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Journal of Psychiatric Research

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https://www.readbyqxmd.com/read/28433949/the-dimensional-structure-of-psychopathology-in-22q11-2-deletion-syndrome
#1
Maria Niarchou, Tyler M Moore, Sunny X Tang, Monica E Calkins, Donna M McDonald-McGuinn, Elaine H Zackai, Beverly S Emanuel, Ruben C Gur, Raquel E Gur
BACKGROUND: 22q11.2 Deletion Syndrome (22q11.2DS) is one of the strongest known genetic risk factors for developing schizophrenia. Individuals with 22q11.2DS have high rates of neurodevelopmental disorders in childhood, while in adulthood ∼25% develop schizophrenia. Similar to the general population, high rates of comorbidity are common in 22q11.2DS. Employing a dimensional approach where psychopathology is examined at the symptom-level as complementary to diagnostic categories in a population at such high genetic risk for schizophrenia can help gain a better understanding of how psychopathology is structured as well as its genetic underpinnings...
April 15, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28445800/adjunctive-celecoxib-for-schizophrenia-a-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#2
Wei Zheng, Dong-Bin Cai, Xin-Hu Yang, Gabor S Ungvari, Chee H Ng, Norbert Müller, Yu-Ping Ning, Yu-Tao Xiang
Neuroinflammation has been implicated in the neurobiological pathways of schizophrenia. This meta-analysis evaluated the efficacy and tolerability of adjunctive celecoxib as a noncompetitive anti-inflammation drug in treating schizophrenia. Data were searched, extracted, checked and entered into the RevMan (version 5.3) software by two independent investigators. Standardized/weighted mean differences (SMDs/WMDs), risk ratio (RR) and their 95% confidence intervals (CIs) were calculated, as appropriate. Included were 8 randomized controlled trials (RCTs) with a total of 626 patients with schizophrenia including 316 (50...
April 14, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28433860/cognitive-intrusion-of-pain-and-catastrophic-thinking-independently-explain-interference-of-pain-in-the-activities-of-daily-living
#3
Mojtaba Talaei-Khoei, Paul T Ogink, Ragini Jha, David Ring, Neal Chen, Ana-Maria Vranceanu
Patients with musculoskeletal illness often report that pain interferes with their ability to engage in activities of daily living. Catastrophic thinking is consistently depicted as an important cognitive factor that hinders adjustment to pain. Current research has also shown that pain negatively impacts an individual's ability to maintain attention on the task at hand. While a measure of the experience of cognitive intrusion of pain (ECIP) has been recently developed to quantify the extent of that impact, little research has explored this issue in everyday settings...
April 14, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28412601/a-systematic-review-of-factors-associated-with-service-user-satisfaction-with-psychiatric-inpatient-services
#4
REVIEW
Sarah Woodward, Katherine Berry, Sandra Bucci
BACKGROUND: Satisfaction is seen as an indicator of the quality of mental health services and has been related to outcomes and compliance with treatment. The current review seeks to examine the factors relating to satisfaction with inpatient services. METHOD: A search was conducted of PsycInfo, Web of Science, Cinahl, Embase and Medline databases. Screening resulted in 32 papers being included in the review. Papers were subject to quality assessment using the Mixed Methods Appraisal Tool (MMAT)...
April 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28412600/dna-methylation-changes-at-trem2-intron-1-and-trem2-mrna-expression-in-patients-with-alzheimer-s-disease
#5
Yuki Ozaki, Yuta Yoshino, Kiyohiro Yamazaki, Tomoko Sao, Yoko Mori, Shinichiro Ochi, Taku Yoshida, Takaaki Mori, Jun-Ichi Iga, Shu-Ichi Ueno
OBJECTIVES: Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. We previously reported that TREM2 mRNA is highly expressed in leukocytes of AD patients compared to those in healthy controls. However, the mechanism of TREM2 expression change is still not known. In this study, we examined the involvement of the DNA methylation status of TREM2 in its high gene expression...
