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Journal of Radiation Research

Tetsuo Nakajima, Bing Wang, Tetsuya Ono, Yoshihiko Uehara, Shingo Nakamura, Kazuaki Ichinohe, Ignacia Braga-Tanaka, Satoshi Tanaka, Kimio Tanaka, Mitsuru Nenoi
No abstract text is available yet for this article.
February 15, 2017: Journal of Radiation Research
Junsang Cho, Wonjoong Cheon, Sanghee Ahn, Hyunuk Jung, Heesoon Sheen, Hee Chul Park, Youngyih Han
No abstract text is available yet for this article.
February 15, 2017: Journal of Radiation Research
Anussara Prayongrat, Chakkapong Chakkabat, Danita Kannarunimit, Pokrath Hansasuta, Chawalit Lertbutsayanukul
No abstract text is available yet for this article.
February 14, 2017: Journal of Radiation Research
Yuki Tamari, Genro Kashino, Hiromu Mori
No abstract text is available yet for this article.
February 13, 2017: Journal of Radiation Research
Iori Sumida, Hajime Yamaguchi, Indra J Das, Hisao Kizaki, Keiko Aboshi, Mari Tsujii, Yuji Yamada, Keisuke Tamari, Yuji Seo, Fumiaki Isohashi, Yasuo Yoshioka, Kazuhiko Ogawa
No abstract text is available yet for this article.
February 13, 2017: Journal of Radiation Research
Taro Murai, Yukiko Hattori, Chikao Sugie, Hiromitsu Iwata, Michio Iwabuchi, Yuta Shibamoto
No abstract text is available yet for this article.
February 13, 2017: Journal of Radiation Research
Yoshiki Takayama, Noriyuki Kadoya, Takaya Yamamoto, Kengo Ito, Mizuki Chiba, Kousei Fujiwara, Yuya Miyasaka, Suguru Dobashi, Kiyokazu Sato, Ken Takeda, Keiichi Jingu
No abstract text is available yet for this article.
February 2, 2017: Journal of Radiation Research
Seo Hee Choi, Jee Suk Chang, Nam Kyu Kim, Joon Seok Lim, Byung So Min, Hyuk Hur, Sang Joon Shin, Joong Bae Ahn, Yong Bae Kim, Woong Sub Koom
The aim of this study was to report the clinical results of reduced pelvic field radiotherapy (RT), excluding the anastomotic site, after total mesorectal excision in selected patients with rectal cancer. Between 2011 and 2014, 99 patients underwent upfront surgery for clinically less-advanced tumors but were finally diagnosed as pT3/N+. Among them, 50 patients with mid-upper rectal cancer who received postoperative RT with a reduced pelvic field were included in this retrospective review. This group was composed of patients with high seated tumors, complete resection with a clear circumferential resection margin, and no complication during surgery...
January 24, 2017: Journal of Radiation Research
Ji-Hye Yim, Jung Mi Yun, Ji Young Kim, In Kyung Lee, Seon Young Nam, Cha Soon Kim
Ionizing radiation causes biological damage that leads to severe health effects. However, the effects and subsequent health implications caused by exposure to low-dose radiation are unclear. The objective of this study was to determine phosphoprotein profiles in normal human fibroblast cell lines in response to low-dose and high-dose γ-radiation. We examined the cellular response in MRC-5 cells 0.5 h after exposure to 0.05 or 2 Gy. Using 1318 antibodies by antibody array, we observed ≥1.3-fold increases in a number of identified phosphoproteins in cells subjected to low-dose (0...
January 24, 2017: Journal of Radiation Research
Sanziana R I Schiopu, Gregor Habl, Matthias Häfner, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
The aim of this study was to describe early and late toxicity, survival and local control in 45 patients with primary brain tumors treated with helical tomotherapy craniospinal irradiation (HT-CSI). From 2006 to 2014, 45 patients with central nervous system malignancies were treated with HT-CSI. The most common tumors were medulloblastoma in 20 patients, ependymoma in 10 patients, intracranial germinoma (ICG) in 7 patients, and primitive neuroectodermal tumor in 4 patients. Hematological toxicity during treatment included leukopenia Grades 1-4 (6...
