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Journal of Clinical Pathology

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https://www.readbyqxmd.com/read/28645945/how-can-we-ensure-that-the-coroner-s-autopsy-is-not-an-invasion-of-human-rights
#1
Stephen Leadbeatter, Ryk James
BACKGROUND: Despite public inquiries, and some changes to legislation following high-profile multiple homicides that were not detected by autopsy, coroners continue to rely largely on the autopsy. Regardless of the extent of quality failings and excess deaths at some hospitals, not detected through the coroner system, the autopsy is scarcely used by hospitals to monitor standards and educate. OBJECTIVE: To explore when a compulsory medicolegal autopsy should, and should not, be used...
June 23, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28630050/effectiveness-of-computer-aided-diagnosis-cadx-of-breast-pathology-using-immunohistochemistry-results-of-core-needle-biopsy-samples-for-synaptophysin-oestrogen-receptor-and-ck14-p63-for-classification-of-epithelial-proliferative-lesions-of-the-breast
#2
Ichiro Maeda, Manabu Kubota, Jiro Ohta, Kimika Shinno, Shinya Tajima, Yasushi Ariizumi, Masatomo Doi, Yoshiyasu Oana, Yoshihide Kanemaki, Koichiro Tsugawa, Takahiko Ueno, Masayuki Takagi
AIMS: The aim of this study was to develop a computer-aided diagnosis (CADx) system for identifying breast pathology. METHODS: Two sets of 100 consecutive core needle biopsy (CNB) specimens were collected for test and validation studies. All 200 CNB specimens were stained with antibodies targeting oestrogen receptor (ER), synaptophysin and CK14/p63. All stained slides were scanned in a whole-slide imaging system and photographed. The photographs were analysed using software to identify the proportions of tumour cells that were positive and negative for each marker...
June 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28611189/an-evaluation-of-a-coagulation-system-xprecia-stride-for-utilisation-in-anticoagulation-management
#3
Deborah McCahon, Andrea Roalfe, David A Fitzmaurice
AIM: To evaluate the reliability and performance of the Xprecia Stride coagulometer under the conditions in which it is most likely to be used. METHODS: The performance of the Xprecia Stride coagulometer was compared with a local laboratory and the CoaguChek systems routinely used for international normalised ratio (INR) estimation within one primary and one secondary care based anticoagulation clinic in Birmingham. Anticoagulation clinic personnel were trained to use the Xprecia Stride...
June 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28611188/new-quantitative-features-for-the-morphological-differentiation-of-abnormal-lymphoid-cell-images-from-peripheral-blood
#4
Laura Puigví, Anna Merino, Santiago Alférez, Andrea Acevedo, José Rodellar
AIMS: This work aims to propose a set of quantitative features through digital image analysis for significant morphological qualitative features of different cells for an objective discrimination among reactive, abnormal and blast lymphoid cells. METHODS: Abnormal lymphoid cells circulating in peripheral blood in chronic lymphocytic leukaemia, B-prolymphocytic leukaemia, hairy cell leukaemia, splenic marginal zone lymphoma, mantle cell lymphoma, follicular lymphoma, T-prolymphocytic leukaemia, T large granular lymphocytic leukaemia and Sézary syndrome, normal, reactive and blast lymphoid cells were included...
June 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28607123/plasma-levels-of-intact-and-cleaved-urokinase-plasminogen-activator-receptor-upar-in-men-with-clinically-localised-prostate-cancer
#5
Gitte Kristensen, Kasper Drimer Berg, Solvej Lippert, Ib Jarle Christensen, Klaus Brasso, Gunilla Høyer-Hansen, Martin Andreas Røder
AIMS: Lymph node metastasis (N1) is an adverse prognostic factor for men with clinically localised prostate cancer (PCa), but the prediction of N1 disease remains difficult. Urokinase plasminogen activator receptor (uPAR) plays an important role in angiogenesis and tumorigenesis. We analysed whether plasma levels of the soluble uPAR forms uPAR(I-III), uPAR(II-III) and uPAR(I) were associated with the risk of N1 disease in men with clinically localised PCa. METHODS: The present study includes all men (n=518) who underwent radical prostatectomy (RP) for clinically localised PCa, 29 of whom had N1 disease...
