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Chemical & Pharmaceutical Bulletin

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https://www.readbyqxmd.com/read/28320975/cytotoxic-steroids-from-the-vietnamese-soft-coral-sinularia-leptoclados
#1
Ninh Thi Ngoc, Tran Thi Hong Hanh, Nguyen Van Thanh, Do Thi Thao, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh
Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC50 = 21.13±0.70 µM) and colon adenocarcinoma (SW480, IC50 = 28.65±1.53 µM) cell lines were observed for 1 and against acute leukemia (HL-60, IC50 = 20...
March 18, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28320974/dissipation-of-flonicamid-in-honeysuckle-and-its-transfer-during-brewing-process
#2
Yujie Wang, Jian Xue, Hongyu Jin, Shuangcheng Ma
The dissipation of flonicamid in Honeysuckle and transfer pattern from Honeysuckle to its tea infusion were investigated. Flonicamid was applied on Honeysuckle crop at two dosages, 60 g of active gradient per hectare (g a.i. hm(-2)) and 180 g a.i. hm(-2) (recommended and triple the recommended) in Fenqiu, Henan Province in 2015 and 2016. Gas chromatography-Electron Capture Detector (GC-ECD) detection methods were developed for the analysis of flonicamid residues in honeysuckles and its infusion. The recoveries in both honeysuckles and its infusion ranged from 81...
March 18, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28320998/design-synthesis-and-biological-evaluation-of-potent-human-glyoxalase-i-inhibitors
#3
Tian Jin, Jing Zhai, Xiao Liu, Yan Yue, Maolin Huang, Zonghe Li, Caixia Ni, Qishan Deng, Yankui Sang, Zhongwei Yao, Hong Zhang, Xiaopeng Hu, Zhe-Bin Zheng
Several glutathione derivatives bearing the S-(N-aryl-N-hydroxycarbamoyl) or S-(C-aryl-N-hydroxycarbamoyl) moieties [10, 10' and 13-15] were synthesized, characterized, and their human glyoxalase I (hGLO1) inhibitory activity was evaluated. Compound 10 was proved to be the effective hGLO1 inhibitor with a Ki value of 1 nM and the inhibition effect of compound 10 on hGLO1 was nearly ten-fold higher than that of the strongest inhibitor 2 (Ki = 10 nM) which has been reported in the field of glutathione-type hGLO1 inhibitors...
March 17, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28163272/a-study-of-the-strength-of-a-template-molecule-a-functional-monomer-interaction-that-affects-the-performance-of-molecularly-imprinted-polymers-and-its-application-to-chiral-amplification
#4
Takuro Yasuyama, Hirofumi Matsunaga, Shin Ando, Tadao Ishizuka
A novel type of molecularly imprinted polymer (MIP), N-benzoyl-(S)-valine anilide-imprinted polymer (IP-2), was prepared using hydrogen-bonding interactions as a main force in the pre-polymerization step. The performance of the IP-2 was evaluated via batch procedure and compared with a (S)-valine anilide-imprinted polymer (IP-1) that was prepared using an ionic interaction that is stronger than hydrogen bonding. Although both polymers showed a preferential adsorbability for (S)-amino acid derivatives, different performances were observed in terms of adsorbability and enantioselectivity...
February 4, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28132960/selective-targeting-of-cancer-stem-cells-by-2-aminodihydroquinoline-analogs
#5
Heejoo Park, Yeongji Yu, Hyejin Kim, Eun Lee, Hani Lee, Raok Jeon, Woo-Young Kim
Many aminodihydroquinoline compounds have been studied to determine their cytotoxicity to cancer cells. However, anti- cancer stem cells (CSCs) activity of aminodihydroquinoline has not been tested in spite that CSC is believed to do an important roles in chemotherapy resistance and recurrence. The CSC selective targeting activities of 10 recently synthesized 2-aminodihydroquinoline analogs were examined on CSCs and bulk culture of a glioblastoma cell line. A diethylaminopropyl substituted aminodihydroquinoline, 5h, showed a strong anti-CSC effect and general cytotoxicity...
