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Scandinavian Journal of Clinical and Laboratory Investigation

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https://www.readbyqxmd.com/read/29226724/standardization-of-clinical-enzyme-analysis-using-frozen-human-serum-pools-with-values-assigned-by-the-international-federation-of-clinical-chemistry-and-laboratory-medicine-reference-measurement-procedures
#1
Qing Tong, Baorong Chen, Rui Zhang, Chang Zuo
Variation in clinical enzyme analysis, particularly across different measuring systems and laboratories, represents a critical but long-lasting problem in diagnosis. Calibrators with traceability and commutability are imminently needed to harmonize analysis in laboratory medicine. Fresh frozen human serum pools were assigned values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), creatine kinase (CK) and lactate dehydrogenase (LDH) by six laboratories with established International Federation of Clinical Chemistry and Laboratory Medicine reference measurement procedures...
December 9, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29199452/semaphorin-3a-and-netrin-1-predict-the-development-of-kidney-injury-in-children-with-congenital-hydronephrosis
#2
Xiaobing Li, Xianghua Liu, Ji Li, ELi Song, Ning Sun, Wen Liu, Tian Wang, Jinchang Yang, Zhenzhen Li
Congenital obstructive nephropathy is amongst the main causes of chronic renal failure in children. Early diagnosis and initiation of the treatment will delay progressive renal tubular atrophy and interstitial fibrosis with the loss of nephrons. The aim of this study was to evaluate whether urinary (u) semaphorin-3A (SEMA-3A) and Netrin-1 may be potential biomarkers in children with congenital hydronephrosis due to ureteropelvic junction obstruction (UPJO). The study consisted of 42 children with severe hydronephrosis who needed surgery and two control groups (Control One: 42 children with mild, non-obstructive hydronephrosis; Control Two: 44 healthy children)...
December 3, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29199450/validity-of-two-poct-glucose-measurement-devices-in-hypoglycaemia-how-reliable-is-my-result
#3
Rolf Bikker, Denis Grote-Koska, Petra Domberg, Korbinian Brand
No abstract text is available yet for this article.
December 3, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29186997/western-diets-are-not-responsible-for-chronic-acid-retention-a-critical-analysis-of-organic-acid-and-phosphate-contribution
#4
Roberto Mioni, Giuseppe Mioni
According to usual literature, the diet-dependent endogenous production of titratable acidity (TA) is contributed by sulphuric and phosphoric acids (NA) and by metabolizable acids (MAs), representing 'net-endogenous acid production' (NEAP). NEAP is mainly neutralised by diet-dependent [Formula: see text] salts of inorganic cations ([Formula: see text]), estimated in foods, faeces and urine from inorganic cation-anion difference (NB). It is claimed that urinary loss of organic acids' anions, '[Formula: see text]', induces metabolizable H+ ions' retention...
November 29, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29179592/elevated-plasma-procalcitonin-level-predicts-poor-prognosis-of-st-elevation-myocardial-infarction-in-asian-elderly
#5
Junru Dai, Bangbo Xia, Xiaomiao Wu
Previous studies have focused on relationship between plasma procalcitonin level and myocardial infarction risk, but this relationship in Asian elderly has not been investigated. The aim of this study was to reveal the association of peripheral procalcitonin concentration (both immediate and average levels) with myocardial infarction prognosis in Asian elderly. A total of 400 ST-elevation myocardial infarction patients, 400 unstable angina patients and 400 controls were included. Plasma levels of high-sensitivity C-reactive protein and procalcitonin were measured using commercially available kits...
November 27, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29168398/paraoxonase-arylesterase-and-lactonase-activities-of-paraoxonase-1-pon1-in-obese-and-severely-obese-women
#6
Carlo Cervellati, Gloria Bonaccorsi, Alessandro Trentini, Giuseppe Valacchi, Juana M Sanz, Monica Squerzanti, Manuela Spagnolo, Leo Massari, Ilaria Crivellari, Pantaleo Greco, Roberta Parladori, Angelina Passaro, Giorgio Ricci
Obesity is independently associated with disturbances in lipid and lipoprotein metabolism, oxidative stress, and is a well-established independent risk factor for cardiovascular diseases (CVD). Human paraoxonase 1 (PON1) is a pleotropic high-density lipoprotein (HDL)-associated enzyme with antioxidant and anti-inflammatory proprieties that have been suggested to contribute to the athero-protective function of the lipoprotein. The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL cholesterol (HDL-C) concentration...
