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Progress in Biophysics and Molecular Biology

Wenguang Li
Human saphenous vein has long been used as coronary artery bypass grafts to survive a heart arrested by blocked coronary arteries. Biomechanical properties of the saphenous vein can be critical because mismatch in the biomechanical property between a coronary artery and a graft will reduce graft patency and speed up disease development in the graft. In this paper hence the active and passive biomechanical behaviours of the human saphenous vein and other venous walls were reviewed extensively and comprehensively...
November 18, 2017: Progress in Biophysics and Molecular Biology
Sahar E Abo-Neima
Cancer treatment is one of the main challenges that face the scientific centers all over the world. The cancer incidence percentage increases year after year. The most used treatment for cancer is chemotherapy which is an application of systemic cytotoxic drug inside the patient. There are two main problems in chemotherapy that the cytotoxic drug is given systematically and cannot be localized in the tumor region in most cases that lead to killing the cancer cells as well as normal cells; and that cause the chemotherapy side effects like anemia, decrease in all blood cells count and platelets, nausea, vomiting, diarrhea, hair and nails loss and may cause a kind of blood toxicity...
November 14, 2017: Progress in Biophysics and Molecular Biology
Mohammad Bayat, Amarjit Virdi, Fatemehalsadat Rezaei, Sufan Chien
To compare the in vitro effectiveness of Low-Level Laser Therapy (LLLT) and Low Intensity Pulsed Ultrasound (LIPUS) on bony cells and related stem cells. In this study, we aim to systematically review the published scientific literature which explores the use of LLLT and LIPUS to biostimulate the activity or the proliferation of bony cells or stem cells in vitro. We searched the database PubMed for LLLT or LIPUS, with/without bone, osteoblast, osteocyte, stem cells, the human osteosarcoma cell line (MG63), bone-forming cells, and cell culture (or in vitro)...
November 7, 2017: Progress in Biophysics and Molecular Biology
Arturo Tozzi, James F Peters
A unifying principle underlies the organization of physical and biological systems. It relates to a well-known topological theorem which succinctly states that an activity on a planar circumference projects to two activities with "matching description" into a sphere. Here we ask: what does "matching description" mean? Has it something to do with "identity"? Going through different formulations of the principle of identity, we describe diverse possible meanings of the term "matching description". We demonstrate that the concepts of "sameness", "equality", "belonging together" stand for intertwined levels with mutual interactions...
October 31, 2017: Progress in Biophysics and Molecular Biology
Plamen L Simeonov, Arran Gare, Koichiro Matsuno, Abir U Igamberdiev, Denis Noble
No abstract text is available yet for this article.
October 30, 2017: Progress in Biophysics and Molecular Biology
Hutan Ashrafian
Several temporal paradoxes exist in physics. These include General Relativity's grandfather and ontological paradoxes and Special Relativity's Langevin-Einstein twin-paradox. General relativity paradoxes can exist due to a Gödel universe that follows Gödel's closed timelike curves solution to Einstein's field equations. A novel biological temporal paradox of General Relativity is proposed based on reproductive biology's phenomenon of heteropaternal fecundation. Herein, dizygotic twins from two different fathers are the result of concomitant fertilization during one menstrual cycle...
October 25, 2017: Progress in Biophysics and Molecular Biology
Xin Tian, Yun-Ren Qiu
Hydrophilic material 2-methoxyethylacrylate (MEA) was grafted onto polyurethane (PU) membrane via Michael addition reaction. Fourier transform infrared spectroscope (FTIR) and X-ray photoelectron spectroscopy (XPS) characterizations of the modified membrane proved that MEA had been successfully grafted onto PU membrane surface. The water contact angle of membrane materials was tested. The results showed that the water contact angle changed from 86° to 48°, which means that the hydrophilicity of the modified membrane was greatly improved...
