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Ultrasound in Medicine & Biology

Julian Garcia-Duitama, Boris Chayer, Damien Garcia, Yves Goussard, Guy Cloutier
Erythrocyte aggregation is a non-specific marker of acute and chronic inflammation. Although it is usual to evaluate this phenomenon from blood samples analyzed in laboratory instruments, in vivo real-time assessment of aggregation is possible with spectral ultrasound techniques. However, variable blood flow can affect the interpretation of acoustic measures. Therefore, flow standardization is required. Two techniques of flow standardization were evaluated with porcine and equine blood samples in Couette flow...
September 8, 2017: Ultrasound in Medicine & Biology
Yaoheng Yang, Zhihai Qiu, Xuandi Hou, Lei Sun
Ultrasound imaging is a common modality in clinical examination and biomedical research, but has not played a significant role in molecular imaging for lack of an appropriate contrast agent. Recently, biogenic gas vesicles (GVs), naturally formed by cyanobacteria and haloarchaea, have exhibited great potential as an ultrasound molecular imaging probe with a much smaller size (∼100 nm) and improved imaging contrast. However, the basic acoustic and biological properties of GVs remain unclear, which hinders future application...
September 7, 2017: Ultrasound in Medicine & Biology
Carolina Freitas Lins, Mittermayer Barreto Santiago
No abstract text is available yet for this article.
September 5, 2017: Ultrasound in Medicine & Biology
Matteo Piga, Alessandra Gabba, Alessandro Mathieu, Alberto Cauli
No abstract text is available yet for this article.
September 4, 2017: Ultrasound in Medicine & Biology
Maria Chiara Scali, Angela Zagatina, Iana Simova, Nadezhda Zhuravskaya, Quirino Ciampi, Marco Paterni, Mario Marzilli, Clara Carpeggiani, Eugenio Picano
Various lung ultrasound (LUS) scanning modalities have been proposed for the detection of B-lines, also referred to as ultrasound lung comets, which are an important indication of extravascular lung water at rest and after exercise stress echo (ESE). The aim of our study was to assess the lung water spatial distribution (comet map) at rest and after ESE. We performed LUS at rest and immediately after semi-supine ESE in 135 patients (45 women, 90 men; age 62 ± 12 y, resting left ventricular ejection fraction = 41 ± 13%) with known or suspected heart failure or coronary artery disease...
August 30, 2017: Ultrasound in Medicine & Biology
Brandon L Helfield, Xucai Chen, Bin Qin, Simon C Watkins, Flordeliza S Villanueva
Sonoporation is emerging as a feasible, non-viral gene delivery platform for the treatment of cardiovascular disease and cancer. Despite promising results, this approach remains less efficient than viral methods. The objective of this work is to help substantiate the merit of polymeric microbubble sonoporation as a non-viral, localized cell permeation and payload delivery strategy by taking a ground-up approach to elucidating the fundamental mechanisms at play. In this study, we apply simultaneous microscopy of polymeric microbubble sonoporation over its intrinsic biophysical timescales-with sub-microsecond resolution to examine microbubble cavitation and millisecond resolution over several minutes to examine local macromolecule uptake through enhanced endothelial cell membrane permeability-bridging over six orders of magnitude in time...
August 25, 2017: Ultrasound in Medicine & Biology
Himanshu Shekhar, Jeffrey S Rowan, Marvin M Doyley
Contrast-enhanced intra-vascular ultrasound (CE-IVUS) imaging could provide clinicians a valuable tool to assess cardiovascular risk and guide the choice of therapeutic strategies. In this technical note, we evaluated the feasibility of combining subharmonic and ultraharmonic imaging to improve the performance of CE-IVUS. Vessel phantoms perfused with phospholipid-shelled ultrasound contrast agents were visualized using subharmonic, ultraharmonic and combined CE-IVUS modes with commercial peripheral and coronary imaging catheters...
