journal
MENU ▼
Read by QxMD icon Read
search

Journal of Clinical Pathology

journal
https://www.readbyqxmd.com/read/28924059/pygopus2-expression-in-prostatic-adenocarcinoma-is-a-potential-risk-stratification-marker-for-psa-progression-following-radical-prostatectomy
#1
Kenneth R Kao, Paul Popadiuk, John Thoms, Satoko Aoki, Shahgul Anwar, Emily Fitzgerald, Phillip Andrews, Kim Voisey, Luis Gai, Satya Challa, Zhijian He, Paola Gonzales-Aguirre, Andrea Simmonds, Catherine Popadiuk
AIMS: Prostate cancer (PrCa) is the most frequently diagnosed non-cutaneous cancer in men. Without clear pathological indicators of disease trajectory at diagnosis, management of PrCa is challenging, given its wide-ranging manifestation from indolent to highly aggressive disease. This study examines the role in PrCa of the Pygopus (PYGO)2 chromatin effector protein as a risk stratification marker in PrCa. METHODS: RNA expression was performed in PrCa cell lines using Northern and RT-PCR analyses...
September 18, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28916596/cutaneous-angiosarcoma-a-current-update
#2
REVIEW
Elina Shustef, Viktoryia Kazlouskaya, Victor G Prieto, Doina Ivan, Phyu P Aung
Cutaneous angiosarcoma (cAS) is a rare malignant neoplasm with variable clinical presentation. Although a distinct vascular tumour, cAS shares many overlapping histopathological features with other vasoformative and epithelioid tumours or 'mimickers'. cAS shows aggressive behaviour and carries a grave prognosis, thus early diagnosis is of paramount importance to achieve the best possible outcomes. Recently, several genetic studies were conducted leading to the identification of novel molecular targets in the treatment of cAS...
September 15, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28916595/normative-data-for-flow-cytometry-immunophenotyping-of-benign-lymph-nodes-sampled-by-surgical-biopsy
#3
Gregory David Scott, Susan K Atwater, Dita A Gratzinger
AIMS: To create clinically relevant normative flow cytometry data for understudied benign lymph nodes and characterise outliers. METHODS: Clinical, histological and flow cytometry data were collected and distributions summarised for 380 benign lymph node excisional biopsies. Outliers for kappa:lambda light chain ratio, CD10:CD19 coexpression, CD5:CD19 coexpression, CD4:CD8 ratios and CD7 loss were summarised for histological pattern, concomitant diseases and follow-up course...
September 15, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28903996/crouching-tiger-hidden-dragon
#4
Daniel Hopkins, Murali Varma
No abstract text is available yet for this article.
September 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28903995/ros1-1
#5
REVIEW
Prodipto Pal, Zanobia Khan
ROS1 is a receptor tyrosine kinase that has recently been shown to undergo gene rearrangements in~1%-2% of non-small cell lung carcinoma (NSCLC) and in a variety of other tumours including cholangiocarcinoma, gastric carcinoma, colorectal carcinoma and in spitzoid neoplasms, glioblastoma and inflammatory myofibroblastic tumours. The ROS1 gene fusion undergoes constitutive activation, regulates cellular proliferation and is implicated in carcinogenesis. ROS1 fusions can be detected by fluorescence in situ hybridisation, real-time PCR, sequencing-based techniques and immunohistochemistry-based methods in clinical laboratories...
September 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28903994/the-level-of-heparin-induced-antibodies-in-correlation-with-the-result-of-the-flow-cytometric-functional-assay-in-the-patients-with-suspected-hit
#6
Elvira Maličev, Marjeta Maček Kvanka, Polona Klemenc, Primož Rožman
Heparin can induce the formation of antibodies against a heparin complex with a platelet factor 4 (PF4), leading to platelet activation and the development of heparin-induced thrombocytopaenia (HIT). Because screening ELISA does not discriminate between platelet activating and non-activating anti-heparin/PF4 antibodies, each positive result is confirmed by an additional functional assay. We analysed 1004 sera of patients with suspected HIT. Optical density (OD) values of ELISA-positive results were correlated with the risk for a positive result with our functional flow cytometric assay...
September 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28899980/standardisation-of-practice-for-canadian-pathologists-assistants
#7
EDITORIAL
Martin Grealish, Alan Wolff, Jodi Eastwood, Danielle Lee
No abstract text is available yet for this article.