January 17, 2017: Journal of Radiation Research
Atiyeh Ebrahimi Khankook, Hashem Miri Hakimabad, Laleh Rafat Motavalli
Computational models of the human body have gradually become crucial in the evaluation of doses absorbed by organs. However, individuals may differ considerably in terms of organ size and shape. In this study, the authors sought to determine the energy-dependent standard deviations due to lung size of the dose absorbed by the lung during external photon and neutron beam exposures. One hundred lungs with different masses were prepared and located in an adult male International Commission on Radiological Protection (ICRP) reference phantom...
January 10, 2017: Journal of Radiation Research
Feng Ru Tang, Weng Keong Loke, Boo Cheong Khoo
Animal experimental studies indicate that acute or chronic low-dose ionizing radiation (LDIR) (≤100 mSv) or low-dose-rate ionizing radiation (LDRIR) (<6 mSv/h) exposures may be harmful. It induces genetic and epigenetic changes and is associated with a range of physiological disturbances that includes altered immune system, abnormal brain development with resultant cognitive impairment, cataractogenesis, abnormal embryonic development, circulatory diseases, weight gain, premature menopause in female animals, tumorigenesis and shortened lifespan...
January 10, 2017: Journal of Radiation Research
Yu Ohkubo, Yoshihiro Saito, Hiroki Ushijima, Masahiro Onishi, Tomoko Kazumoto, Jun-Ichi Saitoh, Nobuko Kubota, Hirofumi Kobayashi, Nobuo Maseki, Yu Nishimura, Masafumi Kurosumi
This study aimed to assess the long-term outcomes of radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-seven patients with Stage I gastric MALT lymphoma were treated with radiotherapy from 1999 to 2010. The median age was 65 years (range: 31-84). Fifteen patients were Helicobacter pylori-negative. Thirteen patients were treated with definitive radiotherapy alone. The other 14 patients who had refractory or residual disease following a prior treatment received salvage radiotherapy...
January 10, 2017: Journal of Radiation Research
Katsuya Maruyama, Hiroshi Tsuji, Takuma Nomiya, Hiroyuki Katoh, Hitoshi Ishikawa, Tadashi Kamada, Masaru Wakatsuki, Koichiro Akakura, Jun Shimazaki, Hidefumi Aoyama, Hirohiko Tsujii
The aim of this study was to prospectively assess 5-year health-related quality of life (HRQOL) of patients treated with carbon ion radiotherapy (C-ion RT) for clinically localized prostate cancer. A total of 417 patients received carbon ion radiotherapy at a total dose of 63-66 Gray-equivalents (GyE) in 20 fractions over 5 weeks, and neoadjuvant and adjuvant androgen deprivation therapy (ADT) were administered for intermediate and high-risk patients. A HRQOL assessment was performed at five time points (immediately before the initiation of C-ion RT, immediately after, and at 12, 36 and 60 months after completion of C-ion RT) using Functional Assessment of Cancer Therapy (FACT) questionnaires...
January 1, 2017: Journal of Radiation Research
Kensuke Naganawa, Masashi Koto, Ryo Takagi, Azusa Hasegawa, Hiroaki Ikawa, Kazuo Shimozato, Tadashi Kamada, Yoshitaka Okamoto
Oral mucosal malignant melanoma (OMM) is extremely rare and has a poor prognosis. Owing to its rarity, it has not yet been possible to establish an optimal treatment modality. The objective of this study was to evaluate the long-term efficacy of carbon-ion radiotherapy (C-ion RT) for OMM. Between 1997 and 2013, 19 patients with OMM were treated with C-ion RT alone. Patient ages ranged from 44 to 84 years (median, 69 years). Nine men and 10 women were included. OMMs were restaged in accordance with the seventh edition of the tumour/node/metastasis (TNM) Staging System of the International Union Against Cancer...
