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Journal of Clinical Pathology

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https://www.readbyqxmd.com/read/29146886/cutaneous-lymphoma
#1
Alia Gupta, Uma Sundram
No abstract text is available yet for this article.
November 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29146885/mammary-phyllodes-tumour-a-15-year-multicentre-clinical-review
#2
Michael Co, Clement Chen, Julia Y Tsang, Gary Tse, Ava Kwong
AIMS: Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis. METHODS: A 15-year retrospective review from a multicentre database in Hong Kong was performed. RESULTS: Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12-86 years)...
November 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29146884/computer-graphics-for-the-microscopist
#3
LETTER
Jhonel Palomino, Anders Hånell
No abstract text is available yet for this article.
November 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29138285/expression-and-prognostic-significance-of-human-epidermal-growth-factor-receptors-1-2-and-3-in-oesophageal-and-gastric-adenocarcinomas-preneoadjuvant-and-postneoadjuvant-treatment
#4
Charlotta Hedner, David Borg, Björn Nodin, Emelie Karnevi, Karin Jirström, Jakob Eberhard
AIMS: Neoadjuvant treatment has now become the standard of care for oesophageal and gastric cancer. The aim of this study was to investigate the influence of neoadjuvant therapy on the expression of human epidermal growth factor receptor 1 (HER1/EGFR), HER2 and HER3, in oesophageal and gastric adenocarcinoma. METHODS: Immunohistochemical expression of EGFR, HER2 and HER3 was examined and compared in pretreatment biopsies, post-treatment surgical resection specimens and metastases in a retrospective cohort of 166 patients with adenocarcinoma of the oesophagus or stomach...
November 14, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29138284/rapid-diagnosis-of-pulmonary-tuberculosis-and-detection-of-drug-resistance-by-combined-simultaneous-amplification-testing-and-reverse-dot-blot
#5
Yiwen Chen, Lahong Zhang, Liquan Hong, Xian Luo, Juping Chen, Leiming Tang, Jiahuan Chen, Xia Liu, Zhaojun Chen
AIMS: Making a correct and rapid diagnosis is essential for managing pulmonary tuberculosis (PTB), particularly multidrug-resistant tuberculosis. We aimed to evaluate the efficacy of the combination of simultaneous amplification testing (SAT) and reverse dot blot (RDB) for the rapid detection of Mycobacterium tuberculosis (MTB) and drug-resistant mutants in respiratory samples. METHODS: 225 suspected PTB and 32 non-TB pulmonary disease samples were collected. All sputum samples were sent for acid-fast bacilli smear, SAT, culture and drug susceptibility testing (DST) by the BACTEC(TM) MGIT(TM) 960 system...
November 14, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29138283/frequency-of-and-reasons-for-paroxysmal-nocturnal-haemoglobinuria-screening-in-patients-with-unexplained-anaemia
#6
James T England, Bakul Dalal, Heather A Leitch
Referral to hematology for anemia is common. In paroxysmal nocturnal hemoglobinuria (PNH), cells deficient in the glycosylphosphatidyl inositol (GPI) anchor are lysed by complement. Eculizumab improves overall survival and quality of life while reducing hemolysis, transfusion requirements, and thrombosis. We evaluated the frequency of screening for PNH in patients with unexplained anemia. Key clinical features, laboratory data, and investigations were recorded for patients referred for anemia since 2010, without a specific cause found...
November 14, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29127142/can-reference-images-improve-interobserver-agreement-in-reporting-liver-fibrosis
#7
Alyn L German, Kenneth Fleming, Philip Kaye, Susan Davies, Robert Goldin, Stefan G Hubscher, Dina Tiniakos, Angus McGregor, Judith I Wyatt
Staging of fibrosis in medical liver biopsies has inherent interobserver variability. There are a number of disease-specific scoring systems available. While recognising the importance of these scoring systems, there is scope to consider how concordance amongst histopathologists could be improved using a generic fibrosis staging system.Using virtual slides, we approached both specialist liver histopathologists and general histopathologists from the UK to assess the degree of fibrosis against a proposed four-tiered reporting system...