January 27, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28090067/discovery-and-synthesis-of-amino-acids-modified-deoxycholic-acid-derivatives-and-in-vitro-antiproliferative-evaluation
#6
Chunhui Zhao, Peizhe Zhao, Bin Feng, Xiyan Hou, Longxuan Zhao
A series of deoxycholic acid (DCA) derivatives bearing amino acid moiety has been synthesized and investigated for their potential antiproliferative activities. DCA derivative compounds were synthesized by a two or three step synthetic approach. Their bioactivities were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and Western blotting analysis on three tumor cell lines A549 (human lung cancer cell line), MCF-7 (human breast cancer cell line) and HeLa (human cervical carcinoma cell)...
March 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28077809/cytotoxic-steroids-from-the-vietnamese-soft-coral-sinularia-conferta
#7
Ninh Thi Ngoc, Pham Thi Mai Huong, Nguyen Van Thanh, Nguyen Thi Phuong Chi, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh
Twelve steroids, including five new compounds 1-5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against three human cancer cell lines, lung carcinoma (A-549), cervical adenocarcinoma (HeLa), and pancreatic epithelioid carcinoma (PANC-1), were evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays. Among isolated compounds, 10 exhibited potent cytotoxic effects on all three tested cell lines with IC50 values of 3...
March 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27980251/preparation-and-characterization-of-hydroxypropyl-methylcellulose-polycarbophil-mucoadhesive-blend-films-using-a-mixture-design-approach
#8
Pakorn Kraisit, Sontaya Limmatvapirat, Jurairat Nunthanid, Pornsak Sriamornsak, Manee Luangtana-Anan
The objectives of this study were to prepare the hydroxypropyl methylcellulose (HPMC)/polycarbophil (PC) mucoadhesive blend film and to investigate the main and interaction effect of HPMC and PC mixtures on the physicochemical and mechanical properties of blend films using a simplex lattice mixture design approach. The cubic and quadratic models were selected to analyze mucoadhesive properties in terms of work of adhesion and maximum detachment force, respectively. It was shown that HPMC/PC blend film had higher mucoadhesive properties than pure HPMC film...
March 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27928130/application-of-terahertz-attenuated-total-reflection-spectroscopy-to-detect-changes-in-the-physical-properties-of-lactose-during-the-lubrication-process-required-for-drug-formulation
#9
Masafumi Dohi, Wataru Momose, Kazunari Yamashita, Tadashi Hakomori, Shusaku Sato, Shuji Noguchi, Katsuhide Terada
Manufacturing the solid dosage form of an orally administered drug requires lubrication to enhance manufacturability, ensuring that critical quality attributes such as disintegration and dissolution of the drug product are maintained during manufacture. Here, to evaluate lubrication performance during manufacture, we used terahertz attenuated total reflection (THz-ATR) spectroscopy to detect differences in the physical characteristics of the lubricated powder. We applied a simple formulation prepared by blending granulated lactose as filler with magnesium stearate as lubricant...
February 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27916782/cytotoxic-homoisoflavonoids-from-ophiopogon-japonicus-tubers
#10
Nguyen Hai Dang, Nguyen Dinh Chung, Ha Manh Tuan, Nguyen Tuan Hiep, Nguyen Tien Dat
A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B-D (2-4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 cancer cells with IC50 values ranging from 0.51 to 0...
February 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27904030/formulation-optimization-and-in-vitro-characterization-of-orally-disintegrating-films-using-a-factorial-design-and-mathematical-modeling-for-drug-release
#11
Yeongbin Lee, Prakash Thapa, Seong Hoon Jeong, Mi Hee Woo, Du Hyung Choi
Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as a film-forming polymer. A factorial design was utilized for optimization with three control factors: ethanol ratio, plasticizer ratio, and the type of plasticizer. Tensile strength, disintegration time, water contact angle, and thickness were chosen as responses...
