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Psychosomatic Medicine

Ashley E Mason, Frederick M Hecht, Jennifer J Daubenmier, David A Sbarra, Jue Lin, Patricia J Moran, Samantha G Schleicher, Michael Acree, Aric A Prather, Elissa S Epel
OBJECTIVE: To determine, within a weight-loss clinical trial for obesity, the impact of intervention arm, weight change, and weight-loss maintenance on telomere length (TL). METHODS: Adults (N=194) with a BMI between 30 and 45 were randomized to a 5.5-month weight-loss program with (n=100) or without (n=94) mindfulness training and identical diet-exercise guidelines. We assessed TL at baseline and 3, 6, and 12 months post-baseline in immune cell populations (primarily in peripheral blood mononuclear cells [PBMCs], but also in granulocytes and T and B lymphocytes)...
June 12, 2018: Psychosomatic Medicine
Tiffany L Carson, Fuchenchu Wang, Xiangqin Cui, Bradford E Jackson, William J Van Der Pol, Elliot J Lefkowitz, Casey Morrow, Monica L Baskin
OBJECTIVE: Racial health disparities persist among black and white women for colorectal cancer. Understanding racial differences in the gut microbiota and related covariates (e.g., stress) may yield new insight into unexplained colorectal cancer disparities. METHODS: Healthy non-Hispanic black or white females (age ≥19 years) provided survey data, anthropometrics, and stool samples. Fecal DNA was collected and isolated from a wipe. PCR was used to amplify the V4 region of the 16SrRNA gene and 250 bases were sequenced using the MiSeq platform...
June 12, 2018: Psychosomatic Medicine
Laura Ricarda Koenen, Adriane Icenhour, Katarina Forkmann, Nina Theysohn, Michael Forsting, Ulrike Bingel, Sigrid Elsenbruch
OBJECTIVE: The aim of this study was to compare behavioral and neural anticipatory responses to cues predicting either somatic or visceral pain in an associative learning paradigm. METHODS: Healthy women (N=22) underwent functional magnetic resonance imaging. During an acquisition phase, two different visual cues repeatedly signaled either experimental visceral or somatic pain. In a subsequent extinction phase, identical cues were presented without pain. Before and after each phase, cue valence and contingency awareness were assessed on visual analogue scales...
June 4, 2018: Psychosomatic Medicine
Yannick Stephan, Angelina R Sutin, Antonio Terracciano
OBJECTIVE: Subjective age has been implicated in a range of health outcomes. The present study extends existing research by providing new data on the relation between subjective age and mortality in three large national samples. METHODS: Participants (total N > 17,000) were drawn from the Health and Retirement Study (HRS, 2008-2014), the Midlife in the United State Survey (MIDUS, 1995-2014), and the National Health and Aging Trends Study (NHATS, 2011-2014). Subjective age, demographic factors, disease burden, functional limitations, depressive symptoms, and physical inactivity were assessed at baseline and mortality data were tracked for up to 20 years...
June 1, 2018: Psychosomatic Medicine
Christoph Herrmann-Lingen, Mustafa al'Absi
Depression is an established predictor of adverse cardiovascular disease outcomes. Less is known about cardiovascular risk factors as predictors of depression. In this issue of Psychosomatic Medicine, Patel et al. report data indicating that pre-existing hypertension may be associated with the atypical but not typical form of depression. We highlight here the strengths and limitations of the article and discuss the findings in light of research linking blood pressure and emotion regulation. In general, evidence suggests that higher blood pressure is associated with reduced expression of negative emotions and pain...
May 30, 2018: Psychosomatic Medicine
Kalina J Michalska, Julia S Feldman, Rany Abend, Andrea L Gold, Troy C Dildine, Esther E Palacios-Barrios, Ellen Leibenluft, Kenneth E Towbin, Daniel S Pine, Lauren Y Atlas
OBJECTIVE: Naturalistic studies suggest that expectation of adverse experiences such as pain exerts particularly strong effects on anxious youth. In healthy adults, expectation influences the experience of pain. The current study uses experimental methods to compare the effects of expectation on pain among adults, healthy youth, and youth with an anxiety disorder. METHODS: Twenty-three healthy adults, 20 healthy youth, and 20 youth with an anxiety disorder underwent procedures in which auditory cues were paired with noxious thermal stimulation...
May 30, 2018: Psychosomatic Medicine
Marina López-Solà, Leonie Koban, Tor D Wager
OBJECTIVES: Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here we test a novel meaning-based intervention: Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a positive, prosocial meaning context. We predicted that the ventromedial prefrontal cortex (vmPFC), a key structure for pain regulation and generation of affective meaning, would mediate the transformation of pain experience by this prosocial interpersonal context...
