Weibo Hou, Lijun Chen, Jingzhang Ji, Songling Xiao, Hongye Linghu, Lixin Zhang, Yue Ping, Chunsheng Wang, Qingran Kong, Wenpin Cai, Xu Yang
BACKGROUND: Zygotic genome activation (ZGA) is an important event in the early embryo development, and human embryo developmental arrest has been highly correlated with ZGA failure in clinical studies. Although a few studies have linked maternal factors to mammalian ZGA, more studies are needed to fully elucidate the maternal factors that are involved in ZGA. METHODS AND RESULTS: In this study, we utilized published single-cell RNA sequencing data from a Dux-mediated mouse embryonic stem cell to induce a 2-cell-like transition state and selected potential drivers for the transition according to an RNA velocity analysis...
April 20, 2024: Molecular Biology Reports