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Journal of Pharmacy and Pharmacology

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https://www.readbyqxmd.com/read/29148068/gastrodin-protects-myocardial-cells-against-hypoxia-reoxygenation-injury-in-neonatal-rats-by-inhibiting-cell-autophagy-through-the-activation-of-mtor-signals-in-pi3k-akt-pathway
#1
Xiang Li, Qinhui Zhu, Yuanyuan Liu, Zhiyong Yang, Bin Li
OBJECTIVES: This study aimed to investigate the protective effect of gastrodin (GAS) on myocardial cells with hypoxia/reoxygenation (H/R) injury in neonatal rats and explore the underlying mechanism. METHODS: Myocardial cells were extracted from neonatal rats and divided into six groups: control, H/R, H/R + Low-Concentration GAS, H/R + Middle-Concentration GAS, H/R + High-Concentration GAS and H/R + High-Concentration GAS + AKT Inhibitor groups. After 48-h treatment, cell viability, autophagosome quantity and the expression levels of LC3-II, p62, Akt, pAkt, mammalian target of rapamycin (mTOR) and uncoordinated 51-like kinase 1 (ULK1) in myocardial cells were made comparisons among each group...
November 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29148063/studies-on-the-curcumin-phospholipid-complex-solidified-with-soluplus-%C3%A2
#2
Jianan Wang, Lulu Wang, Lan Zhang, Dandan He, Jianming Ju, Weiguang Li
OBJECTIVES: With the purpose of developing a curcumin phospholipid complex (CPC) formulation with high performance, the CPC was prepared and solidified with Soluplus(®) in this study. METHODS: Soluplus(®) was used as a carrier to solidify CPC. The structures of the CPC and curcumin phospholipid complex - Soluplus(®) solidified powder (CSP) - were also characterized by differential scanning electron microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray diffractometer, and flowability, in-vitro dissolution and oral bioavailability were also investigated...
November 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29148061/endocannabinoids-modulate-gq-11-protein-coupled-receptor-agonist-induced-vasoconstriction-via-a-negative-feedback-mechanism
#3
REVIEW
Olga Karpińska, Marta Baranowska-Kuczko, Monika Kloza, Hanna Kozłowska
OBJECTIVES: The endocannabinoid (eCB) system centrally and peripherally regulates cardiovascular parameters, including blood pressure, in health and disease. The relationship between Gq/11 protein-coupled receptor activation, regulation of eCBs release (mainly 2-arachidonoylglycerol) and subsequent CB1 receptor activation was initially observed in the central nervous system. Here, we review the latest findings from systemic physiological studies which include for the first time data from pulmonary arteries...
November 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29125176/hplc-dad-esi-ms-ms-analysis-of-fruits-from-firmiana-simplex-l-and-evaluation-of-their-antioxidant-and-antigenotoxic-properties
#4
Mosad Ahmed Ghareeb, Tamer Mohamed, Amal Mohamed Saad, Laila Abdel-Ghany Refahy, Mansour Sobeh, Michael Wink
OBJECTIVES: The secondary metabolites of the fruits of Firmiana simplex (L.) were analysed by LC-DAD-ESI-MS/MS; furthermore, we evaluated their antioxidant and antigenotoxic properties. METHODS: The antioxidant activity was investigated using the 2,2'-diphenyl-1-picrylhydrazyl radical (DPPH), the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) and the ferric reducing antioxidant power (FRAP) assays. The antigenotoxic potential was determined via the comet assay...
November 10, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29105086/dose-dependent-effect-of-triiodothyronine-on-the-chondrogenic-differentiation-of-mesenchymal-stem-cells-from-the-bone-marrow-of-female-rats
#5
Higor A Assis, Nathalia C Elert, André Luiz B P Azevedo, Iolanda S Braga, Rogéria Serakides, Natália de Melo Ocarino, Alfredo M de Goes, Francisco de Paula Careta, Greiciane G Paneto, Adriana M A da Silva, Jankerle N Boeloni
OBJECTIVES: Verify the in-vitro effect of triiodothyronine (T3) on the chondrogenic differentiation of female rat bone marrow mesenchymal stem cells (BMMSCs) over several time periods and at several doses. METHODS: CD54 + /CD73 + /CD90 +  BMMSCs from Wistar female rats were cultured in chondrogenic medium with or without T3 (0.01; 1; 100; 1000 nm). At seven, 14 and 21 days, the cell morphology, chondrogenic matrix formation and expression of Sox9 and collagen II were evaluated...
