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https://www.readbyqxmd.com/read/29689275/occupational-exposure-to-pesticides-in-family-agriculture-and-the-oxidative-biochemical-and-hematological-profile-in-this-agricultural-model
#1
Márcia Denise Pavanelo Cattelan, Patrícia Maurer, Fernandez Garcia, Lyana Feijoó Berro, Michel Mansur Machado, Vanusa Manfredini, Jacqueline da Costa Escobar Piccoli
No abstract text is available yet for this article.
April 21, 2018: Life Sciences
https://www.readbyqxmd.com/read/29689274/the-mechanistic-effects-of-the-dioxonaphthoimidazolium-analog-ym155-in-renal-cell-carcinoma-cell-cycling-and-apoptosis
#2
Mei Yi Sim, Mei Lin Go, John Shyi Peng Yuen
AIM: To investigate the effect of dioxonaphthoimidazolium analog YM155 on cell cycle progression of the clear-cell variant of renal cell carcinoma (ccRCC). MAIN METHODS: Cell cycle analysis was performed using bromodeoxyuridine (BrdU) and PI, apoptosis initiation was monitored using Annexin V and proteins expression was determined using western immunoblotting. KEY FINDINGS: Here, we showed that YM155 activated stress-related molecules (histone H2AX, checkpoint kinases Chk1 and Chk2, p53) that mediate DNA damage checkpoint responses...
April 21, 2018: Life Sciences
https://www.readbyqxmd.com/read/29689273/melatonin-inhibits-osteosarcoma-stem-cells-by-suppressing-sox9-mediated-signaling
#3
Hao Qu, Yue Xue, Wenwen Lian, Cong Wang, Jia He, Qihong Fu, Lijia Zhong, Nong Lin, Lihua Lai, Zhaoming Ye, Qingqing Wang
AIMS: Melatonin (N-acetyl-5-methoxytryptamine) has been reported to suppress epithelial-mesenchymal transition and cancer stem cells in some types of cancer. However, the effects of melatonin on the osteosarcoma stem cells, epithelial-mesenchymal transition and metastasis of osteosarcoma are still not clear. The present study was conducted to dissect the activity of melatonin on the osteosarcoma stem cells and the underlying mechanisms. MAIN METHODS: MTT, wound healing, transwell assay and western blotting were conducted to determine the effect of melatonin on osteosarcoma cell invasion and migration and downregulation of SOX9-mediated signaling...
April 21, 2018: Life Sciences
https://www.readbyqxmd.com/read/29689272/ontogeny-and-aging-of-nrf2-pathway-genes-in-livers-of-rats
#4
Shang-Fu Xu, Li-Li Ji, Qin Wu, Jin Li, Jie Liu
The Nrf2/Keap1 antioxidant system plays important roles in protecting against oxidative stress and toxic stimuli, which may vary in infants, elderly, and females. AIM: The constitutive expression of the Nrf2 genes during development and aging in both sexes would help our understanding of the Nrf2/Keap1 pathway in toxicological studies. MAIN METHODS: Sprague Dawley rat livers were collected at 11 age points from prenatal (-2d), neonatal (1, 7, 14 and 21d), at puberty (28 and 35d), at adulthood (60 and 180d), to aging (540 and 800d) from both sexes...
