Read by QxMD icon Read


X Song, J Q Wu, X F Yu, X S Yang, Y Yang
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor outcome. Because of lacking therapeutic targets, chemotherapy is the main treatment option for patients with TNBC. Overexpression of HDACs correlates with tumorigenesis, highlighting the potential of HDACs as therapeutic targets for TNBC. Here we demonstrate that trichostatin A (TSA, a HDAC inhibitor) selectively inhibits the proliferation of TNBC cell lines HCC1806 and HCC38 rather than a normal breast cell line MCF10A...
September 4, 2018: Neoplasma
B Smolkova, V Horvathova Kajabova, I Zmetakova, L Kalinkova, G Czanner, A Markova, A Furdova
It has been becoming increasingly clear, that epigenetic deregulation plays fundamental role in cancer. Although the understanding of molecular, genetic and transcriptional alterations involved in the initiation and progression of uveal melanoma (UM) has grown significantly in recent years, little attention has been paid to the role of epigenetic changes. In cancer, the epithelial-to-mesenchymal transition (EMT) enables trans-differentiation of epithelial tumor cells, endowing them with migratory and invasive properties...
September 4, 2018: Neoplasma
K Polakova, E Bandzuchova
HLA-G antigens and matrix metalloproteinases (MMPs) expressed in various tumors are involved in tumor growth and metastasis. In this study we investigated whether in cell lines of different origin exist some correlation between HLA-G and MMP expression. First, we examined MMP transcription in two choriocarcinoma cell lines: JEG-3 (HLA-G positive) and JAR (HLA-G negative). We discovered that both cell lines express similar panel of MMPs except MMP12. Transcript MMP12 was exclusively detected in HLA-G expressing JEG-3 cells but not in HLA-G deficient JAR cells...
September 4, 2018: Neoplasma
F Chen, H Chen, S Ke, L Zheng, X Zheng
Platinum-based chemotherapies have long been used as a standard treatment in ovarian cancer. However, cisplatin resistance is a major problem that restricts the use of cisplatin. Here, we aim to investigate the biological function of SLC27A2 and its underlying mechanisms in regulating chemo-resistance in ovarian cancer. Our findings show that SLC27A2 down-regulation in primary ovarian cancer tissues correlates chemo-resistance and poor patient survival in patient cohort. Significantly, we demonstrate that up-regulation of SLC27A2 by lentivirus-mediated p-SLC27A2 sensitizes ovarian cancer cells to cisplatin in vitro and in vivo via apoptosis...
September 4, 2018: Neoplasma
T Jiang, J Chen, X Huang, Y Li, L Zhong
Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) is the most fatal leukemia due to the BCR/ABL fusion protein. This fusion protein could induce the interleukin 6 (IL-6) expression in leukemia stem cells (LSCs), which sustain the stemness by binding IL-6R and activating Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. IL-6R was one of the targets of miR-451a, which was downregulated in LSCs by BCR/ABL. We aimed to investigate the relationship between miR-451a, IL-6R, and BCR/ABL in Ph+ ALL and create a strategy to treat this disease...
September 4, 2018: Neoplasma
N V Mitiushkina, M M Holmatov, A R Venina, V I Tiurin, G A Yanus, T N Sokolova, O S Yatsuk, O A Zaitseva, A O Ivantsov, E Sh Kuligina, A V Togo, E N Imyanitov
In contrast to other countries with predominantly White population, Russian smoking-related lung cancers (LC) are represented mainly by squamous cell carcinomas, while approximately a half of lung adenocarcinomas (AdCa) observed in this country are not related to tobacco consumption. Given that smoking significantly influences the probability of the presence of actionable mutations in LC, one would expect that Russian lung AdCa patients would differ from other Whites with respect to distribution of EGFR, ALK, KRAS and BRAF mutations...
