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Journal of Clinical Pathology

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https://www.readbyqxmd.com/read/28082414/thyroid-cytology-histology-correlation-using-the-rcpath-terminology-for-thyroid-cytology-reporting
#1
D Parkinson, S Aziz, R Bentley, S J Johnson
AIMS: The Royal College of Pathologists Thy1-5 thyroid cytology guidance, 2009, second edition 2016, invites audits of its use. This report documents the experience of one department, assessing percentage usage of each Thy category, correlation with subsequent histology and comparison with other published studies. METHODS: Thyroid cytology and subsequent histology reports for 7 years (1 January 2008-31 December 2014) were reviewed, excluding referrals. Years 2008-2010 were compared with 2011-2014...
January 12, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28073996/estimate-of-false-positive-breast-cancer-diagnoses-from-accuracy-studies-a-systematic-review
#2
REVIEW
Nereo Segnan, Silvia Minozzi, Antonio Ponti, Cristina Bellisario, Sara Balduzzi, Marien González-Lorenzo, Silvia Gianola, Paola Armaroli
BACKGROUND: False-positive histological diagnoses have the same consequences of overdiagnosis in terms of unnecessary treatment. The aim of this systematic review is to assess their frequency at needle core biopsy (CB) and/or surgical excision of the breast. METHODS: PubMed, Embase, Cochrane Library were systematically searched up to 30 October 2015. Eligibility criteria: cross-sectional studies assessing diagnostic accuracy of CB compared with surgical excision; studies assessing reproducibility of pathologists reading the same slides...
January 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28073995/a-pericentric-inversion-of-chromosome-x-disrupting-f8-and-resulting-in-haemophilia-a
#3
Yu Xin, Jingyi Zhou, Qiulan Ding, Changming Chen, Xi Wu, Xuefeng Wang, Hongli Wang, Xiaofeng Jiang
AIMS: The frequency of X chromosome pericentric inversion is much less than that of autosome chromosome. We hereby characterise a pericentric inversion of X chromosome associated with severe factor VIII (FVIII) deficiency in a sporadic haemophilia A (HA) pedigree. METHODS: PCR primer walking and genome walking strategies were adopted to identify the exact breakpoints of the inversion. Copy number variations (CNVs) of the F8 and the whole chromosomes were detected by AccuCopy and Affymetrix CytoScan High Definition (HD) assays, respectively...
January 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28069628/cushing-s-syndrome-a-practical-approach-to-diagnosis-and-differential-diagnoses
#4
Joseph M Pappachan, Christian Hariman, Mahamood Edavalath, Julian Waldron, Fahmy W Hanna
Diagnosis of Cushing's syndrome (CS) and identification of the aetiology of hypercortisolism can be challenging. The Endocrine Society clinical practice guidelines recommends one of the four tests for initial screening of CS, namely, urinary-free cortisol, late night salivary cortisol, overnight dexamethasone suppression test or a longer low-dose dexamethasone suppression test, for 48 hours. Confirmation and localisation of CS requires additional biochemical and radiological tests. Radiological evaluation involves different imaging modalities including MRI with or without different radio-nuclear imaging techniques...
January 9, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28062660/digital-pathology-in-the-diagnostic-setting-beyond-technology-into-best-practice-and-service-management
#5
Chee Leong Cheng, Puay Hoon Tan
Digital pathology (DP) and whole-slide imaging (WSI) technology have matured substantially over the last few years and there is growing evidence from validation studies that WSI is comparable to glass slides for histopathology diagnosis, although with some limitations, which can be appropriately minimised. Whether the controlled environment of validation studies translates to the same level of robustness when WSI is used in the actual diagnostic setting depends on the technical quality of WSI acquisition and on factors that influence the pre-image acquisition variables including the quality of glass slide inputs, and postimage acquisition variables such as access and use of WSI...
January 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28062659/bone-marrow-biopsies-performed-by-both-the-powered-oncontrol-drill-device-and-the-jamshidi-needle-produce-adequate-specimens
#6
Sarika Jain, Mark Enzerra, Rohtesh S Mehta, Roy Smith, Miroslav Djokic
OBJECTIVE: The aim of our study was to evaluate the adequacy and quality of the bone marrow (BM) obtained by OnControl powered drill (P-group) and to compare it with manual procedure (M-group). DESIGN: Retrospective analysis was done on 75 BM specimens; Jamshidi needle (n=44) and OnControl (n=31). Biopsy length after fixation, evaluable marrow length and total area, and fragmentation, aspiration and marrow dropout artefacts were compared. RESULTS: Biopsies were sufficient for diagnosis in 38/44 cases (86%) in the M-group and in 26/31 cases (83%) in the P-group...
January 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28062658/practical-thoracic-pathology-diseases-of-the-lung-heart-and-thymus
#7
Zanobia Khan
No abstract text is available yet for this article.
