journal
https://read.qxmd.com/read/38461962/prednisone-and-ibuprofen-conjugate-janus-dendrimers-and-their-anticancer-activity
#1
JOURNAL ARTICLE
Israel Barajas-Mendoza, Irving Osiel Castillo-Rodríguez, Isabel Hernández-Rioja, Teresa Ramirez-Apan, Marcos Martínez-García
Drug release from hyperbranched Janus dendrimer-drug conjugates and their subsequent activity are influenced by the different drugs in each dendron and the linker. To understand these effects, we synthetized new Janus-type dendrimers of first and second generation. One dendron with 2,2-Bis(hydroxymethyl)propionic acid functionalized with ibuprofen and the second dendron was obtained with 3-aminopropanol-amidoamine and prednisone. The dendrimers were obtained by copper(I)-catalyzed Click azide-alkyne cycloaddition for the formation of a triazole as a dendrimeric nucleus of Janus dendrimer conjugates are reported...
March 8, 2024: Steroids
https://read.qxmd.com/read/38458370/the-effect-of-vitamin-d2-supplementation-on-vitamin-d-levels-in-humans-a-time-and-dose-response-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Fan Zhou, Abdolreza Jamilian, Kousalya Prabahar, Benjamin Hernández-Wolters, Hamed Kord-Varkaneh, Dunyao Bai
BACKGROUND: Inconsistencies exist regarding the influence of vitamin D2 (ergocalciferol) supplementation on serum vitamin D levels. These inconsistencies could be attributed to numerous factors, such as dosage, baseline vitamin D levels, and duration of intervention. Hence, this dose-response meta-analysis of randomized controlled trials was conducted to assess the efficacy of vitamin D2 supplementation on vitamin D levels. METHODS: Relevant studies were searched in PubMed/Medline, Web of Science, Embase, and Scopus, from their inception to 3 January 2023...
March 6, 2024: Steroids
https://read.qxmd.com/read/38458369/potential-targets-of-diosgenin-for-the-treatment-of-oral-squamous-cell-carcinoma-and-their-bioinformatics-and-transcriptional-profiling-analyses
#3
JOURNAL ARTICLE
Yang Xiao, Bingbing Xu, Xiaolan Li, Tianhao Ding, Wenxin Zhao, Xiaoxue Nie, Junxia Mu, Zhiyou Xiao, Qian Wang, Qunli Ren, Enkui Zhang
Diosgenin can inhibit the proliferation and cause apoptosis of various tumor cells, and its inhibitory effect on oral squamous cell carcinoma (OSCC) and its mechanism are still unclear. In this study, we predicted the targets of diosgenin for the treatment of OSCC through the database, then performed bioinformatics analysis of the targets, and further verified the effect of diosgenin on the activity of OSCC cell line HSC-3, the transcriptional profile of the targets and the molecular docking of the targets with diosgenin...
March 6, 2024: Steroids
https://read.qxmd.com/read/38452910/bio-oxidation-of-progesterone-by-penicillium-oxalicum-cbmai-1185-and-evaluation-of-the-cytotoxic-activity
#4
JOURNAL ARTICLE
Thayane Melo de Queiroz, Talita A Valdes, Andrei Leitão, André L M Porto
We report the biotransformation of progesterone 1 by whole cells of Brazilian marine-derived fungi. A preliminary screening with 12 fungi revealed that the strains Penicillium oxalicum CBMAI 1996, Mucor racemous CBMAI 847, Cladosporium sp. CBMAI 1237, Penicillium oxalicum CBMAI 1185 and Aspergillus sydowii CBMAI 935 were efficient in the biotransformation of progesterone 1 in the first days of the reaction, with conversion values ranging from 75 % to 99 %. The fungus P. oxalicum CBMAI 1185 was employed in the reactions in quintuplicate to purify and characterize the main biotransformation products of progesterone 1...
March 5, 2024: Steroids
https://read.qxmd.com/read/38437943/a-unified-total-synthesis-route-to-18-trideuterated-and-or-19-trideuterated-testosterone-androstenedione-and-progesterone
#5
JOURNAL ARTICLE
Mingxing Qian, Douglas F Covey
A unified total synthesis route has been used to prepare 18- and 19-trideuterated testosterone, androstenedione and progesterone. The 18-trideuterated steroid synthetic method starts with the synthesis of 2-(methyl-d3)-1,3-cyclopentanedione from CD3I and 1,3-cyclopentanedione and is subsequently converted into the Hajos-Parrish ketone for synthesis of these trideuterated steroids. The 19-trideuterated steroid synthesis proceeds through non-deuterated Hajos-Parrish ketone with incorporation of the 19-methyl-d3 group from CD3I at a later stage of the same synthetic route...
