journal
https://read.qxmd.com/read/38325836/protective-mechanisms-of-juncus-effusus-and-carbonized-juncus-effusus-against-d-galactosamine-induced-acute-liver-injury-in-mice
#1
JOURNAL ARTICLE
Xiangming Wang, Menghui Zhao, Chengguo Ju, Hui Gao, Wei Wang
This study investigated the hepatoprotective effects of Juncus effusus (J. effusus) and Carbonized J. effusus against liver injury caused by D-galactosamine (D-GalN) in mice. J. effusus and Carbonized J. effusus were administered by gavage once daily starting seven days before the D-GalN treatment. The results of the study indicated that J. effusus and Carbonized J. effusus suppressed the D-GalN-induced generation of serum alanine transaminase (ALT), aspartate aminotransferase (AST), hepatic malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) was observed...
February 7, 2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38281765/enhanced-physical-stability-of-l-ascorbic-acid-in-an-ionic-liquid
#2
JOURNAL ARTICLE
Takeshi Oshizaka, Issei Takeuchi, Katsuya Mukae, Kenji Mori, Kenji Sugibayashi
Ionic liquid (IL) technology was used to enhance the stability of L-ascorbic acid (AA). Pyridoxine was selected as the counter cation for anionic AA in IL. After AA was dissolved in water at 40°C, its ratio decreased to 3.2% after 7 days. In contrast, the IL formulation showed negligible degradation, with almost no loss of AA even after 28 days. These results suggest that the use of IL enhances the stability of AA.
January 26, 2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38123341/development-of-ethylcellulose-microparticles-for-taste-masking-of-fexofenadine
#3
JOURNAL ARTICLE
Yuri Ikeuchi-Takahashi, Machi Morii, Kurumi Yamazaki, Aoi Shimana, Ikki Shibazaki, Yasuko Obata
For taste masking of fexofenadine hydrochloride (FXD), ethylcellulose (EC) microparticles with FXD were developed. The amounts of EC, Tween 80, and polyvinyl alcohol (PVA) in the composition had little effect on initial drug release properties. Based on the results of the drug recovery and the drug release properties, FXD(EC200) was the optimal FXD microparticle formulation. From the results of Fourier transform infrared spectroscopy spectra and X-ray diffraction patterns of FXD(EC200), FXD amorphization in the microparticles and interaction between FXD and other components were suggested, and the formation of a solid dispersion of FXD was suggested...
December 21, 2023: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38494725/systematic-studies-of-functional-group-tolerance-and-chemoselectivity-in-carbene-mediated-intramolecular-cyclopropanation-and-intermolecular-c-h-functionalization
#4
JOURNAL ARTICLE
Haruki Kanda, Ayaka Okabe, Shingo Harada, Tetsuhiro Nemoto
Generating reliable data on functional group compatibility and chemoselectivity is essential for evaluating the practicality of chemical reactions and predicting retrosynthetic routes. In this context, we performed systematic studies using a functional group evaluation kit including 26 kinds of additives to assess the functional group tolerance of carbene-mediated reactions. Our findings revealed that some intermolecular heteroatom-hydrogen insertion reactions proceed faster than intramolecular cyclopropanation reactions...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38494724/effect-of-two-photon-excitation-to-8-azacoumarin-derivatives-as-photolabile-protecting-groups
#5
JOURNAL ARTICLE
Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Peter Bolah, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura
An improvement of the two-photon excitation was achieved using 8-azacoumarin-type caged compounds, which showed large values of the two-photon uncaging action cross-section (δu >0.1 Goeppert-Mayer (GM)). In particular, the 7-hydroxy-6-iodo-8-azacoumarin (8-aza-Ihc)-caged compound showed an excellent uncaging action cross-section value (δu  = 1.28 GM). Therefore, 8-azacoumarin-type photolabile protecting groups (PPGs) can be used as two-photon excitation sources.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38479891/evaluating-a-retro-inverso-type-inhibitor-of-htlv-1-protease-as-a-competitive-inhibitor
#6
JOURNAL ARTICLE
Chiyuki Awahara, Daiki Oku, Kazuya Kobayashi, Yasunao Hattori
The inhibition mode of a retro-inverso (RI) inhibitor containing a hydroxyethylamine dipeptide isostere against the human T-cell leukemia virus type-1 (HTLV-1) protease was examined. Enzymatic evaluation of the RI-modified inhibitor containing a D-allo-Ile residue revealed that HTLV-1 was competitively inhibited. IC50 values of the RI-modified inhibitor and pepstatin A, a standard inhibitor of aspartic proteases, were nearly equivalent.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38479857/dissolution-profiles-of-oral-disintegrating-tablet-with-taste-masking-granule-polymer-coating-in-biorelevant-bicarbonate-buffer
