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Journal of Nutritional Science and Vitaminology

Kazuki Ide, Hiroshi Yamada, Yohei Kawasaki, Mie Yamanaka, Nobuko Kawakami, Yusuke Katsuyama, Hidefumi Yoshida, Kang Kim, Emi Shiosaki, Akihiro Sonoda, Keizo Umegaki, Kiyoshi Harada
We previously reported lower lymphocyte vitamin C levels in individuals with type 2 diabetes mellitus and in individuals with severe Parkinson's disease. Oxidative stress has been proposed to play a key role in the progression of Alzheimer's disease. Thus, the objective of this study was to investigate the association between peripheral levels of vitamin C and the progression of cognitive dysfunction in Alzheimer's disease. Fifty individuals with Alzheimer's disease being treated at Shizuoka General Hospital were consecutively enrolled in this study from December 2009 to March 2015 (76...
2016: Journal of Nutritional Science and Vitaminology
Teruyoshi Tanaka, Tatsuya Moriyama, Yukio Kawamura, Dai Yamanouchi
Aneurysm is characterized by balloon-like expansion of the arterial wall and eventual rupture of the aorta. The pathogenesis of aneurysm is associated with the degradation of matrix proteins by matrix metalloproteinases (MMPs) produced by activated macrophages. Although aneurysm is associated with significant mortality and morbidity, surgical intervention is the only proven treatment strategy. Therefore, development of therapeutic agents for aneurysm is greatly anticipated. Here, we demonstrated the protective effects of the major isoflavone puerarin, which is found in kudzu roots and vines...
2016: Journal of Nutritional Science and Vitaminology
Kazuhiro Kubo, Ayano Koido, Misako Kitano, Hirotaka Yamamoto, Morio Saito
As bioactive ingredients of functional foods, dietary fiber and wheat albumin (WA) are known to suppress hyperglycemia in patients with type 2 diabetes mellitus. The combined effects of these bioactive ingredients were examined using an animal model of type 2 diabetes mellitus. First, oral starch tolerance tests (OSTTs) with the simultaneous intake of a dietary fiber mixture (DF) and WA were performed as an acute study. Male Goto-Kakizaki rats received a soluble starch solution [700 mg/kg body weight (bw)] containing DF and/or WA (each 300 mg/kg bw)...
2016: Journal of Nutritional Science and Vitaminology
Yoshihiko Minegishi, Noriyasu Ota, Satoko Soga, Akira Shimotoyodome
This study aimed to demonstrate the beneficial effects of nutritional supplementation with dietary milk fat globule membrane (MFGM) on physical performance and skeletal muscle function in healthy adults aged 60 and over with semiweekly light exercise. The study was designed as a randomized double-blind controlled trial. Twenty-two Japanese participants (10 men, 12 women) aged 60-73 y were assigned to one of two groups (11 [5 men, 6 women] in each). One group received MFGM tablets (1 g MFGM/d), and the other received placebo tablets daily for 10 wk...
2016: Journal of Nutritional Science and Vitaminology
Nami Yamanaka, Shinichiro Saito, Noriko Osaki, Sakura Kamei, Haruo Nakamura, Yoshihisa Katsuragi
This study investigated the effect of a single oral ingestion of alpha-linolenic acid-enriched diacylglycerol (ALA-DAG) on postprandial serum triglyceride (TG) levels. A randomized, double-blind, controlled, crossover study was performed in subjects with normal or moderately high fasting serum TG levels. Subjects ingested 0.00 g [control: triacylglycerol; TAG (rapeseed oil)], 1.25 g (1.25-g: mixture of 1.25 g ALA-DAG and 1.25 g TAG), or 2.50 g (2.50 g) of ALA-DAG in random order with a 6-d washout period. Serum TG levels were evaluated in the fasting state, and at 2, 3, 4, and 6 h after the test meal...
2016: Journal of Nutritional Science and Vitaminology
Shuxiang Li, Xin Gao, Yancai Wei, Gengchao Zhu, Chen Yang
Previous studies have identified an association between iron deficiency and thyroid function. We aimed to determine if there is a relationship between iron deficiency and thyroid function during the first trimester of pregnancy. Two thousand five hundred eighty-one pregnant women who presented for the first prenatal care were enrolled and divided into three groups, the mild iron deficiency (MID) group, iron deficiency anemia (IDA) group and normal control (NC) group, according to serum ferritin and hemoglobin levels...