February 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27904016/the-measurement-of-meloxicam-and-meloxicam-metabolites-in-rat-plasma-using-a-high-performance-liquid-chromatography-ultraviolet-spectrophotometry-method
#12
Aoi Miyamoto, Takahiko Aoyama, Yoshiaki Matsumoto
A high-performance liquid chromatography-ultraviolet spectrophotometry (HPLC-UV) method for the determination of meloxicam (MEL) and meloxicam metabolites (5'-hydroxy meloxicam (5-HMEL) and 5'-carboxy meloxicam (5-CMEL)) has been developed. After extraction of MEL, 5-HMEL, and 5-CMEL from rat plasma using Oasis HLB cartridges, the extracts were separated with a Luna C18 (2) 100 A column (5 µm, 4.6×150 mm, Phenomenex) using a mobile phase of 50 mM phosphate buffer (pH 2.15, solvent A) and acetonitrile (solvent B) at a flow rate of 0...
February 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27890876/synthesis-and-antifungal-in-vitro-evaluation-of-pyrazolo-3-4-b-pyridines-derivatives-obtained-by-aza-diels-alder-reaction-and-microwave-irradiation
#13
Jairo Quiroga, Yazmín Villarreal, Jaime Gálvez, Alejandro Ortíz, Braulio Insuasty, Rodrigo Abonia, Marcela Raimondi, Susana Zacchino
A series of pyrazolo[3,4-b]pyridines were prepared by a microwave-assisted aza-Diels-Alder reaction between pyrazolylformimidamides 1 and β-nitrostyrenes 2 in toluene as the solvent. This procedure provides a simple one-step and environmentally friendly methodology with good yields for the synthesis of these compounds. All compounds were tested for antifungal activity against two clinically important fungi Candida albicans and Cryptococcus neoformans. Within the compounds of the series bearing a -CH3 group on the carbon C-3 of the azole ring (3a-e), the compound without a substituent on the p'-phenyl ring (3a), showed the best activity against both fungi, followed by the p'-Br-phenyl (3c)...
February 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250351/kinetic-study-of-the-equilibration-between-carminic-acid-and-its-two-isomers-isolated-from-cochineal-dye
#14
Kazumasa Zaima, Azusa Fukamachi, Ryoko Yagi, Yusai Ito, Naoki Sugimoto, Hiroshi Akiyama, Kazufusa Shinomiya, Naoki Harikai
Carminic acid (CA) is a major component of cochineal dye used in food additives, cosmetics, and pharmaceuticals. CA and its isomers, 2-C-α-glucofuranoside and 2-C-β-glucofuranoside of kermesic acid (DCIV and DCVII, respectively), were isolated from cochineal dye and the equilibrium constants (K) between CA, DCIV and DCVII were investigated. DCIV was partially converted to CA and DCVII, and DCVII was converted to CA and DCIV, whereas CA was very stable and only very slightly converted to DCIV and DCVII. Most of the DCIV and DCVII was converted to CA under aqueous conditions...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250350/aglaiabbrevins-a-d-new-prenylated-bibenzyls-from-the-leaves-of-aglaia-abbreviata-with-potent-ptp1b-inhibitory-activity
#15
Pan Sun, Chang-Sheng Jiang, Yi Zhang, Ai-Hong Liu, Tong-Jun Liang, Jia Li, Yue-Wei Guo, Jian-Mei Jiang, Shui-Chun Mao, Bin Wang
Four new prenylated bibenzyls, named aglaiabbrevins A-D (2, 4-6), were isolated from the leaves of Aglaia abbreviata, along with two known related analogues, 3,5-dihydroxy-2-[3,7-dimethyl-2(E),6-octadienyl]bibenzyl (7) and 3,5-dihydroxy-2-(3-methyl-2-butenyl)bibenzyl (8). The structures of the new compounds were elucidated on the basis of extensive spectroscopic experiments, mainly one and two dimensional (1D- and 2D)-NMR, and the absolute configuration of 5 was determined by the measurement of specific rotation...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250349/adsorption-capability-of-cationic-dyes-methylene-blue-and-crystal-violet-onto-poly-%C3%AE-glutamic-acid
#16
Fumihiko Ogata, Noriaki Nagai, Naohito Kawasaki
