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Journal of Nutrition

Cecilie Kyrø, Anne Tjønneland, Kim Overvad, Anja Olsen, Rikard Landberg
BACKGROUND: Type 2 diabetes is a major health concern worldwide. Whole grains and cereal fiber may offer protective effects on type 2 diabetes risk. However, few studies have been conducted in cohorts with detailed information on whole-grain cereal intakes and product types and with wide ranges of intake. Objective: We investigated the associations between whole-grain intake, including intakes of different cereal types and products, and the risk of type 2 diabetes in a population with wide and diverse whole-grain intake...
July 17, 2018: Journal of Nutrition
Samuel P Scott, Laura E Murray-Kolb, Michael J Wenger, Shobha A Udipi, Padmini S Ghugre, Erick Boy, Jere D Haas
BACKGROUND: Iron deficiency remains the most prevalent micronutrient deficiency globally, but few studies have examined how iron status relates to cognition in adolescents. Iron biofortification of staple food crops is being scaled up, yet it is unknown whether consuming biofortified crops can benefit cognition. Objective: Our objective was to determine the efficacy of iron-biofortified pearl millet in improving attention and memory in Indian school-going adolescents...
July 17, 2018: Journal of Nutrition
Linda M Richter, F Mark Orkin, Gabriela D Roman, Darren L Dahly, Bernardo L Horta, Santosh K Bhargava, Shane A Norris, Aryeh D Stein
Background: Early growth faltering accounts for one-third of child deaths, and adversely impacts the health and human capital of surviving children. Social as well as biological factors contribute to growth faltering, but their relative strength and interrelations in different contexts have not been fully described. Objective: The aim of this study was to use structural equation modelling to explore social and biological multidetermination of child height at age 2 y in longitudinal data from 4 birth cohort studies in low- and middle-income countries...
July 13, 2018: Journal of Nutrition
JoAnn Kerperien, Désirée Veening-Griffioen, Tjalling Wehkamp, Betty C A M van Esch, Gerard A Hofman, Paquita Cornelissen, Louis Boon, Prescilla V Jeurink, Johan Garssen, Leon M J Knippels, Linette E M Willemsen
Background: Dietary nondigestible, short-chain galacto-, long-chain fructo-, and pectin-derived acidic oligosaccharides (GFAs) lower the effector response in cow-milk-allergic (CMA) mice; and forkhead box P3 (Foxp3)-positive regulatory T cells (Tregs) were shown to contribute to this. Objective: The aim of this study was to assess the contribution of interleukin 10 (IL-10) and transforming growth factor β (TGF-β) to the protective effect of the GFA diet in CMA mice...
July 9, 2018: Journal of Nutrition
Alejandra M Wiedeman, Cecil M Y Chau, Ruth E Grunau, Deanna McCarthy, Karin Yurko-Mauro, Roger A Dyer, Sheila M Innis, Angela M Devlin
Background: Choline is an important nutrient during development. However, there are limited data on dietary choline intake and status in toddlers and the relation to neurodevelopmental outcomes. Objective: This study assessed dietary choline intake and status in healthy toddlers at ages 1 and 2 y and determined the relation to neurodevelopmental outcomes. Methods: This is a secondary analysis of data from healthy toddlers enrolled in a double-blind, randomized controlled trial of long-chain polyunsaturated fatty acid supplementation between ages 1 and 2 y...
July 9, 2018: Journal of Nutrition
Quan-Lan Jasmine Lew, Tazeen Hasan Jafar, Aizhen Jin, Jian-Min Yuan, Woon-Puay Koh
Background: Cross-sectional studies suggest that coffee drinking is associated with better renal function. However, to our knowledge, no prospective study has examined its relation with the risk of end-stage renal disease (ESRD). Objective: We examined the relations between coffee, tea, soda, and total caffeine consumption and the risk of ESRD among middle-aged and older Chinese in Singapore. Methods: We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women aged 45-74 y at recruitment from 1993 to 1998...
July 9, 2018: Journal of Nutrition
Nithya Neelakantan, Woon-Puay Koh, Jian-Min Yuan, Rob M van Dam
Background: Diet-quality indexes have been associated with a lower risk of chronic disease mortality in Western populations, but it is unclear whether these indexes reflect protective dietary patterns in Asian populations. Objective: We examined the association between Alternative Healthy Eating Index-2010 (AHEI-2010), alternate Mediterranean diet (aMED), Dietary Approaches to Stop Hypertension (DASH), and Healthy Diet Indicator (HDI) scores and the risk of all-cause cardiovascular disease (CVD), cancer, and respiratory disease mortality...
