journal
https://read.qxmd.com/read/38155634/laparoscopic-and-endoscopic-cooperative-surgery-as-palliative-treatment-for-elderly-patients-with-gastric-cancer
#1
Masayuki Urabe, Yasuhiro Okumura, Asami Okamoto, Koichi Yagi, Yosuke Tsuji, Hiroharu Yamashita, Mitsuhiro Fujishiro, Yasuyuki Seto
Oncological gastrectomy, despite remaining a mainstay of gastric cancer treatment, is reportedly associated with high morbidity and mortality in elderly patients. Less invasive modalities suitable for senior gastric cancer patients with insufficient surgical tolerance are thus needed. We adopted laparoscopic and endoscopic cooperative surgery as an alternative for elderly gastric cancer cases unsuitable for aggressive gastrectomy. To date, we have experienced three cases (80-86 years old) undergoing palliative laparoscopic and endoscopic cooperative surgery...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155633/validity-and-reliability-of-the-posttraumatic-growth-inventory-among-japanese-women-with-cesarean-section
#2
JOURNAL ARTICLE
Asuka Suzuki, Shigemi Iriyama, Yoko Obayashi
This study aimed to examine the validity and reliability of the expanded version of the Posttraumatic Growth Inventory-Japanese version (PTGI-X-J) among Japanese women who delivered by cesarean section. The study is a cross-sectional survey psychometric study. Participants were 517 Japanese women who were in the hospital after childbirth by cesarean section at six general hospitals and two obstetric clinics in Tokai Region, Japan. They completed a self-report questionnaire-which included sociodemographic and childbirth information and obstetric history, the PTGI-X-J, and the Postnatal Women Version of the Japanese-Language Version of the Impact of Event Scale-Revised (IES-R-J-PWV)...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155632/an-autopsy-case-of-primary-gliosarcoma-with-multiple-extracranial-metastases-pathology-after-administration-of-bevacizumab-and-genetic-profile
#3
Yoshiki Sato, Shoichi Deguchi, Tomoko Norose, Takuma Oishi, Koichi Mitsuya, Takashi Sugino, Yasuto Akiyama, Takeshi Nagashima, Kenichi Urakami, Yuji Shimoda, Keiichi Ohshima, Nakamasa Hayashi, Ken Yamaguchi
Gliosarcoma (GS), a morphological variant of glioblastoma, pathologically shows a biphasic pattern with gliomatous and sarcomatous components. It has been reported that GS has much higher metastatic capacity than glioblastoma. A few reports on the pathology of the extracranial metastasis of GS have shown that metastatic lesions had a sarcomatous component alone or a mixture of gliomatous and sarcomatous ones. Therefore, it is considered that GS tends to disseminate hematogenously due to its mesenchymal sarcomatous component...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155631/hand-function-and-quality-of-life-in-patients-with-diabetes-mellitus-before-and-during-the-covid-19-pandemic
#4
JOURNAL ARTICLE
Michiro Yamamoto, Yayoi Kato, Jun Takeuchi
This study aimed to investigate the effects of the coronavirus disease 2019 (COVID-19) pandemic on patients with diabetes mellitus using patient-rated outcome measures focusing on hand function and quality of life, as well as patients' mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. It was a part of a longitudinal research involving patients with diabetes mellitus living in Sapporo, Japan. Among the 594 patients surveyed before the COVID-19 pandemic from March to June 2019, 417 patients who could be re-surveyed from March to June 2021 were included...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155630/ultra-high-density-mapping-for-safe-and-effective-typical-atrioventricular-nodal-reentrant-tachycardia-ablation
#5
Yusuke Sakamoto, Hiroyuki Osanai
Ultra-high-density mapping was used for potential-guided radiofrequency ablation for typical atrioventricular nodal reentrant tachycardia. The mapping detailed the spread of activation in the Koch's triangle and identified target potentials and tachycardia circuits. This mapping provides additional information to the slow pathway conventionally used for safe and effective ablation.
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155629/surgical-reconstruction-after-resection-of-cardiac-metastasis-from-oropharyngeal-carcinoma-a-case-report
#6
Toshihiko Nishi, Kazuro L Fujimoto, Mariko Hiramatsu, Tohru Okada, Yuka Suzuki, Yoshie Shimoyama, Sachie Terazawa, Yoshiyuki Tokuda, Masato Mutsuga, Akihiko Usui
No abstract text is available yet for this article.
