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Journal of Radiation Research

Zhu-Yue Chen, Ying-Ying Hu, Xiao-Fan Hu, Long-Xian Cheng
Recently, multipotent mesenchymal stromal cell (MSC) treatment has attracted special attention as a new alternative strategy for stimulating regeneration. Irradiation myocardial fibrosis (IMF) is a major complication associated with total body irradiation for hematopoietic stem cell transplantation, nuclear accidents, and thoracic radiotherapy for lung cancer, esophageal cancer, proximal gastric cancer, breast cancer, thymoma, and lymphoma. The aim of the present study was to assess the therapeutic paracrine effects of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in the cell model of IMF...
July 12, 2018: Journal of Radiation Research
Hiroaki Matsubara, Kumiko Karasawa, Wataru Furuichi, Mitsuji Wakaisami, Shintaro Shiba, Masaru Wakatsuki, Tokuhiko Omatsu, Taku Inaniwa, Shigekazu Fukuda, Tadashi Kamada
The dose distribution of passive and scanning irradiation for carbon-ion radiotherapy for breast cancer was compared in order to determine the preferred treatment method. Eleven Japanese patients who received carbon-ion radiotherapy for breast cancer were retrospectively analyzed. The original clinical plans were used for the passive irradiation method, while the plans for the scanning irradiation method were more recently made. Statistical analysis suggested that there was no significant difference in superiority in terms of dose distribution between the passive and scanning irradiation methods...
July 11, 2018: Journal of Radiation Research
Takafumi Toita, Tatsuya Ohno, Hitoshi Ikushima, Tetsuo Nishimura, Takashi Uno, Kazuhiko Ogawa, Hiroshi Onishi, Takushi Dokiya, Jun Itami
To review the current status of, and labor expended for (in terms of time required), intracavitary brachytherapy (ICBT) in definitive radiotherapy/chemoradiotherapy for cervical cancer patients, two national surveys were performed. The first survey was conducted between July and August 2016 and consisted of a questionnaire of 12 items regarding ICBT procedures for cervical cancer, which was sent to 173 centers installed with high-dose-rate remote after-loading brachytherapy systems. Between November and December 2016, another survey was performed in 79 centers to evaluate labor required for ICBT procedures in terms of time spent and number of staff involved...
July 6, 2018: Journal of Radiation Research
Shin Koyama, Eijiro Narita, Naoki Shinohara, Junji Miyakoshi
High-dose ionizing radiation is sufficient for breaking DNA strands, leading to cell death and mutations. By contrast, the effects of fractionated ionizing radiation on human-derived cells remain unclear. To better understand the genotoxic effects of fractionated ionizing radiation, as well as the cellular recovery rate, we investigated the frequency of micronucleus (MN) formation in various types of human cells. We irradiated cells with fractionated X-ray doses of 2 Gy at a rate of 0.0635 Gy/min, separated into two to eight smaller doses...
June 29, 2018: Journal of Radiation Research
Masahiro Onishi, Noriyuki Okonogi, Takahiro Oike, Yuya Yoshimoto, Hiro Sato, Yoshiyuki Suzuki, Tadashi Kamada, Takashi Nakano
Anti-tumor immunity modulates the local effects of radiation therapy. High mobility group box 1 (HMGB1) plays a pivotal role in activating antigen-specific T-cell responses. Here, we examined the relationship between linear energy transfer (LET) and HMGB1 release. We assessed the proportions of KYSE-70, HeLa and SiHa cells surviving after carbon-ion (C-ion) beam irradiation with different LET values, using a clonogenic assay. The D10, the dose at which 10% of cells survived, was calculated using a linear-quadratic model...
June 27, 2018: Journal of Radiation Research
Ilsung Cho, Young Seok Seo, WonGyun Jung, Mi-Sook Kim
The Korea Heavy Ion Medical Accelerator project focuses on the development of medical accelerator facilities for delivering carbon-ion beams to cancer patients. The purpose of the present study was to estimate the clinical need for carbon-ion therapy in Korea. Seven tumor sites, namely head and neck, liver, lung, colon and rectum, prostate, bone and soft tissue, and pancreas were selected as eligible sites for receiving carbon-ion radiotherapy (RT) by radiation oncologists of the Korea Institute of Radiological and Medical Sciences...
June 25, 2018: Journal of Radiation Research
Yuji Murakami, Yoichi Hamai, Manabu Emi, Jun Hihara, Nobuki Imano, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Tomoki Kimura, Morihito Okada, Yasushi Nagata
This study retrospectively evaluated the long-term results of neoadjuvant chemoradiotherapy (NCRT) followed by esophagectomy for the patients with resectable, locally advanced esophageal squamous cell carcinoma (ESCC). Altogether, 49 patients treated from 2008 to 2012 were analyzed. Chemotherapy consisted of 5-fluorouracil and cisplatin. Radiotherapy was performed with a total dose of 40 Gy in 20 fractions for primary tumor, metastatic lymph nodes, and elective nodal area. Subsequently, transthoracic esophagectomy with extensive lymphadenectomy was performed...
