Read by QxMD icon Read

Journal of Pharmacy and Pharmacology

Mohammed Elmowafy, Khaled Shalaby, Ayman Salama, Ghareb M Soliman, Nabil K Alruwaili, Ehab M Mostafa, Elshaer F Mohammed, Abd El Ghany A Moustafa, Ameeduzzafar Zafar
OBJECTIVES: This study aims to develop thermosensitive gel containing soy isoflavone (antioxidant and anti-inflammatory natural agent) alginate microspheres for enhancement of wound-healing performance. METHODS: Soy isoflavone microspheres were prepared by ionic cross-linking method and optimized using the Box-Behnken optimization design. Formulations were characterized in terms of particle size, encapsulation efficiency and equilibrium swelling degree. The optimized formula was incorporated in Pluronic F127 gel base and examined for in vivo wound-healing efficacy...
January 14, 2019: Journal of Pharmacy and Pharmacology
Heloisa Arruda Gomm Barreto, Bianca Sestren, Roseli Boergen-Lacerda, Leonardo Cavadas da Costa Soares
OBJECTIVES: To evaluate the advantages and disadvantages of using different standard concentration infusions for high-alert inotropic and vasoactive drugs in paediatric intensive care units (ICUs). METHODS: Retrospective data analysis was performed on drug prescriptions for patients in paediatric ICUs. A matrix was developed based on optimal concentration recommendations for each drug, taking into consideration solution stability and patient safety. Hypothetical volumes were calculated for three standard solutions (high concentration - HC, low concentration - LC and fluid restriction - FR) and compared to the actual administered volumes to evaluate the impact of the volumes of each standard solution for varying weight ranges in paediatric care...
January 2, 2019: Journal of Pharmacy and Pharmacology
Jing Du, Yuanqiao He, Weiquan Wu, Peng Li, Youwei Chen, Zhiming Hu, Yong Han
OBJECTIVES: Chemotheraputic drug resistance is a critical factor associated with the poor survival in advanced/metastatic pancreatic cancer (PC) patients. METHODS: Human pancreatic cell lines Capan-1 and BXPC-3 were cultured with different concentrations of erlotinib (0, 10, 50, and 100 μm) for 48 h. The relative cell viability and apoptosis was detected using MTT assays and flow cytometry apoptosis analysis, respectively. Transfection of pcDNA-EphA2, si-EphA2 and miR-124 mimic/inhibitor was used to modulate the intracellular level of EphA2 and miR-124...
January 2, 2019: Journal of Pharmacy and Pharmacology
Sebastian Lux, Nicolas Lobos, Carolyne Lespay-Rebolledo, Edison Salas-Huenuleo, Marcelo J Kogan, Christian Flores, Mauricio Pinto, Alejandro Hernandez, Teresa Pelissier, Luis Constandil
OBJECTIVES: To study the antinociceptive effect of single and repeated doses of resveratrol in a bone cancer pain model, and whether this effect is prevented by the Silent Information Regulator 1 (SIRT1) inhibitor selisistat. METHODS: The femoral intercondylar bone of BALB/c mice was injected with 1 000 000 BJ3Z cancer cells. Bone resorption and tumour mass growth (measured by in vivo X-ray and fluorescence imaging), as well as mechanical nociceptive thresholds (von Frey device) and dynamic functionality (rotarod machine), were evaluated during the following 4 weeks...
December 27, 2018: Journal of Pharmacy and Pharmacology
Gangling Chen, Caihong Liu, Guoliang Meng, Chunteng Zhang, Fang Chen, Susu Tang, Hao Hong, Chaofeng Zhang
OBJECTIVES: Cognitive impairment is the main character of Alzheimer's disease (AD). This study mainly focused on whether mogrol, a tetracyclic triterpenoids compound of Siraitia grosvenorii Swingle, can ameliorate the memory impairment induced by Aβ1-42 . METHODS: Memory impairment mice model was made by stereotactic intra-hippocampal microinjection of Aβ1-42 (410 pm/mouse). Mogrol (20, 40, 80 mg/kg) was given to mice by intragastric administration at 3 days after Aβ1-42 injection for totally 3 weeks...
December 26, 2018: Journal of Pharmacy and Pharmacology
Eirini Christodoulou, Maria-Eleni Grafakou, Eleni Skaltsa, Nikolaos Kadoglou, Nikolaos Kostomitsopoulos, Georgia Valsami
OBJECTIVES: To prepare a lyophilized saffron aqueous extract (SFE) and determine its chemical profile and serum and tissue pharmacokinetics after intravenous and oral administration to C57/Bl6J mice. METHODS: Lyophilized SFE was prepared, characterized using semi-preparative HPLC and NMR analysis, and stability studies at room temperature, and was quantified for crocin content with an HPLC-PDA method. After intravenous and oral administration of SFE (60 mg/kg, reconstituted with water for injection) to C57/Bl6J mice, crocetin (derived from in vivo crocin hydrolysis) serum and tissue levels (unconjugated and total) were measured with an HPLC-PDA method and subjected to compartmental and non-compartmental PK analysis...
