journal
MENU ▼
Read by QxMD icon Read
search

Journal of Pharmacy and Pharmacology

journal
https://www.readbyqxmd.com/read/28722156/chemometric-evaluation-of-hypericin-and-related-phytochemicals-in-17-in-vitro-cultured-hypericum-species-hairy-root-cultures-and-hairy-root-derived-transgenic-plants
#1
Katarína Nigutová, Souvik Kusari, Selahaddin Sezgin, Linda Petijová, Jana Henzelyová, Miroslava Bálintová, Michael Spiteller, Eva Čellárová
OBJECTIVES: The objective of this study was to ascertain the presence and correlations among eight important secondary metabolites viz. hypericin, pseudohypericin, emodin, hyperforin, rutin, hyperoside, quercetin and quercitrin in different organs of 17 in vitro cultured Hypericum species, along with H. tomentosum and H. tetrapterum hairy root cultures, and hairy root-derived transgenic plants of H. tomentosum. METHODS: Samples were extracted and analysed by LC-MS...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28722151/the-antithrombotic-and-haemostatic-effects-of-lassbio-752-a-synthetic-orally-active-compound-in-an-arterial-and-venous-thrombosis-model-in-rats
#2
Flávia S Frattani, Lidia M Lima, Eliezer J Barreiro, Russolina B Zingali
OBJECTIVES: In this work, we further investigated the effect of the compound LASSBio-752 in thrombosis models in rats. METHODS: Arterial and venous thrombosis model, ex-vivo recalcification time and aPTT and PT. KEY FINDINGS: In the venous thrombosis model, oral administration of LASSBio-752 [48.2 mg (100 μmol)/kg] one hour before the thrombus induction decreased thrombus weight by 37 ± 0.2%. Interestingly, the antithrombotic action of this compound [48...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28722145/dendrobium-nobile-lindl-alkaloids-regulate-metabolism-gene-expression-in-livers-of-mice
#3
Yun-Yan Xu, Ya-Sha Xu, Yuan Wang, Qin Wu, Yuan-Fu Lu, Jie Liu, Jing-Shan Shi
OBJECTIVES: In our previous studies, Dendrobium nobile Lindl. alkaloids (DNLA) has been shown to have glucose-lowering and antihyperlipidaemia effects in diabetic rats, in rats fed with high-fat diets, and in mice challenged with adrenaline. This study aimed to examine the effects of DNLA on the expression of glucose and lipid metabolism genes in livers of mice. METHODS: Mice were given DNLA at doses of 10-80 mg/kg, po for 8 days, and livers were removed for total RNA and protein isolation to perform real-time RT-PCR and Western blot analysis...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28722130/solubility-and-molecular-interactions-of-ferulic-acid-in-various-isopropanol%C3%A2-%C3%A2-water-mixtures
#4
Nazrul Haq, Nasir A Siddiqui, Faiyaz Shakeel
OBJECTIVE: The solubility of an herbal compound ferulic acid (FA) in various (isopropanol (IPA) + water) mixtures was measured and correlated at temperatures 'T = 298.2 K to 318.2 K' and pressure 'p = 0.1 MPa'. METHODS: The experimental solubilities of FA in mole fraction were determined using a static equilibrium method and correlated with 'Apelblat, Van't Hoff, Yalkowsky and Jouyban-Acree models'. KEY FINDINGS: The maximum mole fraction solubilities of FA were obtained in neat IPA (2...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28722126/investigating-the-effect-of-poly-l-lactic-acid-nanoparticles-carrying-hypericin-on-the-flow-biased-diffusive-motion-of-hela-cell-organelles
#5
Rozhin Penjweini, Sarah Deville, Omid Haji Maghsoudi, Kristof Notelaers, Anitha Ethirajan, Marcel Ameloot
OBJECTIVES: In this study, we investigate in human cervical epithelial HeLa cells the intracellular dynamics and the mutual interaction with the organelles of the poly-l-lactic acid nanoparticles (PLLA NPs) carrying the naturally occurring hydrophobic photosensitizer hypericin. METHODS: Temporal and spatiotemporal image correlation spectroscopy was used for the assessment of the intracellular diffusion and directed motion of the nanocarriers by tracking the hypericin fluorescence...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28722112/in-silico-and-in-vitro-prediction-of-gastrointestinal-absorption-from-potential-drug-eremantholide-c
