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https://www.readbyqxmd.com/read/29462603/lox-1-receptor-a-potential-link-in-atherosclerosis-and-cancer
#1
REVIEW
Silvana Balzan, Valter Lubrano
Altered production of reactive oxygen species (ROS), causing lipid peroxidation and DNA damage, contributes to the progression of atherosclerosis and cancer. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a lectin-like receptor for oxidized low-density lipoproteins (ox-LDL) primarily expressed in endothelial cells and vasculature-rich organs. LOX-1 receptors is a marker for atherosclerosis, and once activated by ox-LDL or other ligands, stimulates the expression of adhesion molecules, pro-inflammatory signaling pathways and proangiogenic proteins, including NF-kB and VEGF, in vascular endothelial cells and macrophages...
February 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29455005/could-curcumin-protect-the-dendritic-trees-of-the-ca1-neurons-from-shortening-and-shedding-induced-by-chronic-sleep-restriction-in-rats
#2
Ali Noorafshan, Fatemeh Karimi, Ali-Mohammad Kamali, Saied Karbalay-Doust, Mohammad Nami
BACKGROUND AND OBJECTIVE: This study evaluated the effect of chronic sleep restriction (CSR) with or without curcumin (CUR) treatment on dendritic lengths and spines of the CA1 hippocampus using the virtual space-ball method. MATERIALS AND METHODS: Male rats were randomly submitted to nine groups, including distilled water, CUR (100 mg/kg/day), olive oil, CSR plus distilled water, CSR plus CUR, CSR plus olive oil, grid-floor plus distilled water, grid-floor plus CUR, and grid-floor plus olive oil groups...
February 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29455004/role-of-rho-kinase-rock-in-tonic-but-not-phasic-contraction-in-the-frog-stomach-smooth-muscle
#3
Leyla Sahın, Ozge Selin Cevık, Dilan Deniz Koyuncu, Kansu Buyukafsar
AIMS: Rho/Rho-kinase (ROCK) signaling has extensively been shown to take part in mammalian smooth muscle contractions in response to diverse agents yet its role in the contraction of amphibian smooth muscle has not been investigated. Therefore, we aimed to explore any role of this pathway in the contractions of frog stomach smooth. MAIN METHODS: The strips were prepared and suspended in organ baths filled with Ringer solution. Changes in the circular strips of the frog stomach muscle length were recorded isotonically with a force transducer in organ baths...
February 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29455003/combinatorial-strategy-of-epigenetic-and-hormonal-therapies-a-novel-promising-approach-for-treating-advanced-prostate-cancer
#4
Tarek K Motawi, Hebatallah A Darwish, Iman Diab, Maged W Helmy, Mohamed Noureldin
AIMS: Estrogens act as key factors in prostate biology, cellular proliferation and differentiation as well as cancer development and progression. The expression of estrogen receptor (ER)-β appears to be lost during prostate cancer progression through hypermethylation mechanism. Epigenetic drugs such as 5-aza-2'-deoxycytidine (5-AZAC) and Trichostatin A (TSA) showed efficacy in restoring ERβ expression in prostate cancer cells. This study was designed to explore the potential anti-carcinogenic effects resulting from re-expressing ERβ1 using 5-AZAC and/or TSA, followed by its stimulation with Diarylpropionitrile (DPN), a selective ERβ1 agonist, in prostate cancer cell line PC-3...
February 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29455002/the-possible-neuroprotective-effect-of-ellagic-acid-on-sodium-arsenate-induced-neurotoxicity-in-rats
#5
Mehdi Goudarzi, Shivasadat Amiri, Ali Nesari, Azam Hosseinzadeh, Esrafil Mansouri, Saeed Mehrzadi
OBJECTIVE: Arsenic is a well-known environmental contaminant, causing toxicity in different organs. The aim of this study was to investigate the possible neuroprotective effect of ellagic acid (EA) on arsenic-induced neurotoxicity in rats. DESIGN: Animals were divided into five groups. The first group received normal saline (2 ml/kg) for 21 days as control group. Group 2 was orally treated with sodium arsenite (SA, 10 mg/kg) for 21 days. Groups 3 and 4 were orally treated with SA (10 mg/kg) for 7 days prior to EA (10 and 30 mg/kg respectively) treatment and continued up to 21 days simultaneously with SA administration...
