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Psychosomatic Medicine

Andrew W Manigault, Wilson S Figueroa, Cari R Hollenbeck, Anna E Mendlein, Alex Woody, Katrina R Hamilton, Matt C Scanlin, Ryan C Johnson, Peggy M Zoccola
OBJECTIVE: Revealing one's sexual identity to others is a complex process marked by a shift in the types of stressors faced by sexual minority young adults. Such stressors influence the secretion of health-relevant hormones, including cortisol, yet how dimensions of disclosure (i.e., the degree and context) influence neuroendocrine functioning remains poorly understood. The current study examined the association between disclosure context (disclosure to family members, friends/co-workers/acquaintances, and members of religious groups) and diurnal cortisol while allowing disclosure to vary in degree (i...
August 9, 2018: Psychosomatic Medicine
Johannes Peter, Camille Fournier, Marija Durdevic, Lukas Knoblich, Bettina Keip, Clemens Dejaco, Michael Trauner, Gabriele Moser
OBJECTIVE: Irritable bowel syndrome (IBS) is associated with alterations along the brain-gut-microbiota axis. Previous studies have suggested a parallel segregation of microbial features and psychological burden in IBS. This study aimed at exploring the microbial correlates of psychological distress in patients with IBS. METHODS: 48 patients with IBS (Rome-III criteria, age M (SD) 42 (15) years, 35 female, 25 diarrhea-dominant, 5 constipation-dominant and 18 alternating-type IBS) were assessed for psychological and clinical variables with validated questionnaires, faecal samples underwent microbial 16S rRNA analyses (regions V1-2)...
August 8, 2018: Psychosomatic Medicine
Alessio Maria Monteleone, Giuseppina Patriciello, Valeria Ruzzi, Giovanna Fico, Francesca Pellegrino, Giovanni Castellini, Luca Steardo, Palmiero Monteleone, Mario Maj
OBJECTIVE: Childhood attachment experiences affect adult emotion regulation and ability to cope with stressors. Therefore, insecure attachment may influence the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and a dysregulation of HPA axis has been found in insecure attached healthy individuals. The effects of attachment on HPA axis activity have never been investigated in eating disorders (EDs). Therefore, we assessed the relationships between insecure attachment and the cortisol awakening response (CAR) in adults with EDs...
August 6, 2018: Psychosomatic Medicine
Amanda C McClain, Rui S Xiao, Xiang Gao, Katherine L Tucker, Luis M Falcon, Josiemer Mattei
OBJECTIVE: Limited evidence demonstrates pathways linking food insecurity (FI) to chronic disease. Allostatic load (AL) may elucidate potential pathways, capturing both primary (neuroendocrine, inflammation) and secondary (metabolic, cardiovascular) physiological disturbances. We examined the longitudinal association of FI with 5-year AL and primary and secondary sub-system dysregulation, and tested moderation by Supplemental Nutrition Assistance Program (SNAP) participation. METHODS: We analyzed data from the longitudinal Boston Puerto Rican Health Study among 733 adults aged 45-75y...
July 24, 2018: Psychosomatic Medicine
Thomas W Kamarck, Xingyuan Li, Aidan G C Wright, Matthew F Muldoon, Stephen B Manuck
OBJECTIVE: We examined whether associations between daily psychosocial stressor exposures and carotid artery intima medial thickness (IMT) may be stronger among those showing larger stress-related cardiovascular reactivity (CVR) during the course of daily living. METHODS: 474 healthy working adults (ages 30-54) collected ambulatory blood pressure (ABP) and recorded their daily experiences, using electronic diaries, during two 2-day periods over the course of a week...
July 16, 2018: Psychosomatic Medicine
Deokjong Lee, Se Joo Kim, Jooah Cheon, Eun Hee Hwang, Young-Chul Jung, Jee In Kang
OBJECTIVE: Altered autonomic nervous system activity is considered to be involved in the pathophysiology of somatic symptom disorder (SSD). This study aimed to investigate whether patients with SSD have disturbed autonomic activity during rest and reactivity to emotional processing and whether altered autonomic nervous system correlates with clinical characteristics and interoceptive accuracy in SSD. METHODS: We recruited 23 patients with SSD and 20 healthy controls...
July 9, 2018: Psychosomatic Medicine
Daniel Beis, Roland von Känel, Nadja Heimgartner, Claudia Zuccarella-Hackl, Alexander Bürkle, Ulrike Ehlert, Petra H Wirtz
OBJECTIVE: Acute stress induces redistribution of circulating leucocytes in humans. Whereas effects on lymphocytes as adaptive immune cells are well-understood, the mechanisms underlying stress effects on granulocytes and monocytes as innate immune blood cells are still elusive. We investigated whether the stress hormone norepinephrine (NE) and α-adrenergic receptors (α-ADRs) may play a mediating role. METHODS: In a stress study, we cross-sectionally tested in 44 healthy men for associations between stress-induced NE increases and simultaneous granulocyte and monocyte cell count increases, as measured immediately before and several times after the Trier Social Stress Test...
