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Singapore Medical Journal

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https://www.readbyqxmd.com/read/27995262/ethyl-pyruvate-has-anti-apoptotic-and-myocardial-protective-effects-after-regional-ischaemia-reperfusion-myocardial-damage-in-an-in-vivo-rat-model
#1
Haeng Seon Shim, Jeong Heon Park, Yeon A Kim, Jeong Yeol Han, Miyeong Park, Yun Gyu Song, Joon Soo Kim, Il-Woo Shin
INTRODUCTION: The integration of reactive oxygen species is strongly associated with important pathophysiological mechanisms that mediate myocardial ischaemia/reperfusion (I/R) damage. Pyruvate is an efficacious scavenger of reactive oxygen species and a previous study has shown that ethyl pyruvate (EP) has a myocardial protective effect against regional I/R damage in an in vivo rat model. The purpose of this study was to determine whether the myocardial protective effect of EP is associated with anti-apoptosis...
December 20, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27995261/interval-increase-in-the-prevalence-of-symptomatic-cholelithiasis-associated-non-alcoholic-fatty-liver-disease-over-a-ten-year-period-in-an-asian-population
#2
Kevin Beng Chin Khaw, Rachel Huiyi Choi, Juinn Huar Kam, Bibhas Chakraborty, Pierce Kah Hoe Chow
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is frequently associated with cholelithiasis. The prevalence of NAFLD has been on the rise in Asia, but the magnitude of this increase has not been previously studied. METHODS: A retrospective cohort study was carried out on consecutive patients who underwent laparoscopic or open cholecystectomy from November 2001 to November 2004 (cohort 1) and from November 2011 to November 2014 (cohort 2) at Singapore General Hospital...
December 20, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27957585/coronary-artery-calcium-score-and-coronary-computed-tomography-angiography-for-patients-with-asymptomatic-polyvascular-non-coronary-atherosclerosis
#3
Annagrazia Cecere, Graziano Riccioni, Nicola Sforza, Riccardo Marano, Giuseppe Guglielmi
INTRODUCTION: The primary endpoint of this study was to determine the prevalence of coronary artery disease (CAD) and coronary artery calcium score (CACS) using coronary computed tomography angiography (CCTA) among patients with polyvascular atherosclerosis (PVA). Secondary endpoints were to evaluate the prevalence of cardiovascular risk factors and determine the predictors of PVA. METHODS: The presence of atherosclerotic disease was assessed using ultrasonographic vascular examination in 515 asymptomatic patients...
December 13, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27957584/evolution-of-laparoscopic-liver-resection-at-singapore-general-hospital-a-nine-year-experience-of-195-consecutive-resections
#4
Brian Kp Goh, Jin-Yao Teo, Chung-Yip Chan, Ser-Yee Lee, Peng-Chung Cheow, Pierce Kh Chow, London Lpj Ooi, Alexander Yf Chung
INTRODUCTION: We aimed to analyse the changing trends, safety and outcomes associated with the adoption of laparoscopic liver resection (LLR) at a single centre. METHODS: A retrospective review was carried out of 195 patients who underwent LLR from 2006 to 2014 at our institution. To explore the evolution of LLR, the study was divided into three equal consecutive time periods (period 1: 2006-2008; period 2: 2009-2011; and period 3: 2012-2014). RESULTS: Among 195 patients who underwent LLR, 24 (12...
December 13, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27933328/predictors-of-emesis-in-children-undergoing-procedural-sedation-with-intramuscular-ketamine-in-a-paediatric-emergency-department
#5
Shruthi Suryaprakash, Lai Peng Tham
INTRODUCTION: Emesis is one of the most common adverse events associated with ketamine sedation. However, the predictors of emesis have not been clearly studied among Asian children. This study aimed to determine the incidence and predictors of emesis in local children undergoing intramuscular (IM) ketamine sedation in the emergency department (ED), and identify high-risk groups(s), so that antiemetics may be administered prophylactically. METHODS: In a prospective observational study, all children requiring procedural sedation under IM ketamine in the paediatric ED between 1 April 2013 and 31 January 2015 were included...
December 9, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27933327/traumatic-diaphragmatic-injuries-a-retrospective-review-of-the-12-year-experience-at-a-tertiary-trauma-centre
#6
Beng Leong Lim, Li Tserng Teo, Ming Terk Chiu, Marxengel L Asinas-Tan, Eillyne Seow
INTRODUCTION: Traumatic diaphragmatic injuries (TDIs) are clinically challenging. We aimed to review TDIs treated at a tertiary trauma centre over a 12-year period. METHODS: This was a single-centre retrospective review of adult patients with TDIs treated between 1 January 2003 and 31 December 2014. Primary outcomes were mortality rates and Injury Severity Scores (ISS) associated with each TDI subtype. Secondary outcomes included proportions of TDIs diagnosed radiologically, operatively or during autopsy...
