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Neoplasma

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https://www.readbyqxmd.com/read/28052685/occurrence-of-malignancies-after-kidney-transplantation-in-adults-slovak-multicenter-experience
#1
Z Zilinska, M Sersenova, M Chrastina, J Breza Sr, L Bena, T Baltesova, A Jurcina, R Roland, E Lackova, M Cellar, L Laca, I Dedinska
Malignancies are one of the three major causes of renal recipient´s death with a functioning graft after cardiovascular diseases and infections. Among the variety of risk factors, including conventional and specific to transplant recipients, the duration of immunosuppressive therapy, the intensity of therapy, and the type of immunosuppressive agent all have an impact on development of post-transplant malignancy. The aim of our retrospective study was to document the incidence, the type of malignancies, the patient/graft survival in the group of kidney transplant recipients in Slovak Republic, and to identify the factors which influenced the outcome...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28052684/discordance-between-clinical-and-pathological-tnm-classification-influence-on-results-of-treatment-and-prognosis-in-patients-with-laryngeal-cancer
#2
P Celakovsky, D Kalfert, K Smatanova, P Kordac, J Laco, V Chrobok
The goals of this retrospective cohort study were to compare the results of clinical and pathological TNM staging in patients with laryngeal squamous cell carcinoma and to determine the impact of the discordance on prognosis and treatment results. A total of 124 patients with laryngeal cancer, primarily indicated for surgical treatment, were enrolled. The concordance or discordance between the clinical and pathological staging was compared with the frequency of cancer relapse and disease-specific survival. Other potential prognostic factors, like age, the stage and location of the primary tumor, the status of neck lymph nodes, histological margins, and an indication for postoperative radiotherapy, were also evaluated...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28052683/cytotoxic-t-lymphocyte-associated-antigen-4-rs231775-polymorphism-and-osteosarcoma-an-updated-systematic-review-and-meta-analysis
#3
N Bilbao-Aldaiturriaga, A PatiNo-Garcia, I Martin-Guerrero, A Garcia-Orad
Systematic reviews on osteosarcoma have concluded that CTLA4 rs231775 AA genotype influences risk for the disease in the Chinese population. Remarkably, rs231775 shows different frequencies in different human populations. Therefore, it would be interesting to know whether this SNP is related to the risk of osteosarcoma in other populations. The present study aimed to evaluate the association between rs231775 and the susceptibility of osteosarcoma in the Spanish population. We performed an updated meta-analysis including a total of 538 cases and 623 controls...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28052682/prognostic-significance-of-mapk-topo-ii%C3%AE-and-e-cadherin-immunoexpression-in-ovarian-serous-carcinomas
#4
D Sundov, B Petric Mise, I Mrklic, B Bacic, E Vrdoljak, S Tomis
Ovarian cancer accounts for only 3% of all cancers in women but is the most lethal gynaecologic malignancy. Low-grade and high-grade ovarian serous carcinomas (OSCs) represent two different diseases with different prognosis, approaches to detection and treatment. We assessed correlation between, MAPK, topoIIα, E-cadherin immunoexpression and clinicopathological features with overall survival (OS) in OSCs. The study included 81 patients undergoing surgery between January 1995 and December 2005.Formalin fixed paraffin embedded tumour sections were reviewed and examined immunohistochemically using antibodies against MAPK, topoIIα and E-cadherin...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28052681/prognostic-impact-of-lat1-and-cd98-expression-in-cutaneous-angiosarcoma
#5
A Shimizu, K Kaira, Y Okubo, D Utsumi, M Yasuda, H Tominaga, N Oriuchi, Y Kanai, K Takahashi, O Ishikawa
