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Keio Journal of Medicine

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https://www.readbyqxmd.com/read/28392539/headache-caused-by-brain-metastases-of-castration-resistant-prostate-cancer-during-cabazitaxel-therapy
#1
Keitaro Watanabe, Takeo Kosaka, Hiroshi Hongo, Satoshi Tamaki, Mototsugu Oya
We describe the case of a 55-year-old man who underwent four cycles of cabazitaxel therapy for castration-resistant prostate cancer (CRPC). After the fourth cycle of cabazitaxel, the patient experienced severe headaches. Brain gadolinium (Gd) contrast-enhanced magnetic resonance imaging (MRI) revealed multiple brain metastases. A few days later, the patient suffered impaired consciousness that progressed rapidly. The patient was treated for the symptoms of increased intracranial pressure and underwent whole-brain radiation...
April 7, 2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/28392538/listeria-monocytogenes-meningitis-complicating-rotavirus-gastroenteritis-in-an-immunocompetent-child
#2
Takuma Ohnishi, Akiko Kawano, Mayumi Araki, Yuko Hamahata, Machiko Usui, Motoko Shimoyamada, Takuya Tamame, Masayuki Akashi, Seiji Sato
Listeria monocytogenes only occasionally causes bacterial meningitis in immunocompetent children. We report a case of L. monocytogenes meningitis associated with rotavirus gastroenteritis. The patient was a previously healthy 20-month-old girl who was admitted because of sustained fever and lethargy after suffering from gastroenteritis for 6 days. The patient's peripheral white blood cell count was 18,600/µL and the C-reactive protein level was 2.44 mg/dL. A stool sample tested positive for rotavirus antigen...
April 7, 2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/28123135/chronological-spontaneous-partial-regression-of-a-cerebral-arteriovenous-malformation-twenty-four-years-follow-up
#3
Dai Kamamoto, Satoshi Takahashi, Kazunari Yoshida
No abstract text is available yet for this article.
January 26, 2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27319977/cutaneous-metaplastic-synovial-cyst-case-report-and-literature-review-from-the-dermatological-point-of-view
#4
Masahiro Fukuyama, Yohei Sato, Jun Hayakawa, Manabu Ohyama
Cutaneous metaplastic synovial cysts (CMSCs) are rare tumors typically comprising a solitary, well-circumscribed cystic mass that is not connected to the joint. Synovial cysts have been reported predominantly by orthopedists or pathologists; however, the presence of CMSC is not generally well recognized by dermatologists. Herein, we report a CMSC in a 68-year-old woman receiving systemic corticosteroid therapy for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA). We attempt to delineate the clinical characteristics of this unusual neoplasm by reviewing the literature, focusing especially on dermatological descriptions...
March 25, 2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/28111378/differential-x-chromosome-inactivation-patterns-during-the-propagation-of-human-induced-pluripotent-stem-cells
#5
Tomoko Andoh-Noda, Wado Akamatsu, Kunio Miyake, Tetsuro Kobayashi, Manabu Ohyama, Hiroshi Kurosawa, Takeo Kubota, Hideyuki Okano
Human induced pluripotent stem cells (hiPSCs) represent a potentially useful tool for studying the molecular mechanisms of disease thanks to the ability to generate patient-specific hiPSC clones. However, previous studies have reported that DNA methylation profiles, including those for imprinted genes, may change during passaging of hiPSCs. This is particularly problematic for hiPSC models of X-linked disease, as unstable X chromosome inactivation status may affect the detection of phenotypes. In the present study, we examined the epigenetic status of hiPSCs derived from patients with Rett syndrome, an X-linked disease during long-term culture...
January 20, 2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/28356548/linking-pathogen-virulence-host-immunity-and-the-microbiota-at-the-intestinal-barrier
#6
Gabriel Nunez
The mechanisms that allow enteric pathogens to colonize the intestine and host immunity as well as the indigenous microbiota to inhibit pathogen colonization remain poorly understood. Our laboratory is using Citrobacter rodentium, a mouse pathogen that models human infections by enteropathogenic E. coli, to understand the mechanisms that regulate the colonization and clearance of the pathogen in the gut. These studies have revealed how the pathogen colonizes and replicates successfully early during infection and how host immunity and the indigenous microbiota cooperate to eradicate the pathogen in the later stage of the infection...
2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/28356547/mechanisms-of-ips-cell-generation-and-beyond
#7
Keisuke Kaji
The generation of induced pluripotent stem cells (iPSCs) achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc, transformed our classical views of the cellular epigenetic landscape and delivered a new concept for cell and tissue engineering. In addition to iPSCs, several other cell types have also been generated by master transcription factor (TF)-mediated transdifferentiation. However, the critical molecular mechanisms amongst diverse cellular identity changes are not well understood. Through the investigation of reprogramming mechanisms, we recently revealed that over-expression of constitutive active Smad3 boosted not only iPSC generation, but also 3 other master TF-mediated conversions, from B cells to macrophages, myoblasts to adipocytes, and human fibroblasts to neurons...
