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Arquivos Brasileiros de Endocrinologia e Metabologia

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https://www.readbyqxmd.com/read/25627061/ptpn2-gene-polymorphisms-are-associated-with-type-1-diabetes-mellitus-in-brazilian-subjects
#1
LETTER
Jakeline Rheinheimer, Luis Henrique Canani, Daisy Crispim
No abstract text is available yet for this article.
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627060/ptpn2-a-potential-therapeutic-target-for-type-1-diabetes
#2
LETTER
Shan-Shan Liu, Lou Ji-Quan, Ding Ye
No abstract text is available yet for this article.
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627059/response-to-the-letter-red-cell-distribution-width-in-subclinical-hypothyroidism
#3
LETTER
Hea Min Yu, Kang Seo Park, Jae Min Lee
No abstract text is available yet for this article.
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627058/red-cell-distribution-width-in-subclinical-hypothyroidism
#4
LETTER
Sevket Balta, Mustafa Aparci, Cengiz Ozturk, Sait Demirkol, Turgay Celik, Atila Iyisoy
No abstract text is available yet for this article.
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627057/response-to-the-letter-angiotensin-ii-induced-insulin-resistance
#5
LETTER
Marcos M Lima-Martínez, Gabriel López-Mendez, Rodolfo Odreman, José H Donis, Mariela Paoli
No abstract text is available yet for this article.
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627056/angiotensin-ii-induced-insulin-resistance
#6
LETTER
Eda Demir Onal, Serhat Isik, Dilek Berker, Serdar Guler
No abstract text is available yet for this article.
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627055/-giant-metastasis-of-thyroid-papillar-carcinoma
#7
Marcelo Benedito Menezes, Antonio Augusto Tupinambá Bertelli, Mauro Ajaj Saieg, Tales Maciel de Camargo, Antonio José Gonçalves
No abstract text is available yet for this article.
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627054/a-case-of-thyroid-hormone-resistance-a-rare-mutation
#8
Ana Pires Gonçalves, José Maria Aragüés, Ema Nobre, Ana Paula Barbosa, Mario Mascarenhas
Reduced sensitivity to thyroid hormones (RSTH) is a rare disease that affects about 3,000 individuals, belonging to about 1,000 families. It results from reduced intracellular action of thyroid hormones (TH) genetically determined and manifests as persistent hyperthyroxinemia with non-suppressed thyroid-stimulating hormone (TSH). We describe a 67-years old, Caucasian woman, with past history of subtotal thyroidectomy due to diffuse goiter, who presents with a recurrence of goiter. Although she is clinically euthyroid, laboratory evaluation shows persistent hyperthyroxinemia with non-suppressed TSH...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627053/large-thyroid-cyst-in-a-patient-with-congenital-hypothyroidism
#9
Mahmoud Ali Kaykhaei, Zahra Heidari, Ahmad Mehrazin
Thyroid hormone biosynthetic defects are rare causes of congenital hypothyroidism. Although, initial presentations are usually diffuse goiter and hypothyroidism, subsequently they may develop thyroid nodules and or thyroid cancer. We describe a case of hypothyroidism due to dyshormonogenesis whose one of the previously solid nodules degenerates into a large cyst. A 22-year-old male was referred to our clinic for evaluation of enlarging thyroid nodule. Hypothyroidism was diagnosed in infancy, however due to poor compliance to treatment TSH values were elevated most of the times...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627052/marrow-hypoplasia-a-rare-complication-of-untreated-grave-s-disease
#10
Juliana Garcia, Larissa de França, Vivian Ellinger, Mônica Wolff
Atypical presentation forms of hyperthyroidism are always a challenge to the clinician. We present a female patient with the typical symptoms of thyrotoxicosis, without any thionamides treatment before, associated with pancytopenia, which recovered after euthyroidism state was achieved. Although the major cases of pancytopenia in Grave's disease are seen as a complication of antithyroid drugs (thioamides), in this case report the alteration in blood tests was associated with untreated hyperthyroidism. In the literature review, we found 19 case reports between 1981 to 2012, but it has been related to a hypercellular bone marrow with periferic destruction...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627051/-reduction-of-functional-mobility-and-cognitive-capacity-in-type-2-diabetes-mellitus
