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Progress in Cardiovascular Diseases

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https://www.readbyqxmd.com/read/30107184/management-of-heart-failure-in-adult-congenital-heart-disease
#1
REVIEW
Angeline D Opina, Wayne J Franklin
Heart failure (HF) in the adult with congenital heart disease (ACHD) is associated with high morbidity and mortality and has been implicated as the leading cause of death in this patient population. The diagnosis of HF in ACHD involves a combination of clinical suspicion from subjective patient history, anatomic imaging, functional diagnostic studies, and rhythm evaluation. Once diagnosed, the approach to management of HF in this population varies widely and by lesion. Unfortunately, there is a paucity of literature available delineating the optimal management of these patients, making clinical decision-making extremely challenging...
August 11, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30102921/family-planning-and-pregnancy-management-in-adults-with-congenital-heart-disease
#2
REVIEW
Kelly K Shum K, Tripti Gupta T, Mary Canobbio, Jennifer Durst, Sangeeta B Shah
With advances in congenital heart disease management, there are an increasing number of women reaching reproductive age. Pregnancy results in a surge of hormones and increased demands on both the cardiovascular (CV) and respiratory systems. Depending on the heart defect and the treatments the mother has undergone, these hemodynamic changes can result in an increased risk of maternal CV events and an increased risk of fetal morbidity and mortality. Thus, it is important to have a comprehensive approach to adult congenital heart disease patients involving pre-pregnancy planning in addition to diligent peri- and post-partum care...
August 10, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30041022/when-the-heart-is-not-to-blame-managing-lung-disease-in-adult-congenital-heart-disease
#3
REVIEW
Salil Ginde, Michael G Earing
It is well-recognized now that adult survivors with congenital heart disease (CHD) are at risk for non-cardiac co-morbidities and complications that can impact symptoms and clinical outcomes. Lung disease, in particular, is common in this population, but likely an under-recognized and undertreated cause for long-term morbidity. Abnormal lung function contributes to exercise intolerance and is associated with a higher risk for mortality in this population. The exact mechanisms that contribute to abnormal measurements of lung function are not entirely known, and are likely multifactorial and variable depending on the underlying CHD...
July 21, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30041021/precise-therapy-for-thoracic-aortic-aneurysm-in-marfan-syndrome-a-puzzle-nearing-its-solution
#4
REVIEW
Erica Rurali, Gianluca Lorenzo Perrucci, Chiara Assunta Pilato, Alessandro Pini, Raffaella Gaetano, Patrizia Nigro, Giulio Pompilio
Marfan Syndrome (MFS) is a rare connective tissue disorder, resulting from mutations in the fibrillin-1 gene, characterized by pathologic phenotypes in multiple organs, the most detrimental of which affects the thoracic aorta. Indeed, thoracic aortic aneurysms (TAA), leading to acute dissection and rupture, are today the major cause of morbidity and mortality in adult MFS patients. Therefore, there is a compelling need for novel therapeutic strategies to delay TAA progression and counteract aortic dissection occurrence...
July 21, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30041020/coronary-disease-and-modifying-cardiovascular-risk-in-adult-congenital-heart-disease-patients-should-general-guidelines-apply
#5
REVIEW
Jordan D Awerbach, Richard A Krasuski, Michael G W Camitta
There are >1.4 million adult congenital heart disease (CHD; ACHD) patients living in the United States. Coronary artery disease (CAD) is at least as prevalent in ACHD patients as in the general population and has become a leading cause of their mortality. In the majority of cases, CAD in the ACHD population is driven by the presence of traditional cardiovascular disease (CVD) risk factors. 80% of ACHD patients have at least one CVD risk factor. Hypertension (HTN), obesity and physical inactivity are frequently seen in both pediatric and adult patients with CHD...
July 21, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30012407/depressive-and-anxiety-symptoms-in-adult-congenital-heart-disease-prevalence-health-impact-and-treatment
#6
REVIEW
Jamie L Jackson, Carine E Leslie, Shawn N Hondorp
Over 1.4 million adults in the United States are living with congenital heart disease (CHD), which can vary widely in disease burden and risk for future cardiovascular complications. As a result, some CHD survivors may experience greater emotional distress, including symptoms of depression and anxiety. This review summarizes the developing research literature on the prevalence, health impact, as well as screening and treatment of depressive and anxiety symptoms among adult CHD survivors. Additionally, the review will highlight findings from the acquired heart disease literature, a well-studied area that can inform research and clinical care practices for CHD survivors with depressive and/or anxiety symptoms...