L-type amino acid transporter 1 (LAT1) and CD98 are frequently expressed in various human cancers, and closely correlated with tumor aggressiveness and survival. However, little is known about the expression of LAT1 and CD98 in cutaneous angiosarcoma. The aim of this study is to investigate the clinicopathological significance of these markers in the dismal disease. A total of 52 patients with cutaneous angiosarcoma were retrospectively reviewed. Immunohistochemical staining of tumor specimens were evaluated using anti-LAT1, CD98 and Ki-67 antibodies...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043156/absence-of-braf-mutation-in-pheochromocytoma-and-paraganglioma
#6
T Vosecka, A Vicha, T Zelinka, P Jencova, K Pacak, J Duskova, J Benes, A Guha, L Stanek, M Kohoutova, Z Musil
Pheochromocytomas and Paragangliomas (PHEO/PARA) are rare endocrine tumors originating from the adrenal medulla. More than 20 genes are involved in the tumorigenesis of these tumors, but a substantial part of the causative genetic events remains unexplained. A recent study has reported the presence of the activating BRAF V600E mutation in PCC, suggesting a role for BRAF activation in tumor development. Other studies have not find this mutation. This study investigates the occurrence of the BRAF V600E mutation in these tumors...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043155/new-concept-of-the-axin2-rs2240308-polymorphism-and-cancer-risk-an-updated-meta-analysis
#7
Y Yu, Y Tao, L Liu, J Yang, L Wang, X Li, X Zhuang, M Chu
Previous meta-analyses reported that the variant T allele of Axin2 rs2240308 is associated with a decreased cancer risk. However, more recent findings have been inconsistent. Therefore, we carried out an updated meta-analysis to examine whether this polymorphism is still associated with a decreased cancer risk. Twelve articles, including 14 case-control studies (2,215 cases and 2,481 controls), were included in our study. Surprisingly, different from previous meta-analyses, no significant association between Axin2 rs2240308 polymorphism and cancer risk was observed (dominant model: OR=0...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043154/prognostic-value-of-apoptosis-inducing-factor-in-uveal-melanoma
#8
V Krasnik, A Furdova, Z Svetlosakova, D Kobzova, H Gergisakova, L Feketeova, M Svetlosak, A Barta, P Babal
In malignant tumors including uveal melanoma there is a continuous effort in search for additional and relevant factors with predictive value and possible therapeutic indications. In the present work we evaluated the 5-year mortality in a group of patients with surgically treated uveal melanoma and its relation to selected demographic, clinical and histopathological parameters, including the expression of apoptosis inducing factor (AIF) in the neoplastic tissue.We analyzed retrospectively the clinical data of patients with uveal melanoma treated surgically (enucleation, endoresection, exenteration) in the period from 2001 to 2007 (n=54)...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043153/outcome-of-egfr-inhibitors-treatment-in-advanced-nsclc-patients-not-enrolled-in-clinical-trials
#9
M Mencoboni, R A Filiberti, P Taveggia, A Bruzzone, A Garuti, L Del Corso, E Ginocchio, A Brianti, C Simonassi, P Zucali
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become a treatment after first-line chemotherapy in patients with advanced NSCLC. We assessed the predictive and prognostic role of EGFR and Kras mutations in NSCLC patients treated with TKIs after progression, not included in clinical trials. Gefitinib 250 mg or Erlotinib 150 mg per os were administered to 70 patients. Radiological assessment was performed every six weeks. EGFR and Kras mutations were found in 21.4% and 24.3% of patients, respectively...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043152/mir-383-inhibits-ovarian-cancer-cell-proliferation-invasion-and-aerobic-glycolysis-by-targeting-ldha
#10
R L Han, F P Wang, P A Zhang, X Y Zhou, Y Li
MicroRNAs (miRNAs) are differentially expressed in various cancers and act as oncogenes or tumor suppressors. MiR-383 has been characterized as a cancer suppressor in several cancers. However, the exact expression patterns of miR-383 and the precise molecular mechanisms underlying its role in ovarian cancer have not been investigated thoroughly. In this study, we found that the expression of miR-383 was significantly downregulated in ovarian cancer tissues and ovarian cancer cell lines. Ectopic expression of miR-383 remarkably suppressed the ovarian cancer cell proliferation by enhancing cell apoptosis and significantly inhibited the invasion of ovarian cancer cells, while low expression of miR-383 exhibited the opposite effect...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043151/identification-of-magea12-as-a-prognostic-outlier-gene-in-gastric-cancers
