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Ultrasound in Medicine & Biology

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https://www.readbyqxmd.com/read/28781149/ultrasound-improves-the-delivery-and-therapeutic-effect-of%C3%A2-nanoparticle-stabilized-microbubbles-in-breast-cancer%C3%A2-xenografts
#1
Sofie Snipstad, Sigrid Berg, Ýrr Mørch, Astrid Bjørkøy, Einar Sulheim, Rune Hansen, Ingeborg Grimstad, Annemieke van Wamel, Astri F Maaland, Sverre H Torp, Catharina de Lange Davies
Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various biological barriers and uneven tumor perfusion. We investigated a unique multifunctional drug delivery system consisting of microbubbles stabilized by polymeric nanoparticles (NPMBs), enabling ultrasound-mediated drug delivery. The aim was to examine mechanisms of ultrasound-mediated delivery and to determine if increased tumor uptake had a therapeutic benefit...
August 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28779958/efficacy-of-indocyanine-green-mediated-sonodynamic-therapy-on-rheumatoid-arthritis-fibroblast-like-synoviocytes
#2
Qin Tang, Shufang Chang, Zhonghua Tian, Jiangchuan Sun, Lan Hao, Zhigang Wang, Shenyin Zhu
Sonodynamic therapy (SDT) has become a new therapeutic method because of its activation of certain sensitizers by ultrasound. Some studies have reported that indocyanine green (ICG) has the characteristics of a sonosensitizer and favorable fluorescence imaging in synovitis of early inflammatory arthritis. In this study, we aimed to investigate the cytotoxic effect of ICG-mediated SDT on MH7A cells in vitro and the potential mechanisms involved. ICG was found to be taken up mainly in cytoplasm, with maximal uptake in 4 h...
August 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28779957/toward-a-standardization-of-ultrasound-scanners-for-dynamic-contrast-enhanced-ultrasonography-methodology-and-phantoms
#3
Stéphanie Pitre-Champagnat, Bénédicte Coiffier, Laurène Jourdain, Baya Benatsou, Ingrid Leguerney, Nathalie Lassau
The standardization of ultrasound scanners for dynamic contrast-enhanced ultrasonography (DCE-US) is mandatory for evaluation of clinical multicenter studies. We propose a robust method using a phantom for measuring the variation of the harmonic signal intensity obtained from the area under the time-intensity curve versus various contrast-agent concentrations. The slope of this measured curve is the calibration parameter. We tested our method on two devices from the same manufacturer (AplioXV and Aplio500, Toshiba, Tokyo, Japan) using the same settings as defined for a French multicenter study...
August 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28779956/ultrasound-imaging-of-the-renal-parenchyma-of-premature-neonates-for-the-assessment-of-renal-growth-and-glomerulomegaly
#4
Sonja Brennan, Yogavijayan Kandasamy
Evidence is increasingly showing that prematurity results in chronic kidney disease. We hypothesized that we could use ultrasound imaging to measure and monitor the growth of the renal parenchyma in premature neonates. We conducted a prospective, case-control study to compare renal parenchymal growth between neonates born prematurely and term neonates. The study patients underwent ultrasound assessment at 32 wk postmenstrual age (PMA) and 37 wk PMA. Term neonates (gestation >37 completed wk) admitted to the neonatal unit with minor neonatal conditions were recruited into the control group...
August 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28779955/fluid-resuscitation-in-septic-patients-improves-systolic-but-not-diastolic-middle-cerebral-artery-flow-velocity
#5
Annika A de Goede, Bert G Loef, Auke C Reidinga, Arjen Schaafsma
To investigate the effects of fluid resuscitation on cerebral hemodynamics in sepsis, the following set of transcranial Doppler (TCD) parameters was used: maximal change in flow velocity (FV) during stroke onset (acc), maximal FV during first (sys1) or second (sys2) phase of systole and mean diastolic FV (dias@560). We aim to evaluate changes in cerebral hemodynamics that result from (i) sepsis and (ii) adequate fluid resuscitation in critically ill septic patients. In the majority of 16 septic patients sys2 was initially absent but reappeared during the period of fluid resuscitation; whereas sys2 absence was never seen in healthy controls...