#11
Mari Cassol Ferreira, Joana Tozatti, Silvia Maria Fachin, Patricia Pereira de Oliveira, Rosa Ferreira dos Santos, Maria Elisabeth Rossi da Silva
OBJECTIVES: The aim of the present study was to evaluate the functional mobility and its relationship to cognitive ability in patients with type 2 diabetes (T2DM), age between 50 and 65 years and under 10 years of diagnosis. MATERIALS AND METHODS: An observational, analytical and cross-sectional study, involving no diabetic and type 2 diabetic individuals with inadequate glycemic control, selected by convenience sampling. In both groups, were administered structured questionnaire and cognitive assessment with Mini-Mental State Examination (MMSE) and the clock drawing test (CDT), besides assessment of functional mobility by the Timed Up & Go (TUG)...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627050/evaluation-of-cytopathological-findings-in-thyroid-nodules-with-macrocalcification-macrocalcification-is-not-innocent-as-it-seems
#12
Dilek Arpaci, Didem Ozdemir, Neslihan Cuhaci, Ahmet Dirikoc, Aylin Kilicyazgan, Gulnur Guler, Reyhan Ersoy, Bekir Cakir
OBJECTIVE: Microcalcification is strongly correlated with papillary thyroid cancer. It is not clear whether macrocalcification is associated with malignancy. In this study, we aimed to assess the result of fine needle aspiration biopsies (FNAB) of thyroid nodules with macrocalcifications. SUBJECTS AND METHODS: We retrospectively evaluated 269 patients (907 nodules). Macrocalcifications were classified as eggshell and parenchymal macrocalcification. FNAB results were divided into four groups: benign, malignant, suspicious for malignancy, and non-diagnostic...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627049/thyroid-nodules-and-thyroid-cancer-in-graves-disease
#13
Abbas Ali Tam, Cafer Kaya, Fevzi Balkan Mehmet Kılıç, Reyhan Ersoy, Bekir Çakır
OBJECTIVE: The frequency of thyroid nodules accompanying Graves' disease and the risk of thyroid cancer in presence of accompanying nodules are controversial. The aim of this study was to evaluate the frequency of thyroid nodules and the risk of thyroid cancer in patients operated because of graves' disease. SUBJECTS AND METHODS: Five hundred and twenty-six patients in whom thyroidectomy was performed because of Graves' disease between 2006 and 2013 were evaluated retrospectively...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627048/the-prevalence-of-the-metabolic-syndrome-increases-through-the-quartiles-of-thyroid-stimulating-hormone-in-a-population-based-sample-of-euthyroid-subjects
#14
Alexander Shinkov, Anna-Maria Borissova, Roussanka Kovatcheva, Iliana Atanassova, Jordan Vlahov, Lilia Dakovska
OBJECTIVE: The aim of the study was to assess the prevalence and characteristics of metabolic syndrome (MetS) and its elements in relation to TSH in euthyroid subjects. MATERIALS AND METHODS: In the cross-sectional study, 2,153 euthyroid adults, 47.2 ± 14.5 years (20-94) with no current antithyroid or thyroid replacement therapy were enrolled. All participants filled a questionnaire on past and current morbidities, medication and smoking. Body weight, height, waist circumference, serum TSH, glucose and lipids were measured...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627047/the-tcf7l2-rs7903146-c-t-polymorphism-is-associated-with-risk-to-type-2-diabetes-mellitus-in-southern-brazil
#15
MULTICENTER STUDY
Taís S Assmann, Guilherme C K Duarte, Jakeline Rheinheimer, Lavínia A Cruz, Luís H Canani, Daisy Crispim
OBJECTIVE: The aim of this study was to investigate the association between the rs7903146 (C/T) polymorphism in the TCF7L2 gene and type 2 diabetes mellitus, in a Southern-Brazilian population. MATERIALS AND METHODS: The TCF7L2 rs7903146 polymorphism was genotyped in 953 type 2 diabetic patients and 535 non-diabetic subjects. All subjects were white. The polymorphism was genotyped by Real-Time PCR using TaqMan MGB probes (Life Technologies). Odds ratios (OR) and 95% confidence intervals (CI) were calculated for additive, recessive and dominant inheritance models...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627046/evaluation-of-percutaneous-ethanol-injections-in-benign-thyroid-nodules