December 21, 2018: Journal of Pharmacy and Pharmacology
Hongxue Shen, Yi Liu, Huanhuan Zhang, Pinggang Ding, Lan Zhang, Liefeng Zhang, Jianming Ju
OBJECTIVES: To increase the solubility of baicalein (BAI) by preparing BAI-micelles (BAI-M) with Solutol HS15 (HS15) and Poloxamer 188 (F68), thereby improving its oral bioavailability. METHODS: Baicalein micelles were prepared with HS15 and F68 by thin-film dispersion method and optimized by central composite design (CCD) approach. Physicochemical, in vitro release, Caco-2 cell transport and pharmacokinetic studies of BAI-M were performed. KEY FINDINGS: The optimal formulation showed spherical shape by characterization of the transmission electron microscope with average small size (23...
December 14, 2018: Journal of Pharmacy and Pharmacology
Yingqiu Liu, Tianyi Liu, Jing Zhao, Taotao He, Hua Chen, Jiaqing Wang, Weimin Zhang, Wuren Ma, Yunpeng Fan, Xiaoping Song
OBJECTIVES: The drawback of bleeding caused by chronic antiplatelet therapy is persecuting patients with thrombotic diseases severely. Based on the dual-directional regulatory effect of Panax notoginseng on platelet, the present study focused on the effect of Notoginsenoside Ft1, a saponin with effect in promoting platelet aggregation. KEY FINDINGS: According to the present study, Notoginsenoside Ft1 cannot stimulate platelet aggregation independently. However, the effect in enhancing aggregation induced by thrombin, collagen and ADP is peaked at 5-10 μm...
December 14, 2018: Journal of Pharmacy and Pharmacology
Jagjit Singh, Lekha Saha, Neha Singh, Puja Kumari, Alka Bhatia, Amitava Chakrabarti
OBJECTIVES: The role of nuclear factor-2 erythroid related factor-2 (Nrf2) activator, berberine (BBR), has been established in rat model of streptozotocin induced diabetic neuropathy. Around 30-40% of cancer patients, on paclitaxel (PTX) chemotherapy develop peripheral neuropathy. The present study was contemplated with the aim of establishing the neuropathy preventive role of BBR, in paclitaxel induced peripheral neuropathy model in rats. METHODS: A total of 30 Wistar rats were divided into five groups as follows: Group I: dimethyl sulfoxide; Group II: PTX+ 0...
December 10, 2018: Journal of Pharmacy and Pharmacology
Qian-Qian Wang, Cui Zhai, Alafate Wahafu, Yan-Ting Zhu, Yong-Hui Liu, Lian-Qing Sun
OBJECTIVES: The aim of this study was to evaluate the neuroprotective effects of SalB on high glucose (HG)-induced excessive autophagy and apoptosis in vitro. METHODS: The proliferation and apoptosis of RSC96 cells were determined using the MTT assay and flow cytometry, respectively. Western blot analysis was performed to examine the expression of autophagy and apoptosis-related proteins. RT-PCR and flow cytometry were manipulated to examine the level of Bcl-2...
December 7, 2018: Journal of Pharmacy and Pharmacology
Qing Zhao, Xin Wang, Qiaosheng Hu, Ridong Zhang, Yong Yin
OBJECTIVES: Lipopolysaccharide (LPS) contributed to the development and progression of type 2 diabetes mellitus (T2D), while TLR4 is reported to mediate the LPS-induced inflammation in macrophages. However, the potential molecular mechanisms for TLR4-mediated macrophages activation in T2D have not yet to be fully clarified. METHODS: Type 2 diabetes models in C57BL/6J mice were generated by a combination administration of streptozotocin (STZ) and a high-fat diet (HFD)...
December 7, 2018: Journal of Pharmacy and Pharmacology
Ryo Yajima, Kazuaki Matsumoto, Kanako Yokono, Yuki Watabe, Yuki Enoki, Kazuaki Taguchi, Yuya Ise, Shiro Katayama, Junko Kizu
OBJECTIVES: As commercially available pregabalin preparations are limited to oral administration, it is impossible to use it as an adjuvant analgesic for neuropathic cancer-related pain in terminally ill cancer patients with oral feeding difficulties. The objective of this study was to develop a pregabalin suppository to be available at hospitals. METHODS: Pregabalin suppositories were prepared using bases comprising six different compositions of Witepsol H-15, Witepsol S-55, and Witepsol E-75...
December 4, 2018: Journal of Pharmacy and Pharmacology
Elaine Hui-Chien Lee, Sherlyn Sheau-Chin Lim, Kah-Hay Yuen, Chong-Yew Lee
OBJECTIVES: This study aims to investigate the blood-brain barrier (BBB) permeability of curcumin analogues with shortened linkers and their ability to protect against amyloid-beta toxicity in a whole organism model. METHOD: Four curcumin analogues were synthesized. These analogues and curcumin were evaluated for their BBB permeability in the parallel artificial membrane permeability assay. The transgenic Caenorhabditis elegansGMC101 that expresses human Aβ1-42 was treated with the compounds to evaluate their ability to delay Aβ-induced paralysis...
