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Research in Veterinary Science

Yusuke Izumi, Satoshi Takagi
Combretastatin A-4 phosphate (CA4P) induces tumor necrosis by selectively inhibiting tumor blood flow. However, the detailed mechanisms by which CA4P selectively disrupts tumor blood vessels are not well understood. Our previous study indicated that the selective blocking effect of CA4P might be related to a vascular endothelial cadherin (VE-cadherin) dysfunction in the tumor vasculature. In this study, we evaluated the vascular disrupting effect of CA4P on canine osteosarcomas xenografted into mice, focusing on VE-cadherin...
October 30, 2018: Research in Veterinary Science
Shidong Zhang, Feng Yang, Chike F Oguejiofor, Dongsheng Wang, Shuwei Dong, Zuoting Yan
This study investigated the correlation between endometrial local expressions of serum amyloid A (SAA) and haptoglobin (Hp) and severity of endometritis in 20 Chinese Holstein dairy cows at 40-60 days postpertum, aged 3-6, and 2-5 parities. Endometrial biopsies were collected and categorized into normal, mild endometritis, and severe endometritis based on clinical signs and histopathology. The protein and mRNA expression of SAA and Hp in endometrial tissue were measured using western blot and real-time PCR, respectively...
October 30, 2018: Research in Veterinary Science
E Semik-Gurgul, T Ząbek, A Fornal, M Wnuk, K Pawlina-Tyszko, A Gurgul, J Klukowska-Rötzler, C Koch, K Mählmann, M Bugno-Poniewierska
No abstract text is available yet for this article.
October 30, 2018: Research in Veterinary Science
Agnieszka Jasiecka-Mikołajczyk, Jerzy J Jaroszewski, Tomasz Maślanka
Oclacitinib (OCL) is a novel immunosuppressive agent approved for dogs that controls itch and inflammation in allergic disease via the inhibition of the JAK/STAT pathway. This paper investigates the in vitro effect of OCL, a novel Janus kinase inhibitor, on selected canine regulatory (Treg) and effector (Teff) CD4+ and CD8+ T cells. Exposure of peripheral blood lymphocytes to OCL did not affect the transcription factor Foxp3 (Forkhead Box P3 protein) expression in CD25+ CD4+ and CD25+ CD8+ T cells. Moreover, OCL did not influence constitutive CD25 expression on these cells although it reduced the activation-induced CD25 expression on CD4+ T cells...
October 29, 2018: Research in Veterinary Science
Tarmo Niine, Kristel Peetsalu, Lea Tummeleht, Ants Kuks, Toomas Orro
In neonatal period, lamb's immune system goes through rapid adaptation to the extra-uterine environment. Success of this process can influence the animal's future performance and, thus, the quantitative assessment of it would greatly benefit sheep producers. The current study was conducted to investigate the acute phase response (APR) (measured through serum amyloid A (SAA), haptoglobin (Hp) and albumin (ALB)) in relation to later life growth (measured at 122 days of age), and naturally occurring Cryptosporidium and Giardia infections in neonatal lambs grown in organic farm...
October 29, 2018: Research in Veterinary Science
Pallavi Bhardwaj, Pritam K Sidhu, M K Lonare, Rajdeep Kaur, V K Dumka, S Rampal
The single dose pharmacokinetics (PK) of marbofloxacin was compared with repeated intravenous (IV) administrations in six healthy goats at the dose rate of 2 mg/kg body weight at 24 h interval for 5 days. Blood samples were collected at times: 5, 15, 30 min and 1, 2, 4, 6, 9, 12, 24, 36, 48 and 72 h post drug administration. Plasma drug concentrations were determined by High Performance Liquid Chromatography and concentration-time data were subjected to non-compartment analysis. The MIC and MBC of marbofloxacin against Escherichia (E...
October 22, 2018: Research in Veterinary Science
Enrica Sozzi, Ana Moreno, Davide Lelli, Simona Perulli, Alice Prosperi, Emiliana Brocchi, Lorenzo Capucci, Alice Papetti, Enrico Giacomini, Giovanni Loris Alborali, Antonio Lavazza
Porcine epidemic diarrhoea virus (PEDV), belongs to the genus Alphacoronavirus in the family Coronaviridae and causes severe diarrhoea, vomiting, dehydration and high mortality in seronegative newborn piglets. Thus, a precise and rapid diagnosis of PEDV infection is important for the application of control measures to limit viral dissemination. In this investigation, a monoclonal antibodies (MAbs)-based competitive enzyme-linked immunosorbent assay (ELISA) for detecting antibodies against PEDV was developed and validated...