February 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29453988/silencing-calreticulin-gene-might-protect-cardiomyocytes-from-angiotensin-ii-induced-apoptosis
#6
Wen Zhang, Zhiyue Liu, Yanmei Zhang, Qinxue Bao, Wenchao Wu, He Huang, Xiaojing Liu
AIMS: Calreticulin (CRT), as a chaperone, contributes to protein folding and quality control cycle. CRT is an important factor regulating Ca 2+ that participates in cell apoptosis. However, the function of CRT in the heart is still controversial. Therefore, we aimed to investigate the potential role of CRT in angiotensin II-induced cardiomyocytes apoptosis. MAIN METHODS: Primary cultured neonatal cardiomyocytes were stimulated with angiotensin II to induce the apoptosis...
February 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29452167/microrna-136-inhibits-proliferation-and-promotes-apoptosis-and-radiosensitivity-of-cervical-carcinoma-through-the-nf-%C3%AE%C2%BAb-pathway-by-targeting-e2f1
#7
Hong-Jie Lu, Pei-Ying Jin, Yao Tang, Shao-Hua Fan, Zi-Feng Zhang, Fang Wang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
AIMS: Several microRNAs (miRs) are expressed aberrantly and associated with progression, tumorigenesis, and prognosis of haematological and solid tumors. The study aimed to identify the effects involved with microRNA-136 (miR-136) on the concurrent enhancement of proliferation, apoptosis and radiosensitivity of cervical carcinoma through the NF-κB signaling pathway by targeting E2F1. MAIN METHODS: Totally 338 patients with cervical carcinoma were recruited in this study...
February 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29452166/metformin-ameliorates-the-progression-of-atherosclerosis-via-suppressing-macrophage-infiltration-and-inflammatory-responses-in-rabbits
#8
Qiangbing Yang, Hongming Yuan, Mao Chen, Jiali Qu, He Wang, Biao Yu, Jiahuan Chen, Shengnan Sun, Xiaochun Tang, Wenzhi Ren
AIMS: The present study aimed to investigate the possible effects of metformin on the progression of atherosclerosis in a rabbit model. MAIN METHODS: Rabbits were randomly divided into three groups (n = 10): the control (Ctrl) group (fed with a chow diet), and two experimental groups, the AS group and the Met group (both received an atherogenic diet). After 2 weeks of acclimatization, the rabbits in the AS and Met groups were given a placebo and metformin, respectively, daily by gavage for 10 weeks...
February 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29452165/the-beneficial-role-of-early-exercise-training-following-stroke-and-possible-mechanisms
#9
REVIEW
Ying Xing, Si-Dong Yang, Fang Dong, Man-Man Wang, Ya-Shuo Feng, Feng Zhang
Exercise training is a regular therapy for stroke patients in clinic. However, whether the early exercise is beneficial for stroke patients is still controversial. The review was performed in databases of OVID, PUBMED, and ISI Web of Science, from respective inception to December 2017. In this review, we summarize the effect of different exercise intensity, initiation time, and style on ischemic stroke. Moreover, the possible mechanism is also discussed. The conclusion is that the voluntary exercise is better in promoting the functional recovery following stroke compared to forced exercise; too early initiated exercise might play a harmful role following stroke, while early initiated exercise might exert benefits after stroke; mild and moderate intensity exercise training could generate better neuroprotection in comparison with high intensity exercise training; early excise training could regulate the process of brain edema, cell apoptosis, oxidative damage, stem cells and other mechanisms in order to exert neuroprotection for brain...
February 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29438662/alendronate-augments-lipid-a-induced-il-1%C3%AE-release-and-smad3-nlrp3-asc-dependent-cell-death
#10
Riyoko Tamai, Yusuke Kiyoura
Alendronate (ALN) is a nitrogen-containing bisphosphonate (NBP) that inhibits bone resorption. NBPs have inflammatory side effects, and ALN augments bacteria-induced interleukin (IL)-1β production. The present study aimed to examine whether ALN induces pyroptosis, a form of cell death associated with IL-1β release, in macrophage-like J774.1 cells incubated with lipid A, a component of gram-negative bacteria. Pretreatment of J774.1 cells with ALN increased lipid A-induced IL-1β production and cell death, but not IL-6 and TNF-α production...
