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Nederlands Tijdschrift Voor Geneeskunde

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https://www.readbyqxmd.com/read/28421977/-a-woman-with-pink-urine-and-a-pink-skin
#1
J A Versteeg, G A M van der Nat
A 48-year-old woman with fire-related inhalation injury had pink urine and a pink skin. This was caused by hydroxocobalamin, which was used to treat cyanide poisoning.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421976/-measles-after-mmr-vaccination
#2
R van Grootveld, L M Klitsie, D C M van der Kaay, A C T M Vossen, A C Dijkmans
BACKGROUND: The Dutch national vaccination program provides vaccination for mumps, measles and rubella (MMR vaccine) for all children. After vaccination with live attenuated viruses, the virus replicates on a limited scale. Replication may lead to mild symptoms occurring 5-14 days after MMR-vaccination, including fever, conjunctivitis and rash. Symptoms are comparable to those of a wildtype measles infection. CASE DESCRIPTION: A 14-month-old boy was admitted to the hospital with an impressive rash 13 days after MMR-vaccination...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421975/-analysis-of-variation-in-the-surgical-treatment-of-distal-radius-fracture
#3
M M J Walenkamp, M A M Mulders, C A Selles, J C Goslings, G P Westert, N W L Schep
OBJECTIVE: The optimum treatment of patients with distal radius fracture has not been entirely clarified resulting in possible major variations between hospitals in the number of patients undergoing surgical treatment. The objective of this study was to examine the variation in surgical treatment rates of patients with distal radius fractures across Dutch hospitals. DESIGN: Retrospective study. METHOD: Aggregated data for all patients with a distal radius fracture were obtained for 2012 and 2013 on the basis of reimbursement codes...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421974/-epigastric-pain-caused-by-a-gastric-wall-abscess
#4
S J G Leeuwerke, Y K Sze
BACKGROUND: Gastric wall abscesses are rare, but mortality rates from this type of gastritis are high. A foreign body or mucosal damage is often the cause of the abscess. Most patients have nonspecific symptoms, including general malaise and abdominal pain, sometimes accompanied by fever and weight loss. CASE DESCRIPTION: After various tests a 45-year-old man with epigastric pain was shown to have a gastric wall abscess. After endoscopic drainage of the abscess, followed by intravenous antibiotics, he made a complete recovery...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421973/-bitten-by-an-exotic-venomous-snake
#5
M A Dijkman, I de Vries, M van Dam, D W de Lange
BACKGROUND: Patients who have been bitten by an exotic venomous snake are at risk of severe morbidity and a fatal outcome following an incorrect risk-assessment. Treatment with an antivenom can be necessary and can turn out to be lifesaving. In the Netherlands there are only a few cases of bites from exotic venomous snakes each year. CASE DESCRIPTION: A 28-year-old man presented at the emergency department (ED) after having been bitten by a monocled cobra (Naja kaouthia)...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421972/-a-tumour-mistaken-for-a-scar
#6
A C van den Brand, A Erceg
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare type of cutaneous soft tissue sarcoma. The tumour metastasises rarely, but the percentage of recurrences is high and the tumour can be locally very aggressive. CASE DESCRIPTION: A 50-year-old man was referred to our clinic for a long existing scar on his back, which had become painful in the last few weeks. In the hospital we decided to take a biopsy. Based on the histopathological investigation, the diagnosis DFSP was made...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421971/-posttraumatic-appendicitis
#7
S Klis, T L Trang, M F Lutke Holzik
BACKGROUND: Posttraumatic appendicitis is an appendicitis that develops as a consequence of abdominal trauma. Trauma is a relatively rare cause of appendicitis which is nowadays rarely mentioned in surgical textbooks. CASE DESCRIPTION: We describe the case of a 12-year-old girl who presented to the emergency department six days after abdominal trauma caused by a fall from an electrical bicycle, complaining of fever and abdominal pain. Her symptoms were caused by a perforated appendicitis...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28401824/-biosimilar-registered-despite-the-netherlands-opposing-vote-greater-uncertainty-about-authorised-drugs-in-the-netherlands
#8
A G Vulto
On 1 April 2016 the Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion on a new biological medicine, Flixabi®, a biosimilar to infliximab (Remicade®); however, in the appendix of the European Public Assessment Report (EPAR) it appeared that an important minority (14 of 33 votes) opposed this decision, among them the Netherlands representative. In an original article, the Dutch Medicines Board (CBG-MEB) explained the reason for this decision, but still allowed the drug on the market...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28401823/-socioeconomic-differences-and-smoking-clear-connections-with-implications-for-tobacco-policy
#9
A E Kunst
- Smoking is more common among people with a lower educational level, professional qualifications and income. This is a major contributor to inequalities in health and mortality.- Inequalities in smoking appear to have their origin in early adolescence. Later in life these inequalities increase due to differences in smoking cessation between higher and lower socioeconomic status groups.- The inequalities in smoking cessation have already been explained in great detail. The close association between smoking and a lower level of education during adolescence is much less clear...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28401822/herziene-richtlijn-%C3%A2-behandeling-van-tabaksverslaving-en-stoppen-met-roken-ondersteuning%C3%A2
#10
N H Chavannes, E Meijer, L Wind, R C van der Graaf, C Rietbergen, E A Croes
- The revised guideline 'Treatment of tobacco addiction and smoking cessation support' offers health professionals a framework to provide evidence-based care to patients who smoke, which should aid in reducing smoking prevalence and smoke-related morbidity and mortality.- Four topics of the guideline have been revised: behavioural interventions, pharmacotherapy, e-health interventions and e-cigarettes. For the other topics, the recommendations from the 2009 version remain unaltered.- It is important that health professionals offer a made-to-measure smoking cessation advice and apply a fit-for-purpose smoking cessation intervention...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28401821/-70-gene-signature-as-an-aid-to-treatment-decisions-in-early-stage-breast-cancer