July 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30031004/transition-of-care-in-congenital-disease-allaying-fears-for-patients-and-specialists
#7
REVIEW
Timothy B Cotts
Advances in the care of infants and children with congenital heart disease (CHD) have resulted in significantly improved survival of this population into adulthood. Although the majority of patients with CHD have undergone surgical intervention or transcatheter intervention, patients are not "cured" and almost all require lifelong cardiac care. In many parts of the world, robust systems of care have been developed for infants and children with CHD. Although there has been progress in the development of programs for the care of adults with CHD, the time of transition and transfer of care remains a time of high risk for lapses in care and becoming lost to follow-up...
July 18, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30031003/a-multifaceted-approach-to-pulmonary-hypertension-in-adults-with-congenital-heart-disease
#8
REVIEW
Mouhammad Fathallah, Richard A Krasuski
Advances in the management of congenital heart disease (CHD) in children have resulted in growing numbers of adults with CHD. Pulmonary arterial hypertension related to CHD (PAH-CHD) is a common complication, affecting up to 10% of patients; and can arise even after successful and complete defect repair, with severe and potentially fatal consequences. Careful work-up in these patients is essential, particularly hemodynamic assessment, and can help define the most appropriate therapeutic approach. Management can be challenging, but the therapeutic armamentarium is continually expanding and now includes surgical, transcatheter and medical options...
July 18, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/30003901/the-effects-of-exercise-and-physical-activity-on-weight-loss-and-maintenance
#9
REVIEW
Damon L Swift, Joshua E McGee, Conrad P Earnest, Erica Carlisle, Madison Nygard, Neil M Johannsen
Obesity represents a major health problem in the United States and is associated with increased prevalence of cardiovascular (CV) disease risk factors. Physical activity (PA) and exercise training (ET) are associated with reduced CV risk, improved cardiometabolic risk factors, and facilitated weight loss through creating a negative energy balance. Clinicians need to counsel overweight and obese patients on how much PA/ET is needed to promote weight loss and weight loss maintenance. This will help establish realistic expectations and maximize improvements in CV risk factors...
July 9, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29990534/obesity-paradox-in-aging-from-prevalence-to-pathophysiology
#10
REVIEW
Shuyi Wang, Jun Ren
Recent advances in medical technology and health care have greatly improved the management for chronic diseases and prolonged human lifespan. Unfortunately, increased lifespan and the aging population impose a major challenge on the ever-rising prevalence of chronic diseases, in particular cardiometabolic stress associated with the pandemic obesity in our modern society. Although overweight and obesity are associated with incident cardiovascular diseases (CVD), including heart failure (HF), it paradoxically leads to a more favorable prognosis in patients with chronic HF, a phenomenon commonly defined as "obesity paradox"...
July 7, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29990533/obesity-and-cardiac-remodeling-in-adults-mechanisms-and-clinical-implications
#11
REVIEW
Martin A Alpert, Kamalesh Karthikeyan, Obai Abdullah, Rugheed Ghadban
Obesity, particularly severe obesity is capable of producing hemodynamic alterations that contribute to changes in cardiac morphology which may predispose to impairment of ventricular function and heart failure. These include a high cardiac output state in most, left ventricular (LV) hypertrophy, and LV diastolic dysfunction. Right heart involvement may result from LV failure, the hypercirculatiory state, and sleep disordered breathing. In recent years experimental studies and some studies in humans suggest that certain neurohormonal and metabolic alterations that occur commonly in obesity may contribute to alterations in cardiac structure and function...
July 7, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29981771/an-overview-and-update-on-obesity-and-the-obesity-paradox-in-cardiovascular-diseases
#12
REVIEW
Andrew Elagizi, Sergey Kachur, Carl J Lavie, Salvatore Carbone, Ambarish Pandey, Francisco Ortega, Richard V Milani
Obesity increases a number of cardiovascular disease (CVD) risk factors, but patients with many types of CVD may have a better prognosis if classified as overweight or obese, a phenomenon known as the "obesity paradox". This paradoxical benefit of a medically unfavorable phenotype is particularly strong in the overweight and class I obesity, and less pronounced in the more severe or morbidly obese populations (class II-III and greater). Rather than an obesity paradox, it is possible that this phenomenon may represent a "lean paradox", in which individuals classified as normal weight or underweight may have a poorer prognosis with respect to CVD, as a result of a progressive catabolic state and lean mass loss...
