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Annals of Clinical and Laboratory Science

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https://www.readbyqxmd.com/read/28801382/false-positive-hiv-result-and-low-cd4-in-babesiosis
#1
LETTER
Nabil Mesiha, Marc Whitman, Daniel Goldsmith, Ekaterina Vypritskaya, Saba Hasan
No abstract text is available yet for this article.
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801381/fluoroquinolone-resistance-mechanisms-by-molecular-epidemiologic-study-of-ciprofloxacin-nonsusceptible-escherichia-coli-sequence-types-isolated-from-clinical-specimens-in-a-tertiary-care-university-hospital-in-korea-emergence-of-clone-st131-2006-2008
#2
Hyung-Seok Yang, Youngjin Kim, Sun Young Cho, You Sun Nam, Tae Sang Oh, Kyung-Sun Park, Hyun-Chul Kim, Hee Joo Lee
To investigate the sequence types (STs) and fluoroquinolone resistance related mutations among ciprofloxacin (CIP)-non-susceptible extended-spectrum β-lactamase (ESBL)-producing E. coli isolated from Korean patients from 2006-2008. The prevalence of fluoroquinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, and parE and plasmid-mediated quinolone resistance (PMQR) genes were also studied. Multilocus sequence typing (MLST) was performed to identify STs. The most common ST was ST131 (33/51, 64...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801380/vitamin-d-and-immunomodulation-is-it-time-to-change-the-reference-values
#3
Giulia Bivona, Luisa Agnello, Marcello Ciaccio
The term "vitamin D" refers to two chemical compounds - ergosterol, or vitamin D2, and cholecalciferol, or vitamin D3. Active vitamin D3 is correctly regarded as a neurohormone due to its pleiotropic biological activities. Although the relation between vitamin D and calcium-phosphorus metabolism has never been discussed, the knowledge on many other roles vitamin D plays is growing fast. Briefly, vitamin D immunomodulation includes attenuation and stimulation of Th1 and Th2 cell proliferation, respectively. Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-α, IFN-γ) cytokines, respectively...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801379/historical-perspectives-current-status-and-ethical-issues-in-granulocyte-transfusion
#4
REVIEW
Kimberly Klein, Brian Castillo
The goal of this commentary is to provide a historical aspect of granulocyte transfusion, present practices in granulocyte transfusion, accentuate the complexity of the issue, and foster contemplation of ethical issues assimilated with this practice. Clinical aspects of granulocyte transfusion in the light of ethical issues are also discussed.
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801378/relationship-between-mir-146a-rs2910164-g-c-polymorphism-and-digestive-system-cancer-susceptibility-a-meta-analysis
#5
Xin Xiong, Junfeng Yan, Linghua Li, Yun Li, Yi Cao, Yi Tu, Jinhong Mei
MicroRNAs (miRNAs) are identified negatively regulating gene expression and acting as oncogenes or tumor suppressors in tumorigenesis. The association between miR-146a rs2910164 (G>C) polymorphism and susceptibility to digestive system cancers was contradictory and inconsistent in previously published studies. Presently, we performed a comprehensive literature retrieve on PubMed, Web of Science, Embase, Wanfang and CNKI databases to identify all relevant studies published before July 30, 2016. Odds ratio (OR) and 95% confidential interval (95%CI) were used to calculate the relationship between miR-146a rs2910164 (G>C) polymorphism and digestive system cancers susceptibility...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801377/ethnic-differences-in-genetic-ion-channelopathies-associated-with-sudden-cardiac-death-a-systematic-review-and-meta-analysis
#6
Tim Kong, Joseph Feulefack, Kim Ruether, Fan Shen, Wang Zheng, Xing-Zhen Chen, Consolato Sergi
