journal
MENU ▼
Read by QxMD icon Read
search

Journal of Lipid Research

journal
https://www.readbyqxmd.com/read/28729463/dietary-pufas-attenuate-nlrp3-inflammasome-activation-via-enhancing-macrophage-autophagy
#1
Lulu Shen, Yan Yang, Tiantong Ou, Chia-Chi C Key, Sarah H Tong, Russel C Sequeira, Jonathan M Nelson, Yan Nie, Zhan Wang, Elena Boudyguina, Swapnil V Shewale, Xuewei Zhu
Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how NLRP3 inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood. We fed Ldlr-/- mice diets containing 10% (calories) palm oil (PO) and 0.2% cholesterol, supplemented with an additional 10% of calories as PO, fish oil (FO), echium oil (EO, containing 18:4 n-3), or borage oil (BO, containing 18:3 n-6). Inflammasome activation, autophagic flux, and mitochondrial function were measured in peritoneal macrophages, blood monocytes, or liver from diet-fed mice...
July 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28720561/the-metabolism-of-lipoprotein-a-an-ever-evolving-story
#2
Gissette Reyes-Soffer, Henry N Ginsberg, Rajasekhar Ramakrishnan
NA.
July 18, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28716822/dock2-deficiency-mitigates-high-fat-diet-induced-obesity-by-reducing-adipose-tissue-inflammation-and-increasing-energy-expenditure
#3
Xia Guo, Feifei Li, Zaiyan Xu, Amelia Yin, Hang Yin, Chenxiao Li, Shi-You Chen
Obesity is the major risk factor for type 2 diabetes, cardiovascular disorders, and many other diseases. Adipose tissue inflammation is frequently associated with obesity and contributes to the morbidity and mortality. Dedicator of cytokinesis 2 (DOCK2) is involved in several inflammatory diseases, but its role in obesity remain unknown. To explore the function of DOCK2 in obesity and insulin resistance, wild-type (WT) and DOCK2 deficient (DOCK2-/-) mice were given chow or high-fat diet (HFD) for 12 weeks followed by metabolic, biochemical and histologic analyses...
July 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28710073/zinc-mediates-the-srebp-scd-axis-to-regulate-lipid-metabolism-in-caenorhabditis-elegans
#4
Jing-Jing Zhang, Jun-Jun Hao, Yu-Ru Zhang, Yan-Li Wang, Ming-Yi Li, Hui-Lai Miao, Xiao-Ju Zou, Bin Liang
Maintenance of lipid homeostasis is crucial for cells in response to lipid requirements or surplus. The SREBPs transcription factors play essential roles in regulating lipid metabolism and are associated with many metabolic diseases. However, SREBP regulation of lipid metabolism is still less understood. Here, we show that reduction of SBP-1, the only homologue of SREBPs in C. elegans, surprisingly leads to high level of zinc. On the contrary, zinc reduction by mutation of sur-7, encoding a member of the cation diffusion facilitator (CDF) family, restores the fat accumulation and fatty acid profile of sbp-1(ep79) mutant...
July 14, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28701354/pleiotropic-effects-of-apolipoprotein-c3-on-hdl-functionality-and-adipose-tissue-metabolic-activity
#5
Evangelia Zvintzou, Marie Lhomme, Stella Chasapi, Serafoula Filou, Vassilis Theodoropoulos, Eva Xepapadaki, Anatol Kontush, George Spyroulias, Constantinos C Tellis, Alexandros D Tselepis, Caterina Constantinou, Kyriakos E Kypreos
Apolipoprotein C3 (APOC3) is produced mainly by the liver and intestine and approximately half of plasma APOC3 associates with HDL. Though it was believed that APOC3 associates with HDL by simple binding to pre-existing particles, recent data support that biogenesis of APOC3-containing HDL (APOC3-HDL) requires Abca1. Moreover, APOC3-HDL contributes to plasma triglyceride homeostasis, by preventing APOC3 association with triglyceride-rich lipoproteins. Interestingly, APOC3-HDL also shows positive correlation with the morbidly obese phenotype...
