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Progress in Cardiovascular Diseases

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https://www.readbyqxmd.com/read/29225114/fructose-induced-inflammation-and-increased-cortisol-a-new-mechanism-for-how-sugar-induces-visceral-adiposity
#1
REVIEW
James J DiNicolantonio, Varshil Mehta, Neema Onkaramurthy, James H O'Keefe
Traditionally, the leading hypothesis regarding the development of obesity involves caloric imbalance, whereby the amount of calories consumed exceeds the amount of calories burned which causes obesity. Another hypothesis for why we get fat has surfaced in the last decade which is the idea that the overconsumption of added sugars and refined carbohydrates induce insulin resistance and high insulin levels causing obesity. While insulin is a fat-storing hormone, this hypothesis does not explain visceral adiposity, or why certain people are found to have fat stored in and around their organs...
December 7, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29196230/functional-anatomy-and-pathophysiologic-principles-in-mitral-regurgitation-non-invasive-assessment
#2
REVIEW
Sylvestre Maréchaux, Jeffery E Illman, James Huynh, Hector I Michelena, Vuyisile T Nkomo, Christophe Tribouilloy
Mitral regurgitation (MR) is the most prevalent cause of valvular heart disease (VHD) in western countries. In the Euro Heart Survey on VHD, MR was the second most common heart VHD requiring surgery. It is also the most common form of VHD in community and population-based studies from the United States. The categorization of MR based on causes and mechanisms is a major determinant of clinical outcome, of possible therapies for the MR and of the effectiveness of these therapies. Surgical mitral valve (MV) repair has been shown to improve survival in patients with severe primary MR compared with MV replacement...
November 28, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29174559/assessment-of-the-severity-of-native-mitral-valve-regurgitation
#3
REVIEW
Kinan Carlos El-Tallawi, David Messika Zeitoun, William A Zoghbi
Mitral regurgitation (MR) is a major cause of cardiovascular morbidity and mortality. MR is classified as primary (organic) if it is due to an intrinsic valve abnormality, or secondary (functional) if the etiology is because of remodeling of left ventricular geometry and/or valve annulus. Transthoracic echocardiography (TTE) is the initial modality for MR evaluation. Parameters used for the assessment of MR include valve structure, cardiac remodeling, and color and spectral Doppler. Quantitative measurements include effective regurgitant orifice area, regurgitant volume, and regurgitant fraction...
November 21, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29162536/functional-mitral-regurgitation-imaging-insights-clinical-outcomes-and-surgical-principles
#4
REVIEW
Nozomi Watanabe, Simon Maltais, Shun Nishino, Tara A O'Donoghue, Judy Hung
Functional mitral regurgitation (MR;FMR) is the most common type of MR and its development is associated with increased morbidity and mortality. Leaflet tethering with apical shift of the papillary muscle due to adverse left ventricular remodeling and loss of normal leaflet coaptation is the principal mechanism of FMR. Echocardiography plays a central role in the assessment of the FMR. The development of 3D echocardiography has allowed for assessment of the geometric changes of mitral valve morphology and spatial relationship with the left ventricle that accompanies FMR...
November 18, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29158077/mitral-regurgitation-in-the-21-st-century
#5
EDITORIAL
Maurice Enriquez-Sarano, Hector I Michelena
No abstract text is available yet for this article.
November 17, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29154956/biomarkers-in-mitral-regurgitation
#6
REVIEW
Magnus Bäck, Rodolfo Pizarro, Marie-Annick Clavel
Mitral regurgitation (MR) is a common cause of heart failure but may also remain silent without either symptoms or altered cardiac function. In the latter case, management is still controversial and biomarkers could be an important means to solving remaining issues in MR management. As objective markers of myocardial stress and early left ventricular dysfunction, biomarkers may for example facilitate the identification of patients with benefit from early surgery of degenerative MR. The most studied biomarkers are the natriuretic peptides (NPs), especially brain NP, as well as its N terminal prohormone...
November 16, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29133070/percutaneous-treatment-for-native-mitral-regurgitation
#7
REVIEW
Paul Sorajja, Francesco Maisano
Severe mitral regurgitation (MR) confers an adverse prognosis, frequently with debilitating symptoms of heart failure. While open surgical correction has been the standard of care for decades, novel catheter-based technologies have emerged that are highly effective in the treatment of MR. These percutaneous technologies, which include methods for both repair as well as valve replacement, have the potential to address unmet clinical needs in patients with MR, and serve as a viable alternative to surgery.