March 2, 2024: Steroids
https://read.qxmd.com/read/38367679/new-ring-a-modified-cycloartane-triterpenoids-from-dysoxylum-malabaricum-bark-isolation-structure-elucidation-and-their-cytotoxicity
#6
JOURNAL ARTICLE
Nivedita Bhardwaj, Priyamvada Gupta, Nancy Tripathi, Sanheeta Chakarbarty, Ashish Verma, Sanju Kumari, Vibhav Gautam, G Ravikanth, Shreyans K Jain
The Genus Dysoxylum (Meliaceae) consists of approximately 80 species that are abundant in structurally diverse triterpenoids. The present study focused on isolating new triterpenoids from the bark of Dysoxylum malabaricum, one of the predominant species of Dysoxylum present in India. The methanol-dichloromethane bark extract was subjected to LCMS profiling followed by silica gel column chromatography and HPLC analysis to target new compounds. Two new ring A-modified cycloartane-type triterpenoids were isolated from the bark extract...
February 15, 2024: Steroids
https://read.qxmd.com/read/38354995/comparing-the-efficacy-of-corticosteroids-among-patients-with-community-acquired-pneumonia-in-the-icu-versus-non-icu-settings-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Luis A Diaz Caballero, Ashnah Aijaz, Neha Saleem Paryani, Samar Mahmood, Madiha Salman, Mohammad Omer Khan, Dayal Ahluwalia, Mohammad Arham Siddiq, Ishaque Hameed
BACKGROUND: Despite the potential of corticosteroids in treating community-acquired pneumonia (CAP), conflicting evidence exists regarding their effect on mortality. To address this gap and provide new insights, we conducted a pre-specified subgroup meta-analysis of corticosteroid use in CAP patients, focusing on the ICU versus non-ICU subsets. METHODS: We searched PubMed, Cochrane Central Register of Controlled Trials and SCOPUS from inception to May 2023 for randomized controlled trials (RCTs)...
February 12, 2024: Steroids
https://read.qxmd.com/read/38325751/an-asiatic-acid-derived-trisulfamate-acts-as-a-nanomolar-inhibitor-of-human-carbonic-anhydrase-va
#8
JOURNAL ARTICLE
Toni C Denner, Niels V Heise, Immo Serbian, Andrea Angeli, Claudiu T Supuran, René Csuk
This investigation delves into the inhibitory capabilities of a specific set of triterpenoic acids on diverse isoforms of human carbonic anhydrase (hCA). Oleanolic acid (1), maslinic acid (2), betulinic acid (3), platanic acid (4), and asiatic acid (5) were chosen as representative triterpenoids for evaluation. The synthesis involved acetylation of parent triterpenoic acids 1-5, followed by sequential reactions with oxalyl chloride and benzylamine, de-acetylation of the amides, and subsequent treatment with sodium hydride and sulfamoyl chloride, leading to the formation of final compounds 21-25...
February 5, 2024: Steroids
https://read.qxmd.com/read/38311094/filamin-a-in-triple-negative-breast-cancer
#9
REVIEW
Pia Giovannelli, Marzia Di Donato, Fabrizio Licitra, Emilia Sabbatino, Viviana Tutino, Gabriella Castoria, Antimo Migliaccio
Triple-negative breast cancer is a rare but highly heterogeneous breast cancer subtype with a limited choice of specific treatments. Chemotherapy remains the only efficient treatment, but its side effects and the development of resistance consolidate the urgent need to discover new targets. In TNBC, filamin A expression correlates to grade and TNM stage. Accordingly, this protein could constitute a new target for this BC subtype. Even if most of the data indicates its direct involvement in cancer progression, some contrasting results underline the need to deepen the studies...
February 2, 2024: Steroids
https://read.qxmd.com/read/38309552/validation-of-a-lc-ms-ms-method-for-establishing-reference-intervals-and-assessing-diagnostic-performance-of-urinary-free-cortisol-and-cortisone
#10
JOURNAL ARTICLE
Yan Song, Juan Zhao, Dan Liu, Jie Zhang
BACKGROUND: 24-h urinary free cortisol (UFF) is recommended for screening of Cushing's syndrome (CS), a rare disease characterized by apparent cortisol and cortisone excess. We aimed to validate a simple LC-MS/MS method for accurate measurement of UFF and urinary free cortisone (UFE), establishment of reference ranges, and evaluation of performance for CS diagnosis. METHODS: Urine samples were processed using solid-phase extraction cartridges, followed by elution with methanol and acetonitrile...