September 12, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28899979/clinical-performance-evaluation-of-the-idylla-nras-braf-mutation-test-on-retrospectively-collected-formalin-fixed-paraffin-embedded-colorectal-cancer-tissue
#8
Louise Johnston, Michael Power, Philip Sloan, Anna Long, Angela Silmon, Ben Chaffey, Andrea Jane Lisgo, Liam Little, Ellen Vercauteren, Torben Steiniche, Tine Meyer, John Simpson
AIMS: Understanding the molecular mechanisms of underlying disease has led to a movement away from the one-drug-fits-all paradigm towards treatment tailored to the genetic profile of the patient. The Biocartis Idylla platform is a novel fully automated, real-time PCR-based in vitro diagnostic system. The Idylla NRAS-BRAF mutation test has been developed for the qualitative detection of mutations in NRAS and BRAF oncogenes, facilitating genetic profiling of patients with cancer. The aim of this study was to carry out a formal clinical performance evaluation...
September 12, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28893862/molecular-profile-of-nasopharyngeal-carcinoma-analysing-tumour-suppressor-gene-promoter-hypermethylation-by-multiplex-ligation-dependent-probe-amplification
#9
Marc Ooft, Jolique van Ipenburg, Rob van Loo, Rick de Jong, Cathy Moelans, Weibel Braunius, Remco de Bree, Paul van Diest, Senada Koljenović, Rob Baatenburg de Jong, Jose Hardillo, Stefan Willems
AIMS: To assess differences in methylation profiles, and thus pathogenesis, between Epstein-Barr virus (EBV)-positive and negative nasopharyngeal carcinomas (NPCs). Also, promoter hypermethylation is a common phenomenon in early carcinogenesis to inactivate tumour suppressor genes. Since epigenetic changes are reversible, the therapeutic application of methylation inhibitors could provide treatment options. METHODS: We evaluated promoter hypermethylation profiles of 22 common tumour suppressor genes in 108 NPCs using methylation-specific multiplex ligation-dependent probe amplification...
September 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28893861/adrenal-venous-sampling-for-primary-aldosteronism-laboratory-medicine-best-practice
#10
Gregory Kline, Daniel T Holmes
Primary aldosteronism (PA) is the most common form of secondary hypertension and is critical to identify because when caused by an aldosterone-producing adenoma (APA) or another unilateral form, it is potentially curable, and even when caused by bilateral disease, antihypertensives more specific to PA treatment can be employed (ie, aldosterone antagonists). Identification of unilateral forms is not generally accomplished with imaging because APAs may be small and elude detection, and coincidental identification of a non-functioning incidentaloma contralateral to an APA may lead to removal of an incorrect gland...
September 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28877960/rt-pcr-for-the-diagnosis-of-clostridium-difficile-infection-the-final-answer-has-yet-to-come
#11
LETTER
Valeria Visconti, Grazia Brunetti, Alessandra Giordano, Giammarco Raponi
No abstract text is available yet for this article.
September 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28877959/prognostic-role-of-tumour-associated-macrophages-and-regulatory-t-cells-in-ebv-positive-and-ebv-negative-nasopharyngeal-carcinoma
#12
Marc L Ooft, Jolique A van Ipenburg, Maxime E Sanders, Mariette Kranendonk, Ingrid Hofland, Remco de Bree, Senada Koljenović, Stefan M Willems
AIMS: Tumour-associated macrophages (TAMs) and regulatory T cells (Tregs) form a special niche supporting tumour progression, and both correlate with worse survival in head and neck cancers. However, the prognostic role of TAM and Tregs in nasopharyngeal carcinoma (NPC) is still unknown. Therefore, we determined differences in TAMs and Tregs in different NPC subtypes, and their prognostic significance. METHODS: Tissue of 91 NPCs was assessed for TAMs and Tregs by determination of CD68, CD163, CD206 and FOXP3 expression in the tumour microenvironment...
September 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28870889/mir-194-as-predictive-biomarker-of-responsiveness-to-neoadjuvant-chemoradiotherapy-in-patients-with-locally-advanced-rectal-adenocarcinoma
#13
Edoardo D'Angelo, Carlo Zanon, Francesca Sensi, Maura Digito, Massimo Rugge, Matteo Fassan, Marco Scarpa, Salvatore Pucciarelli, Donato Nitti, Marco Agostini
AIMS: Curative surgery remains the primary form of treatment for locally advanced rectal cancer (LARC). Recent data support the use of preoperative chemoradiotherapy (pCRT) to improve the prognosis of LARC with a significant reduction of local relapse and an increase of overall survival. Unfortunately, only 20% of the patients with LARC present complete pathological response after pCRT, whereas in 20%-40%, the response is poor or absent. METHODS: We investigated the expression level of miR-194 in n=38 patients with LARC using our public microRNA (miRNA) expression dataset...
