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Neurologia Medico-chirurgica

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https://www.readbyqxmd.com/read/27725524/phase-i-ii-study-of-temozolomide-plus-nimustine-chemotherapy-for-recurrent-malignant-gliomas-kyoto-neuro-oncology-group
#1
Tomokazu Aoki, Yoshiki Arakawa, Tetsuya Ueba, Masashi Oda, Namiko Nishida, Yukinori Akiyama, Tetsuya Tsukahara, Koichi Iwasaki, Nobuhiro Mikuni, Susumu Miyamoto
The objective of this phase I/II study was to examine the efficacy and toxicity profile of temozolomide (TMZ) plus nimustine (ACNU). Patients who had received a standard radiotherapy with one or two previous chemo-regimens were enrolled. In phase I, the maximum-tolerated dose (MTD) by TMZ (150 mg/m(2)/day) (Day 1-5) plus various doses of ACNU (30, 35, 40, 45 mg/m(2)/day) (Day 15) per 4 weeks was defined on a standard 3 + 3 design. In phase II, these therapeutic activity and safety of this regimen were evaluated...
October 11, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27725523/an-assessment-of-the-medial-angle-of-inserted-subaxial-cervical-pedicle-screw-during-surgery-practical-use-of-preoperative-ct-scanning-and-intraoperative-x-rays
#2
Hong Bum Kim, Moon Kyu Lee, Young-Seok Lee, Jun-Young Sohn, Sang Ku Jung, Jin Hoon Park
The most important factor for cervical pedicle screw placement (CPS) is creating a sufficient medial angle. We aimed to know the medial angle of the inserted subaxial CPS during surgery using intraoperative AP X-rays. From March 2012 to September 2014, we performed posterior cervical fusions using CPS on 75 patients, including a total of 389 CPS insertions. Using preoperative CT scanning, we determined the θlat (i.e., an angle between a vertical line and a line to connect the planned entry point and the axial middle point of the pedicle) and θmed (i...
October 11, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27725522/treatment-result-in-the-initial-stage-of-kanazawa-mobile-embolectomy-team-for-acute-ischemic-stroke
#3
Naoyuki Uchiyama, Kouichi Misaki, Masanao Mohri, Tomoya Kamide, Yuichi Hirota, Ryo Higashi, Hisato Minamide, Yukihiko Kohda, Takashi Asahi, Katsuo Shoin, Masayuki Iwato, Daisuke Kita, Yoshitaka Hamada, Yuya Yoshida, Mitsutoshi Nakada
Five recent multicenter randomized controlled trials (RCTs) have clearly shown the superiority of mechanical thrombectomy in large vessel occlusion acute ischemic stroke compared to systemic thrombolysis. Although 14 hospitals in Ishikawa prefecture have uninterrupted availability of systemic thrombolysis, mechanical thrombectomy is not available at all of these hospitals. Therefore, we established a Kanazawa mobile embolectomy team (KMET), which could travel to these hospitals and perform the acute reperfusion therapy...
October 11, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27666154/national-registry-of-designated-intractable-diseases-in-japan-present-status-and-future-prospects
#4
Yasuhiro Kanatani, Naoko Tomita, Yoko Sato, Akiko Eto, Hiroe Omoe, Hiroshi Mizushima
Japan promotes research related to intractable diseases and financially supports patients with these diseases. Intractable diseases are designated as those that fulfill the following criteria: (1) rarity (affecting less than 0.1% of the population in Japan), (2) unknown etiology, (3) lack of effective treatment, (4) necessity of long-term treatment, and (5) existence of objective diagnostic criteria and not necessarily equal to rare diseases in other countries. The construction of a national database is required to promote research to clarify the pathogenesis of these diseases and to develop pharmaceutical products and medical devices...