2016: Journal of Nutritional Science and Vitaminology
Kalpana Poudel-Tandukar
B vitamins have beneficial roles in mental health functional impairments; however, research on the role of B vitamins in depression among HIV-infected persons is limited. This study assessed the association between dietary B vitamin intake and depressive symptoms in a cohort of HIV-infected persons. A cross-sectional survey was conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 y residing in the Kathmandu, Nepal. The Beck Depression Inventory-I was used to measure depression, with a cutoff score of 20 or higher...
2016: Journal of Nutritional Science and Vitaminology
Akiko Mizote, Mika Yamada, Chiyo Yoshizane, Norie Arai, Kazuhiko Maruta, Shigeyuki Arai, Shin Endo, Rieko Ogawa, Hitoshi Mitsuzumi, Toshio Ariyasu, Shigeharu Fukuda
We previously performed animal studies that suggested that trehalose potentially prevents the development of metabolic syndrome in humans. To evaluate this possibility, we examined whether trehalose suppressed the progression of insulin resistance in a placebo-controlled, double-blind trial in 34 subjects with a body mass index (BMI) ≥23. The subjects were divided into two groups and were assigned to ingest either 10 g/d of trehalose or sucrose with meals for 12 wk. During the study, body composition and blood biochemical parameters were measured at week 0, 8, and 12...
2016: Journal of Nutritional Science and Vitaminology
Ai Tsuji, Rina Noguchi, Toshinobu Nakamura, Katsumi Shibata
Spindle defect and chromosome misalignment occuring in oocyte meiosis induce nondisjunction. Nondisjunction causes Down syndrome, also known as trisomy 21. Folic acid (FA) is an essential nutrient composition for fetal growth and development. It has been reported that FA nutritional status is associated with the risk of Down syndrome. However, to our knowledge, little is known about the effect of FA deficiency on abnormal oocytes (spindle defects, chromosome misalignments and immature oocyte) in vivo. In the present study, we investigate the effects of FA deficiency on oocyte meiosis in female mice...
2016: Journal of Nutritional Science and Vitaminology
Shozo Sugiura
No abstract text is available yet for this article.
2016: Journal of Nutritional Science and Vitaminology
Fei Teng, Tomohiro Bito, Shigeo Takenaka, Yukinori Yabuta, Fumio Watanabe
In this study, we determined the vitamin B12 content of commercially available century eggs (pidan) and characterized their vitamin B12 compositions in detail. The egg yolk and white of century eggs (each 100 g wet weight) contained 1.9±0.6 and 0.8±0.3 μg of vitamin B12, respectively. The vitamin B12 compounds purified from the egg yolk and white were identified as vitamin B12 using liquid chromatography-electrospray ionization/tandem mass spectrometry. The vitamin B12 present in the yolk or white of century eggs was recovered completely in macromolecular fractions, but not in free vitamin B12 fractions by Sephadex G-50 gel filtration...
2016: Journal of Nutritional Science and Vitaminology
Yoshimi Kishimoto, Chie Taguchi, Norie Suzuki-Sugihara, Emi Saita, Mika Usuda, Wei Wang, Yasunobu Masuda, Kazuo Kondo
The egg is a nutrient-dense food and contains a number of antioxidants. The consumption of eggs has been considered to improve the balance of diets, although its impact on serum cholesterol levels has been a matter of concern in many countries. Here, we conducted a pilot study to investigate whether daily additional consumption of an egg might affect serum lipid profiles and also antioxidant status in healthy subjects. Fourteen male subjects were provided with breakfasts including a boiled egg for 4 wk. At the end of intervention, serum concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were unchanged, despite the significant increase in the intake of dietary cholesterol...
2016: Journal of Nutritional Science and Vitaminology
Yuri Kusano, Nobuko Tsujihara, Hironori Masui, Hana Kozai, Wakako Takeuchi
We investigated the effects of dietary Japanese yam (Dioscorea japonica Thunb.) on lipid metabolism. Male Wistar rats (6 wk old) were fed a high-cholesterol diet for 6 wk and then supplemented with 26% of Japanese yam or 0.5% of its constituent diosgenin for a further 4 wk of high-cholesterol feeding (C6-J4 and C6-D4 groups, respectively). In the C6-J4 group, body weight gains significantly decreased, but skeletal muscle fiber sizes in quadriceps significantly increased compared with the other groups. Furthermore, Japanese yam supplementation resulted in the reduction of triglyceride contents in their liver, quadriceps, and intra-abdominal visceral fat...