July 3, 2018: Journal of Nutrition
Fabrice Bonnet, Aude Tavenard, Maxime Esvan, Bruno Laviolle, Mélanie Viltard, Eve M Lepicard, Fabrice Lainé
Background: The effects of the regular intake of beverages containing high-intensity sweeteners on insulin sensitivity in healthy individuals remain controversial. Objective: This trial compared the effects of the consumption of a carbonated beverage containing aspartame and acesulfame K (high-intensity sweeteners beverage-HISB) with those of an unsweetened, no-calorie carbonated beverage (UB) on insulin sensitivity and secretion in nondiabetic adults. Methods: SEDULC was a randomized, double-blind, crossover study...
July 3, 2018: Journal of Nutrition
Ebrahim Kouchaki, Maryam Afarini, Javad Abolhassani, Naghmeh Mirhosseini, Fereshteh Bahmani, Seyed Ali Masoud, Zatollah Asemi
Background: Combined omega-3 fatty acid and vitamin D supplementation may improve multiple sclerosis (MS) by correcting metabolic abnormalities and attenuating oxidative stress and inflammation. Objective: This study aimed to determine the effects of ω-3 fatty acid and vitamin D cosupplementation on the disability score and metabolic status of patients with MS. Methods: This was a randomized, placebo-controlled clinical trial with Expanded Disability Status Scale (EDSS) score and inflammation as primary outcomes and oxidative stress biomarkers and metabolic profile as secondary outcomes...
July 3, 2018: Journal of Nutrition
Szimonetta Lohner, Viktória Jakobik, Krisztina Mihályi, Sara Soldi, Sotirios Vasileiadis, Stephan Theis, Manuela Sailer, Carolin Sieland, Károly Berényi, Günther Boehm, Tamás Decsi
Background: Inulin-type fructans used in formula have been shown to promote microbiota composition and stool consistency closer to those of breastfed infants and to have beneficial effects on fever occurrence, diarrhea, and incidence of infections requiring antibiotic treatment in infants. Objectives: The primary study aim was to explore whether prophylactic supplementation with prebiotic fructans is able to influence the frequency of infectious diseases in kindergarten children during a winter period...
July 3, 2018: Journal of Nutrition
Qianwen Ding, Zhen Zhang, Chao Ran, Suxu He, Yalin Yang, Zhenyu Du, Jinxiong Zhang, Zhigang Zhou
Background: Palmitic acid (PA) is the main saturated fatty acid naturally occurring in animal fats and vegetable oils. In recent decades, palm oil, an alternative lipid source containing high amounts of PA, has been widely used to replace fish oil in aquafeed. Objective: We investigated the hepatotoxicity of PA in zebrafish and the underlying mechanism. Methods: One-month-old zebrafish fed a high-fat diet (HFD) containing 16% soybean oil and 3 PA-incorporated HFDs [4%, 8%, and 12% PA (12PA)] for 2 wk (experiment 1) and 4 wk (experiment 2) were used to evaluate PA-induced liver damage and endoplasmic reticulum (ER) stress...
June 30, 2018: Journal of Nutrition
Stephen R Hennigar, Harris R Lieberman, Victor L Fulgoni, James P McClung
Background: Serum zinc concentration is used to assess the zinc status of populations. Cutoffs for serum zinc were developed on the basis of data from the second NHANES (1976-1980). Objective: The objective of this study was to evaluate serum zinc concentrations in the US population and to determine factors affecting serum zinc with the use of NHANES 2011-2014. Methods: Serum zinc was determined in males and females aged ≥6 y with the use of NHANES 2011-2014 (n = 4347)...
June 27, 2018: Journal of Nutrition
Antonio Perfecto, Ildefonso Rodriguez-Ramiro, Jorge Rodriguez-Celma, Paul Sharp, Janneke Balk, Susan Fairweather-Tait
Background: Iron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an endocytic mechanism, independent of divalent metal ion transporter 1 (DMT-1), the transporter for nonheme iron. Objective: Our overall aim was to examine the potential of purified ferritin from peas (Pisum sativum) as a food supplement by measuring its stability under gastric pH treatment and the mechanisms of iron uptake into Caco-2 cells...