October 22, 2018: Research in Veterinary Science
B Y Wu, M Zhu, T Ruan, L J Li, Y N Lyu, H S Wang
Methionine (Met) is often called the first limiting amino acid in birds. Broilers have high requirement for Met, so they are at high risk of Met deficiency. The aims of the present research is to study the effects of Met deficiency on the histomorphological changes, antioxidant functions, apoptosis and cell cycle in the cecum tonsil of broilers. A batch of 120 one-day-old Cobb broilers in total are divided into two groups and fed on a Met deficiency diet or a control diet for six weeks, followed by analysis using the methods of experimental pathology, biochemical method, immunohistochemical method, ELISA, FCM, Tunel assay, and qRT-PCR...
October 16, 2018: Research in Veterinary Science
R Gálvez, A Montoya, F Fontal, L Martínez De Murguía, G Miró
Leishmaniosis caused by Leishmania infantum is a widespread zoonotic disease that can be transmitted to animals and humans by their vectors, blood-sucking phlebotomine sand flies. To prevent canine leishmaniosis across the whole Mediterranean region, vector control is essential. Because of phlebotomine breeding sites are diverse, environmental larval controls have limited practical value. Control methods of adults are being evaluated, such as selective baits based on sugar feeding of males and females or Attractive Toxic Sugar Baits (ATSB), and the indoor use of Long-Lasting-Insecticidal Nets (LLINs) treated with permethrin to prevent sand fly bites complementing the Indoor Residual Spraying (IRS) approach suggested by WHO...
October 13, 2018: Research in Veterinary Science
Danielle A Mzyk, Claire M Bublitz, Ginger D Hobgood, Marilyn N Martinez, Jennifer L Davis, Geof W Smith, Ronald E Baynes
The intent of this study was to determine what influence, if any, increasing age has on the binding of drugs to plasma proteins in cattle. Plasma from three different cohorts of calves were used. The first group (n = 20) had plasma samples taken at 1, 7 and 21 days of age. These were compared to results from a second group of calves at 8 weeks and third group sampled at 6 months of age. The plasma protein binding of danofloxacin, florfenicol, flunixin meglumine and tulathromycin was determined in vitro via microcentrifugation using three different drug concentrations spiked into the individual plasma samples derived from each calf...
October 13, 2018: Research in Veterinary Science
Julia Steinhoff-Wagner, Jason Jeremia Hayer, Celiné Heinemann
No abstract text is available yet for this article.
October 12, 2018: Research in Veterinary Science
Hirotaka Matsumoto, Takahiro Teshima, Yoshiyuki Iizuka, Arihito Sakusabe, Daiki Takahashi, Akiteru Amimoto, Hidekazu Koyama
We investigated the clinical effectiveness of subcutaneous (SC) administration of recombinant feline interferon-omega (rFeIFN-ω) at a dose of 1 M unit (MU)/kg body weight (bw) for the treatment of feline chronic gingivitis-stomatitis (FCGS) in cats infected with feline calicivirus (FCV). Among the 17 cats used in this study, there were 13 FCV-positive cats (FCVI group), which were subcutaneously injected with rFeIFN-ω. The remaining four FCV-positive cats (FCVC group) were treated with SC corticosteroid...
October 12, 2018: Research in Veterinary Science
Anuwat Wiratsudakul, Satoshi Sekiguchi
Foot-and-mouth disease (FMD) is one of the most endemic diseases in livestock worldwide. The disease occurrence generally results in a huge economic impact. The virus may distribute across countries or even continents along the contact network of animal movements. The present study, therefore, aimed to explore a cattle movement network originated in Tak, a Thailand-Myanmar bordered province and to demonstrate how FMDV spread among the nodes of market, source and destination. Subsequently, we examined the effectiveness of market closure intervention...