BACKGROUND AND AIMS: Reports of allele frequencies encoding ion channel, or their interacting proteins associated with sudden cardiac death among different ethnic groups have been inconsistent. Here, we aimed to characterize the distribution of these genes and their alleles among various ethnicities through meta-analysis. METHODS: We conducted a systematic review and meta-analysis to assess the mean allele frequencies of channelopathy genes SCN5A, NOS1AP, KCNH2, KCNE1, and KCNQ1 among the Black, Caucasian, Asian, and Hispanic ethnicities...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801376/cellular-blue-nevus-of-perilimbal-conjunctiva-a-case-report-and-review-of-literature
#7
Tiangeng He, Chunjie Mao, Dongbo Xu, Hua Yan
Cellular blue nevus is an uncommon neoplasm in the conjunctiva. Here we present an unusual case of a cellular blue nevus that clinically resembled conjunctival melanoma. A 29-year-old Chinese male was found to have a giant pigmented lesion of the conjunctiva around the limbal area of right eye from birth. Excisional biopsy with no-touch technique, lamellar corneal transplantation, amniotic membrane transplantation and adjuvant cryotherapy were performed. Histopathology revealed a nodular, well-defined tumor, which was composed of heavily pigmented dendritic cells and less pigmented spindle cells...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801375/primary-pure-endometrial-primitive-neuroectodermal-tumors-with-ewsr1-gene-rearrangement-report-of-2-cases
#8
Binara Assylbekova, Amal Kanbour-Shakir, Kavita Varma, Rohit Bhargava, Esther Elishaev
Primary Primitive Neuroectodermal Tumor (PNET) of the female genital tract is very rare. The majority has been described in ovaries, and the endometrium is an even rarer site. Herein we describe 2 cases of primary uterine corpus PNET cases with EWSR1 FISH confirmation. To the best of our knowledge, there are four cases reported in the English literature. The knowledge of these tumors' incidence in the endometrium is important to keep in mind, to differentiate it from poorly differentiated and undifferentiated adenocarcinomas, should such pattern of growth be encountered...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801374/myeloid-sarcoma-in-a-patient-with-myelodysplastic-syndrome-associated-with-del-5q-case-report-and-literature-review
#9
Josh A Showalter, Nidhi Tandon, Bihong Zhao, Guilin Tang, Nghia D Nguyen, L Jeffrey Medeiros
OBJECTIVE: Myeloid sarcoma (MS) is defined in the World Health Organization classification as a tumor mass consisting of myeloblasts with or without maturation and involving any anatomic site other than the bone marrow. We present a case of MS developing in a patient with 5q- myelodysplastic syndrome (MDS) and review the relevant literature. METHODS: A 77-year-old woman with recent diagnosis of MDS associated with del(5q) presented with symptoms and signs attributable to a mass involving the T8 vertebra...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801373/metformin-and-melatonin-in-adrenocortical-carcinoma-morphoproteomics-and-biomedical-analytics-provide-proof-of-concept-in-a-case-study
#10
Robert E Brown, Jamie Buryanek, Mary F McGuire
Metformin has been proposed as a novel anti-cancer drug for adrenocortical carcinoma (ACC) based upon Poli's recent preclinical studies that 1. "in vitro" metformin modulates the ACC cell model H295R and 2. "in vivo" metformin inhibits tumor growth in a xenograft model as confirmed by a significant reduction of Ki67 [1]. Here we report on our prior clinical case study that provides proof of concept for Poli's studies. We were requested to perform morphoproteomic analysis to further define the biology of, and raise targeted therapeutic options, for a case of post-treatment and chemoresistant ACC metastatic to the liver and the lung...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801372/multi-variant-genetic-panel-for-genetic-risk-of-opioid-addiction
#11
Keri Donaldson, Laurence Demers, Kirk Taylor, Joe Lopez, Sherman Chang
Over 116 million people worldwide have chronic pain and prescription dependence. In the US, opioids account for the majority of overdose deaths, and in 2014, almost 2 million Americans abused or were dependent on prescription opioids. Genetic factors may play a key role in opioid prescription addiction. Herein, we describe genetic variations between opioid addicted and non-addicted populations and derive a predictive model determining risk of opioid addiction. This case cohort study compares the frequency of 16 single nucleotide polymorphisms involved in the brain reward pathways in patients with and without opioid addiction...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801371/small-intestinal-bacterial-overgrowth-may-increase-the-likelihood-of-lactose-and-sorbitol-but-not-fructose-intolerance-false-positive-diagnosis
