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Journal of Radiation Research

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https://www.readbyqxmd.com/read/30239765/influence-of-risk-organ-based-tube-current-modulation-on-ct-induced-dna-double-strand-breaks-in-a-biological-phantom-model
#1
Michael Brand, Wolfgang Wuest, Matthias May, Michael Uder, Matthias Sommer
Techniques for dose reduction in computed tomography (CT) are receiving increasing attention. Lowering the tube current in front of the patient, known as risk-organ-based tube current modulation (RTM), represents a new approach. Physical dose parameters can determine the exposure but are not able to assess the biological-X-ray interactions. The purpose of this study was to establish a biological phantom model to evaluate the effect of RTM on X-ray-induced DNA double-strand breaks (DSBs). In breast phantoms and in the location of the spine in an Alderson phantom, isolated human blood lymphocytes were irradiated using a 128-slice CT scanner...
September 20, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30169853/cytokines-and-radiation-induced-pulmonary-injuries
#2
Anna Lierova, Marcela Jelicova, Marketa Nemcova, Magdalena Proksova, Jaroslav Pejchal, Lenka Zarybnicka, Zuzana Sinkorova
Radiation therapy is one of the most common treatment strategies for thorax malignancies. One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is the major dose-limiting organ for radiotherapy. That is because ionizing radiation produces reactive oxygen species that induce lesions, and not only is tumor tissue damaged, but overwhelming inflammatory lung damage can occur in the alveolar epithelium and capillary endothelium. This damage may result in radiation-induced pneumonitis and/or fibrosis...
August 31, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30165446/high-susceptibility-of-mouse-newborns-to-delayed-appearance-of-dna-double-strand-breaks-in-neural-stem-progenitor-cells-exposed-to-ionizing-radiation
#3
Kenta Sakaguchi, Kazunori Shiraishi, Seiji Kodama
Fetal brains are known to be extremely sensitive to ionizing radiation, which can induce structural and functional defects in the developing brain. However, there is less data on the effects of radiation on newborn brains. To determine the radiation sensitivity in newborn brains, we determined the number of DNA double-strand breaks (DSBs) appearing at later stage post-irradiation in neural stem/progenitor cells (NSPCs) of mouse newborns <3 days old, and compared it with the numbers of DSBs of fetal, 1-week-neonate, 2-week-neonate, and adult mice...
August 25, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30165406/determining-survival-fractions-of-saccharomyces-cerevisiae-in-response-to-ionizing-radiation-in-liquid-culture
#4
Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Wenjian Li, Dong Lu
Saccharomyces cerevisiae survival fractions (SFs) in response to X-ray radiation were determined by two new methods: an OD600-based method and a 96-well method. For the OD600-based method, cells were exposed to various X-ray doses and inoculated into fresh medium: a lower biomass accumulated, indicating fewer surviving cells within the investigated dose range (0-100 Gy). For the 96-well method, diluent containing ~0-100 cells was equally divided into 96 droplets and respectively inoculated into 96 wells containing 200 μl of broth: fewer wells without S...
August 25, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30137391/japanese-structure-survey-of-radiation-oncology-in-2010
#5
Hodaka Numasaki, Teruki Teshima, Tetsuo Nishimura, Keizo Akuta, Yutaka Ando, Hiroshi Ikeda, Norihiko Kamikonya, Masahiko Koizumi, Tomonari Sasaki, Kenji Sekiguchi, Masao Tago, Atsuro Terahara, Katsumasa Nakamura, Masamichi Nishio, Masao Murakami, Yoshimasa Mori, Kazuhiko Ogawa
We evaluated the evolving structure of radiation oncology in Japan in terms of equipment, personnel, patient load, and geographic distribution to identify and overcome any existing limitations. From March 2011 to June 2013, the Japanese Society for Radiation Oncology conducted a questionnaire based on the Japanese national structure survey of radiation oncology in 2010. Data were analyzed based on the institutional stratification by the annual number of new patients treated with radiotherapy per institution...
