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Journal of Urology

Farzana A Faisal, Jeffrey J Tosoian, Misop Han, Katarzyna J Macura, Christian P Pavlovich, Tamara L Lotan
PURPOSE: Prostatic adenocarcinoma (PCa) with extraprostatic extension (EPE) detected on prostate needle biopsy (PNB) is an uncommon finding. We aimed to describe the clinical and pathologic findings in a large cohort of PCa patients treated with radical prostatectomy (RP) who had EPE identified on PNB. MATERIALS AND METHODS: Using our institutional pathology database, we identified 83 PCa cases with EPE on PNB between 2000-2018 who underwent treatment with RP and had clinical follow-up information...
November 8, 2018: Journal of Urology
Marieke J Krimphove, Sean A Fletcher, Alexander P Cole, Sebastian Berg, Maxine Sun, Stuart R Lipsitz, Brandon A Mahal, Paul L Nguyen, Toni K Choueiri, Adam S Kibel, Luis A Kluth, Joel S Weissman, Quoc-Dien Trinh
PURPOSE: To investigate quality of care at minority-serving hospitals (MSH) compared to other institutions for men with localized intermediate and high-risk prostate cancer (PCa). METHODS: We identified 536,539 men aged ≥40 years presenting with localized intermediate and high-risk PCa in the United States between 2004-2015 using the National Cancer Database (NCDB). Institutions were ranked according to the proportion of Black and Hispanic patients treated at a given institution, and the top decile institutions were defined as MSH...
November 8, 2018: Journal of Urology
Fatemeh Jalali-Chimeh, Ali Gholamrezaei, Mohammadreza Vafa, Malihe Nasiri, Behnaz Abiri, Tayebeh Darooneh, Giti Ozgoli
PURPOSE: To investigate the effect of vitamin D therapy on sexual function in women with low vitamin D levels and sexual dysfunction. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was conducted on women aged 18-45 years with sexual dysfunction (Female Sexual Functioning Index score of <26.55) and a serum 25[OH]D level of <30 ng/mL. Participants received an intramuscular injection of 300,000 IU cholecalciferol or a placebo at baseline and then after four weeks...
November 2, 2018: Journal of Urology
Riccardo Bertolo, Luca Pozzi
Tumor complexity remains the primary modality by which urologists determine surgical approach and treatment strategy. R.E.N.A.L. and PADUA scores are the most popularly used nephrometry systems. Notwithstanding the common items contributing to the scores, some differences exist between PADUA and R.E.N.A.L. systems, translating into a different final score when assessing the tumor complexity of a renal mass. This represents an issue during quantitative syntheses of literature data and in the setting of retrospective multicentric analyses...
November 2, 2018: Journal of Urology
Jaeseung Shin, Kichang Han, Joon Ho Kwon, Gyoung Min Kim, Doyoung Kim, Seung Chul Han, Hee Joon Kim, Jong Yun Won, Man-Deuk Kim, Do Yun Lee
PURPOSE: To evaluate the safety and clinical efficacy of transarterial embolization for vascular complications after partial nephrectomy. MATERIALS AND METHODS: This retrospective study included 1187 patients who underwent partial nephrectomy between January 2006 and December 2017. In total, 36 patients were referred to the interventional radiology department for vascular complications after partial nephrectomy. Data on demographics, clinical manifestations, angiographic findings, embolization procedure, perioperative details, and the technical and clinical success rates were analyzed...
November 2, 2018: Journal of Urology
Deborah L Jacobson, Rachel Shannon, Emilie K Johnson, Edward M Gong, Dennis B Liu, Carl C Flink, Theresa Meyer, Earl Y Cheng, Bruce W Lindgren
PURPOSE: Among children with recurrent obstruction after pyeloplasty, reoperative pyeloplasty is commonly utilized. We previously reported on reoperative robot-assisted laparoscopic repair for failed pyeloplasty in 16 children and concluded that short term and intermediate outcomes were comparable to open reoperative repair. This updated series reports on longer-term outcomes from an extended series. METHODS: We retrospectively reviewed outcomes of consecutive children with prior failed primary pyeloplasty who underwent robot-assisted laparoscopic reoperative repair at a single institution from 1/2008 to 6/2018...
November 2, 2018: Journal of Urology
Christopher Martin, Benjamin Haaland, Alexander E Tward, Christopher Dechet, Will Lowrance, Robert A Stephenson, Heidi Hanson, Brock O'Neil
PURPOSE: Preoperative counseling incorporating the best-case, worst-case, and most-likely outcome scenarios aid patients' decision making. This information is not readily available for prostate cancer counseling because most patient reported outcomes are presented as averages, which minimize individual patient experiences. Using the Expanded Prostate Index Composite (EPIC), we present data to characterize the best and worst-case after prostatectomy. MATERIALS AND METHODS: EPIC bowel, urinary irritation and continence, and sexual function scores were measured among 1418 men (stratified by baseline function) undergoing prostatectomy...
