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Journal of Psychiatric Research

Jennifer C Kanady, Adriane M Soehner, Alexandra B Klein, Allison G Harvey
Sleep disturbance and cognitive dysfunction are two domains of impairment during inter-episode bipolar disorder. Despite evidence demonstrating the importance of sleep for cognition in healthy and sleep-disordered samples, this link has been minimally examined in bipolar disorder. The present study tested the association between insomnia-related sleep disruptions and cognitive dysfunction during inter-episode bipolar disorder. Forty-seven participants with bipolar disorder and a comorbid insomnia diagnosis (BD-Insomnia) and 19 participants with bipolar disorder without sleep disturbance in the last six months (BD-Control) participated in the study...
January 5, 2017: Journal of Psychiatric Research
So Kirino, Takefumi Suzuki, Hiroyoshi Takeuchi, Masaru Mimura, Hiroyuki Uchida
While positron emission tomography (PET) studies have provided invaluable data on antipsychotic effects, selection bias remains a serious concern. A systematic review of PET studies that measured dopamine D2 receptor blockade with antipsychotics was conducted to examine their inclusion/exclusion criteria, using PubMed, EMBASE, and (last search, September 2016). PET studies were included if they measured D2 receptor occupancy in patients with schizophrenia and included introduction of antipsychotic treatment or antipsychotic regimen change in a systematic manner...
January 5, 2017: Journal of Psychiatric Research
Camélia Laglaoui Bakhiyi, Isabelle Jaussent, Séverine Beziat, Renaud Cohen, Catherine Genty, Jean-Pierre Kahn, Marion Leboyer, Pascal Le Vaou, Sébastien Guillaume, Philippe Courtet
BACKGROUND: The influence of life events on suicidal behavior remains inconclusive, while reasons for living (RFL) may be protective. OBJECTIVES: To analyze the association between positive and negative life events and suicidal ideation (SI) and the interaction between life events and RFL on SI. METHOD: Patients with history of suicide attempts (n = 338) underwent a comprehensive clinical evaluation, including SI (Beck's Suicidal Ideation scale), RFL (Reasons for Living Inventory, RFLI) and life events (family, school, student or professional, social, health and religion-related and other life events) during the last twelve months...
January 1, 2017: Journal of Psychiatric Research
Francesco Bartoli, Bernardo Dell'Osso, Cristina Crocamo, Andrea Fiorillo, Terence A Ketter, Trisha Suppes, Massimo Clerici, Giuseppe Carrà
The aim of this systematic review and meta-analysis was testing whether low versus high doses of second-generation antipsychotics (SGAs) are associated with different clinical benefits and harms for the acute treatment of bipolar depression. We included clinical trials comparing different doses of the same SGA monotherapy for bipolar depression. SGAs defined daily doses were used to define high and low doses. Clinical benefit outcomes included improvement, response and remission rates on Montgomery-Asberg Depression Rating Scale...
January 1, 2017: Journal of Psychiatric Research
Rahim Mohd Nabil Fikri, A Talib Norlelawati, Abdul Rahim Nour El-Huda, Mohd Noor Hanisah, Abdullah Kartini, Kuzaifah Norsidah, Abdullah Nor Zamzila
The epigenetic changes of RELN that are involved in the development of dopaminergic neurons may fit the developmental theory of schizophrenia. However, evidence regarding the association of RELN DNA methylation with schizophrenia is far from sufficient, as studies have only been conducted on a few limited brain samples. As DNA methylation in the peripheral blood may mirror the changes taking place in the brain, the use of peripheral blood for a DNA methylation study in schizophrenia is feasible due to the scarcity of brain samples...
January 1, 2017: Journal of Psychiatric Research
Lu Zong, Lin Zhou, Yu Hou, Lulu Zhang, Wei Jiang, Wenwei Zhang, Lijuan Wang, Xia Luo, Shiqing Wang, Cong Deng, Zhizhen Peng, Shufen Li, Jiming Hu, Hu Zhao, Cunyou Zhao
To improve our understanding of the abnormalities and non-Mendelian inheritance characteristics of schizophrenia, this study examined DNA methylation (5mC) and hydroxymethylation (5hmC) in the schizophrenia-associated GABRB2 gene encoding the type A γ-aminobutyric acid receptor β2 subunit. DNAs from the peripheral white blood cells of 279 schizophrenic patients and 256 controls from the Chinese Han population were examined to reveal that the GABRB2 promoter P1-5mC level which was correlated with olanzapine administration, P2-5mC/5hmC level, and Alu-5mC level which was correlated with administration of ziprasidone or oxcarbazepine, were increased in schizophrenic patients...