#6
Tamires G Caldeira, Dênia A Saúde-Guimarães, André B Dezani, Cristina Helena Dos Reis Serra, Jacqueline de Souza
OBJECTIVES: Analysis of the biopharmaceutical properties of eremantholide C, sesquiterpene lactone with proven pharmacological activity and low toxicity, is required to evaluate its potential to become a drug. METHODS: Preliminary analysis of the physicochemical characteristics of eremantholide C was performed in silico. Equilibrium solubility was evaluated using the shake-flask method, at 37.0 °C, 100 rpm during 72 h in biorelevant media. The permeability was analysed using parallel artificial membrane permeability assay, at 37...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28703305/use-of-multicriteria-decision-analysis-for-assessing-the-benefit-and-risk-of-over-the-counter-analgesics
#7
Andrew Moore, Anne Crossley, Bernard Ng, Lawrence Phillips, Özgür Sancak, K D Rainsford
OBJECTIVES: To test the ability of a multicriteria decision analysis (MCDA) model to incorporate disparate data sources of varying quality along with clinical judgement in a benefit-risk assessment of six well-known pain-relief drugs. METHODS: Six over-the-counter (OTC) analgesics were evaluated against three favourable effects and eight unfavourable effects by seven experts who specialise in the relief of pain, two in a 2-day facilitated workshop whose input data and judgements were later peer-reviewed by five additional experts...
July 13, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28703304/assessing-the-influence-of-media-composition-and-ionic-strength-on-drug-release-from-commercial-immediate-release-and-enteric-coated-aspirin-tablets
#8
Frank Karkossa, Sandra Klein
OBJECTIVES: The objective of this test series was to elucidate the importance of selecting the right media composition for a biopredictive in-vitro dissolution screening of enteric-coated dosage forms. METHODS: Drug release from immediate-release (IR) and enteric-coated (EC) aspirin formulations was assessed in phosphate-based and bicarbonate-based media with different pH, electrolyte composition and ionic strength. KEY FINDINGS: Drug release from aspirin IR tablets was unaffected by media composition...
July 13, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28703281/topotecan-loaded-lipid-nanoparticles-as-a-viable-tool-for-the-topical-treatment-of-skin-cancers
#9
João Hélio Venâncio, Lígia Marquez Andrade, Najla Locatelli Santos Esteves, Lara Barroso Brito, Marize Campos Valadares, Gisele Augusto Rodrigues Oliveira, Eliana Martins Lima, Ricardo Neves Marreto, Tais Gratieri, Stephânia Fleury Taveira
OBJECTIVES: This work aimed to evaluate semisolid formulations containing topotecan (TPT) loaded nanostructured lipid carriers (NLC) for topical treatment of skin cancers, as TPT is effective against a variety of tumours. A formulation which increases TPT skin permeation would be extremely desirable. METHODS: TPT-NLC were prepared and incorporated in hydrogels with hydroxyethyl cellulose and chitosan (TPT-NLC-HEC and TPT-NLC-Ch, respectively). Control formulations were obtained by dispersing TPT in HEC and Ch hydrogels (TPT-HEC and TPT-Ch)...
July 13, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28675434/coumarins-as-potential-antidiabetic-agents
#10
REVIEW
Hanbing Li, Yuanfa Yao, Linghuan Li
OBJECTIVES: Even with great advances in modern medicine and therapeutic agent development, the search for effective antidiabetic drugs remains challenging. Coumarins are secondary metabolites found widely in nature plants and used mainly in anticoagulation and antithrombotic therapy. Over the past two decades, however, there has been an increasing body of literatures related to the effects of coumarins and their derivatives on diabetes and its complications. This review aimed to focus on research findings concerning the effects of coumarins against diabetes and its complications using in-vitro and in-vivo animal models, and also to discuss cellular and molecular mechanisms underlying these effects...