September 4, 2018: Neoplasma
H Y Yang, C P Huang, M M Cao, Y F Wang, Y Liu
As a new kind of factors in regulating biological processes human cancers, long noncoding RNAs (lncRNAs) are attracting more and more attention from researchers. The lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) is transcribed from chromosome 16 on the opposite strand to the neighboring IRX5 gene. It was originally discovered to be abnormally expressed in CRC and was certified to be critical biomarker in many cancers. However, its biological function and mechanism underlying the tumorigenesis of cervical cancer are still waiting for further exploration...
September 4, 2018: Neoplasma
L Zadka, M Jerzy Kulus, K Piatek
ADAMs (a disintegrin and metalloproteinases) is a family of transmembrane proteins described for the first time in the 1990s. Their earliest known role was involvement in gametes fusion. Their adhesion properties in intercellular interactions suggested also the possibility of involvement in the tumor biology. The research conducted further at that time emphasized the importance of ADAM proteins in the regulation of neoplastic processes due to their influence on adhesion, cell migration, proteolysis and cell signaling...
September 4, 2018: Neoplasma
D P Wang, L L Gu, Q Xue, H Chen, G X Mao
The C-terminal binding protein 2 (CtBP2) is crucial for the activation of the Wnt/β-catenin pathway and regulates cellular processes of significance in multiple cancer cells. However, the role of CtBP2 in non-small cell lung cancer (NSCLC) remains uncertain. Our western blotting and immunohistochemistry assays revealed that CtBP2 expression was obviously increased in NSCLC tissues and cells. In addition, chi-square test and Kaplan-Meier analysis showed that overexpression of CtBP2 correlated with a more invasive tumor phenotype and poor prognosis...
September 4, 2018: Neoplasma
A Furdova, P Babal, D Kobzova, P Zahorjanova, K Kapitanova, M Sramka, G Kralik, R Furda, V Krasnik
This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001 - 2016. There were 81males (47.7%) and 89 females 89 (52.3%). The median overall follow-up time was three years. The median tumor volume at baseline was 0...
September 4, 2018: Neoplasma
W Wang, B Q Wu, G B Chen, Y Zhou, Z H Li, J L Zhang, Y L Ding, P Zhang, J Q Wang
The aim of this study was to comprehensively evaluate the associations of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer (CRC). We searched the English and Chinese databases and recruited case-control studies base on strict inclusion and exclusion criteria. The statistical analysis was performed by the Comprehensive Meta-analysis 2.0 (CMA 2.0) software. We identified 251 studies at the beginning and recruited 10 English studies after into this meta-analysis detailed review, including 9415 CRC patients and 14179 healthy controls...
September 4, 2018: Neoplasma
X H Liao, Z Xie, C N Guan
LY6K (lymphocyte antigen 6 complex locus K) is an anti-gene in non-small cell lung cancer (NSCLC) and miR-500a-3p promotes the progression of cancers. Evidence shows that the increase of miR-500a-3p caused LY6K to be suppressed. Here we hypothesized that miR-500a-3p may take part in the progression of NSCLC through targeting LY6K. miR-500a-3p expression levels in NSCLC specimens and cell lines were detected by quantitative real-time PCR (qRT-PCR). The mRNA and protein expression levels of LY6K in NSCLC specimens and cell lines were examined by qRT-PCR, immunohistochemistry and western blotting...
September 19, 2018: Neoplasma
F Luo, K Yang, Y Z Wang, D Lin
It is urgently needed to explore the clinical relevance of TMEM45B expression and Prostate cancer(PCa), and determine the predictive significance of TMEM45B as a biomarker for PCa patients.Patient-derived xenograft (PDX) model of PCa with different metastatic potential (LTL-418, LTL-313B, LTL-313H and LTL-331) were developed. The gene expression microarray of LTL-313H and LTL-313B, which derived from a single PCa patient, was performed to identify the candidate biomarker gene, TMRM45B. MSKCC and TCGA PCa patient cohorts were introduced to analyzed the clinical significance of TMEM45B expression...