In this study, the adsorption capability of cationic dyes, which were methylene blue and crystal violet, by poly-γ-glutamic acid (PGA) in a single or binary solution system was investigated. The effect of the molecular weight of PGA, initial dye concentration, solution pH, and temperature on the adsorption of dyes was evaluated. The adsorption mechanism of dyes onto PGA was the interaction between -COOH group on the PGA surface and the polarity groups of dyes. These results indicated that PGA is useful for removal of dyes and cationic organic compounds from a single or binary solution system...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250348/complexes-of-myo-inositol-hexakisphosphate-ip6-with-zinc-or-lanthanum-for-the-decorporation-of-radiocesium
#17
Kazuma Ogawa, Miho Aoki, Tadahisa Fukuda, Sumi Kadono, Tatsuto Kiwada, Akira Odani
Radioactive nuclides leak into the surrounding environment after nuclear power plant disasters, such as the Chernobyl accident and the Fukushima Daiichi Nuclear Power Plant disaster. Cesium-137 ((137)Cs) (t1/2=30.1 year), a water-soluble radionuclide with a long physical half-life, contaminates aquatic ecosystems and food products. In humans, (137)Cs concentrates in muscle tissue and has a long biological half-life, indicating it may be harmful. myo-Inositol-hexakisphosphate (IP6) is a compound found in grain, beans, and oil seeds...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250347/synthesis-biological-evaluation-and-molecular-docking-of-avicequinone-c-analogues-as-potential-steroid-5%C3%AE-reductase-inhibitors
#18
Wiranpat Karnsomwan, Ponsawan Netcharoensirisuk, Thanyada Rungrotmongkol, Wanchai De-Eknamkul, Supakarn Chamni
Avicequinone C (5a), a furanonaphthoquinone isolated from the Thai mangrove Avicennia marina has been shown previously to have interesting steroid 5α-reductase type 1 inhibitory activity. In this study, a series of avicequinone C analogues containing furanonaphthoquinone with different degrees of saturation and substituents at the furan ring were synthesized. The resulting synthetic avicequinone C and analogues (5a-f) along with some related compounds including 2,5-dihydroxy-1,4-benzoquinone (6) and natural naphthoquinones such as lawsone (7a) and lapachol (7b) were evaluated for their in vitro cell viability and steroid 5α-reductase type 1 inhibitory activities using the cultured cell line of human keratinocytes (HaCaT)...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250346/an-efficient-strategy-for-the-synthesis-of-1-trifluoromethylsulfonamido-propan-2-yl-esters-and-the-evaluation-of-their-cytotoxic-activity
#19
Omar Gómez-García, Elizabeth Gómez, César Monzón-González, Teresa Ramírez-Apan, Cecilio Álvarez-Toledano
An efficient method for the synthesis of 1-(trifluoromethylsulfonamido)propan-2-yl benzoates is described, the products of the reaction were characterized by heteronuclear single quantum coherence spectroscopy (HSQC), heteronuclear multiple bond correlation (HMBC) and NMR experiments. The overall process began with the activation of the oxazoline ring by triflic anhydride, followed by the opening of the five-membered ring in the 5-methyl-2-phenyl-4,5-dihydrooxazole system. The cytotoxic activity of the new trifluoromethyl sulfonamides was evaluated with six cancer cell lines and human gingival fibroblasts, posteriorly analyzing the influence on cytotoxicity exerted by the withdrawing and donor substituents at the para-position of the phenyl ring...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250345/design-and-synthesis-of-pyridazine-containing-compounds-with-promising-anticancer-activity
#20
Salwa Elmeligie, Eman Mohamed Ahmed, Suzan Mohamed Abuel-Maaty, Sawsan Abo-Bakr Zaitone, Demiana Samir Mikhail
Certain pyridazine containing compounds 2a-f, 3a, b, 4a, b, 5a, b, 6a and b were synthesized and characterized by spectroscopic means and elemental analysis. All the synthesized compounds were screened for their cytotoxic activity in vitro on colon cancer cell line (HCT-116) and breast cancer cell line (MCF-7). In addition, the antitumor activity of the synthesized compounds was tested in vivo against Ehrlich's ascites carcinoma (EAC) solid tumor grown in mice. The in vitro vascular endothelial growth factor receptor (VEGFR) enzyme inhibition assay was carried out for the most active compounds at a single dose of 10 µM...
2017: Chemical & Pharmaceutical Bulletin
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