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Journal of Neurophysiology

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https://www.readbyqxmd.com/read/28515289/learning-temporal-context-shapes-the-prestimulus-alpha-oscillations-and-improves-the-visual-discrimination-performance
#1
Tahereh Toosi, Ehsan K Tousi, Hossein Esteky
Time is an inseparable component of every physical event that we perceive, yet it is not clear how the brain processes time or how the neuronal representation of time affects our perception of events. Here, we asked subjects to perform a visual discrimination task, while we changed the temporal context in which the stimuli were presented. We collected electroencephalography (EEG) signals in two temporal contexts. Predictable blocks: stimuli were presented after a constant delay relative to a visual cue, and unpredictable blocks: stimuli were presented after variable delays relative to the visual cue...
May 17, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28515288/motor-recovery-beginning-23-years-after-ischemic-stroke
#2
Peter Sörös, Robert Teasell, Daniel F Hanley, J David Spence
It is widely believed that most stroke recovery occurs within 6 months, with little benefit of physiotherapy or other modalities beyond a year. We report a remarkable case of stroke recovery beginning 23 years after a severe stroke due to embolization from the innominate artery and subclavian artery, resulting from compression of the right subclavian artery by a cervical rib. The patient had a large right fronto-parietal infarction with severe left hemiparesis, and a totally non-functional spastic left hand...
May 17, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28515287/context-effects-on-smooth-pursuit-and-manual-interception-of-a-disappearing-target
#3
Philipp Kreyenmeier, Jolande Fooken, Miriam Spering
In our natural environment, we interact with moving objects that are surrounded by richly textured, dynamic visual contexts. Yet, most laboratory studies on vision and movement show visual objects in front of uniform grey backgrounds. Context effects on eye movements have been widely studied, but it is less well known how visual contexts affect hand movements. Here we ask whether eye and hand movements integrate motion signals from target and context similarly or differently, and whether context effects on eye and hand change over time...
May 17, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28515286/responses-of-purkinje-cells-in-the-oculomotor-vermis-of-monkeys-during-smooth-pursuit-eye-movements-and-saccades-comparison-with-floccular-complex
#4
Ramanujan T Raghavan, Stephen G Lisberger
We recorded the responses of Purkinje cells in the oculomotor vermis during smooth pursuit and saccadic eye movements. Our goal was to characterize the responses in the vermis using approaches that would allow direct comparisons with responses of Purkinje cells in another cerebellar area for pursuit, the floccular complex. Simple-spike firing of vermis Purkinje cells is direction selective during both pursuit and saccades, but the preferred directions are sufficiently independent so that downstream circuits could decode signals to drive pursuit and saccades separately...
May 17, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28515285/cortical-amplification-models-of-the-experience-dependent-development-of-selective-columns-and-response-sparsification
#5
Ian Kaplan Christie, Paul Miller, Stephen D Van Hooser
The development of direction-selective cortical columns requires visual experience, but the neural circuits and plasticity mechanisms that are responsible for this developmental transition are unknown. To gain insight into the mechanisms that could underlie experience-dependent increases in selectivity, we explored families of cortical amplifier models that enhance weakly biased feed-forward signals. Here, we focused exclusively on possible contributions of cortico-cortical connections and took feed-forward input to be constant...
May 17, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28515284/long-lasting-increase-in-axonal-excitability-following-epidurally-applied-dc
#6
Elzbieta Jankowska, Dominik Kaczmarek, Francesco Bolzoni, Ingela Hammar
Effects of direct current (DC) on nerve fibres have primarily been investigated during or just after DC application. However, locally applied cathodal DC was recently demonstrated to increase the excitability of intraspinal preterminal axonal branches for more than one hour. The aim of this study was, therefore, to investigate whether DC evokes a similarly long-lasting increase in the excitability of myelinated axons within the dorsal columns. The excitability of dorsal column fibres stimulated epidurally was monitored by recording compound action potentials in peripheral nerves in acute experiments in deeply anaesthetized rats...
May 17, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28515283/anisomorphic-cortical-reorganization-in-asymmetric-sensorineural-hearing-loss
#7
Steven W Cheung, Craig Anthony Atencio, Eliott R J Levy, Robert C Froemke, Christoph E Schreiner
Acoustic trauma or inner ear disease may predominantly injure one ear, causing asymmetric sensorineural hearing loss (SNHL). While characteristic frequency (CF) map plasticity of primary auditory cortex (AI) contralateral to the injured ear has been detailed, there is no study that also evaluates ipsilateral AI to compare cortical reorganization across both hemispheres. We assess whether normal isomorphic mirror image relationship between the two hemispheres is maintained or disrupted in mild-to-moderate asymmetric SNHL of adult squirrel monkeys...