2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27237784/warfarin-associated-intraspinal-hematoma
#8
Joji Inamasu, Keisuke Ito, Natsuki Hattori, Yuichi Hirose
Intracerebral hemorrhage is a well-known complication resulting from warfarin use; however, warfarin-associated intraspinal hematoma is very rare. Warfarin-associated intraspinal hematoma may exhibit delayed progression, and patients may present with atypical symptoms, occasionally resulting in delayed diagnosis. We report the case of a 65-year-old man who visited our emergency department (ED) with acute urinary retention. He had been previously diagnosed with non-valvular atrial fibrillation, arterial hypertension, and benign prostatic hyperplasia, and he used warfarin for the prevention of systemic embolism...
December 25, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27170234/contrast-induced-acute-kidney-injury
#9
REVIEW
Koichiro Homma
Because of the increased use of contrast media, the potential risk of contrast-induced acute kidney injury (CIAKI) has also increased. CIAKI often results in chronic kidney disease (CKD), an affliction with increasing incidence in modern society. The current prevalence of CIAKI is difficult to estimate because most victims are asymptomatic. The first Japanese guidelines regarding contrast agent examinations were recently announced, but their only recommendation is to provide classic fluid replacement with saline 6-12 h before and after the contrast procedure...
December 25, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27990008/anemia-treatment-by-erythropoiesis-stimulating-agents-during-the-6-months-before-initiation-of-hemodialysis-comparison-between-darbepoetin-alfa-and-continuous-erythropoietin-receptor-activator
#10
Tadashi Yoshida, Matsuhiko Hayashi
Anemia in chronic kidney disease (CKD) is a risk factor for cardiovascular diseases and is treated by long-acting erythropoiesis-stimulating agents (ESA). Although results of previous studies showed that the hemoglobin level could not be maintained at initiation of dialysis in CKD patients treated with recombinant human erythropoietin, it remains undetermined if long-acting ESA are effective to prevent the progression of anemia at initiation of dialysis. In the present study, hemoglobin levels in 40 CKD patients treated with darbepoetin alfa (DA) and 15 CKD patients treated with a continuous erythropoietin receptor activator (CERA) were retrospectively compared during the 6 months period prior to initiation of dialysis...
December 19, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27319976/cardiopulmonary-resuscitation-training-in-schools-a-comparison-of-trainee-satisfaction-among-different-age-groups
#11
COMPARATIVE STUDY
Shingo Hori, Masaru Suzuki, Motoyasu Yamazaki, Naoki Aikawa, Hajime Yamazaki
Cardiopulmonary resuscitation (CPR) has recently been added to the school curriculum worldwide and is currently taught to students between the ages of 10 and 16 years. The effect of the age of trainees on their satisfaction with CPR training has yet been elucidated. The aim of this study was to compare the satisfaction of trainees of different ages who participated in CPR training in schools in Japan. In total, 392 primary school students (10-11 years old), 1798 junior high school students (12-13 years old), and 4162 high schools students (15-16 years old) underwent the same 3-h course of CPR training, according to the guidelines of 2000 for Emergency Cardiovascular Care and CPR...
September 25, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27498746/potential-universal-application-of-high-intensity-interval-training-from-athletes-and-sports-lovers-to-patients
#12
Azuma Koichiro, Matsumoto Hideo
Recently, high-intensity interval training (HIIT) has received much attention as a promising exercise option not only to improve aerobic fitness, but also to prevent and improve lifestyle-related diseases. Epidemiological studies have shown that the exercise volume, as determined by the product of exercise intensity, duration, and frequency, has been shown to be important for improvements in muscle mitochondrial activity and subsequent improvements in aerobic fitness, insulin sensitivity, and metabolic variables...
August 8, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27170235/cardiac-senescence-heart-failure-and-frailty-a-triangle-in-elderly-people
#13
REVIEW
Ken Shinmura
Cardiovascular disease (CVD) is a common problem in the elderly. In particular, the morbidity and mortality of patients with heart failure (HF) increase with age. The poor outcomes of elderly patients with HF can be explained partly by cardiac aging at the cellular and organ levels. Moreover, recent evidence has demonstrated that functional evaluation, which may reflect the status of individual aging, predicts mortality in patients with HF. Age-related changes occur throughout the body and in virtually all organ systems...