May 24, 2018: Psychosomatic Medicine
Keith M Diaz, Anusorn Thanataveerat, Faith E Parsons, Sunmoo Yoon, Ying Kuen Cheung, Carmela Alcantara, Andrea T Duran, Ipek Ensari, David J Krupka, Joseph E Schwartz, Matthew M Burg, Karina W Davidson
OBJECTIVES: The purpose of this study, which used mobile technologies to continuously collect data over 1 year, was to examine the association of psychological stress with objectively measured sedentary behavior in adults at both the group (e.g. nomothetic approach) and individual (e.g. idiographic approach) level. METHODS: Data were collected in an observational study of healthy adults (n=79) residing in the New York City metro area who were studied for 365 days from 2014-2015...
May 24, 2018: Psychosomatic Medicine
Peng Zou, Xiaogang Wang, Lei Sun, Qing Chen, Huan Yang, Niya Zhou, Hongqiang Chen, Guowei Zhang, Xi Ling, Zhi Wang, Jianfang Gao, Min Mo, Linping Huang, Kaige Peng, Sheng Chen, Zhihong Cui, Jinyi Liu, Lin Ao, Jia Cao
OBJECTIVES: Behavioral and psychosocial factors have been associated with a decline of the quality of semen. However, the relationship of depression and physical activity (PA) with semen quality remain unclear. METHODS: Data were obtained from 587 young male Chinese college students in June 2013. Participants completed a questionnaire assessing lifestyle factors, the Zung self-rate depression scale (SDS) and three items related to PA. They underwent a physical examination, and provided a semen sample and a blood sample for reproductive hormones (testosterone, estrogen, progesterone, follicle-stimulating hormone, luteinizing hormone and prolactin)...
May 24, 2018: Psychosomatic Medicine
J Douglas Bremner, Carolina Campanella, Zehra Khan, Majid Shah, Muhammad Hammadah, Kobina Wilmot, Ibhar Al Mheid, Bruno B Lima, Ernest V Garcia, Jonathon Nye, Laura Ward, Michael H Kutner, Paolo Raggi, Brad D Pearce, Amit Shah, Arshed Quyyumi, Viola Vaccarino
OBJECTIVE: Coronary artery disease (CAD) is a major cause of morbidity and mortality, and despite important advances in our understanding of this disorder, the underlying mechanisms remain under investigation. Recently, increased attention has been placed to the role of behavioral factors like emotional stress on CAD risk. Brain areas involved in memory and the stress response, including medial prefrontal cortex, insula and parietal cortex, also have outputs to the peripheral cardiovascular system...
May 24, 2018: Psychosomatic Medicine
Stefano Magon, Till Sprenger, Alexander Otti, Athina Papadopoulou, Harald Gündel, Michael Noll-Hussong
OBJECTIVE: Chronic pain disorder (CPD) has been associated with brain changes, especially in limbic circuits. However, in the majority of patients with chronic pain, depression or anxiety are common comorbidities. In this exploratory and naturalistic study, we investigated brain cortical thickness differences between patients with CPD and healthy controls, with consideration of concurrent psychiatric symptoms. METHODS: Twenty-three patients with CPD and 23 age- and sex-matched healthy volunteers were included in this study...
May 21, 2018: Psychosomatic Medicine
Hao Peng, Yun Zhu, Eric Strachan, Emily Fowler, Tamara Bacus, Peter Roy-Byrne, Jack Goldberg, Viola Vaccarino, Jinying Zhao
OBJECTIVE: DNA methylation has been associated with both early life stress and depression. This study examined the combined association of DNA methylation at multiple CpG probes in five stress-related genes with depressive symptoms, and tested whether these genes methylation mediated the association between childhood trauma and depression in two monozygotic (MZ) twin studies. METHODS: The current analysis comprised 119 MZ twin pairs (84 male pairs [mean 55 years], and 35 female pairs [mean 36 years])...
May 17, 2018: Psychosomatic Medicine
Carmen Vidal, Ruth Polo, Kiara Alvarez, Irene Falgas-Bague, Ye Wang, Benjamin Lê Cook, Margarita Alegría
OBJECTIVE: Trauma and/or symptoms of posttraumatic stress disorder (PTSD) have been linked to the onset of cardiovascular disease (CVD), but the exact mechanism has not been determined. We examine if the risk of CVD is different among those who have a history of trauma without PTSD symptoms, those who have experienced trauma and developed any symptoms of PTSD, and those with a PTSD diagnosis. Furthermore, we examine whether this association varies across ethnic/racial groups. METHODS: We used two datasets that form part of the Collaborative Psychiatric Epidemiology Surveys (CPES) - the National Latino and Asian American Study (NLAAS) and the National Comorbidity Survey Replication (NCS-R)...