January 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28062657/fatal-fungal-endocarditis-in-a-patient-with-primary-antibody-deficiency
#8
LETTER
Gabriel K Wong, Laura Z King, M Stephens, Aarnoud P Huissoon
No abstract text is available yet for this article.
January 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28011578/prognostic-implications-of-rasal1-expression-in-oesophagogastric-adenocarcinoma
#9
LETTER
Juliana Knief, Katharina Reddemann, Pamela Lazar-Karsten, Tobias Herhahn, Ekaterina Petrova, Ulrich Wellner, Christoph Thorns
No abstract text is available yet for this article.
December 23, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28011577/examining-the-potential-use-and-long-term-stability-of-guaiac-faecal-occult-blood-test-cards-for-microbial-dna-16s-rrna-sequencing
#10
Morag Taylor, Henry M Wood, Stephen P Halloran, Philip Quirke
AIMS: With a growing interest in the influence the gut microbiome has on the development of colorectal cancer (CRC), we investigated the feasibility and stability of isolating and typing microbial DNA from guaiac faecal occult blood test (gFOBt) cards. This has the future potential to screen the microbial populations present in confirmed colorectal neoplasia cases with aims to predict the presence and development of CRC. METHODS: Fresh stool samples from three healthy volunteers were applied to gFOBt cards...
December 23, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27993946/anaplastic-lymphoma-kinase-expression-and-gene-alterations-in-glioblastoma-correlations-with-clinical-outcome
#11
George Karagkounis, George Stranjalis, Theodore Argyrakos, Varvara Pantelaion, Konstantinos Mastoris, Dimitra Rontogianni, Spyridon Komaitis, Theodosis Kalamatianos, Damianos Sakas, Dina Tiniakos
AIMS: To study anaplastic lymphoma kinase (ALK) protein expression and possible underlying gene alterations in glioblastoma (GBM), correlating them with clinical outcome. METHODS: We studied ALK immunohistochemical expression and fluorescent in situ hybridisation (FISH)-detected ALK gene alterations in 51 GBMs (46 isocitrate dehydrogenase-1 (IDH1)(R132H)-negative and 5 IDH-mutant (IDH1(R132H)-positive)). We compared two anti-ALK antibodies and immunohistochemical detection systems (5Α4/Nichirei Biosciences, D5F3/Ventana)...
December 19, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27993945/human-polyomavirus-dna-detection-in-keratoacanthoma-and-spitz-naevus-no-evidence-for-a-causal-role
#12
Linnea Haeggblom, Joar Franzén, Anders Näsman
Keratoacanthomas (KA) and Spitz naevus (SN) are both lesions with unknown aetiology; therefore, the possibility of a viral involvement, more specifically the involvement of human polyomaviruses (HPyV), was investigated. In total, 22 cases of KA and 25 cases of SN were tested for the presence of HPyVs. DNA was extracted and amplified by multiplex PCR and thereafter tested with a multiplex bead-based assay for HPyVs (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, TSPyV, HPyV6, 7 and 9) and two primate viruses (SV40 and LPyV)...
December 19, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27980054/reduced-angiomotin-p130-expression-correlates-with-poor-prognosis-in-lung-adenocarcinoma
#13
Si-Hyong Jang, Hyun Deuk Cho, Ji-Hye Lee, Hyun Ju Lee, Soon Auck Hong, Junhun Cho, Han Jo Kim, Mee-Hye Oh
AIMS: Lung cancer is the leading cause of cancer-related deaths worldwide, and it still results in a poor prognosis despite research and development of a treatment modality. Angiomotin (AMOT) was first described as a protein involved in angiogenesis, and although the oncogenic and tumour-suppressive roles of AMOT were recently reported, the biological function of AMOT has not yet been clarified. The aim of this study was thus to evaluate the relationship between reduced AMOT p130 expression and clinicopathological parameters, including patients' survival...
December 15, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27980053/performance-of-urinalysis-tests-and-their-ability-in-predicting-results-of-urine-cultures-a-comparison-between-automated-test-strip-analyser-and-flow-cytometry-in-various-subpopulations-and-types-of-samples
#14
Erlangga Yusuf, Bruno Van Herendael, Jef van Schaeren
AIMS: Results of urinalysis are available earlier than urine culture results. If urinalysis can predict results of culture, early decision can be made on treatment and whether urine samples should be cultured. This study sought to compare the performance of urinalysis tests by automated test strip analyser (nitrite and leucocyte esterase) with flow cytometry (bacteria and white cell count) in different subpopulations and types of samples. METHODS: Consecutive urine samples (n=2351) from a population with a median age of 45 years, 37...
