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Parasitology

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https://www.readbyqxmd.com/read/28077187/lysosome-like-compartments-of-trypanosoma-cruzi-trypomastigotes-may-originate-directly-from-epimastigote-reservosomes
#1
Juliana C Vidal, Carolina DE L Alcantara, Wanderley DE Souza, Narcisa L Cunha-E-Silva
Trypanosoma cruzi epimastigote reservosomes store nutrients taken up during the intense endocytic activity exhibited by this developmental form. Reservosomes were classified as pre-lysosomal compartments. In contrast, trypomastigote forms are not able to take up nutrients from the medium. Interestingly, trypomastigotes also have acidic organelles with the same proteases contained in epimastigote reservosomes. Nevertheless, the origin and function of these organelles have not been disclosed so far. Given the similarities between the compartments of epimastigotes and trypomastigotes, the present study aimed to investigate the origin of metacyclic trypomastigote protease-containing organelles by tracking fluorospheres or colloidal gold particles previously stored in epimastigotes' reservosomes throughout metacyclogenesis...
January 12, 2017: Parasitology
https://www.readbyqxmd.com/read/28077183/the-prevalence-of-aphanomyces-astaci-in-invasive-signal-crayfish-from-the-uk-and-implications-for-native-crayfish-conservation
#2
J James, S Nutbeam-Tuffs, J Cable, A Mrugała, N Viñuela-Rodriguez, A Petrusek, B Oidtmann
The crayfish plague agent, Aphanomyces astaci, has spread throughout Europe, causing a significant decline in native European crayfish. The introduction and dissemination of this pathogen is attributed to the spread of invasive North American crayfish, which can act as carriers for A. astaci. As native European crayfish often succumb to infection with A. astaci, determining the prevalence of this pathogen in non-native crayfish is vital to prioritize native crayfish populations for managed translocation. In the current study, 23 populations of invasive signal crayfish (Pacifastacus leniusculus) from the UK were tested for A...
January 12, 2017: Parasitology
https://www.readbyqxmd.com/read/28077180/understanding-transmissibility-patterns-of-chagas-disease-through-complex-vector-host-networks
#3
Laura Rengifo-Correa, Christopher R Stephens, Juan J Morrone, Juan Luis Téllez-Rendón, Constantino González-Salazar
Chagas disease is one of the most important vector-borne zoonotic diseases in Latin America. Control strategies could be improved if transmissibility patterns of its aetiologic agent, Trypanosoma cruzi, were better understood. To understand transmissibility patterns of Chagas disease in Mexico, we inferred potential vectors and hosts of T. cruzi from geographic distributions of nine species of Triatominae and 396 wild mammal species, respectively. The most probable vectors and hosts of T. cruzi were represented in a Complex Inference Network, from which we formulated a predictive model and several associated hypotheses about the ecological epidemiology of Chagas disease...
January 12, 2017: Parasitology
https://www.readbyqxmd.com/read/28073394/gregarine-infection-accelerates-larval-development-of-the-cat-flea-ctenocephalides-felis-bouch%C3%A3
#4
M E Alarcón, A Jara-F, R C Briones, A K Dubey, C H Slamovits
A high degree of specialization between host and parasite is a well-known outcome of a long history of coevolution, and it is strikingly illustrated in a coordination of their life cycles. In some cases, the arms race ensued at the establishment of a symbiotic relationship results in the adoption of manipulative strategies by the parasite. We have already learned that Steinina ctenocephali, a gregarine living in the alimentary canal of cat flea, Ctenocephalides felis follows its phenology and metamorphosis...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073393/study-on-the-mitochondrial-apoptosis-pathways-of-small-cell-lung-cancer-h446-cells-induced-by-trichinella-spiralis-muscle-larvae-esps
#5
Jingmei Luo, L I Yu, Guangcheng Xie, Dan Li, Meng Su, Xuerong Zhao, Luanying DU