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155628/difference-of-coil-distribution-made-by-finishing-coils-in-large-size-aneurysm-model-with-radiolucent-coils
#7
JOURNAL ARTICLE
Hiroki Matsuno, Takashi Izumi, Masahiro Nishihori, Shunsaku Goto, Yoshio Araki, Kinya Yokoyama, Kenji Uda, Ryuta Saito
We conducted a study to understand the characteristics of the finishing coils to select the appropriate coil for the final stage of embolization. Consequently, experimental embolization was performed on a 10 mm spherical silicone aneurysm filled with radiolucent coils, which simulated a volume embolization ratio of 20%. Nine different coils (i-ED complex ∞ SilkySoft, SilkySoft, ExtraSoft, V-Trak HyperSoft helical, Barricade 10 complex finishing, Optima complex 10 soft, Target 360 Ultra, Galaxy G3 mini, and Axium prime 3D ExtraSoft) were analyzed six times at random...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155627/creation-of-synthetic-contrast-enhanced-computed-tomography-images-using-deep-neural-networks-to-screen-for-renal-cell-carcinoma
#8
JOURNAL ARTICLE
Naoto Sassa, Yoshitaka Kameya, Tomoichi Takahashi, Yoshihisa Matsukawa, Tsuyoshi Majima, Katsuhisa Tsuruta, Ikuo Kobayashi, Keishi Kajikawa, Hideji Kawanishi, Haruka Kurosu, Sho Yamagiwa, Masaya Takahashi, Kazuhiro Hotta, Keiichi Yamada, Tokunori Yamamoto
In this study, we elucidate if synthetic contrast enhanced computed tomography images created from plain computed tomography images using deep neural networks could be used for screening, clinical diagnosis, and postoperative follow-up of small-diameter renal tumors. This retrospective, multicenter study included 155 patients (artificial intelligence training cohort [n = 99], validation cohort [n = 56]) who underwent surgery for small-diameter (≤40 mm) renal tumors, with the pathological diagnosis of renal cell carcinoma, during 2010-2020...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155626/t-cell-receptor-engineered-t-cells-derived-from-target-human-leukocyte-antigen-dpb1-specific-t-cell-can-be-a-potential-tool-for-therapy-against-leukemia-relapse-following-allogeneic-hematopoietic-cell-transplantation
#9
JOURNAL ARTICLE
Naoya Katsuyama, Takakazu Kawase, Carolyne Barakat, Shohei Mizuno, Akihiro Tomita, Kazutaka Ozeki, Nobuhiro Nishio, Yoshie Sato, Ryoko Kajiya, Keiko Shiraishi, Yoshiyuki Takahashi, Tatsuo Ichinohe, Hiroyoshi Nishikawa, Yoshiki Akatsuka
Human leukocyte antigen (HLA)-DPB1 antigens are mismatched in approximately 70% of allogeneic hematopoietic stem cell transplantations (allo-HSCT) from HLA 10/10 matched unrelated donors. HLA-DP-mismatched transplantation was shown to be associated with an increase in acute graft-versus-host disease (GVHD) and a decreased risk of leukemia relapse due to the graft-versus-leukemia (GVL) effect. Immunotherapy targeting mismatched HLA-DP is considered reasonable to treat leukemia following allo-HCT if performed under non-inflammatory conditions...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155625/a-case-of-simultaneous-breast-cancer-and-ovarian-cancer-based-on-a-hereditary-breast-and-ovarian-cancer-syndrome
#10
Saki Kotaka, Hiroaki Yasui, Hirofumi Tsubouchi, Masahiko Mori, Haruru Kotani, Akiyo Yoshimura, Akira Ouchi, Masataka Okuno, Koji Komori, Yasuhiro Shimizu, Shiro Suzuki
We experienced a relatively rare case of synchronous breast and ovarian cancer in a patient with hereditary breast and ovarian cancer syndrome (HBOC). Here, we report the usefulness of laparoscopic examination to determine the subsequent treatment strategy in cases of suspected concurrent multiple carcinomas. Our patient was diagnosed with breast cancer following detection of a right breast mass. She was diagnosed with HBOC as she was found to be harboring a germline pathogenic variant of breast cancer susceptibility gene 1 ( BRCA1 )...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155624/%C3%AF-editors-choice%C3%AF-pattern-of-thk-5351-retention-in-normal-aging-involves-core-regions-of-resting-state-networks-associated-with-higher-cognitive-function
#11
JOURNAL ARTICLE
Yusuke Yoshida, Takamasa Yokoi, Kazuhiro Hara, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Toshiyasu Kato, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Masahisa Katsuno, Katsuhiko Kato, Shinji Naganawa, Nobuyuki Okamura, Kazuhiko Yanai, Gen Sobue