August 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28778420/reproducibility-and-angle-independence-of-electromechanical-wave-imaging-for-the-measurement-of-electromechanical-activation-during-sinus-rhythm-in-healthy-humans
#6
Lea Melki, Alexandre Costet, Elisa E Konofagou
Electromechanical wave imaging (EWI) is an ultrasound-based technique that can non-invasively map the transmural electromechanical activation in all four cardiac chambers in vivo. The objective of this study was to determine the reproducibility and angle independence of EWI for the assessment of electromechanical activation during normal sinus rhythm (NSR) in healthy humans. Acquisitions were performed transthoracically at 2000 frames/s on seven healthy human hearts in parasternal long-axis, apical four- and two-chamber views...
August 1, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28764967/ultrasound-imaging-of-muscle-contraction-of-the-tibialis-anterior-in-patients-with-facioscapulohumeral-dystrophy
#7
Kaj Gijsbertse, Rianne Goselink, Saskia Lassche, Maartje Nillesen, André Sprengers, Nico Verdonschot, Nens van Alfen, Chris de Korte
A need exists for biomarkers to diagnose, quantify and longitudinally follow facioscapulohumeral muscular dystrophy (FSHD) and many other neuromuscular disorders. Furthermore, the pathophysiological mechanisms leading to muscle weakness in most neuromuscular disorders are not completely understood. Dynamic ultrasound imaging (B-mode image sequences) in combination with speckle tracking is an easy, applicable and patient-friendly imaging tool to visualize and quantify muscle deformation. This dynamic information provides insight in the pathophysiological mechanisms and may help to distinguish the various stages of diseased muscle in FSHD...
July 29, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28760576/performances-and-limitations-of-several-ultrasound-based-elastography-techniques-a-phantom-study
#8
Stéphanie Franchi-Abella, Caroline Elie, Jean-Michel Correas
The objective of this study is to assess strain and shear wave (SW) elastography performance in terms of accuracy by performing in vitro measurements on a calibrated elastography phantom. Acquisitions were done on a phantom containing 4 inclusions (12-74 kPa) embedded in a homogeneous background material (30 kPa). We performed qualitative assessment on elastograms, semiquantitative assessment with strain or elasticity ratios between each inclusion and the background and quantitative evaluation with SW acquisitions...
July 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28756901/respiratory-variation-in-femoral-vein-diameter-has-moderate-accuracy-as-a-marker-of-fluid-responsivity-in-mechanically-ventilated-septic-shock-patients
#9
Wagner Luis Nedel, Daniele Moraes Simas, Luiz Gustavo Marin, Vinicius Daudt Morais, Gilberto Friedman
Ultrasound (US) is considered the first step in evaluation of patients with shock; respiratory variation of the inferior vena cava (inferior vena cava collapsibility [IVCc]) is an important measurement in this scenario that can be impaired by patient condition or technical skills. The main objective of this study was to evaluate if respiratory variation of the femoral vein (femoral vein collapsibility [FVc]), which is easier to visualize, can adequately predict fluid responsiveness in septic shock patients...
July 27, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28756900/evaluation-of-early-kidney-damage-caused-by-brain-death-using-real-time-ultrasound-elastography-in-a-bama-pig-model
#10
Ying Tang, Jingwen Zhao, Dongyang Liu, Ningning Niu, Huimin Yu
The aim of this study was to investigate the value of real-time tissue elastography (RTE) in the evaluation of early graft damage resulting from brain death. We performed RTE before and 0, 3, 6 and 9 h after brain death in a Bama pig model. Eleven RTE parameters were compared among time groups, and their correlations with electron microscopic findings were analyzed. Receiver operating characteristic curve analysis was used to find the RTE parameter cutoff values. The mean relative strain value within the region of interest (MEAN), standard deviation of the relative strain value within the region of interest (SD), percentage area of low strain within the region of interest (%AREA), complexity of low-strain area within the region of interest (COMP), kurtosis (KURT), skewness (SKEW), contrast (CONT) and entropy (ENT) and inverse difference moment (IDM) differed statistically significantly between groups (p < 0...