November 23, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29157015/influence-of-selected-antithrombotic-treatment-on-thromboelastometric-results
#7
Mia Hammer Holck, Thomas Decker Christensen, Anne-Mette Hvas
Rotatory thromboelastometry (ROTEM(®)) is used for diagnosing and monitoring bleeding patients. Some of these patients receive antithrombotic treatment, thus having an increased risk of bleeding. Only sparse knowledge exists about whether the ROTEM(®) analysis is influenced by antithrombotic treatment. The objective of the present study was to examine if the ROTEM(®) results are affected in patients receiving antithrombotic treatment. This prospective observational study included patients receiving either vitamin K-antagonists (VKA), aspirin (ASA) or ASA combined with an adenosine diphosphate (ADP) receptor antagonist (ASA + ADP)...
November 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29148292/cholestatic-liver-injury-as-a-side-effect-of-dabigatran-and-the-use-of-coagulation-tests-in-dabigatran-intoxication-and-after-reversal-by-idarucizumab-in-bleeding-and-sepsis
#8
Willemijn J Comuth, Anne-Mette Haase, Linda Ø Henriksen, Jerzy Malczynski, Daan van de Kerkhof, Anna-Marie B Münster
Idarucizumab, an antidote specific for dabigatran, became available recently. Dabigatran is not associated with increased risk of hepatotoxicity in comparison with warfarin, but it is seen as a rare side-effect. Cases of cholestatic liver injury due to dabigatran have not been reported previously. We present a case of severe gastro-intestinal bleeding with underlying dabigatran intoxication in a patient with renal failure and the effect of reversal of dabigatran using idaruzicumab on coagulation assays. International normalized ratio (INR) and activated partial thromboplastin time (APTT) results were elevated in a setting of sepsis, possibly due to liver failure...
November 17, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29141453/relationship-between-metabolic-syndrome-and-nodular-thyroid-diseases
#9
Seher Kir, Yusuf Aydin, Hulya Coskun
Nodular thyroid diseases are common in Turkey. Insulin resistance (IR) is considered as the most important component of metabolic syndrome (MetS), and it is thought to directly affect thyroid diseases, together with other components of MetS. The aim of this study was to evaluate potential factors associated with thyroid nodularity. This study was part of the prospective MELEN study. In total, randomly selected 2233 subjects were evaluated. A euthyroid subgroup of participants (n = 1432) was selected and 421 of them had MetS...
November 16, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29141445/measurement-of-dabigatran-previously-demonstrated-hemoclot-%C3%A2-thrombin-inhibitor-assay-reagent-instability-on-sysmex-cs-2100i-is-no-longer-an-issue
#10
Willemijn J Comuth, Louise Faaborg, Linda Ø Henriksen, Anna-Marie B Münster
The Hemoclot(®) Thrombin Inhibitor (HTI) assay has been recommended for measurement of dabigatran concentrations in specific clinical situations. Traditionally, reagents for biochemical assays are prepared from instructions found in the package insert. For the HTI reagents the manufacturer recommends incubating the reagents much longer than indicated in the package insert. These recommendations are added to the application sheets designed for different analyzers. Many clinicians and laboratory personnel may be unaware of the discrepancy between the two instructions, resulting in incorrect handling of the reagents...
November 16, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29117724/reference-intervals-for-absolute-and-percentage-immature-platelet-fraction-using-the-sysmex-xn-10-automated-haematology-analyser-in-a-uk-population
#11
Usman Ali, Gavin Knight, Roz Gibbs, Dimitris A Tsitsikas
BACKGROUND: Immature platelet fraction (IPF) estimation is a non-invasive and sensitive test that is available on recently introduced Sysmex XN-series of automated haematology analysers. It is a direct cellular indicator of thrombopoiesis. The aim of this study was to establish reference intervals for IPF, for both absolute (A-IPF) and percentage (%-IPF) measurements. MATERIAL AND METHODS: A total of 2366 samples that met the inclusion criteria were assayed for full blood count on the Sysmex XN-10 and a non-parametric percentile method was used for calculating the reference intervals...