July 12, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28701353/known-and-unknowns-in-the-care-of-paediatric-familial-hypercholesterolaemia
#6
Andrew C Martin, Samuel S Gidding, Albert Wiegman, Gerald F Watts
Familial hypercholesterolaemia (FH) is a common genetic disorder that causes elevated low-density lipoprotein (LDL)-cholesterol levels from birth. Untreated FH accelerates atherosclerosis and predisposes individuals to premature coronary artery disease (CAD) in adulthood. Mendelian randomization studies have demonstrated that LDL-cholesterol has both a causal and cumulative effect on the risk of CAD. This supports clinical recommendations that children with FH commence pharmacological treatment from age 8-10 years, to reduce the burden of hypercholesterolaemia...
July 12, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28698209/lipoprotein-a-the-common-likely-causal-yet-elusive-risk-factor-for-cardiovascular-disease
#7
Pia Roerbaeck-Kamstrup
No abstract text is available yet for this article.
July 11, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28698208/plasma-lipoprotein-sub-fraction-concentrations-are-associated-with-lipid-metabolism-and-age-related-macular-degeneration
#8
Chui Ming Gemmy Cheung, Alfred Gan, Qiao Fan, Miao Ling Chee, Rajendra S Apte, Chiea Chuen Khor, Ian Yeo, Ranjana Mathur, Ching-Yu Cheng, Tien Yin Wong, E Shyong Tai
Disturbance in lipid metabolism has been suggested as a major pathogenic factor for age-related macular degeneration (AMD). Conventional lipid measures have been inconsistently associated with AMD. Other factors which can alter lipid metabolism include lipoprotein phenotype and genetic mutations. We performed a case-control study to examine the association between lipoprotein profile and neovascular AMD (nAMD), and whether the cholesterylester transfer protein CETP D442G mutation modulates these associations...
July 11, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28694298/compound-specific-isotope-analysis-resolves-the-dietary-origin-of-docosahexaenoic-acid-dha-in-the-mouse-brain
#9
R J Scott Lacombe, Vanessa Giuliano, Stefanie M Colombo, Michael T Arts, Richard P Bazinet
Docosahexaenoic acid (DHA, 22:6n-3) may be derived from two dietary sources, preformed dietary DHA or through synthesis from α-linolenic acid (ALA, 18:3n-3). However, conventional methods cannot distinguish between DHA derived from either source without the use of costly labelled tracers. In the present study, we demonstrate the proof-of-concept that compound specific isotope analysis (CSIA) by gas chromatography-isotope ratio mass spectrometry (GC-IRMS) can differentiate between sources of brain DHA based on differences in natural (13)C enrichment...
July 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28694297/sensitive-and-selective-quantification-of-free-and-total-malondialdehyde-in-plasma-using-uhplc-hrms
#10
Rute Mendonça, Ophélie Gning, Claudia Di Cesaré, Laurence Lachat, Nigel C Bennett, Fabrice Helfenstein, Gaétan Glauser
Quantification of malondialdehyde (MDA) as a marker of lipid peroxidation is relevant for many research fields. We describe a new sensitive and selective method to measure free and total plasmatic MDA, using derivatization with 2,4-dinitrophenylhydrazine (DNPH) and ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS). Free and total MDA were extracted from minute sample amounts (10 μL) using acidic precipitation and alkaline hydrolysis followed by acidic precipitation, respectively...
July 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28694296/apolipoprotein-c-iii-inhibits-triglyceride-hydrolysis-by-gpihbp1-bound-lpl
#11
Mikael Larsson, Christopher M Allan, Rachel S Jung, Patrick J Heizer, Anne P Beigneux, Stephen G Young, Loren G Fong
Apolipoprotein C-III (apoC-III) is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting lipoprotein lipase (LPL), but that view is based largely on studies of free LPL. We now recognize that intravascular LPL is neither free nor loosely bound but instead is tightly bound to GPIHBP1 on endothelial cells. Here, we revisited the effects of apoC-III on LPL, focusing on apoC-III's capacity to affect the activity of GPIHBP1-bound LPL. We found that TRLs from APOC3 transgenic mice bound normally to GPIHBP1-bound LPL on cultured cells in vitro and to heart capillaries in vivo...