June 29, 2018: Psychosomatic Medicine
Sirak Z Gebreab, Caroline L Vandeleur, Dominique Rudaz, Marie-Pierre F Strippoli, Mehdi Gholam-Rezaee, Enrique Castelao, Aurélie M Lasserre, Jennifer Glaus, Giorgio Pistis, Christine Kuehner, Roland von Känel, Pedro Marques-Vidal, Peter Vollenweider, Martin Preisig
OBJECTIVE: The complex relationship between psychosocial stress over the lifetime, psychological factors, and cardio-metabolic risk is still poorly understood. Accordingly, our aims were 1) to independently assess the associations between childhood adversity, life-event stress in remote (earlier than the last 5 years) and recent adulthood and cardio-metabolic risk, and 2) to determine the role of psychological factors including personality, coping and depression in these associations...
June 29, 2018: Psychosomatic Medicine
Åsa Askim, Lise Tuset Gustad, Julie Paulsen, Solveig Klæbo Reitan, Arne Mehl, Randi Marie Mohus, Andrew Dewan, Jan Kristian Damås, Erik Solligård, Bjørn Olav Åsvold
OBJECTIVE: We examined whether anxiety and depression symptoms constitute increased risk of bloodstream infection (BSI), as a proxy for sepsis. METHODS: A general population with self-reported anxiety and depression symptoms was followed prospectively for hospital-verified BSI. Using multivariable Cox regression analysis, we estimated hazard ratios (HR) with 95% confidence intervals (CI) of BSI and BSI mortality, with and without statistical adjustment for comorbidities, BMI and lifestyle factors that may confound or mediate the associations...
June 19, 2018: Psychosomatic Medicine
Sarah C E Stanton, Emre Selcuk, Allison K Farrell, Richard B Slatcher, Anthony D Ong
OBJECTIVE: This study tested longitudinal associations between absolute levels of perceived partner responsiveness (PPR; how much people feel their romantic partners understand, care for, and appreciate them), daily negative affect (NA) reactivity and positive affect (PA) reactivity, and all-cause mortality in a sample of 1,208 adults over three waves of data collection spanning 20 years. We also tested whether longitudinal changes in PPR predicted mortality via affect reactivity. METHODS: Data were taken from the National Survey of Midlife Development in the United States (MIDUS)...
June 18, 2018: Psychosomatic Medicine
Ashley E Mason, Frederick M Hecht, Jennifer J Daubenmier, David A Sbarra, Jue Lin, Patricia J Moran, Samantha G Schleicher, Michael Acree, Aric A Prather, Elissa S Epel
OBJECTIVE: To determine, within a weight-loss clinical trial for obesity, the impact of intervention arm, weight change, and weight-loss maintenance on telomere length (TL). METHODS: Adults (N=194) with a BMI between 30 and 45 were randomized to a 5.5-month weight-loss program with (n=100) or without (n=94) mindfulness training and identical diet-exercise guidelines. We assessed TL at baseline and 3, 6, and 12 months post-baseline in immune cell populations (primarily in peripheral blood mononuclear cells [PBMCs], but also in granulocytes and T and B lymphocytes)...
June 12, 2018: Psychosomatic Medicine
Tiffany L Carson, Fuchenchu Wang, Xiangqin Cui, Bradford E Jackson, William J Van Der Pol, Elliot J Lefkowitz, Casey Morrow, Monica L Baskin
OBJECTIVE: Racial health disparities persist among black and white women for colorectal cancer. Understanding racial differences in the gut microbiota and related covariates (e.g., stress) may yield new insight into unexplained colorectal cancer disparities. METHODS: Healthy non-Hispanic black or white females (age ≥19 years) provided survey data, anthropometrics, and stool samples. Fecal DNA was collected and isolated from a wipe. PCR was used to amplify the V4 region of the 16SrRNA gene and 250 bases were sequenced using the MiSeq platform...
June 12, 2018: Psychosomatic Medicine
Laura Ricarda Koenen, Adriane Icenhour, Katarina Forkmann, Nina Theysohn, Michael Forsting, Ulrike Bingel, Sigrid Elsenbruch
OBJECTIVE: The aim of this study was to compare behavioral and neural anticipatory responses to cues predicting either somatic or visceral pain in an associative learning paradigm. METHODS: Healthy women (N=22) underwent functional magnetic resonance imaging. During an acquisition phase, two different visual cues repeatedly signaled either experimental visceral or somatic pain. In a subsequent extinction phase, identical cues were presented without pain. Before and after each phase, cue valence and contingency awareness were assessed on visual analogue scales...
