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Singapore Medical Journal

Savas Sipahi, Ahmed Bilal Genc, Seyyid Bilal Acikgoz, Mehmet Yildirim, Yakup Ersel Aksoy, Mehmet Bulent Vatan, Hamad Dheir, Mustafa Altındis
INTRODUCTION: In patients undergoing haemodialysis, cardiovascular mortality and morbidity, characterised by accelerated atherosclerosis and increased inflammation, are elevated. Salusins are newly defined molecules in the atherosclerotic processes, and while salusin-alpha (Sal-α) acts as an antiatherogenic factor, salusin-beta (Sal-β) has a proatherogenic role. Their roles are as yet undefined in patients undergoing haemodialysis. METHODS: In this cross-sectional study, salusin levels, carotid intima-media thickness (CIMT) from the common carotid artery and pulse wave velocity (PWV) were measured for 180 patients undergoing haemodialysis and 90 healthy controls...
October 10, 2018: Singapore Medical Journal
Saleh Abdel-Kader, Massimo Sartelli, Fikri M Abu-Zidan
INTRODUCTION: The World Society of Emergency Surgery (WSES) has recently developed and validated a sepsis severity score for complicated intra-abdominal infections (cIAIs). We aimed to prospectively study the validity of this score in our local setting and compare it with global findings. METHODS: In a prospective study of 100 consecutive adult patients with cIAIs treated at Al-Ain Hospital, United Arab Emirates, from October 2014 to January 2016, we studied the demography of patients, disease, risk factors, WSES Sepsis Severity Score, management, hospital stay and mortality...
October 10, 2018: Singapore Medical Journal
Saleem Ahmed, Cristine Sl Ding, Vishal G Shelat
No abstract text is available yet for this article.
October 10, 2018: Singapore Medical Journal
Su Hooi Teo, Kian-Guan Lee, Gek Hsiang Lim, Si Xuan Koo, Maria Erika Ramirez, Khuan Yew Chow, Terence Kee
INTRODUCTION: Data on post-kidney transplantation (KTX) malignancy is limited in our region, leading to challenges in the care of renal allograft recipients. We aimed to examine the epidemiology, risk factors and outcomes of post-KTX patients. METHODS: A retrospective cohort study was conducted of 491 patients who underwent KTX from 1 January 2000 to 31 December 2011. Data linkage analysis was done between our centre and the National Registry of Disease Office to determine the standardised incidence ratio (SIR), standardised mortality ratio (SMR) and risk factors for malignancy after KTX...
October 10, 2018: Singapore Medical Journal
Amara Gul, Javed Yousaf
INTRODUCTION: Parkinson's disease (PD) is associated with cognitive decline but little is known about frontal-subcortical and posterior cortical cognitive functioning in patients with PD. The present study was designed to: (a) compare frontal and posterior cognitive functioning between patients with PD and healthy controls; (b) determine the effect of levodopa (L-dopa) on frontal-subcortical and posterior cortical cognitive functions; and (c) identify predictors of cognitive functions in patients with PD...
September 24, 2018: Singapore Medical Journal
Meng Zhu, Elvin Salioc Lokino, Cheri Su Hui Chan, Arlene Jeremie Gan, Ling Ling Ong, Kevin Boon Leong Lim
INTRODUCTION: Stable distal radius fractures in children are frequently treated by immobilisation with a cast and heal readily without complications. This randomised clinical trial aimed to assess patient satisfaction and casting-related clinical outcomes when using polyolefin cast, a new cast material, against conventional fibreglass cast. METHODS: A total of 80 patients, age range 7-16 years, with radiograph-confirmed stable distal radius fractures were recruited...
September 24, 2018: Singapore Medical Journal
Mingxiong Sheng, Lingling Wan, Changming Liu, Chunxiao Liu
INTRODUCTION: This study aims to assess whether cryosurgery is a feasible local therapy for bone metastatic prostate cancer (bmPCa). METHODS: A total of 23 patients with bmPCa who received cryosurgery and adjuvant androgen deprivation therapy (ADT) were included in the cryosurgery group (Group 1). Another 23 matched patients who received only ADT served as the control (Group 2). Prostate specific antigen (PSA) nadir level, time to PSA nadir, time to castration-resistant prostate cancer (CRPC), progression-free survival and therapy response of bone metastases were compared between the groups...
September 24, 2018: Singapore Medical Journal
Maxine Aiting Lam, Su Xian Lee, Kenneth Wei Jian Heng
INTRODUCTION: Knowledge of the pattern of alcohol-associated injury (AAI) is lacking in Singapore. We aimed to determine the local demographic pattern, injury mechanism, injury severity and outcomes of AAI. METHODS: Data on trauma cases presenting to emergency departments in 2012-2013 was extracted from the National Trauma Registry. Cases with missing data fields and ages 1-15 years were excluded. Patients were classified as alcohol positive (A+) or negative (A-) based on clinical assessment...