August 21, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30124892/appropriate-radiation-dose-for-symptomatic-relief-and-local-control-in-patients-with-adult-t-cell-leukemia-lymphoma
#6
Hitoshi Maemoto, Takuro Ariga, Sawako Nakachi, Takafumi Toita, Seiji Hashimoto, Joichi Heianna, Hideki Shiina, Takeaki Kusada, Wataru Makino, Yasumasa Kakinohana, Takuya Miyagi, Yuichi Yamamoto, Satoko Morishima, Hiroaki Masuzaki, Sadayuki Murayama
Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell neoplasm that occurs only in patients with human T-cell leukemia virus type 1. No large study or randomized trial investigating radiotherapy (RT) for ATL has been performed. We retrospectively reviewed 55 courses of RT for 41 consecutive patients with ATL who underwent RT between 2000 and 2016 at our institutions. The results showed that RT for local ATL lesions can achieve symptomatic improvement in 92% of cases. Local remission, either complete remission (CR) or partial response (PR), was achieved in 100% of the patients (CR: 89%, PR: 11%) with ≥40 Gy irradiation...
August 17, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30124896/measurement-of-90sr-radioactivity-in-cesium-hot-particles-originating-from-the-fukushima-nuclear-power-plant-accident
#7
Shunsuke Nakamura, Tsuyoshi Kajimoto, Kenichi Tanaka, Hideo Yoshida, Makoto Maeda, Satoru Endo
A method for the determination of 134+137Cs and 90Sr in cesium hot particles (Cs-HPs) originating from the Fukushima Daiichi Nuclear Power Plant accident has been developed. The method depends on a response function that is calculated by PHITS code and fitted to the beta-ray spectrum measured with a Si-detector. The 134+137Cs radioactivity in the Cs-HPs was consistent with that measured by a Ge-detector, thus confirming the reliability of the method. The 90Sr/137Cs ratios, which ranged from 0.001 to 0.0042, were consistent with a 90Sr/137Cs inventory ratio for contaminated soil samples...
August 15, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30124891/relationship-between-pressure-levels-on-the-occipital-region-and-intrafraction-motion-using-an-individualized-head-support-for-intracranial-treatment
#8
Hiroki Inata, Yuta Kuribayashi, Azusa Katakami, Noritaka Sodeoka, Shigeki Nakayama, Osamu Nishizaki
The purpose of this study was to evaluate the relationship between pressure on the occipital region and intrafraction motion using an individualized vacuum pillow and a thermoplastic mask for intracranial treatment. We calculated head displacement during treatment from 8811 image verifications in 59 patients and divided them into two groups according to the magnitude of the mean and standard deviation (SD) of the displacement in the 59 patients. Pressure was compared between the small (n = 29) and large (n = 30) displacement groups using Welch's t-test for the mean and SD of displacement...
August 14, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30124886/epithelial-mesenchymal-transition-in-non-targeted-lung-tissues-of-kunming-mice-exposed-to-x-rays-is-suppressed-by-celecoxib
#9
Wentao Hu, Hailong Pei, Fang Sun, Pengfei Li, Jing Nie, Bingyan Li, Tom K Hei, Guangming Zhou
Lung cancer is one of the highest health risks caused by ionizing radiation, which induces both direct effects and non-targeted effects. However, whether radiation-induced non-targeted effects result in epithelial-mesenchymal transition, a critical process during tumorigenesis, in non-targeted lung tissues remains unknown. In the present study, Kunming mice were subjected to whole-body, cranial or local abdominal irradiation of single-dose or fractionated 4 Gy X-rays, and the expressions of epithelial-mesenchymal transition markers in non-targeted lung tissues were assessed by both qRT-PCR and immunofluorescent staining...
August 14, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30124879/radiation-quality-effects-alteration-in-cox-2-pathway-to-trigger-radiation-induced-bystander-response-in-a549-lung-carcinoma-cells
#10
Alisa Kobayashi, Teruaki Konishi
This study aimed to determine whether the radiation-induced bystander effect (RIBE) is affected by radiation quality. To mimic the different radiation qualities of the direct action (D)/indirect action (ID) ratio, A549 cells were exposed to X-rays, with either 100 mM of the radical scavenger, thio-urea (TU+), or null (TU-). Biological responses in irradiated and bystander cells were compared at equal lethal effects of a 6% survival dose, which was estimated from the survival curves to be 8 Gy and 5 Gy for TU+ and TU-, respectively...
August 14, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30102326/impact-of-prophylactic-cranial-irradiation-on-pattern-of-brain-metastases-as-a-first-recurrence-site-for-limited-disease-small-cell-lung-cancer
#11
Masaki Nakamura, Masakatsu Onozawa, Atsushi Motegi, Hidehiro Hojo, Sadamoto Zenda, Naoki Nakamura, Hibiki Udagawa, Keisuke Kirita, Shingo Matsumoto, Shigeki Umemura, Kiyotaka Yoh, Seiji Niho, Koichi Goto, Tetsuo Akimoto
This study sought to evaluate the impact of prophylactic cranial irradiation (PCI) on the pattern of brain recurrence after radical treatment in patients with limited-disease small-cell lung cancer (LD-SCLC). Patients treated with radiotherapy and chemotherapy between January 2006 and December 2014 at a single institution were retrospectively examined. Radiotherapy was performed using accelerated hyperfractionated radiotherapy (twice daily, 45 Gy in 30 fractions) or conventional fractionated radiotherapy (once daily, 50 Gy in 25 fractions)...
