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Journal of Nutrition

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https://www.readbyqxmd.com/read/28202639/dietary-protein-intake-in-young-children-in-selected-low-income-countries-is-generally-adequate-in-relation-to-estimated-requirements-for-healthy-children-except-when-complementary-food-intake-is-low
#1
Joanne E Arsenault, Kenneth H Brown
Background: Previous research indicates that young children in low-income countries (LICs) generally consume greater amounts of protein than published estimates of protein requirements, but this research did not account for protein quality based on the mix of amino acids and the digestibility of ingested protein.Objective: Our objective was to estimate the prevalence of inadequate protein and amino acid intake by young children in LICs, accounting for protein quality.Methods: Seven data sets with information on dietary intake for children (6-35 mo of age) from 6 LICs (Peru, Guatemala, Ecuador, Bangladesh, Uganda, and Zambia) were reanalyzed to estimate protein and amino acid intake and assess adequacy...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28202638/vitamin-concentrations-in-human-milk-vary-with-time-within-feed-circadian-rhythm-and-single-dose-supplementation
#2
Daniela Hampel, Setareh Shahab-Ferdows, M Munirul Islam, Janet M Peerson, Lindsay H Allen
Background: Human milk is the subject of many studies, but procedures for representative sample collection have not been established. Our improved methods for milk micronutrient analysis now enable systematic study of factors that affect its concentrations.Objective: We evaluated the effects of sample collection protocols, variations in circadian rhythms, subject variability, and acute maternal micronutrient supplementation on milk vitamin concentrations.Methods: In the BMQ (Breast-Milk-Quality) study, we recruited 18 healthy women (aged 18-26 y) in Dhaka, Bangladesh, at 2-4 mo of lactation for a 3-d supplementation study...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28202637/supplemental-selenium-may-decrease-ovarian-cancer-risk-in-african-american-women
#3
Paul D Terry, Bo Qin, Fabian Camacho, Patricia G Moorman, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Kristin A Guertin, Edward S Peters, Ann G Schwartz, Joellen M Schildkraut, Elisa V Bandera
Background: To our knowledge, no previous study has evaluated the associations of antioxidant intake with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease.Objective: We sought to evaluate these associations among 406 ovarian cancer cases and 632 age- and site-matched controls of African-American descent recruited from AACES (African American Cancer Epidemiology Study), a population-based, case-control study in 11 geographical areas within the United States...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28202636/moderate-to-severe-iodine-deficiency-in-the-first-1000-days-causes-more-thyroid-hypofunction-in-infants-than-in-pregnant-or-lactating-women
#4
Sara Stinca, Maria Andersson, Isabelle Herter-Aeberli, Laila Chabaa, Mohamed Cherkaoui, Nawal El Ansari, Abdelmounaim Aboussad, Sandra Weibel, Michael B Zimmermann
Background: Iodine deficiency early in the life cycle-the "first 1000 days"-can cause hypothyroidism and irreversibly impair neuromotor development. However, the relative vulnerability among women and infants during this critical period is unclear, making it difficult for country-based programs with limited resources to prioritize their iodine interventions.Objective: Our aim was to determine the prevalence of thyroid hypofunction in women and infants living in an area of moderate-to-severe iodine deficiency...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28202635/short-term-subclinical-zinc-deficiency-in-weaned-piglets-affects-cardiac-redox-metabolism-and-zinc-concentration
#5
Daniel Brugger, Wilhelm M Windisch
Background: Subclinical zinc deficiency (SZD) represents the common zinc malnutrition phenotype. However, its association with oxidative stress is not well understood. The heart muscle may be a promising target for studying early changes in redox metabolism.Objective: We investigated the effects of short-term SZD on cardiac redox metabolism in weaned piglets.Methods: Forty-eight weaned German Large White × Landrace × Piétrain piglets (50% castrated males and 50% females; body weight of 8.5 kg) were fed diets with different zinc concentrations for 8 d...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28202634/dietary-patterns-are-associated-with-metabolic-outcomes-among-adult-samoans-in-a-cross-sectional-study