2016: Journal of Nutritional Science and Vitaminology
Teruyoshi Tanaka, Yukihiro Yokota, Hanjun Tang, Nobuhiro Zaima, Tatsuya Moriyama, Yukio Kawamura
Postmenopausal diabetes is exacerbated by estrogen deficiency. Ovariectomized (OVX) animal models can be used to develop strategies for preventing or treating postmenopausal symptoms. We previously found that a diet containing kudzu (Pueraria lobata) vine ethanol extract (PVEE) suppressed weight gain in OVX mice. Therefore, this study further elucidated how PVEE affected OVX mice. Ten-week-old OVX or sham-operated mice were fed diets containing either no PVEE (control) or 20 mg•kg(-1)•d(-1) PVEE for 8 wk, 5 mg•kg(-1)•d(-1) PVEE for 24 wk, or 20 mg•kg(-1)•d(-1) puerarin (daidzein-8-C-glucoside), a major isoflavone present in PVEE, for 10 wk...
2016: Journal of Nutritional Science and Vitaminology
Ikuo Ikeda, Kyouhei Tamakuni, Tomomi Sakuma, Ran Ozawa, Nao Inoue, Yuka Kishimoto
Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD...
2016: Journal of Nutritional Science and Vitaminology
Mariko Nakamichi, Hidetaka Wakabayashi
The purpose was to investigate the association between proton pump inhibitor (PPI) therapy and nutritional status in elderly hospitalized patients. Participants were 190 elderly patients admitted to the long-term care wards, convalescence rehabilitation wards, and community integrated care wards in January 2015. Nutritional status was assessed using the mini nutritional assessment short-form (MNA-SF). The PPI use group was compared with the PPI non-use group regarding nutrition status. Logistic regression analysis was used to examine whether the period of PPI therapy was associated independently with malnutrition following adjustment for covariates including gender, age, and serum albumin level...
2016: Journal of Nutritional Science and Vitaminology
Kae Inagaki, Yuuki Nishimura, Emiko Iwata, Sachinobu Manabe, Masahiro Goto, Yoshio Ogura, Hisako Hotta
By autoclaving, we obtained a polyphenol and dietary fiber from pea (Pisum sativum L.) pods in parallel without acid or alkali treatment or organic solvent extraction. Rats fed a high-sucrose (HS) diet containing 3% autoclaved extract (AE) for 4 wk exhibited significantly lower serum triglyceride and total cholesterol levels than rats fed a HS diet. AE and soluble dietary fiber (SDF) from AE exhibited pancreatic lipase inhibitory activity at 13.3 mg/mL in vitro. AE and insoluble dietary fiber (IDF) from AE adsorbed cholesterol...
2016: Journal of Nutritional Science and Vitaminology
Anton Janse VAN Rensburg, Friede Wenhold
Carotenoids in fruit and vegetables are important for health, yet determining dietary intake is challenging. This study aimed to establish the validity and reliability of a portable field Resonance Raman Spectroscope (RRS) in reflecting human carotenoid status. A diagnostic accuracy study involving 81 healthy adults was conducted. The RRS was the index test. Serum carotenoids (β-carotene, lycopene, lutein, and zeaxanthin) and consumption of fruit and vegetables were primary and secondary reference standards respectively...
2016: Journal of Nutritional Science and Vitaminology
Pei-Ying Lin, Fang-Yu Lin, Ting-Chun Chen, Wen-Lee Chen, Jia-Yau Doong, Saiko Shikanai, Nobuko Sarukura, Shigeru Yamamoto
In recent years, the prevalence and problem of overweight and obesity in Taiwanese children have increased. There are many reports that the excessive intake of sugar increases the risk of lifestyle-related disease. However, sugar intake in Taiwanese children is not known. In this study, we investigated sugar intake from sugar-sweetened beverages, snacks and desserts among school-age children in Kaohsiung, Taiwan. We also tried to determine the relationship between sugar intake and body mass index (BMI). We contacted all the public elementary schools (10 schools) in a district, Kaohsiung, and obtained permission from 3 schools...
2016: Journal of Nutritional Science and Vitaminology
Toshiyuki Kohri, Naoko Kaba, Tatsuki Itoh, Satoshi Sasaki
The Japanese school lunch program with milk was designed to supply 33-50% of the necessary nutrients per day and 50% of the recommended dietary allowance for calcium, which is difficult to obtain from Japanese meals. Although this program contributes to the mental and physical development of children, the effect of these meals on the bone growth in children remains unknown. Therefore, we compared the effect of school lunch with milk on bone growth between elementary school children attending schools that did not enforce the school lunch with milk program (box-lunch group) and those attending schools that did enforce the program (school-lunch group)...
2016: Journal of Nutritional Science and Vitaminology
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