February 1, 2024: Steroids
https://read.qxmd.com/read/38286318/an-unexpected-conversion-of-2e-furfurylidene-3-oxo-24-nor-allobetulin-to-23-nor-allobetulins
#11
JOURNAL ARTICLE
Liana Zakirova, Irina Baikova, Alexander Lobov, Olga Kukovinets, Oxana Кazakova
A series of 2E-furfurylidene-23-nor- and 24-nor-allobetulins has been synthesized by the Claisen-Schmidt condensation and conditions of their formation were studied in detail. It was found that among an expected 2E-furfurylidene-3-oxo-24-nor-allobetulin 4 two byproducts holding 3-oxo-4α-hydroxy- 5 and 3β,4α-dihydroxy- 6 substituents were formed, which could become the main products under the change of reaction time and amount of the base solution. Moreover, a conversion of individual 2E-furfurylidene-23-nor-3-oxo-4α-hydroxy- 5 into 2E-furfurylidene-23-nor-3β,4α-dihydroxy-derivative 6 under the treatment with the base solution was observed...
January 27, 2024: Steroids
https://read.qxmd.com/read/38278283/remote-functionalization-reactions-in-steroids-discovery-and-application
#12
REVIEW
Paul B Reese
Research published between 2001 and 2022 on the functionalization of remote positions of steroids, as well as the use of this technique in the generation of biologically active compounds has been reviewed. In the first section of the analysis established and novel methods for activation of sites deemed to be remote were reported. A series of manganese- (mainly), rhodium-, ruthenium- and osmium-centered porphyrins as catalysts in the presence of PIDA as oxidant have effected hydroxylation at C-1, -5, -6, -7, -11, -14, -15, -16, -17, -20, -24 and -25...
January 24, 2024: Steroids
https://read.qxmd.com/read/38278282/the-role-of-estrogen-metabolites-in-human-ovarian-function
#13
REVIEW
Soledad Henríquez, Maria Jose Valdivia, Monica Mainigi, Claudio Villarroel, Luis Velasquez, Jerome F Strauss Iii, Luigi Devoto
Estrogens produced by the ovary play diverse roles in controlling physiological changes in the function of the female reproductive system. Although estradiol acts through classical nuclear receptors, its metabolites (EMs) act by alternative pathways. It has been postulated that EMs act through paracrine-autocrine pathways to regulate key processes involved in normal follicular growth, corpus luteum (CL) development, function, and regression. The present review describes recent advances in understanding the role of EMs in human ovarian physiology during the menstrual cycle, including their role in anovulatory disorders and their action in other target tissues...
January 24, 2024: Steroids
https://read.qxmd.com/read/38266463/progesterone-treatment-reduces-food-intake-and-body-weight-in-ovariectomized-female-rats
#14
JOURNAL ARTICLE
Maimi Uchishiba, Shota Yamamoto, Asuka Takeda, Ryosuke Arakaki, Moeka Arata, Hiroki Noguchi, Hidenori Aoki, Kou Tamura, Takaaki Maeda, Saki Minato, Mari Nii, Hiroaki Inui, Shuhei Kamada, Riyo Kinouchi, Yuri Yamamoto, Kanako Yoshida, Shigetaka Yagi, Takeshi Kato, Takashi Kaji, Masato Nishimura, Kazuhiko Ino, Takeshi Iwasa
While the effects of progesterone on body weight and appetite in pre-menopausal conditions have been well elucidated, its effects in post-menopausal conditions have not been clarified. On the contrary, the effects of estrogen on body weight and appetite in post-menopausal conditions have been well established. In this study, the effects of progesterone treatment on body weight, appetite, and fat mass in ovariectomized rats were evaluated. In addition, the central and/or peripheral levels of oxytocin (OT), leptin, and their receptors, which are potent anorectic factors, were examined...
January 23, 2024: Steroids
https://read.qxmd.com/read/38242273/aging-effects-in-adrenal-cortex-of-male-mongolian-gerbil-a-model-for-endocrine-studies
#15
JOURNAL ARTICLE
Mariele Ilario Zucão, Vitor Grigio, Luiz Henrique Alves Guerra, Julia Quilles Antoniassi, Nayara Fernanda da Costa Castro, Sebastião Roberto Taboga, Patricia Simone Leite Vilamaior
The adrenal gland produces steroid hormones that act in the homeostasis of organisms. During aging, alterations in the hormonal balance affect the adrenal glands, but these have not yet been fully described due to the lack of adequate animal models. The adrenal gland of the Mongolian gerbil has a morphology similar to the primate's adrenal gland, which makes it a possible animal model for endocrine studies. Therefore, the current study aimed to study the morphophysiology of the adrenal gland under the effect of aging...