December 28, 2016: Journal of Psychiatric Research
Jing Xiao, Suzhen Guan, Hua Ge, Ning Tao, Yanxia Zhang, Yu Jiang, Li Ning, Jiwen Liu, Yulong Lian
OBJECTIVE: Little is known about the relationship between changing psychosocial work conditions and suicidality. We examined whether or not changed work stressors and coping resources increase the risk of new-onset suicidal ideation. METHODS: A total of 1384 workers from the Occupational Health Study of Petroleum Industry Workers were included in this study. A baseline evaluation of work-related stress and coping resources was followed by a final evaluation after 2 years...
December 26, 2016: Journal of Psychiatric Research
Ines Wilhelm, Sabine Groch, Andrea Preiss, Susanne Walitza, Reto Huber
Social anxiety disorder (SAD) is one of the most prevalent psychiatric diseases typically emerging during childhood and adolescence. Biological vulnerabilities such as a protracted maturation of prefrontal cortex functioning together with heightened reactivity of the limbic system leading to increased emotional reactivity are discussed as factors contributing to the emergence and maintenance of SAD. Sleep slow wave activity (SWA, 0.75-4.5 Hz) and sleep spindle activity (9-16 Hz) reflect processes of brain maturation and emotion regulation...
December 23, 2016: Journal of Psychiatric Research
Paul H Soloff, Kristy Abraham, Karthik Ramaseshan, Ashley Burgess, Vaibhav A Diwadkar
Emotion dysregulation is a core characteristic of patients with Borderline Personality Disorder (BPD), and is often attributed to an imbalance in fronto-limbic network function. Hyperarousal of amygdala, especially in response to negative affective stimuli, results in affective interference with cognitive processing of executive functions. Clinical consequences include the impulsive-aggression, suicidal and self-injurious behaviors which characterize BPD. Dysfunctional interactions between amygdala and its network targets have not been well characterized during cognitive task performance...
December 22, 2016: Journal of Psychiatric Research
Britta Stapel, Alexandra Kotsiari, Michaela Scherr, Denise Hilfiker-Kleiner, Stefan Bleich, Helge Frieling, Kai G Kahl
The use of antipsychotics carries the risk of metabolic side effects, such as weight gain and new onset type-2 diabetes mellitus. The mechanisms of the observed metabolic alterations are not fully understood. We compared the effects of two atypical antipsychotics, one known to favor weight gain (olanzapine), the other not (aripiprazole), on glucose metabolism. Primary human peripheral blood mononuclear cells (PBMC) were isolated and stimulated with olanzapine or aripiprazole for 72 h. Cellular glucose uptake was analyzed in vitro by 18F-FDG uptake...
December 22, 2016: Journal of Psychiatric Research
Clément Palpacuer, Laurent Gallet, Dominique Drapier, Jean-Michel Reymann, Bruno Falissard, Florian Naudet
There is a long-standing and very active debate regarding which psychotherapeutic intervention should be used in depressive disorders. However, the effects of psychotherapies may result majorly from non-specific factors rather than from specific factors related to the type of psychotherapeutic intervention. We performed a systematic review and meta-analysis on aggregated data to understand how the effects of different psychotherapies are impacted by non-specific factors. We included randomized controlled trials that assessed the efficacy of psychotherapeutic interventions in the treatment of adult depressive disorders...
December 22, 2016: Journal of Psychiatric Research
Victor Blüml, Marco Helbich, Michael Mayr, Roland Turnwald, Benjamin Vyssoki, Ute Lewitzka, Sebastian Hartung, Paul L Plener, Jörg M Fegert, Nestor D Kapusta
Suicides account for over one million deaths per year worldwide with depression among the most important risk factors. Epidemiological research into the relationship between antidepressant utilization and suicide mortality has shown heterogeneous and contradictory results. Different methodological approaches and limitations could at least partially explain varying results. This is the first study assessing the association of suicide mortality and antidepressant sales across Germany using complex statistical approaches in order to control for possible confounding factors including spatial dependency of data...
December 13, 2016: Journal of Psychiatric Research
Wenjun Li, Yang Wang, B Douglas Ward, Piero G Antuono, Shi-Jiang Li, Joseph S Goveas
Prior studies have demonstrated dysfunctions within the core neurocognitive networks (the executive control [ECN], default mode [DMN] and salience [SN] networks) in late-life depression (LLD). Whether inter-network dysfunctional connectivity is present in LLD, and if such disruptions are associated with core symptom dimensions is unknown. A cross-sectional resting-state functional connectivity magnetic resonance imaging investigation was conducted of LLD (n = 39) and age- and gender-equated healthy comparison (HC) (n = 29) participants...
