Divya Ramakrishnan, Luis C Farhat, Edoardo F Q Vattimo, Jessica L S Levine, Jessica A Johnson, Bekir B Artukoglu, Angeli Landeros-Weisenberger, Abraham Zangen, Antoine Pelissolo, Carlos A de B Pereira, Christian Rück, Daniel L C Costa, David Mataix-Cols, David Shannahoff-Khalsa, David F Tolin, Elham Zarean, Elisabeth Meyer, Emily R Hawken, Eric A Storch, Erik Andersson, Euripedes C Miguel, Giuseppe Maina, James F Leckman, Jerome Sarris, John S March, Juliana B Diniz, Kenneth Kobak, Luc Mallet, Nienke C C Vulink, Revital Amiaz, Rodrigo Yacubian Fernandes, Roseli G Shavitt, Sabine Wilhelm, Shahrokh Golshan, Sophie Tezenas du Montcel, Stefano Erzegovesi, Upasana Baruah, William M Greenberg, Yuki Kobayashi, Michael H Bloch
INTRODUCTION: Expert consensus operationalized treatment response and remission in obsessive-compulsive disorder (OCD) as a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) reduction ≥35% and score ≤12 with ≤2 on Clinical Global Impressions Improvement (CGI-I) and Severity (CGI-S) scales, respectively. However, there has been scant empirical evidence supporting these definitions. METHODS: We conducted a systematic review and an individual participant data meta-analysis of randomized-controlled trials (RCTs) in adults with OCD to determine optimal Y-BOCS thresholds for response and remission...
March 29, 2024: Journal of Psychiatric Research