November 9, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29103322/prehypertension-and-high-serum-uric-acid-increase-risk-of-arterial-stiffness
#12
Piyanuch Thitiwuthikiat, Duangduan Siriwittayawan, Teonchit Nuamchit
Prehypertension and serum uric acid are emerging as independent risk factors for arterial stiffness and may also predict cardiovascular diseases. Previous studies have demonstrated the association between serum uric acid and arterial stiffness in hypertensive adults, but there are limited studies in prehypertensive adults. We compared the serum uric acid (SUA) and cardio-ankle vascular index (CAVI) between normotensive and prehypertensive participants. The association between SUA, prehypertension and CAVI were investigated...
November 6, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29103321/improved-assessment-of-arterial-stiffness-using-corrected-cardio-ankle-vascular-index-cavi0-in-overweight-adolescents-with-white-coat-and-essential-hypertension
#13
Michal Mestanik, Alexander Jurko, Bart Spronck, Alberto P Avolio, Mark Butlin, Tomas Jurko, Zuzana Visnovcova, Andrea Mestanikova, Peter Langer, Ingrid Tonhajzerova
Arterial stiffness is a marker of vascular damage. Although adiposity increases cardiovascular risk, the relationship between paediatric overweight and arterial stiffness is unclear. The study aimed to evaluate the simultaneous effect of hypertension and overweight on arterial stiffness using cardio-ankle vascular index (CAVI) and related novel, theoretically blood pressure (BP)-independent, index CAVI0. CAVI and CAVI0 were measured in 140 adolescent boys (16.0 ± 1.9 years) divided into age-matched groups: normal-weight normotensives, overweight normotensives, overweight white-coat hypertensives, and overweight essential hypertensives...
November 6, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29081243/evaluation-of-between-within-and-day-to-day-variation-of-coagulation-measured-by-rotational-thrombelastometry-rotem
#14
Petra Jilma-Stohlawetz, Susanne Fritsche-Polanz, Peter Quehenberger, Christian Schörgenhofer, Johann Bartko, Robin Ristl, Bernd Jilma
BACKGROUND AND AIMS: The aim of this study was to assess the circadian variation and the between- and within-subject variation in 10 healthy subjects over a period of 8 weeks by ROTEM(®). We further evaluated the influence of elevated body mass index and the effect of low molecular weight heparin and antithrombin on clot formation. METHODS: Citrated blood samples were analysed in the NATEM(®) test system. The clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF) and the maximum lysis (ML) were assessed...
October 28, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29069989/high-first-trimester-maternal-blood-cystatin-c-levels-despite-normal-serum-creatinine-predict-pre-eclampsia-in-singleton-pregnancies
#15
Martin Risch, Mette-Triin Purde, Marc Baumann, Markus Mohaupt, Beatrice Mosimann, Harald Renz, Luigi Raio, Daniel Surbek, Lorenz Risch
Early biochemical identification of women at high risk for the development of pre-eclampsia (PE) is still unsatisfactory. Renal markers measured during the first trimester were analysed to predict later occurrence of PE. A nested case-control study was conducted within the prospective predictive markers for the diagnosis of preeclampsia study. Pregnant women were included at the end of the first trimester and followed up until birth. Controls were matched to PE cases. Renal markers [i.e. creatinine, cystatin C (CysC), β2 microglobulin (B2M), β-trace protein (BTP), glomerular filtration rate estimations (eGFR) of the aforementioned markers, uric acid (UA), urea, and serum uromodulin (sUMOD)] were compared to placental growth factor (PlGF), a marker known to predict PE later in pregnancy...