October 23, 2018: Journal of Urology
Jonathan Clavell Hernández, Landon Trost, Tobias Köhler, Josh Ring, Raymond Traweek, Manaf Alom, Run Wang
PURPOSE: Alternative, or ectopic, reservoir placement (ARP) has recently gained popularity among prosthetic surgeons in order to avoid injury to pelvic structures during inflatable penile prosthesis (IPP) implantation. However, the true incidence of complications associated with these new techniques remain understudied. We carried out a 5-year multi-center retrospective study with the aim to evaluate complications related to alternative reservoir placement. MATERIALS AND METHODS: We retrospectively reviewed databases of IPP surgeries in three institutions from February 2011 to December 2016...
October 23, 2018: Journal of Urology
Sam Li-Sheng Chen, Jean Ching-Yuan Fann, Csilla Sipeky, Teng-Kai Yang, Sherry Yueh-Hsia Chiu, Amy Ming-Fang Yen, Virpi Laitinen, Teuvo Lj Tammela, Ulf-Håkan Stenman, Anssi Auvinen, Johanna Schleutker, Hsiu-Hsi Chen
PURPOSE: Combined information on single nucleotide polymorphisms (SNPs) and prostate-specific antigen (PSA) offers opportunities for improving the performance of screening by risk stratification. We aimed to predict the risk of prostate cancer (PrCa) based on PSA together with SNPs information. MATERIALS AND METHODS: Prospective study of 20,575 men with PSA test and 4,967 men with polygenic risk score for PrCa based on 66 SNPs from the Finnish population-based screening trial for PrCa and 5,269 samples on seven SNPs from the Finnish PrCa DNA study...
October 23, 2018: Journal of Urology
Chad R Ritch, Michael S Cookson, Peter E Clark, Sam S Chang, Kareem Fakhoury, Veronica Ralls, Muang H Thu, David F Penson, Joseph A Smith, Heidi J Silver
PURPOSE: We designed a prospective randomized controlled pilot trial to investigate the effects of an enriched oral nutrition supplement (ONS) on body composition and clinical outcomes following radical cystectomy (RC). MATERIALS AND METHODS: 61 patients were randomized to ONS or multivitamin multimineral supplement (MVI) twice daily during an 8-week perioperative period. Body composition was determined by analysis of abdominal CT images at the L3 vertebra. Sarcopenia was defined as skeletal muscle index <55 cm2 /m2 in males and <39 cm2 /m2 in females...
October 22, 2018: Journal of Urology
Maximilien Baron, Benoit Peyronnet, Annabelle Aublé, Juliette Hascoet, Evelyne Castel-Lacanal, Gabriel Miget, Sabine Le Doze, Thomas Prudhomme, Andrea Manunta, Jean-Nicolas Cornu, Xavier Gamé
PURPOSE: Data on long-term outcomes of intradetrusor injections of botulinum toxin A (BTX-A) for neurogenic detrusor overactivity (NDO) are lacking. The aim of the present manuscript was to assess the outcomes of intradetrusor injections of BTX-A for NDO after more than 10 years of follow-up. METHODS: A retrospective chart review of all consecutive neurological patients who had received either onabotulinumtoxin A or abobotulinumtoxin A intradetrusor injections for NDO between January 2002 and November 2007 at three academic centers, was performed...
October 22, 2018: Journal of Urology
Charles C Peyton, Carl Henriksen, Richard R Reich, Mounsif Azizi, Scott M Gilbert
PURPOSE: The Bladder Cancer Index is a validated condition-specific health questionnaire assessing urinary, bowel and sexual function and quality of life among bladder cancer patients. We aimed to establish minimally important difference score thresholds that signal clinical importance. METHODS: A prospective cohort of 150 patients who underwent radical cystectomy between 2013 and 2016 were followed for one year after surgery. Usable data from 138 patients was analyzed...
October 17, 2018: Journal of Urology
Tyler Etheridge, Jinn-Ing Liou, Tracy M Downs, E Jason Abel, David F Jarrard, Kyle A Richards
PURPOSE: This study explores the effect of Agent Orange (AO) exposure on prostate cancer (PCa) survival in Veterans Affairs (VA) patients receiving androgen deprivation therapy (ADT) for advanced PCa. MATERIALS AND METHODS: We retrospectively examined the association between AO exposure in men with PCa being treated with ADT in national VA databases. Patients were diagnosed with PCa from 2000-2008 with follow-up through May 2016. Clinical, pathologic and demographic variables were compared by AO exposure...
October 12, 2018: Journal of Urology
Elisabeth E Fransen van de Putte, Floris Pos, Barry Doodeman, Bas W G van Rhijn, Elsbeth van der Laan, Petra Nederlof, Michiel S van der Heijden, Jolanda Bloos van der Hulst, Joyce Sanders, Annegien Broeks, J Martijn Kerst, Vincent van der Noort, Simon Horenblas, Andries M Bergman
PURPOSE: In this prospective study we evaluated safety and efficacy of concurrent radiotherapy and panitumumab following neoadjuvant/induction chemotherapy (ICT) and pelvic lymph node dissection (PLND) as a bladder preserving therapy for invasive bladder cancer (BC). MATERIALS & METHODS: Patients with cT1-4N0-2M0 bladder cancer were treated with PLND and 4 cycles of platinum-based ICT, followed by a six-and-half-week schedule of weekly panitumumab (2.5 mg/kg) and concurrent radiotherapy to the bladder (33x2 Gy)(RT/P)...