November 3, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29072321/standardised-evaluation-of-medicine-acceptability-in-paediatric-population-reliability-of-a-model
#6
Thibault Vallet, Fabrice Ruiz, Marc Lavarde, Anne-Marie Pensé-Lhéritier, Ameziane Aoussat
OBJECTIVES: Our novel tool to standardise the evaluation of medicine acceptability was developed using observational data on medicines use measured in a paediatric population included for this purpose (0-14 years). Using this tool, any medicine may be positioned on a map and assigned to an acceptability profile. The present exploration aimed to verify its statistical reliability. METHODS: Permutation test has been used to verify the significance of the relationships among measures highlighted by the acceptability map...
October 26, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29072315/methyl-jasmonate-a-phytohormone-with-potential-for-the-treatment-of-inflammatory-bowel-diseases
#7
REVIEW
Jean Carlos Fernando Besson, Caroline de Carvalho Picoli, Graciette Matioli, Maria Raquel Marçal Natali
OBJECTIVES: The phytohormone methyl jasmonate (MeJA) has been identified as a vital cell regulator in plants. This substance is analogous to eicosanoids and similar to that of anti-inflammatory prostaglandins. In animals and in animal cells, it displayed an efficient neuroprotective, anti-inflammatory and antioxidant action; while in tumoral strains, it demonstrates a potentially highly attractive mechanism of apoptosis induction through various cellular and molecular mechanisms. The aim of the present review was to explore two new hypotheses that explain the action of MeJA, a lipid phytohormone and its potentially anti-apoptotic mechanism for use as a therapeutic target for future treatment of Inflammatory bowel diseases (IBDs)...
October 26, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29057517/the-indane-diastereoisomers-ph2-and-ph5-divergence-between-their-effects-in-delayed-type-hypersensitivity-models-and-a-model-of-colitis
#8
Neil H Frankish, Brendan McHale, Helen Sheridan
OBJECTIVES: Compounds PH2 and PH5 are distereoisomers of novel indane compounds, synthesised as analogues of secondary metabolites of the fern, Onychium. In this study, we compare their effects on a variety of inflammatory models. METHODS: In an effort to extend our knowledge of their anti-inflammatory profile, we have investigated their activity in two models of delayed-type hypersensitivity (DTH); the methylated bovine serum albumin model (mBSA) and the oxazolone contact hypersensitivity (CHS) model, on IL2 release from Jurkat cells and in the dextran sulphate sodium (DSS) murine model of inflammatory bowel disease...
October 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29057480/cannabinoids-concentration-variability-in-cannabis-olive-oil-galenic-preparations
#9
Chiara Carcieri, Cristina Tomasello, Marco Simiele, Amedeo De Nicolò, Valeria Avataneo, Luca Canzoneri, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio
OBJECTIVES: Knowledge of the exact concentration of active compounds in galenic preparations is crucial to be able to ensure their quality and to properly administer the prescribed dose. Currently, the need for titration of extracts is still debated. Considering this, together with the absence of a standard preparation method, the aim of this study was to evaluate cannabinoids concentrations variability in galenic olive oil extracts, to evaluate the interlot and interlaboratory variability in the extraction yield and in the preparation composition...
October 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29057476/therapeutic-potency-of-pharmacological-adenosine-receptor-agonist-antagonist-in-angiogenesis-current-status-and-perspectives
#10
REVIEW
Amirhossein Bahreyni, Majid Khazaei, Majid Rajabian, Mikhail Ryzhikov, Amir Avan, Seyed M Hassanian
OBJECTIVES: Adenosine concentration significantly increases in tumour microenvironment contributing to tumorigenic processes including cell proliferation, survival, invasion and of special interest in this review angiogenesis. KEY FINDINGS: This review summarizes the role of pharmacological adenosine receptor agonist and antagonist in regulating angiogenesis for a better understanding and hence a better management of angiogenesis-associated disorders. SUMMARY: Depending upon the pharmacological characteristics of adenosine receptor subtypes, adenosine elicits anti- or pro-angiogenic responses in stimulated cells...
