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Journal of Psychiatric Research

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https://www.readbyqxmd.com/read/28806578/klotho-dysfunction-a-pathway-linking-the-aging-process-to-bipolar-disorder
#1
Izabela Guimarães Barbosa, Natalia Pessoa Rocha, Gokay Alpak, Erica Leandro Marciano Vieira, Rodrigo Barreto Huguet, Fabio Lopes Rocha, Breno Satler de Oliveira Diniz, Antonio Lucio Teixeira
AIM: Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore, this study was designed to evaluate plasma levels of Klotho in BD patients and controls. METHODS: Forty patients with type 1 BD and 30 controls were enrolled in this study...
August 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28803144/reply-to-insomnia-related-sleep-disruptions-cognition-and-detailed-concurrent-anxiety-testing-during-the-inter-episode-phase-of-bipolar-disorder-a-herculean-task-or-a-necessity
#2
LETTER
Jennifer C Kanady, Adriane M Soehner, Alexandra B Klein, Allison G Harvey
No abstract text is available yet for this article.
August 9, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28803143/insomnia-related-sleep-disruptions-cognition-and-detailed-concurrent-anxiety-testing-during-the-inter-episode-phase-of-bipolar-disorder-a-herculean-task-or-a-necessity
#3
LETTER
Vaitsa Giannouli
No abstract text is available yet for this article.
August 9, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28800529/mental-health-stigma-and-barriers-to-mental-health-care-for-first-responders-a-systematic-review-and-meta-analysis
#4
REVIEW
Peter T Haugen, Aileen M McCrillis, Geert E Smid, Mirjam J Nijdam
OBJECTIVE: It is unclear how many first responders experience barriers to care and stigma regarding mental health care, and how this influences their help-seeking. A systematic review and meta-analysis was conducted on barriers to care and mental health stigma in first responders and their empirical relationship with psychosocial and psychiatric variables. METHODS: The databases Medline, Embase PsycINFO, CINAHL, PILOTS, LILACS, Sociological Abstracts, SocINDEX, and Social Citation Index were searched to identify relevant studies...
August 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28783579/are-adverse-childhood-experiences-and-depression-associated-with-impaired-glucose-tolerance-in-females-an-experimental-study
#5
Katja Wingenfeld, Linn K Kuehl, Anita Boeker, Katharina Schultebraucks, Anne Schulz, Julia Stenzel, Carsten Spitzer, Christian Otte
Adverse childhood experiences (ACE) enhance the risk for mental disorders, e.g. major depressive disorder (MDD). Increasing evidence suggests an association between ACE and impaired physical health, e.g. metabolic syndrome. The aim of this study was to assess several metabolic risk markers in healthy individuals with and without ACE and depressed patients with and without ACE. We examined glucose and insulin release in the oGTT in 33 women with MDD and ACE, 47 women with MDD without ACE, 21 women with ACE but no current or lifetime MDD and 36 healthy women without either MDD or ACE...
August 2, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28810177/use-of-atypical-antipsychotics-in-pregnancy-and-maternal-gestational-diabetes
#6
Alice Panchaud, Sonia Hernandez-Diaz, Marlene P Freeman, Adele C Viguera, Sarah C MacDonald, Alexandra Z Sosinsky, Lee S Cohen
BACKGROUND: Second generation antipsychotic medications (SGAs) are widely used by reproductive-age women to treat a number of psychiatric illnesses. Some SGAs have been associated with an increased risk of developing diabetes, although information regarding their diabetogenic effect in pregnant women is scarce. OBJECTIVE: To evaluate the risk of gestational diabetes (GDM) among women treated with SGA. METHOD: The Massachusetts General Hospital (MGH) National Pregnancy Registry for Atypical Antipsychotics (NPRAA) collects data on drug use, pregnancy outcomes, and other characteristics from pregnant women, ages 18-45 years, using 3 phone interviews conducted at (1) enrollment during pregnancy, (2) 7 months' gestation, and (3) 2-3 months postpartum...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777984/comorbid-sleep-disorders-and-suicide-risk-among-children-and-adolescents-with-bipolar-disorder
#7
Ian H Stanley, Melanie A Hom, Joan L Luby, Paramjit T Joshi, Karen D Wagner, Graham J Emslie, John T Walkup, David A Axelson, Thomas E Joiner
Children and adolescents with bipolar disorder are at increased risk for suicide. Sleep disturbances are common among youth with bipolar disorder and are also independently implicated in suicide risk; thus, comorbid sleep disorders may amplify suicide risk in this clinical population. This study examined the effects of comorbid sleep disorders on suicide risk among youth with bipolar disorder. We conducted secondary analyses of baseline data from the Treatment of Early Age Mania (TEAM) study, a randomized controlled trial of individuals aged 6-15 years (mean ± SD = 10...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777982/letter-to-the-editor-longitudinal-stability-of-neurocognitive-subtypes-in-bipolar-disorder
#8
LETTER
Diego J Martino, María Scápola, Sergio A Strejilevich
No abstract text is available yet for this article.