October 12, 2018: Journal of Urology
Niranjan J Sathianathen, Arveen Kalapara, Mark Frydenberg, Nathan Lawrentschuk, Christopher J Weight, Dipen Parekh, Badrinath R Konety
PURPOSE: To perform an updated systematic review and meta-analysis evaluating patient important outcomes for patients undergoing robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC). MATERIALS AND METHODS: Multiple scientific databases were searched up to July 2018 for randomized controlled trials that compared RARC and ORC. The primary outcomes of interest were: disease progression, major (Clavien III-V) complications and 90-day quality of life...
October 12, 2018: Journal of Urology
Janneke E Stalenhoef, Cees van Nieuwkoop, Petra H Menken, Sandra T Bernards, Henk W Elzevier, Jaap T van Dissel
PURPOSE: Antimicrobial resistance leads to complications in the management of recurrent urinary tract infections (rUTIs). In some rUTI patients with limited treatment options, intravenous therapy with reserve antibiotics is often required. In this study we aimed to assess the effectiveness, safety, and feasibility of prophylactic treatment with intravesical gentamicin in patients with refractory rUTI caused by multidrug-resistant (MDR) microorganisms. MATERIALS AND METHODS: Prospective trial of 63 adults with rUTI caused by MDR pathogens, enrolled at one academic and one general hospital in the Netherlands between 2014 and 2017...
October 11, 2018: Journal of Urology
Eric Walton, Grace Yaguchi, Jacob Keeley, Mustafa Deebajah, Mani Menon, James Peabody, Ali Dabaja, Shaheen Alanee
PURPOSE: The updated Prostate Imaging Reporting and Data System version 2 (PI-RADSTM v2) defines different grading parameters for lesions located in the peripheral zone (PZ) versus the transitional zone (TZ) and has contributed to the implementation of magnetic resonance imaging targeted biopsy (MRI-TB). This study evaluated the efficacy of MRI-TB between African American patients with additional consideration for lesion location on MRI. MATERIALS AND METHODS: A retrospective review of MRI-TB was performed at a single institution treating a racially diverse population...
October 11, 2018: Journal of Urology
Jonathan S Ellison, Paul A Merguerian, Benjamin C Fu, Sarah K Holt, Thomas S Lendvay, Margarett Shnorhavorian
PURPOSE: Imaging following surgical intervention for nephrolithiasis is important to define surgical success as well as to ensure no silent obstruction. We assessed nationwide post-surgical imaging patterns in children undergoing ureteroscopy (URS) and shock wave lithotripsy (SWL). METHODS: We reviewed the Thompson Reuters Marketscan™ Commercial Claims and Encounters database from 2007-2013 for children aged 1-18 years undergoing URS or SWL. Imaging exposure following index procedure within 90 days as a primary analysis and 180 days as a secondary analysis of the index procedure was assessed...
October 11, 2018: Journal of Urology
Evan C Carlos, Chloe E Peters, Daniel A Wollin, Brenton B Winship, Leah G Davis, Jingqiu Li, Charles D Scales, Samuel H Eaton, Glenn M Preminger, Michael E Lipkin
PURPOSE: Emergency department(ED) visits after ureteroscopy(URS) are costly and inconvenient. To better understand those at risk, we aim to identify patient demographic, medical and surgical factors associated with 30-day ED presentation following URS for urolithiasis with particular attention paid to those with a history of a psychiatric diagnosis(PD). MATERIALS AND METHODS: We retrospectively reviewed 1576 cases on 1395 adults who underwent stone-related URS over 3 years at two hospitals...
October 11, 2018: Journal of Urology
Scott C Morgan, Karen Hoffman, D Andrew Loblaw, Mark K Buyyounouski, Caroline Patton, Daniel Barocas, Soren Bentzen, Michael Chang, Jason Efstathiou, Patrick Greany, Per Halvorsen, Bridget F Koontz, Colleen Lawton, C Marc Leyrer, Daniel Lin, Michael Ray, Howard Sandler
PURPOSE: The aim of this guideline is to present recommendations regarding moderately hypofractionated (240-340 cGy per fraction) and ultrahypofractionated (500 cGy or more per fraction) radiation therapy for localized prostate cancer. METHODS AND MATERIALS: The American Society for Radiation Oncology convened a task force to address 8 key questions on appropriate indications and dose-fractionation for moderately and ultrahypofractionated radiation therapy, as well as technical issues, including normal tissue dose constraints, treatment volumes, and use of image guided and intensity modulated radiation therapy...
October 9, 2018: Journal of Urology
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