July 3, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28675431/a-comprehensive-review-on-anticancer-mechanisms-of-the-main-carotenoid-of-saffron-crocin
#11
REVIEW
Reyhane Hoshyar, Homa Mollaei
OBJECTIVES: Crocin is derived from dried stigmas of Crocus sativus L. (saffron). It has long been used to prevent and treat various diseases. Although crocin is suggested as one of the most effective cancer therapeutic constituents of saffron stigma, its exact molecular mechanisms are not fully understood. In this study, we reviewed anticancer effects of crocin and its underlying molecular mechanisms. KEY FINDINGS: While several mechanisms may account for the antitumour activity of crocin, alteration of expression/activity of the genes and also epigenetic changes may be considered as necessary phenomena...
July 3, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28664619/heartwood-extract-from-dalbergia-sissoo-promotes-fracture-healing-and-its-application-in-ovariectomy-induced-osteoporotic-rats
#12
Anirudha Karvande, Vikram Khedgikar, Priyanka Kushwaha, Naseer Ahmad, Priyanka Kothari, Ashwni Verma, Padam Kumar, Geet Kumar Nagar, Prabhat Ranjan Mishra, Rakesh Maurya, Ritu Trivedi
OBJECTIVES: This study was undertaken to investigate the effects of a heartwood ethanolic extract (HEE) made from the Dalbergia sissoo on facture healing and in the prevention of pathological bone loss resulting from estrogen deficiency in ovariectomized (Ovx) rats. METHODS: Heartwood ethanolic extract (250, 500 and 1000 mg/kg per day) was administered orally immediately next day after drill-hole injury and continued for 2 weeks. Ovx rats received HEE at same doses for 12 weeks and compared with 17-β estradiol (E2; 100 μg/kg for 5 days/week subcutaneously) group...
June 30, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28664569/development-and-assessment-of-a-new-cage-like-particle-adjuvant
#13
Daiana Bertona, Nazarena Pujato, Iván Bontempi, Verónica Gonzalez, Gabriel Cabrera, Luis Gugliotta, Daniela Hozbor, Alcides Nicastro, Luis Calvinho, Iván Sergio Marcipar
OBJECTIVES: To obtain and assess stable cage-like particles with low surface charge density, which can be prepared using a standardized, economic and scalable method. METHODS: To form these nanoparticles, the lipid composition and proportion as well the method were modified in relation to cage-like particles previously described elsewhere. Bovine albumin was used to compare ISPA performance with that of other adjuvants in mice and to assess stability. Adjuvant efficacy was analysed using a mouse model of Trypanosoma cruzi infection, which shows protection against an intracellular infection that needs a strong cellular response...
June 30, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28653752/the-potential-of-epimedium-koreanum-nakai-for-herb-drug-interaction
#14
Qingxiang Zhong, Ziqi Shi, Li Zhang, Rongling Zhong, Zhi Xia, Jing Wang, Hao Wu, Yutong Jiang, E Sun, Yingjie Wei, Liang Feng, Zhenhai Zhang, Dan Liu, Jie Song, Xiaobin Jia
OBJECTIVES: This study aims to investigate potential herb-drug interactions (HDI) of Epimedium koreanum Nakai. METHODS: Human liver microsomes (HLMs) were used to determine the enzyme kinetics of the major human cytochrome P450s (CYPs). Inducible potential of E. koreanum on CYP1A2, 2B6, 2C19 and 3A4 activities of human primary hepatocytes was also examined. KEY FINDINGS: Ethanol extract of E. koreanum showed direct inhibitory potency for CYP1A2 (IC50  = 121...
June 27, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28653745/st-john-s-wort-for-depression-scoping-review-about-perceptions-and-use-by-general-practitioners-in-clinical-practice
#15
Kirsty Forsdike, Marie Pirotta
BACKGROUND: Extracts of Hypericum perforatum, more commonly known as St John's wort (SJW), have good evidence for treating depression. The herb is easily accessible and widely used by consumers, although it has potential for interaction with other medicines. Consumers' use of SJW is often not discussed with their general practitioners (GPs). It is unclear how GPs perceive use of SJW in practice and the implications for consumers and pharmacists. OBJECTIVE: Explore GPs' perception of SJW use in practice...