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777981/childhood-trauma-dimensions-of-psychopathology-and-the-clinical-expression-of-bipolar-disorders-a-pathway-analysis
#9
B Etain, M Lajnef, C Henry, V Aubin, J M Azorin, F Bellivier, T Bougerol, P Courtet, S Gard, J P Kahn, C Passerieux, M Leboyer
BACKGROUND: This study aims at testing for paths from childhood abuse to clinical indicators of complexity in bipolar disorder (BD), through dimensions of affective dysregulation, impulsivity and hostility. METHOD: 485 euthymic patients with BD from the FACE-BD cohort were included from 2009 to 2014. We collect clinical indicators of complexity/severity: age and polarity at onset, suicide attempt, rapid cycling and substance misuse. Patients completed questionnaires to assess childhood emotional, sexual and physical abuses, affective lability, affect intensity, impulsivity, motor and attitudinal hostility...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28772111/prognostic-factors-for-return-to-work-after-depression-related-work-disability-a-systematic-review-and-meta-analysis
#10
REVIEW
Jenni Ervasti, Matti Joensuu, Jaana Pentti, Tuula Oksanen, Kirsi Ahola, Jussi Vahtera, Mika Kivimäki, Marianna Virtanen
Knowledge about factors influencing return to work (RTW) after depression-related absence is highly relevant, but the evidence is scattered. We performed a systematic search of PubMed and Embase databases up to February 1, 2016 to retrieve cohort studies on the association between various predictive factors and return to work among employees with depression for review and meta-analysis. We also analyzed unpublished data from the Finnish Public Sector study. Most-adjusted estimates were pooled using fixed effects meta-analysis...
July 26, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777983/vitamin-d-supplementation-in-bipolar-depression-a-double-blind-placebo-controlled-trial
#11
Wendy K Marsh, Jessica L Penny, Anthony J Rothschild
OBJECTIVE: Bipolar depression is difficult to treat. Vitamin D supplementation is well tolerated and may improve mood via its neurotransmitter synthesis regulation, nerve growth factor enhancement and antioxidant properties. Vitamin D adjunct reduces unipolar depression, but has not been tried in bipolar depression. METHODS: 18-70yos with DSM IV bipolar depression and Vitamin D deficiency (<30 ng/ml) were randomized in a controlled double blind trial of 5000IU Vitamin D3 po qday supplementation versus placebo for twelve weeks...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28759846/the-association-of-folate-and-depression-a-meta-analysis
#12
REVIEW
Ansley Bender, Kelsey E Hagan, Neal Kingston
BACKGROUND: Previous research suggested that folate levels play an important role in the etiology and course of depression. However, the literature has been inconsistent with regard to differences in folate level between individuals with and without depression. The present meta-analysis synthesized the results of previous studies to examine whether individuals with depression had lower levels of folate than individuals without depression. METHODS: Meta-analytic procedures were conducted in accordance with PRISMA guidelines...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28759845/a-comprehensive-model-of-predictors-of-persistence-and-recurrence-in-adults-with-major-depression-results-from-a-national-3-year-prospective-study
#13
Nicolas Hoertel, Carlos Blanco, Maria A Oquendo, Melanie M Wall, Mark Olfson, Bruno Falissard, Silvia Franco, Hugo Peyre, Cédric Lemogne, Frédéric Limosin
Identifying predictors of persistence and recurrence of depression in individuals with a major depressive episode (MDE) poses a critical challenge for clinicians and researchers. We develop using a nationally representative sample, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC; N = 34,653), a comprehensive model of the 3-year risk of persistence and recurrence in individuals with MDE at baseline. We used structural equation modeling to examine simultaneously the effects of four broad groups of clinical factors on the risk of MDE persistence and recurrence: 1) severity of depressive illness, 2) severity of mental and physical comorbidity, 3) sociodemographic characteristics and 4) treatment-seeking behavior...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28756290/exploring-the-association-between-bdnf-val66met-polymorphism-and-suicidal-behavior-meta-analysis-and-systematic-review
#14
Thelma Beatriz González-Castro, Marisol Salas-Magaña, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Yazmín Hernández-Díaz
Suicide is a serious worldwide health problem of critical consequences. Nowadays genetic factors are considered to be an important cause of suicide. The association between Val66Met (rs6265) polymorphism of the BDNF gene and suicide behavior has been increasingly studied. The aim of this study was to perform a meta-analysis in order to unravel the possible association between BDNF gene Val66Met polymorphism and suicide behavior. These meta-analysis and systematic review were performed using 23 articles that searched for a genetic association between Val66Met and suicide behavior, including 4532 cases and 5364 control subjects...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28755620/does-the-increasing-placebo-response-impact-outcomes-of-adult-and-pediatric-adhd-clinical-trials-data-from-the-us-food-and-drug-administration-2000-2009
#15