February 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29432760/toxic-effects-of-fluoride-on-organisms
#11
REVIEW
Huan Zuo, Liang Chen, Ming Kong, Lipeng Qiu, Peng Lü, Peng Wu, Yanhua Yang, Keping Chen
Accumulation of excess fluoride in the environment poses serious health risks to plants, animals, and humans. This endangers human health, affects organism growth and development, and negatively impacts the food chain, thereby affecting ecological balance. In recent years, numerous studies focused on the molecular mechanisms associated with fluoride toxicity. These studies have demonstrated that fluoride can induce oxidative stress, regulate intracellular redox homeostasis, and lead to mitochondrial damage, endoplasmic reticulum stress and alter gene expression...
February 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/29432759/bisphenol-a-exposure-disturbs-the-bone-metabolism-an-evolving-interest-towards-an-old-culprit
#12
REVIEW
Zar Chi Thent, Gabriele Ruth Anisah Froemming, Suhaila Muid
Bisphenol A (BPA) (2,2,-bis (hydroxyphenyl) propane), a well-known endocrine disruptor (ED), is the exogenous chemical that mimic the natural endogenous hormone like oestrogen. Due to its extensive exposure to humans, BPA is considered to be a major toxicological agent for general population. Environmental exposure of BPA results in adverse health outcomes including bone loss. BPA disturbs the bone health by decreasing the plasma calcium level and inhibiting the calcitonin secretion. BPA also stimulated differentiation and induced apoptosis in human osteoblasts and osteoclasts...
February 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/29428600/contraction-dependent-tgf-%C3%AE-1-activation-is-required-for-thrombin-induced-remodeling-in-human-airway-smooth-muscle-cells
#13
Zhi-Hui Yao, Hao-Jun Xie, Ya-Lu Yuan, Ya-Ting Huo, Jing Cao, Wen-Yan Lai, Rui-Jun Cai, Yuan-Xiong Cheng
AIMS: Thrombin is a serine proteinase that is not only involved in coagulation cascade, but also mediates a number of biological responses relevant to tissues repair, and induces bronchoconstriction. TGF-β plays a pivotal role in airway remodeling due to its effects on airway smooth muscle proliferation and extracellular matrix (ECM) deposition. Recently, bronchoconstriction itself is found to constitute a form of strain and is highly relevant to asthmatic airway remodeling. However, the underlying mechanisms remain unknown...
February 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29428599/maternal-high-fructose-diet-and-neonatal-immune-challenge-alter-offspring-anxiety-like-behavior-and-inflammation-across-the-lifespan
#14
Syed Hussain F Bukhari, Olivia E Clark, Lauren L Williamson
AIMS: This study examined the interaction between maternal high fructose diet and neonatal inflammation in neonates (P7), juveniles (P26-34) and adults on measures of anxiety-like behavior and cognition. The study aimed to assess the potential synergistic effects of these two forms of early-life inflammation. MAIN METHODS: We fed Sprague-Dawley dams with high fructose (60%) diet or normal chow. Each litter was treated with either saline or lipopolysaccharide (LPS) on postnatal day (P)3 and P5 and two pups were tested for USVs after maternal separation on P7...
February 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29428598/investigating-the-influence-of-polyplex-size-on-toxicity-properties-of-polyethylenimine-mediated-gene-delivery
#15
Reza Kazemi Oskuee, Maryam Dabbaghi, Leila Gholami, Sajedeh Taheri-Bojd, Mahdi Balali-Mood, Seyyed Hadi Mousavi, Bizhan Malaekeh-Nikouei
AIMS: Gene therapy is a promising strategy for the treatment of various diseases. Polyethylenimine (PEI) has received considerable attention for gene delivery applications due to their appropriate properties. However, their toxicity has raised concerns which cause to be used with cautious. This study aimed to prepare different complexes of PEI/DNA and evaluate their parameters affecting in vitro cytotoxicity. Also, apoptosis rate was measured to determine the mechanism of cell toxicity...
