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Nagoya Journal of Medical Science

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https://www.readbyqxmd.com/read/29915446/refractory-hypotension-due-to-nivolumab-induced-adrenal-insufficiency
#1
Yoshiaki Tsukizawa, Keisuke Kondo, Toshihisa Ichiba, Hiroshi Naito, Kazuhito Mizuki, Ken Masuda
Nivolumab, a new immune checkpoint inhibitor that has been found to improve outcomes for patients with some advanced cancers, is being increasingly used. Immune checkpoint inhibitors can cause immune-related adverse events, including dermatitis, enterocolitis, hepatitis and hypophysitis, but adrenal insufficiency rarely occurs. We present a case of Nivolumab-induced adrenal insufficiency in a man who complained of refractory hypotension. A 52-year-old man with non-small cell lung cancer visited our emergency department complaining of fatigue and diarrhea...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915445/high-resolution-cone-beam-ct-for-evaluation-of-vascular-channel-in-intracranial-partial-thrombosed-aneurysm
#2
Kazunori Shintai, Noriaki Matsubara, Takashi Izumi
The authors present a 60-year-old man with a partially thrombosed, intracranial vertebral artery aneurysm. A vascular channel in intra-aneurysmal thrombus was effectively identified with high-resolution cone beam CT (DynaCT Micro: Siemens Medical Solutions, Erlangen, Germany). Pre-procedural vertebral angiogram implied a perforating artery arising from near neck of the aneurysm and DynaCT Micro performed before approaching to the lesion demonstrated a vascular channel running in intra-aneurysmal thrombus which could not be distinguished from perforators with other imaging modalities...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915444/analysis-of-genotype-phenotype-correlations-in-japanese-patients-with-dyschromatosis-symmetrica-hereditaria
#3
Tomoko Kobayashi, Michihiro Kono, Mutsumi Suganuma, Hirotaka Akita, Ayaka Takai, Kiyohiro Tsutsui, Yu Inasaka, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama
Dyschromatosis symmetrica hereditaria (DSH) is one of the genetic pigmentation disorders and shows characteristic mixture of hyper- and hypo-pigmented small macules on the extremities. Heterozygous mutations in the adenosine deaminase acting on RNA1 gene ( ADAR1 ) cause DSH. In the present study, we report five cases of DSH and identify a distinct known mutation in each patient. Furthermore, we review previously described cases with the five ADAR1 mutations found in the present study. We reviewed clinical and molecular findings in the present and previously reported cases and found an identical mutation can result in various phenotypic severities, even in one family...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915443/fecal-calprotectin-reflects-endoscopic-activity-in-patients-with-small-bowel-crohn-s-disease-according-to-double-balloon-endoscopy-findings
#4
Rinzaburo Matsuura, Osamu Watanabe, Masanao Nakamura, Takeshi Yamamura, Masanobu Matsushita, Hiroki Suhara, Kazuhiro Furukawa, Takuya Ishikawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto
Fecal calprotectin (FC) has drawn attention as a biomarker in the evaluation of Crohn's disease (CD). However, few reports have provided a detailed examination of the relationship between small-bowel CD lesions and FC levels. The present study aimed to examine the entire small bowel using double-balloon endoscopy (DBE) and to determine the relationship between the endoscopic activity in small-bowel CD and FC levels. Twenty small-bowel CD patients, who underwent DBE, were prospectively enrolled. Endoscopic evaluation was based on the simple endoscopic score for CD, with the small bowel divided into four regions...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915442/left-ventricular-hypertrophy-and-proteinuria-in-patients-with-essential-hypertension-in-andkhoy-afghanistan
#5
Mohammad Shoaib Hamrah, Mohammad Hassan Hamrah, Hideki Ishii, Susumu Suzuki, Mohammad Hussain Hamrah, Ahmad Edris Hamrah, Ahmad Elias Dahi, Maimaiti Yisireyili, Naoaki Kano, Kyosuke Takeshita, Mohammad Hashem Hamrah, Junichi Sakamoto, Toyoaki Murohara
