journal
https://read.qxmd.com/read/38533776/comparison-of-red-and-green-light-for-treating-non-muscle-invasive-bladder-cancer-in-rats-using-singlet-oxygen-cleavable-prodrugs-with-ppix-pdt
#1
JOURNAL ARTICLE
Kazi Md Mahabubur Rahman, Soniya Kumbham, Ganesh Bist, Sukyung Woo, Barbara A Foster, Youngjae You
It has been 30 years since Photofrin-PDT was approved for the treatment of bladder cancer in Canada. However, Photofrin-PDT failed to gain popularity due to bladder complications. The PDT with red light and IV-administered Photofrin could permanently damage the bladder muscle. We have been developing a new combination strategy of PpIX-PDT with singlet oxygen-cleavable prodrugs for NMIBC with minimal side effects, avoiding damage to the bladder muscle layer. PpIX can be excited by either green (532 nm) or red (635 nm) light...
March 27, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38528682/modification-of-traditional-composite-nonwovens-with-stable-storage-of-light-absorption-transients-and-photodynamic-antibacterial-effect
#2
JOURNAL ARTICLE
Ting-Ting Li, Bing-Bing Shou, Lu Yang, Hai-Tao Ren, Xian-Jin Hu, Jia-Horng Lin, Tao Cai, Ching-Wen Lou
Combining photodynamic antimicrobials with nonwovens is prospective. However, common photosensitizers still have drawbacks such as poor photoactivity and the inability to charge. In this study, a photodynamic and high-efficiency antimicrobial protective material was prepared by grafting bis benzophenone-structured 4,4-terephthaloyl diphthalic anhydride (TDPA) photosensitizer, and antimicrobial agent chlorogenic acid (CA) onto spunbond-meltblown-spunbond (SMS) membranes. The charging rates for · OH and H2 O2 were 6377...
March 25, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38504445/compound-collagen-peptide-powder-improves-skin-photoaging-by-reducing-oxidative-stress-and-activating-tgf-%C3%AE-1-smad-pathway
#3
JOURNAL ARTICLE
Kaien Guo, Linxin Zheng, Xin Zeng, Guangchun Huang, Lingling Meng, Yuting Yin
Fish collagen peptide (FCP) has been extensively investigated as a natural product that can combat photoaging; however, its efficacy is limited by its singular composition. Compound collagen peptide powder (CCPP) is a novel functional food formulation that exhibits photoprotective properties and comprises FCP and a blend of natural botanical ingredients. The objective of this study was to investigate the efficacy of CCPP and its molecular mechanism. CCPP had a low molecular weight, facilitating its efficient absorption, and was abundant in amino acids, total polyphenols, and total flavonoids...
March 19, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38488188/highways-and-detours-in-the-realm-of-photodynamic-therapy-for-cancer-control
#4
LETTER
David Kessel
Critical elements of photodynamic therapy are a photosensitizing agent, light at a wavelength corresponding to an absorbance band of the agent, and sufficient oxygenation to create a cytotoxic concentration of reactive oxygen species. Other factors may promote efficacy, but these are critical.
March 15, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38485671/metal-semiconductor-heterojunction-accelerates-the-plasmonically-powered-photoregeneration-of-biological-cofactors
#5
JOURNAL ARTICLE
Namitha Deepak, Vanshika Jain, Pramod P Pillai
Photocatalysis with plasmonic nanoparticles (NPs) is emerging as an attractive strategy to make and break chemical bonds. However, the fast relaxation dynamics of the photoexcited charge carriers in plasmonic NPs often result in poor yields. The separation and extraction of photoexcited hot-charge carriers should be faster than the thermalization process to overcome the limitation of poor yield. This demands the integration of rationally chosen materials to construct hybrid plasmonic photocatalysts. In this work, the enhanced photocatalytic activity of gold nanoparticle-titanium dioxide metal-semiconductor heterostructure (Au-TiO2 ) is used for the efficient regeneration of nicotinamide (NADH) cofactors...
March 14, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38477138/effectiveness-of-lapatinib-for-enhancing-5-aminolevulinic-acid-mediated-protoporphyrin-ix-fluorescence-and-photodynamic-therapy-in-human-cancer-cell-lines-with-varied-abcg2-activities
#6
JOURNAL ARTICLE
Richard Howley, Jordyn Olsen, Bin Chen
5-Aminolevulinic acid (ALA) is a prodrug for protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) and fluorescence-guided tumor surgery. We previously reported that lapatinib, a repurposed ABCG2 inhibitor, enhanced ALA-induced PpIX fluorescence and PDT by blocking ABCG2-mediated PpIX efflux. In the present study, we evaluated how the variation in ABCG2 activities/protein levels affected tumor cell response to the enhancement of PpIX/PDT by lapatinib and Ko143, an ABCG2 tool inhibitor. ABCG2 activities and protein levels were determined in a panel of human cancer cell lines...