Trichinella spiralis (T.spiralis) muscle-larva (ML) excretory-secretory proteins (ESPs) contain antitumour-active substances. ESPs have been shown to inhibit tumour growth. To explore the effects of these proteins on small cell lung cancer cells and the possible mechanisms of their antineoplastic action, H446 SCLC cells were co-cultured with different concentrations of T. spiralis ML ESPs for 12, 24 and 48 h. Our results showed that T. spiralis ML ESPs significantly inhibited H446 cell proliferation, which was dose-and time-dependent...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073392/does-the-dilution-effect-generally-occur-in-animal-diseases
#6
Zheng Y X Huang, Yang Yu, Frank VAN Langevelde, Willem F DE Boer
The dilution effect (DE) has been reported in many diseases, but its generality is still highly disputed. Most current criticisms of DE are related to animal diseases. Particularly, some critical studies argued that DE is less likely to occur in complex environments. Here our meta-analyses demonstrated that the magnitude of DE did not differ between animal vs plant diseases. Moreover, DE generally occurs in all three subgroups of animal diseases, namely direct-transmitted diseases, vector-borne diseases and diseases caused by parasites with free-living stages...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073389/the-distribution-of-echinostome-parasites-in-ponds-and-implications-for-larval-anuran-survival
#7
John A Marino, Manja P Holland, Earl E Werner
Parasites can influence host population dynamics, community composition and evolution. Prediction of these effects, however, requires an understanding of the influence of ecological context on parasite distributions and the consequences of infection for host fitness. We address these issues with an amphibian - trematode (Digenea: Echinostomatidae) host-parasite system. We initially performed a field survey of trematode infection in first (snail) and second (larval green frog, Rana clamitans) intermediate hosts over 5 years across a landscape of 23 ponds in southeastern Michigan...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073388/isolation-and-biological-and-molecular-characterization-of-neospora-caninum-nc-sp1-from-a-naturally-infected-adult-asymptomatic-cattle-bos-taurus-in-the-state-of-s%C3%A3-o-paulo-brazil
#8
Solange Oliveira, Rodrigo Martins Soares, Juliana Aizawa, Herbert Sousa Soares, Daniela Pontes Chiebao, Luis Miguel Ortega-Mora, Javier Regidor-Cerrillo, Natália Quadros Bressa Silva, Solange Maria Gennari, Hilda Fátima Jesus Pena
The biological and genetic diversity of Neospora caninum is very limited because of availability of only a few viable isolates worldwide. This study describes the isolation and biological and molecular characterization of a new viable isolate of N. caninum (NC-SP1), from a cattle in Brazil. Approximately 400 g of brain from a naturally infected adult male cattle from an abattoir was fed to a 2-month-old dog. Neospora-like oocysts were observed on day 7 post-inoculation (PI) and the duration of oocyst shedding was 14 days...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073385/the-cestode-parasite-schistocephalus-pungitii-castrator-or-nutrient-thief-of-ninespine-stickleback-fish
#9
David C Heins
In this investigation, the host-parasite relationship of ninespine stickleback fish Pungitius pungitius and the cestode parasite Schistocephalus pungitii was studied using samples from Dog Bone Lake, Kenai Peninsula, Alaska, to test the hypothesis that S. pungitii is a castrator of ninespine stickleback. Infected, adult females of all sizes (ages) were capable of producing clutches of eggs. S. pungitii had a negative effect on the ability of host females to produce a clutch, which was related to increasing parasite:host mass ratio (parasite index, PI)...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073384/do-blood-parasites-infect-magellanic-penguins-spheniscus-magellanicus-in-the-wild-prospective-investigation-and-climatogeographic-considerations
#10
Ralph Eric Thijl Vanstreels, Marcela Uhart, Virginia Rago, Renata Hurtado, Sabrina Epiphanio, José Luiz Catão-Dias
Magellanic penguins (Spheniscus magellanicus) are native to Argentina, Chile and the Falkland Islands. Magellanic penguins are highly susceptible to blood parasites such as the mosquito-borne Plasmodium spp., which have been documented causing high morbidity and mortality in zoos and rehabilitation centres. However, to date no blood parasites have been detected in wild Magellanic penguins, and it is not clear whether this is reflective of their true absence or is instead related to an insufficiency in sampling effort or a failure of the diagnostic methods...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073383/evaluation-of-methylene-blue-pyrimethamine-and-its-combination-on-an-in-vitro-neospora-caninum-model