July 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28679588/adipocyte-mtorc1-deficiency-promotes-adipose-tissue-inflammation-and-nlrp3-inflammasome-activation-via-oxidative-stress-and-de-novo-ceramide-synthesis
#12
Patricia Chimin, Maynara L Andrade, Thiago Belchior, Vivian A Paschoal, Juliana Magdalon, Alex S Yamashita, Erique Castro, Angela Castoldi, Adriano B Chaves-Filho, Marcos Y Yoshinaga, Sayuri Miyamoto, Niels O Camara, William T Festuccia
Mechanistic Target of Rapamycin complex 1 (mTORC1) activity is increased in adipose tissue of obese, insulin resistant mice, but its role in the regulation of tissue inflammation is unknown. We investigated herein the effects of adipocyte mTORC1 deficiency on adipose tissue inflammation and glucose homeostasis. For this, mice with adipocyte raptor deletion and controls fed a chow or a high-fat diet were evaluated for body mass, adiposity, glucose homeostasis and adipose tissue inflammation. Despite reducing adiposity, adipocyte mTORC1 deficiency promoted hepatic steatosis, insulin resistance and adipose tissue inflammation (increased infiltration of macrophages, neutrophils and B lymphocytes, crown-like structure density, TNF-α, IL-6 and MCP1 expression, IL-1β protein content, lipid peroxidation and de novo ceramide synthesis)...
July 5, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28667077/dietary-linoleic-acid-and-sex-effects-on-oxylipin-profiles-in-rat-kidney-liver-and-serum-differ-from-their-effects-on-polyunsaturated-fatty-acids
#13
Shan Leng, Tanja Winter, Harold M Aukema
A vast literature on fatty acids in mammals exists, but comparable compositional data on oxylipins is lacking. Weanling Sprague-Dawley rats were therefore provided control diets or diets with higher linoleic acid (LA), or with higher LA and α-linolenic acid (LA+ALA) for six weeks. Kidneys, livers and serum were analyzed for oxylipins and fatty acids. The proportion of tissue oxylipins derived from LA was greater than the relative proportion of LA itself, while arachidonic acid (AA) oxylipins were overrepresented in serum...
June 30, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28663239/secretory-phospholipase-a2-group-iia-pla2g2a-modulates-insulin-sensitivity-and-metabolism
#14
Michael S Kuefner, Kevin Pham, Jeanna R Redd, Erin J Stephenson, Innocence Harvey, Xiong Deng, Dave Bridges, Eric Boilard, Marshall B Elam, Edwards A Park
Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases which have been implicated in inflammation, atherogenesis and antibacterial actions. Here, we evaluated the role of PLA2G2A in the metabolic response to a high fat diet. C57BL/6 mice do not express PLA2g2a due to a frameshift mutation. We fed C57BL/6 mice expressing the human PLA2G2A gene (IIA+ mice) a fat diet and assessed the physiologic response. After 10 weeks on the high fat diet, the C57BL/6 mice were obese, but the IIA+ mice did not gain weight or accumulate lipid...
June 29, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28655726/high-density-lipoproteins-and-type-2-inflammatory-biomarkers-are-negatively-correlated-in-atopic-asthmatics
#15
Amisha V Barochia, Elizabeth M Gordon, Maryann Kaler, Rosemarie A Cuento, Patricia Theard, Debbie M Figueroa, Xianglan Yao, Nargues A Weir, Maureen L Sampson, Mario Stylianou, David F Choy, Cecile T J Holweg, Alan T Remaley, Stewart J Levine
Blood eosinophil counts and serum periostin levels are biomarkers of type 2 inflammation. Although serum levels of HDL (high-density lipoprotein) and apolipoprotein A-I have been associated with less severe airflow obstruction in asthma, it is not known whether serum lipids or lipoprotein particles are correlated with type 2 inflammation in asthmatics. Here, we assessed whether serum lipids and lipoproteins correlated with blood eosinophil counts or serum periostin levels in 165 atopic asthmatics, and 163 non-asthmatic subjects with and without atopy...
