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Ultrasound in Medicine & Biology

Gemma Olivé, Thais Agut, Carlos Mario Echeverría-Palacio, Gemma Arca, Alfredo García-Alix
Magnetic resonance imaging is the gold standard technique in establishing the diagnosis of neonatal arterial ischemic stroke (NAIS). The diagnostic value of cranial ultrasound scanning in this clinical context is controversial. We aimed to assess the current sensitivity of the cranial ultrasound scan (CUS) in detecting NAIS, as this issue has not been well described in the literature. Newborns with NAIS diagnosed by magnetic resonance imaging between 2010 and 2016 were included. All CUSs were blindly analyzed retrospectively by a neonatologist expert in neuroimaging and compared with the findings of non-expert evaluators recorded on medical charts immediately after performing the evaluation...
January 11, 2019: Ultrasound in Medicine & Biology
Louise Marais, Mathieu Pernot, Hakim Khettab, Mickael Tanter, Emmanuel Messas, Mustapha Zidi, Stéphane Laurent, Pierre Boutouyrie
Shear wave elastography and ultrafast imaging of the carotid artery pulse wave were performed in 27 normotensive participants and 29 age- and sex-matched patients with essential hypertension, and compared with reference techniques: carotid-femoral pulse wave velocity (cfPWV) determined via arterial tonometry and carotid stiffness (carPWV) determined via echotracking. Shear wave speed in the carotid anterior (a-SWS) and posterior (p-SWS) walls were assessed throughout the cardiac cycle. Ultrafast PWV was measured in early systole (ufPWV-FW) and in end-systole (dicrotic notch, ufPWV-DN)...
January 11, 2019: Ultrasound in Medicine & Biology
Mark T Burgess, Tyrone M Porter
Acoustic cavitation can be used to temporarily disrupt cell membranes for intracellular delivery of large biomolecules. Termed sonoporation, the ability of this technique for efficient intracellular delivery (i.e., >50% of initial cell population showing uptake) while maintaining cell viability (i.e., >50% of initial cell population viable) has proven to be very difficult. Here, we report that phase-shift nanoemulsions (PSNEs) function as inertial cavitation nuclei for improvement of sonoporation efficiency...
January 11, 2019: Ultrasound in Medicine & Biology
Yuan Zhang, Ying Zheng, Xuesong Yang, Xuqing Liu, Haiying Zhang, Xiaoluan Xu, Fankun Meng
The purpose of this study was to compare acoustic structure quantification (ASQ) with transient elastography for staging liver fibrosis. One hundred eighty-two patients with chronic hepatitis B and without moderate to severe hepatic steatosis scheduled for liver biopsy underwent ASQ and transient elastography examinations. All ASQ parameters, including total mode, total average, red mode, red average, red standard deviation, blue mode, blue average, blue standard deviation and focal disturbance (FD) ratio and liver stiffness obtained via transient elastography were found to correlate with fibrosis stage (Spearman's r = 0...
January 10, 2019: Ultrasound in Medicine & Biology
Massimo Salvi, Cristina Caresio, Kristen M Meiburger, Bruno De Santi, Filippo Molinari, Marco Alessandro Minetto
Ultrasonography allows non-invasive and real time-measurement of the visible cross-sectional area (CSA) of muscles, which is a clinically relevant descriptor of muscle size. The aim of this study was to develop and validate a fully automatic method called transverse muscle ultrasound analysis (TRAMA) for segmentation of the muscle in B-mode transverse ultrasound images and measurement of muscle CSA. TRAMA was tested on a database of 200 ultrasound images of the rectus femoris, vastus lateralis, tibialis anterior and medial gastrocnemius muscles...
January 9, 2019: Ultrasound in Medicine & Biology
Sara Keller, Matthew Bruce, Michalakis A Averkiou
Ultrasound-mediated drug delivery using the mechanical action of oscillating and/or collapsing microbubbles has been studied on many different experimental platforms, both in vitro and in vivo; however, the mechanisms remain to be elucidated. Many groups use sterile, enclosed chambers, such as Opticells and Clinicells, to optimize acoustic parameters in vitro needed for effective drug delivery in vivo, as well as for mechanistic investigation of sonoporation or the use of sound to permeate cell membranes. In these containers, cell monolayers are seeded on one side, and the remainder of the volume is filled with a solution containing microbubbles and a model drug...
January 9, 2019: Ultrasound in Medicine & Biology
Lei Zhang, Jinfeng Xu, Huaiyu Wu, Weiyu Liang, Xiuqin Ye, Hongtian Tian, Fajin Dong
The aim of the study described here was to screen breast lesions using either or both shear modulus (G) and its 1-mm shell (S) in sound touch elastography through a retrospective study of 209 consecutive women with breast lesions. The ability of G and S data to differentiate between malignant and benign lesions was evaluated using the receiver operating characteristic (ROC) curve. The optimal cutoff point, sensitivity, specificity, positive likelihood ratio (LR+) and negative likelihood ratio (LR-) were calculated...