April 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28412602/secondary-outcomes-from-the-pediatric-obsessive-compulsive-disorder-treatment-study-ii
#6
Christine A Conelea, Robert R Selles, Kristen G Benito, Michael M Walther, Jason T Machan, Abbe M Garcia, Jeffrey Sapyta, Sarah Morris, Martin Franklin, Jennifer B Freeman
The Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II) investigated the benefit of serotonin reuptake inhibitor (SRI) augmentation with cognitive behavioral therapy (CBT). Primary outcomes focused on OCD symptom change and indicated benefit associated with a full course of CBT. Given that the majority of youth with OCD suffer from significant comorbid symptoms and impaired quality of life, the current study examined POTS II data for effects on secondary outcomes. Participants were 124 youth ages 7-17 years with a primary diagnosis of OCD who were partial responders to an adequate SRI trial...
April 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28410485/impact-of-posttraumatic-stress-symptom-dimensions-on-psychophysiological-reactivity-to-threat-and-reward
#7
Lynne Lieberman, Stephanie M Gorka, Carter J Funkhouser, Stewart A Shankman, K Luan Phan
Posttraumatic stress symptoms (PTSS) are associated with significant distress and impairment. Research has therefore focused on identifying neurobehavioral deficits that contribute to the pathophysiology of PTSS. One issue that has contributed to difficulty in identifying these deficits is the highly heterogeneous nature of PTSS. PTSS is comprised of four, factor analytically distinct dimensions of symptoms - re-experiencing, avoidance, hyperarousal, and negative cognitions and mood. It is therefore unlikely that there is one single mechanism that accounts for all of PTSS and elucidating neurobehavioral deficits associated with specific PTSS symptom dimensions may better inform clinical prevention and intervention efforts...
April 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28391178/mirtazapine-attenuates-cocaine-seeking-in-rats
#8
Susana Barbosa-Méndez, Phillipe Leff, Adriana Arías-Caballero, Ricardo Hernández-Miramontes, Gerardo Heinze, Alberto Salazar-Juárez
BACKGROUND: Relapse to cocaine use is a major problem in the clinical treatment of cocaine addiction. Antidepressants have been studied for their therapeutic potential to treat cocaine use disorder. Research has suggested that antidepressants attenuate both drug craving and the re-acquisition of drug-seeking and drug-taking behaviors. This study examined the efficacy of mirtazapine, an antidepressant/anxiolytic, in decreasing cocaine seeking in rats. METHODS: We used the cocaine self-administration paradigm to assess the effects of mirtazapine on rats trained to self-administer cocaine or food under a fixed-ratio schedule...
April 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28433948/metabolic-syndrome-in-subjects-with-bipolar-disorder-and-major-depressive-disorder-in-a-current-depressive-episode-population-based-study-metabolic-syndrome-in-current-depressive-episode
#9
Fernanda Pedrotti Moreira, Karen Jansen, Taiane de Azevedo Cardoso, Thaíse Campos Mondin, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Jean Pierre Oses, Carolina David Wiener
OBJECTIVE: To assess the differences in the prevalence of the metabolic syndrome (MetS) and their components in young adults with bipolar disorder (BD) and major depressive disorder (MDD) in a current depressive episode. METHODS: This was a cross-sectional study with young adults aged 24-30 years old. Depressive episode (bipolar or unipolar) was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III)...
April 2, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28411417/heart-rate-variability-and-cordance-in-rapid-eye-movement-sleep-as-biomarkers-of-depression-and-treatment-response
#10
Marcel A Pawlowski, Mary Gazea, Bastian Wollweber, Martin Dresler, Florian Holsboer, Martin E Keck, Axel Steiger, Marek Adamczyk, Thorsten Mikoteit
OBJECTIVES: The relevance of rapid eye movement (REM) sleep in affective disorders originates from its well-known abnormalities in depressed patients, who display disinhibition of REM sleep reflected by increased frequency of rapid eye movements (REM density). In this study we examined whether heart rate variability (HRV) and prefrontal theta cordance, both derived from REM sleep, could represent biomarkers of antidepressant treatment response. METHODS: In an open-label, case-control design, thirty-three in-patients (21 females) with a depressive episode were treated with various antidepressants for four weeks...