December 12, 2016: Journal of Psychiatric Research
Jung-Yoon Heo, Kiwon Kim, Maurizio Fava, David Mischoulon, George I Papakostas, Min-Ji Kim, Dong Jun Kim, Kyung-Ah Judy Chang, Yunhye Oh, Bum-Hee Yu, Hong Jin Jeon
Smartphones deliver light to users through Light Emitting Diode (LED) displays. Blue light is the most potent wavelength for sleep and mood. This study investigated the immediate effects of smartphone blue light LED on humans at night. We investigated changes in serum melatonin levels, cortisol levels, body temperature, and psychiatric measures with a randomized, double-blind, cross-over, placebo-controlled design of two 3-day admissions. Each subject played smartphone games with either conventional LED or suppressed blue light from 7:30 to 10:00PM (150 min)...
December 12, 2016: Journal of Psychiatric Research
Simon J Evans, Christine M Bassis, Robert Hein, Shervin Assari, Stephanie A Flowers, Marisa B Kelly, Vince B Young, Vicky E Ellingrod, Melvin G McInnis
The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. We aimed to elucidate the complement of the gut-microbiome community for individuals with bipolar disorder relative to controls; and test for relationships with burden of disease measures. We compared the stool microbiome from individuals with bipolar disorder (n = 115) and control subjects (n = 64) using 16S ribosomal RNA (rRNA) gene sequence analysis...
December 10, 2016: Journal of Psychiatric Research
Olga Santesteban-Echarri, María A Ramos-Olazagasti, Ruth E Eisenberg, Chiaying Wei, Héctor R Bird, Glorisa Canino, Cristiane S Duarte
BACKGROUND: Parental warmth (PW) has a strong influence on child development and may precede the onset of psychiatric disorders in children. PW is interconnected with other family processes (e.g., coercive discipline) that may also influence the development of psychiatric disorders in children. We prospectively examined the association between PW and child psychiatric disorders (anxiety, major depression disorder, ADHD, disruptive behavior disorders) over the course of three years among Puerto Rican youth, above and beyond the influence of other family factors...
December 9, 2016: Journal of Psychiatric Research
Laura E Watkins, Lauren M Sippel, Robert H Pietrzak, Rani Hoff, Ilan Harpaz-Rotem
Aggression and suicidality are two serious public health concerns among U.S. veterans that can co-occur and share many overlapping risk factors. The current study aims to elucidate the contribution of posttraumatic stress disorder (PTSD) symptom clusters defined by a five-factor model and alcohol misuse in predicting aggression and suicide attempts among veterans entering residential treatment for PTSD. Participants were 2570 U.S. veterans across 35 Veterans Health Administration sites. Multinomial logistic regression models were used to identify correlates of aggression only (n = 1471; 57...
December 9, 2016: Journal of Psychiatric Research
E S Ershova, E M Jestkova, I V Chestkov, L N Porokhovnik, V L Izevskaya, S I Kutsev, N N Veiko, G Shmarina, O Dolgikh, S V Kostyuk
Oxidative DNA damage has been proposed as one of the causes of schizophrenia (SZ), and post mortem data indicate a dysregulation of apoptosis in SZ patients. To evaluate apoptosis in vivo we quantified the concentration of plasma cell-free DNA (cfDNA index, determined using fluorescence), the levels of 8-oxodG in cfDNA (immunoassay) and lymphocytes (FL1-8-oxodG index, flow cytometry) of male patients with acute psychotic disorders: paranoid SZ (total N = 58), schizophreniform (N = 11) and alcohol-induced (N = 14) psychotic disorder, and 30 healthy males...
December 8, 2016: Journal of Psychiatric Research
Jie Xu, Jessica A Harper, Erin A Van Enkevort, Kelsey Latimer, Urszula Kelley, Carrie J McAdams
Anorexia nervosa (AN) is an illness that frequently begins during adolescence and involves weight loss. Two groups of adolescent girls (AN-A, weight-recovered following AN) and (HC-A, healthy comparison) completed a functional magnetic resonance imaging task involving social evaluations, allowing comparison of neural activations during self-evaluations, friend-evaluations, and perspective-taking self-evaluations. Although the two groups were not different in their whole-brain activations, anxiety and body shape concerns were correlated with neural activity in a priori regions of interest...
December 5, 2016: Journal of Psychiatric Research
Helena M Abelaira, Gislaine Z Réus, Zuleide M Ignácio, Maria Augusta B Dos Santos, Airam B de Moura, Danyela Matos, Júlia P Demo, Júlia B I da Silva, Monique Michels, Mariane Abatti, Beatriz Sonai, Felipe Dal Pizzol, André F Carvalho, João Quevedo
Recent studies show that activation of the mTOR signaling pathway is required for the rapid antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists. A relationship between mTOR kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded protein response (UPR) has been shown. We evaluate the effects of ketamine administration on the mTOR signaling pathway and proteins of UPR in the prefrontal cortex (PFC), hippocampus, amygdala and nucleus accumbens, after the inhibiton of mTOR signaling in the PFC...
December 3, 2016: Journal of Psychiatric Research
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