May 17, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490646/a-missense-mutation-in-grm6-reduces-but-does-not-eliminate-mglur6-expression-or-rod-depolarizing-bipolar-cell-function
#8
Neal S Peachey, Nazarul Hasan, Bernard FitzMaurice, Samantha Burrill, Gobinda Pangeni, Son Yong Karst, Laura Reinholdt, Melissa L Berry, Marge Strobel, Ronald George Gregg, Maureen A McCall, Bo Chang
GRM6 encodes the metabotropic glutamate receptor 6 (mGluR6) used by retinal depolarizing bipolar cells (DBCs). Mutations in GRM6 lead to DBC dysfunction, and underlie the human condition autosomal recessive complete congenital stationary night blindness. Mouse mutants for Grm6 are important models for this condition. Here we report a new Grm6 mutant, identified in an electroretinogram (ERG) screen of mice maintained at The Jackson Laboratory. The Grm6(nob8) mouse has a reduced amplitude b-wave component of the ERG, which reflects light-evoked DBC activity...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490645/evidence-of-adaptations-of-locomotor-neural-drive-in-response-to-enhanced-intermuscular-connectivity-between-the-triceps-surae-muscles-of-the-rat
#9
Michel Bernabei, Jaap H van Dieën, Huub Maas
The aims of this study were to investigate changes (i) in the coordination of activation of the triceps surae muscle group and (ii) in muscle belly length of soleus (SO) and lateral gastrocnemius (LG) during locomotion (trotting) in response to increased stiffness of intermuscular connective tissues in the rat. We measured muscle activation and muscle belly lengths, as well as hindlimb kinematics, before and after an artificial enhancement of the connectivity between SO and LG muscles obtained by implanting a tissue-integrating surgical mesh at the muscles' interface...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490644/background-noise-exerts-diverse-effects-on-the-cortical-encoding-of-foreground-sounds
#10
Brian James Malone, Marc A Heiser, Ralph Eugene Beitel, Christoph E Schreiner
In natural listening conditions, many sounds must be detected and identified in the context of competing sound sources which function as background noise. Traditionally, noise is thought to degrade the cortical representation of sounds by suppressing responses and increasing response variability. However, recent studies of neural network models and brain slices have shown that background synaptic noise can improve the detection of signals. Because acoustic noise affects the synaptic background activity of cortical networks, it may improve the cortical responses to signals...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490643/predicting-the-response-of-striatal-spiny-neurons-to-sinusoidal-input
#11
Charles J Wilson
Spike timing effects of small amplitude sinusoidal currents were measured in mouse striatal spiny neurons firing repetitively. Spike timing reliability varied with the stimulus frequency. For frequencies near the cell's firing rate, the cells altered firing rate to match the stimulus and became phase-locked to it. The stimulus phase of firing during lock depended on the stimulus frequency relative to the cell's unperturbed firing rate. Interspike intervals during sinusoidal stimulation were predicted using an iterative map constructed from the cells' phase resetting curve...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490642/split-arm-swinging-the-effect-of-arm-swinging-manipulation-on-inter-limb-coordination-during-walking
#12
Moshe Bondi, Gabi Zeilig, Ayala Bloch, Alfonso Fasano, Meir Plotnik
Human locomotion is defined by bilateral coordination of gait (BCG) and shared features with the fore-hind limb coordination of quadrupeds. The objective of the present study is to explore the influence of arm swinging (AS) on BCG. Sixteen young healthy individuals (eight females; eight right motor-dominant, eight left-motor dominant) participated. Participants performed 10 walking trials (2 min). In each of the trials AS was unilaterally manipulated (e.g., arm restriction, weight on the wrist) bilaterally manipulated, or not manipulated...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490641/fetal-alcohol-exposure-reduces-responsiveness-of-taste-nerves-and-trigeminal-chemosensory-neurons-to-ethanol-and-its-flavor-components
#13
John I Glendinning, Joyce Tang, Ana Paula Morales Allende, Bruce P Bryant, Lisa Youngentob, Steven L Youngentob
Fetal alcohol exposure (FAE) leads to increased intake of ethanol in adolescent rats and humans. We asked whether these behavioral changes may be mediated in part by changes in responsiveness of the peripheral taste and oral trigeminal systems. We exposed the experimental rats to ethanol in utero by administering ethanol to dams through a liquid diet; we exposed the control rats to an isocaloric and isonutritive liquid diet. To assess taste responsiveness, we recorded responses of the chorda tympani (CT) and glossopharyngeal (GL) nerves to lingual stimulation with ethanol, quinine, sucrose and NaCl...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490640/transcribing-the-connectome-roles-for-transcription-factors-and-chromatin-regulators-in-activity-dependent-synapse-development
#14
Liang-Fu Chen, Allen S Zhou, Anne E West
The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that allow nuclear transcription factors and chromatin regulatory proteins to encode aspects of specificity in experience-dependent synapse development. Here we review the evidence for the transcriptional mechanisms that sculpt activity-dependent aspects of synaptic connectivity during postnatal development and we discuss how disruption of these processes is associated with aberrant brain development in autism and intellectual disability...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28469003/regulation-of-axonal-regeneration-following-spinal-cord-injury-in-the-lamrpey
#15
Jessica A Benes, Kylie N House, Frank N Burks, Kris P Conaway, Donald P Julien, Jeffrey P Donley, Michael A Iyamu, Andrew D McClellan
Following rostral spinal cord injury (SCI) in larval lampreys, injured descending brain neurons, particularly reticulospinal (RS) neurons, regenerate their axons, and locomotor behavior recovers in a few weeks. However, axonal regeneration of descending brain neurons is mostly limited to relatively short distances, but the mechanisms for incomplete axonal regeneration are unclear. First, lampreys with rostral SCI exhibited greater axonal regeneration of descending brain neurons, including RS neurons, as well as more rapid recovery of locomotor muscle activity right below the lesion site compared to animals with caudal SCI...