March 13, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38462542/effect-of-980%C3%A2-nm-photobiomodulation-delivered-by-a-handpiece-with-gaussian-vs-flat-top-profiles-on-proliferation-and-differentiation-of-buccal-fat-pad-stem-cells
#7
JOURNAL ARTICLE
Ali Homayouni, Maryam Rezaie Rad, Hamidreza Barikani, Nasim Chiniforush, Solmaz Akbari
The aim of this study was to compare the effectiveness of the Gaussian and Flat-Top profiles in proliferation and differentiation of mesenchymal stem cell of buccal fat pad. Based on the timing schedule and type of laser handpieces, the cells were assigned to a control group with no radiation, and two irradiation test groups (980 nm) with Flat-Top (F) (power of 1.1 W, beam area of 1 cm2 ) and standard Gaussian (G) (power of 0.7 W, beam area of 0.5 cm2 ) handpieces. Each test group was divided into three subgroups, receiving one time (60 J/cm2 ), two times (120 J/cm2 ), and three times (180 J/cm2 ) irradiation...
March 10, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38459721/the-rev-erb-antagonist-sr8278-modulates-keratinocyte-viability-in-response-to-uva-and-uvb-radiation
#8
JOURNAL ARTICLE
William Cvammen, Michael G Kemp
The nucleotide excision repair (NER) system removes UV photoproducts from genomic DNA and is controlled by the circadian clock. Given that small-molecule compounds have been developed to target various clock proteins, we examined whether the cryptochrome inhibitor KS15 and REV-ERB antagonist SR8278 could modulate keratinocyte responses to UV radiation in vitro. We observed that though SR8278 promoted cell viability in UVB-irradiated cells, it had little effect on NER or on the expression of the clock-regulated NER factor XPA...
March 8, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38459693/molecular-rotors-of-naphthalimide-and-benzodithiophene-as-effective-solvent-polarity-probes-temperature-sensors-and-for-g-c-3-n-4-sensitization
#9
JOURNAL ARTICLE
Anita Kumari, Sushil Sharma, Sanchita Sengupta
Acceptor-donor-acceptor (A-D-A) molecular rotors have drawn substantial attention for their applications in monitoring temperature variations within cellular microenvironments, biomimetic photocatalysis, and bioimaging. In this study, we have synthesized two novel rotor molecules, NBN1 and NBN2, by incorporating benzodithiophene (BDT) as the donor core and naphthalic anhydride/naphthalimide (NA/NI) moieties as acceptors using Pd-catalyzed Stille coupling reactions. These molecules exhibited distinct charge transfer (CT) behavior in both their absorption and emission spectra and displayed prominent emission solvatochromism...
March 8, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38456366/potential-of-using-medicinal-plant-extracts-as-photosensitizers-for-antimicrobial-photodynamic-therapy
#10
JOURNAL ARTICLE
Aliaksandr V Mikulich, Vitaly Yu Plavskii, Antonina I Tretyakova, Raman K Nahorny, Andrey N Sobchuk, Natalia V Dudchik, Olga A Emeliyanova, Anastasia I Zhabrouskaya, Ludmila G Plavskaya, Tatsiana S Ananich, Olga N Dudinova, Ihar A Leusenka, Sergey V Yakimchuk, Alexei D Svechko, Tran Quoc Tien, Quang Cong Tong, Thanh Phuong Nguyen
Antimicrobial photodynamic therapy (APDT) is a promising approach to overcome antimicrobial resistance. However, for widespread implementation of this approach, approved photosensitizers are needed. In this study, we used commercially available preparations (Calendulae officinalis floridis extract, Chamomillae recutitae floridis extract, Achillea millefolii herbae extract; Hypericum perforatum extract; Eucalyptus viminalis folia extract) as photosensitizers for inactivation of gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria...