December 4, 2018: Journal of Pharmacy and Pharmacology
Liege C Schwingel, Sara E Bianchi, Giovanni K Zorzi, Paulo Gonçalves, Helder F Teixeira, Valquiria L Bassani
OBJECTIVES: The present study was designed to verify if quercetin (QCT), a flavonoid with antioxidant and antiviral activity, and 3-O-methylquercetin (3OMQ), a quercetin C3-methoxylated derivative, present differences in their behavior against complexation with β-cyclodextrin (β-CD) and the corresponding permeation/retention trhough porcine ear skin, when incorporated into hydroxypropyl methylcellulose (HPMC) or chitosan (CS) hydrogels. METHODS: The influence of β-CD on the skin permeation/retention of QCT and 3OMQ from hydrogels is comparatively evaluated for both flavonoids using porcine ear skin in Franz cells model...
December 3, 2018: Journal of Pharmacy and Pharmacology
Ajinkya M Bhagurkar, Mittal Darji, Prit Lakhani, Priyanka Thipsay, Suresh Bandari, Michael A Repka
OBJECTIVES: To investigate the effects of formulation composition on the physico-chemical and drug release properties of mucoadhesive buccal films prepared by melt extrusion technology, using a response surface methodology. METHODS: Salbutamol sulphate, an antiasthmatic drug was used for this study. Klucel hydroxypropylcellulose (HPC) EF (film-forming polymer), Benecel hydroxypropylmethylcellulose (HPMC) K-15M (drug release retardant) and polyethylene glycol (PEG) 4500 (plasticiser) were the three independent factors utilised for the study...
November 28, 2018: Journal of Pharmacy and Pharmacology
Rui Liu, Corrine C Dobson, Brian C Foster, Tony Durst, Pablo Sanchez, John T Arnason, Cory S Harris
OBJECTIVES: A novel anxiolytic natural health product (NHP) containing Souroubea sympetala and Platanus occidentalis is available for the companion animal market and is currently being developed for clinical evaluation. Addressing the risk of potential NHP-drug interactions, this study investigated S. sympetala and P. occidentalis plant extracts, and their identified bioactive compounds, for effects on the activity of cytochrome P450 (CYP) isozymes and the metabolism of the conventional anti-anxiety medication diazepam...
November 22, 2018: Journal of Pharmacy and Pharmacology
Jhon Fernando Berrío Escobar, Diana Margarita Márquez Fernández, Cristiano Giordani, Francesco Castelli, Maria Grazia Sarpietro
OBJECTIVES: Uridine was conjugated with fatty acids to improve the drug lipophilicity and the interaction with phospholipid bilayers. METHODS: The esterification reaction using carbodiimides compounds as coupling agents and a nucleophilic catalyst allowed us to synthesize tri-acyl ester derivatives of uridine with fatty acids. Analysis of molecular interactions between these tri-acyl ester derivatives and l-α-dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV) - as a mammalian cell membrane model - have been performed by differential scanning calorimetry (DSC)...
November 20, 2018: Journal of Pharmacy and Pharmacology
Yuting Wu, Yun Yue, Shu Fu, Yeli Li, Dongqing Wu, Junyuan Lv, Danli Yang
OBJECTIVES: Reducing endoplasmic reticulum stress (ERS)-induced cardiomyocyte apoptosis is a key strategy for preventing hypertensive heart disease. In our previous study, Icariside II can improve left ventricular remodelling in spontaneously hypertensive rats (SHRs). This study aims to determine whether Icariside II can exert its effect by inhibiting ERS-induced cardiomyocyte apoptosis via the PERK/ATF-4/CHOP signalling pathway. METHODS: Spontaneously hypertensive rats were randomly divided into model group and Icariside II groups...
November 20, 2018: Journal of Pharmacy and Pharmacology
Katia Cilene Ferreira Dias, Jamily Cunha de Almeida, Luna Costa Vasconcelos, Marianna Letícia Vasconcelos Patrocínio, Talita Matias Barbosa, Naiara Coelho Ximenes, Ana Paula de Azevedo Leitão, Bianca Oliveira Louchard, Antônia Torres Ávila Pimenta, Francisco das Chagas Lima Pinto, Luzia Kalyne Almeida Moreira Leal, José Eduardo Ribeiro Honório Junior, Silvânia Maria Mendes Vasconcelos
OBJECTIVES: To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine-induced schizophrenia model. METHODS: Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. At 14th day, 30 min after the last administration of KET, the open-field and pre-pulse inhibition (PPI) tests were performed...
November 19, 2018: Journal of Pharmacy and Pharmacology
Alisa Bahar Beydogan, Zeynep Mine Coskun, Sema Bolkent
OBJECTIVES: A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Δ9 -tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The study aims to investigate the effects of THC treatment on inflammation, lipid profiles and oxidative stress in rat liver with hyperinsulinemia. METHODS: Sprague-Dawley rats were divided into groups: control, fructose (10% fructose in drinking water for 12 weeks), THC (1...
November 14, 2018: Journal of Pharmacy and Pharmacology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"