July 27, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28755792/quantifying-image-quality-improvement-using-elevated-acoustic-output-in-b-mode-harmonic-imaging
#11
Yufeng Deng, Mark L Palmeri, Ned C Rouze, Gregg E Trahey, Clare M Haystead, Kathryn R Nightingale
Tissue harmonic imaging has been widely used in abdominal imaging because of its significant reduction in acoustic noise compared with fundamental imaging. However, tissue harmonic imaging can be limited by both signal-to-noise ratio and penetration depth during clinical imaging, resulting in decreased diagnostic utility. A logical approach would be to increase the source pressure, but the in situ pressures used in diagnostic ultrasound are subject to a de facto upper limit based on the U.S. Food and Drug Administration guideline for the mechanical index (<1...
July 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28755791/histology-based-assessment-of-sonazoid-enhanced-ultrasonography-for-the-diagnosis-of-liver-metastasis
#12
Kazufumi Kobayashi, Hitoshi Maruyama, Soichiro Kiyono, Osamu Yokosuka, Masayuki Ohtsuka, Masaru Miyazaki, Jun Matsushima, Takashi Kishimoto, Yukio Nakatani
This retrospective study aimed to assess the diagnostic performance of contrast-enhanced ultrasound with Sonazoid (S-CEUS) for liver metastasis. We enrolled in this study 98 patients with 148 histologically proven liver lesions, with 121 metastases and 27 non-metastases. The S-CEUS technique showed sensitivity in 95.0% (115 of 121), specificity in 44.4% (12 of 27) and accuracy in 85.8% (127 of 148) for the diagnosis of metastasis. Higher body mass index had a negative influence on the positive predictive value and accuracy, and a greater depth of the lesion had a negative influence on the accuracy...
July 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28755790/correlation-between-disease-activity-and-endorectal-ultrasound-findings-of-chronic-radiation-proctitis
#13
Fei Cao, Teng-Hui Ma, Guang-Jian Liu, Yan-Lin Wen, Huai-Ming Wang, Ying-Yi Kuang, Si Qin, Xiao-Yin Liu, Bin-Jie Huang, Lei Wang
The aim of this study was to summarize the imaging features of chronic radiation proctitis (CRP) on endorectal ultrasound (ERUS) and investigate the value of ERUS in the evaluation of disease activity. 40 CRP patients and 30 control patients were investigated by ERUS. Rectal wall thickness and layers, ulcers and rectovaginal fistulas were evaluated by B-mode ultrasound. Power Doppler imaging was used to evaluate the vascularity of the rectal wall using a semiquantitative score. Disease activity was calculated according to the National Cancer Institute Common Terminology Criteria for Adverse Events 4...
July 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28755789/minimally-complex-renal-cysts-outcomes-and-ultrasound-evaluation-compared-with-contrast-enhanced-cross-sectional-imaging-bosniak-classification
#14
Marilia Henrique Destefani, Jorge Elias, Annelise Manzano Serra Negra Trazzi, Plinio Prizon Kajiwara, Aila Ferreira de Menezes, Rodolfo Borges Dos Reis, Valdair Francisco Muglia
We correlated contrast-enhanced cross-sectional imaging and outcomes to assess the reproducibility of ultrasonographic criteria for renal minimally complex (MC) cysts. From 2003 to 2015, 143 cysts were described as complex or MC by ultrasound (US). After exclusions, 98 US studies were retrospectively evaluated and compared with computed tomography (CT)/magnetic resonance imaging (MRI). At sonography, 51 were MC cysts and 47 were complexes according to two independent observers. Inter-observer agreement for US was 0...
July 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28754497/ultrasonography-improves-glycemic-control-by-detecting-insulin-derived-localized-amyloidosis
#15
Minoru Kikuchi, Naoki Hirokawa, Seiya Hagiwara, Hidetaka Nakayama, Shinji Taneda, Naoki Manda, Kouichi Sakata
We examined the feasibility of ultrasound diagnosis of insulin-derived localized amyloidosis (IDLA). In addition to ultrasound detectability and findings, the insulin absorption rate, insulin dosage and hemoglobin A1c (HbA1c) levels before and after shifting the insulin injection site were investigated for 22 cases of IDLA. The detectability of IDLA on ultrasound was 100%; 59.1% was palpable lumps and 40.9% was not palpable. The palpable type had lower echo intensity and were harder than the non-palpable type...