November 10, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29128572/mitral-valve-repair-robotic-and-other-minimally-invasive-approaches
#8
REVIEW
Mateo Marin Cuartas, Hoda Javadikasgari, Bettina Pfannmueller, Joerg Seeburger, A Marc Gillinov, Rakesh M Suri, Michael A Borger
Robotic and minimally invasive mitral valve (MV) procedures have been performed with increasing frequency over time. These alternatives offer similar efficacy to that achieved via standard median sternotomy, particularly in large volume centers, along with low perioperative morbidity and mortality rates. Moreover, patient acceptance is oftentimes increased due to less postoperative pain and shorter recovery times, as well as superior cosmetic results. However, these techniques are technically complex and associated with a significant learning curve...
November 8, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29128571/exercise-testing-in-mitral-regurgitation
#9
REVIEW
Raluca Dulgheru, Stella Marchetta, Tadafumi Sugimoto, Yun Yun Go, Alexandra Girbea, Oury Cécile, Patrizio Lancellotti
Mitral regurgitation (MR) is the second most common valvular heart disease referred for corrective surgery. Diagnostic and management dilemmas are not uncommon when dealing with MR patients. Exercise testing plays an important role in sorting out some of these clinical challenges. In primary asymptomatic MR, exercise testing allows symptom assessment, confident link of symptoms to valve disease severity, safe deferral of surgery for the next 1-year in patients with preserved exercise capacity, insights into the mechanism of exercise-induced dyspnea and helps in individual risk stratification...
November 8, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29128570/outcomes-in-degenerative-mitral-regurgitation-current-state-of-the-art-and-future-directions
#10
REVIEW
Milind Y Desai, Francesco Grigioni, Marco Di Eusanio, Matteo Saccocci, Maurizio Taramasso, Francesco Maisano, Rakesh M Suri, A Marc Gillinov
Mitral regurgitation (MR) is the one of the most frequent valvular heart diseases in the developed world, often requiring surgical correction. Degenerative MR is the most common type of non-ischemic, organic MR in the western world. Since no medical treatment has been shown to be effective in preventing the consequences of volume overload in asymptomatic degenerative MR, risk stratification is essential. Currently, this is achieved using clinical and precisely quantified echocardiographic parameters, with newer technologies like cardiac magnetic resonance gaining increasing prominence...
November 8, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29122631/mitral-valve-prolapse-multimodality-imaging-and-genetic-insights
#11
REVIEW
Purvi Parwani, Jean-Francois Avierinos, Robert A Levine, Francesca Nesta Delling
Mitral valve prolapse (MVP) is a common heritable valvulopathy affecting approximately 2.4% of the population. It is the most important cause of primary mitral regurgitation (MR) requiring surgery. MVP is characterized by fibromyxomatous changes and displacement of one or both mitral leaflets into the left atrium. Echocardiography represents the primary diagnostic modality for assessment of MVP. Accurate quantitation of ventricular volumes and function for surgical planning in asymptomatic severe MR can be provided with both echocardiography and cardiac magnetic resonance ...
November 6, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29122630/special-editor-s-page-four-years-as-editor-in-chief
#12
EDITORIAL
Carl J Lavie
No abstract text is available yet for this article.
November 6, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29117502/mitral-valve-repair-in-degenerative-mitral-regurgitation-state-of-the-art
#13
REVIEW
Michele De Bonis, Ottavio Alfieri, Malcolm Dalrymple-Hay, Benedetto Del Forno, Filip Dulguerov, Gilles Dreyfus
In industrialized countries, the most common etiology of mitral regurgitation (MR) is degenerative mitral valve (MV) disease. The natural history of severe degenerative MR is poor. However, its appropriate and timely correction is associated with a life expectancy similar to that of the normal population. Surgical MV repair is the gold standard treatment. This review will focus on the most recent evidence with a specific emphasis on surgical indications, timing of treatment, contemporary surgical techniques, Heart Teams and Centers of Excellence...
November 5, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29117501/mitral-valve-in-valve-ring-and-other-percutaneous-treatments-of-surgical-failures
#14
REVIEW
Mackram F Eleid
Re-do mitral valve surgery is associated with high morbidity and mortality. In recent years a variety of percutaneous repair techniques of surgical failures have emerged as safe and effective treatment options for several post-surgical problems including bioprosthetic mitral valve failure, prosthetic regurgitation or stenosis following annuloplasty, and periprosthetic regurgitation. This review will cover the indications, techniques and outcomes of these novel percutaneous therapies.
