journal
Journals Biochemistry. Biokhimii︠a...

Biochemistry. Biokhimii︠a︡

https://read.qxmd.com/read/38467554/impairment-of-assembly-of-the-vimentin-intermediate-filaments-leads-to-suppression-of-formation-and-maturation-of-focal-contacts-and-alteration-of-the-type-of-cellular-protrusions
#1
JOURNAL ARTICLE
Anna O Zholudeva, Nikolay S Potapov, Ekaterina A Kozlova, Maria E Lomakina, Antonina Y Alexandrova
Cell migration is largely determined by the type of protrusions formed by the cell. Mesenchymal migration is accomplished by formation of lamellipodia and/or filopodia, while amoeboid migration is based on bleb formation. Changing of migrational conditions can lead to alteration in the character of cell movement. For example, inhibition of the Arp2/3-dependent actin polymerization by the CK-666 inhibitor leads to transition from mesenchymal to amoeboid motility mode. Ability of the cells to switch from one type of motility to another is called migratory plasticity...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467553/synthesis-and-biological-properties-of-polyphenol-containing-linear-and-dendrimeric-cationic-peptides
#2
JOURNAL ARTICLE
Artem A Shatilov, Sergey M Andreev, Anastasiya V Shatilova, Evgeny A Turetskiy, Renata A Kurmasheva, Marina O Babikhina, Larisa V Saprygina, Nadezhda N Shershakova, Dar'ya K Bolyakina, Valeriy V Smirnov, Igor P Shilovsky, Musa R Khaitov
Natural polyphenols are promising compounds for the pharmacological control of oxidative stress in various diseases. However, low bioavailability and rapid metabolism of polyphenols in a form of glycosides or aglycones have stimulated the search for the vehicles that would provide their efficient delivery to the systemic circulation. Conjugation of polyphenols with cationic amphiphilic peptides yields compounds with a strong antioxidant activity and ability to pass through biological barriers. Due to a broad range of biological activities characteristic of polyphenols and peptides, their conjugates can be used in the antioxidant therapy, including the treatment of viral, oncological, and neurodegenerative diseases...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467552/the-functions-of-n-6-methyladenosine-in-nuclear-rnas
#3
REVIEW
Nadezhda A Zhigalova, Katerina Yu Oleynikova, Alexey S Ruzov, Alexander S Ermakov
N6 -methyladenosine (m6 A) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that m6 A methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of m6 A-related studies have been focused on the cytoplasmic functions of this modification. Here, we review new data on the role of m6 A in several key biological processes taking place in the cell nucleus, such as transcription, chromatin organization, splicing, nuclear-cytoplasmic transport, and R-loop metabolism...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467551/serum-glycome-as-a-diagnostic-and-prognostic-factor-in-gestational-diabetes-mellitus
#4
JOURNAL ARTICLE
Ognjen Radojičić, Lucia Pažitná, Zorana Dobrijević, Paras Kundalia, Kristina Kianičková, Jaroslav Katrlík, Vesna Mandić Marković, Željko Miković, Olgica Nedić, Dragana Robajac
Gestational diabetes mellitus (GDM) is a risk factor for both mother and fetus/neonate during and after the pregnancy. Inconsistent protocols and cumbersome screening procedures warrant the search for new and easily accessible biomarkers. We investigated a potential of serum N-glycome to differentiate between healthy pregnant women (n = 49) and women with GDM (n = 53) using a lectin-based microarray and studied the correlation between the obtained data and parameters of glucose and lipid metabolism. Four out of 15 lectins used were able to detect the differences between the control and GDM groups in fucosylation, terminal galactose/N-acetylglucosamine (Gal/GlcNAc), presence of Galα1,4Galβ1,4Glc (Gb3 antigen), and terminal α2,3-sialylation with AUC values above 60%...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467550/pathogenetic-significance-of-long-non-coding-rnas-in-the-development-of-thoracic-and-abdominal-aortic-aneurysms
#5
REVIEW
Aksana N Kucher, Iuliia A Koroleva, Maria S Nazarenko