June 27, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28655725/chemical-chaperone-4-phenyl-butyric-acid-4pba-reduces-hepatocellular-lipid-accumulation-and-lipotoxicity-through-induction-of-autophagy
#16
Ashraf U Nissar, Love Sharma, Malik A Mudasir, Lone A Nazir, Sheikh A Umar, Parduman R Sharma, Ram A Vishwakarma, Sheikh A Tasduq
Defective autophagy has been linked to lipotoxicity in several cellular models. We aimed to investigate autophagy in lipid stimulated hepatoma (Huh7) cells and tested whether 4-Phenyl butyric acid (4PBA), a chemical chaperone, has a beneficial role in hepatic fat accumulation and lipotoxicity. We report that long-term (24h) exposure of hepatocytes to palmitate block autophagic flux that leads to lipid accumulation and cell death. Western blotting analysis showed increased accumulation of SQSTM1/P62, decreased expression of Beclin1 and Atg7 in palmitate-treated cells...
June 27, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28634192/a-new-enzyme-linked-immunosorbent-assay-system-for-human-serum-hepatic-triglyceride-lipase
#17
Kazuya Miyashita, Katsuyuki Nakajima, Isamu Fukamachi, Yuji Muraba, Takafumi Koga, Yohnosuke Shimomura, Tetsuyo Machida, Masami Murakami, Junji Kobayashi
There is no previously established method for measuring human hepatic triglyceride lipase (HTGL) concentration in serum. In this study, we developed new monoclonal antibodies (MoAb mouse 9A1, MoAb rat 141A1) that react with both HTGL in serum and in post-heparin plasma (PHP) and established a novel enzyme-linked immunosorbent assay (ELISA) system for measuring serum HTGL as well as PHP-HTGL concentrations. To confirm the specificity of MoAb, we performed an immunoprecipitation -immunoblotting analysis. Both MoAb mouse 9A1and MoAb rat 141 A1 were able to immunoprecipitate not only recombinant HTGL and PHP-HTGL but also serum HTGL, demonstrating that HTGL exists in serum obtained without heparin injection...
June 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28634191/cd36-knockout-mice-are-protected-against-lithogenic-diet-induced-gallstones
#18
Yan Xie, Vincenza Cifarelli, Terri Pietka, Elizabeth P Newberry, Susan M Kennedy, Amin Khalifeh-Soltani, Robin Clugston, Kamran Atabai, Nada A Abumrad, Nicholas O Davidson
The scavenger receptor and multiligand transporter CD36 functions to promote cellular free fatty acid uptake and regulates aspects of both hepatic and intestinal cholesterol metabolism. However, the role of CD36 in regulating canalicular and biliary cholesterol transport and secretion is unknown. Here we show that germline Cd36 knockout mice are protected against lithogenic diet (LD) induced gallstones compared to congenic (C57BL6/J) controls. Cd36 knockout mice crossed into congenic L-Fabp knockout mice (DKO mice) demonstrated protection against LD induced gallstones, reversing the susceptibility phenotype observed in L-Fabp knockout mice...
June 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28630261/anti-inflammatory-liaisons-t-regulatory-cells-and-hdl-apoa-i
#19
Mary G Sorci-Thomas, Michael J Thomas
No abstract text is available yet for this article.
June 19, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28630260/cholesterol-auxotrophy-and-intolerance-to-ezetimibe-in-mice-with-srebp-2-deficiency-in-the-intestine
#20
Shunxing Rong, Jeffrey McDonald, Luke Engelking
Sterol regulatory element-binding protein-2 (SREBP-2) activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in intestine, we generated a mouse model (Vil-BP2(-/-) ) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of Vil-BP2(-/-) mice had reduced expression of genes required for sterol synthesis, in vivo sterol synthesis rates, and epithelial cholesterol contents. On a cholesterol-free diet, they displayed chronic enteropathy with histological abnormalities of both villi and crypts, growth restriction, and reduced survival that was prevented by supplementation of cholesterol in the diet...
June 19, 2017: Journal of Lipid Research
journal
journal
23973
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"