September 21, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27646010/infiltrated-embolization-of-meningioma-with-dilute-cyanoacrylate-glue
#5
Hiroyuki Ohnishi, Shigeru Miyachi, Kenichi Murao, Ryo Hiramatsu, Kenkichi Takahashi, Hideyuki Ohnishi, Toshihiko Kuroiwa
We describe the efficacy and technical aspects of infiltrated preoperative embolization of meningioma by penetration of very dilute glue. In this method, a 13% n-butyl-cyanoacrylate (NBCA)-lipiodol mixture is injected extremely slowly from the middle meningeal artery (MMA) in a similar manner to plug and push injection of ethylene vinyl alcohol copolymer mixed with tantalum and dimethyl sulfoxide (Onyx(®)) after the tortuous side feeders are proximally embolized. The glue is infiltrated into small tumor arteries and extends to inaccessible feeders from deep meningeal arteries...
September 16, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27680330/status-and-future-perspectives-of-utilizing-big-data-in-neurosurgical-and-stroke-research
#6
Ataru Nishimura, Kunihiro Nishimura, Akiko Kada, Koji Iihara
The management, analysis, and integration of Big Data have received increasing attention in healthcare research as well as in medical bioinformatics. The J-ASPECT study is the first nationwide survey in Japan on the real-world setting of stroke care using data obtained from the diagnosis procedure combination-based payment system. The J-ASPECT study demonstrated a significant association between comprehensive stroke care (CSC) capacity and the hospital volume of stroke interventions in Japan; further, it showed that CSC capabilities were associated with reduced in-hospital mortality rates...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27680329/current-trends-and-healthcare-resource-usage-in-the-hospital-treatment-of-primary-malignant-brain-tumor-in-japan-a-national-survey-using-the-diagnostic-procedure-combination-database-j-aspect-study-brain-tumor
#7
Koji Yoshimoto, Akiko Kada, Daisuke Kuga, Ryusuke Hatae, Hideki Murata, Yojiro Akagi, Kunihiro Nishimura, Ryota Kurogi, Ataru Nishimura, Nobuhiro Hata, Masahiro Mizoguchi, Tetsuro Sayama, Koji Iihara
We conducted this study to clarify the current trends and healthcare resource usage in the treatment of inpatients with primary malignant brain tumors. The Diagnostic Procedure Combination (DPC) data of all inpatients treated between 2013 and 2014 in the 370 core and branch hospitals enrolled in the Japanese Neurosurgical Society training program were collected. DPC is a discharge abstract and administrative claims database of inpatients. We assessed 6,142 primary, malignant brain tumor patients. Patient information, diagnostic information, treatment procedure, and healthcare resource usage were analyzed...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27666343/combination-of-palonosetron-aprepitant-and-dexamethasone-effectively-controls-chemotherapy-induced-nausea-and-vomiting-in-patients-treated-with-concomitant-temozolomide-and-radiotherapy-results-of-a-prospective-study
#8
Masahide Matsuda, Tetsuya Yamamoto, Eiichi Ishikawa, Hiroyoshi Akutsu, Shingo Takano, Akira Matsumura
Concomitant use of temozolomide (TMZ) and radiotherapy, which is the standard therapy for patients with high-grade glioma, involves a unique regimen with multiple-day, long-term administration. In a previous study, we showed not only higher incidence rates of chemotherapy-induced nausea and vomiting (CINV) during the overall study period, but also substantially higher incidence rates of moderate/severe nausea and particularly severe appetite suppression during the late phase of the treatment. Here, we prospectively evaluated the efficacy of a combination of palonosetron, aprepitant, and dexamethasone for CINV in patients treated with concomitant TMZ and radiotherapy...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27616319/enhancing-neurosurgical-education-in-low-and-middle-income-countries-current-methods-and-new-advances
#9
Kevin E Liang, Ilia Bernstein, Yoko Kato, Takeshi Kawase, Mojgan Hodaie
Low- and middle-income countries (LMICs) face a critical shortage of basic surgical services. Adequate neurosurgical services can have a far-reaching positive impact on society's health care and, consequently, the economic development in LMICs. Yet surgery, and specifically neurosurgery has been a long neglected sector of global health. This article reviews the current efforts to enhance neurosurgery education in LMICs and outlines ongoing approaches for improvement. In addition, we introduce the concept of a sustainable and cost-effective model to enhance neurosurgical resources in LMICs and describe the process and methods of online curriculum development...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27302300/working-conditions-and-lifestyle-of-female-surgeons-affiliated-to-the-japan-neurosurgical-society-findings-of-individual-and-institutional-surveys