September 4, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28844038/unrestricted-faecal-calprotectin-testing-performs-poorly-in-the-diagnosis-of-inflammatory-bowel-disease-in-patients-in-primary-care
#14
Samantha Conroy, Melissa F Hale, Simon S Cross, Kirsty Swallow, Reena H Sidhu, Ravishankar Sargur, Alan J Lobo
BACKGROUND: Faecal calprotectin (FC) measurement distinguishes patients with inflammatory bowel disease (IBD) from those with irritable bowel syndrome but evidence of its performance in primary care is limited. AIMS: To assess the yield of IBD from FC testing in primary care. METHODS: Retrospective review of hospital records to assess the outcome following FC testing in primary care. Investigations for all patients undergoing FC testing in a single laboratory for 6 months from 1 October 2013 to 28 February 2014 were reviewed...
August 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28844037/targeting-the-anterior-superior-iliac-spine-yields-significantly-longer-bone-marrow-cores
#15
Louis Reed, Shirin Attarian, Gopichand Pendurti, Aditi P Singh, Anjali Budhathoki, Simon Abi-Aad, Urvi A Shah, Salem Kim, Kimo Bachiashvili, Jee Young Moon, Mimi Kim, Tarek Elrafei, Karenza Alexis, Marianna Strakhan, Weijuan Li, Ellen Friedman
Pathologists and haematologists generally agree that the length of the biopsy core is a good surrogate for the diagnostic quality of the bone marrow. Previous studies suggested that the angulation of the biopsy needle from the posterior superior iliac spine (PSIS) could influence the length of the biopsy cores, targeting the anterior superior iliac spine (ASIS) from the PSIS would yield longer specimens than the traditional angulation technique (TAT), where the biopsy needle is directed straight in, perpendicular to the plane of the back...
August 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28830908/preservation-of-bacterial-dna-in-10-year-old-guaiac-fobt-cards-and-fit-tubes
#16
LETTER
Matheus Couto Furtado Albuquerque, Yasmijn van Herwaarden, Guus A M Kortman, Bas E Dutilh, Tanya Bisseling, Annemarie Boleij
No abstract text is available yet for this article.
August 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28824010/innovative-haematological-parameters-for-early-diagnosis-of-sepsis-in-adult-patients-admitted-in-intensive-care-unit
#17
Sabrina Buoro, Barbara Manenti, Michela Seghezzi, Paola Dominoni, Tiziano Barbui, Arianna Ghirardi, Alessandra Carobbio, Gianmariano Marchesi, Ivano Riva, Alessandra Nasi, Cosimo Ottomano, Giuseppe Lippi
AIMS: This study was aimed to investigate the role of erythrocyte, platelet and reticulocyte (RET) parameters, measured by new haematological analyser Sysmex XN and C reactive protein (CRP), for early diagnosis of sepsis during intensive care unit (ICU) stay. METHODS: The study population consisted of 62 ICU patients, 21 of whom developed sepsis during ICU stay and 41 who did not. The performance for early diagnosing of sepsis was calculated as area under the curve (AUC) of receiver operating characteristics curves analysis...
August 20, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28822961/use-of-key-performance-indicators-in-histological-dissection
#18
Matthew Griffiths, Rachel Gillibrand
AIMS: Reports into standards in the National Health Service and quality in pathology have focused on the way we work in pathology and how to provide assurance that this is of a high standard. There are a number of external quality assurance schemes covering pathology and histopathology specifically; however, there is no scheme covering the process of histological surgical dissection. This is an area undergoing development, emerging from the sole preserve of medically qualified pathologists to a field populated by a number of highly trained biomedical scientists, but remains without any formal quality assurance...
August 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821583/role-of-leucocytes-cell-population-data-in-the-early-detection-of-sepsis
#19
Eloísa Urrechaga, Oihane Bóveda, Urko Aguirre
AIMS: The cell population data (CPD) parameters reported by XN analyser (Sysmex, Kobe, Japan) reflect the size and internal structure of leucocytes. We aimed to assess the clinical utility of these parameters as biomarkers for the early diagnosis of sepsis. METHODS: The study group (G1) included 586 controls (no quantitative or morphological alterations in the complete blood count) and 137 patients diagnosed with sepsis. The reliability of the model was evaluated using a validation group (G2) of 212 controls and 60 patients with sepsis...
August 18, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821582/identification-of-%C3%AE-enolase-as-a-prognostic-and-diagnostic-precancer-biomarker-in-oral-submucous-fibrosis
#20
Swarnendu Bag, Debabrata Dutta, Amrita Chaudhary, Bidhan Chandra Sing, Mousumi Pal, Ajoy Kumar Ray, Rita Banerjee, Ranjan Rashmi Paul, Amit Basak, Amit Kumar Das, Jyotirmoy Chatterjee
AIMS: Diagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF. METHODS: The high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistry (IHC), Western blot (WB) and real-time PCR (RT-PCR) analysis are considered for such biomarker identification and multilevel validations...
August 18, 2017: Journal of Clinical Pathology
journal
journal
23972
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"