Artem A Shatilov, Sergey M Andreev, Anastasiya V Shatilova, Evgeny A Turetskiy, Renata A Kurmasheva, Marina O Babikhina, Larisa V Saprygina, Nadezhda N Shershakova, Dar'ya K Bolyakina, Valeriy V Smirnov, Igor P Shilovsky, Musa R Khaitov
Natural polyphenols are promising compounds for the pharmacological control of oxidative stress in various diseases. However, low bioavailability and rapid metabolism of polyphenols in a form of glycosides or aglycones have stimulated the search for the vehicles that would provide their efficient delivery to the systemic circulation. Conjugation of polyphenols with cationic amphiphilic peptides yields compounds with a strong antioxidant activity and ability to pass through biological barriers. Due to a broad range of biological activities characteristic of polyphenols and peptides, their conjugates can be used in the antioxidant therapy, including the treatment of viral, oncological, and neurodegenerative diseases...
January 2024: Biochemistry. Biokhimii︠a︡