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Singapore Medical Journal

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https://www.readbyqxmd.com/read/28210748/risk-factors-associated-with-abdominal-obesity-in-suburban-adolescents-from-a-malaysian-district
#1
Wai Fong Chew, Pooi Pooi Leong, Sook Fan Yap, A Malik Yasmin, Kong Bung Choo, Gary Kim Kuan Low, Nem Yun Boo
INTRODUCTION: We aimed to determine the risk factors associated with abdominal obesity (AO) in suburban adolescents. METHODS: This cross-sectional study included adolescents aged 15-17 years from five randomly selected secondary schools in the Hulu Langat district of Selangor State, Malaysia. Waist circumference (WC) was measured at the midpoint between the lower margin of last palpable rib and the top of iliac crest. Information on sociodemographic data, dietary habits, physical activity levels and duration of sleep was obtained via interviewer-administered questionnaires...
February 17, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210747/extent-of-field-change-in-colorectal-cancers-with-braf-mutation
#2
Aaron Poh, Heidi Sian Ying Chang, Kok Yang Tan, Xin Xiu Sam, Avery Khoo, Shoa Nian Choo, Min En Nga, Wei Keat Wan
INTRODUCTION: Sporadic colorectal cancers with BRAF mutations constitute two distinct subgroups of colorectal cancers. Recent studies have linked the presence of the BRAF mutation to a familial inheritance pattern. This was a proof-of-concept study that aimed to examine: (a) the extent of field change in sporadic colorectal cancers with BRAF mutation; and (b) the extent of resection margins required and the pattern of DNA mismatch repair protein loss in these tumours. METHODS: Eight microsatellite instability-high (MSI-H) tumours with positive BRAF mutation from an existing histopathological database were selected for BRAF mutation and mismatch repair protein analysis...
February 17, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/27995262/ethyl-pyruvate-has-anti-apoptotic-and-myocardial-protective-effects-after-regional-ischaemia-reperfusion-myocardial-damage-in-an-in-vivo-rat-model
#3
Haeng Seon Shim, Jeong Heon Park, Yeon A Kim, Jeong Yeol Han, Miyeong Park, Yun Gyu Song, Joon Soo Kim, Il-Woo Shin
INTRODUCTION: The integration of reactive oxygen species is strongly associated with important pathophysiological mechanisms that mediate myocardial ischaemia/reperfusion (I/R) damage. Pyruvate is an efficacious scavenger of reactive oxygen species and a previous study has shown that ethyl pyruvate (EP) has a myocardial protective effect against regional I/R damage in an in vivo rat model. The purpose of this study was to determine whether the myocardial protective effect of EP is associated with anti-apoptosis...
December 20, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27995261/interval-increase-in-the-prevalence-of-symptomatic-cholelithiasis-associated-non-alcoholic-fatty-liver-disease-over-a-ten-year-period-in-an-asian-population
#4
Kevin Beng Chin Khaw, Rachel Huiyi Choi, Juinn Huar Kam, Bibhas Chakraborty, Pierce Kah Hoe Chow
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is frequently associated with cholelithiasis. The prevalence of NAFLD has been on the rise in Asia, but the magnitude of this increase has not been previously studied. METHODS: A retrospective cohort study was carried out on consecutive patients who underwent laparoscopic or open cholecystectomy from November 2001 to November 2004 (cohort 1) and from November 2011 to November 2014 (cohort 2) at Singapore General Hospital...
December 20, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27957585/coronary-artery-calcium-score-and-coronary-computed-tomography-angiography-for-patients-with-asymptomatic-polyvascular-non-coronary-atherosclerosis
#5
Annagrazia Cecere, Graziano Riccioni, Nicola Sforza, Riccardo Marano, Giuseppe Guglielmi
INTRODUCTION: The primary endpoint of this study was to determine the prevalence of coronary artery disease (CAD) and coronary artery calcium score (CACS) using coronary computed tomography angiography (CCTA) among patients with polyvascular atherosclerosis (PVA). Secondary endpoints were to evaluate the prevalence of cardiovascular risk factors and determine the predictors of PVA. METHODS: The presence of atherosclerotic disease was assessed using ultrasonographic vascular examination in 515 asymptomatic patients...