January 18, 2024: Steroids
https://read.qxmd.com/read/38182066/camp-regulates-the-progesterone-receptor-gene-expression-through-the-protein-kinase-a-pathway-during-decidualization-in-human-immortalized-endometrial-stromal-cells
#16
JOURNAL ARTICLE
Alejandra Monserrat Retis-Resendiz, Yesenia Cid-Cruz, Dora María Velázquez-Hernández, Jessica Romero-Reyes, Moisés León-Juárez, Elizabeth García-Gómez, Ignacio Camacho-Arroyo, Edgar Ricardo Vázquez-Martínez
Decidualization, a crucial process for successful pregnancy establishment and maintenance, involves endometrial stromal cell differentiation. This process is orchestrated by estradiol (E2), progesterone, and other stimuli that increase intracellular cyclic adenosine monophosphate (cAMP) levels. The intracellular progesterone receptor (PR), encoded by the PGR gene, has a key role in decidualization. This study aimed to understand the role of sex steroids and cAMP in regulating PGR expression during the in vitro decidualization of the human immortalized endometrial stromal cell line, T-HESC...
January 3, 2024: Steroids
https://read.qxmd.com/read/38176451/impact-of-anabolic-androgenic-steroids-on-covid-19
#17
REVIEW
Khaja Moinuddin Shaik, Vijay Patibandla, Sukhendu Nandi
In the wake of the Novel Coronavirus arrival, the world witnessed the fragility of healthcare systems and the resilience of healthcare workers who stood on the front lines. SARS-CoV-2, also known as COVID-19 or severe acute respiratory syndrome, first appeared in China in December 2019. The infection quickly spread across the nation and the world. All countries severely restricted social interaction to stop the virus's transmission, impacting all sporting, social, and recreational activities. Anabolic androgenic steroids (AASs) are frequently used illegally to enhance strength and physical attractiveness...
January 2, 2024: Steroids
https://read.qxmd.com/read/38096964/the-effects-of-vitamin-d-on-different-types-of-cells
#18
REVIEW
Mária Janubová, Ingrid Žitňanová
Vitamin D is neccessary for regulation of calcium and phosphorus metabolism in bones, affects imunity, the cardiovascular system, muscles, skin, epithelium, extracellular matrix, the central nervous system, and plays arole in prevention of aging-associated diseases. Vitamin D receptor is expressed in almost all types of cells and its activation leads to modulation of different signaling pathways. In this review, we have analysed the current knowledge of 1,25-dihydroxyvitamin D3 or 25-hydroxyvitamin D3 effects on metabolism of cells important for the function of the cardiovascular system (endothelial cells, vascular smooth muscle cells, cardiac cells and pericytes), tissue healing (fibroblasts), epithelium (various types of epithelial cells) and the central nervous system (neurons, astrocytes and microglia)...
February 2024: Steroids
https://read.qxmd.com/read/38135013/editorial-13th-international-meeting-on-rapid-responses-to-steroid-hormones-paris-20-23-september-2022-in-memoriam-anthony-w-norman-1938-2019
#19
EDITORIAL
Yves Jacquot, Patricia de Cremoux, Brian J Harvey, Martin Wehling
No abstract text is available yet for this article.
December 20, 2023: Steroids
https://read.qxmd.com/read/38128896/purinergic-signaling-influences-the-neuroinflammatory-outcomes-of-a-testosterone-derived-synthetic-in-female-rats-resistance-training-protective-effects-on-brain-health
#20
JOURNAL ARTICLE
Aline da Silva Pereira, Nathieli Bianchin Bottari, Jelson Norberto Nauderer, Charles Elias Assmann, Priscila Marquezan Copetti, Karine Paula Reichert, Vitor Bastianello Mostardeiro, Marcylene Vieira da Silveira, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
Physical exercise is recognized as a non-pharmacological approach against several neuroinflammatory conditions and thus prevent brain disorders. However, the search for ergogenic resources by athletes in the sports field and by bodybuilding practitioners in gyms has been increasingly common and on the rise. This practice shortens the process of performance gain and improves aesthetics, having led to the prominent use and abuse of hormones in the past years. Recent evidence has pointed out that the purinergic system, composed of adenine nucleotides, nucleosides, enzymes, and receptors, largely participates in a wide range of functions within the brain, such as neuroinflammation, neuromodulation, and cellular communication...
December 19, 2023: Steroids
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