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Journal of Psychiatric Research

Li Ren, Jie Deng, Su Min, Lihua Peng, Qinbin Chen
No abstract text is available yet for this article.
November 5, 2018: Journal of Psychiatric Research
Gabriel Santana da Rosa, Gustavo Santos Andrades, Arthur Caye, Maria Paz Hidalgo, Melissa Alves Braga de Oliveira, Luísa K Pilz
We aimed to investigate the influence of media portrayals of suicide on adolescents' mood, focusing on the case of 13 Reasons Why, a webseries that raised concerns for approaching suicide explicitly for an audience mostly composed of adolescents. There is already evidence of an increase in suicide-related Internet searches shortly following its release. Our study included 7004 individuals aged 12-18 years. Participants were recruited through posts on 13 Reasons Why-themed social media groups. Volunteers filled an online questionnaire made available throughout May 2017 (54-71 days after the show was released)...
October 30, 2018: Journal of Psychiatric Research
Joshua D Rosenblat, Yena Lee, Rodrigo B Mansur, Elisa Brietzke, Roger S McIntyre
No abstract text is available yet for this article.
October 29, 2018: Journal of Psychiatric Research
Khalil El Asmar, Bruno Fève, Romain Colle, Séverine Trabado, Céline Verstuyft, Florence Gressier, Albane Vievard, Emmanuel Haffen, Mircea Polosan, Florian Ferreri, Bruno Falissard, Philippe Chanson, Laurent Becquemont, Emmanuelle Corruble
BACKGROUND: Metabolic syndrome (MetS) is a major public health issue. We assessed whether early weight gain predicts later MetS in depressed patients treated with antidepressants. METHODS: In the 6-month prospective METADAP cohort, 260 non-overweight patients with a Major Depressive Disorder (MDD) and a current Major Depressive Episode (MDE) were assessed for early weight gain (>5%) after one month of treatment, and for the later incidence of MetS after three and six months of treatment...
October 28, 2018: Journal of Psychiatric Research
Rodrigo B Mansur, Gabriel R Fries, Mehala Subramaniapillai, Sophia Frangou, Fernanda G De Felice, Natalie Rasgon, Bruce McEwen, Elisa Brietzke, Roger S McIntyre
Preclinical studies implicate insulin signaling as a modulator of dopamine transmission, but human data is currently limited. We hypothesize that changes in the expression of insulin receptor-related genes in the post-mortem brain tissue of patients with mood and psychotic disorders mediate the expression of dopamine regulation-related genes. From a database containing microarray data from the post-mortem dorsolateral prefrontal cortex (dlPFC) (healthy controls [HC]: n = 209; patients: n = 321) and hippocampus (HC: n = 180; patients: n = 196), we conducted a hypothesis-driven analysis through the a priori selection of 12 dopamine- and 3 insulin-related genes...
October 27, 2018: Journal of Psychiatric Research
Ana E Sheehan, Rachel F L Walsh, Richard T Liu
The current study examined racial/ethnic differences in utilization of mental health services in a nationally representative sample of suicidal adults. Data were extracted from the National Survey on Drug Use and Health (NSDUH) from 2009 to 2016. Participants consisted of adults with severe suicidal ideation and/or behavior in the past 12 months (unweighted n = 17,338). Multivariate logistic regression analyses were conducted to assess racial/ethnic differences in mental health treatment utilization after adjusting for health insurance status, family income, age, sex, and major depression...
October 26, 2018: Journal of Psychiatric Research
Avash Das, Bhaskar Roy, Guido Schwarzer, Michael G Silverman, Olivia Ziegler, Dhrubajyoti Bandyopadhyay, Lisa Liang Philpotts, Shirshendu Sinha, James A Blumenthal, Saumya Das
BACKGROUND: Depression independently predicts poor outcomes in heart failure (HF) patients, including increased mortality, morbidity and 30-day re-hospitalization. In this network meta-analysis, we compared different interventions designed to treat depression in HF. MATERIALS AND METHODS: Electronic searches were conducted using Ovid MEDLINE, EMBASE, CINAHL, Web of Science, and PsycINFO up to November 2016. Included randomized clinical trials (RCTs) compared interventions (Exercise therapy (ET), cognitive behavioral therapy (CBT) or antidepressant (AD) medications) for depression in heart failure patients...
October 25, 2018: Journal of Psychiatric Research
Gisela M Sandoval, Sehoon Shim, David S Hong, Amy S Garrett, Eve-Marie Quintin, Matthew J Marzelli, Swetapadma Patnaik, Amy A Lightbody, Allan L Reiss
Abnormal brain development and cognitive dysfunction have been reported both in children and in adults with fragile X syndrome (FXS). However, few studies have examined neuroanatomical abnormalities in FXS during adolescence. In this study we focus on adolescent subjects with FXS (N = 54) as compared to age- and sex-matched subjects with idiopathic intellectual disability (Comparison Group) (N = 32), to examine neuroanatomical differences during this developmental period. Brain structure was assessed with voxel-based morphometry and independent groups t-test in SPM8 software...