#7
JOURNAL ARTICLE
Masaki Higashino, Kiyohiko Sugano
The current study aimed to explore the impact of buffer species on the dissolution behavior of orally disintegrating tablets (ODT) containing a basic polymer and its influence on bioequivalence (BE) prediction. Fexofenadine hydrochloride ODT formulations were used as the model formulations, Allegra® as the reference formulation, and generic formulations A and B as the test formulations. Allegra® , generic A, and generic B are ODT formulations that contain aminoalkyl methacrylate copolymers E (Eudragit® E, EUD-E), a basic polymer commonly used to mask the bitter taste of drugs...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38479853/organocatalyzed-amine-free-o-phosphorylation-of-alcohols-with-4-methylpyridine-n-oxide
#8
JOURNAL ARTICLE
Keisuke Yoshida, Wataru Hirano, Ryuuki Ota, Shinji Kitagaki
Amine-free phosphorylation of various alcohols was developed with 4-methylpyridine N-oxide in the presence of 4 Å molecular sieves at room temperature. This mild method gave various phosphorylated products in high yield and could be applied to acid- or base-sensitive substrates. Furthermore, this method was also effective for the chemoselective phosphorylation of diols or polyols.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38462461/synthesis-of-a-cyclic-hexaamide-consisting-of-a-brominated-m-phenylene-repeating-unit
#9
JOURNAL ARTICLE
Akihiro Yokoyama, Ayaka Chino, Kenta Rakumitsu
Aiming to synthesize a cyclic hexaamide, 4-bromo-3-(isobutylamino)benzoic acid was subjected to self-condensation reactions in the presence of either dichlorotriphenylphosphorane in 1,1,2,2-tetrachloroethane or tetrachlorosilane in pyridine. However, instead of the targeted cyclic hexaamide, the cyclic triamide and the cyclic tetraamide were obtained. The cyclic hexaamide was successfully synthesized via the self-condensation of the dimer, which was synthesized in five steps from 4-bromo-3-(isobutylamino)benzoic acid...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38447973/effect-of-concomitant-drugs-on-sodium-zirconium-cyclosilicate-hydrate-in-artificial-intestinal-juice
#10
JOURNAL ARTICLE
Yuri Mizuno, Fumihiko Ogata, Yugo Uematsu, Naohito Kawasaki
To explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial intestinal juice. Initially, we assessed the potassium ion adsorption capacity, ranking it as follows: calcium polystyrene sulfonate (CPS, 54.9 mg/g) < sodium polystyrene sulfonate (SPS, 62...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432952/errata-for-chemical-and-pharmaceutical-bulletin
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432909/development-of-a-potential-modulated-electrochemiluminescence-measurement-system-for-selective-and-sensitive-determination-of-the-controlled-drug-codeine
#12
JOURNAL ARTICLE
Fumiki Takahashi, Yuki Shimosaka, Shuki Mori, Mayu Kaneko, Yuta Harayama, Kanya Kobayashi, Taku Shoji, Yasuo Seto, Hirosuke Tatsumi, Jiye Jin
Codeine is a common analgesic drug that is a pro-drug of morphine. It also has a high risk of abuse as a recreational drug because of its extensive distribution as an OTC drug. Therefore, sensitive and selective screening methods for codeine are crucial in forensic analytical chemistry. To date, a commercial analytical kit has not been developed for dedicated codeine determination, and there is a need for an analytical method to quantify codeine in the field. In the present work, potential modulation was combined with electrochemiluminescence (ECL) for sensitive determination of codeine...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432908/electrochemical-analysis-for-total-alkalinity-of-water-by-the-measurement-of-cathodic-prepeak-of-quinone-caused-by-surplus-acid
#13
JOURNAL ARTICLE
Akira Kotani, Miyu Sakazume, Koichi Machida, Kazuhiro Yamamoto, Hideki Hakamata
In this study, an electrochemical analysis, coupled with the concept of back neutralization titration and the voltammetric determination of surplus acid, is proposed for determining the total alkalinity of water samples. When linear sweep voltammetry of 3,5-di-tert-butyl-1,2-benzoquinone (DBBQ) with H2 SO4 in a water and ethanol (44 : 56, v/v) mixture was carried out using a bare glassy carbon working electrode, a cathodic prepeak of DBBQ caused by H2 SO4 was observed on the voltammogram at a more positive potential than when compared with the original cathodic peak of DBBQ...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432907/construction-of-biosensing-system-for-glycated-albumin-using-an-electron-transfer-peptide-modified-protein-probe
#14
JOURNAL ARTICLE
Michiru Ito, Kazuharu Sugawara