#10
Takamitsu Fujimaki, Soichiro Shibui, Yoko Kato, Akira Matsumura, Mami Yamasaki, Isao Date, Kazuhiro Hongo, Satoshi Kuroda, Mitsunori Matsumae, Naoyuki Nakao, Kaori Sakurada, Shoko Shimokawa, Takamasa Kayama
To investigate the working conditions of female neurosurgeons in Japan, two surveys were conducted by The Japan Neurosurgical Society: one involving female neurosurgeons themselves and the other involving the chiefs of neurosurgical departments. The responses were received from 224 (43.8%) female neurosurgeons and 496 (61.2%) departmental chiefs. About half (50.2%) of the female neurosurgeons were married and 39.2% had children (average number of children, 1.27). Their work was full-time in 80.6% of cases; on average, they worked 51...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27250817/critical-neural-networks-in-awake-surgery-for-gliomas
#11
Masashi Kinoshita, Katsuyoshi Miyashita, Taishi Tsutsui, Takuya Furuta, Mitsutoshi Nakada
From the embarrassing character commonly infiltrating eloquent brain regions, the surgical resection of glioma remains challenging. Owing to the recent development of in vivo visualization techniques for the human brain, white matter regions can be delineated using diffusion tensor imaging (DTI) as a routine clinical practice in neurosurgery. In confirmation of the results of DTI tractography, a direct electrical stimulation (DES) substantially influences the investigation of cortico-subcortical networks, which can be identified via specific symptoms elicited in the concerned white matter tracts (eg...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27250575/verbal-dominant-memory-impairment-and-low-risk-for-post-operative-memory-worsening-in-both-left-and-right-temporal-lobe-epilepsy-associated-with-hippocampal-sclerosis
#12
Amr Farid Khalil, Masaki Iwasaki, Yoshiyuki Nishio, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga
Post-operative memory changes after temporal lobe surgery have been established mainly by group analysis of cognitive outcome. This study investigated individual patient-based memory outcome in surgically-treated patients with mesial temporal lobe epilepsy (TLE). This study included 84 consecutive patients with intractable TLE caused by unilateral hippocampal sclerosis (HS) who underwent epilepsy surgery (47 females, 41 left [Lt] TLE). Memory functions were evaluated with the Wechsler Memory Scale-Revised before and at 1 year after surgery...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27238212/molecular-classification-of-medulloblastoma
#13
Noriyuki Kijima, Yonehiro Kanemura
Medulloblastoma (MB) is one of the most frequent malignant brain tumors in children. The current standard treatment regimen consists of surgical resection, craniospinal irradiation, and adjuvant chemotherapy. Although these treatments have the potential to increase the survival of 70-80% of patients with MB, they are also associated with serious treatment-induced morbidity. The current risk stratification of MB is based on clinical factors, including age at presentation, metastatic status, and the presence of residual tumor following resection...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27627857/non-invasive-evaluation-for-epilepsy-surgery
#14
Masaki Iwasaki, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga
Epilepsy surgery is aimed to remove the brain tissues that are indispensable for generating patient's epileptic seizures. There are two purposes in the pre-operative evaluation: localization of the epileptogenic zone and localization of function. Surgery is planned to remove possible epileptogenic zone while preserving functional area. Since no single diagnostic modality is superior to others in identifying and localizing the epileptogenic zone, multiple non-invasive evaluations are performed to estimate the location of the epileptogenic zone after concordance between evaluations...
October 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27616320/interactive-bio-feedback-therapy-using-hybrid-assistive-limbs-for-motor-recovery-after-stroke-current-practice-and-future-perspectives
#15
Takashi Morishita, Tooru Inoue
Interactive bio-feedback (iBF) was initially developed for the rehabilitation of motor function in patients with neurological disorders, and subsequently yielded the development of the hybrid assistive limb (HAL). Here, we provide a review of the theory underlying HAL treatment as well as our clinical experience and recommendations for future clinical studies using HAL in acute stroke patients. We performed a PubMed-based literature search, a retrospective data review of our acute stroke case series, and included a sample case report of our findings...