September 24, 2018: Singapore Medical Journal
Kah Wai Clarence Kwan, Teegan Reina Lim, Rajneesh Kumar, Thinesh Lee Krishnamoorthy
The increasing number of patients on the Singapore national liver transplant waiting list and the lack of donor livers have necessitated a review on the limited use of marginal donor liver grafts. Some grafts are of good quality but are considered marginal due to positive donor antibody to hepatitis B virus core protein serology, and negative hepatitis B surface antigen (HBsAg) and hepatitis B DNA. The fear is of viral reactivation during periods of intense immunosuppression. This is made possible by the ability of the hepatitis B virion to reside in a dormant state within the hepatocyte nucleus despite HBsAg clearance, i...
September 5, 2018: Singapore Medical Journal
Julian Sau Lian Chieng, Chau Hung Lee, Amit Anand Karandikar, Julian Park Nam Goh, Susanna Soo See Tan
INTRODUCTION: Thyroid fine-needle aspiration cytology (FNAC) is an established investigation for the preoperative evaluation of thyroid nodules and is often done under ultrasonography guidance. While its accuracy has been widely reported, there is little evidence in the literature on the approach to non-diagnostic cytology results. In our study, we aimed to determine the diagnostic performance of ultrasonography-guided thyroid FNAC for the preoperative diagnosis of thyroid cancer at our institution and evaluate the significance of a non-diagnostic thyroid FNAC...
September 5, 2018: Singapore Medical Journal
Sumanth Kumar Gera, D K Halimatussadiah PG Zaini, Shiyao Wang, Siti Hauzah Binte Abdul Rahaman, Rui Fang Chia, Kevin Boon Leong Lim
INTRODUCTION: Ingrowing toenail (IGTN) or onychocryptosis is not uncommon in children and adolescents. However, there is a dearth of evidence in the literature on the management of IGTN in this age group. This study aimed to compare the results of nonoperative treatment for IGTN with that of operative treatment among children and adolescents. METHODS: All children and adolescents who were treated for IGTN at our institution between 2010 and 2014 were included for this retrospective study...
September 5, 2018: Singapore Medical Journal
Ru Xin Wong, Hui Ying Terese Low, Daniel Yat Harn Tan
INTRODUCTION: There are many treatment options for vestibular schwannomas (VS), including radiosurgery. Previous studies have shown good outcomes for smaller tumours. We report the results of a seven-year cohort of patients with VS who were treated at our centre using a linear accelerator-based stereotactic radiosurgery system. METHODS: We retrospectively reviewed the case notes and magnetic resonance (MR) images of patients with VS treated with radiosurgery. Treatment was administered as either a single 13 Gy session or 25 Gy in five sessions...
September 5, 2018: Singapore Medical Journal
Shaji Jose Vadassery, Keng He Kong, Wai Mun Lorraine Ho, Aruni Seneviratna
INTRODUCTION: The Functional Independence Measure (FIM) is a validated, objective assessment of functional status. Though widely used in rehabilitation centres, it may not be practical for all patients due to time and/or personnel constraints. Studies show positive and negative agreements on self-reported FIM scores for patients with spinal cord injuries and amputees. We tested the validity of the self-reported FIM motor score among stroke patients. METHODS: In a prospective, double-blinded comparative study of patient self-reporting against multidisciplinary assessment, using the standard FIM algorithm, all eligible stroke patients (n = 47) admitted to our rehabilitation centre were included...
September 5, 2018: Singapore Medical Journal
Jieli Tong, Quek Wei Yong
No abstract text is available yet for this article.
August 21, 2018: Singapore Medical Journal
Hany Ariffin, Kee Seang Chew, Vida Jawin, Surendran Thavagnanam
No abstract text is available yet for this article.
August 21, 2018: Singapore Medical Journal
Edgar Lik Wui Tay, Jinghao Nicholas Ngiam, William Kf Kong, Kian-Keong Poh
No abstract text is available yet for this article.
August 21, 2018: Singapore Medical Journal
Donald Th Tan
No abstract text is available yet for this article.
September 2018: Singapore Medical Journal
Anselm Chi-Wai Lee
No abstract text is available yet for this article.
September 2018: Singapore Medical Journal
Mark Christopher Pearce, Garry Choy, Robert Chun Chen
A 54-year-old man presented with progressive onset of lower limb paraesthesias, sensory ataxia, gait instability and lower limb weakness. Laboratory findings revealed low serum B12 levels. Magnetic resonance imaging showed long-segment symmetrically increased T2 signal within the dorsal columns of the spinal cord in the lower thoracic spine. The conglomeration of findings was consistent with a diagnosis of subacute combined degeneration of the spinal cord (SCD). Aside from mild residual paraesthesias, the patient's symptoms largely resolved after treatment with intramuscular injections of vitamin B12...
September 2018: Singapore Medical Journal
Anselm Chi-Wai Lee, LeLe Aung, Yeng Yoong Yip, Cindy Ping-Ping Hia
No abstract text is available yet for this article.
September 2018: Singapore Medical Journal
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