Left ventricular hypertrophy (LVH) and proteinuria are known as independent predictors of cardiovascular death in hypertension. However, LVH and its association with proteinuria have not been investigated in adult hypertensive patients in Afghanistan. The objective of this research was to determine the prevalence of LVH and the correlation between LVH and proteinuria among the Afghan adult hypertensive population visiting an outpatient clinic in Afghanistan. We retrospectively evaluated 789 hypertensive patients (mean age is 56 years and 46% were men) who visited the clinic between December 2014 and August 2016...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915441/dengue-fever-during-pregnancy
#6
Trinh Tien Dat, Tomomi Kotani, Eiko Yamamoto, Kiyosumi Shibata, Yoshinori Moriyama, Hiroyuki Tsuda, Mamoru Yamashita, Hiroaki Kajiyama, Dien Duc Thien Minh, Le Quang Thanh, Fumitaka Kikkawa
Dengue fever during pregnancy is an expanding issue in Southeast Asia; however, the knowledge of adverse effects on mothers and neonates remains limited. Therefore, we aimed to determine the impact of dengue fever. The clinical information of 20 patients of dengue fever during pregnancy in Vietnam from January 1, 2015 to December 31, 2015 was collected and their outcomes were retrospectively investigated. A total of 18 patients (90%) presented with positivity of nonstructural protein 1, and a primary infection...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915440/waiting-time-in-the-outpatient-clinic-at-a-national-hospital-in-vietnam
#7
Suong Thi Thao Nguyen, Eiko Yamamoto, Mai Thi Ngoc Nguyen, Huy Bao Le, Tetsuyoshi Kariya, Yu Mon Saw, Cong Duc Nguyen, Nobuyuki Hamajima
Vietnam is facing a problem of over-crowding in public hospitals. Long waiting time is a major dissatisfaction for patients. Reducing waiting time benefits not only patients but also hospitals in decreasing overall workload. To identify factors contributing to long waiting time in outpatient clinics, a cross-sectional study was conducted at a national hospital in Vietnam. The time for each process of 7,931 patients who visited the outpatient clinics within Thong Nhat Hospital from 5 to 9 September 2016 was collected from the computerized clinical database...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915439/%C3%AF-editors-choice%C3%AF-practice-management-for-elderly-patients-with-breast-cancer-findings-from-a-survey-by-the-japan-breast-cancer-study-group
#8
Masataka Sawaki, Kenji Tamura, Akihiko Shimomura, Yumiko Taki, Fumio Nagashima, Hiroji Iwata
Information on patterns of clinical care for elderly breast cancer patients is lacking. The aims of this study are two-fold, firstly, to clarify daily practice treatments for elderly breast cancer patients in Japan, and secondly, to plan a prospective clinical trial to address unresolved clinical questions. We investigated practice care of elderly breast cancer patients in 38 institutions of the Japan Clinical Oncology Group (JCOG). Questionnaires asked: (1) definition of "elderly" for each treatment, (2) clinical standard anti-HER2 therapy in each age-group, (3) recommended docetaxel dose in each age-group, (4) considerations for future clinical trials, and (5) other information about geriatric oncology concerning breast cancer...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915438/association-between-cyp2c19-genotype-and-the-additional-effect-of-cilostazol-to-clopidogrel-resistance-in-neuroendovascular-therapy
#9
Hayato Tajima, Takashi Izumi, Shigeru Miyachi, Noriaki Matsubara, Masashi Ito, Tasuku Imai, Masahiro Nishihori, Kazunori Shintai, Sho Okamoto, Yoshio Araki, Yasuo Kumakura, Yoko Furukawa-Hibi, Kiyofumi Yamada, Toshihiko Wakabayashi
We investigated the association between CYP2C19 genotype and additional effect of cilostazol on clopidogrel resistance (CR) in neuroendovascular therapy. Between January 2012 and January 2016, 447 consecutive patients were administered with 75-mg cilostazol/day. The VerifyNow System was used for evaluating P2Y12 reaction units (PRU) > 230 and/or percentage inhibition of platelet function (% Inhibition) ≤ 20 as CR. Among 158 patients with CR, 31 were administered with additional 100- or 200-mg cilostazol/day and their platelet function was evaluated...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915437/adult-distal-humerus-trauma-with-surgical-intervention-ct-analysis-of-fracture-pattern-causes-and-distribution
#10
Tatsunori Mitake, Takanobu Nishizuka, Masahiro Tatebe, Hitoshi Hirata