#11
Luiz Miguel Pereira, Isabel Cristina Vigato-Ferreira, Gabriela DE Luca, Cássia Mariana Bronzon DA Costa, Ana Patrícia Yatsuda
Neospora caninum is an apicomplexan parasite strongly related to reproductive problems in cattle. The neosporosis control is not well established and several fronts are under development, predominantly based on immune protection, immunomodulation and chemotherapy. The use of anti-malarial drugs as therapeutic sources has, in theory, considerable potential for any apicomplexan. Drugs such as methylene blue (MB) and pyrimethamine (Pyr) represent therapeutic options for malaria; thus, their use for neosporosis should be assessed...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073382/a-retrospective-study-comparing-agar-plate-culture-indirect-immunofluorescence-and-real-time-pcr-for-the-diagnosis-of-strongyloides-stercoralis-infection
#12
Dora Buonfrate, Francesca Perandin, Fabio Formenti, Zeno Bisoffi
Strongyloides stercoralis is a parasite that can cause death in immunocompromised people. A proper diagnosis is hence essential. The real-time polymerase-chain reaction (RT-PCR) is a novel, promising diagnostic method, that detects the DNA of the parasite in stool samples. In this retrospective study, we compared the sensitivity of agar plate coproculture (APC), an in-house immunofluorescence test (IFAT) and an in-house RT-PCR for the diagnosis of S. stercoralis infection. The study sample was composed by 223 samples...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28073381/immediate-and-lag-effects-of-pesticide-exposure-on-parasite-resistance-in-larval-amphibians
#13
Katherine M Pochini, Jason T Hoverman
Across host-parasite systems, there is evidence that pesticide exposure increases parasite loads and mortality following infection. However, whether these effects are driven by reductions in host resistance to infection or slower rates of parasite clearance is often unclear. Using controlled laboratory experiments, we examined the ability of larval northern leopard frogs (Lithobates pipiens) and American toads (Anaxyrus americanus) to resist and clear trematode (Echinoparyphium sp.) infections following exposure to the insecticide carbaryl...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28069101/immune-responses-in-mice-vaccinated-with-a-dna-vaccine-expressing-serine-protease-like-protein-from-the-new-born-larval-stage-of-trichinella-spiralis
#14
Jing Xu, Xue Bai, Li Bo Wang, Hai Ning Shi, Joke W B VAN DER Giessen, Pascal Boireau, Ming Yuan Liu, Xiao Lei Liu
Trichinella spiralis is a parasitic helminth that can infect almost all mammals, including humans. Trichinella spiralis infection elicits a typical type 2 immune responses, while suppresses type 1 immune responses, which is in favour of their parasitism. DNA vaccines have been shown to be capable of eliciting balanced CD4+ and CD8+ T cell responses as well as humoral immune responses in small-animal models, which will be advantage to induce protective immune response against helminth infection. In this study, serine protease (Ts-NBLsp) was encoded by a cDNA fragment of new-born T...
January 10, 2017: Parasitology
https://www.readbyqxmd.com/read/28031079/oligopeptidase-b-and-b2-comparative-modelling-and-virtual-screening-as-searching-tools-for-new-antileishmanial-compounds
#15
Ana Carolina R Sodero, Ana Carolina G O Dos Santos, Juliana F R E Mello, Jéssica B DE Jesus, Alessandra M T DE Souza, Maria Isabel C Rodrigues, Salvatore G DE Simone, Carlos R Rodrigues, Herbert L DE Matos Guedes
Leishmaniasis are diseases caused by parasites of the genus Leishmania and transmitted to humans by the bite of infected insects of the subfamily Phlebotominae. Current drug therapy shows high toxicity and severe adverse effects. Recently, two oligopeptidases (OPBs) were identified in Leishmania amazonensis, namely oligopeptidase B (OPB) and oligopeptidase B2 (OPB2). These OPBs could be ideal targets, since both enzymes are expressed in all parasite lifecycle and were not identified in human. This work aimed to identify possible dual inhibitors of OPB and OPB2 from L...