August 9, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30102325/dosimetric-comparison-between-dual-isocentric-dynamic-conformal-arc-therapy-and-mono-isocentric-volumetric-modulated-arc-therapy-for-two-large-brain-metastases
#12
Megumi Uto, Takashi Mizowaki, Kengo Ogura, Nobutaka Mukumoto, Tomohiro Katagiri, Keiichi Takehana, Masahiro Hiraoka
Mono-isocentric volumetric-modulated arc therapy (VMAT) can be used to treat multiple brain metastases. It remains unknown whether mono-isocentric VMAT can improve the dose distribution compared with dual-isocentric dynamic conformal arc therapy (DCAT), especially for two brain metastases. We compared the dose distribution between dual-isocentric DCAT and mono-isocentric VMAT for two large brain metastases, and analyzed the relationship between the distance between the two targets and the difference in dose distribution...
August 9, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30085200/a-validated-proton-beam-therapy-patch-field-protocol-for-effective-treatment-of-large-hepatocellular-carcinoma
#13
Masatoshi Nakamura, Nobuyoshi Fukumitsu, Satoshi Kamizawa, Haruko Numajiri, Keiko Nemoto Murofushi, Kayoko Ohnishi, Teruhito Aihara, Hitoshi Ishikawa, Toshiyuki Okumura, Koji Tsuboi, Hideyuki Sakurai
Development of a curative local treatment for large hepatocellular carcinoma (HCC) is an important issue. Here, we investigated the dose homogeneity, safety and antitumor effectiveness of proton beam therapy (PBT) using a patch-field technique for large HCC. Data from nine patients (aged 52-79 years) with large HCC treated with patch-field PBT were investigated. The cranial-caudal diameters of the clinical target volumes (CTVs) were 15.0-18.6 cm (median 15.9). The CTV was divided cranially and caudally while both isocenters were aligned along the cranial-caudal axis and overlap of the cranial and caudal irradiation fields was set at 0-0...
August 6, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30085197/comparison-of-elective-nodal-irradiation-and-involved-field-irradiation-in-esophageal-squamous-cell-carcinoma-a-meta-analysis
#14
Yun-Jie Cheng, Shao-Wu Jing, Ling-Ling Zhu, Jun Wang, Long Wang, Qing Liu, Cong-Rong Yang, Yi Wang, Feng Cao, Wen-Peng Jiao, Ya-Jing Wu
It remains controversial whether radical radiotherapy in patients with esophageal squamous cell carcinoma (ESCC) still requires elective nodal irradiation (ENI), or only involved-field irradiation (IFI). In this study, a meta-analysis was conducted to compare ENI and IFI in the treatment of ESCC, in order to provide guidance for clinical practice. Literature on the use of ENI and IFI in the treatment of ESCC was retrieved, and the last access date was 31 December 2017. A meta-analysis was performed to evaluate the relative advantages and disadvantages of using ENI and IFI...
August 6, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30085157/composite-qa-for-intensity-modulated-radiation-therapy-using-individual-volume-based-3d-gamma-indices
#15
Ce Han, Wenliang Yu, Xiaomin Zheng, Yongqiang Zhou, Changfei Gong, Congying Xie, Xiance Jin
The aim of this study was to investigate the feasibility and sensitivity of using individual volume-based 3D gamma indices for composite dose-volume histogram (DVH)-based intensity-modulated radiation therapy (IMRT) quality assurance (QA). Composite IMRT QA for 15 cervical cancer patients was performed with ArcCHECK. The percentage dosimetric errors (%DEs) of DVH metrics when comparing treatment planning system and QA-reconstructed dose distribution, percentage gamma passing rates (%GPs) with different criteria for individual volumes and global gamma indices were evaluated, as well as their correlations...