October 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29057475/erding-formula-in-hyperuricaemia-treatment-unfolding-traditional-chinese-herbal-compatibility-using-modern-pharmaceutical-approaches
#11
Jieyu Zuo, Hongming He, Zhengyun Zuo, Nádia Bou-Chacra, Raimar Löbenberg
OBJECTIVES: Traditional Chinese herbal formulas are difficult to be understood because of complex compositions and specific therapeutic principles. To better understand herbal compatibility in Traditional Chinese medicine (TCM), this study was conducted to investigate the effects of a Chinese pharmacopoeia-listed formula, Erding Formula (EF) and its constituent herbs for a new indication, hyperuricaemia. METHODS: A hypoxanthine and potassium oxonate-induced hyperuricemic mouse model, a xylene-induced inflammatory mouse model and an acetic acid-induced pain model were used to test the effects of EF and its constituent herbs...
October 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034965/role-of-serum-albumin-as-a-nanoparticulate-carrier-for-nose-to-brain-delivery-of-r-flurbiprofen-implications-for-the-treatment-of-alzheimer-s-disease
#12
Ling Rong Wong, Paul C Ho
OBJECTIVES: R-flurbiprofen (R-FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β-amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration posed a challenge to its further development for AD treatment. In this study, we investigated the potential of serum albumin as nanoparticulate carriers for nose-to-brain delivery of R-FP to improve its brain accumulation. METHODS: Mice were subjected to three treatment groups: (1) intranasal R-FP solution, (2) oral R-FP solution and (3) intranasal R-FP albumin nanoparticles...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034955/a-review-of-issues-of-nomenclature-and-taxonomy-of-hypericum-perforatum-l-and-kew-s-medicinal-plant-names-services
#13
REVIEW
Elizabeth Anne Dauncey, Jason Thomas Whitley Irving, Robert Allkin
OBJECTIVES: To review which names are used to refer to Hypericum perforatum L. in health regulation and medicinal plant references, and the potential for ambiguity or imprecision. KEY FINDINGS: Structured searches of Kew's Medicinal Plant Names Services Resource, supplemented with other online bibliographic resources, found that the scientific name Hypericum perforatum L. is used consistently in the literature, but variation between subspecies is rarely considered by researchers...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034952/viscum-articulatum-burm-f-a-review-on-its-phytochemistry-pharmacology-and-traditional-uses
#14
REVIEW
Bhishma P Patel, Pawan K Singh
OBJECTIVES: The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. METHODS: Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034951/a-nanocrystal-based-formulation-improves-the-pharmacokinetic-performance-and-therapeutic-response-of-albendazole-in-dogs
#15
Alejandro Javier Paredes, Nicolás Litterio, Alicia Dib, Daniel Alberto Allemandi, Carlos Lanusse, Sergio Sánchez Bruni, Santiago Daniel Palma
OBJECTIVES: Here, we aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an albendazole (ABZ) nano-sized formulation in dogs. METHODS: In the pharmacokinetic study, ABZ self-dispersible nanocrystals (SDNCS) and a control formulation were administered orally to healthy dogs (n = 6). The concentrations of the sulphoxide metabolite in plasma were determined by high-performance liquid chromatography. For the anthelmintic efficacy trial, SDNCS and a commercially available formulation of ABZ were given to naturally parasitised dogs...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29023794/attenuation-of-oxidative-stress-and-artificial-wound-closure-in-c2c12-myoblasts-induced-by-sequential-extracts-of-boerhavia-diffusa
#16
Ewura Seidu Yahaya, Werner Cordier, Paul Anton Steenkamp, Vanessa Steenkamp
OBJECTIVES: Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment of wounds and other ailments. The aim of the study was to determine the ability of sequential extracts of B. diffusa to influence oxidation and wound closure in myoblast cells in vitro. METHODS: Sequential extracts were prepared from the whole plant using four solvents of increasing polarity (hexane, ethyl acetate, methanol and water)...