November 5, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29108929/development-of-a-new-ict-based-multisensor-blood-pressure-monitoring-system-for-use-in-hemodynamic-biomarker-initiated-anticipation-medicine-for-cardiovascular-disease-the-national-impact-program-project
#15
REVIEW
Kazuomi Kario, Naoko Tomitani, Hiroshi Kanegae, Nobuhiko Yasui, Masafumi Nishizawa, Takeshi Fujiwara, Takeya Shigezumi, Ryozo Nagai, Hiroshi Harada
We have developed a multisensor home and ambulatory blood pressure (BP) monitoring system for monitoring 24-hr central and brachial BP variability concurrent with physical activity (PA), temperature, and atmospheric pressure. The new BP monitoring system utilizes our recently developed biological and environmental signal monitoring Information Communication Technology/Internet of Things system, which can simultaneously monitor the environment (temperature, illumination, etc.) of different rooms in a house (entryway, bedroom, living room, bathing room, and toilet), and a wrist-type high-sensitivity actigraph for identifying the location of patients...
November 3, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29104119/community-based-healthy-living-medicine-with-a-focus-on-k-12-physical-education-and-nutrition
#16
REVIEW
Sally S Wong
Childhood obesity is one of the country's most significant health problems. Researchers estimate that 32.2% of children and adolescents ages 2 to 19 in the United States are overweight and obese. The prevalence of childhood obesity in 2011-2014 was 17.0% and extreme obesity was 5.8% among US children and adolescents aged 2 to 19 years. The high rates of obesity and diabetes, poor nutrition, and lack of physical activity in children and adolescents makes cardiovascular risk reduction in this population critical...
November 2, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29056395/3d-transesophageal-echocardiography-a-new-imaging-tool-for-assessment-of-mitral-regurgitation-and-for-guiding-percutaneous-edge-to-edge-mitral-valve-repair
#17
REVIEW
Francesco F Faletra, Alain Berrebi, Giovanni Pedrazzini, Laura Anna Leo, V L Paiocch, G Cautilli, Gabriele Casso, Tiziano Cassina, Tiziano Moccetti, Joseph F Malouf
Real time three dimensional transesophageal echocardiography (3D TEE) is probably the most powerful and convincing imaging method for understanding the complicated multiform morphology and for evaluating geometry, dynamics and function of degenerative and functional mitral valve (MV) regurgitation. Moreover, color Doppler 3D TEE has been valuable to identify the location of the regurgitant orifice and the severity of the mitral regurgitation. 3D TEE has been shown to be of enormous value in helping surgeons to perform MV repair...
October 19, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28958751/insulin-therapy-increases-cardiovascular-risk-time-for-a-sea-of-change-in-type-2-diabetes-treatment
#18
REVIEW
Mary E Herman, James H O'Keefe, David S H Bell, Stanley S Schwartz
Insulin therapy increased cardiovascular (CV) risk and mortality among type 2 diabetes (T2D) patients in several recently reported clinical outcomes trials. To assess whether this association is causative or coincidental, PubMed searches were used to query the effects of insulin therapy for T2D on CV health and longevity from large-scale outcomes trials, meta-analyses, and patient registry studies, as well as basic research on insulin's direct and pleiotropic actions. Although several old studies provided conflicting results, the majority of large observational studies show strong dose-dependent associations for injected insulin with increased CV risk and worsened mortality...
September 25, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28865801/approach-to-acute-heart-failure-in-the-emergency-department
#19
REVIEW
Benton R Hunter, Jennifer Martindale, Osama Abdel-Hafez, Peter S Pang
Acute heart failure (AHF) patients rarely present complaining of 'acute heart failure.' Rather, they initially present to the emergency department (ED) with a myriad of chief complaints, symptoms, and physical exam findings. Such heterogeneity prompts an initially broad differential diagnosis; securing the correct diagnosis can be challenging. Although AHF may be the ultimate diagnosis, the precipitant of decompensation must also be sought and addressed. For those AHF patients who present in respiratory or circulatory failure requiring immediate stabilization, treatment begins even while the diagnosis is uncertain...
September 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28847619/pharmacologic-therapy-for-heart-failure-with-reduced-ejection-fraction-closing-the-gap-between-clinical-guidelines-and-practice
#20
REVIEW
J Barr Biglane, Miriam F Becnel, Hector O Ventura, Selim R Krim
Despite the great progress made in the management of heart failure (HF) with reduced ejection fraction (HFrEF), its prevalence continues to rise owing to an aging population and an epidemic of hypertension, obesity and coronary artery disease. For decades, angiotensin converting enzyme inhibitors and beta blockers have been the mainstay of HFrEF therapy. The recent addition of sacubitril/valsartan and ivabradine to the HF armamentarium has the potential to transform our therapeutic approach to HFrEF, while simultaneously raising some questions and uncertainties on their applicability...
September 2017: Progress in Cardiovascular Diseases
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