February 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29427649/rat-strain-differences-in-peritoneal-immune-cell-response-to-selected-gut-microbiota-a-crossroad-between-tolerance-and-autoimmunity
#16
Veljko Blagojević, Vesna Kovačević-Jovanović, Ivana Ćuruvija, Raisa Petrović, Ivana Vujnović, Vesna Vujić, Stanislava Stanojević
AIMS: Some gut commensals can be protective, whereas others are implicated as necessary for development of inflammatory/autoimmune diseases. Peritoneal immune cells may play an important role in promoting autoimmunity in response to gut microbiota. This study investigated the phenotype and the function of peritoneal immune cells in the autoimmunity-resistant Albino Oxford (AO), and the autoimmunity-prone Dark Agouti (DA) rat strains upon stimulation with their own colonic E. coli or Enterococcus...
February 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/29425766/antidiabetic-effects-of-sglt2-inhibitor-ipragliflozin-in-type-2-diabetic-mice-fed-diets-containing-different-carbohydrate-contents
#17
Atsuo Tahara, Toshiyuki Takasu
AIMS: Daily intake of carbohydrates differs among individual patients with type 2 diabetes. Here, we investigated whether or not dietary carbohydrate content affects the efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin in type 2 diabetic mice. MAIN METHODS: Diabetic mice were fed a regular (50% kcal), high (75% kcal)-, or low (25% kcal)-carbohydrate diet. Ipragliflozin was orally administered once a day for 4 weeks. KEY FINDINGS: In all groups, mice exhibited characteristics of type 2 diabetes, including hyperglycemia, hyperinsulinemia, and obesity...
February 6, 2018: Life Sciences
https://www.readbyqxmd.com/read/29421440/evaluation-of-interferon-gamma-release-assays-in-extrasanguinous-body-fluids-for-diagnosing-tuberculosis-a-systematic-review-and-meta-analysis
#18
An Wen, Xin-Hui Qu, Kun-Nan Zhang, Er-Ling Leng, Yue Ren, Xiao-Mu Wu
AIMS: In this study, we conducted a meta-analysis to systematically compare the diagnostic accuracy of IGRAs performed for extrasanguinous body fluids with that performed for blood in the diagnosis of TB. MAIN METHODS: Multiple English and Chinese databases were searched up to November 2017. Studies that complied with the guidelines for the Quality Assessment of Diagnostic Accuracy Studies and used QuantiFERON-TB Gold In-Tube and/or T-SPOT.TB (ELISPOT) assays on both blood and extrasanguinous body fluids were included...
February 5, 2018: Life Sciences
https://www.readbyqxmd.com/read/29421439/lncrna-fal1-promotes-cell-proliferation-and-migration-by-acting-as-a-cerna-of-mir-1236-in-hepatocellular-carcinoma-cells
#19
Baoguo Li, Rui Mao, Changfu Liu, Weihao Zhang, Yong Tang, Zhi Guo
BACKGROUND: Long non-coding RNAs (LncRNAs) have been demonstrated to play crucial role in tumor growth and metastasis for hepatocellular carcinoma (HCC). LncRNA FAL1 has been indicated to promote the progression of various cancers. However, the role of lncRNA FAL1 in HCC was poorly understood. METHODS: The expression levels of lncRNA FAL1 in HCC tissues and cells were determined by RT-qPCR. The roles of lncRNA FAL1 on HCC cells were investigated by MTT, colony formation, transwell, RT-qPCR, and Western blotting...
February 5, 2018: Life Sciences
https://www.readbyqxmd.com/read/29421438/in-vitro-study-of-fuz-as-a-novel-potential-therapeutic-target-in-non-small-cell-lung-cancer
#20
Minwei He, Kangqi Li, Chuanfei Yu, Bingfeng Lv, Ning Zhao, Jinhai Deng, Lulu Cao, He Huang, Ang Yin, Taiping Shi, Lu Wang
FUZ is regarded as a planar cell polarity effector that controls multiple cellular processes during vertebrate development. However, the role of FUZ in tumor biology remains poorly studied. Our purpose of this study is to discover the physiological effects and mechanism of FUZ in non-small-cell lung cancer (NSCLC) in vitro. With the help of bioinformatics analysis, we noticed that the expression level of FUZ negatively correlates with prognosis of NSCLC patients. Exogenous FUZ expression markedly promoted cell proliferation of NSCLC cells...
February 5, 2018: Life Sciences
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