October 25, 2018: Journal of Psychiatric Research
Yannick Stephan, Angelina R Sutin, Martina Luchetti, Pauline Caille, Antonio Terracciano
Alzheimer's disease (AD) polygenic risk score (PGS) is associated with lower cognitive functioning even among older individuals without dementia. We tested the hypothesis that personality traits mediate the association between AD genetic risk and cognitive functioning. Participants (N > 7,000, aged 50-99 years old) from the Health and Retirement Study were genotyped and completed personality and cognition tests at baseline. Cognition was assessed again four years later. Bootstrap analysis revealed that a higher AD polygenic risk score was associated with lower cognitive scores at baseline through higher neuroticism, lower conscientiousness, and lower levels of the industriousness facet of conscientiousness...
October 23, 2018: Journal of Psychiatric Research
Gabriela Xavier, Letícia M Spindola, Vanessa K Ota, Carolina M Carvalho, Pawan Kumar Maurya, Priscila F Tempaku, Patricia N Moretti, Diego R Mazotti, João Ricardo Sato, Elisa Brietzke, Euripedes Constantino Miguel, Rodrigo Grassi-Oliveira, Jair Mari, Rodrigo A Bressan, Ary Gadelha, Pedro M Pan, Sintia Iole Belangero
Child maltreatment (CM) is a global issue with serious lifelong consequences. In fact, maltreatment during childhood might be an important risk factor for the development of psychiatric disorders. Furthermore, previous studies showed a strong relationship between telomere length (TL) and early life stress. Considering that only a few studies have evaluated this relationship in children and that even fewer considered the sex as a possible moderator, we investigated whether TL in the blood of both children and adolescents was associated with psychopathology and with a history of CM, and whether these associations were moderated by the sex...
October 22, 2018: Journal of Psychiatric Research
Steven D Targum, Beth R Cameron, Ludvina Ferreira, I David MacDonald
We conducted a 6-week double-blind, placebo-controlled, augmentation study comparing the efficacy and safety of MSI-195 800 mg (a proprietary formulation of S-adenosylmethionine) or placebo added to ongoing antidepressant medication (ADT) in acutely depressed subjects with Major Depressive Disorder (MDD) who had experienced an inadequate response to their ongoing ADT (The Horizon Study, NCT01912196). There were 234 eligible subjects randomized to either MSI-195 (n = 118) or placebo (n = 116)...
October 18, 2018: Journal of Psychiatric Research
Yuta Yoshino, Yu Funahashi, Shunsuke Nakata, Yuki Ozaki, Kiyohiro Yamazaki, Taku Yoshida, Takaaki Mori, Yoko Mori, Shinichiro Ochi, Jun-Ichi Iga, Shu-Ichi Ueno
The neuroprotective effect of ghrelin has recently been reported in Alzheimer's disease (AD). Ghrelin is converted from des-acyl ghrelin to the activated form, acyl ghrelin, by membrane bound o-acyltransferase 4 (MBOAT4), and then binds to growth hormone secretagogue receptor (GHS-R). We examined the levels of plasma acyl/des-acyl ghrelin in 75 AD subjects and age- and sex-matched controls, as well as the DNA methylation and mRNA expression of MBOAT4 and GHS-R in peripheral leukocytes. The acyl ghrelin concentration was significantly higher in AD subjects than in controls (2...
October 18, 2018: Journal of Psychiatric Research
Shufen Li, Qiong Yang, Yu Hou, Tingyun Jiang, Lu Zong, Zhongju Wang, Xia Luo, Wenquan Liang, Hu Zhao, Yuping Ning, Cunyou Zhao
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental illnesses with evidence of significant genetic and environmental etiological elements in their complex etiologies. 5'-Methylcytosine is the main epigenetic DNA modification that mediates the interplay between genetic and environmental components. In humans, most 5'-methylcytosine modifications are observed in CpG-rich regions within the long interspersed nuclear element (LINE-1). LINE-1 is a mobile retrotransposon that comprises ∼17% of the human genome, and its methylation levels are highly correlated with global DNA methylation levels...