April 2, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28407508/stress-related-telomere-length-in-children-a-systematic-review
#11
REVIEW
Bruno Messina Coimbra, Carolina Muniz Carvalho, Patricia Natalia Moretti, Marcelo Feijó Mello, Sintia I Belangero
Telomeres are repetitive DNA sequences at the ends of chromatids that shorten following each cell replication. Once telomeres reach a critical length, DNA defense mechanisms can direct cells to either a state of arrest (senescence) or apoptosis. Stress induced by adversity is a probable cause of accelerated telomere shortening from an early age. However, few studies have examined the association between stress and telomere length in children, and it remains unclear whether young individuals may show signs of cellular aging early in life...
April 2, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28390221/overarousal-as-a-mechanism-of-the-relation-between-rumination-and-suicidality
#12
Megan L Rogers, Matthew E Schneider, Raymond P Tucker, Keyne C Law, Michael D Anestis, Thomas E Joiner
Rumination, particularly brooding, is associated with suicidal ideation and attempts; however, mechanisms of these associations have not been identified. The present study examined manifestations of overarousal-agitation, insomnia, and nightmares-that have been linked to both rumination and suicide as indirect indicators of the link between brooding and suicidal ideation/attempts. A sample of 492 psychiatric outpatients (64.2% female), aged 17-65 years (M = 26.75, SD = 10.32), completed self-report measures before their intake appointments with a therapist...
April 2, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28414929/association-of-physical-injury-and-mental-health-results-from-the-national-comorbidity-survey-adolescent-supplement
#13
Jessica L Jenness, Cordelie E Witt, D Alex Quistberg, Brian D Johnston, Ali Rowhani-Rahbar, Jessica L Mackelprang, Katie A McLaughlin, Monica S Vavilala, Frederick P Rivara
Nonfatal injury is common among adolescents in the U.S., but little is known about the bi-directional associations between injury and mental health. Utilizing a nationally representative sample of U.S. adolescents, we examined 1) associations between lifetime mental health history and subsequent injury; 2) concurrent associations between injury and mental health; and 3) associations between injury and subsequent mental disorders. Data were drawn from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A), a national survey of adolescents aged 13 through 17 years (N = 10,123)...
April 1, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28364595/hippocampal-development-in-youth-with-a-history-of-childhood-maltreatment
#14
Casey Paquola, Maxwell R Bennett, Sean N Hatton, Daniel F Hermens, Inge Groote, Jim Lagopoulos
Childhood maltreatment (CM) is associated with enhanced risk of psychiatric illness and reduced subcortical grey matter in adulthood. The hippocampus and amygdala, due to their involvement in stress and emotion circuitries, have been subject to extensive investigations regarding the effect of CM. However, the complex relationship between CM, subcortical grey matter and mental illness remains poorly understood partially due to a lack of longitudinal studies. Here we used segmentation and linear mixed effect modelling to examine the impact of CM on hippocampal and amygdala development in young people with emerging mental illness...
March 27, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28376408/impact-of-the-neural-correlates-of-stress-and-cue-reactivity-on-stress-related-binge-eating-in-the-natural-environment
#15
Sarah Fischer, Lauren Breithaupt, Joseph Wonderlich, Margaret L Westwater, Ross D Crosby, Scott G Engel, James Thompson, Jason Lavender, Stephen Wonderlich
Women with symptoms of bulimia nervosa (BN) exhibit decreased response to visual food cues in several limbic and frontal regions compared to controls. Stress causes decreased blood oxygenation level dependent (BOLD) response in these regions in non-clinical samples; there is a lack of data on this topic in BN. This study examined the impact of individual differences in neural reactivity to palatable food cues following acute stress on stress-binge trajectories in everyday life. 16 women with BN symptoms viewed palatable food cues prior to and immediately following an acute stress induction in the scanner...