December 9, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27917434/what-factors-determine-the-need-for-lumbar-puncture-in-patients-with-fever-and-headache
#7
Ki Joong Kim, Jun Hwi Cho, Joong Bum Moon, Myoung Cheol Shin, Taek Geun Ohk, Hui Young Lee, Chan Woo Park
INTRODUCTION: We performed this study to search for clinical features and laboratory parameters that could facilitate the process of selection of patients who should receive lumbar punctures among those presenting with headache and fever. METHODS: We selected all patients aged ≥ 16 years who presented to and received lumbar puncture in the emergency department (ED) of Kangwon National University Hospital, South Korea, between 2011 and 2013. Patients who received a lumbar puncture were divided into two groups - patients diagnosed with viral meningitis and those that were not...
December 5, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27917433/deaths-among-elderly-patients-in-the-emergency-department-a-needs-assessment-for-end-of-life-care
#8
Rakhee Yash Pal, Win Sen Kuan, Yiwen Koh, Kuhan Venugopal, Irwani Ibrahim
INTRODUCTION: Elderly patients with serious chronic diseases often present to the emergency department (ED) in the last moments of their life, many with identifiable trajectories of dying: organ failure; advanced cancer; and chronic frailty. These patients and their families may benefit more from good end-of-life (EOL) care provision than the standard resuscitative approach. This study aimed to determine the incidence and nature of death among patients aged 65 years and above in an ED, and characterise their trajectories of dying...
December 5, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27868135/a-review-of-bioresorbable-scaffolds-hype-or-hope
#9
Huay Cheem Tan, Rajiv Ananthakrishna
The evolution of coronary metal stents has been well known for the past three decades, but it is only in the recent past that research on bioresorbable scaffolds has gained momentum in the field of percutaneous coronary intervention. Although second-generation drug-eluting metal stents are the gold standard for the treatment of obstructive coronary artery disease, a few drawbacks exist. The development of bioresorbable scaffolds is an attempt to overcome the limitations of metal stents. This review highlights the rationale for a bioresorbable scaffold, its properties and its potential application...
November 21, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27868134/developing-and-validating-a-localised-self-training-mindfulness-programme-for-older-singaporean-adults-effects-on-cognitive-functioning-and-implications-on-healthcare
#10
Bryan Wei Hoe Tam, Dana Rui Ting Lo, Daniel Wen Hao Seah, Jun Xian Lee, Zann Fang Ying Foo, Zoe Yu Yah Poh, Fionna Xiu Jun Thong, Sam Kim Yang Sim, Chew Sim Chee
There is relatively less research available on the effect of mindfulness on cognitive functioning. However, it has recently gained more attention due to the ageing population, as catalysed by recent findings on brain function and cellular ageing. Recognising the potential benefits of practicing mindfulness, we aimed to develop a localised, self-training mindfulness programme, guided by expert practitioners and usability testing, for older Singaporean adults. This was followed by a pilot study to examine the effects of this self-training programme on the cognitive functioning in older adults in Singapore...
November 21, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27995265/a-case-of-adult-submersion-injury-with-clinical-and-radiological-evidence-of-severe-brain-and-lung-injury-and-subsequent-complete-clinical-recovery
#11
Wen Jun Koh, Choon Peng Jeremy Wee, Duu Wen Sewa, Ting Hway Wong
No abstract text is available yet for this article.
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27995264/clinics-in-diagnostic-imaging-172-colocolic-intussusception-with-a-lipoma-as-the-lead-point
#12
Hsien Min Low, Dinesh Chinchure
A 50-year-old Chinese man presented with abdominal pain associated with bloody mucoid stools, loss of appetite and weight loss. Contrast-enhanced computed tomography of the abdomen and pelvis revealed a colocolic intussusception secondary to a lipoma. The patient subsequently underwent a left hemicolectomy. Clinical and imaging findings of intussusception in adults are discussed in this article.
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27995263/outpatient-management-of-transient-ischaemic-attack
#13
Victor Weng Keong Loh, Derek Tuck Loong Soon, Leonard Leong Litt Yeo
Stroke is a significant cause of death and disability in Singapore; in 2014, it was the fourth most common cause of death. Transient ischaemic attack (TIA) is defined as a transient episode of neurological dysfunction caused by focal brain, spinal cord or retinal ischaemia without evidence of acute infarction. The diagnosis of TIA/acute stroke needs to be considered in all patients who present with sudden focal neurological dysfunction. Prompt referral for assessment, neuroimaging and intervention provides the best chance for neurological recovery and/or minimising further neurological damage...