March 8, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38445797/application-of-tnb-in-dual-photo-controlled-release-of-phenamacril-imidacloprid-and-imidacloprid-synergist
#11
JOURNAL ARTICLE
Qi Yin, Wen Fu, Xinyue Hu, Zhiping Xu, Zhong Li, Xusheng Shao
Pesticides can improve crops' yield and quality, but unreasonable applications of pesticides lead to waste of pesticides which are further accumulated in the environment and threaten human health. Developing the release of controlled drugs can improve the utilization rate of pesticides. Among these methods, light-controlled release is a new technology of controlled release, which can realize spatiotemporal delivery of drugs by light. Four compounds, named Imidacloprid-Thioacetal o-nitrobenzyl-Phenamacril (IMI-TNB-PHE), Imidacloprid-Thioacetal o-nitrobenzyl- Imidacloprid (IMI-TNB-IMI), Phenamacril-Thioacetal o-nitrobenzyl-Phenamacril (PHE-TNB-PHE), and Imidacloprid-Thioacetal o-nitrobenzyl-Imidacloprid Synergist (IMI-TNB-IMISYN), were designed and synthesized by connecting thioacetal o-nitrobenzyl (TNB) with pesticides TNB displaying simple and efficient optical properties in this work...
March 6, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38445720/photoprotective-effect-of-topical-treatment-with-lopezia-racemosa-extract-against-deleterious-uvb-irradiation-effects-in-the-skin-of-hairless-mice
#12
JOURNAL ARTICLE
Nolasco Ontiveros Erick, Espinosa González Adriana Montserrat, Estrella Parra Edgar Antonio, Serrano Parrales Rocío, López Urrutia Eduardo, García Castillo Verónica, Rodríguez-Sosa Miriam, Juárez-Avelar Imelda, Benítez Flores José Del Carmen, Rivera Cabrera José Cruz, Hernández Delgado Claudia Tzasna, García Bores Ana María, Avila Acevedo José Guillermo
Lopezia racemosa is known as a "mosquito flower or perlilla." It is commonly found in corn crops. In traditional Mexican medicine, this plant is used to treat stomach cancer and urinary tract infections. Likewise, compounds and extracts isolated from plants have shown cytotoxic and anti-inflammatory effects. The objective of this study was to evaluate the photochemoprotective effect of topical treatment with the methanolic extract of L. racemosa (MELR) as a photochemoprotective agent against the harmful effects of UV irradiation (UVR) on a bacterial model and hairless mice...
March 6, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38433456/the-acid-sphingomyelinase-inhibitor-imipramine-enhances-the-release-of-uv-photoproduct-containing-dna-in-small-extracellular-vesicles-in-uvb-irradiated-human-skin
#13
JOURNAL ARTICLE
M Alexandra Carpenter, Anita Thyagarajan, Madison Owens, Risha Annamraju, Christina B Borchers, Jeffrey B Travers, Michael G Kemp
Nucleic acids, lipids, and other cell components can be found within different types of extracellular vesicles (EVs), which include apoptotic bodies (ABs), large extracellular vesicles (LEVs), and small extracellular vesicles (SEVs). Release of LEVs from cells can be reduced by genetic or pharmacological inhibition of the enzyme acid sphinogomyelinase (aSMase), and indeed several studies have demonstrated a role for the clinically approved aSMase inhibitor imipramine in blocking LEV release, including in response to UVB exposure...
March 3, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38433310/mitochondrial-targeting-improves-the-selectivity-of-singlet-oxygen-cleavable-prodrugs-in-nmibc-treatment
#14
JOURNAL ARTICLE
Kazi Md Mahabubur Rahman, Ganesh Bist, Soniya Kumbham, Barbara A Foster, Sukyung Woo, Youngjae You
Mitochondria play an essential role in cancer treatment by providing apoptotic signals. Hexyl aminolevulinate, an FDA-approved diagnosis for non-muscle invasive bladder cancer, induces the production of protoporphyrin IX (PpIX) preferentially by mitochondria in cancer cells. Photosensitizer PpIX upon illumination can release active chemotherapy drugs from singlet oxygen-activatable prodrugs. Prodrugs placed close enough to PpIX formed in mitochondria can improve the antitumor efficiency of PpIX-PDT. The preferred uptake of prodrugs by cancer cells and tumors can further enhance the selective damage of cancer cells over non-cancer cells and surrounding normal tissues...
March 3, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38419115/dansyl-tagged-xanthate-ester-as-a-capping-agent-to-synthesize-fluorescent-silver-nanoparticles-with-binding-affinity-toward-serum-albumin
#15
JOURNAL ARTICLE
Debashis Barik, Chandrasekhar Pidikaka, Mintu Porel
Developing multifunctional nanomaterials with distinct photochemical properties, such as high quantum yield, improved photostability, and good biocompatibility is critical for a wide range of biomedical applications. Motivated by this, we designed and synthesized a dansyl-tagged xanthate-based capping agent (DX) for the synthesis of fluorescent silver nanoparticles (AgNPs). The capping agent DX was characterized by 1 H and 13 C-NMR, LC-MS, and FT-IR. The synthesized DX-capped fluorescent AgNPs were thoroughly characterized by UV-visible spectroscopy, fluorescence spectroscopy, field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), dynamic light scattering (DLS), and zeta potential...