#6
Dongqing Wang, Nicola L Hawley, Avery A Thompson, Viali Lameko, Muagatutia Sefuiva Reupena, Stephen T McGarvey, Ana Baylin
Background: The Samoan population has been undergoing a nutrition transition toward more imported and processed foods and a more sedentary lifestyle.Objectives: We aimed to identify dietary patterns in Samoa and to evaluate their associations with metabolic outcomes.Methods: The sample of this cross-sectional study includes 2774 Samoan adults recruited in 2010 (1104 with metabolic syndrome compared with 1670 without). Principal component analysis on food items from a 104-item food-frequency questionnaire was used to identify dietary patterns...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179493/nutritional-and-lipid-modulation-of-pcsk9-effects-on-cardiometabolic-risk-factors
#7
REVIEW
Jacqueline A Krysa, Teik Chye Ooi, Spencer D Proctor, Donna F Vine
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease involved in the regulation of LDL receptor (LDLR) expression and apolipoprotein B lipoprotein cholesterol metabolism. Hepatic PCSK9 protein expression, activity, and secretion have been shown to affect cholesterol homeostasis. An upregulation of hepatic PSCK9 protein leads to increased LDLR degradation, resulting in decreased uptake of apoB lipoproteins and a consequent increase in the plasma concentration of these lipoproteins, including LDL and chylomicron remnants...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179492/indicator-amino-acid-derived-estimate-of-dietary-protein-requirement-for-male-bodybuilders-on-a-nontraining-day-is-several-fold-greater-than-the-current-recommended-dietary-allowance
#8
Arash Bandegan, Glenda Courtney-Martin, Mahroukh Rafii, Paul B Pencharz, Peter Wr Lemon
Background: Despite a number of studies indicating increased dietary protein needs in bodybuilders with the use of the nitrogen balance technique, the Institute of Medicine (2005) has concluded, based in part on methodologic concerns, that "no additional dietary protein is suggested for healthy adults undertaking resistance or endurance exercise."Objective: The aim of the study was to assess the dietary protein requirement of healthy young male bodybuilders ( with ≥3 y training experience) on a nontraining day by measuring the oxidation of ingested l-[1-(13)C]phenylalanine to (13)CO2 in response to graded intakes of protein [indicator amino acid oxidation (IAAO) technique]...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179491/increases-in-plasma-tryptophan-are-inversely-associated-with-incident-cardiovascular-disease-in-the-prevenci%C3%A3-n-con-dieta-mediterr%C3%A3-nea-predimed-study
#9
Edward Yu, Miguel Ruiz-Canela, Marta Guasch-Ferré, Yan Zheng, Estefania Toledo, Clary B Clish, Jordi Salas-Salvadó, Liming Liang, Dong D Wang, Dolores Corella, Montse Fitó, Enrique Gómez-Gracia, José Lapetra, Ramón Estruch, Emilio Ros, Montserrat Cofán, Fernando Arós, Dora Romaguera, Lluis Serra-Majem, Jose V Sorlí, Frank B Hu, Miguel A Martinez-Gonzalez
Background: During development of cardiovascular disease (CVD), interferon-γ-mediated inflammation accelerates degradation of tryptophan into downstream metabolites. A Mediterranean diet (MedDiet) consisting of a high intake of extra-virgin olive oil (EVOO), nuts, fruits, vegetables, and cereals has been demonstrated to lower the risk of CVD. The longitudinal relation between tryptophan and its downstream metabolites and CVD in the context of a MedDiet is unstudied.Objective: We sought to investigate the relation between metabolites in the tryptophan-kynurenine pathway and CVD in the context of a MedDiet pattern...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179490/paleolithic-and-mediterranean-diet-pattern-scores-are-inversely-associated-with-all-cause-and-cause-specific-mortality-in-adults
#10
Kristine A Whalen, Suzanne Judd, Marjorie L McCullough, W Dana Flanders, Terryl J Hartman, Roberd M Bostick
Background: Poor diet quality is associated with a higher risk of many chronic diseases that are among the leading causes of death in the United States. It has been hypothesized that evolutionary discordance may account for some of the higher incidence and mortality from these diseases.Objective: We investigated associations of 2 diet pattern scores, the Paleolithic and the Mediterranean, with all-cause and cause-specific mortality in the REGARDS (REasons for Geographic and Racial Differences in Stroke) study, a longitudinal cohort of black and white men and women ≥45 y of age...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179489/the-dietary-inflammatory-index-is-associated-with-colorectal-cancer-risk-in-the-multiethnic-cohort