July 5, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29981352/the-joint-association-of-fitness-and-fatness-on-cardiovascular-disease-mortality-a-meta-analysis
#13
REVIEW
Vaughn W Barry, Jennifer L Caputo, Minsoo Kang
The joint association of cardiorespiratory fitness (CRF) and body mass index (BMI) on cardiovascular disease (CVD) mortality was determined. PubMed and CINAHL were searched following PRISMA guidelines. Included studies were prospective, had objective assessments of maximal CRF and BMI, and compared the joint impact of CRF and BMI on CVD mortality risk to normal weight, fit referents. Pooled hazard ratios and 95% confidence intervals were calculated from eight articles with nine independent groups using a random effects model...
July 5, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29981350/obesity-and-kidney-disease
#14
REVIEW
Jay I Lakkis, Mathew R Weir
Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages. Clinically, the obesity phenotype is not homogenous and is more likely to represent a spectrum with varying degrees of metabolic un-health; metabolically-unhealthy obesity is often a part of the metabolic syndrome...
July 5, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29981353/special-editor-s-page-the-fluctuating-journal-statistics
#15
EDITORIAL
Carl J Lavie
No abstract text is available yet for this article.
July 4, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29981351/role-of-human-brown-fat-in-obesity-metabolism-and-cardiovascular-disease-strategies-to-turn-up-the-heat
#16
REVIEW
Jonatan R Ruiz, Borja Martinez-Tellez, Guillermo Sanchez-Delgado, Francisco J Osuna-Prieto, Patrick C N Rensen, Mariëtte R Boon
Human brown adipose tissue (BAT) was re-discovered in 2009 by several independent groups, who showed that it is present and active in adults, as judged from the profound uptake of the glucose analogue radiotracer 18 F-fluorodeoxyglucose in positron-emission tomography and computed tomography scan analysis after cold exposure. A potential clinical implication of activating BAT relates to its high metabolic activity and its potential role in stimulating energy expenditure (i.e. resting energy expenditure, meal-induced thermogenesis, and cold-induced thermogenesis), which makes it an attractive target to reduce adiposity...
July 4, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29981349/introduction-and-update-on-obesity-and-cardiovascular-diseases-2018
#17
EDITORIAL
Francisco B Ortega, Carl J Lavie
No abstract text is available yet for this article.
July 4, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29981348/obesity-paradox-in-advanced-kidney-disease-from-bedside-to-the-bench
#18
REVIEW
Neda Naderi, Carola-Ellen Kleine, Christina Park, Jui-Ting Hsiung, Melissa Soohoo, Ekamol Tantisattamo, Elani Streja, Kamyar Kalantar-Zadeh, Hamid Moradi
While obesity is associated with a variety of complications including diabetes, hypertension, cardiovascular disease and premature death, observational studies have also found that obesity and increasing body mass index (BMI) can be linked with improved survival in certain patient populations, including those with conditions marked by protein-energy wasting and dysmetabolism that ultimately lead to cachexia. The latter observations have been reported in various clinical settings including end-stage renal disease (ESRD) and have been described as the "obesity paradox" or "reverse epidemiology", engendering controversy...
July 4, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29964067/overview-of-epidemiology-and-contribution-of-obesity-and-body-fat-distribution-to-cardiovascular-disease-an-update
#19
REVIEW
Marie-Eve Piché, Paul Poirier, Isabelle Lemieux, Jean-Pierre Després
Obesity is recognized as a heterogeneous condition in which individuals with similar body mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to obesity-related cardiometabolic complications is not solely mediated by overall body fat mass, but is largely dependent upon individual differences in regional body fat distribution and ability of subcutaneous adipose tissue to expand. The present review will discuss to what extent the individual variation in body fat distribution is one of the clinical key variables explaining the metabolic heterogeneity of obesity and its related cardiovascular risk...
June 28, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29953878/metabolic-and-bariatric-surgery-an-effective-treatment-option-for-obesity-and-cardiovascular-disease
#20
REVIEW
Wayne J English, D Brandon Williams
Obesity is a chronic and debilitating disease that has become a global epidemic. Especially severe in the Unites States, obesity currently affects almost 40% of the population. Obesity has a strong causal relationship with numerous serious comorbidities that impair quality of life, shorten life expectancy, and carry a major economic burden. Obesity has particular relevance to cardiologists because it contributes directly to several major cardiovascular diseases and, consequently, increases overall cardiovascular mortality...
June 25, 2018: Progress in Cardiovascular Diseases
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