#16
Camila Luhm Silva Perez, Tayane Muniz Fighera, Fabiola Miasaki, Cleo Otaviano Mesa Junior, Gilberto Jorge da Paz Filho, Hans Graf, Gisah Amaral de Carvalho
OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules. SUBJECTS AND METHODS: We evaluated 120 patients with benign thyroid nodules. Patients underwent evaluation of serum TSH and free T4, cervical ultrasound, and thyroid scintigraphy (in those with suppressed TSH levels). The application of sterile ethanol 99% was guided by ultrasound, with the injected volume amounting to one-third of the nodule volume...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627045/an-international-survey-of-screening-and-management-of-hypothyroidism-during-pregnancy-in-latin-america
#17
Mateus Fernandes da Silva Medeiros, Taise Lima de Oliveira Cerqueira, Joaquim Custódio Silva Junior, Magali Teresopolis Reis Amaral, Bijay Vaidya, Kris Gustave Poppe, Gisah Amaral de Carvalho, Silvia Gutierrez, Graciela Alcaraz, Marcos Abalovich, Helton Estrela Ramos
OBJECTIVE: To determine how endocrinologists in Latin America deal with clinical case scenarios related to hypothyroidism and pregnancy. MATERIALS AND METHODS: In January 2013, we sent an electronic questionnaire on current practice relating to management of hypothyroidism in pregnancy to 856 members of the Latin American Thyroid Society (LATS) who manage pregnant patients with thyroid disease. Subsequently, we have analyzed responses from physician members. RESULTS: Two hundred and ninety-three responders represent clinicians from 13 countries...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627044/-study-of-polymorphism-g54d-of-mbl2-gene-in-gestational-diabetes-mellitus
#18
Rejane Baggenstoss, Silvia Vanderléia Petzhold, Izabela K Michels Willemann, Francisco Simões Pabis, Paulo Gimenes, Barbara Vicente de Souza, Paulo Henrique Condeixa de França, Jean Carl Silva
OBJECTIVE: To assess the association of the G54D (rs1800450) polymorphism of the gene MBL2 in the gestational diabetes mellitus with the need for additional treatment and the occurrence of large newborns for the gestational age. SUBJECTS AND METHODS: One hundred and five patients recruited in Joinville--Brazil were evaluated between November 2010 and October 2012. Pregnant women were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627043/brown-adipose-tissue-what-have-we-learned-since-its-recent-identification-in-human-adults
#19
REVIEW
Bruno Halpern, Marcio Correa Mancini, Alfredo Halpern
Brown adipose tissue, an essential organ for thermoregulation in small and hibernating mammals due to its mitochondrial uncoupling capacity, was until recently considered to be present in humans only in newborns. The identification of brown adipose tissue in adult humans since the development and use of positron emission tomography marked with 18-fluorodeoxyglucose (PET-FDG) has raised a series of doubts and questions about its real importance in our metabolism. In this review, we will discuss what we have learnt since its identification in humans as well as both new and old concepts, some of which have been marginalized for decades, such as diet-induced thermogenesis...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25627042/bariatric-surgery-an-update-for-the-endocrinologist
#20
REVIEW
Marcio C Mancini
Obesity is a major public health problem, is associated with increased rates of mortality risk and of developing several comorbidities, and lessens life expectancy. Bariatric surgery is the most effective treatment for morbidly obese patients, reducing risk of developing new comorbidities, health care utilization and mortality. The establishment of centers of excellence with interdisciplinary staff in bariatric surgery has been reducing operative mortality in the course of time, improving surgical safety and quality...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
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