July 31, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30085048/a-pilot-study-of-highly-hypofractionated-intensity-modulated-radiation-therapy-over-3-weeks-for-localized-prostate-cancer
#16
Kiyonao Nakamura, Itaru Ikeda, Haruo Inokuchi, Kenji Takayama, Takahiro Inoue, Tomomi Kamba, Osamu Ogawa, Masahiro Hiraoka, Takashi Mizowaki
The purpose of this pilot study was to evaluate the feasibility of highly hypofractionated intensity-modulated radiation therapy (IMRT) in 15 fractions over 3 weeks for treating localized prostate cancer based on prostate position-based image-guided radiation therapy. Twenty-five patients with National Comprehensive Cancer Network (NCCN) very low- to unfavorable intermediate-risk prostate cancer were enrolled in this study from April 2014 to September 2015 to receive highly hypofractionated IMRT (without intraprostatic fiducial markers) delivering 54 Gy in 15 fractions over 3 weeks...
July 31, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30085098/the-effect-of-hyperthermia-on-the-dna-damage-response-induced-by-%C3%AE-rays-as-determined-through-in-situ-cell-tracking
#17
Qibin Fu, Jing Wang, Tuchen Huang
Hyperthermia (HT) acts as a cancer treatment by direct cell killing, radiosensitization, and promotion of tumor reoxygenation. The sensor proteins of the DNA damage response (DDR) are the direct targets of HT. However, the spatiotemporal properties of sensor proteins under HT are still unclear. Therefore, investigating the impact of HT on sensor proteins is of great importance. In the present study, the human fibrosarcoma cell line HT1080 stably transfected with 53BP1-GFP [the DDR protein 53BP1 fused to green fluorescent protein (GFP)] was used to investigate the real-time cellular response to DNA double-strand breaks (DSBs) induced by γ-rays...
July 30, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30085076/clinical-features-of-prostate-specific-antigen-bounce-after-125i-brachytherapy-for-prostate-cancer
#18
Katsumaro Kubo, Koichi Wadasaki, Tomoki Kimura, Yuji Murakami, Mitsuru Kajiwara, Jun Teishima, Akio Matsubara, Yasushi Nagata
The aim of this study was to analyse the clinical features of prostate-specific antigen (PSA) bounce and the difference between biochemical failure and large-magnitude PSA bounce. The cases of 352 patients with prostate cancer who underwent brachytherapy were analysed. PSA bounce was defined as an increase in PSA of ≥0.2 ng/ml above an initial PSA nadir, with subsequent decline to or below that initial nadir without treatment. PSA bounce +2 was defined as an increase in PSA of ≥2.0 ng/ml above the nadir with subsequent decline to or below that initial nadir without treatment...
July 30, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30053071/radiation-therapy-for-deep-periocular-cancer-treatments-when-protons-are-unavailable-is-combining-electrons-and-orthovoltage-therapy-beneficial
#19
Kevin Martell, Yannick Poirier, Tiezhi Zhang, Alana Hudson, David Spencer, Ferenc Jacso, Richard Hayashi, Robyn Banerjee, Rao Khan, Nathan Wolfe, Jon-Paul Voroney
Deep periocular cancers can be difficult to plan and treat with radiation, given the difficulties in apposing bolus to skin, and the proximity to the retina and other optic structures. We sought to compare the combination of electrons and orthovoltage therapy (OBE) with existing modalities for these lesions. Four cases-a retro-orbital melanoma (Case 1) and basal cell carcinomas, extending across the eyelid (Case 2) or along the medial canthus (Cases 3-4)-were selected for comparison. In each case, radiotherapy plans for electron only, 70% electron and 30% orthovoltage (OBE), volumetric-modulated arc therapy (VMAT), conformal arc, and protons were compared...
July 25, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30053184/dosimetric-comparison-of-three-dimensional-conformal-radiotherapy-versus-volumetric-arc-radiotherapy-in-cervical-cancer-treatment-applying-the-central-shielding-principle-to-modern-technology
#20
Tomoaki Tamaki, Ryuta Hirai, Mitsunobu Igari, Yu Kumazaki, Shin-Ei Noda, Yoshiyuki Suzuki, Shingo Kato
This study evaluated the feasibility of applying volumetric-arc radiotherapy (VMAT) in standard curative radiotherapy for non-bulky cervical cancer using the central-shielding principle. Whole-pelvis irradiation of 20 Gy and central-shielding pelvis irradiation of 30 Gy, both in 2 Gy fractions, were created using 3D conformal radiotherapy (3DCRT) with a standard midline block or VMAT. Composite dose distributions and DVH parameters were compared first in a simple phantom model and then in 10 clinical cases of Stage I-II cervical cancer...
July 21, 2018: Journal of Radiation Research
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