October 24, 2017: Progress in Biophysics and Molecular Biology
Alexander Balakin, Daniil Kuznetsov, Yuri Protsenko
The main aims of adaptation mechanisms of heart contractility are to regulate the stroke volume and optimize the global heart function. These mechanisms manifest themselves in hearts of healthy animals and in hearts with severe hypertrophy in different ways. Severe right ventricle hypertrophy was induced by single treatment with monocrotaline. Young rats of both sexes were used to prevent influences of sex hormones on the development of right ventricular hypertrophy. Serial duplex method is used as a model of interaction of two ventricular wall segments...
October 16, 2017: Progress in Biophysics and Molecular Biology
Jesse Sterling Bettinger
Under a variety of conditions, non-linear systems with many degrees of freedom tend to evolve towards complexity and criticality. Over the last few decades, a steady proliferation of models re: nonlinear and far-from-equilibrium thermodynamics of metastable, many-valued systems arose, serving as attributes of a 'critical' attractor landscape. Building off recent data citing trademark aspects of criticality in the brain-including: power-laws, scale-free (1/f) behavior (scale invariance, or scale independence, critical slowing, and avalanches-it has been conjectured that operating at criticality entails functional advantages such as: optimized neural computation and information processing; memory; large dynamical ranges; long-range communication; and "enhanced ability to react to highly diverse stimuli...
October 11, 2017: Progress in Biophysics and Molecular Biology
Zhila Shaterabadi, Gholamreza Nabiyouni, Meysam Soleymani
Magnetic nanoparticles as heat generation nanosources in hyperthermia treatment are still faced with many drawbacks for achieving sufficient clinical potential. In this context, increase in heating ability of magnetic nanoparticles in a safe alternating magnetic field and also approach to a precise control on temperature rise are two challenging subjects so that a significant part of researchers' efforts has been devoted to them. Since a deep understanding of Physics concepts of heat generation by magnetic nanoparticles is essential to develop hyperthermia as a cancer treatment with non-adverse side effects, this review focuses on different mechanisms responsible for heat dissipation in a radio frequency magnetic field...
October 6, 2017: Progress in Biophysics and Molecular Biology
Alexander A Zamyatnin
Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of many oligopeptides have been identified from >2000 organisms representing all the biological kingdoms. We have considered a number of mathematical (sequence length), chemical, physical, and biological features of an array of natural oligopeptides on the basis of the oligopeptide EROP-Moscow database (, 15,351 entries) data. There is the substantial difference of these substances from polypeptide molecules of proteins according to their physicochemical characteristics...
September 30, 2017: Progress in Biophysics and Molecular Biology
Xueling He, Liang Li, Min Tang, Ye Zeng, Huiming Li, Xiaoqin Yu
Electrical conductance is one of the factors of the microenvironment of cardiomyocytes, and electrical stimulation (ES) has been shown to modulate the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) toward a cardiomyogenic fate. Transforming growth factor-beta 1 (TGF-β1) stimulates the cardiomyogenic marker expression in BMSCs. Herein, we promoted the differentiation of BMSCs into cardiomyocyte-like cells using ES to confirm if TGF-β1 mediates this event in vitro. ES increased protein levels of TGF-β1 in BMSCs, and this effect was better than that observed with 5-azacytidine (5-Aza)...
September 29, 2017: Progress in Biophysics and Molecular Biology
Ye Zeng, Jiang Wu, Xueling He, Liang Li, Xiaojing Liu, Xiaoheng Liu
Age-related diseases involving degeneration of human skeletal and cardiovascular systems are now critical problems worldwide. The current review focuses on a common pathophysiological association between primary osteoporosis and vascular calcification, and reviews the mechanical response of bone cells and vascular cells to mechanical stress, as well as the coordination mechanism for intercellular signaling. With aging, calcium is lost from bones but deposited in the cardiovascular system. Bone metabolism-related molecules, such as alkaline phosphatase, matrix Gla protein, osteocalcin, osteopontin, and collagen type I; inflammatory cytokines, such as interleukin-1, -6, and tumor necrosis factor; and lipid metabolism related molecules, such as oxidized low density lipoprotein; mediate signaling in primary osteoporosis and vascular calcification...