This multicenter cross-sectional study aimed to determine the differences in distribution and fracture pattern between low-energy and high-energy groups in distal humeral fractures in Japan. Retrospectively, 133 patients (48 males, 85 females) with distal humeral fractures were enrolled in this study. The age, sex, fracture classification, injury mechanism, preoperative therapy for osteoporosis, and nature of soft-tissue injury were recorded for all patients. The Mann-Whitney U test and chi-square test or Fisher's exact test were used for non-normally distributed variables and categorical variables, respectively, to compare differences between the two groups...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915436/assessment-of-tumor-response-to-neoadjuvant-chemotherapy-in-patients-with-breast-cancer-using-mri-and-fdg-pet-ct-recist-1-1-vs-percist-1-0
#11
Kazuhiro Kitajima, Yasuo Miyoshi, Toshiko Yamano, Soichi Odawara, Tomoko Higuchi, Koichiro Yamakado
Therapeutic response to neoadjuvant chemotherapy (NAC) for breast cancer based on Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) 1.0 with FDG-PET/CT measurements was evaluated, and the results compared to those obtained with currently widely used Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, based on MRI measurements. MRI and FDG-PET/CT examinations were performed in 32 breast cancer patients before and after the NAC prior to a surgical resection. Chemotherapeutic response of the primary tumor and relapse-free survival (RFS) were investigated using RECIST 1...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915435/lifestyle-intervention-using-internet-of-things-iot-for-the-elderly-a-study-protocol-for-a-randomized-control-trial-the-best-life-study
#12
Sawako Kato, Masahiko Ando, Takaaki Kondo, Yasuko Yoshida, Hiroyuki Honda, Shoichi Maruyama
Modification of lifestyle habits, including diet and physical activity, is essential for the prevention and control of type 2 diabetes mellitus (T2DM) in elderly patients. However, individualized treatment is more critical for the elderly than for general patients. This study aimed to determine lifestyle interventions that resulted in lowering hemoglobin A1c (HbA1c ) in Japanese pre- and early diabetic elderly subjects. The BEST-LIFE trial is an ongoing, open-label, 6-month, randomized (1:1) parallel group trial...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915434/inadequate-water-treatment-quality-as-assessed-by-protozoa-removal-in-sarawak-malaysia
#13
Nguk Ting Lo, Mohammad Abul Bashar Sarker, Yvonne Ai Lian Lim, Md Harun-Or-Rashid, Junichi Sakamoto
Providing safe drinking-water to human civilization is indispensable; it is one of the most cost-effective means of reducing the disease burden of diarrhea. Unfortunately, water supply quality monitoring from public water treatment plants (WTPs) is often neglected or taken for granted. To determine the produced water quality, WTPs in Sarawak, Malaysia were assessed for their protozoa removal ability. A self-administered questionnaire based on the regulations in the Drinking-water Standards for New Zealand (DWSNZ) was developed...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915433/factors-related-to-mental-health-and-hearing-in-community-dwelling-elderly
#14
Sumiyo Nabeshima, Kiyomi Yamada
The purpose of this study was to clarify the factors related to mental health and hearing in community-dwelling elderly. Elderly participants in a project to prevent long-term care need were given a self-administered questionnaire and tested by pure-tone audiometry. One hundred fifty were taken as subjects. Forty-one of these subjects (27.3%) were found to have poor mental health. The results of multiple logistic regression analysis with mental health level as the dependent variable indicated that subjects 65-74 years old who did not think their own hearing was bad had better mental health than those who did think their hearing was bad (odds ratio 10...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915432/%C3%AF-editors-choice%C3%AF-effects-of-exosomes-derived-from-the-induced-pluripotent-stem-cells-on-skin-wound-healing
#15
Hitoshi Kobayashi, Katsumi Ebisawa, Miki Kambe, Takatoshi Kasai, Hidetaka Suga, Kae Nakamura, Yuji Narita, Aika Ogata, Yuzuru Kamei
Recently, the effects of stem cell supernatants or exosomes, such as skin wounds, have attracted attention. However, the effects of the induced pluripotent stem (iPS) cell-derived exosomes (iPS-Exos) have not been investigated in detail. Here, we investigated the effects of iPS-Exos on skin wound healing using an animal model. We isolated iPS-Exos from the iPS cell culture media. Control exosomes were isolated from unused iPS cell culture media (M-Exos). We first observed the morphologic characteristics of the isolated exosomes and examined the expression of surface antigens...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29581623/a-case-of-local-recurrence-of-t1-rectal-cancer-10-years-after-transanal-excision