#11
J Wu, J Wang, W Shen
Melanoma antigen (MAGE) family genes are frequently over-expressed in a subset population of multiple cancers, and serve as idea therapeutic targets; however, their distribution pattern in gastric cancers has not yet been evaluated. In this study, we first performed a cancer outlier profile analysis (COPA) on a series of public gene expression datasets of gastric cancer, and identified MAGEA12 showing a significant outlier expression model reproducibly. We further in silico validated that MAGEA12 outlier over-expression were associated with poor clinical outcome using six microarray datasets from GEO database...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043150/histone-deacetylase-inhibitors-in-plasma-cell-leukemia-treatment-effect-of-bone-marrow-microenvironment
#12
I Burianova, K Kuzelova, O Mitrovsky, I Spicka, P StOckbauer, M Zackova
In the presented study we analysed the effect of histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) on human plasma cell leukemia (PCL) cell line UHKT-944 in the presence of bone marrow microenvironment (BMM). For the analysis, the cells were cultured alone, with bone marrow stromal cells (BMSCs), with extracellular matrix (ECM) components or with interleukin-6, and treated with varied concentrations of SAHA and VPA for 24/48 hours. To study the effect of HDACi, we investigated cell proliferation, apoptosis, cell cycle and changes in selected signalling pathways...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043149/mesenchymal-stromal-cells-producing-tnf%C3%AE-lack-inhibitory-effect-against-a375-experimental-lung-metastasis
#13
S Tyciakova, M Matuskova, R Bohovic, L Kucerova
Cell-based anticancer therapy using mesenchymal stromal cells (MSCs) engineered to express therapeutic genes has a potential to target the cancer cells in vivo. Metastatic dissemination of melanoma remains a serious problem in the treatment. In our previous work we used MSCs overexpressing gene for tumor necrosis factor α (TNFα; MSCs/TNFα), and we achieved inhibition of melanoma xenograft growth when engineered MCSs/TNFα were coinjected with tumor cells subcutaneously. The TNFα as a pleiotropic cytokine induces apoptosis of tumor cells, creates "tumor resistant" microenvironment, enhances immune response and can have tumor destructive capacity in selected tumor types, especially in tumors of mesodermal origin...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043148/analysis-of-differentially-co-expressed-genes-based-on-microarray-data-of-hepatocellular-carcinoma
#14
Y Wang, T Jiang, Z Li, L Lu, R Zhang, D Zhang, X Wang, J Tan
Hepatocellular carcinoma (HCC) is the third leading cause of cancer related death worldwide. Although great progress in diagnosis and management of HCC have been made, the exact molecular mechanisms remain poorly understood. The study aims to identify potential biomarkers for HCC progression, mainly at transcription level. In this study, chip data GSE 29721 was utilized, which contains 10 HCC samples and 10 normal adjacent tissue samples. Differentially expressed genes (DEGs) between two samples types were selected by t-test method...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043147/microrna-182-targets-foxf2-to-promote-the-development-of-triple-negative-breast-cancer
#15
J Yu, W Shen, B Gao, H Zhao, J Xu, B Gong
To explore the function of microRNA-182 (miR-182) on MCF7 and MDA-MB-231 cells behaviors, and possible mechanisms of triple-negative breast cancer (TNBC) development. Totally, 30 TNBC patients were enrolled to investigate the correlation between miR-182 expression and TNBC clinical indicators. miR-182 expression in TNBC tissues was measured by qRT-PCR, followed by bioinformatics methods and luciferase reporter assay to investigate whether FOXF2 was a direct target of miR-182. Besides, miR-182 mimics were transfected into MCF7 cells while miR-182 inhibitor into MDA-MB-231 cells, followed by cell proliferation and migration detection...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043146/microarray-analysis-of-long-non-coding-rnas-related-to-microrna-148b-in-gastric-cancer