June 12, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28600294/cervical-intraepithelial-neoplasia-cin-in-african-women-living-with-hiv-role-and-effect-of-rigorous-histopathological-review-by-a-panel-of-pathologists-in-the-harp-study-endpoint-determination
#6
Sylviane Doutre, Tanvier Omar, Olga Goumbri-Lompo, Helen Kelly, Omar Clavero, Souleymane Zan, Admire Chikandiwa, Bernard Sawadogo, Sinead Delany-Moretlwe, Valérie Costes, Philippe Mayaud, Michel Segondy
AIMS: To analyse the effect of the expert end-point committee (EPC) review on histological endpoint classification of cervical intraepithelial neoplasia (CIN). METHODS: A cohort of women living with HIV were recruited in Burkina Faso (BF) and South Africa (SA) and followed over 18 months. Four-quadrant cervical biopsies were obtained in women with abnormalities detected by at least one screening test. A central review by a panel of five pathologists was organised at baseline and at endline...
June 9, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28596154/3d-printed-pathological-sectioning-boxes-to-facilitate-radiological-pathological-correlation-in-hepatectomy-cases
#7
Andrew T Trout, Matthew R Batie, Anita Gupta, Rachel M Sheridan, Gregory M Tiao, Alexander J Towbin
Radiogenomics promises to identify tumour imaging features indicative of genomic or proteomic aberrations that can be therapeutically targeted allowing precision personalised therapy. An accurate radiological-pathological correlation is critical to the process of radiogenomic characterisation of tumours. An accurate correlation, however, is difficult to achieve with current pathological sectioning techniques which result in sectioning in non-standard planes. The purpose of this work is to present a technique to standardise hepatic sectioning to facilitateradiological-pathological correlation...
June 8, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28596153/immunohistochemistry-on-old-archival-paraffin-blocks-is-there-an-expiry-date
#8
Federica Grillo, Martina Bruzzone, Simona Pigozzi, Stefano Prosapio, Paola Migliora, Roberto Fiocca, Luca Mastracci
Few studies have focused on antigen preservation in formalin-fixed and paraffin-embedded (FFPE) tissue in old archival material and additional studies are required, especially considering that these samples are an irreplaceable resource for scientific and clinical research. The purpose of this study is to verify antigen preservation in FFPE tissue samples stored for several decades. From the pathology archives, FFPE blocks were selected dating back to the 1960s, 1970s, 1980s, 1990s, 2000s and 2010. A panel of 12 antibodies was applied and immunoreactivities were compared...
June 8, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28554891/dna-repair-gene-expressions-are-related-to-bone-marrow-cellularity-in-myelodysplastic-syndrome
#9
Howard L Ribeiro, Allan Rodrigo S Maia, Roberta Taiane G de Oliveira, Marília Braga Costa, Izabelle Rocha Farias, Daniela de Paula Borges, Juliana Cordeiro de Sousa, Silvia Maria M Magalhães, Ronald F Pinheiro
OBJECTIVE: To evaluate the expression of genes related to nuclear excision (ERCC8, XPA and XPC), homologous recombination and non-homologous end-joining (ATM, BRCA1, BRCA2 and LIG4) repair mechanisms, using quantitative PCR methodologies, and it relation with bone marrow cellularity in myelodysplastic syndrome (MDS). METHODS AND RESULTS: A total of 51 adult de novo patients with MDS (3 refractory anaemia (RA), 11 refractory anaemia with ringed sideroblasts (RARS), 28 refractory cytopenia with multilineage dysplasia (RCMD), 3 refractory anaemia with excess blasts type I (RAEB-I), 5 refractory anaemia with excess blasts type II (RAEB-II), and 1 chronic myelomonocytic leukaemia (CMML) were evaluated...