#12
Tsachi Tsadok Perets, Dalal Hamouda, Olga Layfer, Olga Ashorov, Doron Boltin, Sigal Levy, Yaron Niv, Ram Dickman
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is defined as a bacterial count of more than 10(5) colony-forming units per milliliter in duodenal aspirate. It shares many symptoms with carbohydrate intolerance, which makes the clinical distinction of the disorders difficult. The aim of the study was to examine the relationship between a positive carbohydrate breath test and the presence of SIBO suggested by a positive lactulose hydrogen breath test. METHODS: The electronic database of the gastroenterology laboratory of a tertiary medical center was searched for all patients clinically tested for SIBO in 2012-2013 for whom previous results for lactose, fructose, and/or sorbitol breath test were available...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801370/impact-of-tlr-2-tlr-4-activation-on-the-expression-of-abca1-and-abcg1-in-raw-cells
#13
Kana Suzuki, Yasushi Kawakami, Kazuyoshi Yamauchi
Toll-like receptors (TLR) activation is thought to modulate the macrophage cholesterol efflux and contribute to the atherosclerosis progression; however, the precise pathophysiological mechanism remains unclear. We investigated the effects of TLR2- and TLR4-activation on the expression of the ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 in a mouse macrophage cell line, Raw 264.7. Both TLR2- and TLR4-activation upregulated the expression of ABCA1 mRNA but downregulated that of ABCG1 mRNA. These alterations may be mainly regulated by the following 3 cascades: (1) the TLR/myeloid differentiation primary-response protein 88/Liver X receptor pathway, which upregulated the ABCA1 mRNA; (2) NF-κB pathway, which downregulated the ABCG1 mRNA, and (3) the p38 pathway, which upregulated and stabilized ABCA1 mRNA...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801369/hepatitis-b-virus-upregulates-the-expression-of-c-reactive-protein-both-in-vivo-and-in-vitro
#14
Shiyong Hao, Yan Wang, Guosheng Gao, Zhishan Li
Hepatitis B virus (HBV) infection induces immune-mediated inflammatory responses. The C-reactive protein (CRP) is an inflammatory marker that is synthesized by the liver. The aim of the present study was to investigate the effect of HBV infection on the expression of CRP and its clinical significance. A reverse transcription-polymerase chain reaction (RT-PCR) analysis was employed to examine the expression of CRP mRNA in the human hepatocellular carcinoma (HCC) cell lines HepG2 and HepG2.2.15. A fully automatic biochemical analyzer was used to examine the serum levels of CRP in patients with chronic HBV infections and in healthy controls...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801368/analysis-of-separation-of-white-blood-cells-in-peripheral-blood-as-an-indicator-of-mpo-deficiency
#15
Kinga Rośniak-Bąk, Agnieszka Jeleń, Marek Bąk
The purpose of this study was to analyze the white blood cell (WBC) percentage pattern of patients with myeloperoxidase disorder. During the 18 months of routine work, 36 blood samples were found with disorders of myeloperoxidase activity: 12 cases of total myeloperoxidase (MPOt) deficiency and 24 cases of partial myeloperoxidase (MPOp) deficiency. In the group with MPOp, according to the results, monocytes (MONO) were the dominant population 33.2%±21.3; however, the microscopic evaluation of leucocytes showed the dominance of neutrophil (NEUT)...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801367/comparison-of-hematological-aspects-between-neuroblastoma-patients-with-and-without-bone-marrow-infiltration
#16
Weida Wang, Xiongwen Peng, Cuirong Liang, Hao Chen, Yingchun Zhang, Xiaofei Sun, Leyuan Shen, Yue Lu