June 4, 2018: Psychosomatic Medicine
Yannick Stephan, Angelina R Sutin, Antonio Terracciano
OBJECTIVE: Subjective age has been implicated in a range of health outcomes. The present study extends existing research by providing new data on the relation between subjective age and mortality in three large national samples. METHODS: Participants (total N > 17,000) were drawn from the Health and Retirement Study (HRS, 2008-2014), the Midlife in the United State Survey (MIDUS, 1995-2014), and the National Health and Aging Trends Study (NHATS, 2011-2014). Subjective age, demographic factors, disease burden, functional limitations, depressive symptoms, and physical inactivity were assessed at baseline and mortality data were tracked for up to 20 years...
June 1, 2018: Psychosomatic Medicine
Kalina J Michalska, Julia S Feldman, Rany Abend, Andrea L Gold, Troy C Dildine, Esther E Palacios-Barrios, Ellen Leibenluft, Kenneth E Towbin, Daniel S Pine, Lauren Y Atlas
OBJECTIVE: Naturalistic studies suggest that expectation of adverse experiences such as pain exerts particularly strong effects on anxious youth. In healthy adults, expectation influences the experience of pain. The current study uses experimental methods to compare the effects of expectation on pain among adults, healthy youth, and youth with an anxiety disorder. METHODS: Twenty-three healthy adults, 20 healthy youth, and 20 youth with an anxiety disorder underwent procedures in which auditory cues were paired with noxious thermal stimulation...
May 30, 2018: Psychosomatic Medicine
Marina López-Solà, Leonie Koban, Tor D Wager
OBJECTIVES: Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here we test a novel meaning-based intervention: Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a positive, prosocial meaning context. We predicted that the ventromedial prefrontal cortex (vmPFC), a key structure for pain regulation and generation of affective meaning, would mediate the transformation of pain experience by this prosocial interpersonal context...
May 24, 2018: Psychosomatic Medicine
Keith M Diaz, Anusorn Thanataveerat, Faith E Parsons, Sunmoo Yoon, Ying Kuen Cheung, Carmela Alcantara, Andrea T Duran, Ipek Ensari, David J Krupka, Joseph E Schwartz, Matthew M Burg, Karina W Davidson
OBJECTIVES: The purpose of this study, which used mobile technologies to continuously collect data over 1 year, was to examine the association of psychological stress with objectively measured sedentary behavior in adults at both the group (e.g. nomothetic approach) and individual (e.g. idiographic approach) level. METHODS: Data were collected in an observational study of healthy adults (n=79) residing in the New York City metro area who were studied for 365 days from 2014-2015...
May 24, 2018: Psychosomatic Medicine
Stefano Magon, Till Sprenger, Alexander Otti, Athina Papadopoulou, Harald Gündel, Michael Noll-Hussong
OBJECTIVE: Chronic pain disorder (CPD) has been associated with brain changes, especially in limbic circuits. However, in the majority of patients with chronic pain, depression or anxiety are common comorbidities. In this exploratory and naturalistic study, we investigated brain cortical thickness differences between patients with CPD and healthy controls, with consideration of concurrent psychiatric symptoms. METHODS: Twenty-three patients with CPD and 23 age- and sex-matched healthy volunteers were included in this study...
May 21, 2018: Psychosomatic Medicine
Hao Peng, Yun Zhu, Eric Strachan, Emily Fowler, Tamara Bacus, Peter Roy-Byrne, Jack Goldberg, Viola Vaccarino, Jinying Zhao
OBJECTIVE: DNA methylation has been associated with both early life stress and depression. This study examined the combined association of DNA methylation at multiple CpG probes in five stress-related genes with depressive symptoms, and tested whether these genes methylation mediated the association between childhood trauma and depression in two monozygotic (MZ) twin studies. METHODS: The current analysis comprised 119 MZ twin pairs (84 male pairs [mean 55 years], and 35 female pairs [mean 36 years])...
May 17, 2018: Psychosomatic Medicine
Carmen Vidal, Ruth Polo, Kiara Alvarez, Irene Falgas-Bague, Ye Wang, Benjamin Lê Cook, Margarita Alegría
OBJECTIVE: Trauma and/or symptoms of posttraumatic stress disorder (PTSD) have been linked to the onset of cardiovascular disease (CVD), but the exact mechanism has not been determined. We examine if the risk of CVD is different among those who have a history of trauma without PTSD symptoms, those who have experienced trauma and developed any symptoms of PTSD, and those with a PTSD diagnosis. Furthermore, we examine whether this association varies across ethnic/racial groups. METHODS: We used two datasets that form part of the Collaborative Psychiatric Epidemiology Surveys (CPES) - the National Latino and Asian American Study (NLAAS) and the National Comorbidity Survey Replication (NCS-R)...
May 17, 2018: Psychosomatic Medicine
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