journal
MENU ▼
Read by QxMD icon Read
search

Postgraduate Medicine

journal
https://www.readbyqxmd.com/read/29446691/early-insights-into-the-characteristics-and-evolution-of-clinical-parameters-in-a-cohort-of-patients-prescribed-sacubitril-valsartan-in-germany
#1
Rolf Wachter, Daniel Viriato, Sven Klebs, Stefanie S Grunow, Matthias Schindler, Johanna Engelhard, Catia C Proenca, Frederico Calado, Raymond Schlienger, Markus Dworak, Bogdan Balas, Sara Bruce Wirta
OBJECTIVES: This study aimed to provide early insights into sacubitril/valsartan (sac/val) prescription patterns and the demographic and clinical characteristics of patients prescribed sac/val in primary care and cardiology settings in Germany. METHODS: The study used electronic medical records from the German IMS® Disease Analyzer database. Patients with ≥1 prescription for sac/val during 1 January-31 December 2016 (n = 1643) were identified and followed up for ≤12 months from first prescription...
February 15, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29417856/gastrointestinal-safety-and-tolerability-of-oral-non-aspirin-over-the-counter-analgesics
#2
Nicholas Moore, James M Scheiman
Over-the-counter (OTC) analgesics are routinely used worldwide for self-management of various painful conditions. Despite this, there has been little in-depth review of the safety of non-aspirin analgesics at OTC doses. This paper reviews the available literature on the gastrointestinal (GI) and hepatic safety of non-aspirin OTC analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs; ibuprofen, ketoprofen, diclofenac, and naproxen) and acetaminophen; safety in overdose is also reviewed. Each non-aspirin OTC analgesic has a distinct adverse event (AE) profile, with GI AE rates for OTC dosing in one study ranging from 37% for diclofenac to 7...
February 8, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29415606/cutaneous-irritancy-of-an-ibuprofen-medicated-plaster-in-healthy-volunteers
#3
Manisha Maganji, Mark P Connolly, Aomesh Bhatt
OBJECTIVES: To assess the irritation and contact sensitization potential of a 200 mg ibuprofen medicated plaster. METHODS: This double-blind, phase-1 placebo controlled study had two phases; the induction phase to evaluate the irritant potential of continuous application of the plaster, and the challenge phase to assess contact sensitivity (allergy). The cumulative irritancy potential was evaluated using an adaptation of the Shelanski method. Healthy adults (≥18 years of age) (N=210) were treated simultaneously with one ibuprofen medicated and one placebo plaster applied in a randomized fashion to either the left or right side of the lower back...
February 8, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29411675/pcsk9-inhibitors-a-non-statin-cholesterol-lowering-treatment-option
#4
Gregory S Pokrywka
Elevated low-density lipoprotein cholesterol (LDL-C) plays a major role in the development of atherosclerotic cardiovascular disease. Statins are the first-line treatment to lower LDL-C in patients with hypercholesterolemia; however, some high cardiovascular risk patients may have inadequate responses to statin therapy or are intolerant to statins, and may need additional and/or alternative non-statin therapies to further reduce their LDL-C levels. Monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of circulating LDL-C levels, have received considerable attention as promising non-statin therapeutic options for the management of hypercholesterolemia...
February 7, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29405077/barriers-to-implementation-of-a-pelvic-examination-among-family-doctors-in-primary-care-clinics
#5
Nassar Saleh, Mousa Abu-Gariba, Ilan Yehoshua, Roni Peleg
OBJECTIVE: Although the pelvic examination of female patients should be an integral part of the physical examination in family medicine there are many barriers to the conduct of this intimate examination by family doctors. THE OBJECTIVE: an assessment of the attitudes and barriers reported by family doctors on conducting a pelvic examination. METHODS: An anonymous, self-administered questionnaire. RESULTS: Two hundred thirty doctors participated in the study, of who 157 were males (68...
February 6, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29388462/safety-and-tolerability-of-new-generation-anti-obesity-medications-a-narrative-review
#6
Dhiren K Patel, Fatima Cody Stanford
The prevalence of obesity and associated comorbidities is rising. Despite their weight-loss efficacy, new generation anti-obesity medications are only prescribed to a minority of adults with obesity, possibly, which in part may be due to safety concerns. This review presents detailed safety profiles for orlistat, phentermine/topiramate, lorcaserin, naltrexone/bupropion and liraglutide 3.0 mg, and discusses the associated risk-benefit profiles. Two anti-obesity medications presented safety issues that warranted further discussion; phentermine/topiramate (fetal toxicity) and liraglutide 3...