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27924349/juronghealth-research-and-quality-symposium-2016-in-conjunction-with-quality-month-2016-and-in-collaboration-with-allied-health-medical-and-nursing-i-s-e-e-i-study-i-experiment-i-evaluate-singapore-13-14-october-2016-proceedings-and-abstracts
#14
https://www.readbyqxmd.com/read/27570870/corticosteroid-injection-for-adhesive-capsulitis-in-primary-care-a-systematic-review-of-randomised-clinical-trials
#15
Kim Hwee Koh
Adhesive capsulitis is a common cause of shoulder pain and limited movement. The objectives of this review were to assess the efficacy and safety of corticosteroid injections for adhesive capsulitis and to evaluate the optimum dose and anatomical site of injections. PubMed and CENTRAL databases were searched for randomised trials and a total of ten trials were included. Results revealed that corticosteroid injection is superior to placebo and physiotherapy in the short-term (up to 12 weeks). There was no difference in outcomes between corticosteroid injection and oral nonsteroidal anti-inflammatory drugs at 24 weeks...
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26875682/early-outcome-of-transurethral-enucleation-and-resection-of-the-prostate-versus-transurethral-resection-of-the-prostate
#16
Sundaram Palaniappan, Tricia Li Chuen Kuo, Christopher Wai Sam Cheng, Keong Tatt Foo
INTRODUCTION: Recurrent prostate adenoma is a long-term complication following transurethral resection of the prostate (TURP). Transurethral enucleation and resection of the prostate (TUERP) is more appealing, since the nodular adenoma can be completely removed through endoscopy. TUERP is also hypothesised to result in a lower frequency of recurrent adenoma. This study aimed to compare the early outcomes of TUERP and TURP, and assess the feasibility and safety of TUERP. METHODS: We compared the outcome of 81 patients who underwent TUERP with that of 85 patients who underwent TURP...
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26843060/a-case-series-of-complicated-infective-otitis-media-requiring-surgery-in-adults
#17
Harold Heah, Sue Rene Soon, Heng-Wai Yuen
INTRODUCTION: With the advent of antibiotics, complications of otitis media have become less common. It is crucial for physicians to recognise otitis media and treat its complications early. Herein, we present our institution's experience with patients who required emergency surgical intervention for complications of otitis media. METHODS: Data on patients who underwent emergency surgery for complications of otitis media from 2004 to 2011 was retrieved from the archives of the Department of Otolaryngology, Changi General Hospital, Singapore...
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26805669/prevalence-of-asthma-like-symptoms-and-assessment-of-lung-function-in-schoolchildren-born-with-low-birth-weight
#18
Nik Zainal, Andy Rahardja, Che Yusoff Faris Irfan, Ariffin Nasir, Wan Ibrahim Wan Pauzi, Ilias Mohamad Ikram, Hans Van Rostenberghe
INTRODUCTION: This study aimed to determine the prevalence of asthma-like symptoms among schoolchildren with low birth weight (LBW), and to compare the lung function of these children with that of children with normal birth weight. METHODS: This was a comparative cross-sectional study. We recruited children aged 8-11 years from eight primary schools in Kota Bharu, Kelantan, Malaysia. The children were divided into two groups: those with LBW (< 2,500 g) and those with normal birth weight (≥ 2,500 g)...
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26805667/utility-of-cox1-phylogenetics-to-differentiate-between-locally-acquired-and-imported-plasmodium-knowlesi-infections-in-singapore
#19
Jin Phang Loh, Qiu Han Christine Gao, Vernon J Lee, Kevin Tetteh, Chris Drakeley
INTRODUCTION: Although there have been several phylogenetic studies on Plasmodium knowlesi (P. knowlesi), only cytochrome c oxidase subunit 1 (COX1) gene analysis has shown some geographical differentiation between the isolates of different countries. METHODS: Phylogenetic analysis of locally acquired P. knowlesi infections, based on circumsporozoite, small subunit ribosomal ribonucleic acid (SSU rRNA), merozoite surface protein 1 and COX1 gene targets, was performed...
December 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26778635/teaching-metacognition-in-clinical-decision-making-using-a-novel-mnemonic-checklist-an-exploratory-study
#20
Keng Sheng Chew, Steven J Durning, Jeroen Jg van Merriënboer
INTRODUCTION: Metacognition is a cognitive debiasing strategy that clinicians can use to deliberately detach themselves from the immediate context of a clinical decision, which allows them to reflect upon the thinking process. However, cognitive debiasing strategies are often most needed when the clinician cannot afford the time to use them. A mnemonic checklist known as TWED (T = threat, W = what else, E = evidence and D = dispositional factors) was recently created to facilitate metacognition...
December 2016: Singapore Medical Journal
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