#11
Brook E Harmon, Michael D Wirth, Carol J Boushey, Lynne R Wilkens, Emma Draluck, Nitin Shivappa, Susan E Steck, Lorne Hofseth, Christopher A Haiman, Loic Le Marchand, James R Hébert
Background: Diet is known to influence systemic inflammation, a recognized risk factor for colorectal cancer (CRC). Studies in ethnically diverse populations that examine the association between dietary inflammatory potential and CRC incidence are limited.Objectives: We used the Dietary Inflammatory Index to clarify the relation between the inflammatory potential of diet and CRC incidence across racial/ethnic groups. We hypothesized that proinflammatory diets would be associated with an increased risk of CRC, and that these associations may differ across racial/ethnic groups...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179488/social-franchising-and-a-nationwide-mass-media-campaign-increased-the-prevalence-of-adequate-complementary-feeding-in-vietnam-a-cluster-randomized-program-evaluation
#12
Rahul Rawat, Phuong Hong Nguyen, Lan Mai Tran, Nemat Hajeebhoy, Huan Van Nguyen, Jean Baker, Edward A Frongillo, Marie T Ruel, Purnima Menon
Background: Rigorous evaluations of health system-based interventions in large-scale programs to improve complementary feeding (CF) practices are limited. Alive & Thrive applied principles of social franchising within the government health system in Vietnam to improve the quality of interpersonal counseling (IPC) for infant and young child feeding combined with a national mass media (MM) campaign and community mobilization (CM). Objective: We evaluated the impact of enhanced IPC + MM + CM (intensive) compared with standard IPC + less-intensive MM and CM (nonintensive) on CF practices and anthropometric indicators...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179487/supplemental-citrulline-is-more-efficient-than-arginine-in-increasing-systemic-arginine-availability-in-mice
#13
Umang Agarwal, Inka C Didelija, Yang Yuan, Xiaoying Wang, Juan C Marini
Background: Arginine is considered to be an essential amino acid in various (patho)physiologic conditions of high demand. However, dietary arginine supplementation suffers from various drawbacks, including extensive first-pass extraction. Citrulline supplementation may be a better alternative than arginine, because its only fate in vivo is conversion into arginine.Objective: The goal of the present research was to determine the relative efficiency of arginine and citrulline supplementation to improve arginine availability...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179486/serum-25-hydroxyvitamin-d-has-a-modest-positive-association-with-leukocyte-telomere-length-in-middle-aged-us-adults
#14
Julia Beilfuss, Carlos A Camargo, Elena Kamycheva
Background: Vitamin D deficiency has been linked to all-cause mortality and cancer. However, the biological plausibility of these associations is not well established. Leukocyte telomere length (LTL) shortening is associated with aging and is a hallmark of genomic instability and carcinogenesis.Objective: We aimed to investigate the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and LTL in the general US population.Methods: We analyzed data from the US NHANES 2001-2002. The study population comprised 1542 younger adults (aged 20-39 y), 1336 middle-aged adults (aged 40-59 y), and 1382 older adults (aged ≥60 y)...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28148687/chemical-composition-but-not-specific-surface-area-affects-calcium-retention-of-nanostructured-calcium-compounds-in-growing-rats
#15
Lidija Posavec, Florentine M Hilty, Jeannine Baumgartner, Hylton Buntting, Monika Hilbe, Marlena Kruger, Frank Krumeich, Anne F Grobler, Michael B Zimmermann
BACKGROUND: Low dietary calcium intake and bioavailability may adversely affect bone health. Reducing the size of calcium compounds increases their specific surface area (SSA, expressed as m(2)/g) and may increase calcium dissolution and bioavailability. OBJECTIVE: We investigated the influence of SSA and chemical composition on the bioavailability of calcium and compared in vitro calcium dissolution with in vivo absorption. METHODS: Calcium dissolution was measured in 0...
