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Ultrasound in Medicine & Biology

Xi Xiang, Feng Yan, Yujia Yang, Yuanjiao Tang, Liyun Wang, Jia Zeng, Li Qiu
The goal of this study was to investigate the reliability and feasibility of shear wave elastography by assessing the elasticity of the healthy skin of 40 volunteers. Young's moduli for bilateral fingers, forearms, anterior chest (sternum), and anterior abdomen were determined with both transverse and longitudinal sectional measurements. Reliability of measurements was evaluated using intra- and inter-class correlation coefficients with two observers. Our results revealed that the elastic modulus values of the skin between symmetric parts of fingers and forearms did not statistically different...
December 2, 2016: Ultrasound in Medicine & Biology
Guo-Yang Li, Qiong He, Lin Jia, Ping He, Jianwen Luo, Yanping Cao
Many cardiovascular diseases can alter arterial stiffness; therefore, measurement of arterial wall stiffness can provide valuable information for both diagnosis of such diseases in the clinic and evaluation of the effectiveness of relevant drugs. However, quantitative assessment of the in vivo elastic properties of arterial walls in a non-invasive manner remains a great challenge. In this study, we found that the elastic modulus of the arterial wall can be extracted from the dispersion curve of the guided axial wave (GAW) measured using the ultrasound elastography method...
November 28, 2016: Ultrasound in Medicine & Biology
Siyuan Zhang, Yuqiang Han, Xingguang Zhu, Shaoqiang Shang, Guojing Huang, Lei Zhang, Gang Niu, Supin Wang, Xijing He, Mingxi Wan
The feasibility of using ultrasonic Nakagami imaging to evaluate thermal lesions induced by microwave ablation (MWA) in ex vivo porcine liver was explored. Dynamic changes in echo amplitudes and Nakagami parameters in the region of the MWA-induced thermal lesion, as well as the contrast-to-noise ratio (CNR) between the MWA-induced thermal lesion and the surrounding normal tissue, were calculated simultaneously during the MWA procedure. After MWA exposure, a bright hyper-echoic region appeared in ultrasonic B-mode and Nakagami parameter images as an indicator of the thermal lesion...
November 25, 2016: Ultrasound in Medicine & Biology
Chundong Zhang, Xin Wang, Jie Tang
This study aimed to investigate the feasibility of evaluating acute kidney injury (AKI) using contrast ultrasonography in a rabbit model of crush syndrome. Sixty-four New Zealand white rabbits were anesthetized and the left hind limb was wrapped and compressed for 4 h with a sphygmomanometer. Contrast ultrasonography of the left kidney using microbubbles as the contrast medium was performed. The serum levels of blood urea nitrogen (BUN), creatine (Cr), creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in comparison to before the compression...
November 22, 2016: Ultrasound in Medicine & Biology
Paul Störchle, Wolfram Müller, Marietta Sengeis, Helmut Ahammer, Alfred Fürhapter-Rieger, Norbert Bachl, Sonja Lackner, Sabrina Mörkl, Sandra Holasek
A recently standardized ultrasound technique for measuring subcutaneous adipose tissue (SAT) was applied to normal-weight, overweight and obese persons. Eight measurement sites were used: upper abdomen, lower abdomen, erector spinae, distal triceps, brachioradialis, lateral thigh, front thigh and medial calf. Fat compression was avoided. Fat patterning in 38 participants (body mass index: 18.6-40.3 kgm(-2); SAT thickness sums from eight sites: 12-245 mm) was evaluated using a software specifically designed for semi-automatic multiple thickness measurements in SAT (sound speed: 1450 m/s) that also quantifies embedded fibrous structures...
November 17, 2016: Ultrasound in Medicine & Biology
Randy L King, Yunbo Liu, Gerald R Harris
The soft tissue thermal index defined in the Output Display Standard is not applicable to eye exposures because of unique eye properties such as high ultrasound absorption in the lens and orbital fat. To address this potential safety issue, the U.S. Food and Drug Administration has recommended a maximum exposure level for ophthalmic exams of 50 mW/cm(2) (derated spatial-peak temporal-average intensity, ISPTA.3) based on a model of ultrasound propagation in the eye. To gain a better understanding of actual temperature rise as a function of ISPTA...