#11
J J M van der Hoeven
OBJECTIVE: The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. We sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical-pathological criteria in selecting patients for adjuvant chemotherapy. METHODS: In this randomized, phase 3 study, we enrolled 6693 women with early-stage breast cancer and determined their genomic risk (using the 70-gene signature) and their clinical risk (using a modified version of Adjuvant! Online)...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28401820/-a-man-with-a-curved-deformity-of-the-hand
#12
E M van Soest, G J de Jong, L Korswagen
A 63-year-old male was seen at the rheumatology outpatient clinic because of a curved deformity of his left hand, with fixed flexion of the MCP joints and hyperextension of the PIP and DIP joints. This so-called striatal hand, a feature of Parkinson's disease, can easily be confused with rheumatoid arthritis or Dupuytren's contracture.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28401819/-a-plea-for-selective-use-of-the-mammaprint-test
#13
M de Boer, A C Voogd, V C G Tjan-Heijnen
Recently, the results of the MINDACT study were published in The New England Journal of Medicine. The authors conclude that the MammaPrint test can prevent the use of chemotherapy in about 50% of breast cancer patients with a high-risk clinical profile because of the presence of a genomic low risk MammaPrint. We believe that the decision to use chemotherapy should not be based solely on the outcome of the MammaPrint test, as is suggested by the authors, but also on clinical factors, such as tumour size, nodal status and grade...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28401818/-analysing-gait-in-the-gp-s-consulting-room
#14
T van Meulenbroek, I P J Huijnen, G H H Meys, G M Rommers
Gait disorders are often seen in the general practitioner (GP)'s consulting room. Orthopaedic or neurological problems may lead to abnormalities in gait. A careful analysis is important to advice or refer the patient for additional diagnostics or treatment. Basic gait analysis can be performed on any patient by applying a systematic stepwise observation. This is illustrated here by three case reports. This observation starts by looking at parameters such as walking speed, safety, efficiency etc. Analysis of biomechanical pattern such as step frequency, stride length and a detailed analysis of the different joint movements during the stance and swing phase can subsequently be performed...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28378703/-carotid-sinus-massage-is-not-a-benign-intervention
#15
R B A van den Brink, F J de Lange
Carotid sinus massage for diagnosis and termination of supraventricular tachycardia (SVT) is still a widely used vagal manoeuvre in the A&E department. However, itsefficacy is limited (termination of the SVT in approximately 20%) and carotid sinus massage may be complicated by (potentially devastating) neurologic complications in 0.2-1% of the patients. There are safer interventions without neurologic complications, such as the modified Valsalva manoeuvre (efficacy 43%) and intravenous administration of adenosine (efficacy 75%)...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28378702/-a-man-with-a-primary-diffuse-b-cell-lymphoma-of-the-bone
#16
V H M Wanrooij, K S G Jie
A 63-year-old man suffered from persistent pain in the left knee that did not respond to local injections with bupivacaine and triamcinolone acetonide. The first X-ray of the knee did not show any abnormalities, but eight months later a lytic lesion in the left tibia was seen on X-ray. A PET/CT scan and histopathologic analysis of a biopsy revealed a primary diffuse B-cell lymphoma of the bone.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28378701/-the-gobstopper-of-the-medical-job-market-education-of-physicians-and-specialists-from-a-historical-perspective
#17
I Wallenburg, R M Bertens
Unemployment among young physicians has been a difficult problem for years. In this contribution, we are looking at the difficult medical job market from a historical perspective. The article shows that education of medical doctors and medical specialists has been politicised for a very long time, that ever-changing parties and interests are playing a role and that both the nature and objective of the issue - admission policy, whether to educate more or fewer physicians - have been shifting over time. We argue that there are no clear solutions available but that we, while learning from the past, must continually look for solutions that fit the current situation...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28378700/-carbapenem-resistant-bacteria-transferred-to-the-netherlands-patients-colonised-during-hospitalisation-in-romania
#18
M Hoogewerf, A E Budding, A M E Spoelstra-de Man, J Vloemans, W Rozemeijer
Three patients were recently transferred to two Intensive Care Units (ICUs) in the Netherlands from two different ICUs in Bucharest, Romania. The patients appeared to be colonised with several, partly identical, carbapenemase-producing bacteria (CPB) after a short hospitalisation in Romania. In this article, we show that it is important to be aware of the possibility that patients are colonised with CPB after a short hospitalisation abroad. This has consequences for infection prevention measurements, but probably also for the discontinuation of selective bowel decontamination in the ICU...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28378699/-is-a-once-daily-dose-of-furosemide-effective-literature-study-into-rational-for-dosing-of-short-acting-diuretic
#19
M M C O van IJzendoorn, E C Boerma, G J Navis
- Furosemide is a widely used short-acting diuretic with a steep dose-response curve.- Furosemide is commonly prescribed once daily, but because of its short-acting nature it is questionable if a once-daily regiment is effective.- Different physiological and pathophysiological principles influence the effect and period of efficacy of furosemide.- Studies in both healthy subjects and different patient categories do demonstrate efficacy of furosemide once daily, but also that furosemide prescribed twice daily is more effective...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28378698/-a-woman-with-severe-abdominal-pain-and-endometriosis-in-the-past
#20
T C Schuurs, E M Vandewalle, C Dickhoff
A 44-year-old woman came to the emergency department with severe pain in the right upper abdomen. Her medical history mentioned a low anterior resection 8 years ago because of severe endometriosis. The CT scan showed a ruptured right hemidiaphragm with herniation of the small intestine.
2017: Nederlands Tijdschrift Voor Geneeskunde
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