June 27, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28653461/choosing-an-optimal-input-for-an-intravenous-glucose-tolerance-test-to-aid-parameter-identification
#16
Emma C Martin, James W T Yates, Kayode Ogungbenro, Leon Aarons
OBJECTIVE: The minimal model is used to estimate insulin sensitivity in patients with diabetes, following an intravenous glucose tolerance test (IVGTT). Issues have been reported regarding parameter estimation, including correlation between insulin sensitivity and action parameters. The objective was to reduce these issues, by modifying the input of glucose in the test. METHODS: Data were available for 24 volunteers following an IVGTT and glucose clamp test. Correlation between parameters was explored using likelihood heatmaps...
June 27, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28643952/asn194lys-mutation-in-rvg29-peptide-increases-gfp-transgene-delivery-by-endocytosis-to-neuroblastoma-and-astrocyte-cells
#17
Sheila Adela Villa-Cedillo, Humberto Rodríguez-Rocha, Laura Mireya Zavala-Flores, Roberto Montes-de-Oca-Luna, Aracely García-García, Maria de Jesus Loera-Arias, Odila Saucedo-Cárdenas
OBJECTIVES: A cell-penetrating peptide-based delivery system could target specific types of cells for therapeutic genes delivery. To increase the gene delivery efficiency into neuronal phenotype cells, we introduced an Asn194Lys mutation to RVG29 peptide derived from rabies virus glycoprotein and added a nuclear localization signal to enhance its nuclear import. METHODS: Mutant RVG or wild-type RVG peptide, a karyophilic peptide (KP) and a plasmid encoding green fluorescent protein (pGL) were bound by electrostatic charges to form four different kinds of RVG complexes...
June 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28643375/dried-blood-spot-sampling-of-nilotinib-in-patients-with-chronic-myeloid-leukaemia-a-comparison-with-venous-blood-sampling
#18
Christel C L M Boons, Abdel Chahbouni, Anneliene M Schimmel, Abraham J Wilhelm, Yvonne M den Hartog, Jeroen J W M Janssen, N Harry Hendrikse, Jacqueline G Hugtenburg, Eleonora L Swart
OBJECTIVES: To compare nilotinib concentrations obtained by venous blood sampling and dried blood spot (DBS) in patients with chronic myeloid leukaemia (CML). It was investigated how to predict nilotinib plasma levels on the basis of DBS. METHODS: Forty duplicate DBS and venous blood samples were collected from 20 patients. Capillary blood was obtained by finger prick and spotted on DMPK-C Whatman sampling paper, simultaneously with venous blood sampling. Plasma concentrations were predicted from DBS concentrations using three methods: (1) individual and (2) mean haematocrit correction and (3) the bias between plasma and DBS concentrations...
June 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28639328/immunogenicity-of-protein-aggregates-of-a-monoclonal-antibody-generated-by-forced-shaking-stress-with-siliconized-and-nonsiliconized-syringes-in-balb-c-mice
#19
Tomonobu Uchino, Yasunori Miyazaki, Takuto Yamazaki, Yoshiyuki Kagawa
OBJECTIVE: In this study, we aimed to investigate the immunogenicity of protein aggregates of monoclonal antibodies (mAbs), generated by forced shaking stress with siliconized and nonsiliconized syringes in a mouse model. METHODS: Samples were filled in siliconized and nonsiliconized syringes with shaking and headspace air. Characterization studies were performed using high-performance size-exclusion chromatography, nanoparticle tracking analysis, flow cytometry, micro-flow imaging and resonant mass measurement...
June 21, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28631822/mesoporous-silica-based-dosage-forms-improve-bioavailability-of-poorly-soluble-drugs-in-pigs-case-example-fenofibrate
#20
Joseph P O'Shea, Kalpa Nagarsekar, Alena Wieber, Vanessa Witt, Elisabeth Herbert, Caitriona M O'Driscoll, Christoph Saal, Dieter Lubda, Brendan T Griffin, Jennifer B Dressman
OBJECTIVES: Mesoporous silicas (SLC) have demonstrated considerable potential to improve bioavailability of poorly soluble drugs by facilitating rapid dissolution and generating supersaturation. The addition of certain polymers can further enhance the dissolution of these formulations by preventing drug precipitation. This study uses fenofibrate as a model drug to investigate the performance of an SLC-based formulation, delivered with hydroxypropyl methylcellulose acetate succinate (HPMCAS) as a precipitation inhibitor, in pigs...
June 20, 2017: Journal of Pharmacy and Pharmacology
journal
journal
23881
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"