPC) is treated similarly to advanced epithelial ovarian carcinoma (aEOC); however, the standard approach for the management of PPC is controversial. The objective of this study was to evaluate the clinical features and prognosis of those patients. A retrospective analysis was performed of eight patients with PPC between January 2008 and December 2015. Clinicopathologic parameters, the diagnostic modality, treatment, and oncologic outcome were analyzed. The median age at the time of diagnosis was 72...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008195/a-multicenter-survey-of-stage-t1-glottic-cancer-treated-with-radiotherapy-delivered-in-2-25-gy-fractions-in-clinical-practice-an-initial-5-year-analysis
#14
Yoshiyuki Itoh, Seiji Kubota, Mariko Kawamura, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Naoki Hirasawa, Akiko Asano, Shigeo Yanagawa, Shinji Naganawa
The purpose of this study was to evaluate the acute and late toxicity as well as local control (LC) in T1 glottic cancer (GC) patients treated with hypofractionated radiotherapy (RT) in clinical practice. The Tokai Study Group for Therapeutic Radiology and Oncology started RT treatment with a dose of 2.25 Gy for T1 GC in 2011. Ten institutions combined data from 104 patients with T1 squamous cell carcinoma between 2011 and 2015. In total, 104 patients with T1 GC were irradiated with a standard radiation dose of 63 Gy in 28 fractions...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008194/role-of-courtyard-counselling-meeting-in-improving-household-food-safety-knowledge-and-practices-in-munshiganj-district-of-bangladesh
#15
Baizid Khoorshid Riaz, Md Abdul Alim, Anm Shamsul Islam, Km Bayzid Amin, Mohammad Abul Bashar Sarker, Khaled Hasan, Md Noor Ashad-Uz-Zaman, Shahjada Selim, Salman Quaiyum, Emdadul Haque, Shah Monir Hossain, John Ryder, Rokeya Khanam
Unsafe food is linked to the deaths of an estimated two million people annually. Food containing harmful agents is responsible for more than 200 diseases ranging from diarrhoea to cancers. A one-sample pilot intervention study was conducted to evaluate the role of courtyard counselling meetings as the means of intervention for improving food safety knowledge and practices among household food handlers in a district of Bangladesh. The study was conducted in three phases: a baseline survey, the intervention and an end-line survey between April and November 2015 where 194 food handlers took part...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008193/associations-between-proteinuria-and-cardiovascular-risk-factors-among-hypertensive-patients-in-andkhoy-afghanistan
#16
Mohammad Shoaib Hamrah, Mohammad Hashem Hamrah, Hideki Ishii, Susumu Suzuki, Mohammad Hussain Hamrah, Mohammad Hassan Hamrah, Maimaiti Yisireyili, Naoaki Kano, Kyosuke Takeshita, Junichi Sakamoto, Toyoaki Murohara
Proteinuria in hypertension is an early marker of renal disease and a predictor for the progression of end stage renal disease, and cardiovascular diseases. This study was designed to determine the prevalence of proteinuria and its association with cardiovascular risk factors among adult hypertensive patients in Afghanistan. Five hundred fifty-five patients with a high blood pressure recorded in an outpatient clinic in Andkhoy, Afghanistan from December 2014 to May 2015, were included in this study. Data obtained from each patient, included demographic characteristics, body mass index, blood pressure patterns, cardiovascular history, cardiovascular risk factors, comorbidity, and current drug-therapy...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008192/the-long-term-results-and-changing-patterns-of-biological-valves-at-the-mitral-position-in-contemporary-practice-in-japan
#17
Tomonobu Abe, Hideki Ito, Masato Mutsuga, Kazuro Fujimoto, Sachie Terazawa, Yuji Narita, Hideki Oshima, Akihiko Usui
Mitral valve surgery has changed with the wide acceptance of mitral valve repair. The aim of this study is to obtain the long-term results of patients who underwent mitral valve replacement (MVR) using a biological prosthesis in contemporary practice in Japan. From January 1990 to December 2013, 76 patients underwent MVR using a biological prosthesis with or without concomitant surgery. Data were obtained by means of a questionnaire and a telephone interview. The mean follow-up period was 4.26 years. The etiologies of the patients included dilated cardiomyopathy (DCM) (n=20 [26...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008191/abnormal-urinalysis-on-day-7-in-patients-with-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura
#18
Nozomu Kawashima, Jun-Ichi Kawada, Yuichi Nishikado, Yuma Kitase, Sanae Ito, Hideki Muramatsu, Yoshiaki Sato, Taichi Kato, Jun Natsume, Seiji Kojima
Rare progression to renal failure imposes a burden on children with IgA vasculitis (Henoch-Schönlein purpura, HSP). An abnormal urinalysis on day 7 (7d-UA) may be a surrogate marker for persistent nephritis, but this has not been established. We retrospectively analyzed the risk factors for persistent nephritis in a cohort of 138 children. Of 35 children with abnormal 7d-UA, 24 (69%) had an abnormal urinalysis 6 months after the diagnosis of HSP, which was significantly more than 6 of 103 children (6%) with normal 7d-UA (P < 0...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008190/central-diabetes-insipidus
#19
REVIEW
Hiroshi Arima, Yoshinori Azuma, Yoshiaki Morishita, Daisuke Hagiwara
Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous study suggests that infundibulo-neurohypophysitis might be an underlying cause of idiopathic CDI. Among secondary CDI, the tumors in the central nervous system such as craniopharyngioma and germ cell tumors are the most frequent causes...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28008189/german-japanese-relationships-in-biochemistry-a-personal-perspective
#20
Helmut Sies
The first Institute of Biochemistry in Japan was founded by Leonor Michaelis from Berlin at Nagoya in 1922, and there have been numerous interrelations between Japanese and German biochemists since. Some such relationships are presented here from a personal point of view as one illustrative example, which could be extended amply by the experience of many other scientists from the two countries. Fruitful exchanges are facilitated by organisations such as the Alexander von Humboldt Foundation (AvH) and the Deutscher Akademischer Austauschienst (DAAD) or the Japanese Society for the Promotion of Science (JSPS) and by the many bilateral agreements between universities and research institutions...
December 2016: Nagoya Journal of Medical Science
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