November 3, 2016: Ultrasound in Medicine & Biology
Xue-Jun Ni, Xiao-Dong Wang, Ya-Hong Zhao, Hua-Lin Sun, Yu-Ming Hu, Jian Yao, Yi Wang
Low-intensity ultrasound (LIU) can improve nerve regeneration and functional recovery after peripheral nerve crush injury, but the underlying mechanism is not clear. The objective of this study was to examine the effects of LIU on rat sciatic crush injury and to investigate a possible molecular mechanism. Adult male Sprague-Dawley rats underwent left sciatic nerve crush surgery and were then randomized into two groups: a treatment group that received LIU every other d, and a control group that received sham exposure...
November 2, 2016: Ultrasound in Medicine & Biology
Gholam Reza Raissi, Fatemeh Ghazaei, Bijan Forogh, Seyed Pezhman Madani, Abbas Daghaghzadeh, Tannaz Ahadi
This study examined the effectiveness of radial extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome (CTS). Forty patients with mild to moderate CTS were allocated to two groups: (i) shock wave + wrist splint and (ii) wrist splint. Patients used wrist splints followed by three sessions of low-energy shock wave therapy in the intervention group and wrist splints alone in the other group. The QuickDASH Questionnaire, visual analogue scale and nerve conduction studies were used to evaluate the patients before the study and at 3, 8 and 12 wk after the start of the treatment...
November 1, 2016: Ultrasound in Medicine & Biology
Che-Yu Lin, Pei-Yu Chen, Yio-Wha Shau, Chung-Li Wang
Supersonic shear wave elastography is a novel ultrasound technology that allows objective evaluation of soft tissue stiffness. The purpose of this study is to report an artifact in supersonic shear wave elastography that may strongly affect the accuracy and quality of the measurement of soft tissue stiffness, and to step-by-step describe how the artifact was found and how it was verified by a series of experiments under different conditions. There were a total of three longitudinal band-like artifacts, 1.3 cm apart from each other on the entire image along the length of the SuperLinear SL15-4 transducer surface, with the middle one at the center of the image...
October 25, 2016: Ultrasound in Medicine & Biology
Nathan McDannold, Yongzhi Zhang, Natalia Vykhodtseva
Numerous researchers are investigating the use of microbubble-enhanced ultrasound to disrupt the blood-brain barrier (BBB) and deliver drugs to the brain. This study investigated the impact of using oxygen as a carrier gas for anesthesia on microbubble activity and BBB disruption. Targets in mice were sonicated in combination with administration of Optison microbubbles (100 μL/kg) under isoflurane anesthesia with either oxygen or medical air. A 690-kHz focused ultrasound transducer applied 10-ms bursts at peak pressure amplitudes of 0...
October 24, 2016: Ultrasound in Medicine & Biology
Roberta Cirincione, Federica Maria Di Maggio, Giusi Irma Forte, Luigi Minafra, Valentina Bravatà, Laura Castiglia, Vincenzo Cavalieri, Giovanni Borasi, Giorgio Russo, Domenico Lio, Cristina Messa, Maria Carla Gilardi, Francesco Paolo Cammarata
In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity...
October 22, 2016: Ultrasound in Medicine & Biology
Doo Kyoung Kang, Yongsik Jung, Sehwan Han, Ji Young Kim, Tae Hee Kim
This study evaluated the usefulness of magnetic resonance (MR)-navigated ultrasound (US) for evaluation of magnetic resonance imaging (MRI)-detected lesions not visible on second-look US and analyzed differences in lesion-to-nipple distance between supine and prone positions. Of the 831 consecutive patients who were diagnosed with breast cancer and examined with breast MRI from June 2013 to September 2015, 40 lesions in 37 patients who underwent MR-navigated US for MRI-detected lesions that were not visible on second-look US were included...
October 22, 2016: Ultrasound in Medicine & Biology
Molly A B Blank, James F Antaki
In this systematic review and meta-analysis, we report measured elasticities of benign and malignant breast pathologies from shear wave elastography (SWE), quantitatively confirm the effect of the selected region of interest (ROI) on these measures and test the hypothesis that a metric of heterogeneity based on the mean and maximum elasticity can improve specificity of diagnosis. The elasticities of benign, malignant and specific pathologic states are reported from 22 publications encompassing 2989 patients, identified from a structured search of the literature from May to September 2015...