August 25, 2017: Ultrasound in Medicine & Biology
Jieyi Ye, Xiaoyan Xie, Baoxian Liu, Xiaoer Zhang, Wei Wang, Xiaowen Huang, Mingde Lu, Guangliang Huang
The objective of this study was to compare the clinical characteristics and imaging features on contrast-enhanced ultrasound (CEUS) of hepatitis B virus (HBV)-related combined hepatocellular-cholangiocarcinoma (CHC) and hepatocellular carcinoma (HCC). Thirty-one pathologically proven CHCs were included and 31 HCCs were randomly selected as controls. Elevated carbohydrate antigen (CA) 19-9 alone and simultaneous elevation of α-fetoprotein and CA19-9 were more frequent in CHC than in HCC patients (p = 0.004 and 0...
August 25, 2017: Ultrasound in Medicine & Biology
Lujing Li, Xinchuan Zhou, Xinbao Zhao, Shaoyun Hao, Jiyi Yao, Wenjing Zhong, Hui Zhi
Non-mass breast lesions on ultrasound (US) are areas without an associated mass. The purpose of this study was to evaluate whether combining B-mode US with color Doppler US and strain elastography (SE) improves US differentiation between benign and malignant non-mass breast lesions and the decision for biopsy. In this prospective study, three different radiologists analyzed the US images of 77 non-mass lesions independently and recorded Breast Imaging Reporting and Data System (BI-RADS) categories for four data sets...
August 24, 2017: Ultrasound in Medicine & Biology
Jeong Eun Lee, Kyung Sook Shin, June-Sik Cho, Sun Kyoung You, Ji Hye Min, Kyung-Hee Kim, In Sang Song, Kwang Sik Cheon
We investigated the feasibility of using ultrasound shear wave elastography point quantification (ElastPQ) for liver fibrosis staging and compared it with other non-invasive tools with respect to efficacy in liver stiffness measurement. A total of 106 patients who underwent liver stiffness measurements, using ElastPQ and biochemical investigations, before parenchymal liver biopsy or surgery were included. Among these, 51 also underwent transient elastography (TE). Correlations of ElastPQ, TE and aspartate aminotransferase-to-platelet ratio index (APRI) with histopathological findings (as the reference standard) were determined using Spearman's correlation coefficient...
August 24, 2017: Ultrasound in Medicine & Biology
Rui Xie, Tongying Xu, Jiuxin Zhu, Xiaoli Wei, Wenting Zhu, Longmin Li, Yufeng Wang, Yu Han, Jianhua Zhou, Yuxian Bai
Sonodynamic therapy (SDT) overcomes the shortcoming of photodynamic therapy in the treatment of cancer. Previous studies indicated that the glycolysis inhibitor 2-deoxyglucose (2-DG) potentiated photodynamic therapy induced tumor cell death and microbubbles (MBs) improved the SDT performance. We hypothesized that the combination of 2-DG and MBs will increase the effect of 5-aminolevulinic acid (ALA)-SDT in HepG2 liver cancer cells. When cells were treated with 5-min ALA-SDT and 2-mmol/L 2-DG, the cell survival rate decreased to 73...
August 23, 2017: Ultrasound in Medicine & Biology
Jacinta E Browne, Louise M Cannon, Ronan McDermott, Max Ryan, Andrew J Fagan
A device for the training and quantitative assessment of the competency of trainee radiologists in the technically challenging area of breast sonography was developed and evaluated. Currently, suitable commercially available devices are lacking, and there is a growing realization that the reliance on direct exposure to patients for learning may not represent best practice from either the trainees' or patients' perspective. Three devices (PI, PII and PIII) were designed to produce very realistic sonographic images of breast morphology with a range of embedded pathologies...
August 23, 2017: Ultrasound in Medicine & Biology
Se-Young Kim, Kyoung Won Kim, Sang Hyun Choi, Jae Hyun Kwon, Gi-Won Song, Heon-Ju Kwon, Young Ju Yun, Jeongjin Lee, Sung-Gyu Lee
To determine the feasibility of using UltraFast Doppler in post-operative evaluation of the hepatic artery (HA) after liver transplantation (LT), we evaluated 283 simultaneous conventional and UltraFast Doppler sessions in 126 recipients over a 2-mo period after LT, using an Aixplorer scanner The Doppler indexes of the HA (peak systolic velocity [PSV], end-diastolic velocity [EDV], resistive index [RI] and systolic acceleration time [SAT]) by retrospective analysis of retrieved waves from UltraFast Doppler clips were compared with those obtained by conventional spectral Doppler...