#16
Hideharu Tanaka, Koji Komori, Takashi Kinoshita, Taihei Oshiro, Seiji Ito, Tetsuya Abe, Yoshiki Senda, Kazunari Misawa, Yuichi Ito, Norihisa Uemura, Seiji Natsume, Eiji Higaki, Akira Ouchi, Masayuki Tsutsuyama, Takahiro Hosoi, Itaru Shigeyoshi, Byonggu An, Tomoyuki Akazawa, Daisuke Hayashi, Tairin Uchino, Aina Kunitomo, Yasuhiro Shimizu
We report a case of a patient with T1 rectal cancer, which recurred locally after 10 years from the primary operation. A 78-year-old woman was diagnosed with rectal cancer. Transanal excision (TAE) was performed in December 2006. The pathological findings revealed stage I rectal cancer [tub2>muc, pSM (2,510 µm), ly0, v0, pHM0, pVM0]. Because she did not opt for additional treatment, she received follow-up examination. After approximately 10 years from the primary operation, she presented to her physician, complaining of melena, and she was referred to our hospital again in November 2016...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29581622/bevacizumab-induced-tracheoesophageal-fistula-in-a-patient-suffering-from-lung-cancer-with-bulky-subcarinal-lymph-node-a-case-report
#17
Kenichi Nishie, Masanori Yasuo, Yoshiaki Kitaguchi, Nobumitsu Kobayashi, Kazunari Tateishi, Atsuhito Ushiki, Kazuhisa Urushihata, Hiroshi Yamamoto, Gen Ideura, Masayuki Hanaoka
A 66-year-old male with advanced non-small-cell lung cancer (NSCLC) who was previously treated with carboplatin, pemetrexed, and bevacizumab consequently suffered from severe coughing during deglutition. Chest computed tomography (CT) revealed a tracheoesophageal fistula (TEF) between the left main bronchus and esophagus through a subcarinal metastatic lymph node. Given the extreme swelling of the lymph node due to metastatic cancer, it was determined that the walls of the bronchus and esophagus had been injured simultaneously...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29581621/clinical-significance-of-gastrointestinal-patency-evaluation-by-using-patency-capsule-in-crohn-s-disease
#18
Toru Yoshimura, Yoshiki Hirooka, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Masanobu Matsushita, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto
Capsule endoscopy (CE) enables noninvasive visualization of the small bowel in Crohn's disease (CD), but should not be conducted in patients with bowel obstruction. Patency capsule (PC) can be ingested before conducting the CE examination to ensure patency of the gastrointestinal (GI) tract. This study aimed to evaluate the clinical significance of GI patency which the PC demonstrated. A retrospective review of the medical records was conducted with 99 consecutive patients with CD who underwent PC and CE at Nagoya University Hospital from January 2010 to May 2015...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29581620/genome-wide-association-study-for-pollinosis-identified-two-novel-loci-in-interleukin-il-1b-in-a-japanese-population
#19
Ryosuke Fujii, Asahi Hishida, Michael C Wu, Takaaki Kondo, Yuta Hattori, Mariko Naito, Kaori Endoh, Masahiro Nakatochi, Nobuyuki Hamajima, Michiaki Kubo, Kiyonori Kuriki, Kenji Wakai
The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated with self-reported pollinosis in a Japanese population and to understand its molecular background using a combination of single nucleotide polymorphisms (SNPs) and gene- and pathway-based analyses...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29581619/identifying-the-social-capital-influencing-diabetes-control-in-japan
#20
Yohei Yamada, Mina Suematsu, Noriyuki Takahashi, Kentaro Okazaki, Hiroki Yasui, Takeshi Hida, Kazumasa Uemura, Kenta Murotani, Masafumi Kuzuya
The number of patients with diabetes is increasing in Japan. Recently, Social capital (SC) has received increasing attention as a factor influencing health conditions. In the US, the relation between SC and diabetes control has been reported, but little attention has been paid to this connection in Japan. Three SC questionnaires, entitled "trust in people in a community," "social support," and "social relationships," were constructed. The subjects were adult patients with type 2 diabetes...
February 2018: Nagoya Journal of Medical Science
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