February 1, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28148686/maize-milling-method-affects-growth-and-zinc-status-but-not-provitamin-a-carotenoid-bioefficacy-in-male-mongolian-gerbils
#16
Bryan M Gannon, Kevin V Pixley, Sherry A Tanumihardjo
BACKGROUND: Vitamin A (VA) and zinc deficiencies are prevalent. Maize is a common staple, and milling affects nutrient and nutrient-modifier profiles. OBJECTIVE: We investigated the interaction of maize milling methods (i.e., whole grain compared with refined) in male Mongolian gerbils aged 29-35 d with conventionally bred provitamin A-biofortified (orange) or white maize on VA and zinc status. METHODS: Study 1 (n = 67) was a 2 × 3 milling (whole compared with refined) by VA [no-vitamin A placebo group (VA-), orange, and VA-supplemented group (VA+)] design, with 4 wk of VA depletion followed by six 4-wk treatments (n = 10/treatment)...
February 1, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28148685/iron-bioavailability-from-ferric-pyrophosphate-in-extruded-rice-cofortified-with-zinc-sulfate-is-greater-than-when-cofortified-with-zinc-oxide-in-a-human-stable-isotope-study
#17
Laura Hackl, Michael B Zimmermann, Christophe Zeder, Megan Parker, Paul W Johns, Richard F Hurrell, Diego Moretti
BACKGROUND: Extruded rice grains are often cofortified with iron and zinc. However, it is uncertain if the addition of zinc to iron-fortified rice affects iron absorption and whether this is zinc-compound specific. OBJECTIVE: We investigated whether zinc, added as zinc oxide (ZnO) or zinc sulfate (ZnSO4), affects human iron absorption from extruded rice fortified with ferric pyrophosphate (FePP). METHODS: In 19 iron-depleted Swiss women (plasma ferritin ≤16...
February 1, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28148684/maternal-midpregnancy-plasma-trans-18-1-fatty-acid-concentrations-are-positively-associated-with-risk-of-maternal-vascular-complications-and-child-low-birth-weight
#18
Nina H Grootendorst-van Mil, Henning Tiemeier, Jolien Steenweg-de Graaff, Vincent Wv Jaddoe, Eric Ap Steegers, Régine Pm Steegers-Theunissen
BACKGROUND: Evidence is plentiful that trans fatty acids (TFAs) induce vascular inflammation with adverse metabolic consequences. However, it is not clear whether TFAs increase the risk of vascular pregnancy complications such as preeclampsia. OBJECTIVE: We investigated associations between midpregnancy maternal plasma trans 18:1 fatty acid (t18:1) concentrations and pregnancy course and outcomes. METHODS: Participants were 6695 pregnant women and newborns from the Generation R Study, Rotterdam, Netherlands (enrollment in 2001-2005)...
February 1, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28148683/the-contribution-of-intestinal-gluconeogenesis-to-glucose-homeostasis-is-low-in-2-day-old-pigs
#19
Claire Cherbuy, Pierre Vaugelade, Simon Labarthe, Edith Honvo-Houeto, Béatrice Darcy-Vrillon, Malcolm Watford, Pierre-Henri Duée
BACKGROUND: Active gluconeogenesis is essential to maintain blood glucose concentrations in neonatal piglets because of the high glucose requirements after birth. In several adult mammals, the liver, kidney, and possibly the gut may exhibit gluconeogenesis during fasting and insulinopenic conditions. During the postnatal period, the intestine expresses all of the gluconeogenic enzymes, suggesting the potential for gluconeogenesis. Galactose in milk is a potential gluconeogenic precursor for newborns...
February 1, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28148682/dietary-protein-modifies-the-effect-of-the-mc4r-genotype-on-2-year-changes-in-appetite-and-food-craving-the-pounds-lost-trial
#20
Tao Huang, Yan Zheng, Adela Hruby, Donald A Williamson, George A Bray, Yiru Shen, Frank M Sacks, Lu Qi
BACKGROUND: The melanocortin-4 receptor (MC4R) plays a pivotal role in the regulation of appetite and eating behavior. Variants in the MC4R gene have been related to appetite and obesity. OBJECTIVE: We aimed to examine whether weight-loss diets modified the effect of the "obesity-predisposing" MC4R genotype on appetite-related measures in a randomized controlled trial. METHODS: A total of 811 overweight and obese subjects [25 ≤ body mass index (BMI; kg/m(2)) ≤ 40] aged 30-70 y were included in the 2-y POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) trial...
February 1, 2017: Journal of Nutrition
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