September 27, 2017: Progress in Biophysics and Molecular Biology
T Chen, H Zhao, L Gao, L Song, F Yang, J Du
The closure of gaps within epithelia is an essential part of many physiological and pathological processes, such as embryonic development, organ remodeling and wound healing. Emerging evidence proved that the physical microenvironment plays important roles in cell behaviors. However, the effect of osmolarity of extracellular medium on gap closure is least understood. Using a gap closure model of epithelial cells, we found that hypotonic condition significantly facilitated the process of gap closure. Moreover, instead of actomyosin ring, enhanced migration leading by lamellipodia primarily contributed to the rapid gap closure in hypotonic condition...
September 26, 2017: Progress in Biophysics and Molecular Biology
Eva A Rog-Zielinska, Remi Peyronnet
No abstract text is available yet for this article.
September 26, 2017: Progress in Biophysics and Molecular Biology
Alexey V Melkikh, Dirk K F Meijer
The current protein folding literature is reviewed. Two main approaches to the problem of folding were selected for this review: geometrical and biophysical. The geometrical approach allows the formulation of topological restrictions on folding, that are usually not taken into account in the construction of physical models. In particular, the topological constraints do not allow the known funnel-like energy landscape modeling, although most common methods of resolving the paradox are based on this method. The very paradox is based on the fact that complex molecules must reach their native conformations (complexes that result from reactions) in an exponentially long time, which clearly contradicts the observed experimental data...
September 23, 2017: Progress in Biophysics and Molecular Biology
J Christoph, J Schröder-Schetelig, S Luther
Optical mapping is a widely used imaging technique for investigating cardiac electrophysiology in intact, Langendorff-perfused hearts. Mechanical contraction of cardiac tissue, however, may result in severe motion artifacts and significant distortion of the fluorescence signals. Therefore, pharmacological uncoupling is widely used to reduce tissue motion. Recently, various image processing algorithms have been proposed to reduce motion artifacts. We will review these technological developments. Furthermore, we will present a novel approach for the three-dimensional, marker-free reconstruction of contracting Langendorff-perfused intact hearts under physiological conditions...
September 22, 2017: Progress in Biophysics and Molecular Biology
John Kineman
Whereas the last Century of science was characterized by epistemological uncertainty; the current Century will likely be characterized by ontological complexity (Gorban and Yablonsky, 2013). Advances in Systems Theory by mathematical biologist Robert Rosen suggest an elegant way forward (Rosen, 2013). "R-theory" (Kineman, 2012) is a synthesis of Rosen's theories explaining complexity and life in terms of a meta-model for 'whole' systems (and their fractions) in terms of "5(th)-order holons". Such holons are Rosen modeling relations relating system-dependent processes with their formative contexts via closed cycles of four archetypal (Aristotelian) causes...
September 21, 2017: Progress in Biophysics and Molecular Biology
Jesse S Bettinger, Timothy E Eastman
Recent advances in modern physics and biology reveal several scenarios in which top-down effects (Ellis, 2016) and anticipatory systems (Rosen, 1980) indicate processes at work enabling active modeling and inference such that anticipated effects project onto potential causes. We extrapolate a broad landscape of anticipatory systems in the natural sciences extending to computational neuroscience of perception in the capacity of Bayesian inferential models of predictive processing. This line of reasoning also comes with philosophical foundations, which we develop in terms of counterfactual reasoning and possibility space, Whitehead's process thought, and correlations with Eastern wisdom traditions...
September 21, 2017: Progress in Biophysics and Molecular Biology
Hui Zhang, Aixiang Liu, Xielin Feng, Lang Tian, Wentao Bo, Haiqing Wang, Yong Hu
MicroRNA (miRNAs) emerges as key oncogene or tumor suppressor in a variety of cancers including pancreatic carcinoma. In this study, we detected the role of miR-132 in development and progression of pancreatic cancer and the underlying mechanism. First, the expression of miR-132 in pancreatic carcinoma and adjacent non-cancerous tissues were detected by qRT-PCR. Then, the role of miR-132 in biological function of pancreatic carcinoma cells was investigated. Our results identified that miR-132 was generally upregulated in pancreatic carcinoma, and phosphatase and tensin homolog (PTEN) was generally downregulated...
September 20, 2017: Progress in Biophysics and Molecular Biology
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