October 11, 2018: Research in Veterinary Science
Kinga Biernacka, Katarzyna Podgórska, Anna Tyszka, Tomasz Stadejek
Porcine reproductive and respiratory syndrome (PRRS) is one of the most common infectious diseases of swine globally. Since the course of PRRS virus (PRRSV) infection is subclinical, laboratory diagnosis is necessary to detect the virus or specific antibodies. The aim of this study was to assess the sensitivity and specificity of IDEXX PRRS X3 Ab Test (IDEXX, USA), Civtest Suis E/S (Hipra, Spain), INgezim PRRS 2.0 (Ingenasa, Spain), VetExpert PRRS Ab ELISA 4.0 (BioNote, Korea), Pigtype PRRSV Ab (Qiagen, Germany) and PrioCHECK PRRSV Antibody ELISA (ThermoFisher, USA), using serum samples obtained from 5 conventional PRRSV-positive and 5 PRRSV-negative Polish pig farms...
October 6, 2018: Research in Veterinary Science
Alex Jesús Hernández-Granados, Moisés Armides Franco-Molina, Erika Evangelina Coronado-Cerda, Pablo Zapata-Benavides, Edgar Mendoza Gamboa, Yareellys Ramos-Zayas, Silvia Elena Santana-Krímskaya, Cristina Rodríguez-Padilla
Whole tumor cell lysates consist of a mixture of tumor antigens and danger associated molecular patterns (DAMPs) that can be used for dendritic cell maturation and consequently for the activation of a polyclonal T cell-specific tumor response. We evaluated the in vitro efficacy of three different preparations of canine transmissible venereal tumor (TVT) cell lysates: hypochlorous acid-whole tumor cell lysates (HOCl-L), heat shock-whole tumor cell lysates (HS-L), and freeze-thaw cycles-whole tumor cell lysates (FT-L) for the maturation of canine-derived dendritic cells...
October 5, 2018: Research in Veterinary Science
Juliana Aparecida Cerqueira, Wilmer Alejandro Zamora Restan, Mayara Gonçalves Fonseca, Lucas Azevedo Catananti, Maria Luiza Mendes de Almeida, Walter Heinz Feringer Junior, Gener Tadeu Pereira, Aulus Cavalieri Carciofi, Guilherme de Camargo Ferraz
Few data exist on the physiological consequences of an incremental exercise test (IET) and training in dogs. Here we evaluated the effect of an endurance-training program (ETP) on the kinetics of the serum biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), myoglobin, cardiac troponin I (cTnI), and creatine kinase isoenzyme MB (CK-MB). Eighteen Beagle dogs were assigned to three groups: sedentary (S), untrained (U), and trained (T). The dogs from the groups T and U underwent IET, and their lactate threshold (LT) was determined...
October 3, 2018: Research in Veterinary Science
Lena Burri, Cathy Wyse, Stuart R Gray, William S Harris, Kali Lazzerini
A seafood-based supplement from krill, rich in omega-3 phospholipids and proteins was tested on a group of dogs competing in the 2016 Iditarod dog sled race to investigate the effects of krill meal on exercise-induced inflammation and muscle damage in comparison to a control group. A single team of 16 dogs received 8% krill meal for 5 weeks prior to the start of race, while another team of 16 dogs received no supplementation. Ten dogs of the treatment and 11 dogs of the control group finished the race and their blood was analyzed for omega-3 index, inflammation (CRP) and muscle damage (CK)...
October 3, 2018: Research in Veterinary Science
Lauren Proctor-Brown, Rebecca Hicks, Sarah Colmer, Danielle Guilfoyle, Barbara Dallap-Schaer, Amy L Johnson, Joy Tomlinson
Digital cryotherapy (DC) is frequently used as laminitis prophylaxis for horses. While DC with ice-water slurries is reported to be safe for up to 48 h, the safety of sleeve-style digital cryotherapy (SSDC) with ice in direct contact with the distal limb has not been evaluated. Our objective was to determine the incidence of distal limb pathologic conditions (DLPC) among horses treated with SSDC. A retrospective study of cases from 2011 to 2015 identified 285 horses treated with SSDC for a minimum of 12 h...
October 2, 2018: Research in Veterinary Science
María Alejandra Colombatti Olivieri, Roberto Damián Moyano, Gabriel Eduardo Traveria, María Fiorella Alvarado Pinedo, María Laura Mon, María José Gravisaco, Fernando Oscar Delgado, María Paz Santangelo, María Isabel Romano
Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include an effective vaccine. Several strategies have assessed the virulence and immune response of Map strains that could be used as a vaccine. This study evaluates the degree of virulence, immune response, and protection of Argentinian strains of Map with different genotype in a murine model...
October 2, 2018: Research in Veterinary Science
Massimo Amadori
No abstract text is available yet for this article.
October 2, 2018: Research in Veterinary Science
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