April 21, 2018: Life Sciences
https://www.readbyqxmd.com/read/29684447/type-3-iodothyronine-deiodinase-is-expressed-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#5
Kumiko Nishimura, Masafumi Takeda, Jun K Yamashita, Ichiro Shiojima, Nagaoki Toyoda
AIMS: Type 3 iodothyronine deiodinase (D3), which converts thyroxine (T4 ) and 3,5,3'-triiodothyronine (T3 ) to 3,3',5'-triiodothyronine (rT3 ) and 3,3'-diiodothyronine (T2 ), respectively, inactivates thyroid hormones. We investigated the expression and regulation of D3 in human cardiomyocytes which were differentiated from human induced pluripotent stem cells (hiPSCs). MAIN METHODS: We characterized D3 activity using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29684446/angiotensin-receptor-blocker-losartan-ameliorates-neuroinflammation-and-behavioral-consequences-of-lipopolysaccharide-injection
#6
Hossein Salmani, Mahmoud Hosseini, Farimah Beheshti, Yousef Baghcheghi, Hamid Reza Sadeghnia, Mohammad Soukhtanloo, Mohammad Naser Shafei, Majid Khazaei
AIMS: Neuroinflammation has a critical role in brain diseases. Angiotensin II (Ang II) is an important player in inflammation via stimulating of Ang II type 1 receptor (AT1R). In this study, the effects of losartan, an Ang II receptor blocker, on the brain inflammation, oxidative stress and behavioral consequences of lipopolysaccharide (LPS) injection were investigated. MAIN METHODS: Rats were intraperitoneally (i.p.) injected with 1 or 3 mg/kg losartan or saline for 24 continuous days...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29684445/modelling-human-prostate-cancer-rat-models
#7
REVIEW
Elisabete Nascimento-Gonçalves, Ana I Faustino-Rocha, Fernanda Seixas, Mário Ginja, Bruno Colaço, Rita Ferreira, Margarida Fardilha, Paula A Oliveira
Prostate cancer is the second most common cancer in men, affecting approximately 1.1 million men worldwide. In this way, the study of prostate cancer biopathology and the study of new potential therapies is of paramount importance. Several rat models were developed over the years to study prostate cancer, namely spontaneous models, chemically-induced models, implantation of cancer cell lines and genetically-engineered models. This manuscript aimed to provide the readers with an overview of the rat models of prostate cancer, highlighting their advantages and disadvantages, as well as, their applications...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29684444/studies-into-slo1-k-channels-and-their-ligand-docosahexaenoic-acid-in-murine-sepsis-to-delineate-off-target-effects-of-immunonutrition
#8
Bianka Wissuwa, Stefan H Heinemann, Michael Bauer, Sina M Coldewey
AIMS: Studies on omega-3 fatty acids, including docosahexaenoic acid (DHA), reveal diverging results: Their intake is recommended in cardiovascular disease and major surgery, while evidence argues against use in septic patients. DHA mediates its blood-pressure-lowering effect through Slo1 channels that are expressed on cardiovascular and immune cells. We hypothesised that conflicting effects of immunonutrition could be explained by the influence of omega-3 fatty acids on systemic blood pressure or immune effector cells through Slo1...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29684443/modified-porcine-surfactant-enriched-by-recombinant-human-superoxide-dismutase-for-experimental-meconium-aspiration-syndrome
#9
Jana Kopincova, Pavol Mikolka, Maros Kolomaznik, Petra Kosutova, Andrea Calkovska, Daniela Mokra
AIMS: Combination of exogenous surfactant with antioxidant enzyme recombinant human superoxide dismutase (rhSOD) was tested in the treatment of experimental meconium aspiration syndrome as oxidative processes play key role in its pathogenesis. MATERIAL AND METHODS: Young New Zealand rabbits were instilled by saline (Sal group) or by meconium suspension (Mec group). Some of meconium-instilled animals were treated by surfactant alone (Surf group) or surfactant in combination with rhSOD (Surf + SOD group) and oxygen-ventilated for 5 h...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29679702/alamandine-attenuates-sepsis-associated-cardiac-dysfunction-via-inhibiting-mapks-signaling-pathways
#10
Peng Li, Xi-Ru Chen, Fei Xu, Chi Liu, Chang Li, Hui Liu, Hui Wang, Wei Sun, Yan-Hui Sheng, Xiang-Qing Kong
Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Alamandine is an important biologically active peptide in the renin-angiotensin system. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the signaling pathways involved in these events. Experiments were carried out in mice treated with lipopolysaccharide (LPS) or alamandine, and in neonatal rat cardiomyocytes. Alamandine increased the ejection fraction and fractional shortening, both of which were decreased upon LPS infusion in mice...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29679701/the-role-of-%C3%AE-2-integrin-associated-heparin-binding-protein-release-in-ards
#11
Yang Liu, Shaolin Ma, Xuebin Wang, Yajing Feng, Shouqin Zhang, Sheng Wang, Xiangyu Zhang
AIMS: PMNs (polymorphonuclear neutrophil) play important roles in early stage of inflammation induced ARDS (Acute Respiratory Distress Syndrome). Both HBP (Heparin-Binding Protein) released from active PMNs and β2 integrins on the surface of PMNs are involved in vascular leakage. The role and relationship of HBP and β2 integrins on ARDS still requires study. MATERIALS AND METHODS: We established ARDS model using C57BL/6 mice with cecal ligation and puncture and eliminating HBP and β2 integrin with respective antibodies...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29679700/toxicity-of-porcelain-fused-to-metal-substrate-to-zebrafish-danio-rerio-embryos-and-larvae
#12
Libo Zhao, Jing Si, Yuan Wei, Sirui Li, Yanjiao Jiang, Rong Zhou, Bin Liu, Hong Zhang
AIMS: Porcelain-fused-to-metal (PFM) crowns are a standard restoration technique in dentistry, but toxicity of PFM in vivo has not been systematically evaluated. The present study evaluated the effects of various metal alloy shells of PFM crowns on the development of zebrafish embryos and larvae in order to determine the safety of these materials. MAIN METHODS: Gold palladium (Au-Pd), silver palladium (Ag-Pd), Nickel chromium (Ni-Cr), cobalt chromium (Co-Cr), titanium (Ti) alloy porcelain crowns were immersed in artificial saliva for 1, 4, and 7 weeks, and the leach solution was collected and used to treat zebrafish embryos at 4-144 h PFM...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29679699/amaryllidaceae-alkaloids-as-agents-with-protective-effects-against-oxidative-neural-cell-injury
#13
Natalie Cortes, Carol Castañeda, Edison H Osorio, Gloria Patricia Cardona-Gomez, Edison Osorio
AIMS: Determine a relationship between the neuroprotective activity and the antioxidant capacity of the Amaryllidaceae alkaloids in a model of Glu excitotoxicity in rat cortical neurons. MATERIALS AND METHODS: Was evaluated several alkaloidal fractions isolated from Amaryllidaceae species, a family known to contain neuroprotective alkaloids, in a model of Glu excitotoxicity in rat cortical neurons. In addition, several mechanisms of antioxidant activity were used, and a theoretical study of the antioxidants was performed...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29678745/neurobehavioral-and-biochemical-modulation-following-administration-of-mgo-and-zno-nanoparticles-in-the-presence-and-absence-of-acute-stress
#14
Mozhgan Torabi, Mahnaz Kesmati, Nahid Pourreza, Hossein Najafzadeh Varzi, Hamid Galehdari
In this work, the effects of MgO and ZnO nanoparticles were investigated on some behavioral, hormonal and biochemical changes following acute stress. Wistar male rats were divided into groups of control, different times of restraint stress (90, 180 and 360 min), nano-MgO or nano-ZnO alone and with acute restraint stress. Anxiety-like behaviors and pain perception were evaluated by elevated plus maze and hot plate apparatus respectively. Levels of corticosterone hormone, malondialdehyde (MDA) and catalase activity, Mg, Zn, Fe and Ca were evaluated in the serum and hippocampus...
April 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29678744/long-noncoding-rna-lncarsr-promotes-hepatic-cholesterol-biosynthesis-via-modulating-akt-srebp-2-hmgcr-pathway
#15
Jiabin Hang, Shangjun Chen, Dongliang Cai, Deqiang Bian, Fengling Wang
AIMS: Disruption of cholesterol homeostasis has been identified as a major factor in the pathogenesis of atherosclerosis, myocardial infarction, and strokes. Long noncoding RNAs (lncRNAs) have emerged as critical players in cellular cholesterol metabolism, but their functions are still largely unknown. MATERIALS AND METHODS: C57BL6/j mice were fed with high cholesterol diet (containing 4% cholesterol) or chow diet. Adenoviruses-lncARSR and lncARSR shRNA were used to overexpress or knockdown lncARSR expression...