February 28, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38396365/antiradical-capacity-assay-for-hydrophobic-substances-using-hemin-catalyzed-luminol-chemiluminescence-in-cationic-micelles
#16
JOURNAL ARTICLE
Cerize S Santos, Marcos P O Lemos, Larissa M Betschart, Wilhelm J Baader
Antioxidant substances which can diminish the steady-state concentration of free radicals in vivo are important in the human dietary to diminish the deleterious effects of oxidative stress. As the potential of certain substances as antioxidants is difficult to be verified in vivo, simple chemical in vitro assays which test the potential of substances as antioxidants are of great importance for the screening of new antioxidants. These assays measure the capacity of a substance to suppress free radicals...
February 23, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38385897/fluorescent-styrenes-for-mitochondrial-imaging-and-viscosity-sensing
#17
JOURNAL ARTICLE
Deepmala Singh, Mohini Ghorpade, Ramprasad Regar, Mayeul Collot, Virupakshi Soppina, Sriram Kanvah
Fluorophores bearing cationic pendants, such as the pyridinium group, tend to preferentially accumulate in mitochondria, whereas those with pentafluorophenyl groups display a distinct affinity for the endoplasmic reticulum. In this study, we designed fluorophores incorporating pyridinium and pentafluorophenyl pendants and examined their impact on sub-cellular localization. Remarkably, the fluorophores exhibited a notable propensity for the mitochondrial membrane. Furthermore, these fluorophores revealed dual functionality by facilitating the detection of viscosity changes within the sub-cellular environment and serving as heavy-atom-free photosensitizers...
February 22, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38356286/reconciling-td-dft-and-caspt2-electronic-structure-methods-for-describing-the-photophysics-of-dna
#18
JOURNAL ARTICLE
Vishal Kumar Jaiswal, Mario Taddei, Daniel R Nascimento, Marco Garavelli, Irene Conti, Artur Nenov
Time-dependent density functional theory (TD-DFT) and multiconfigurational second-order perturbation theory (CASPT2) are two of the most widely used methods to investigate photoinduced dynamics in DNA-based systems. These methods sometimes give diverse dynamics in physiological environments usually modeled by quantum mechanics/molecular mechanics (QM/MM) protocol. In this work, we demonstrate for the uridine test case that the underlying topology of the potential energy surfaces of electronic states involved in photoinduced relaxation is similar in both electronic structure methods...
February 14, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38348536/blue-light-impairs-the-repair-of-uvb-induced-pyrimidine-dimers-in-a-human-skin-model
#19
JOURNAL ARTICLE
Thierry Douki, Daniel Bacqueville, Carine Jacques, Camille Geniès, Nicolas Roullet, Sandrine Bessou-Touya, Hélène Duplan
In recent years, interest is growing in the biological cutaneous effects of high-energy visible light (400-450 nm). In the present study, we explored the impact of blue light (BL) on the repair of pyrimidine dimers, the major class of premutagenic DNA damage induced by exposure to sunlight. We unambiguously demonstrate that the exposure of in vitro reconstructed human epidermis to environmentally relevant doses of BL strongly decreases the rate of repair of cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidone photoproducts induced by a subsequent UVB irradiation...
February 13, 2024: Photochemistry and Photobiology
https://read.qxmd.com/read/38339836/associations-between-sun-exposure-skin-ph-and-epidermal-permeability-in-pregnancy-a-longitudinal-observational-study
#20
JOURNAL ARTICLE
Rachel Stevens, Shelley Gorman, Diana Arabiat, Claus T Christophersen, Debra J Palmer
Little is known about how sun exposure may affect the maternal skin barrier during pregnancy when many hormonal and physiological changes occur. In this longitudinal observational study, 50 pregnant women were recruited at 18-24 weeks' gestation, 25 in summer-autumn, and 25 in winter-spring. At three time points in pregnancy at 18-24, 28-30, and 36-38 weeks' gestation, participants completed a validated sun exposure questionnaire and had skin permeability and surface pH measured on the volar forearm...
February 9, 2024: Photochemistry and Photobiology
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