Aortic aneurysm (AA) is a life-threatening condition with a high prevalence and risk of severe complications. The aim of this review was to summarize the data on the role of long non-coding RNAs (lncRNAs) in the development of AAs of various location. Within less than a decade of studies on the role of lncRNAs in AA, using experimental and bioinformatic approaches, scientists have obtained the data confirming the involvement of these molecules in metabolic pathways and pathogenetic mechanisms critical for the aneurysm development...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467549/n-terminal-fragment-of-cardiac-myosin-binding-protein-c-modulates-cooperative-mechanisms-of-thin-filament-activation-in-atria-and-ventricles
#6
JOURNAL ARTICLE
Anastasia M Kochurova, Evgenia A Beldiia, Victoria V Nefedova, Natalia S Ryabkova, Daria S Yampolskaya, Alexander M Matyushenko, Sergey Y Bershitsky, Galina V Kopylova, Daniil V Shchepkin
Cardiac myosin binding protein C (cMyBP-C) is one of the essential control components of the myosin cross-bridge cycle. The C-terminal part of cMyBP-C is located on the surface of the thick filament, and its N-terminal part interacts with actin, myosin, and tropomyosin, affecting both kinetics of the ATP hydrolysis cycle and lifetime of the cross-bridge, as well as calcium regulation of the actin-myosin interaction, thereby modulating contractile function of myocardium. The role of cMyBP-C in atrial contraction has not been practically studied...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467548/leaf-extract-from-european-olive-olea-europaea-l-post-transcriptionally-suppresses-the-epithelial-mesenchymal-transition-and-sensitizes-gastric-cancer-cells-to-chemotherapy
#7
JOURNAL ARTICLE
Cagla Tekin, Melis Ercelik, Pavel Dunaev, Aigul Galembikova, Gulcin Tezcan, Secil Ak Aksoy, Ferah Budak, Ozgen Isık, Nesrin Ugras, Sergei Boichuk, Berrin Tunca
The overall survival of patients with the advanced and recurrent gastric cancer (GC) remains unfavorable. In particular, this is due to cancer spreading and resistance to chemotherapy associated with the epithelial-mesenchymal transition (EMT) of tumor cells. EMT can be identified by the transcriptome profiling of GC for EMT markers. Indeed, analysis of the TCGA and GTEx databases (n = 408) and a cohort of GC patients (n = 43) revealed that expression of the CDH2 gene was significantly decreased in the tumors vs...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467547/genomic-imprinting-and-random-monoallelic-expression
#8
REVIEW
Yaroslava V Lobanova, Svetlana V Zhenilo
The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects of studies of the monoallelic expression are discussed.
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467546/immunology-of-sars-cov-2-infection
#9
REVIEW
Aida G Gabdoulkhakova, Rimma N Mingaleeva, Albina M Romozanova, Aisylu R Sagdeeva, Yulia V Filina, Albert A Rizvanov, Regina R Miftakhova
According to the data from the World Health Organization, about 800 million of the world population had contracted coronavirus infection caused by SARS-CoV-2 by mid-2023. Properties of this virus have allowed it to circulate in the human population for a long time, evolving defense mechanisms against the host immune system. Severity of the disease depends largely on the degree of activation of the systemic immune response, including overstimulation of macrophages and monocytes, cytokine production, and triggering of adaptive T- and B-cell responses, while SARS-CoV-2 evades the immune system actions...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467545/influence-of-nucleotide-context-on-non-specific-amplification-of-dna-with-bst-exo-dna-polymerase
#10
JOURNAL ARTICLE
Ravil R Garafutdinov, Olga Yu Kupova, Assol R Sakhabutdinova
Isothermal nucleic acids amplification that requires DNA polymerases with strand-displacement activity gained more attention in the last two decades. Among the DNA polymerases with strand-displacement activity, Bst exo- is the most widely used. However, it tends to carry out nonspecific DNA synthesis through multimerization. In this study, the effect of nucleotide sequence on the Bst exo- binding with DNA and on the efficiency of multimerization initiation, are reported. Preference for binding of the "closed" form of Bst exo- to the purine-rich DNA sequences, especially those containing dG at the 3'-end of the growing chain was revealed using molecular docking of the single-stranded trinucleotides (sst) and trinucleotide duplexes (dst)...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467544/synthetic-activators-of-autophagy
#11
REVIEW
