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Singapore Medical Journal

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https://www.readbyqxmd.com/read/28451695/low-maternal-serum-pregnancy-associated-plasma-protein-a-as-a-risk-factor-of-preeclampsia
#1
Suchaya Luewan, Monrudee Teja-Intr, Supatra Sirichotiyakul, Theera Tongsong
INTRODUCTION: Low levels of pregnancy-associated plasma protein-A (PAPP-A) might be associated with abnormal placentation, leading to the development of preeclampsia in late gestation. We aimed to determine the association between low serum PAPP-A levels and rates of preeclampsia in Thai women with otherwise low-risk pregnancies. METHODS: A cohort study was conducted on consecutive singleton pregnancies, undergoing first trimester screening for fetal Down syndrome, at a tertiary centre hospital...
April 28, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28451694/production-pressures-among-anaesthesiologists-in-singapore
#2
Jia Xin Chai, Shin Yuet Chong
INTRODUCTION: Production pressure is the pressure on personnel to prioritise production ahead of safety. We assessed the prevalence of production pressures among anaesthesiologists in Singapore. METHODS: A random online survey was conducted among local anaesthesiologists. Questions were asked about attitudes to production pressures in the work environment, occurrence of situations involving unsafe actions, and rating on the intensity of external and internal sources of pressure...
April 28, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28367583/does-the-early-introduction-of-solids-promote-obesity
#3
Brian Symon, Georgina E Crichton, Beverly Muhlhausler
Childhood obesity is a major public health challenge across the developed world, and understanding the modifiable factors that contribute to it is vital. The influence of early-life nutrition on predisposition to later obesity and metabolic disease is now well established. Much research has concentrated on the preventative effects of breastfeeding in relation to childhood obesity risk, but the optimal timing of introducing solid foods has received far less attention. This remains a much-debated and contentious issue, with differing guidelines from international bodies, causing confusion among parents...
April 3, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28367582/the-auxiliary-white-coat-effect-in-hospitals-perceptions-of-patients-and-doctors
#4
Kor Woi Tiang, Azad Hassan Abdul Razack, Keng Lim Ng
A doctor's attire is vital for both a positive first impression and the overall healthcare experience of patients. We attempted to understand patients' and doctors' perceptions and preferences regarding six types of dress codes used by doctors in different situations and locations. A total of 87 patients and 46 doctors participated in the study. Separate sets of questionnaires, that included four demographic questions and 14 survey questions, were given to the patient and doctor groups. Most patients preferred doctors dressed formally in white coats irrespective of scenarios or locations whereas majority of doctors preferred formal attire without white coats...
April 3, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28367581/drowning-in-swimming-pools-clinical-features-and-safety-recommendations-based-on-a-study-of-descriptive-records-by-emergency-medical-services-attending-to-995-calls
#5
Joanna Shi-En Chan, Marie Xin Ru Ng, Yih Yng Ng
INTRODUCTION: This study was a descriptive analysis of national ambulance case records, aimed at making practical safety recommendations in order to reduce the incidence of drowning in swimming pools. METHODS: A search was performed on a national database of descriptive summaries by first responder paramedics of all 995 calls made to the Singapore Civil Defence Force between 1 January 2012 and 31 December 2014. We included all cases of submersion in both public and private pools for which emergency medical services were activated...
April 3, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28261742/endobronchial-lipoma
#6
Charlene Jy Liew, Kah Yee Tham, Angeline Cc Poh, Augustine Tee
No abstract text is available yet for this article.
March 6, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28261741/panbesy-induced-coronary-vasospasm
#7
Mohammed Rizwan Amanullah, Khim Leng Tong
No abstract text is available yet for this article.
March 6, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210748/risk-factors-associated-with-abdominal-obesity-in-suburban-adolescents-from-a-malaysian-district
#8
Wai Fong Chew, Pooi Pooi Leong, Sook Fan Yap, A Malik Yasmin, Kong Bung Choo, Gary Kim Kuan Low, Nem Yun Boo
INTRODUCTION: We aimed to determine the risk factors associated with abdominal obesity (AO) in suburban adolescents. METHODS: This cross-sectional study included adolescents aged 15-17 years from five randomly selected secondary schools in the Hulu Langat district of Selangor State, Malaysia. Waist circumference (WC) was measured at the midpoint between the lower margin of last palpable rib and the top of iliac crest. Information on sociodemographic data, dietary habits, physical activity levels and duration of sleep was obtained via interviewer-administered questionnaires...
February 17, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210747/extent-of-field-change-in-colorectal-cancers-with-braf-mutation
#9
Aaron Poh, Heidi Sian Ying Chang, Kok Yang Tan, Xin Xiu Sam, Avery Khoo, Shoa Nian Choo, Min En Nga, Wei Keat Wan
INTRODUCTION: Sporadic colorectal cancers with BRAF mutations constitute two distinct subgroups of colorectal cancers. Recent studies have linked the presence of the BRAF mutation to a familial inheritance pattern. This was a proof-of-concept study that aimed to examine: (a) the extent of field change in sporadic colorectal cancers with BRAF mutation; and (b) the extent of resection margins required and the pattern of DNA mismatch repair protein loss in these tumours. METHODS: Eight microsatellite instability-high (MSI-H) tumours with positive BRAF mutation from an existing histopathological database were selected for BRAF mutation and mismatch repair protein analysis...
