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Survey of Ophthalmology

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https://www.readbyqxmd.com/read/28069494/intraocular-inflammatory-mass-associated-with-lens-induce-uveitis
#1
REVIEW
Jean Guffey Johnson, Curtis E Margo
Intraocular inflammatory tumefactions large enough to simulate neoplasms are uncommon. We report a patient with a large intraocular inflammatory mass composed of cells with features of histiocytes and myofibroblasts that was associated with lens-induced uveitis. The spindle cell mass appears to have arisen as an exaggerated response to exposed lens fibers. Although information from immunohistochemistry and cytogenetics has advanced the classification of inflammatory tumefactions, this case highlights the challenges in establishing the nature of these lesions...
January 6, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28062197/assessment-of-patient-reported-outcomes-in-retinal-diseases-a-systematic-review
#2
Mallika Prem Senthil, Jyoti Khadka, Konrad Pesudovs
Advances in the understanding of the genetic, molecular and cellular biology of retinal diseases have led to the development of new treatments. These expanding treatment options demand appropriate outcome measures for studies of treatment benefit including patient-reported outcomes (PRO). A plethora of PRO instruments assess impacts of retinal diseases from the patients' perspectives. We review all of the studies that implemented PRO assessment in retinal diseases and also discuss quality assessment of the PRO instruments...
January 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28062196/radiotherapeutic-and-surgical-management-of-iris-melanoma-a-review
#3
REVIEW
Marko Popovic, Iqbal Ike K Ahmed, Julia DiGiovanni, Carol L Shields
We compare outcomes following radiotherapeutic and surgical management of iris melanoma. Endpoints included local tumor recurrence, metastases, and common complications. From an initial search that yielded 231 articles, we found 17 relevant studies with 761 eyes. The gender distribution was balanced with a mean age of 52 years. Most studies focused on either proton beam (49.4%) or plaque (31.4%) radiotherapy. Rates of local recurrence (range: 0-8%) and metastatic development (0-5%) were favorable following radiotherapy; however, common complications included cataract (36-73%), glaucoma (3-92%) and corneal conditions (0-33%)...
January 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012879/dermatofibroma-of-the-eyelid-with-monster-cells
#4
Frederick A Jakobiec, Yufei Tu, Fouad R Zakka, Arthur K F Tong
Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A 64-year-old woman developed a recurrent lesion of the right lower eyelid. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted and hyperchromatic nucleus. The presence of these cells does not signify a malignant transformation. The background cells were either histiocytoid (many were adipophilin-positive), spindled cells, or dendritiform cells without mitoses...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012878/viral-posterior-uveitis
#5
REVIEW
Joanne H Lee, Aniruddha Agarwal, Padmamalini Mahendradas, Cecilia S Lee, Vishali Gupta, Carlos E Pavesio, Rupesh Agrawal
The causes of posterior uveitis can be divided into infectious, autoimmune, or masquerade syndromes. Viral infections. a significant cause of sight-threatening ocular diseases in the posterior segment,, include human herpesviruses, measles, rubella, and arboviruses such as dengue, West Nile, and chikungunya virus. Viral posterior uveitis may occur as an isolated ocular disease in congenital or acquired infections or as part of a systemic viral illness. Many viruses remain latent in the infected host with a risk of reactivation that depends on various factors, including virulence and host immunity, age, and comorbidities...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012877/optimising-cataract-surgery-in-patients-with-age-related-macular-degeneration
#6
REVIEW
Boon Lin Teh, Roly Megaw, Shyamanga Borooah, Baljean Dhillon
Age-related macular degeneration (AMD) is one of the leading causes of visual impairment. The development of cataract in AMD patients poses challenges in assessing timing of surgery, predicting potential benefit to the patient of surgery, and predicting short and long term effects of surgery on progression of their AMD. Although traditional cataract surgery remains the mainstay of treatment, recently several devices have been developed to address the specific needs of AMD patients with cataract. We look at the associations between cataract and AMD and outline the treatment approaches to cataract surgery in AMD, looking at the potential benefits and risks of both traditional approaches and newer devices...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012876/in-search-of-a-disease
#7
Gustavo Savino, Andrea Campana, Gianluigi Petrone, Gabriela Grimaldi, Ann P Murchison
A 10-year-old child presented with right eyelid swelling and a palpable orbital mass. Diagnostic evaluation with the aid of excisional biopsy revealed a pseudo- encapsulated mass associated with high levels of serum perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA). Family history of rheumatic diseases, response to treatment with corticosteroids and immunosuppressant drugs and clinical and histopathological features suggested an orbital autoimmune response in which p-ANCA antibodies were detected, and a diagnosis of probable IgG4-related disease was made...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012875/advances-in-understanding-and-management-of-retinopathy-of-prematurity
#8
REVIEW
Mary Elizabeth Hartnett
The understanding, diagnosis and treatment of retinopathy of prematurity (ROP) have changed in the last seventy years since the original description of retrolental fibroplasia associated with high oxygenation. It is now recognized that ROP differs in appearance world-wide and as ever smaller and younger premature infants survive. New methods are being evaluated to image the retina, diagnose severe ROP, and determine windows of time for treatment to save eyes and improve visual and neural outcomes. New treatments to promote physiologic retinal vascular development, vascular repair, and inhibit vasoproliferation by regulating proteins involved in vascular endothelial growth factor, insulin-like growth factor, or erythropoietin signaling...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012874/management-of-high-risk-corneal-transplantation
#9
REVIEW
Antonio Di Zazzo, Ahmad Kheirkhah, Tulio B Abud, Sunali Goyal, Reza Dana
The cornea is the most commonly transplanted tissue in medicine. The main cause of corneal graft failure is allograft rejection. The incidence of graft rejection depends on the presence of high-risk characteristics, most notably corneal neovascularization. Although corneal grafting has a high success rates in the absence of these risk factors, high-risk keratoplasty is associated with low success rates because of a high incidence of immune-mediated graft rejection. To improve the survival of high-risk corneal transplantation, various preoperative, intraoperative, and postoperative measures can be considered...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28012873/posner-schlossman-syndrome
#10
REVIEW
Roly Megaw, Pankaj Kumar Agarwal
Posner-Schlossman syndrome (PSS), or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of non-granulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males . Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28011246/aids-for-eye-drop-administration
#11
REVIEW
Isaiah Davies, Andrew M Williams, Kelly W Muir
One aspect to eye drop adherence is successful instillation of the drops; however, it is well known that many patients struggle with this task. Difficulties may include aiming their drops, extending their neck, preventing excess drop leakage, avoiding contamination of the bottle tip, and generating enough force to expel a drop from the bottle. Instillation aids are devices that aim to ameliorate one or more of these barriers. We review the literature on instillation aids in order to describe the options available to patients and to report evaluations of their efficacy...