May 29, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28554890/atypical-aspirates-of-the-breast-a-dilemma-in-current-cytology-practice
#10
Shuang-Ni Yu, Joshua Li, Sio-In Wong, Julia Y S Tsang, Yun-Bi Ni, Jie Chen, Gary M Tse
AIMS: The probabilistic approach is widely adopted for breast fine needle aspiration cytology. However, a definite cytological diagnosis is not always possible for C3 (atypia) cases, which poses a management dilemma as this represents a mixed category of benign and malignant cases. It would be beneficial to be able to predict malignancy based on specific cytological features in C3 aspirates. METHODS: A comprehensive panel of cytological features (including quantitative, cytomorphological and background features) in a large cohort of C3 breast aspirates with subsequent histological excisions was evaluated to identify relevant morphological criteria predicting the risk of subsequent malignancy...
May 29, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28465449/characteristics-associated-with-requests-by-pathologists-for-second-opinions-on-breast-biopsies
#11
Berta M Geller, Heidi D Nelson, Donald L Weaver, Paul D Frederick, Kimberly H Allison, Tracy Onega, Patricia A Carney, Anna N A Tosteson, Joann G Elmore
AIMS: Second opinions in pathology improve patient safety by reducing diagnostic errors, leading to more appropriate clinical treatment decisions. Little objective data are available regarding the factors triggering a request for second opinion despite second opinion consultations being part of the diagnostic system of pathology. Therefore we sought to assess breast biopsy cases and interpreting pathologists characteristics associated with second opinion requests. METHODS: Collected pathologist surveys and their interpretations of 60 test set cases were used to explore the relationships between case characteristics, pathologist characteristics and case perceptions, and requests for second opinions...
May 2, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28450387/composite-biomarker-panel-for-prediction-of-severity-and-diagnosis-of-acute-gvhd-with-t-cell-depleted-allogeneic-stem-cell-transplants-single-centre-pilot-study
#12
San San Min, Varun Mehra, Jennifer Clay, Gemma F Cross, Abdel Douiri, Tracy Dew, Tanya N Basu, Victoria Potter, M Mansour Ceesay, Antonio Pagliuca, Roy A Sherwood, Royce P Vincent
AIMS: Acute graft-versus-host disease (aGVHD) is a leading cause of morbidity and mortality following allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this study was to evaluate the clinical utility of a composite biomarker panel to help identify individuals at risk of developing aGVHD, and to help predict and differentiate between severity of aGVHD following T-cell-depleted allogeneic HSCT. METHODS: We retrospectively analysed our cohort of biopsy confirmed patients with aGVHD, who underwent T-cell-depleted HSCT and matched them with negative controls without any evidence of aGVHD...
April 27, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28450386/update-on-congenital-heart-disease-and-sudden-infant-perinatal-death-from-history-to-future-trends
#13
REVIEW
Giulia Ottaviani, L Maximilian Buja
During the 20th century, expert pathologists contributed an in-depth characterisation of the anatomical pathology and associated pathophysiology of congenital heart disease (CHD). Starting in the 1970s, the reported CHD birth prevalence has been increasing, owing to advances in diagnostic methods. Over the years, surgical treatments have been associated with an enormous reduction of CHD mortality. Advances also have been made in understanding the developmental biology and molecular pathogenesis of CHD. In developed countries, sudden infant death syndrome (SIDS) is the most frequent form of death during the first year of life, with a death rate of 0...
April 27, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28446541/nuclear-survivin-expression-correlates-with-endoglin-assessed-microvascularisation-in-laryngeal-carcinoma
#14
Gino Marioni, Giancarlo Ottaviano, Rosario Marchese-Ragona, Elena Fasanaro, Giulia Tealdo, Claudia Zanotti, Benedetto Randon, Luciano Giacomelli, Edoardo Stellini, Stella Blandamura
AIMS: Survivin-a member of the family of inhibitor of apoptosis proteins that control cell division, apoptosis and metastasis-is overexpressed in virtually all human cancers, including laryngeal squamous cell carcinoma (LSCC). Recent findings also correlate survivin expression with the regulation of angiogenesis. The novel main aim of this study was a preliminary investigation into the potential role of survivin expression in LSCC neoangiogenesis, as determined by endoglin-assessed microvascular density (MVD)...
April 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28438831/pathology-and-radiology-taking-medical-hermeneutics-to-the-next-level
#15
EDITORIAL
Runjan Chetty
No abstract text is available yet for this article.