December 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29069923/comparison-of-two-assays-measuring-human-chorionic-gonadotrophin-serum-concentrations-in-pregnancy-termination-and-trophoblastic-or-non-trophoblastic-tumours
#16
Fleur Wolff, Christine Gervy, Béatrice Gulbis, Frédéric Cotton
BACKGROUND: Differences in human chorionic gonadotrophin (hCG) results provided by the commercial immunoassays reflect the heterogeneity of antibodies and the use of suboptimal standards. As a consequence, the principal forms of hCG and metabolites are differentially detected and the hCG tests are not suited for the same clinical applications. Conflicting results are available in the literature regarding which hCG variants are recognized by the Roche Elecsys hCG + β test. The aim of our study was to compare the hCG concentrations provided by the Siemens Immulite 2000 test and the Roche test as well as to assess the concordance between both assays...
October 25, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29069917/the-association-between-serological-features-of-chronic-chlamydia-pneumoniae-infection-and-markers-of-systemic-inflammation-and-nutrition-in-copd-patients
#17
Magdalena Paplińska-Goryca, Renata Rubinsztajn, Patrycja Nejman-Gryz, Tadeusz Przybyłowski, Rafał Krenke, Ryszarda Chazan
INTRODUCTION: Chlamydia pneumoniae is an obligatory human pathogen involved in lower and upper airway infections, including pneumonia, bronchitis. Asymptomatic C. pneumoniae carriage is also relatively common. The association of C. pneumoniae infections with the chronic obstructive pulmonary disease (COPD) course is unclear. OBJECTIVES: The aim of the study was to investigate the association between chronic C. pneumoniae infection and clinical features of COPD, markers of inflammation and metabolic dysfunction...
October 25, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29043850/age-adjusted-d-dimer-cut-off-in-the-diagnostic-strategy-for-deep-vein-thrombosis-a-systematic-review
#18
Mads Nybo, Anne-Mette Hvas
BACKGROUND: Studies have indicated that use of an age-adjusted D-dimer cut-off value for patients above 50 years increases utility of the diagnostic strategy for pulmonary embolism. Evidence for the same approach regarding diagnosis of deep vein thrombosis (DVT) is, however, unclear. MATERIALS AND METHODS: A systematic literature review was conducted following the PRISMA Statement guideline to gather the existing knowledge on the use of an age-adjusted D-dimer cut-off in the diagnostic strategy for DVT...
October 18, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29043840/comparison-of-two-methods-based-on-photoplethysmography-for-the-diagnosis-of-peripheral-arterial-disease
#19
Christian Høyer, Nikolaj Schandorph Nielsen, Malene Kragh Overvad Jordansen, Helle Damgaard Zacho
AIM: To examine the interchangeability of two methods for distal pressure measurement based on photoplethysmography using a truncated or full display of the arterial inflow curve, respectively. METHODS: Toe and ankle pressures were obtained from 69 patients suspected of peripheral arterial disease (PAD). Observer reproducibility of the curve readings was examined by blinded reassessment of the pressure curves in a randomly selected subgroup (60 limbs). RESULTS: There were no significant differences in mean pressures between the two methods (p for all > ...
October 18, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29037082/the-d313y-variant-in-the-gla-gene-no-evidence-of-a-pathogenic-role-in-fabry-disease
#20
Lis Hasholt, Martin Ballegaard, Henning Bundgaard, Michael Christiansen, Ian Law, Allan M Lund, Anne Norremolle, Ase Krogh Rasmussen, Kirstine Ravn, Zeynep Tumer, Flemming Wibrand, Ulla Feldt-Rasmussen
Fabry disease is an X- linked inherited lysosomal storage disease caused by mutations in the GLA gene encoding the lysosomal enzyme alpha-galactosidase A (α-Gal A). The possible pathological significance of the D313Y variant in the GLA gene has not been verified and it may be a Fabry variant. Our aim was to elucidate whether the presence of the D313Y variant influenced the α-Gal A activity or resulted in Fabry symptoms or Fabry organ involvement. In two Danish families the presence of the D313Y variant did not result in reduced α-Gal A activity or clinical Fabry manifestations in males, and the presence in Fabry females did not significantly enhance the phenotype of a known causative mutation in the GLA gene (G271S)...
October 16, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
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