December 20, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27998710/optical-coherence-tomography-angiography-octa-and-retinal-microvascular-ramification-in-amn-and-pamm
#12
LETTER
Lana Del Porto, Axel Petzold
No abstract text is available yet for this article.
December 17, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27998709/author-response
#13
LETTER
Kavita V Bhavsar, K Bailey Freund, David Sarraf, Emmett T Cunningham
No abstract text is available yet for this article.
December 17, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27894880/lymphoma-of-the-eyelid
#14
REVIEW
Frederik Holm Svendsen, Steffen Heegaard
Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymphoma (18 cases-9%). T-cell lymphomas are most frequently mycosis fungoides (25 cases-13%), extranodal natural killer/T-cell, nasal-type lymphoma (12 cases-6%), and primary cutaneous anaplastic large-cell lymphoma (12 cases-6%)...
November 26, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27890620/drug-induced-corneal-epithelial-changes
#15
REVIEW
Michael B Raizman, Pedram Hamrah, Edward J Holland, Terry Kim, Francis S Mah, Christopher J Rapuano, Roger G Ulrich
Drugs across many pharmacologic classes induce corneal epithelial changes. Many of these drugs have cationic amphiphilic structures, with a hydrophobic ring and hydrophilic cationic amine side chain that allow them to cross cell membranes. These drugs lead to intracellular phospholipid accumulation, often manifested in the cornea by vortex keratopathy, with no effect on visual acuity and few ocular symptoms. Other drugs, notably antineoplastic agents, produce a fine diffuse corneal haze, sometimes accompanied by decreased vision that can be dose limiting...
November 24, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27890619/primary-iris-leiomyoma
#16
REVIEW
Gabrielle A Yeaney, Sean Platt, Arun D Singh
Intraocular leiomyomas are uncommon and usually occur in the ciliary body. Primary leiomyoma of the iris is both rare and a difficult diagnosis to make, given melanocytic tumors are more common and may be amelanotic. The somewhat controversial diagnosis of iris leiomyoma requires further confirmation by immunohistochemistry and electron microscopy. Herein, we describe a 58-year-old man with a 2-mm round translucent pink lesion of the iris. The tumor was excised by sector iridectomy. Immunohistochemistry showed positivity for both smooth muscle actin and desmin and negativity for S-100, HMB45, SOX10, MelanA, CD31, CD34, and h-caldesmon...
November 24, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27863968/periocular-periorbital-and-orbital-pathology-in-liver-disease
#17
REVIEW
William J Carroll, Travis Peck, Thomas L Jenkins, Zeynel A Karcioglu
Although the connection is not often apparent, hepatic pathology may be associated with ophthalmic disease. We review the literature concerning the periocular, periorbital, and orbital manifestations of various hepatic disorders. This includes periocular or periorbital jaundice, the impact of hepatitis B and C, eyelid changes in cirrhosis, orbital mass lesions in hepatocellular carcinoma, and cutaneous vascular malformations as they are related to liver disease. The motility disorders associated with Wilson disease, the ophthalmic manifestations of Alagille syndrome, and the effects of liver transplantation are also discussed...
November 15, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27856177/diagnostic-criteria-for-limbal-stem-cell-deficiency-a-systematic-literature-review
#18
REVIEW
Lona Jawaheer, Deepa Anijeet, Kanna Ramaesh
PURPOSE: The diagnosis of limbal stem cell deficiency (LSCD) is often based on clinical manifestations with or without the use of tests to demonstrate the presence of goblet cells or of specific epithelial markers on the corneolimbal surface. This systematic review looks at the various diagnostic methods employed in the diagnosis of LSCD in published interventional studies. DESIGN: Systematic literature review METHODS: We did a systematic search on MEDLINE and PUBMED for articles published in English between January 1, 2003 and December 31, 2013...
November 14, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27847308/choroidal-thickness-correlations-and-systemic-disease
#19
LETTER
Solmaz Abdolrahimzadeh
No abstract text is available yet for this article.
November 12, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27847307/the-glue-that-holds-the-situation-together
#20
Kyle J Godfrey, Andrew R Harrison, Bobby S Korn, Don O Kikkawa
A 48-year-old man presented with a longstanding left upper eyelid mass that increased in size when bending forward. The mass was associated with enophthalmos and slowly increased in size with Valsalva maneuver. Magnetic resonance imaging and arteriography demonstrated a vascular malformation without an abnormal arterial component. Because of his increasing pain, the vascular malformation was excised in a multidisciplinary approach involving intraoperative fluoroscopic mapping, cyanoacrylate embolization, and surgical excision...
November 12, 2016: Survey of Ophthalmology
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