February 17, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429037/double-jeopardy-in-acute-st-segment-elevation-myocardial-infarction
#10
Rajiv Ananthakrishna, Li-Jun Wang, Liang Ping Zhao, Huay Cheem Tan
No abstract text is available yet for this article.
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429036/a-review-of-zika-virus-infections-in-pregnancy-and-implications-for-antenatal-care-in-singapore
#11
Harvard Zhenjia Lin, Paul Anantharajah Tambyah, Eu Leong Yong, Arijit Biswas, Shiao-Yng Chan
Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429035/max-theiler-1899-1972-creator-of-the-yellow-fever-vaccine
#12
Siang Yong Tan, Kate Pettigrew
No abstract text is available yet for this article.
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429034/authors-reply
#13
Song Tao Timothy Cheo, Keith Hsiu Chin Lim
No abstract text is available yet for this article.
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429033/clinics-in-diagnostic-imaging-176-acute-embolic-occlusion-of-the-coeliac-artery
#14
Chinthaka Appuhamy, Justin Kwan, Martin Weng Chin H'ng, Sriram Narayanan, Sundeep Punamiya
A 52-year-old man, who had a background of chronic heart disease and atrial fibrillation, as well as non-compliance with warfarin therapy, presented with a two-week history of worsening upper abdominal pain. Computed tomography mesenteric angiography showed complete embolic occlusion of the coeliac artery with resultant segmental splenic infarction, and thrombus within the left ventricle. A decision was made to proceed with catheter-directed thrombolysis. Subsequent follow-up angiogram at 12 hours showed successful treatment with complete dissolution of the coeliac embolus...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429032/obstructive-sleep-apnoea-and-type-2-diabetes-mellitus-are-they-connected
#15
Yingjuan Mok, Chee Wei Tan, Hang Siang Wong, Choon How How, Kah Leong Alvin Tan, Pon Poh Hsu
Obstructive sleep apnoea (OSA), a sleep-related breathing condition, is diagnosed based on a patient's apnoea-hypopnea index from a sleep study, and the presence or absence of symptoms. Diabetes mellitus (DM) and OSA share a significant common risk factor, obesity, with all three conditions contributing to the risk of developing cardiovascular diseases. The pathophysiological links between OSA and DM are still unclear, but intermittent hypoxia may be an important mechanism. More awareness of the possible link between OSA and DM is needed, given their increasing prevalence locally and worldwide...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429031/infectious-diseases-in-singapore-and-asia-persistent-challenges-in-a-new-era
#16
Lawrence Soon-U Lee
No abstract text is available yet for this article.
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28429030/comment-on-glioblastoma-multiforme-outcomes-of-107-patients-treated-in-two-local-institutions
#17
John H Lange
No abstract text is available yet for this article.
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/27516114/an-update-on-finances-and-financial-support-for-medical-students-in-yong-loo-lin-school-of-medicine
#18
Andrew Arjun Sayampanathan, Yeong Tze Wilnard Tan, Jie Ming Nigel Fong, Yun Qing Koh, Chew Lip Ng, Niraj Mohan, Jin Hao Justin Jang, Paul Anantharajah Tambyah
INTRODUCTION: Increasing financial challenges have resulted in great debt among medical graduates worldwide. In Singapore, more scholarships and bursaries have been disbursed in recent years to support students who are financially challenged. We aimed to study the financial status of medical students in National University of Singapore (NUS) Yong Loo Lin School of Medicine (i.e. NUS Medicine), Singapore, and the financial support available to them. METHODS: A cross-sectional quantitative study was performed...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/27357316/prognostic-factors-for-candidaemia-in-intensive-care-unit-patients-a-retrospective-analysis
#19
Yasumasa Kawano, Atsushi Togawa, Yoshihiko Nakamura, Mariko Mizunuma, Reiko Yamasaki, Kota Hoshino, Takeshi Nishida, Hiroyasu Ishikura
INTRODUCTION: Candidaemia, recognised as a fairly common disease among intensive care unit (ICU) patients, carries a poor prognosis. However, as studies on the prognostic factors associated with candidaemia in ICU patients are limited, this study aimed to establish the best prognostic factor for ICU patients with candidaemia in a tertiary care hospital in Japan. METHODS: We conducted a retrospective cohort study of patients with candidaemia in the emergency ICU at Fukuoka University Hospital, Fukuoka, Japan, from April 2010 to March 2015...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/27245861/enterovirus-infections-in-singaporean-children-an-assessment-of-neurological-manifestations-and-clinical-outcomes
#20
Wen Yi Thong, Audrey Han, S J Furene Wang, Jeremy Lin, Mas Suhaila Isa, Evelyn Siew Chuan Koay, Stacey Kiat-Hong Tay
INTRODUCTION: Enterovirus infections in childhood can be associated with significant neurological morbidity. This study aimed to describe the prevalence and range of neurological manifestations, determine the clinical characteristics and assess differences in clinical outcomes for Singaporean children diagnosed with enterovirus infections. METHODS: In this single-centre, case-control study, clinical data was collected retrospectively from patients admitted to National University Hospital, Singapore, from August 2007 to October 2011 and diagnosed with enterovirus infection, based on the enterovirus polymerase chain reaction test, or cultures from throat and rectal swabs or cerebrospinal fluid samples...
April 2017: Singapore Medical Journal
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