October 14, 2016: Ultrasound in Medicine & Biology
Emmelie Stock, Katrien Vanderperren, Hendrik Haers, Luc Duchateau, Myriam Hesta, Jimmy H Saunders
Contrast-enhanced ultrasound is a valuable and safe technique for the evaluation of organ perfusion. Repeated injections of ultrasound contrast agent are often administered during the same imaging session. However, it remains unclear if quantitative differences are present between the consecutive microbubble injections. Therefore, the first and second injection of contrast agent for the left renal cortex, renal medulla and the splenic parenchyma in healthy cats were compared. A lower peak intensity and area under the curve were observed for the first injection of contrast agent in the feline kidney, both for the renal cortex and medulla, and spleen...
October 13, 2016: Ultrasound in Medicine & Biology
Paul S Sheeran, Kimoon Yoo, Ross Williams, Melissa Yin, F Stuart Foster, Peter N Burns
Phase-shift perfluorocarbon droplets have been investigated for over 20 years as pre-clinical ultrasound contrast agents with distinctive advantages in imaging and therapy. A number of formulation strategies exist, each with inherent advantages and limitations. In this note, we demonstrate a unique opportunity: that phase-shift droplets can be generated directly from commercially available microbubbles. This may facilitate pre-clinical and translational development by reducing the in-house synthesis expertise and resources required to generate high concentration droplet emulsions...
October 7, 2016: Ultrasound in Medicine & Biology
Fei Wang, Yueheng Li, Zhengyan Yang, Keke Lu, Jing Zuo, Zhi Zhou
This study investigated histopathologic changes in dental pulp after treatment with low-intensity pulsed ultrasound (LIPUS). Fifty rats were randomly divided into an experimental group (n = 25) and a blank control group (n = 25). In the experimental group, a cavity was prepared in the bilateral maxillary first molars. The upper right first molars were stimulated with LIPUS (30 mW/cm(2), 1.5 MHz) for 20 min/d. The cavities prepared in the left teeth were used as experimental controls (i.e., no LIPUS)...
January 2017: Ultrasound in Medicine & Biology
Siqing Nie, Jinhua Yu, Ping Chen, Yuanyuan Wang, Jian Qiu Zhang
Fetal nuchal translucency (NT) thickness is one of the most important parameters in prenatal screening. Locating the mid-sagittal plane is one of the key points to measure NT. In this paper, an automatic method for the sagittal plane detection using 3-D ultrasound data is proposed. To avoid unnecessary massive searching and the corresponding huge computation load, a model is proposed to turn the sagittal plane detection problem into a symmetry plane and axis searching problem. The deep belief network (DBN) and a modified circle detection method provide prior knowledge for the searching...
January 2017: Ultrasound in Medicine & Biology
James R McLaughlan, Sevan Harput, Radwa H Abou-Saleh, Sally A Peyman, Stephen Evans, Steven Freear
Therapeutic microbubbles could make an important contribution to the diagnosis and treatment of cancer. Acoustic characterisation was performed on microfluidic generated microbubble populations that either were bare or had liposomes attached. Through the use of broadband attenuation techniques (3-8 MHz), the shell stiffness was measured to be 0.72 ± 0.01 and 0.78 ± 0.05 N/m and shell friction was 0.37 ± 0.05 and 0.74 ± 0.05 × 10(-6) kg/s for bare and liposome-loaded microbubbles, respectively...
January 2017: Ultrasound in Medicine & Biology
David E Clay, Annika C Linke, Daniel J Cameron, Bobby Stojanoski, Stephen Rulisa, Aggrey Wasunna, Sandrine de Ribaupierre, Rhodri Cusack
Neuroimaging is a valuable diagnostic tool for the early detection of neonatal brain injury, but equipment and radiologic staff are expensive and unavailable to most hospitals in developing countries. We evaluated an affordable, portable ultrasound machine as a quantitative and qualitative diagnostic tool and to establish whether a novice sonographer could effectively operate the equipment and obtain clinically important information. Cranial ultrasonography was performed on term healthy, pre-term and term asphyxiated neonates in Rwandan and Kenyan hospitals...
January 2017: Ultrasound in Medicine & Biology
Belfor Antonio Galaz, Rodrigo Hernan Acevedo
Ultrasound poroelastography is an imaging modality used to characterize the temporal behavior of soft tissue that can be modeled as a solid permeated by interconnected pores filled with liquid (poroelastic medium). It could be useful in the stage classification of lymphedema. Generally, time-constant models are applied to strain images, and precision of the fitting process, computational cost and versatility in response to changes in tissues properties are crucial aspects of clinical applications. In the work described here, we performed creep experiments on poroelastic phantoms and used rheologic models to visualize the changes in viscoelastic response associated with fluid mobility...
January 2017: Ultrasound in Medicine & Biology
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