October 10, 2018: Journal of Psychiatric Research
Omer Linkovski, Jordana Zwerling, Elisabeth Cordell, Danae Sonnenfeld, Henry Willis, Christopher N La Lima, Colleen Baker, Rassil Ghazzaoui, Robyn Girson, Catherine Sanchez, Brianna Wright, Mason Alford, Andrea Varias, Maria Filippou-Frye, Hanyang Shen, Booil Jo, Lee Shuer, Randy O Frost, Carolyn I Rodriguez
Hoarding disorder is characterized by difficulty parting with possessions and by clutter that impairs the functionality of living spaces. Cognitive behavioral therapy conducted by a therapist (individual or in a group) for hoarding symptoms has shown promise. For those who cannot afford or access the services of a therapist, one alternative is an evidence-based, highly structured, short-term, skills-based group using CBT principles but led by non-professional facilitators (the Buried in Treasures [BIT] Workshop)...
October 5, 2018: Journal of Psychiatric Research
Kai Wang, Deepthi S Varma, Mattia Prosperi
BACKGROUND: There are a growing number of mobile apps available for monitoring and management of mental health symptoms or disorders. However, clinically validated evidence for most of them is unclear; their benefits to patients on long term use are thus debatable. OBJECTIVE: This updated review aimed to systematically appraise the available research evidence of the efficacy and acceptability of mobile apps for mental health in all ages. METHODS: A comprehensive literature search (May 2013 to December 2017) in PubMed, Cochrane Library, EMBASE, Web of Science, and Google Scholar was conducted...
October 5, 2018: Journal of Psychiatric Research
Francisca Taciana Sousa Rodrigues, Marcos Romário Matos de Souza, Camila Nayane de Carvalho Lima, Francisco Eliclécio Rodrigues da Silva, Deiziane Viana da Silva Costa, Cláudio Costa Dos Santos, Fábio Miyajima, Francisca Cléa F de Sousa, Silvânia Maria Mendes Vasconcelos, Tatiana Barichello, João Quevedo, Michael Maes, David F de Lucena, Danielle Macedo
Major depressed patients show increased bacterial translocation with elevated plasma levels of lipopolysaccharide (LPS), which may trigger immune-inflammatory and neuro-oxidative responses. Recently, an animal model based on chronic LPS administration was developed which was associated with long-lasting depressive-like and neuro-oxidative alterations in female mice. The aim of the current study was to investigate behavioral, neuroimmune and neuroprogressive alterations in female mice 6 weeks after LPS chronic exposure...
October 5, 2018: Journal of Psychiatric Research
James Reich, Alan Schatzberg, Kevin Delucchi
BACKGROUND: Treatment resistant disorders are a significant clinical problem. Impediments to good outcome need to be identified and addressed. Personality pathology has been hypothesized to be one such factor in panic disorder. There is no consensus as to the effects of personality pathology on the outcome of panic disorder. This study examined empirical evidence. The hypothesis was that personality pathology would cause poorer outcome of panic disorder. METHODS: A literature search was conducted that winnowed 2627 articles down to 27 based on 1) longitudinal design; 2) validated measures of personality; 3) validated outcome measures; and 4) the presence of effect size or data to calculate effect size...
October 5, 2018: Journal of Psychiatric Research
Bárbara Duarte-Abritta, Mirta F Villarreal, Carolina Abulafia, David Loewenstein, Rosie E Curiel Cid, Mariana N Castro, Ezequiel Surace, Stella-Maris Sánchez, Daniel E Vigo, Silvia Vázquez, Charles B Nemeroff, Gustavo Sevlever, Salvador M Guinjoan
The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting early structural and functional traits associated with the disorder, we sought to characterize cortical thickness and subcortical grey matter volume, cerebral metabolism, and amyloid deposition in persons at risk for LOAD in comparison with a similar group without family history of AD...
October 5, 2018: Journal of Psychiatric Research
Julia Y Gorday, Megan L Rogers, Thomas E Joiner
BACKGROUND: Pathological worry is defined as worry that is excessive, pervasive, and uncontrollable. Although pathological worry is related to depression, anxiety, and suicidal ideation, less is understood about what specific features of worry confer risk for these mental health conditions. The current study examined associations between four characteristics of worry-frequency, duration, controllability, and content-and self-reported symptoms of depression, anxiety, suicidal ideation, and lifetime suicide attempts...
October 4, 2018: Journal of Psychiatric Research
Leila Jahangard, Ali Sadeghi, Mohammad Ahmadpanah, Edith Holsboer-Trachsler, Dena Sadeghi Bahmani, Mohammad Haghighi, Serge Brand
BACKGROUND: Extant literature shows that adjuvant omega-3-polyunsaturated fatty acids (O3PUFAs) to a standard antidepressant medication impacts favorably on symptoms of depression in participants with major depressive disorders (MDD). The aim of the present study was to investigate, if and to what extent compared to placebo adjuvant O3PUFAs had a favorable impact on symptoms of depression, anxiety, sleep and emotion regulation among outpatients with MDD. METHOD: A total of 50 outpatients (mean age: M = 42...
October 1, 2018: Journal of Psychiatric Research
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