June 25, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/26853879/vitamin-d-deficiency-with-high-intact-pth-levels-is-more-common-in-younger-than-in-older-women-a-study-of-women-aged-39-64-years
#14
Takeshi Miyamoto, Eri Katsuyama, Hiroya Kanagawa, Atsuhiro Fujie, Hiroya Miyamoto, Shigeyuki Yoshida, Tomoaki Mori, Kana Miyamoto, Yuiko Sato, Tami Kobayashi, Masaya Nakamura, Morio Matsumoto, Yuji Nishiwaki, Hiroshi Hirose, Takeshi Kanda, Ikuo Saito, Yoshiaki Toyama
Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderly osteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39-64 years who were not receiving medication for osteoporosis or other bone diseases...
June 25, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/28025425/virus-and-host-events-in-squamous-carcinogenesis
#15
Nicholas Coleman
Our group investigates early and late stages in the development of squamous cell carcinomas (SCCs), in order to identify new approaches to diagnosis and therapy. The principal themes are:1. Transcriptional deregulation of high-risk human papillomavirus (HRHPV)We study mechanisms of HRHPV transcriptional deregulation and competitive cell selection during SCC progression, focussing on the causes and effects of integration of HPV16 into the host genome. We showed that HPV16 integration does not necessarily lead to a competitive growth advantage or increased levels of virus oncogenes...
2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27665866/robotic-assessment-of-upper-limb-function-after-proximal-humeral-fracture-personal-experience-as-a-patient-and-occupational-therapist
#16
Atsuko Nishimoto, Yohei Otaka, Shoko Kasuga, Eri Otaka, Kotaro Yamazaki, Junichi Ushiba, Meigen Liu
Robotics is an emerging field in rehabilitation medicine. Robots have the potential to complement traditional clinical assessments because they can measure functions more precisely and quantitatively than current clinical assessments. We present a patient with a proximal humeral fracture whose recovery process was evaluated with an exoskeleton robotic device. The patient, a 34-year-old woman, suffered a left proximal humeral fracture while snowboarding. She is an occupational therapist and is the first author of this study...
2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27349663/the-mechanism-for-the-effect-of-chinese-medicine-on-strait-episode-of-complex-diseases
#17
Jing-Yan Han
Complex diseases always involve some strait episode, such as myocardial hypertrophy and fibrosis caused by hypertension, microcirculation dysfunction and injury in heart, brain, lever, and intestine following ischemia and reperfusion, endotoxin induced multiorgan injury, and recovery after intestinal mucosa damage, for which intervention by a single medicine remains unsatisfied in clinic.Chinese medicine has been applied in clinic for more than two thousand years, which presents as a healthcare system using compound formula preparation, treatment based on syndrome differentiation and individualization thus has advantage in dealing with strait episode of complex diseases...
2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27349662/perception-of-thromboembolism-risk-differences-between-the-departments-of-internal-medicine-and-emergency-medicine
#18
MULTICENTER STUDY
Giovanni Maria Vincentelli, Manuel Monti, Maria Rosaria Pirro, Giuliano Bertazzoni, Francesco Rocco Pugliese, Maurizio Ciammaichella, Maria Pia Ruggieri, Raffaele Landolfi
The latest developments in emergency medicine (EM) have introduced new typologies of patients that have not been taken into account in previous studies of venous thromboembolism (VTE) risk. The aim of the current study was to evaluate by comparing the main international risk scores whether different perceptions of VTE risk exist in internal medicine (IM) departments and in EM departments. This cross-sectional observational study involved 23 IM and 10 EM departments of 21 different hospitals. The patient data were collected by physicians who were blinded to the purpose of the study...
2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27040887/the-role-of-the-adipocyte-hormone-leptin-in-alzheimer-s-disease
#19
Makoto Ishii
Cognitive deficits are the major manifestation of Alzheimer's disease (AD); however, weight loss can precede the mental decline and correlates with disease severity. Thus, brain circuits controlling body weight may be altered early in AD and could be intrinsic to AD pathobiology. In mouse models, we found that amyloid-beta, a major pathogenic factor in AD, could inhibit hypothalamic neurons in the leptin pathway, which was associated with early body weight/metabolic deficits. Ongoing research seeks to elucidate the mechanisms underlying the body weight/metabolic deficits and hypothalamic dysfunction in AD using both mouse models and clinically relevant human studies...
2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27040886/dynamic-role-of-the-gtp-energy-metabolism-in-cancers
#20
Atsuo T Sasaki
Rapid growing cells like tumor cells need a vast amount of energy to match their high metabolic demand. Guanine triphosphate (GTP) is one of major cellular metabolites and served as a building block for RNA and DNA as well as an energy source to drive cellular activities such as intracellular trafficking, the cell migration and translation. However, how cancer cells regulate GTP energy levels to adapt for their high demand remain largely unknown yet. In addition, how cells detect GTP levels remains unknown...
2016: Keio Journal of Medicine
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