Arif Khan, Kaysee Fahl Mar, Walter A Brown
In a study of recent antidepressant clinical trial data, it was found placebo response had grown significantly over time and that contrary to expectations, trial outcome measures and success rate were not impacted. The aim of this paper was to evaluate if this trend of increasing placebo response and stable outcome measures could be seen in clinical trial data for Attention-Deficit Hyperactivity Disorder, a different psychiatric condition with susceptibility to placebo response. For this reason, we evaluated efficacy data reported in the FDA Medical and Statistical reviews for 10 ADHD medication programs (4917 patients, 17 trials, 29 treatment arms)...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28793242/frequency-specific-alteration-of-functional-connectivity-density-in-antipsychotic-naive-adolescents-with-early-onset-schizophrenia
#16
Xiao Wang, Yan Zhang, Zhiliang Long, Junjie Zheng, Youxue Zhang, Shaoqiang Han, Yifeng Wang, Xujun Duan, Mi Yang, Jingping Zhao, Huafu Chen
Early-onset schizophrenia (EOS) is a severe mental illness associated with dysconnectivity that widespread in the brain. However, the functional dysconnectivity in EOS are still mixed. Recently, studies have identified that functional connectivity (FC) arises from a band-limited slow rhythmic mechanism and suggested that the dysconnectivity at specific frequency bands may provide more robust biomarkers for schizophrenia. The frequency-specific changes of FC pattern in EOS remain unclear. To address this issue, resting-state functional magnetic resonance imaging data scans from 39 EOS patients (drug-naive) and 31 healthy controls (HCs) were used to assess the FC density (FCD) across slow-4 (0...
July 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28750232/effects-of-chair-yoga-therapy-on-physical-fitness-in-patients-with-psychiatric-disorders-a-12-week-single-blind-randomized-controlled-trial
#17
Saeko Ikai, Hiroyuki Uchida, Yuya Mizuno, Hideaki Tani, Maki Nagaoka, Kenichi Tsunoda, Masaru Mimura, Takefumi Suzuki
INTRODUCTION: Since falls may lead to fractures and have serious, potentially fatal outcomes, prevention of falls is an urgent public health issue. We examined the effects of chair yoga therapy on physical fitness among psychiatric patients in order to reduce the risk of falls, which has not been previously reported in the literature. METHODS: In this 12-week single-blind randomized controlled trial with a 6-week follow-up, inpatients with mixed psychiatric diagnoses were randomly assigned to either chair yoga therapy in addition to ongoing treatment, or treatment-as-usual...
July 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28746904/prophylactic-antidepressant-treatment-following-acute-coronary-syndrome-a-systematic-review-of-randomized-controlled-trials
#18
REVIEW
Ole G Christiansen, Michael T Madsen, Erik Simonsen, Ismail Gögenur
Major depressive disorder is significantly increased in patients following acute coronary syndrome resulting in twofold increased mortality compared with patients without depression. The depression diagnosis is often missed leading to considerable undertreatment. This systematic review assesses the current evidence of primary prophylactic treatment of depression in patients after acute coronary syndrome. The study protocol was prospectively registered at PROSPERO (registration number CRD42015025587). A systematic review were conducted and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
July 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28743064/health-status-and-mobility-limitations-are-associated-with-residential-and-employment-status-in-schizophrenia-and-bipolar-disorder
#19
M Strassnig, D Cornacchio, P D Harvey, R Kotov, L Fochtmann, E J Bromet
INTRODUCTION: Schizophrenia (SCZ) and bipolar disorder (BP) are linked to multiple impairments in everyday functioning which share cognitive and symptom risk factors. Other risk factors for critical aspects of every day functioning (e.g., gainful employment; residential independence) such as physical health have not been evaluated, despite poor health in SCZ and BP. METHODS: We analyzed 20-year follow-up data from the Suffolk County Mental Health Project cohort of consecutive first admissions with a psychotic disorder to 12 psychiatric facilities in Suffolk County, NY, between September 1989 and December 1995...
July 18, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28755554/association-between-plasma-concentrations-of-vitamin-d-metabolites-and-depressive-symptoms-throughout-pregnancy-in-a-prospective-cohort-of-brazilian-women
#20
Amanda C Cunha Figueiredo, Janet Trujillo, Ana Amélia Freitas-Vilela, Ana Beatriz Franco-Sena, Fernanda Rebelo, Geraldo Marcelo Cunha, Maria Beatriz Trindade de Castro, Amanda Farnum, Rana R Mokhtar, Michael F Holick, Gilberto Kac
Plasma concentrations of vitamin D metabolites can be inversely associated with depressive symptoms. However, few longitudinal studies have investigated this association, especially during pregnancy. The aim of this study was to investigate the association between concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxivitamin D [1,25(OH)2D] with the occurrence of depressive symptoms throughout pregnancy. A prospective cohort of 179 women was followed at 5th-13th, 20th-26th and 30th-36th gestational weeks...
July 14, 2017: Journal of Psychiatric Research
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