January 8, 2019: Ultrasound in Medicine & Biology
Katsuji Inoue, Toshihiko Asanuma, Kasumi Masuda, Daisuke Sakurai, Takafumi Okura, Jitsuo Higaki, Satoshi Nakatani
Left atrial (LA) work can be measured through speckle tracking echocardiography by calculating LA pressure-strain loop area, which includes two distinct phases of active contraction/relaxation (A-work) and passive dilation/emptying (V-work). Echocardiographic and hemodynamic data were acquired at baseline and during occlusions of left anterior descending (LAD: n = 7) and left circumflex (LCx: n = 9) coronary arteries in dogs. Left ventricular (LV) circumferential strain was decreased and mean LA pressure was increased in both occlusions...
January 4, 2019: Ultrasound in Medicine & Biology
Xinhuan Zhou, Virginie Papadopoulou, Chee Hau Leow, Peter Vincent, Meng-Xing Tang
Quantification of 3-D intravascular flow is valuable for studying arterial wall diseases but currently there is a lack of effective clinical tools for this purpose. Divergence-free interpolation (DFI) using radial basis function (RBF) is an emerging approach for full-field flow reconstruction using experimental sparse flow field samples. Previous DFI reconstructs full-field flow from scattered 3-D velocity input obtained using phase-contrast magnetic resonance imaging with low temporal resolution. In this study, a new DFI algorithm is proposed to reconstruct full-field flow from scattered 2-D in-plane velocity vectors obtained using ultrafast contrast-enhanced ultrasound (>1000 fps) and particle imaging velocimetry...
January 4, 2019: Ultrasound in Medicine & Biology
Anyu Tao, Guangzhi Chen, Youbin Deng, Renfan Xu
A systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of substantia nigra hyper-echogenicity by transcranial sonography (TCS) for the diagnosis of Parkinson's disease (PD). PubMed, Embase and the Cochrane Library were electronically searched from inception to June 2018 for all relevant studies. The methodological quality of each study was evaluated by two independent reviewers, who used the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Articles reporting information sufficient to calculate the sensitivity and specificity of TCS to diagnose PD were included...
January 3, 2019: Ultrasound in Medicine & Biology
Béatrice Skiöld, Boubou Hallberg, Brigitte Vollmer, Ulrika Ådén, Mats Blennow, Sandra Horsch
The role of term-equivalent-age (TEA) cranial ultrasound (cUS) in predicting outcome in preterm infants is increasingly being recognized. However, a detailed quantitative scoring system that allows comparison of groups and comparison with TEA magnetic resonance imaging (MRI) scoring systems is lacking. Eighty-four extremely preterm infants underwent cUS and MRI at TEA. Cranial US was evaluated using a novel detailed scoring system. Agreement between cUS and MRI scores was good (Spearman's ρ = 0.51, p < 0...
January 2, 2019: Ultrasound in Medicine & Biology
Miguel Caixinha, Pedro Oliveira, Inês D Aires, António Francisco Ambrósio, Ana Raquel Santiago, Mário Santos, Jaime Santos
Diabetes mellitus (DM) is a metabolic disease that affects 9% of the adult population, promoting an increase in glucose concentration that affects the corneal structure, namely, its thickness, as well as the constituents and flow of the aqueous humor. In this study, high-frequency transducers (20-MHz and 50-MHz) were used to measure and characterize changes in the corneal and aqueous humor in streptozotocin-induced type 1 diabetic rats followed over 8 weeks. Increases of 24.6 and 15.4 μm in central corneal thickness were measured with the 20-MHz and 50-MHz probes, respectively, in DM rats (p < 0...
December 31, 2018: Ultrasound in Medicine & Biology
Yan Zhou, Xiang Jing, Xiang Zhang, Jianmin Ding, Yandong Wang, Hongyu Zhou, Qin Zhang, Ying Chen, Wenjun Yue
Contrast-enhanced ultrasonography (CEUS) and gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) were compared with respect to diagnostic efficacy in the detection of small hepatocellular carcinoma. A new diagnostic strategy that combines the arterial phase of CEUS, the hepatobiliary phase of EOB-MRI and diffusion-weighted MR imaging (DWI) is described. One hundred sixteen nodules were enrolled to validate the performance of the strategy. For lesions ≤20 mm in size, the areas under the receiver operating characteristic curves (Az) of CEUS and EOB-MRI were 0...
December 31, 2018: Ultrasound in Medicine & Biology
Laurence Rocher, Aline Criton, Jean-Luc Gennisson, Maud Creze, Laurence Albiges, Sophie Ferlicot, Marie-France Bellin, Vincent Izard, Jean-Michel Correas
We prospectively evaluated the performance of combined shear wave elastography (SWE) and conventional ultrasound (US) for the characterization of 89 testicular focal masses. Testes were evaluated with B-mode, color Doppler and SWE measurements, locating a region of interest on the normal and pathologic parenchyma. Thirty-seven malignant tumors (MTs), 12 burned out tumors (BOTs), 28 Leydig cell tumors (LCTs), 2 dermoid cysts and other benign lesions were included. MTs + BOTs exhibited more microliths and macrocalcifications compared with benign lesions (p < 10-4 )...