May 3, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28469002/neuropeptide-y-alters-vta-dopamine-neuron-activity-through-both-pre-and-post-synaptic-mechanisms
#16
Katherine Stuhrman West, Aaron G Roseberry
The mesocorticolimbic dopamine system, the brain's reward system, regulates many different behaviors including food intake, food reward, and feeding related behaviors, and there is increasing evidence that hypothalamic feeding-related neuropeptides alter dopamine neuron activity to affect feeding. For example, neuropeptide-Y (NPY), a strong orexigenic hypothalamic neuropeptide, increases motivation for food when injected into the ventral tegmental area (VTA). How NPY affects the activity of VTA dopamine neurons to regulate feeding behavior is unknown, however...
May 3, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28469001/cerebellar-patients-do-not-benefit-from-cerebellar-or-m1-transcranial-direct-current-stimulation-during-force-field-reaching-adaptation
#17
Thomas Hulst, Liane John, Michael Küper, Jos N van der Geest, Sophia L Göricke, Opher Donchin, Dagmar Timmann
Several studies have identified transcranial direct current stimulation (tDCS) as a potential tool in the rehabilitation of cerebellar disease. Here, we tested whether tDCS could alleviate motor impairments of subjects with cerebellar degeneration. Three groups took part in this study: twenty individuals with cerebellar degeneration, twenty age-matched controls and thirty young controls. A standard reaching task with force field-perturbations was used to compare motor adaptation between groups and to measure the effect of stimulation of the cerebellum or primary motor cortex (M1)...
May 3, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28469000/circuit-feedback-increases-activity-level-of-a-circuit-input-through-interactions-with-intrinsic-properties
#18
Dawn M Blitz
Central pattern generator (CPG) motor circuits underlying rhythmic behaviors provide feedback to the projection neuron inputs that drive these circuits. This feedback elicits projection neuron bursting linked to CPG rhythms. The brief periodic interruptions in projection neuron activity in turn influence CPG output, gate sensory input, and enable coordination of multiple target CPGs. However, despite the importance of projection neuron activity level for circuit output, it remains unknown whether feedback also regulates projection neuron intraburst firing rates...
May 3, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28468999/ketamine-induced-converged-synchronous-gamma-oscillations-in-the-cortico-basal-ganglia-network-of-non-human-primates
#19
Maya Slovik, Boris Rosin, Shay Moshel, Rea Mitelman, Eitan Schechtman, Renana Eitan, Aeyal Raz, Hagai Bergman
NMDA (N-methyl-D-aspartate) antagonists are widely used in anesthesia, pain management, schizophrenia animal model studies and recently as potential antidepressants. However the mechanisms underlying their anesthetic, psychotic, cognitive and emotional effects are still elusive. The basal-ganglia (BG) integrate input from different cortical domains through its dopamine modulated connections, to achieve optimal behavior control. NMDA antagonists have been shown to induce gamma oscillations in human EEG recordings and in rodents cortical and BG networks...
May 3, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28468998/rapid-accumulation-of-inhibition-accounts-for-saccades-curved-away-from-distractors
#20
Devin Heinze Kehoe, Mazyar Fallah
Saccades curved towards a distractor are accompanied by a burst of neuronal activation at the distractor locus in the intermediate layers of the superior colliculus (SCi) ~30 ms prior to the initiation of a saccade (McPeek et al., 2003; Port and Wurtz, 2003). Although saccades curve away from inactivated SCi loci (Aizawa and Wurtz, 1998), whether inhibition is restricted to a similar critical epoch for saccades curved away from a distractor remains unclear (White et al., 2012). We examined this possibility by modeling human saccade curvature as a function of the time between onset of a task irrelevant luminance- or color-modulated distractor and initiation of an impending saccade, referred to as saccade distractor onset asynchrony (SDOA)...
May 3, 2017: Journal of Neurophysiology
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