#16
Y Song, J Sun, Y Xu, J Liu, P Gao, X Chen, J Zhao, Z Wang
The miR-148/152 family (miR-148a, miR-148b, miR-152) is differentially expressed in gastric cancer tissues and non-tumor tissues. Our previous studies indicated that miR-148/152 family is important in the tumorigenesis and development of gastric cancer. We also found several target genes that were regulated by the miR-148/152 family and several factors that could influence members of this family. However, the molecular mechanisms and function of this family in gastric cancer remain unclear. Recently, long non-coding RNAs (lncRNAs) have been found to play an important role in the pathogenesis of many diseases...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043145/cytotoxic-effect-of-oxaloacetate-on-hepg2-human-hepatic-carcinoma-cells-via-apoptosis-and-ros-accumulation
#17
Y Jiao, L Ji, Y Kuang, Q Yang
Oxaloacetate (OA) is one of the intermediates of the Krebs cycle. In addition to its role in energy production, OA may have other effects on the cell. We report here that OA could have a cell type dependent cytotoxic effect on the human hepatic carcinoma cell line HepG2 through induction of apoptosis and reactive oxygen species (ROS) accumulation. In our study, OA decreased the viability and colony formation of HepG2 cells and induced cell death. Caspase-3 activity was increased, the pro-apoptotic protein Bax was up-regulated, and the anti-apoptotic protein Bcl-2 was down-regulated in OA-treated HepG2 cells indicating that apoptosis through the intrinsic pathway was involved in the cell death...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043144/association-of-egfr-and-kras-mutations-with-expression-of-p-akt-dr5-and-dcr1-in-non-small-cell-lung-cancer
#18
X D Zhao, H B Deng, C L Lu, Y X Bao, X Lu, L L Deng
The activation of AKT is one of the causes of resistance to epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitors (TKIs). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combines with related receptors to trigger apoptosis or protect the cells against TRAIL apoptosis. This research focused on the association of EGFR and KRAS mutations with expression of AKT, p-AKT, DR5 and DcR1 in non-small cell lung cancer. 82 NSCLC patients were included in the study. xTAG liquichip techonolgy (xTAG-LCT) was applied to investigate the genetic mutation of EGFR and KRAS, Quantitative Real-time PCR was used to test the mRNA expression of AKT, DR5 and DcR1 and Western Blot was applied to test the protein expression of AKT, p-AKT, DR5, and DcR1...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043143/effects-of-ala-pdt-on-hpv16-immortalized-cervical-epithelial-cell
#19
S Wu, X Ren, Y Pan, D Guan, S Liu, X Zou, C Shi, Y-Z Li, Y Zhang
Current treatments for high-grade cervical intraepithelial neoplasia (CIN) and persistent infection with high-risk human papillomavirus (HR-HPV) type are mainly surgical interventions. However, such treatments are associated with adverse side effects and pose risks for future pregnancies. In order to reduce the requirement for excisional procedures, an effective and noninvasive therapy is needed for women at reproductive age. ALA-PDT has proved to be effective in the treatment of HPV-associated disease in several clinical investigations...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28043142/a-comprehensive-analysis-of-candidate-gene-signatures-in-oral-squamous-cell-carcinoma
#20
X Li, R Sun, X Geng, S Wang, D Zen, J Pei, J Yang, Y Fan, H Jiang, P Yang, C Li
Aimed to unravel the molecular mechanism of Oral squamous cell carcinoma (OSCC). With microarray dataset GSE30784, differentially expressed genes (DEGs) were identified between OSCC and control samples. The DEGs overlapped with genes obtained from online database MalaCards were determined as OSCCDEG, followed by Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A total of 5177 up-regulated and 6081 down-regulated DEGs were identified between OSCC and control. Out of the DEGs, 451 genes were overlapped with the 704 genes gained from MalaCards and regarded as "OSCCDEG"...
January 3, 2017: Neoplasma
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