February 1, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29375010/aggressive-systolic-blood-pressure-control-in-older-subjects-benefits-and-risks
#7
Steven G Chrysant
Systolic hypertension, especially isolated systolic hypertension (ISH) is very common in older subjects aged ≥ 65 years and is a major risk factor for cardiovascular disease (CVD), strokes, heart failure (HF) and chronic kidney disease (CKD). It is also, directly and linearly related with these complications irrespective of sex, or ethnicity, but it is worse with the advancement of age. Effective control of systolic blood pressure (SBP), is associated with significant reduction in the incidence of these complications...
February 1, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29380646/a-simple-risk-score-based-on-sleep-quality-for-predicting-depressive-symptoms-in-menopausal-women-a-multicenter-study
#8
Yanwei Zheng, Yang Zhou, Jieping Zhu, Qi Hua, Minfang Tao
OBJECTIVE: We aim to establish a simple risk score based on sleep quality for predicting depressive symptoms in menopausal women through a cross-sectional investigation. MATERIALS AND METHODS: A total of 705 Chinese women aged 40-60 years were included in this cross-sectional investigation of a self-report questionnaire from the Physical Examination Center at Shanghai Jiao Tong University Affiliated Sixth People's Hospital. Depressive symptoms and sleep quality were evaluated using self-rating depressive symptom scale (SDS)and the Pittsburgh Sleep Quality Index (PSQI), respectively...
January 30, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29369696/disease-or-adaptation-another-look-at-the-practice-of-medicine
#9
Peter B Soeters, Peter W de Leeuw
The practice of medicine has changed considerably over the past few decades and is now focusing more and more on early intervention strategies. As a result, we tend to consider pre-symptomatic abnormalities, however small, already as a potential target for treatment. In this viewpoint, we argue that we should put more emphasis on pathophysiological thinking as many of the so-called early abnormalities may, in fact, reflect adaptive mechanisms rather than disease. This view should influence medical care and education, emphasizing the importance of knowledge of pathophysiology...
January 25, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29350578/the-impact-of-gender-on-asthma-in-the-daily-clinical-practice
#10
Giorgio Ciprandi, Fabio Gallo
OBJECTIVES: It is up-to-date to consider the potential gender impact on a disease. There are few data about gender difference in asthma. Therefore, the present cross-sectional study tested this hypothesis in a real-life setting to investigate possible difference between genders. METHODS: This study was cross-sectional, considering 554 consecutive outpatients suspected of asthma, who were referred for a first specialist visit. Clinical and functional parameters were evaluated...
January 19, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29350569/practice-pearl-liraglutide-and-cardiovascular-and-renal-events-in-type-2-diabetes
#11
Robert Guthrie
Review of: Marso S, Daniels G, Brown-Frandsen K, et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2016; 375: 311-322. Mann J, Orsted D, Brown-Frandsen K, et al. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med 2017; 377: 839-848. This comprehensive research project, LEADER, led to two reports, one focusing on the effect of liraglutide on cardiovascular events, and the second one reporting on the renal effects on the same study population. The study group included 9340 patients with type 2 diabetes...
January 19, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29297732/canagliflozin-and-cardiovascular-and-renal-events-in-type-2-diabetes
#12
Robert Guthrie
Review of: Neal B, Perkovic V, Mahaffey K, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med 2017: 377; 644-657. The report combines the data from two trials, CANVAS and CANVAS-Renal, which were designed to evaluate the safety and effect of canagliflozin, an SGLT-2 inhibitor, on the appearance of cardiovascular and renal events in patients with type 2 diabetes. Enrollees were patients with type 2 diabetes of at least 30 years of age, with a glycated hemoglobin of > or equal to 7...