November 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29127141/copper-deposition-in-focal-nodular-hyperplasia-and-inflammatory-hepatocellular-adenoma
#8
Vishal S Chandan, Sejal S Shah, Taofic Mounajjed, Michael S Torbenson, Tsung-Teh Wu
AIMS: To examine copper deposition in focal nodular hyperplasia (FNH) and inflammatory hepatocellular adenoma (IHA) and to determine if it can play a role in their differentiation. METHODS: 28 FNHs and 19 IHAs from surgical resections showing typical morphological and immunohistochemical features were stained with rhodanine to evaluate for copper deposition. Histological features such as nodularity, fibrous bands, ductular proliferation, steatosis, ballooned hepatocytes and lymphocytic inflammation were also scored...
November 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29127140/cancer-genes-mutation-profiling-in-calcifying-epithelial-odontogenic-tumour
#9
Sílvia Ferreira de Sousa, Marina Gonçalves Diniz, Josiane Alves França, Thaís Dos Santos Fontes Pereira, Rennan Garcias Moreira, Jean Nunes Dos Santos, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
AIMS: To identify calcifying epithelial odontogenic tumour (CEOT) mutations in oncogenes and tumour suppressor genes. METHODS: A panel of 50 genes commonly mutated in cancer was sequenced in CEOT by next-generation sequencing. Sanger sequencing was used to cover the region of the frameshift deletion identified in one sample. RESULTS: Missense single nucleotide variants (SNVs) with minor allele frequency (MAF) <1% were detected in PTEN, MET and JAK3...
November 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29113995/time-for-change-a-new-training-programme-for-morpho-molecular-pathologists
#10
REVIEW
David A Moore, Caroline A Young, Hayley T Morris, Karin A Oien, Jessica L Lee, J Louise Jones, Manuel Salto-Tellez
The evolution of cellular pathology as a specialty has always been driven by technological developments and the clinical relevance of incorporating novel investigations into diagnostic practice. In recent years, the molecular characterisation of cancer has become of crucial relevance in patient treatment both for predictive testing and subclassification of certain tumours. Much of this has become possible due to the availability of next-generation sequencing technologies and the whole-genome sequencing of tumours is now being rolled out into clinical practice in England via the 100 000 Genome Project...
November 7, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29097601/sporadic-granular-cell-tumours-lack-recurrent-mutations-in-ptpn11-pten-and-other-cancer-related-genes
#11
LETTER
Josiane Alves França, Sílvia Ferreira de Sousa, Rennan Garcias Moreira, Vanessa Fátima Bernardes, Letícia Martins Guimarães, Jean Nunes Santos, Marina Gonçalves Diniz, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
No abstract text is available yet for this article.
November 2, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29097600/pd-l1
#12
REVIEW
Anthousa Kythreotou, Abdul Siddique, Francesco A Mauri, Mark Bower, David J Pinato
Programmed death ligand 1 (PD-L1) is the principal ligand of programmed death 1 (PD-1), a coinhibitory receptor that can be constitutively expressed or induced in myeloid, lymphoid, normal epithelial cells and in cancer. Under physiological conditions, the PD-1/PD-L1 interaction is essential in the development of immune tolerance preventing excessive immune cell activity that can lead to tissue destruction and autoimmunity. PD-L1 expression is an immune evasion mechanism exploited by various malignancies and is generally associated with poorer prognosis...
November 2, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29097599/brains-with-sporadic-creutzfeldt-jakob-disease-and-copathology-showed-a-prolonged-end-stage-of-disease
#13
Aitzol Miguelez-Rodriguez, Jorge Santos-Juanes, Ikerne Vicente-Etxenausia, Katty Perez de Heredia-Goñi, Beatriz Garcia, Luis M Quiros, Laura Lorente-Gea, Isabel Guerra-Merino, Jose J Aguirre, Ivan Fernandez-Vega
AIMS: To investigate the expression of major proteins related to primary neurodegenerative diseases and their prognostic significance in brains with Creutzfeldt-Jakob disease (CJD). MATERIALS AND METHODS: Thirty consecutive cases of confirmed CJD during the period 2010-2015 at Basque Brain bank were retrospectively reviewed. Moreover, major neurodegenerative-associated proteins (phosphorylated Tau, 4R tau, 3R tau, alpha-synuclein, TDP43, amyloid beta) were tested...
November 2, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29092999/recurrent-gastrointestinal-bleeding-in-a-patient-with-igm-paraproteinaemia
#14
Sanjay de Mel, Muhammad Bilal Abid, Kok-Siong Poon, Sau-Yoke Ng, Li-Mei Poon, Shi Wang
No abstract text is available yet for this article.