We aimed to elucidate the distribution pattern of the positron emission tomography probe [18F]THK 5351, a marker for astrogliosis and tau accumulation, in healthy aging. We also assessed the relationship between THK5351 retention and resting state networks. We enrolled 62 healthy participants in this study. All participants underwent magnetic resonance imaging/positron emission tomography scanning consisting of T1-weighted images, resting state functional magnetic resonance imaging, Pittsburgh Compound-B and THK positron emission tomography...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155623/three-cases-of-open-surgical-procedures-on-ileal-conduits-for-the-repair-of-benign-ureteroenteric-anastomotic-strictures-after-total-pelvic-exenteration-of-rectal-tumors
#12
Koji Komori, Takashi Kinoshita, Yusuke Sato, Akira Ouchi, Seiji Ito, Tetsuya Abe, Kazunari Misawa, Yuichi Ito, Seiji Natsume, Eiji Higaki, Tomonari Asano, Masataka Okuno, Hironori Fujieda, Satoshi Oki, Tsukasa Aritake, Kakeru Tawada, Satoru Akaza, Hisahumi Saito, Kiyoshi Narita, Hiroki Kawabata, Yasuhiro Shimizu
Ureteroenteric anastomotic strictures (UEAS) are typical complications after creating an ileal conduit for total pelvic exenteration (TPE) of rectal tumors. We report the ileal conduit for reconstruction in three patients, in the age-range of 47-73 years. Case 1 was when a left-sided UEAS had sufficient length of ureter for anastomosis, Case 2 was a right-sided UEAS with sufficient length of ureter for anastomosis, and Case 3 was a left-sided UEAS with insufficient length of ureter for anastomosis. There were no complications after operation and no recurrence of UEAS...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155622/microglial-process-dynamics-depend-on-astrocyte-and-synaptic-activity
#13
JOURNAL ARTICLE
Ako Ikegami, Daisuke Kato, Hiroaki Wake
Microglial processes survey the brain parenchyma, but it is unknown whether this process is influenced by the cell activity of nearby microglia under physiological conditions. Herein, we showed that microglial process dynamics differ when facilitated by astrocytic activity and pre-synaptic activity. The results revealed distinct microglial process dynamics associated with the activity of other brain cells.
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155621/current-status-of-and-future-issues-related-to-endoscopic-papillectomy
#14
REVIEW
Hiroki Kawashima, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Takeshi Yamamura, Kazuhiro Furukawa, Masanao Nakamura
Endoscopic papillectomy is widely performed to treat duodenal papillary tumors, particularly at high-volume centers. It is indicated for adenomas without intraductal extension of the bile or pancreatic ducts. However, despite numerous reports of carcinomas that expand the indications to include well-differentiated adenocarcinomas that do not invade the sphincter of Oddi, the low agreement between biopsy and final pathological diagnosis, as well as the current inability of imaging modalities to diagnose sphincter of Oddi invasion, makes it difficult to consider expanding indications...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155620/association-of-the-age-at-smoking-initiation-and-cessation-on-all-cause-and-cause-specific-mortality-the-japan-collaborative-cohort-study
#15
JOURNAL ARTICLE
Sulaiman Haares Zuhal, Takashi Kimura, Akiko Tamakoshi
We estimated the association between the age at smoking initiation and cessation and all-cause and cause-specific mortality among Japanese men (n = 41,711; age 40-79 years) by analyzing data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risks. From 1988 and 1990 to 2009, 13,429 all-cause deaths (cancers, n = 4999; cardiovascular diseases, n = 3682) occurred in this cohort. Fitted Cox proportional hazard models, with never smokers as the reference group, were created. Former smokers demonstrated a lower risk for all-cause and cause-specific mortality than current smokers, with a dose-dependent reduction in the risk based on smoking-initiation age...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155619/characteristics-of-adverse-drug-reactions-due-to-nonsteroidal-anti-inflammatory-drugs-a-cross-sectional-study
#16
JOURNAL ARTICLE
Cholticha Sonsupap, Pattreya Pokhakul, Tetsuyoshi Kariya, Yunosuke Suzuki, Nobuyuki Hamajima, Eiko Yamamoto