May 17, 2018: Psychosomatic Medicine
Bryan W Kromenacker, Anna A Sanova, Frank I Marcus, John J B Allen, Richard D Lane
OBJECTIVE: Changes in heart rate variability (HRV) associated with breathing (respiratory sinus arrhythmia [RSA]) are known to be parasympathetically (vagally) mediated when the breathing rate is within the typical frequency range (9-24 breaths/min; high frequency HRV). Slow yogic breathing occurs at rates below this range and increases low frequency HRV power, which may additionally reflect a significant sympathetic component. Yogic breathing techniques are hypothesized to confer health benefits by increasing cardiac vagal control, but increases in low frequency HRV power cannot unambiguously distinguish sympathetic from parasympathetic contributions...
May 16, 2018: Psychosomatic Medicine
Natasha E Garcia-Willingham, Abbey R Roach, Edward J Kasarskis, Suzanne C Segerstrom
OBJECTIVE: Disease progression varies widely among patients with motor neuron disease (MND). Patients with MND and coexisting dementia have shorter survival. However, implications of mild cognitive and behavioral difficulties are unclear. The present study examined the relative contribution of executive functioning and self-regulation difficulties on survival over a 6-year period among patients with MND, who scored largely within normal limits on cognitive and behavioral indices. METHODS: Patients with MND (N=37, age=59...
May 16, 2018: Psychosomatic Medicine
Mandy X Hu, Femke Lamers, Melanie Neijts, Gonneke Willemsen, Eco J C de Geus, Brenda W J H Penninx
OBJECTIVE: Autonomic nervous system (ANS) imbalance has been cross-sectionally associated with inflammatory processes. Longitudinal studies are needed to shed light on the nature of this relationship. We examined cross-sectional and bidirectional prospective associations between cardiac autonomic measures and inflammatory markers. METHODS: Analyses were conducted with baseline (n=2823), 2-year (n=2099), and 6-year (n=1774) data from the Netherlands Study of Depression and Anxiety (NESDA)...
May 7, 2018: Psychosomatic Medicine
James A McCubbin, Aaron Nathan, Melissa A Hibdon, Anastasia M Castillo, Jack G Graham, Fred S Switzer
OBJECTIVE: Elevated resting blood pressure (BP) is associated with risk for hypertension and emotional dampening, including reduced responses to emotionally meaningful stimuli. Perception of threat is a critical motivator in avoidance of risky health-damaging behavior. We hypothesize that BP-associated dampening of threat appraisal may increase risk-taking behavior. METHODS: We measured resting BP, perception of affect, and risk behavior in 92 healthy, women (n=49) and men (n=43) recruited from university students and staff, and members of the surrounding community...
May 7, 2018: Psychosomatic Medicine
Pablo de la Coba, Stephen Bruehl, Carmen María Gálvez-Sánchez, Gustavo A Reyes Del Paso
OBJECTIVE: This study examined the diagnostic accuracy and test-retest reliability of a novel dynamic evoked pain protocol (slowly repeated evoked pain; SREP) compared to temporal summation of pain (TSP), a standard index of central sensitization. METHODS: Thirty-five fibromyalgia (FM) and 30 rheumatoid arthritis (RA) patients completed, in pseudorandomized order, a standard mechanical TSP protocol (10 stimuli of 1s duration at the thenar eminence using a 300g monofilament with 1s interstimulus interval) and the SREP protocol (9 suprathreshold pressure stimuli of 5s duration applied to the fingernail with a 30s interstimulus interval)...
May 1, 2018: Psychosomatic Medicine
Christoph Herrmann-Lingen, Thomas Meyer, Alexandra Bosbach, Mira L Chavanon, Lina Hassoun, Frank Edelmann, Rolf Wachter
OBJECTIVE: While diagnosed arterial hypertension and antihypertensive medication usually have an adverse impact on quality of life, recent studies suggest that actual blood pressure may be positively related to better well-being. However, data in older patients with cardiovascular risk factors are lacking, for whom such an association may be of particular relevance. METHODS: In 1,300 study participants with cardiovascular risk factors aged 50-85 years (51.5% men, mean age 65...
April 27, 2018: Psychosomatic Medicine
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