June 25, 2018: Journal of Radiation Research
Sei Hwan You, Mee Yon Cho, Joon Hyung Sohn, Chang Geol Lee
Pancreatic radiation effect (PRE) can be a component of gastrointestinal tract (GIT) radiotoxicity. This inter-organ correlation between the GIT and the pancreas was assessed through a rat model. Separate local irradiation to the abdomen and the pelvis was applied concurrently for 8-week-old male Sprague Dawley rats. Abdominal irradiation was categorized into pancreatic shield (PS) and non-pancreatic shield (NPS) irradiation. After 5 Gy and 15 Gy irradiation, the rectal mucosa was analyzed at the first week (early phase, Ep) and the 14th week (late phase, Lp)...
June 12, 2018: Journal of Radiation Research
Hidetoshi Shimizu, Koji Sasaki, Takashi Kubota, Hiroshi Fukuma, Takahiro Aoyama, Tohru Iwata, Hiroyuki Tachibana, Takeshi Kodaira
Several studies have reported changes in dose distribution and delivery time based on the value of specific planning parameters [field width (FW), pitch, and modulation factor (MF)] in tomotherapy. However, the variation in the parameters between different facilities is unknown. The purpose of this study was to determine standard values of the above parameters for cases of head and neck cancer (HNC) and prostate cancer (PC) in Japan. In this survey, a web-based questionnaire was sent to 48 facilities performing radiation therapy with tomotherapy in March 2016...
June 2, 2018: Journal of Radiation Research
Hisashi Nakano, Kazumasa Minami, Masashi Yagi, Hiromasa Imaizumi, Yuki Otani, Shinichi Inoue, Masaaki Takashina, Yuji Seo, Yutaka Takahashi, Iori Sumida, Kazuhiko Ogawa, Masahiko Koizumi
Flattening filter-free (FFF) photon beams minimize the intrafraction motion of tumors, and this feature is useful in pulmonary malignancies, such as non-small-cell lung cancer (NSCLC). However, the radiobiological effects of such beams on NSCLC cells, which are often treated with stereotactic body radiotherapy (SBRT), have not been investigated sufficiently. Although cell motility may be promoted by photon beams with a low dose, the relationship between cell motility and the dose rate of photon beams has not been evaluated...
May 30, 2018: Journal of Radiation Research
Marcus Unverricht-Yeboah, Ulrich Giesen, Ralf Kriehuber
Gene expression analysis was carried out in Jurkat cells in order to identify candidate genes showing significant gene expression alterations allowing robust discrimination of the Auger emitter 123I, incorporated into the DNA as 123I-iododeoxyuridine (123IUdR), from α- and γ-radiation. The γ-H2AX foci assay was used to determine equi-effect doses or activity, and gene expression analysis was carried out at similar levels of foci induction. Comparative gene expression analysis was performed employing whole human genome DNA microarrays...
May 25, 2018: Journal of Radiation Research
Shunta Jinno, Hidenobu Tachibana, Shunsuke Moriya, Norifumi Mizuno, Ryo Takahashi, Tatsuya Kamima, Satoru Ishibashi, Masanori Sato
In inhomogeneous media, there is often a large systematic difference in the dose between the conventional Clarkson algorithm (C-Clarkson) for independent calculation verification and the superposition-based algorithms of treatment planning systems (TPSs). These treatment site-dependent differences increase the complexity of the radiotherapy planning secondary check. We developed a simple and effective method of heterogeneity correction integrated with the Clarkson algorithm (L-Clarkson) to account for the effects of heterogeneity in the lateral dimension, and performed a multi-institutional study to evaluate the effectiveness of the method...
May 21, 2018: Journal of Radiation Research
Naoki Nakamura, Hidehiro Hojo, Kazuya Inoue, Kenji Hotta, Sadamoto Zenda, Hiromi Baba, Masakatsu Onozawa, Atsushi Motegi, Masaki Nakamura, Yuichi Kibe, Tetsuo Akimoto
This study aimed to examine late radiological changes after proton beam therapy (PBT) for early-stage non-small cell lung cancer (NSCLC) and to clarify correlations between mass-like radiological changes and patient characteristics. CT scans of patients who underwent passive scattering PBT for T1-2N0M0 NSCLC were analyzed retrospectively. Patients were considered eligible if follow-up CT was performed for at least 2 years, with no definite evidence of local recurrence. The following five periods were defined: (i) 6-12 months, (ii) 12-24 months, (iii) 24-36 months, (iv) 36-48 months and (v) 48-60 months after PBT...