August 23, 2017: Ultrasound in Medicine & Biology
Won Hwa Kim, Hye Jung Kim, Jin Hyang Jung, Ho Yong Park, Jeeyeon Lee, Wan Wook Kim, Ji Young Park, Hyejin Cheon, So Mi Lee, Seung Hyun Cho, Kyung Min Shin, Gab Chul Kim
Ultrasonography-guided fine-needle aspiration (US-guided FNA) for axillary lymph nodes (ALNs) is currently used with various techniques for the initial staging of breast cancer and tagging of ALNs. With the implementation of the tattooing of biopsied ALNs, the rate of false-negative results of US-guided FNA for non-palpable and suspicious ALNs and concordance with sentinel lymph nodes were determined by node-to node analyses. A total of 61 patients with breast cancer had negative results for metastasis on US-guided FNA of their non-palpable and suspicious ALNs...
August 19, 2017: Ultrasound in Medicine & Biology
Jonathan H Langdon, Etana Elegbe, Raul S Gonzalez, Laurentius Osapoetra, Tristan Ford, Stephen A McAleavey
The clinical use of elastography for monitoring fibrosis progression is challenged by the subtle changes in liver stiffness associated with early-stage fibrosis and the comparatively large variance in stiffness estimates provided by elastography. Single-tracking-location (STL) shear wave elasticity imaging (SWEI) is an ultrasound elastography technique previously found to provide improved estimate precision compared with multiple-tracking-location (MTL) SWEI. Because of the improved precision, it is reasonable to expect that STL-SWEI would provide improved ability to differentiate liver fibrosis stage compared with MTL-SWEI...
August 19, 2017: Ultrasound in Medicine & Biology
Takuro Ishii, Billy Y S Yiu, Alfred C H Yu
Voiding dysfunction that results from bladder outlet (BO) obstruction is known to alter significantly the dynamics of urine passage through the urinary tract. To non-invasively image this phenomenon on a time-resolved basis, we pursued the first application of a recently developed flow visualization technique called vector projectile imaging (VPI) that can track the spatiotemporal dynamics of flow vector fields at a frame rate of 10,000 fps (based on plane wave excitation and least-squares Doppler vector estimation principles)...
August 19, 2017: Ultrasound in Medicine & Biology
David Owen Cosgrove
No abstract text is available yet for this article.
August 17, 2017: Ultrasound in Medicine & Biology
Lars-Arne Schaafs, Heiko Tzschätzsch, Markus van der Giet, Alexander Reshetnik, Ingo G Steffen, Bernd Hamm, Jürgen Braun, Ingolf Sack, Thomas Elgeti
Stiffening of central large vessels is considered a key pathophysiologic factor within the cardiovascular system. Current diagnostic parameters such as pulse wave velocity (PWV) indirectly measure aortic stiffness, a hallmark of coronary diseases. The aim of the present study was to perform elastography of the proximal abdominal aorta based on externally induced time-harmonic shear waves. Experiments were performed in 30 healthy volunteers (25 young, 5 old, >50 y) and 5 patients with longstanding hypertension (PWV >10 m/s)...
August 14, 2017: Ultrasound in Medicine & Biology
Kevin J Parker
No abstract text is available yet for this article.
August 12, 2017: Ultrasound in Medicine & Biology
Yanrong Guo, Changfeng Dong, Haoming Lin, Xinyu Zhang, Huiying Wen, Yuanyuan Shen, Tianfu Wang, Siping Chen, Yingxia Liu, Xin Chen
The aim of this study is to evaluate the utility of acoustic radiation force impulse (ARFI) elastography for assessing hepatic fibrosis stage and non-alcoholic fatty liver disease (NAFLD) severity, as well as the relationship among hepatic histologic changes using shear wave velocity (SWV). Animal models with various degrees of NAFLD were established in 110 rats. The right liver lobe was processed and embedded in a fabricated gelatin solution (porcine skin). Liver mechanics were measured using SWV induced by acoustic radiation force...
August 12, 2017: Ultrasound in Medicine & Biology
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