April 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29678743/the-orphan-nuclear-receptor-nr4a1-attenuates-oxidative-stress-induced-%C3%AE-cells-apoptosis-via-up-regulation-of-glutathione-peroxidase-1
#16
Yingfeng Yang, Fangyu Xie, Dandan Qin, Chen Zong, Feng Han, Zeqing Pu, Dong Liu, Xia Li, Yuchao Zhang, Yuantao Liu, Xiangdong Wang
AIMS: Our previous study showed that NR4A1 protects against oxidative stress-induced cell apoptosis. However, the targets downstream of NR4A1 are incompletely known. Glutathione peroxidase 1 (GPX1) is the most common antioxidant enzyme in the glutathione peroxidase class. In this study, we aimed to investigate whether GPX1 is a mediator of the protective effects of NR4A1 in pancreatic β cells. MAIN METHODS: A pancreatic β cell line, MIN6, was used to generate NR4A1 over-expression cell line...
April 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29678742/a-six-gene-based-prognostic-signature-for-hepatocellular-carcinoma-overall-survival-prediction
#17
Zhenglu Wang, Dahong Teng, Yan Li, Zhandong Hu, Lei Liu, Hong Zheng
AIMS: The purpose of this study was to propose a pipeline to identify prognostic signature for HCC overall survival (OS) prediction based on HCC gene expression datasets from The Cancer Genome Atlas (TCGA). RESULTS: Differential expression analysis identified 3573 genes aberrantly expressed (DEGs) in HCC samples. Univariate cox regression analysis obtained 1605 and 1067 HCC OS and relapse free survival (RFS) related genes, which are abbreviated as OS-Gene and RFS-Gene respectively...
April 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29674122/4-fluorobenzaldehyde-limonene-based-thiosemicarbazone-induces-apoptosis-in-pc-3-human-prostate-cancer-cells
#18
Bruna Dos Santos Rodrigues, Renato Ivan de Ávila, Polyana Lopes Benfica, Ludmila Pires Bringel, Cecília Maria Alves de Oliveira, Fábio Vandresen, Cleuza Conceição da Silva, Marize Campos Valadares
AIMS: This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells. MAIN METHODS: Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT assay. Morphology examination of PC-3 cells treated with 4-FTSC was also performed as well as the cell death mechanisms induced were investigated using flow cytometry...
April 16, 2018: Life Sciences
https://www.readbyqxmd.com/read/29665355/combination-therapy-with-polydeoxyribonucleotide-and-proton-pump-inhibitor-enhances-therapeutic-effectiveness-for-gastric-ulcer-in-rats
#19
Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Eun-Sang Ji, Chang-Ju Kim, Jin-Hee Han, In Taik Hong, Min Seop Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeon
AIMS: The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regeneration is added, the effectiveness of GU treatment can be enhanced. Thus, in order to improve the therapeutic effect on GU, we tried to develop combination therapy promoting regeneration in injured tissue besides suppressing gastric acid secretion. MAIN METHODS: Polydeoxyribonucleotide (PDRN) was selected to evaluate tissue regeneration, and pantoprazole was chosen as one of the PPIs...
April 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29660434/the-beclomethasone-anti-inflammatory-effect-occurs-in-cell-mediator-dependent-manner-and-is-additively-enhanced-by-formoterol-nfkb-p38-pka-analysis
#20
Silvana Cianchetti, Cristina Cardini, Alessandro Corti, Marta Menegazzi, Elena Darra, Eleonora Ingrassia, Alfonso Pompella, Pierluigi Paggiaro
AIMS: Beclomethasone/formoterol (BDP/FOR) has been reported to be more effective than its separate components in airway disease control and in airway inflammation improvement. However, BDP/FOR effects on cytokine-induced inflammation in structural cells have not been described and whether these effects occur in a cell- and mediator-dependent manner has not been fully elucidated. We sought to evaluate BDP and/or FOR effects on endothelial ICAM-1, E-selectin, IL-8 and on bronchial epithelial ICAM-1 and IL-8...
April 13, 2018: Life Sciences
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