May 21, 2018: Journal of Radiation Research
Yukihisa Tamaki, Tomoko Itazawa, Takafumi Komiyama, Yasumasa Nishimura, Yuko Nakayama, Hiroyuki Ito, Yasuhisa Ohde, Masahiko Kusumoto, Shuji Sakai, Kenji Suzuki, Hirokazu Watanabe, Hisao Asamura
No abstract text is available yet for this article.
May 19, 2018: Journal of Radiation Research
Chawalit Lertbutsayanukul, Sarin Kitpanit, Anussara Prayongrat, Danita Kannarunimit, Buntipa Netsawang, Chakkapong Chakkabat
This study aimed to validate previously reported dosimetric parameters, including thyroid volume, mean dose, and percentage thyroid volume, receiving at least 40, 45 and 50 Gy (V40, V45 and V50), absolute thyroid volume spared (VS) from 45, 50 and 60 Gy (VS45, VS50 and VS60), and clinical factors affecting the development of radiation-induced hypothyroidism (RHT). A post hoc analysis was performed in 178 euthyroid nasopharyngeal cancer (NPC) patients from a Phase III study comparing sequential versus simultaneous-integrated boost intensity-modulated radiation therapy...
May 10, 2018: Journal of Radiation Research
Nana Sato, Makiko Orita, Yasuyuki Taira, Noboru Takamura
No abstract text is available yet for this article.
April 30, 2018: Journal of Radiation Research
Hiraku Iramina, Takumi Hamaguchi, Mitsuhiro Nakamura, Takashi Mizowaki, Ikuo Kanno
We evaluated two dual-energy cone-beam computed tomography (DE-CBCT) methodologies for a bench-top micro-CBCT system to reduce metal artifacts on reconstructed images. Two filter-based DE-CBCT methodologies were tested: (i) alternative spectral switching and (ii) simultaneous beam splitting. We employed filters of 0.6-mm-thick tin and 0.1-mm-thick tungsten to generate high- and low-energy spectra from 120 kVp X-rays, respectively. The spectral switching method was imitated by two half scans with different filters (pseudo-switching)...
April 30, 2018: Journal of Radiation Research
Aydemir Kale, Özcan Piskin, Yilmaz Bas, Bengü Gülhan Aydin, Murat Can, Özlem Elmas, Çagatay Büyükuysal
Extensive research has been focused on radiation-induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of quercetin in an experimental radiation-induced brain injury. A total of 32 adult male Wistar-Albino rats were randomly divided into four groups (control, quercetin, radiation, and radiation+quercetin groups, with eight rats in each group). Doses (50 mg/kg) of quercetin were administered to the animals in the quercetin and radiation+quercetin groups; radiation and radiation+quercetin groups were exposed to a dose of 20 Gy to the cranium region...
April 24, 2018: Journal of Radiation Research
Yu Murakami, Masahiro Nakano, Masahiro Yoshida, Hideaki Hirashima, Fumiya Nakamura, Junichi Fukunaga, Taka-Aki Hirose, Yasuo Yoshioka, Masahiko Oguchi, Hideki Hirata
The present study compares dosimetric parameters between volumetric-modulated arc therapy (VMAT) and 3D conformal radiation therapy (3D-CRT) in lung tumors adjacent to the chest wall treated with stereotactic body radiation therapy (SBRT). The study focused on the radiation dose to the chest wall of 16 patients who had developed radiation-induced rib fractures (RIRF) after SBRT using 3D-CRT. The targets in all patients were partially overlapping with the fractured ribs, and the median overlapping rib-PTV distance was 0...
May 1, 2018: Journal of Radiation Research
Ryosuke Mori, Yusuke Matsuya, Yuji Yoshii, Hiroyuki Date
DNA double-strand breaks (DSBs) are thought to be the main cause of cell death after irradiation. In this study, we estimated the probability distribution of the number of DSBs per cell nucleus by considering the DNA amount in a cell nucleus (which depends on the cell cycle) and the statistical variation in the energy imparted to the cell nucleus by X-ray irradiation. The probability estimation of DSB induction was made following these procedures: (i) making use of the Chinese Hamster Ovary (CHO)-K1 cell line as the target example, the amounts of DNA per nucleus in the logarithmic and the plateau phases of the growth curve were measured by flow cytometry with propidium iodide (PI) dyeing; (ii) the probability distribution of the DSB number per cell nucleus for each phase after irradiation with 1...
May 1, 2018: Journal of Radiation Research
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