December 29, 2018: Ultrasound in Medicine & Biology
Marcelino Ferri, José M Bravo, Javier Redondo, Juan V Sánchez-Pérez
The correction of transcranial focused ultrasound aberrations is a relevant issue for enhancing various non-invasive medical treatments. The emission through multi-element phased arrays has been the most widely accepted method to improve focusing in recent years; however, the number and size of transducers represent a bottleneck that limits the focusing accuracy of the technique. To overcome this limitation, a new disruptive technology, based on 3-D-printed acoustic lenses, has recently been proposed. As the submillimeter precision of the latest generation of 3-D printers has been proven to overcome the spatial limitations of phased arrays, a new challenge is to improve the accuracy of the numerical simulations required to design this type of ultrasound lens...
December 29, 2018: Ultrasound in Medicine & Biology
Jingjing Xia, Yi Yang, Chenwenbao Hu, Rui Meng, Qiuju Jiang, Rong Liu, Yanyan Yu, Zonghai Sheng, Fei Yan, Lijuan Zhang, Zhifeng Shi, Hairong Zheng, Weibao Qiu
Precisely evaluating the characteristics of a glioma tumor in vivo is challenging when performing surgical resection clinically. The infiltration characteristics of a tumor make precise resection difficult because of uncertainties about the surrounding vasculature and the relationships with functional structures. Magnetic resonance imaging is routinely used to distinguish the area of a glioma, but it cannot resolve details of the vascular network around or inside the tumor. Ultrasound imaging is a real-time imaging modality that has been applied clinically in intra-operative surgery, and the sensitivity of flow measurements in the brain is improved by ultrafast plane wave imaging...
December 28, 2018: Ultrasound in Medicine & Biology
Xiaoming Zhang, Boran Zhou, Brian Bartholmai, Sanjay Kalra, Thomas Osborn
Lung ultrasound surface wave elastography (LUSWE) is a novel non-invasive technique for measuring superficial lung tissue stiffness. The purpose of the study described here was to develop LUSWE for assessment of progression in patients with interstitial lung disease (ILD). In this study, LUSWE was used to measure changes in lung surface wave speeds at 100, 150 and 200 Hz through six intercostal lung spaces for 52 patients with ILD. The mean age was 63.1 ± 12.0 y (range: 20-85, 23 male and 29 female). The follow-up interval was 9...
December 28, 2018: Ultrasound in Medicine & Biology
Fangfang Wang, Tiemei Shi, Chang Su
This study was aimed at assessing the effects of urokinase (UK) in combination with ultrasound and microbubbles in in vitro and in vivo thrombolytic therapy for the treatment of deep vein thrombosis (DVT). Thrombi with formation times of 1, 3, 7, 14 and 21 d were used for thrombolysis. Forty-five adult mongrel dogs were used to evaluate thrombosis in vivo. Both in vitro and in vivo analyses revealed that UK + microbubbles had the best effect among the combinations. Thrombolysis <7 d was more effective at a thrombolysis rate of about 50%, but the thrombolytic effect of thrombi >7 d was poor at thrombolysis rates <30%...
December 27, 2018: Ultrasound in Medicine & Biology
Lauren Bohner, Daniel Habor, Felix Gremse, Pedro Tortamano, Stefan Wolfart, Juliana Marotti
The purpose of this study was to assess the accuracy of high-frequency ultrasound (US) in the measurement of peri-implant bone defects in comparison with cone-beam computed tomography (CBCT) and micro-computed tomography (µCT). Bone defects were mechanically created around dental implants inserted into porcine ribs (n = 10). The bone samples were scanned by CBCT, µCT and US. Linear dimensions of the peri-implant defects were determined for supra-alveolar component, intra-bony component and width. The accuracy of measurements was evaluated with repeated-measures analysis of variance and the intra-class correlation coefficient at p ≤ 0...
December 26, 2018: Ultrasound in Medicine & Biology
Ourania Dagadaki, Konstantinos Birbas, Theodoros Mariolis, George Baltopoulos, Pavlos Myrianthefs
The utility of periodic sonographic assessment and monitoring for early diagnosis of deep vein thrombosis (DVT) in patients hospitalized in intensive care units (ICUs) was investigated. Of 314 patients hospitalized in an ICU over a 24-mo period, 248 were examined. The first examination of the patients was carried out within the first 48 h of ICU admission, and weekly examination followed until discharge. Peripheral veins were examined according to the general principles of the ultrasound study using the compression test in B-mode imaging (image to gray scale)...
December 21, 2018: Ultrasound in Medicine & Biology
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