March 25, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28376409/cognitive-training-to-improve-memory-in-individuals-undergoing-electroconvulsive-therapy-negative-findings
#16
Jimmy Choi, Yuanjia Wang, Tianshu Feng, Joan Prudic
Although electroconvulsive therapy (ECT) remains the most effective treatment for severe depression, some patients report persistent memory problems following ECT that impact their quality of life and their willingness to consent to further ECT. While cognitive training has been shown to improve memory performance in various conditions, this approach has never been applied to help patients regain their memory after ECT. In a double-blind study, we tested the efficacy of a new cognitive training program called Memory Training for ECT (Mem-ECT), specifically designed to target anterograde and retrograde memory that can be compromised following ECT...
March 24, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28384542/gene-expression-in-blood-of-children-and-adolescents-mediation-between-childhood-maltreatment-and-major-depressive-disorder
#17
Leticia Maria Spindola, Pedro Mario Pan, Patricia Natalia Moretti, Vanessa Kiyomi Ota, Marcos Leite Santoro, Hugo Cogo-Moreira, Ary Gadelha, Giovanni Salum, Gisele Gus Manfro, Jair Jesus Mari, Helena Brentani, Rodrigo Grassi-Oliveira, Elisa Brietzke, Euripedes Constantino Miguel, Luis Augusto Rohde, João Ricardo Sato, Rodrigo Affonseca Bressan, Sintia Iole Belangero
Investigating major depressive disorder (MDD) in childhood and adolescence can help reveal the relative contributions of genetic and environmental factors to MDD, since early stages of disease have less influence of illness exposure. Thus, we investigated the mRNA expression of 12 genes related to the hypothalamic-pituitary-adrenal (HPA) axis, inflammation, neurodevelopment and neurotransmission in the blood of children and adolescents with MDD and tested whether a history of childhood maltreatment (CM) affects MDD through gene expression...
March 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28343067/reading-problems-and-major-mental-disorders-co-occurrences-and-familial-overlaps-in-a-swedish-nationwide-cohort
#18
Martin Cederlöf, Barbara Maughan, Henrik Larsson, Brian M D'Onofrio, Robert Plomin
Reading problems often co-occur with ADHD and conduct disorder. However, the patterns of co-occurrence and familial overlap between reading problems and other psychiatric disorders have not been systematically explored. We conducted a register-based cohort study including 8719 individuals with reading problems and their siblings, along with matched comparison individuals. Conditional logistic regressions estimated risks for ADHD, autism, obsessive-compulsive disorder, anorexia nervosa, schizophrenia, bipolar disorder, depression, substance use disorder, and violent/non-violent criminality in individuals with reading problems and their siblings...
March 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28433950/an-electrocortical-investigation-of-emotional-face-processing-in-military-related-posttraumatic-stress-disorder
#19
Julia A DiGangi, Katie L Burkhouse, Darrin M Aase, Joseph M Babione, Christopher Schroth, Amy E Kennedy, Justin E Greenstein, Eric Proescher, K Luan Phan
PTSD is a disorder of emotion dysregulation. Although much work has intended to elucidate the neural underpinnings of the disorder, much remains unknown about the neurobiological substrates of emotion dysregulation in PTSD. In order to assess the relationship between a neural measure of attention to emotion (i.e. the late positive potential; LPP) and PTSD symptoms, EEG was recorded and examined as a potential predictor of military-related PTSD symptoms in a sample of 73 OEF/OIF/OND veterans. Results revealed that higher PTSD symptoms were related to an attenuated LPP response to angry facial expressions...
March 20, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28343068/the-role-of-trail-in-fatigue-induced-by-repeated-stress-from-radiotherapy
#20
Li Rebekah Feng, Simeng Suy, Sean P Collins, Leorey N Saligan
Fatigue is one of the most common and debilitating side effects of cancer and cancer treatment, and yet its etiology remains elusive. The goal of this study is to understand the role of chronic inflammation in fatigue following repeated stress from radiotherapy. Fatigue and non-fatigue categories were assessed using ≥ 3-point change in Functional Assessment of Cancer Therapy-Fatigue questionnaire (FACT-F) administered to participants at baseline/before radiotherapy and one year post-radiotherapy. Whole genome microarray and cytokine multiplex panel were used to examine fatigue-related transcriptome and serum cytokine changes, respectively...
March 20, 2017: Journal of Psychiatric Research
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