September 19, 2018: Neoplasma
M Xu, Y Wang, H T He, Q Yang
MicroRNAs (miRNAs) are small noncoding RNAs approximately with 22 nucleotides. Accumulating evidence indicates that microRNAs are involved in carcinogenesis and tumor progression. Some recent investigations have also reported that several microRNAs could act as biomarkers in cancer diagnosis and prognosis. MicroRNA-589-5p (miR-589-5p) is a less studied microRNA, in this study, we explored its roles in hepatocellular carcinoma (HCC). We analyzed miR-589-5p expression in HCC tissues by sequencing data and proved the expression in liver cancer cell lines by quantitative real-time PCR (qRT-PCR)...
September 19, 2018: Neoplasma
J Li, N Shen, G P Bai, X S Huang
miRNAs are among the most important factors that regulate gene expression. According to bioinformatic analysis, miR-365a-3p was predicted to interact with the TET1 mRNA. We predicted that it might affect tumor biological processes through TET1. TET1 interference and miR-365a-3p inhibitor constructs were generated. qRT-PCR was used to verify the expression level of miR-365a-3p and TET1 in Hep-2 and BESB-2B cells. qRT-PCR and Western blot were used to confirm the TET1 expression level in Hep-2 and miR-365a-3p inhibitor cells...
September 19, 2018: Neoplasma
A Al Emam, D Arbon, M Jeeves, B Kysela
Ku70 protein in hetero-trimeric complex with Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) represents a critical component of the nonhomologous-end-joining (NHEJ), the major machinery of DSBs repair in mammalian cells. It has been previously shown that modulation of Ku70 acetylation by histone deacetylases (HDAC) inhibitors induced sensitization of cancer cells to chemotherapeutic agents. However, the effects of such modulation on the repair of Ionizing Radiation (IR)-induced DSBs and the importance of dynamic equilibrium of acetylation/deacetylation have not been studied in details...
September 19, 2018: Neoplasma
J Shu, S Li, Y B Chen, Q F Zhu, X H Yu
The aim of the research was to investigate the expression of lncRNA EPB41L4A-AS2 in non-small cell lung cancer (NSCLC) and evaluate its influence on the proliferation, invasion and apoptosis of NSCLC. A total of 56 NSCLC tissues and its corresponding adjacent tissues were collected. Quantitative Reverse transcription polymerase chain reaction (qRT-PCR) was performed to evaluate the lncRNA EPB41L4A-AS2 expression level in tissues and cell lines. Proliferating cell nuclear antigen (PCNA) protein level was determined by western blot assay...
September 19, 2018: Neoplasma
Z Zhang, N Y Jiang, R Y Guan, Y K Zhu, F Q Jiang, D Piao
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Imatinib mesylate was considered to be a breakthrough drug in clinical treatment of GIST, but GIST patients showed resistance against it. We aimed to identify critical microRNAs (miRNAs) related to imatinib resistance in imatinib-treated GIST patients. Microarray datasets under the accession number of GSE63159 and GSE45901 were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed miRNAs (DEMs) that are related to imatinib resistance were identified...
September 19, 2018: Neoplasma
L Roncati, F Piscioli
In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system no longer considers the mitotic count in the a or b T1 categorization for melanoma, but it adopts a sub-stratification based on the Breslow's depth. Today, the death burden of thin melanoma is still severe, despite of attempts for early screening. We believe that a bio-histological implementation may explain this evidence. It is generally accepted that melanoma progression includes two subsequent phases: the radial growth phases (RGP) and the vertical growth phase (VGP)...
September 19, 2018: Neoplasma
J M Zhao, W Cheng, X G He, Y L Liu, F F Wang, Y F Gao
Lung cancer remains the most common cause of tumor-related death worldwide. Recent studies have revealed that long non-coding RNAs (lncRNAs) are involved in the development of various cancers, including lung cancer. This study aimed to investigate the effect and the molecular basis of lncRNA PICART1 on lung cancer. We first assessed the PICART1 expression in lung cancer in vitro and vivo by qRT-PCR. Then the expression of PICART1 in SPC-A-1 and NCI-H1975 cell lines was inhibited and overexpressed by transient transfections...
September 19, 2018: Neoplasma
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"