October 12, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28994118/baccharis-dracunculifolia-dc-asteraceae-selectively-modulates-the-effector-functions-of-human-neutrophils
#17
Andréa S G Figueiredo-Rinhel, Lamartine L de Melo, Leandro O Bortot, Everton O L Santos, Micássio F Andrade, Ana Elisa C S Azzolini, Luciana M Kabeya, Antonio Caliri, Jairo K Bastos, Yara Maria Lucisano-Valim
OBJECTIVES: To examine whether the hydroalcoholic extract from Baccharis dracunculifolia leaves (BdE) modulates the human neutrophil oxidative metabolism, degranulation, phagocytosis and microbial killing capacity. METHODS: In-vitro assays based on chemiluminescence, spectrophotometry, flow cytometry and polarimetry were used, as well as docking calculations. KEY FINDINGS: At concentrations that effectively suppressed the neutrophil oxidative metabolism elicited by soluble and particulate stimuli (<10 μg/ml), without clear signs of cytotoxicity, BdE (1) inhibited NADPH oxidase and myeloperoxidase activity; (2) scavenged H2 O2 and HOCl; (3) weakly inhibited phagocytosis; and (4) did not affect neutrophil degranulation and microbial killing capacity, the expression levels of TLR2, TLR4, FcγRIIa, FcγRIIIb and CR3 and the activity of elastase and lysozyme...
October 10, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28994117/melatonin-ameliorates-a%C3%AE-1-42-induced-alzheimer-s-cognitive-deficits-in-mouse-model
#18
Yu-Hang Gong, Nan Hua, Xuan Zang, Tao Huang, Ling He
OBJECTIVES: The objective of this study was to evaluate whether melatonin could ameliorate cognitive function in Aβ1-42 -induced mouse model and its underlying mechanisms. METHODS: Series behaviour tests were performed to demonstrate the amelioration of cognitive function of the Alzheimer's disease (AD) mice induced by Aβ1-42 . Additionally, enzyme-linked immunosorbent assay was applied to detect the expression of Aβ1-42 , BACE1 and p-tau protein in the brain of the AD mice...
October 10, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28994112/celastrol-attenuates-pain-and-cartilage-damage-via-sdf-1-cxcr4-signalling-pathway-in-osteoarthritis-rats
#19
Weifeng Wang, Chengzhi Ha, Tao Lin, Dawei Wang, Yuanhe Wang, Mingzhi Gong
OBJECTIVES: Celastrol has attracted wide interests for its anticancer and anti-inflammation properties, and studies have demonstrated that celastrol negatively modulates the stromal cell-derived factor-1 (SDF-1) and receptor C-X-C chemokine receptor type 4 (CXCR4) signalling. We aim in this study to investigate the effects of celastrol in osteoarthritis (OA) in vivo and explored the underlying molecular mechanisms. METHODS: We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments...
October 10, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28990659/persistence-of-stat-1-inhibition-and-induction-of-cytokine-resistance-in-pancreatic-%C3%AE-cells-treated-with-st-john-s-wort-and-its-component-hyperforin
#20
Michela Novelli, Pascale Beffy, Alex Gregorelli, Svetlana Porozov, Fabrizio Mascia, Chiara Vantaggiato, Pellegrino Masiello, Marta Menegazzi
OBJECTIVES: St John's wort extract (SJW) and its component hyperforin (HPF) were shown to potently inhibit cytokine-induced STAT-1 and NF-κB activation in pancreatic β cells and protect them against injury. This study aimed at exploring the time course of STAT-1 inhibition afforded by these natural compounds in the β-cell line INS-1E. METHODS: INS-1E cells were pre-incubated with SJW extract (2-5 μg/ml) or HPF (0.5-2 μm) and then exposed to a cytokine mixture...
October 9, 2017: Journal of Pharmacy and Pharmacology
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