Ekaterina A Guseva, Julia A Pavlova, Olga A Dontsova, Petr V Sergiev
Autophagy is a central process for degradation of intracellular components that do not operate correctly. Molecular mechanisms underlying this process are extremely difficult to study, since they involve a large number of participants. The main task of autophagy is redistribution of cellular resources in response to environmental changes, such as starvation. Recent studies show that autophagy regulation could be the key to achieve healthy longevity, as well as to create therapeutic agents for treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467543/natural-activators-of-autophagy
#12
REVIEW
Julia A Pavlova, Ekaterina A Guseva, Olga A Dontsova, Petr V Sergiev
Autophagy is the process by which cell contents, such as aggregated proteins, dysfunctional organelles, and cell structures are sequestered by autophagosome and delivered to lysosomes for degradation. As a process that allows the cell to get rid of non-functional components that tend to accumulate with age, autophagy has been associated with many human diseases. In this regard, the search for autophagy activators and the study of their mechanism of action is an important task for treatment of many diseases, as well as for increasing healthy life expectancy...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462459/viral-vectors-in-gene-replacement-therapy
#13
REVIEW
Ekaterina Minskaia, Alima Galieva, Alexander D Egorov, Roman Ivanov, Alexander Karabelsky
Throughout the years, several hundred million people with rare genetic disorders have been receiving only symptom management therapy. However, research and development efforts worldwide have led to the development of long-lasting, highly efficient, and safe gene therapy for a wide range of hereditary diseases. Improved viral vectors are now able to evade the preexisting immunity and more efficiently target and transduce therapeutically relevant cells, ensuring genome maintenance and expression of transgenes at the relevant levels...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462458/phenoptosis-and-the-various-types-of-natural-selection
#14
REVIEW
Giacinto Libertini
In the first description of evolution, the fundamental mechanism is the natural selection favoring the individuals best suited for survival and reproduction (selection at the individual level or classical Darwinian selection). However, this is a very reductive description of natural selection that does not consider or explain a long series of known phenomena, including those in which an individual sacrifices or jeopardizes his life on the basis of genetically determined mechanisms (i.e., phenoptosis). In fact, in addition to (i) selection at the individual level, it is essential to consider other types of natural selection such as those concerning: (ii) kin selection and some related forms of group selection; (iii) the interactions between the innumerable species that constitute a holobiont; (iv) the origin of the eukaryotic cell from prokaryotic organisms; (v) the origin of multicellular eukaryotic organisms from unicellular organisms; (vi) eusociality (e...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462457/changes-in-the-structure-of-potato-virus-a-virions-after-limited-in-situ-proteolysis-according-to-tritium-labeling-data-and-computer-simulation
#15
JOURNAL ARTICLE
Alexander L Ksenofontov, Ludmila A Baratova, Pavel I Semenyuk, Natalia V Fedorova, Gennadii A Badun
Coat proteins (CP) of the potato virus A virions (PVA) contain partially disordered N-terminal domains, which are necessary for performing vital functions of the virus. Comparative analysis of the structures of coat proteins (CPs) in the intact PVA virions and in the virus particles lacking N-terminal 32 amino acids (PVAΔ32) was carried out in this work based on the tritium planigraphy data. Using atomic-resolution structure of the potato virus Y potyvirus (PVY) protein, which is a homolog of the CP PVA, the available CP surfaces in the PVY virion were calculated and the areas of intersubunit/interhelix contacts were determined...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462456/nocistatin-and-products-of-its-proteolysis-are-dual-modulators-of-type-3-acid-sensing-ion-channels-asic3-with-algesic-and-analgesic-properties
#16
JOURNAL ARTICLE
Dmitry I Osmakov, Nadezhda V Tarasova, Andrey A Nedorubov, Victor A Palikov, Yulia A Palikova, Igor A Dyachenko, Yaroslav A Andreev, Sergey A Kozlov