December 15, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27980052/clinicopathological-significance-of-necl-4-expression-in-pancreatic-ductal-adenocarcinoma
#15
Aya Kawanishi, Kenichi Hirabayashi, Misuzu Yamada, Yumi Takanashi, Atsuko Hadano, Yoshiaki Kawaguchi, Toshio Nakagohri, Naoya Nakamura, Tetsuya Mine
AIMS: The loss, or decreased expression, of nectin-like molecule 4 (Necl-4; an immunoglobulin-like cell adhesion molecule) is reported to be associated with the development and progression of certain types of cancer. We investigated the clinicopathological significance of Necl-4 expression in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Immunohistochemical analyses of Necl-4 (n=258) and E-cadherin (n=256) expression were performed using tissue microarray blocks of PDAC samples...
December 15, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27941028/intra-abdominal-candida-spp-infection-in-acute-abdomen-in-a-quality-assurance-qa-certified-academic-setting
#16
Vito Rodolico, Paola Di Carlo, Gaspare Gulotta, Francesco D'Arpa, Giuseppe Salamone, Gianfranco Cocorullo, Antonino Agrusa, Anna Giammanco, Consolato Sergi
AIMS: To evaluate the contribution of light microscopy to detecting Candida spp infection in patients with complicated intra-abdominal infections (IAIs) admitted for acute abdomen to a quality assurance (QA)-certified surgical emergency ward. METHODS: We conducted a retrospective study (2008-2012) of 809 abdominal intraoperative or biopsy tissue specimens obtained from patients admitted with acute abdomen and microbiological samples positive for Candida spp. Demographic data, mortality, comorbidities, specimen type, microscopy results, special histological staining performed, antimicrobial therapy were collected and analysed...
December 9, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27932667/lymph-node-yield-is-an-independent-predictor-of-survival-in-rectal-cancer-regardless-of-receipt-of-neoadjuvant-therapy
#17
Zhaomin Xu, Mariana E Berho, Adan Z Becerra, Christopher T Aquina, Bradley J Hensley, Reza Arsalanizadeh, Katia Noyes, John R T Monson, Fergal J Fleming
AIMS: Lymph node yield (LNY) is used as a marker of adequate oncological resection. The American Joint Committee on Cancer (AJCC) currently recommends that at least 12 nodes are necessary to confirm node-negative disease for rectal cancer. A LNY of 12 is not always achieved, particularly in patients who have undergone neoadjuvant treatment. This study attempts to examine factors associated with LNY and its prognostic impact following neoadjuvant chemoradiation in rectal cancer. METHODS: The 2006-2011 National Cancer Data Base was queried for patients with clinical stage I-III rectal cancer who underwent a proctectomy...
December 8, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27927694/th9-cytokines-response-and-its-possible-implications-in-the-immunopathogenesis-of-leprosy
#18
Jorge Rodrigues de Sousa, Carla Pagliari, Dandara Simone Maia de Almeida, Luiz Fernando Lima Barros, Francisca Regina Oliveira Carneiro, Leonidas Braga Dias, Tinara Leila de Souza Aarão, Juarez Antonio Simões Quaresma
AIMS: Leprosy is an infectious-contagious disease whose clinical evolution depends on the interaction of the infectious agent with the immune response of the host, leading to a clinical spectrum that ranges from lepromatous leprosy (susceptibility, LL) to tuberculoid leprosy (resistance, TT). The immune response profile will depend on the pattern of cytokine production and on the activity of macrophages during infection. Classically, the clinical evolution of leprosy has been associated with Th1/Th2 cytokine profiles, but the role of new cytokine profiles such as T helper 9 (Th9) remains to be elucidated...
December 7, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27920043/a-historical-perspective-on-crush-syndrome-the-clinical-application-of-its-pathogenesis-established-by-the-study-of-wartime-crush-injuries
#19
REVIEW
Dilini Peiris
Crush syndrome is a fine example of how pathology can play a direct role in revealing the best treatment and management for diseases. It can occur when crush injuries are sustained. Skeletal muscle becomes damaged under the weight of a heavy object, and victims experience severe shock and renal failure. The discovery of the pathology of crush syndrome belongs to two individuals: Seigo Minami and Eric Bywaters. They separately helped to define the pathogenesis of crush syndrome during World Wars I and II. Seigo Minami is believed to have been the first to record the pathogenesis of crush syndrome...
December 5, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27899414/sentinel-case-of-richter-transformation-from-chronic-lymphocytic-leukaemia-small-lymphocytic-lymphoma-to-cd3-diffuse-large-b-cell-lymphoma
#20
Ali Ismail, Jawed A Mallick, Dahui Qin, Mohammad O Hussaini
AIM: To report the first case of a Richter syndrome where small lymphocytic lymphoma (SLL) progressed to a CD3+ diffuse large B-cell lymphoma (DLBCL). METHODS: Macrodissection of small and large cell lymphomatous components was performed. This was followed by flow cytometric analysis along with molecular B-cell immunoglobulin (heavy and light chains) and T-cell receptor (γ and β chains) gene rearrangement studies to investigate a clonal relationship between the components...
November 29, 2016: Journal of Clinical Pathology
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