November 1, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29074611/zinc-finger-an1-type-containing-4-is-a-novel-marker-for-predicting-metastasis-and-poor-prognosis-in-oral-squamous-cell-carcinoma
#15
Miyako Kurihara-Shimomura, Tomonori Sasahira, Hiroshi Nakamura, Chie Nakashima, Hiroki Kuniyasu, Tadaaki Kirita
AIMS: Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth most common cancer worldwide and has a high potential for locoregional invasion and nodal metastasis. Therefore, discovery of a useful molecular biomarker capable of predicting tumour progression and metastasis of OSCC is crucial. We have previously reported zinc finger AN1-type containing 4 (ZFAND4) as one of the most upregulated genes in recurrent OSCC using a cDNA microarray analysis. Although ZFAND4 has been shown to promote cell proliferation of gastric cancer, its expression and clinicopathological roles in OSCC remain unclear...
October 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29070651/gene-of-the-month-sdh
#16
REVIEW
Alessandro Pietro Aldera, Dhirendra Govender
Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain. Germline mutations in SDHA are associated with Leigh syndrome. Mutations in SDHB, SDHC and SDHD are found in an increasing number of neoplasms, most notably paragangliomas and wild-type gastrointestinal stromal tumours. SDH deficiency in these tumours has important prognostic implications, and also provides a novel target for molecular therapy...
October 25, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29055897/t-cell-clonality-assessment-past-present-and-future
#17
REVIEW
Etienne Mahe, Tevor Pugh, Suzanne Kamel-Reid
T cell clonality testing has important clinical and research value, providing a specific and reproducible assessment of clonal diversity in T cell proliferations. Here we review the conceptual foundations of T cell clonality assays, including T cell ontogeny and T cell receptor structure and function; we also provide an introduction to T cell receptor genomics and the concept of the T cell clonotype. This is followed by a review of historical and current methods by which T cell clonality may be assayed, including current assay limitations...
October 21, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29055896/sifd-as-a-novel-cause-of-severe-fetal-hydrops-and-neonatal-anaemia-with-iron-loading-and-marked-extramedullary-haemopoiesis
#18
Chris Barton, Sabiha Kausar, Deborah Kerr, Stefania Bitetti, Rob Wynn
SIFD describes a heritable, syndromic condition characterised principally by sideroblastic anaemia (SA) with immunodeficiency, fevers and developmental delay, arising in mutations within the TRNT1 gene. Other clinical manifestations of SIFD include cardiomyopathy, seizures, sensorineural hearing loss, renal dysfunction, metabolic abnormalities, hepatosplenomegaly and retinitis pigmentosa.Presentation of SIFD is variable but typically in early childhood with SA or with fever. In this report, we extend the described SIFD phenotype...
October 21, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29051317/expression-and-prognostic-significance-of-ect2-in-invasive-breast-cancer
#19
Hong-Kun Wang, Jian-Fang Liang, Hui-Xia Zheng, Hong Xiao
AIMS: To investigate the expression of epithelial cell transforming sequence 2 (ECT2) in invasive breast cancer and its prognostic significance. METHODS: ECT2 immunohistochemical detection was performed in 165 breast cancer specimens and 100 normal control tissues. Univariable and multivariable Cox proportional hazards regression model analysis was used to confirm independent prognostic factors. The PHREG procedure linear hypotheses testing method was used to analyse survival data...
October 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29021147/atypical-haematological-presentation-in-a-case-of-polycythaemia-vera-with-a-new-variant-mutation-detected-in-exon-12-c-1605g-t-p-met535ile
#20
Amélia Soraia Andrade Pita, Ana Paula da Silva Azevedo, Alice Reichert, Cândido José Pimenta da Silva, Vanessa Henriques, Diana Sousa Mendes, Ana Maria Batalha Reis, Rita Cerqueira, Fátima Torres, João Faro Viana
One of the major genetic insights into the pathogenesis of polycythaemia vera included the identification of the somatic point gain-of-function mutations in Janus kinase 2 gene-first JAK2V617F on exon 14, present in 95%-97% of the cases, and later on exon 12. In the literature, we can find some reported studies where different exon 12 mutations are identified. Unlike patients with JAK2V617F mutation in exon 14, the mutation at exon 12 is not usually associated with an increase in the three haematopoietic series (erythrocytosis, leucocytosis and thrombocytosis)...
October 11, 2017: Journal of Clinical Pathology
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