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for treating pain and inflammation. Spontaneous adverse drug reaction (ADR) reports represent a rich data source for the detection of unknown and rare ADRs. This cross-sectional study aimed to analyze the characteristics of ADRs due to NSAIDs in Thailand. All ADR reports of NSAIDs for systemic use from 2015 to 2019 were extracted from the national database in Thailand. Patient characteristics, drug use information, adverse event information, and source of senders in 32,857 reports were analyzed...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155618/ruptured-breast-implant-removal-because-of-patient-anxiety-in-the-absence-of-breast-implant-associated-anaplastic-large-cell-lymphoma
#17
Hitomi Takahashi, Hideyoshi Sato, Yukiyo Tsunekawa, Urara Fujioka, Yumi Wanifuchi-Endo, Tatsuya Toyama, Kazuhiro Toriyama
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has been regarded as a long-term problem after silicone breast implantations. We report a case in which BIA-ALCL and breast cancer were not detected preoperatively, with subsequent removal of a ruptured breast implant. A 52-year-old woman had silicone breast implants on both sides for breast augmentation 15 years ago. Right axillary lymphadenopathy and intracapsular ruptures were noted by magnetic resonance imaging. Right axillary lymph node biopsy was performed at our department of breast surgery...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155617/efficacy-of-endoscopic-cricopharyngeal-myotomy-using-a-curved-rigid-laryngoscope-in-patients-with-sporadic-inclusion-body-myositis-four-retrospective-case-reviews
#18
Mayu Shigeyama, Naoki Nishio, Sayaka Yokoi, Nobuaki Mukoyama, Akihisa Wada, Takashi Maruo, Seiya Noda, Ayuka Murakami, Takashi Tsuboi, Masahisa Katsuno, Yasushi Fujimoto, Michihiko Sone
Sporadic inclusion body myositis (s-IBM) is an acquired degenerative inflammatory myopathy that leads to slowly progressive muscle weakness and atrophy of the limbs, face, and pharynx. Owing to the slow progression of the disease, the indications for surgical intervention remain unclear. Herein, we retrospectively reviewed the records of four patients with s-IBM who had undergone cricopharyngeal myotomy for severe dysphagia at our institution between 2016 and 2021. Among these, one patient underwent transcervical cricopharyngeal myotomy and laryngeal suspension, as videofluoroscopic examination of swallowing revealed poor laryngeal elevation...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155616/%C3%AF-editors-choice%C3%AF-mesenchymal-stem-stromal-cells-generated-from-induced-pluripotent-stem-cells-are-highly-resistant-to-senescence
#19
JOURNAL ARTICLE
Tomonori Aoi, Akihito Tanaka, Kazuhiro Furuhashi, Makoto Ikeya, Asuka Shimizu, Yuko Arioka, Itaru Kushima, Norio Ozaki, Shoichi Maruyama
The use of mesenchymal stem/stromal cells (MSCs) has attracted attention in the field of regenerative medicine based on their anti-inflammatory and tissue repair-promoting effects. Bone marrow is widely used as a source of MSCs; however, the performance of bone marrow (BM)-MSCs deteriorates as the cells age along with cell passaging. Recently, it has been reported that MSCs can be generated from induced pluripotent stem cells (iPSCs), which is expected to represent a new source of MSCs. However, few studies have investigated aging in iPSC-derived MSCs (iMSCs) and their functions...
November 2023: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38155615/acute-bilateral-hypotropia-and-esotropia-complex-as-first-manifestation-of-multiple-sclerosis-a-case-report
#20
Joe Senda, Ryota Hirao, Kentaro Maeda, Yoshinobu Amakusa, Tomoki Hirunagi, Masahisa Katsuno, Katsuhiro Kawaguchi
A 21-year-old Japanese woman presented with sudden eye movement disorders. An ophthalmic examination revealed bilateral hypotropia and esotropia complex. Brain magnetic resonance imaging revealed abnormal signals in the posterior and medial part of the lower pontine tegmentum (including periventricular and subcortical white matter) that were suggestive of demyelination. A cerebrospinal fluid test was positive for oligoclonal bands. She was subsequently diagnosed with multiple sclerosis and was administered intravenous methylprednisolone and oral dimethyl fumarate, with complete recovery from hypotropia and esotropia after two months...
November 2023: Nagoya Journal of Medical Science
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