December 29, 2016: Parasitology
https://www.readbyqxmd.com/read/27998321/rhipicephalus-turanicus-a-new-vector-of-hepatozoon-canis
#16
Alessio Giannelli, Riccardo Paolo Lia, Giada Annoscia, Canio Buonavoglia, Eleonora Lorusso, Filipe Dantas-Torres, Gad Baneth, Domenico Otranto
The distribution of Hepatozoon canis mainly encompasses areas where its main tick vector, Rhipicephalus sanguineus sensu lato, is present. However, the detection of this pathogen in dogs, foxes and golden jackals well outside the areas inhabited by this tick species reinforced the hypothesis that additional ixodids are involved in the life cycle and transmission of this protozoon. The present study provides, for the first time, data supporting the sporogonic development of H. canis in specimens of Rhipicephalus turanicus collected from a naturally infected fox from southern Italy...
December 21, 2016: Parasitology
https://www.readbyqxmd.com/read/27976601/an-appraisal-of-the-taxonomy-and-nomenclature-of-trypanosomatids-presently-classified-as-leishmania-and-endotrypanum
#17
O A Espinosa, M G Serrano, E P Camargo, M M G Teixeira, J J Shaw
We propose a taxonomic revision of the dixenous trypanosomatids currently classified as Endotrypanum and Leishmania, including parasites that do not fall within the subgenera L. (Leishmania) and L. (Viannia) related to human leishmaniasis or L. (Sauroleishmania) formed by leishmanias of lizards: L. colombiensis, L. equatorensis, L. herreri, L. hertigi, L. deanei, L. enriettii and L. martiniquensis. The comparison of these species with newly characterized isolates from sloths, porcupines and phlebotomines from central and South America unveiled new genera and subgenera supported by past (RNA PolII gene) and present (V7V8 SSU rRNA, Hsp70 and gGAPDH) phylogenetic analyses of the organisms...
December 15, 2016: Parasitology
https://www.readbyqxmd.com/read/27976597/mycobacterial-cell-wall-biosynthesis-a-multifaceted-antibiotic-target
#18
Katherine A Abrahams, Gurdyal S Besra
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized as a global health emergency as promoted by the World Health Organization. Over 1 million deaths per year, along with the emergence of multi- and extensively-drug resistant strains of Mtb, have triggered intensive research into the pathogenicity and biochemistry of this microorganism, guiding the development of anti-TB chemotherapeutic agents. The essential mycobacterial cell wall, sharing some common features with all bacteria, represents an apparent 'Achilles heel' that has been targeted by TB chemotherapy since the advent of TB treatment...
December 15, 2016: Parasitology
https://www.readbyqxmd.com/read/27974063/leishmaniasis-and-various-immunotherapeutic-approaches
#19
Y Taslimi, F Zahedifard, S Rafati
Leishmaniasis is a vector-borne infectious disease caused by multiple Leishmania (L.) species with diverse clinical manifestations. There is currently no vaccine against any form of the disease approved in humans, and chemotherapy is the sole approach for treatment. Unfortunately, treatment options are limited to a small number of drugs, partly due to high cost and significant adverse effects. The other obstacle in leishmaniasis treatment is the potential for drug resistance, which has been observed in multiple endemic countries...
December 15, 2016: Parasitology
https://www.readbyqxmd.com/read/27974059/the-diversity-and-evolution-of-nematodes-pharyngodonidae-infecting-new-zealand-lizards
#20
Sarah Mockett, Trent Bell, Robert Poulin, Fátima Jorge
Host-parasite co-evolutionary studies can shed light on diversity and the processes that shape it. Molecular methods have proven to be an indispensable tool in this task, often uncovering unseen diversity. This study used two nuclear markers (18S rRNA and 28S rRNA) and one mitochondrial (cytochrome oxidase subunit I) marker to investigate the diversity of nematodes of the family Pharyngodonidae parasitizing New Zealand (NZ) lizards (lygosomine skinks and diplodactylid geckos) and to explore their co-evolutionary history...
December 15, 2016: Parasitology
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