The neuropeptide nocistatin (NS) is expressed by the nervous system cells and neutrophils as a part of a precursor protein and can undergo stepwise limited proteolysis. Previously, it was shown that rat NS (rNS) is able to activate acid-sensing ion channels (ASICs) and that this effect correlates with the acidic nature of NS. Here, we investigated changes in the properties of rNS in the course of its proteolytic degradation by comparing the effects of the full-size rNS and its two cleavage fragments on the rat isoform 3 ASICs (ASIC3) expressed in X...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462455/dicarbonyl-modified-low-density-lipoproteins-are-key-inducers-of-lox-1-and-nox1-gene-expression-in-the-cultured-human-umbilical-vein-endotheliocytes
#17
JOURNAL ARTICLE
Vadim Z Lankin, Mars G Sharapov, Alla K Tikhaze, Ruslan G Goncharov, Olga A Antonova, Galina G Konovalova, Vladimir I Novoselov
Expression of LOX-1 and NOX1 genes in the human umbilical vein endotheliocytes (HUVECs) cultured in the presence of low-density lipoproteins (LDL) modified with various natural dicarbonyls was investigated for the first time. It was found that among the investigated dicarbonyl-modified LDLs (malondialdehyde (MDA)-modified LDLs, glyoxal-modified LDLs, and methylglyoxal-modified LDLs), the MDA-modified LDLs caused the greatest induction of the LOX-1 and NOX1 genes, as well as of the genes of antioxidant enzymes and genes of proapoptotic factors in HUVECs...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462454/opposite-effects-of-crabp1-and-crabp2-homologs-on-proliferation-of-breast-cancer-cells-and-their-sensitivity-to-retinoic-acid
#18
JOURNAL ARTICLE
Adel D Enikeev, Pavel M Abramov, Danila S Elkin, Andrey V Komelkov, Anastasiya A Beliaeva, Darya M Silantieva, Elena M Tchevkina
Resistance of tumor cells to retinoic acid (RA), a promising therapeutic agent, is the major factor limiting the use of RA in clinical practice. The mechanisms of resistance to RA are still poorly understood. Cellular Retinoic Acid Binding Proteins, CRABP1 and CRABP2, are essential mediators of RA signaling, but role of the two CRABP homologs in regulating cellular sensitivity to RA has not been well studied. In addition, the effects of CRABP1 and CRABP2 on cell proliferation have not been compared. Here, using a broad panel of breast cancer cell lines with different levels of RA sensitivity/resistance, we show for the first time that in the RA-sensitive cells, CRABP1 expression is restricted by methylation, and protein levels are highly variable...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462453/effect-of-dexamethasone-on-adhesion-of-human-neutrophils-and-concomitant-secretion
#19
JOURNAL ARTICLE
Svetlana I Galkina, Ekaterina A Golenkina, Natalia V Fedorova, Alexander L Ksenofontov, Marina V Serebryakova, Vladimir I Stadnichuk, Ludmila A Baratova, Galina F Sud'ina
Neutrophils play a dual role in protecting the body. They are able to penetrate infected tissues and destroy pathogens there by releasing aggressive bactericidal substances. While into the surrounding tissues, the aggressive products secreted by neutrophils initiate development of inflammatory processes. Invasion of neutrophils into tissues is observed during the development of pneumonia in the patients with lung diseases of various etiologies, including acute respiratory distress syndrome caused by coronavirus disease...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38462452/low-frequency-oscillations-of-bacteriochlorophyll-oligomers-in-chlorosomes-of-photosynthetic-green-bacteria
#20
JOURNAL ARTICLE
Andrei G Yakovlev, Alexandra S Taisova, Zoya G Fetisova
In green photosynthetic bacteria, light is absorbed by bacteriochlorophyll (BChl) c/d/e oligomers, which are located in chlorosomes - unique structures created by Nature to collect the energy of very weak light fluxes. Using coherent femtosecond spectroscopy at cryogenic temperature, we detected and studied low-frequency vibrational motions of BChl c oligomers in chlorosomes of the green bacteria Chloroflexus (Cfx.) aurantiacus. The objects of the study were chlorosomes isolated from the bacterial cultures grown under different light intensity...
December 2023: Biochemistry. Biokhimii︠a︡
journal
journal
23947
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.