January 3, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29291669/cultural-primer-for-cardiometabolic-health-health-disparities-structural-factors-community-pathways-to-improvement-and-clinical-applications
#13
Richard Kones, Umme Rumana
The quest to optimize cardiometabolic health has created great interest in nonmedical health variables in the population, community-based research and coordination, and addressing social, ethnic, and cultural barriers. All of these may be of equal or even greater importance than classical health care delivery in achieving individual well-being. One dominant issue is health disparity - causes, methods of reduction, and community versus other levels of solutions. This communication summarizes some major views regarding social structures, followed by amplification and synthesis of central ideas in the literature...
January 2, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29291638/changes-in-patient-characteristics-glucose-lowering-treatment-glycemic-control-and-complications-in-type-2-diabetes-in-general-practices-disease-analyzer-germany-2008-2016
#14
Wolfgang Rathmann, Markus Scheerer, Katja Rohwedder, Stefan Busch, Karel Kostev
OBJECTIVES: The objectives were to examine long-term changes in type 2 diabetes patient characteristics, diabetes treatment, control and complications in general practices. METHODS: All type 2 diabetes patients were identified in a representative general practice database (Disease Analyser, Germany) in three periods (01/2008-12/2008: n = 90.866, 818 practices, mean age (SD): 67.6 (12.1) years, 51% males; 01/2012-12/2012: n = 179.923, 1.158 practices, 68.3 (12...
January 1, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29260929/switching-basal-insulins-in-type-2-diabetes-practical-recommendations-for-health-care-providers
#15
Sarah L Anderson, Jennifer M Trujillo, John E Anderson, Robert J Tanenberg
Basal insulin remains the mainstay of treatment of type 2 diabetes when diet changes and exercise in combination with oral drugs and other injectable agents are not sufficient to control hyperglycemia. Insulin therapy should be individualized, and several factors influence the choice of basal insulin; these include pharmacological properties, patient preferences, and lifestyle, as well as health insurance plan formularies. The recent availability of basal insulin formulations with longer durations of action has provided further dosing flexibility; however, patients may need to switch agents throughout therapy for a variety of personal, clinical, or economic reasons...
December 20, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29257721/sarcoidosis-presenting-with-acute-dacryoadenitis
#16
Manuel Roca, Gerardo Moro, Ricardo Broseta, Bernardino Roca
Sarcoidosis is a systemic inflammatory disorder, pathologically characterized by noncaseating epithelioid granulomas. We report a case of the disease that presented with acute dacryoadenitis followed by acute parotitis.
December 19, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29231065/serum-interleukin-6-levels-as-an-indicator-of-aseptic-meningitis-among-children-with-enterovirus-71-induced-hand-foot-and-mouth-disease
#17
Joo Young Lee, Minji Son, Jin Han Kang, Ui Yoon Choi
OBJECTIVES: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. It is often performed based on physicians' clinical suspicion. A diagnostic method that can aid in deciding whether this procedure should be performed is necessary. Cytokines are speculated to be associated with neurologic complications...
December 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29210318/inhalation-device-options-for-the-management-of-chronic-obstructive-pulmonary-disease
#18
Michael DePietro, Ileen Gilbert, Lauren A Millette, Michael Riebe
Chronic obstructive pulmonary disease (COPD) is characterized by chronic respiratory symptoms and airflow limitation, resulting from abnormalities in the airway and/or damage to the alveoli. Primary care physicians manage the healthcare of a large proportion of patients with COPD. In addition to determining the most appropriate medication regimen, which usually includes inhaled bronchodilators with or without inhaled corticosteroids, physicians are charged with optimizing inhalation device selection to facilitate effective drug delivery and patient adherence...
December 5, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29202670/cardiovascular-safety-of-non-steroidal-anti-inflammatory-drugs-revisited
#19
Chris Walker, Luigi M Biasucci
Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used to treat inflammatory pain for decades. More recently, newer NSAIDs were developed to target the inducible isoform of cyclooxygenase (COX), COX-2, with the aim of reducing gastrointestinal toxicity. While the COX-2 selective inhibitors were effective in reducing pain and gastrointestinal harm, they soon were associated with an increased risk of adverse cardiovascular events. Initially, the view emerged that selective inhibition of COX-2, and sparing of COX-1, was responsible for the increased cardiovascular harm observed...
December 5, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29202631/vaping-medical-marijuana
#20
Devina Singh, Steven Lippmann
No abstract text is available yet for this article.
December 5, 2017: Postgraduate Medicine
journal
journal
24173
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"