July 25, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28750944/vector-and-doppler-ultrasound-velocities-evaluated-in-a-flow-phantom-and-the-femoropopliteal-vein
#16
Thor Bechsgaard, Kristoffer Lindskov Hansen, Andreas Hjelm Brandt, Simon Holbek, Julie Lyng Forman, Charlotte Strandberg, Lars Lönn, Niels Bækgaard, Jørgen Arendt Jensen, Michael Bachmann Nielsen
Ultrasound is used for evaluating the veins of the lower extremities. Operator and angle dependency limit spectral Doppler ultrasound (SDUS). The aim of the study was to compare peak velocity measurements in a flow phantom and the femoropopliteal vein of 20 volunteers with the angle-independent vector velocity technique vector flow imaging (VFI) and SDUS. In the flow phantom, VFI underestimated velocity (p = 0.01), with a lower accuracy of 5.5% (p = 0.01) and with no difference in precision, that is, error factor, compared with SDUS (VFI: 1...
July 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28750943/effect-of-preterm-birth-on-echogenicity-in-basal-ganglia
#17
Robbin de Goederen, Marlou M A Raets, Ginette M Ecury-Goossen, Rogier C J de Jonge, Luca A Ramenghi, Irene V Koning, Paul Govaert, Jeroen Dudink
In this study, the influence of prematurity on echogenicity of deep gray matter at 30-wk corrected age was assessed using ultrasound measurements. In an observational cohort study, ultrasound scans of 224 extremely preterm infants were prospectively collected. Gray values were assessed in putamen and globus pallidus. Intra- and inter-observer reliability was analyzed and showed excellent agreement. The globus pallidus to putamen ratio was significantly related to gestational age at birth, adjusted regression coefficient in points per wk: 1...
July 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28743376/spatio-temporal-image-correlation-stic-estimation-of-heart-rate-using-stic-compared-with-2-d-pulsed-wave-doppler-in-a-flow-phantom
#18
LETTER
Gordon N Stevenson, Reza Keshavarzi, Ana Gomes de Melo Tavares Ferreira, Tracie Barber, Alec W Welsh
No abstract text is available yet for this article.
July 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28743375/a-model-based-prediction-of-the-probability-of%C3%A2-hepatocellular%C3%A2-adenoma-and-focal-nodular-hyperplasia%C3%A2-based%C3%A2-on-characteristics-on-contrast-enhanced%C3%A2-ultrasound
#19
Pavel Taimr, Mirelle E E Bröker, Roy S Dwarkasing, Bettina E Hansen, Robert J de Knegt, Robert A De Man, Jan N M IJzermans
Contrast-enhanced ultrasound (CEUS) is an emerging imaging technique that is increasingly used to diagnose liver lesions. It is of the utmost importance to differentiate between the two most common solid focal liver lesions (i.e., hepatocellular adenoma [HCA] and focal nodular hyperplasia [FNH]), because their management and follow-up differ greatly. The main objective of this study was to determine how frequently the specific CEUS features of HCA and FNH are visible on CEUS and to define their predictive value for discrimination between HCA and FNH...
July 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28739379/ultrasound-induced-bubble-clusters-in-tissue-mimicking-agar%C3%A2-phantoms
#20
Pooya Movahed, Wayne Kreider, Adam D Maxwell, Barbrina Dunmire, Jonathan B Freund
Therapeutic ultrasound can drive bubble activity that damages soft tissues. To study the potential mechanisms of such injury, transparent agar tissue-mimicking phantoms were subjected to multiple pressure wave bursts of the kind being considered specifically for burst wave lithotripsy. A high-speed camera recorded bubble activity during each pulse. Various agar concentrations were used to alter the phantom's mechanical properties, especially its stiffness, which was varied by a factor of 3.5. However, the maximum observed bubble radius was insensitive to stiffness...
July 21, 2017: Ultrasound in Medicine & Biology
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