Glycated albumin (GA) is one of the proteins that replaces several sugar moieties and can be used as an indicator of diabetes mellitus. We developed a sensing system that uses GA in the early detection of diabetes mellitus. In this study, H6 Y4 C acetylated (Ac-) at the N-terminals of the peptide was combined with wheat germ agglutinin (WGA) to recognize glucose moieties. The Ac-H6 Y4 C-WGA was constructed as a GA-sensing probe. The tyrosine residues of Y4 C exhibited an oxidation peak, and His-tag moieties were introduced to separate Ac-H6 Y4 C-WGA in the synthesis of the probe...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432906/evaluation-of-antibiotic-penicillin-g-activities-based-on-electrochemical-measurement-of-a-tetrazolium-salt
#15
JOURNAL ARTICLE
Hikaru Ikeda, Akira Tokonami, Shigeki Nishii, Masashi Fujita, Yojiro Yamamoto, Yasuhiro Sadanaga, Hiroshi Shiigi
This study focused on the electrochemical properties of tetrazolium salts to develop a simple method for evaluating viable bacterial counts, which are indicators of drug susceptibility. Considering that the oxidized form of tetrazolium, which has excellent cell membrane permeability, changes to the insoluble reduced form formazan inside the cell, the number of viable cells was estimated based on the reduction current of the tetrazolium remaining in the bacterial suspension. Dissolved oxygen is an important component of bacterial activity...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432905/electrochemical-characterization-of-a-novel-organoelectrocatalyst-7-azabicyclo-2-2-1-heptan-7-ol-abhol-and-its-application-to-electrochemical-sensors
#16
JOURNAL ARTICLE
Masaki Toda, Kyoko Sugiyama, Fumiya Sato, Yusuke Sasano, Tsutomu Fujimura, Yoshiharu Iwabuchi, Katsuhiko Sato
Electrochemical enzyme sensors are suitable for simple monitoring methods, for example, as glucose sensors for diabetic patients; however, they have several disadvantages arising from the properties of the enzyme. Therefore, non-enzymatic electrochemical sensors using functional molecules are being developed. In this paper, we report the electrochemical characterization of a new hydroxylamine compound, 7-azabicyclo[2.2.1]heptan-7-ol (ABHOL), and its application to glucose sensing. Although the cyclic voltammogram for the first cycle was unstable, it was reproducible after the second cycle, enabling electrochemical analysis of ethanol and glucose...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432904/foreword
#17
JOURNAL ARTICLE
Akira Kotani
No abstract text is available yet for this article.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38432903/unusual-enzymatic-c-c-bond-formation-and-cleavage-reactions-during-natural-product-biosynthesis
#18
JOURNAL ARTICLE
Richiro Ushimaru
Natural products from plants and microorganisms provide a valuable reservoir of pharmaceutical compounds. C-C bond formation and cleavage are crucial events during natural product biosynthesis, playing pivotal roles in generating diverse and intricate chemical structures that are essential for biological functions. This review summarizes our recent findings regarding biosynthetic enzymes that catalyze unconventional C-C bond formation and cleavage reactions during natural product biosynthesis.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38417869/8-iodoisoquinolinone-a-conformationally-rigid-highly-reactive-2-iodobenzamide-catalyst-for-the-oxidation-of-alcohols-by-hypervalent-iodine
#19
JOURNAL ARTICLE
Takayuki Yakura, Tomoya Fujiwara, Kanna Asakubo, Hema Naga Lakshmi Perumalla, Mitsuha Uzu, Takashi Okitsu, Kengo Kasama, Hisanori Nambu
The first lactam-type 2-iodobenzamide catalysts, 8-iodoisoquinolinones 8 (IB-lactam) and 9 (MeO-IB-lactam), were developed. These catalysts have a conformationally rigid 6/6 bicyclic lactam structure and are more reactive than the previously reported catalysts 2-iodobenzamides 4 (IBamide) and 5 (MeO-IBamide) for the oxidation of alcohols. The lactam structure could form an efficient intramolecular I---O interaction, depending on the size of the lactam ring.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38417868/development-of-a-water-soluble-self-assembling-analogue-of-vizantin
#20
JOURNAL ARTICLE
Mayo Nakano, Kyohei Sakamoto, Naoto Yamasaki, Yui Asano, Masataka Oda, Hironobu Takahashi, Takashige Kawakami, Masahisa Inoue, Hirofumi Yamamoto
Vizantin, 6,6'-bis-O-(3-nonyldodecanoyl)-α,α'-trehalose, has been developed as a safe immunostimulator on the basis of a structure-activity relationship study with trehalose 6,6'-dicorynomycolate. Our recent study indicated that vizantin acts as an effective Toll-like receptor-4 (TLR4) partial agonist to reduce the lethality of an immune shock caused by lipopolysaccharide (LPS). However, because vizantin has low solubility in water, the aqueous solution used in in vivo assay systems settles out in tens of minutes...
2024: Chemical & Pharmaceutical Bulletin
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