December 13, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27957584/evolution-of-laparoscopic-liver-resection-at-singapore-general-hospital-a-nine-year-experience-of-195-consecutive-resections
#6
Brian Kp Goh, Jin-Yao Teo, Chung-Yip Chan, Ser-Yee Lee, Peng-Chung Cheow, Pierce Kh Chow, London Lpj Ooi, Alexander Yf Chung
INTRODUCTION: We aimed to analyse the changing trends, safety and outcomes associated with the adoption of laparoscopic liver resection (LLR) at a single centre. METHODS: A retrospective review was carried out of 195 patients who underwent LLR from 2006 to 2014 at our institution. To explore the evolution of LLR, the study was divided into three equal consecutive time periods (period 1: 2006-2008; period 2: 2009-2011; and period 3: 2012-2014). RESULTS: Among 195 patients who underwent LLR, 24 (12...
December 13, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27933328/predictors-of-emesis-in-children-undergoing-procedural-sedation-with-intramuscular-ketamine-in-a-paediatric-emergency-department
#7
Shruthi Suryaprakash, Lai Peng Tham
INTRODUCTION: Emesis is one of the most common adverse events associated with ketamine sedation. However, the predictors of emesis have not been clearly studied among Asian children. This study aimed to determine the incidence and predictors of emesis in local children undergoing intramuscular (IM) ketamine sedation in the emergency department (ED), and identify high-risk groups(s), so that antiemetics may be administered prophylactically. METHODS: In a prospective observational study, all children requiring procedural sedation under IM ketamine in the paediatric ED between 1 April 2013 and 31 January 2015 were included...
December 9, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27933327/traumatic-diaphragmatic-injuries-a-retrospective-review-of-the-12-year-experience-at-a-tertiary-trauma-centre
#8
Beng Leong Lim, Li Tserng Teo, Ming Terk Chiu, Marxengel L Asinas-Tan, Eillyne Seow
INTRODUCTION: Traumatic diaphragmatic injuries (TDIs) are clinically challenging. We aimed to review TDIs treated at a tertiary trauma centre over a 12-year period. METHODS: This was a single-centre retrospective review of adult patients with TDIs treated between 1 January 2003 and 31 December 2014. Primary outcomes were mortality rates and Injury Severity Scores (ISS) associated with each TDI subtype. Secondary outcomes included proportions of TDIs diagnosed radiologically, operatively or during autopsy...
December 9, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27917434/what-factors-determine-the-need-for-lumbar-puncture-in-patients-with-fever-and-headache
#9
Ki Joong Kim, Jun Hwi Cho, Joong Bum Moon, Myoung Cheol Shin, Taek Geun Ohk, Hui Young Lee, Chan Woo Park
INTRODUCTION: We performed this study to search for clinical features and laboratory parameters that could facilitate the process of selection of patients who should receive lumbar punctures among those presenting with headache and fever. METHODS: We selected all patients aged ≥ 16 years who presented to and received lumbar puncture in the emergency department (ED) of Kangwon National University Hospital, South Korea, between 2011 and 2013. Patients who received a lumbar puncture were divided into two groups - patients diagnosed with viral meningitis and those that were not...
December 5, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27917433/deaths-among-elderly-patients-in-the-emergency-department-a-needs-assessment-for-end-of-life-care
#10
Rakhee Yash Pal, Win Sen Kuan, Yiwen Koh, Kuhan Venugopal, Irwani Ibrahim
INTRODUCTION: Elderly patients with serious chronic diseases often present to the emergency department (ED) in the last moments of their life, many with identifiable trajectories of dying: organ failure; advanced cancer; and chronic frailty. These patients and their families may benefit more from good end-of-life (EOL) care provision than the standard resuscitative approach. This study aimed to determine the incidence and nature of death among patients aged 65 years and above in an ED, and characterise their trajectories of dying...
December 5, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210746/increased-neutrophil-to-lymphocyte-ratio-is-it-really-diagnostic-of-restless-legs-syndrome
#11
Mustafa Afifi
No abstract text is available yet for this article.
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210745/spontaneous-coronary-artery-dissection
#12
Alexander Dashwood, Selvanayagam Niranjan, Saheb Al-Daher, Jerome Goldstein
No abstract text is available yet for this article.
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210744/comment-on-zika-in-singapore-insights-from-one-health-and-social-medicine
#13
John H Lange, Luca Cegolon
No abstract text is available yet for this article.
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210743/authors-reply
#14
Tamra Lysaght, Zohar Lederman, Paul Anantharajah Tambyah
No abstract text is available yet for this article.