December 26, 2016: Journal of Radiation Research
Satoshi Tamada, Noriko Ninomiya, Koichiro Kitamoto, Minoru Kato, Takeshi Yamasaki, Taro Iguchi, Tetsuji Ohmachi, Tatsuya Nakatani
We sought to investigate the long-term outcomes after radical prostatectomy (RP) and external-beam radiation therapy (EBRT) for the treatment of localized prostate cancer in Japanese patients. RP and radiation therapy are curative treatments for localized prostate cancer. However, there is controversy around which treatment is superior in Japanese patients. The aim of our retrospective study was to compare the long-term clinical outcomes of each treatment. We retrospectively evaluated the overall survival (OS), cancer-specific survival (CSS) and biochemical failure-free survival (BFS) for patients who had been diagnosed with localized prostate cancer and treated with RP (n = 248) or conventional 2D or 3D-CRT EBRT (n = 182) between 1995 and 2009...
December 23, 2016: Journal of Radiation Research
Tatsuya Ohno, Shin-Ei Noda, Noriyuki Okonogi, Kazutoshi Murata, Kei Shibuya, Hiroki Kiyohara, Tomoaki Tamaki, Ken Ando, Takahiro Oike, Yu Ohkubo, Masaru Wakatsuki, Jun-Ichi Saitoh, Takashi Nakano
Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated with in-room computed tomography-based brachytherapy. Eighty patients with Stage IB1-IVA cervical cancer, who had undergone treatment with combined 3D high-dose rate brachytherapy and conformal radiotherapy between October 2008 and May 2011, were retrospectively analyzed. External beam radiotherapy (50 Gy) with central shielding after 20-40 Gy was performed for each patient. Cisplatin-based chemotherapy was administered concurrently to advanced-stage patients aged ≤75 years...
December 15, 2016: Journal of Radiation Research
Yusuke Matsuya, Kaori Tsutsumi, Kohei Sasaki, Yuji Yoshii, Takaaki Kimura, Hiroyuki Date
Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basis of biological experiments and a theoretical study, we have shown that change in the amount of DNA associated with accumulation of cells in G2 enhances radiosensitivity. To demonstrate continuous irradiation with 250 kVp X-rays, we adopted a fractionated regimen of 0...
December 14, 2016: Journal of Radiation Research
Nobuyoshi Fukumitsu, Toshiyuki Okumura, Daichi Takizawa, Haruko Numajiri, Kayoko Ohnishi, Masashi Mizumoto, Teruhito Aihara, Hitoshi Ishikawa, Koji Tsuboi, Hideyuki Sakurai
Liver metastases from gastric cancer (LMGC) is a non-curable, fatal disease with a 5-year survival rate of <10%. Although various local treatments have been applied, their clinical utility has not been established. The purpose of this study was to investigate the safety and effectiveness of proton beam therapy (PBT) for the treatment of patients with LMGC. A total of nine patients (seven men, two women; aged 56-78 years) with LMGC who received PBT between 2002 and 2012 were retrospectively reviewed. Patients who had tumors confined to the liver were investigated, and patients who had extrahepatic tumors were excluded...
December 14, 2016: Journal of Radiation Research
Ryosuke Takenaka, Akihiro Haga, Hideomi Yamashita, Keiichi Nakagawa
Recently, intensity-modulated radiation therapy (IMRT) has been used for total-body irradiation (TBI). Since the planning target volume (PTV) for TBI includes the surrounding air, a dose prescription to the PTV provides high fluence to the body surface. Thus with just a small set-up error, the body might be exposed to a high-fluence beam. This study aims to assess which target volume should be prescribed the dose, such as a clinical target volume (CTV) with a margin, or a CTV that excludes the surface area of the skin...
December 14, 2016: Journal of Radiation Research
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