June 22, 2018: Journal of Nutrition
Farnush Bakhshimoghaddam, Kamran Shateri, Morad Sina, Maryam Hashemian, Mohammad Alizadeh
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed and developing countries. The use of synbiotics has been proposed as a probable management strategy for patients with NAFLD. Objective: We investigated the effects of synbiotic yogurt on hepatic steatosis and liver enzymes as primary outcomes and on oxidative stress markers, adipokine concentration, and gut peptide concentration as secondary outcomes in patients with NAFLD...
June 20, 2018: Journal of Nutrition
Yixuan Li, Jingxuan Wang, Fazheng Ren, Wei Zhang, Hao Zhang, Liang Zhao, Ming Zhang, Wei Cui, Xiaobin Wang, Huiyuan Guo
Background: Lactoferrin (LF), as a major functional protein in dairy products, is known to modulate bone anabolic effects. However, the underlying molecular mechanisms remain unclear; the receptor of LF in osteoblast differentiation has not been identified. Objective: The aims of the study were to 1) illuminate whether the receptor of LF in osteoblast differentiation is transforming growth factor-β (TGF-β) receptor (TβR) II and 2) determine whether the TGF-β signaling pathway is activated by LF in promoting osteogenesis in vitro and in vivo, in addition to P38 and extracellular signal-regulated kinase (ERK) pathways...
June 20, 2018: Journal of Nutrition
Phuong Hong Nguyen, Edward A Frongillo, Tina Sanghvi, Gargi Wable, Zeba Mahmud, Lan Mai Tran, Bachera Aktar, Kaosar Afsana, Silvia Alayon, Marie T Ruel, Purnima Menon
Background: Although husbands may provide support during pregnancy, limited evidence exists on how to promote husbands' engagement and what impact it has. Alive & Thrive integrated nutrition-focused interventions, targeting both wives and husbands, through an existing Maternal, Neonatal, and Child Health (MNCH) platform in Bangladesh. Objectives: We evaluated 1) the impact of a nutrition-focused MNCH program, compared with the standard MNCH program, on husbands' behavioral determinants (i...
June 20, 2018: Journal of Nutrition
Samuel M Kim, Di Zhao, Anna J Podolanczuk, Pamela L Lutsey, Eliseo Guallar, Steven M Kawut, R Graham Barr, Ian H de Boer, Bryan R Kestenbaum, David J Lederer, Erin D Michos
Background: Activated vitamin D has anti-inflammatory properties. 25-Hydroxyvitamin D [25(OH)D] deficiency might contribute to subclinical interstitial lung disease (ILD). Objective: We examined associations between serum 25(OH)D concentrations and subclinical ILD among middle-aged to older adults who were free of cardiovascular disease at baseline. Methods: We studied 6302 Multi-Ethnic Study of Atherosclerosis (MESA) participants who had baseline serum 25(OH)D concentrations and computed tomography (CT) imaging spanning ≤ 10 y...
June 19, 2018: Journal of Nutrition
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No abstract text is available yet for this article.
June 19, 2018: Journal of Nutrition
Lindsay N Kohler, Ana Florea, Connor P Kelley, Sherry Chow, Paul Hsu, Ken Batai, Kathylynn Saboda, Peter Lance, Elizabeth T Jacobs
Background: Selenium, an essential trace element, has been investigated as a potential cancer prevention agent. However, several studies have indicated that selenium supplementation may be associated with an increased risk of type 2 diabetes (T2D), although an equivocal relation of this nature requires confirmation. Objective: We examined the association between baseline plasma concentrations of selenium and the prevalence of T2D, as well as whether participant characteristics or intake of other antioxidant nutrients modified this relation...
June 19, 2018: Journal of Nutrition
Teresa A Marshall, Alexandra M Curtis, Joseph E Cavanaugh, John J Warren, Steven M Levy
Background: Height is an indicator of nutritional status; linear growth faltering has recognized consequences for cognitive, emotional, and chronic disease risk. Although height is routinely studied in developing countries, less attention is given to height in the United States. Objective: The objective of this study was to identify longitudinal associations between childhood and adolescent beverage intakes, nutrient adequacy, or energy intake and height in a birth cohort...
June 19, 2018: Journal of Nutrition
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