October 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27580931/nonconvulsive-status-epilepticus-in-the-neurosurgical-setting
#16
Yuichi Kubota, Hidetoshi Nakamoto, Takakazu Kawamata
Herein, we review the current state of nonconvulsive status epilepticus (NCSE). NCSE has recently been recognized as one of the causes of unexplained impaired consciousness in the neurosurgical or neurocritical setting. The causes of NCSE include not only central nervous system disorders such as craniotomy, stroke, traumatic brain injury, and central nervous system inflammation, but also severe critical conditions such as sepsis and uremia, among others. NCSE shows no overt clinical manifestations; therefore, prompt and correct diagnosis is difficult...
October 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27464471/medical-engineering-and-microneurosurgery-application-and-future
#17
Akio Morita, Shigeo Sora, Hirofumi Nakatomi, Kanako Harada, Naohiko Sugita, Nobuhito Saito, Mamoru Mitsuishi
Robotics and medical engineering can convert traditional surgery into digital and scientific procedures. Here, we describe our work to develop microsurgical robotic systems and apply engineering technology to assess microsurgical skills. With the collaboration of neurosurgeons and an engineering team, we have developed two types of microsurgical robotic systems. The first, the deep surgical systems, enable delicate surgical procedures such as vessel suturing in a deep and narrow space. The second type allows for super-fine surgical procedures such as anastomosing artificial vessels of 0...
October 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27464470/hearing-restoration-with-auditory-brainstem-implant
#18
Hirofumi Nakatomi, Satoru Miyawaki, Taichi Kin, Nobuhito Saito
Auditory brainstem implant (ABI) technology attempts to restore hearing in deaf patients caused by bilateral cochlear nerve injury through the direct stimulation of the brainstem, but many aspects of the related mechanisms remain unknown. The unresolved issues can be grouped into three topics: which patients are the best candidates; which type of electrode should be used; and how to improve restored hearing. We evaluated our experience with 11 cases of ABI placement. We found that if at least seven of eleven electrodes of the MED-EL ABI are effectively placed in a patient with no deformation of the fourth ventricle, open set sentence recognition of approximately 20% and closed set word recognition of approximately 65% can be achieved only with the ABI...
October 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27396396/perioperative-management-center-perio-for-neurosurgical-patients
#19
Takao Yasuhara, Tomohito Hishikawa, Takashi Agari, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Masahiro Kameda, Aiko Shinko, Joji Ishida, Masafumi Hiramatsu, Motomu Kobayashi, Yoshikazu Matsuoka, Toshihiro Sasaki, Yoshihiko Soga, Reiko Yamanaka, Takako Ashiwa, Akemi Arioka, Yasuko Hashimoto, Ayasa Misaki, Yuriko Ishihara, Machiko Sato, Hiroshi Morimatsu, Isao Date
Perioperative management is critical for positive neurosurgical outcomes. In order to maintain safe and authentic perioperative management, a perioperative management center (PERIO) was introduced to patients of our Neurosurgery Department beginning in June 2014. PERIO involves a multidisciplinary team consisting of anesthesiologists, dentists/dental hygienists/technicians, nurses, physical therapists, pharmacists, and nutritionists. After neurosurgeons decide on the course of surgery, a preoperative evaluation consisting of blood sampling, electrocardiogram, chest X-ray, and lung function test was performed...
September 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27298262/innovation-in-neurosurgery-intellectual-property-strategy-and-academia-industrial-collaboration
#20
Yuichi Murayama
Neurosurgery has tremendous possibilities for development of innovative medical devices. However, most of the neurosurgical devices used in Japan are imported products. Promotion and development of domestic medical devices is highly encouraged and it is one of the pillars of Prime Minister Shinzo Abe's growth strategy of Japanese economy. Innovative "Made in Japan" medical devices can be developed by interdisciplinary collaboration between industries and academic institutions. Proper orientation of medical and engineering education, social and administrative awareness of the need of facilitating the medical devices creative process with corresponding regulatory changes, and appropriate medical and technological infrastructure establishment are needed for stimulating medical device innovation...
September 15, 2016: Neurologia Medico-chirurgica
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