April 24, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28428285/characterisation-of-gata3-expression-in-invasive-breast-cancer-differences-in-histological-subtypes-and-immunohistochemically-defined-molecular-subtypes
#16
Shao Xian Tang, Bao Hua Yu, Xiao Li Xu, Yu Fan Cheng, Xiao Yu Tu, Hong Fen Lu, Rui Bi, Xiang Jie Sun, Ruo Hong Shui, Wen Tao Yang
AIMS: GATA-binding protein 3 (GATA3) is a sensitive and relatively specific marker in breast and urothelial carcinomas. Its diagnostic utility in primary and metastatic breast cancers has been explored and confirmed. However, the relationship between GATA3 expression and different breast carcinoma intrinsic subtypes has not been specifically defined in the literature despite a few reports with a small number of cases. The aim of the current investigation is to clarify GATA3 expression among different histological subtypes and surrogate molecular breast carcinoma subtypes in a large series of cases...
April 20, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28428284/acute-presentation-of-autoimmune-hepatitis-a-multicentre-study-with-detailed-histological-evaluation-in-a-large-cohort-of-patients
#17
Hiep Nguyen Canh, Kenichi Harada, Hirofumi Ouchi, Yasunori Sato, Koichi Tsuneyama, Masayoshi Kage, Masayuki Nakano, Kaname Yoshizawa, Atsushi Takahashi, Masanori Abe, Jong-Hon Kang, Kazuhiko Koike, Ayano Inui, Tomoo Fujisawa, Akinobu Takaki, Teruko Arinaga-Hino, Takuji Torimura, Yoshiyuki Suzuki, Keiichi Fujiwara, Mikio Zeniya, Hiromasa Ohira, Atsushi Tanaka, Hajime Takikawa
AIMS: Although liver biopsy is crucial to diagnose and guide treatment decisions, a detailed histological analysis of autoimmune hepatitis (AIH) with clinically acute presentations has not yet been performed. This study aimed to characterise the histological features and explore potential histological hallmarks to diagnose the acute presentation of AIH. METHODS: We systematically evaluated liver specimens of 87 adult patients with acute presentation of AIH retrospectively enrolled from Japanese multicentre facilities...
April 20, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28424237/absence-of-smad9-v90m-mutation-in-juvenile-polyposis-syndrome
#18
LETTER
Lysanne D C Graafmans, Folkert H M Morsink, G Johan A Offerhaus, Francis M Giardiello, Lodewijk A A Brosens
No abstract text is available yet for this article.
April 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28424236/hyalinizing-trabecular-tumour-of-the-thyroid-fine-needle-aspiration-cytological-diagnosis-and-correlation-with-histology
#19
REVIEW
Chiara Saglietti, Simonetta Piana, Stefano La Rosa, Massimo Bongiovanni
Hyalinizing trabecular tumour (HTT) is a rare thyroid neoplasm of follicular cell origin characterised by a trabecular growth pattern and prominent intratrabecular and intertrabecular hyalinisation. These peculiar histological features allow the prompt recognition of this neoplasm in surgical specimens. However, cytological diagnosis of HTT remains elusive and misleading because of overlapping characteristics with other thyroid tumours, particularly papillary thyroid carcinoma (PTC), medullary thyroid carcinoma (MTC) and the newly described non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)...
April 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28424235/increased-alloimmunisation-and-transfusion-reaction-reporting-in-patients-with-solid-phase-panreactivity
#20
Andrea M Olofson, Rachael M Chandler, Cynthia R Marx-Wood, Craig A Babcock, Nancy M Dunbar
BACKGROUND: Automated solid-phase antibody screening uses red blood cell (RBC) membranes immobilised on polystyrene test wells to detect RBC specific antibodies. Despite its time-saving and labour-saving benefits, this method produces a higher rate of nonspecific reactivity compared with manual screening. Solid-phase panreactivity (SPP) is characterised by panreactivity (ie, all test cells reacting) in solid-phase testing accompanied by a negative autocontrol and a lack of reactivity when the same screening cells are tested in tube...
April 19, 2017: Journal of Clinical Pathology
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