Bone marrow involvement in neuroblastoma indicates an advanced stage of the disease. In this study, we retrospectively analyzed the bone marrow infiltration status and hematological parameters of 111 cases of neuroblastoma. Among the 111 cases, 62 (55.9%) exhibited marrow infiltration. Erythrocytopenia, anemia, and thrombocytopenia were significantly (p<0.05) associated with marrow infiltration of >10% malignant cells. The evaluation of blood cell count parameters with receiver operating characteristic curves indicated that erythrocytopenia can substantially improve the accurate prediction of the risk of bone marrow involvement with a Youden index of 0...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801366/fullerenes-may-cause-eif-mediated-perturbation-in-translational-machinery-evidence-from-in-silico-analysis
#17
Sumbul Firdaus, Anupam Dhasmana, Mohd Wahid, Arshad Jawed, Raju K Mandal, Sajad A Dar, Mohammed Y Areeshi, Mohtashim Lohani, Shafiul Haque
GOALS: Fullerenes have tremendous potential for human biological studies which may further lead to their therapeutic applications. Hence, it has become necessary to explore the possibility of their interference with various important cellular processes. The current study was designed to explore how the presence of fullerenes can affect the binding of DNA with different enzymes and factors involved in transcription and translation process. METHODS: Various bioinformatics approaches and software programs were used to study the effect of fullerenes on the binding pattern of DNA with different enzymes and factors involved in transcription and translation process...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801365/overexpression-of-satb1-gene-inhibits-the-immunosuppressive-function-of-regulatory-t-cells-in-chronic-hepatitis-b
#18
Yiyin Wang, Xuefen Li, Haishen Kong, Qiaoyun Zhu, Yuejiao Dong, Xia Liu, Yu Chen
Special AT-rich sequence-binding protein 1 (SATB1) is a class of nuclear matrix binding protein expressed by T cells and plays an important role in regulatory T cells (Tregs) mediated immune regulation. The immunosuppressive function of Tregs in chronic hepatitis B (CHB) being inhibited by SATB1 has been shown in our previous studies. The objective of this study was to learn the impact of SATB1 on the cellular immune function of CHB. SATB1 isolated from human peripheral blood mononuclear cells (PBMCs) was used as a template of PCR and its product was connected to vector PLV-EF1α-EGFP-N...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801364/cd47-is-not-over-expressed-in-fibrolamellar-hepatocellular-carcinoma
#19
Tabitha Cooney, Michael C Wei, Arun Rangaswami, Lei Xu, Julien Sage, Florette K Hazard
OBJECTIVES: CD47 is a transmembrane receptor that inhibits phagocytosis. Over-expression of CD47 is associated with an increased risk of tumor growth and metastasis. Clinical trials based on anti-CD47 therapy in adults are underway in a variety of malignancies. CD47 has been shown to be over-expressed in conventional hepatocellular carcinoma (HCC), a common liver tumor in adults. To our knowledge, there have been no studies to evaluate CD47 expression in the fibrolamellar subtype of HCC (FL-HCC), common in children and young adults...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28801363/l-selectin-promotes-the-maturation-of-dendritic-cells-via-up-regulation-the-expression-of-tlr4-in-vitro
#20
Zhishuai Ye, Jia Liu, Jie Zheng, Jianing Zhang, Rongchong Huang
The relationship between dendritic cells (DCs) and L-selectin in the progress of atherosclerosis is unclear. Here, we used L-selectin co-cultured with DCs to investigate the effect of L-selectin on the maturation of DCs in vitro Monocytes derived DCs were isolated and cultured from human peripheral blood. After being stimulated with L-selectin and/or its antagonist for 24-48 hours, the feather of cells was observed by the electron microscope. The expression of mature antigens CD1a, CD80, CD83, and CD86 were investigated by flow cytometric analysis (FACS)...
August 2017: Annals of Clinical and Laboratory Science
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