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210742/clinics-in-diagnostic-imaging-174-l5-vertebral-superior-facet-osteoblastoma-ob
#15
Manickam Subramanian, Hong Chou, Kabilan Chokkappan, Wilfred Cg Peh
A 25-year-old man presented with chronic low back pain and occasional radiation to the right lower limb. Magnetic resonance imaging and computed tomography (CT) of the lumbar spine showed an osteolytic expansile lesion with a central sclerotic nidus in the right superior facet of the L5 vertebra and surrounding marrow oedema. The diagnosis of osteoblastoma was made based on imaging findings and confirmed after CT-guided biopsy. Radiofrequency ablation of the lesion was successfully performed. The patient tolerated the procedure well and showed symptomatic relief...
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210741/depression-in-primary-care-assessing-suicide-risk
#16
Chung Wai Mark Ng, Choon How How, Yin Ping Ng
Major depression is a common condition seen in the primary care setting. This article describes the suicide risk assessment of a depressed patient, including practical aspects of history-taking, consideration of factors in deciding if a patient requires immediate transfer for inpatient care and measures to be taken if the patient is not hospitalised. It follows on our earlier article about the approach to management of depression in primary care.
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/27609508/the-singapore-myeloma-study-group-consensus-guidelines-for-the-management-of-patients-with-multiple-myeloma
#17
Sanjay de Mel, Yunxin Chen, Sathish Kumar Gopalakrishnan, Melissa Ooi, Constance Teo, Daryl Tan, Min Li Claire Teo, Allison Cy Tso, Lian King Lee, Chandramouli Nagarajan, Yeow Tee Goh, Wee Joo Chng
Multiple myeloma (MM) is an incurable plasma cell neoplasm with an incidence of 100 patients per year in Singapore. Major advances have been made in the diagnosis, risk stratification and treatment of MM in the recent past. The reclassification of a subset of patients with smouldering MM, based on high-risk biomarkers, and the development of the revised international staging system are among the key new developments in diagnosis and staging. The use of novel agent-based treatment has resulted in significant improvements in the survival and quality of life of many patients with MM...
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/27526703/how-effective-is-acupuncture-for-reducing-pain-due-to-plantar-fasciitis
#18
Anandan Gerard Thiagarajah
INTRODUCTION: Plantar fasciitis is a commonly seen outpatient condition that has numerous treatment modalities of varying degrees of efficacy. This systematic review aimed to determine the effectiveness of acupuncture in reducing pain caused by plantar fasciitis. METHODS: Online literature searches were performed on the PubMed and Cochrane Library databases for studies on the use of acupuncture for pain caused by plantar fasciitis. Studies designed as randomised controlled trials and that compared acupuncture with standard treatments or had real versus sham acupuncture arms were selected...
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/26976222/radiological-analysis-of-the-medial-epicondyle-in-the-adolescent-throwing-athlete
#19
Wuey Min Ng, Chee Ken Chan, Norimasa Takahashi, Nobuaki Kawai, Kok Kheng Teh, R Saravana, Hiroyuki Sugaya
INTRODUCTION: Injuries to the medial structures of the elbow due to overhead throwing games are well documented. However, variations of medial epicondyles are not well described, especially in athletes with fused medial epicondyles. In this study, we evaluated variations in the medial epicondyle of baseball players who were aged 15-17 years and had fused epicondyles. METHODS: In this cross-sectional observational study, 155 skeletally mature baseball players with unilateral medial elbow pain and 310 elbow radiographs were reviewed by two independent reviewers...
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/26948107/the-long-and-short-of-cephalomedullary-nails-in-the-treatment-of-osteoporotic-pertrochanteric-fracture
#20
Choon Chiet Hong, Nazrul Nashi, Milindu Chanaka Makandura, Jiong Hao Jonathan Tan, Luke Peter, Diarmuid Murphy
INTRODUCTION: Pertrochanteric fractures after low-energy trauma are common among osteoporotic patients. Although the use of intramedullary devices to treat such fractures is becoming increasingly popular, there is a paucity of data comparing the outcomes of the use of short cephalomedullary nails (SCN) with the use of long cephalomedullary nails (LCN). This study aimed to compare the outcomes of treatment using LCN with treatment using SCN for patients with osteoporotic pertrochanteric fractures...
February 2017: Singapore Medical Journal
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