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Journal of the Neurological Sciences

João Passos, Hipólito Nzwalo, Mariana Valente, Joana Marques, Ana Azevedo, Eduardo Netto, António Mota, Alexandra Borges, Sofia Nunes, Duarte Salgado
BACKGROUND: With the expected growth and aging of the population of primary central nervous system tumours (PCNST) survivors, attention to the radiation-induced late brain injury is fundamental. Late focal hemosiderin deposition (FHD) lesions, namely microbleeds and cavernomas, are among the presumable late cerebrovascular complications associated with radiotherapy for PCNST. OBJECTIVE: To explore association between PCNST radiotherapy and the occurrence FHD lesions and to address the correlation between the topographic location of these microvascular lesions with the focal radiotherapy location...
November 11, 2016: Journal of the Neurological Sciences
Nobuaki Yamamoto, Junichiro Satomi, Yuki Yamamoto, Yuishin Izumi, Shinji Nagahiro, Ryuji Kaji
BACKGROUND AND PURPOSE: Conventional digital subtraction angiography (DSA) has been a useful tool for the diagnosis of cranial dural arteriovenous fistula (cDAVF). In most patients with cDAVF, blood flow through the arteriovenous shunt was pooled at diseased veins and/or sinuses. Therefore, we speculated that pooled blood at diseased veins in patients with cDAVF could be detected on arterial spin-labeled imaging (ASL). The purpose of the present study was to investigate the usefulness of ASL to detect cDAVF...
November 10, 2016: Journal of the Neurological Sciences
Somsak Tiamkao, Sineenard Pranboon, Kaewjai Thepsuthammarat, Kittisak Sawanyawisuth
There are limited data in terms of incidence, clinical features, and outcomes in elderly patients with status epilepticus (SE) in national level. We retrospectively explored national data in Thailand for reimbursement of all SE in elderly patients admitted in the fiscal year 2004-2012. SE in elderly patients (age>60years old) were diagnosed and searched based on ICD 10 (G41) from the national database of from the National Health and Security Office. There were 3326 SE in elderly patients. The national incidence of SE was highest at 8...
November 9, 2016: Journal of the Neurological Sciences
Xiao-Er Wei, Jia Zhou, Wen-Bin Li, Yu-Wu Zhao, Ming-Hua Li, Yue-Hua Li
To investigate the feasibility of DWI-FLAIR mismatch in identifying patients who might benefit from thrombolytic therapy within 4.5-6h, we analyzed the data of 105 ischemic stroke patients with known time of symptom onset who underwent MRI within 6h of stroke and thrombolysis between December 2006 and December 2013. They were divided into three groups: symptom onset within 4.5h (n=66); 4.5-6h and FLAIR images negative (n=9); and 4.5-6h and FLAIR images positive (n=30). Outcome of thrombolysis was assessed for each group by recanalization rate, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores...
November 9, 2016: Journal of the Neurological Sciences
Roberto Tiribuzi, Lucia Crispoltoni, Valerio Chiurchiù, Antonella Casella, Celeste Montecchiani, Alberto Marco Del Pino, Mauro Maccarrone, Carlo Alberto Palmerini, Carlo Caltagirone, Toshitaka Kawarai, Aldo Orlacchio, Antonio Orlacchio
Herbal medicines have been recently employed in research and clinical studies for the potential treatment of behavioral and psychological symptoms associated with Alzheimer's Disease (AD) and other types of dementia. The present study investigates the effect of trans-crocetin, an active constituent of Crocus sativus L., to restore in vitro the reduced ability of AD patients' monocytes to degrade amyloid-β(1-42) (Aβ42). CD14(+) monocytes from 22 sporadic AD patients with moderate cognitive impairment were isolated; then, the role of trans-crocetin, purified from saffron extracts, was evaluated in terms of Aβ42 degradation rate through flow cytometry, as well as expression of cathepsin B by Western blotting...
November 6, 2016: Journal of the Neurological Sciences
Rimas V Lukas, Angela D Blood, James R Brorson, Dara V F Albert
Much of the care provided by practicing neurologists takes place in outpatient clinics. However, neurology trainees often have limited exposure to this setting. Adequate incorporation of outpatient care in neurology training is vital; however it is often hampered by numerous challenges. We detail a number of these challenges and suggest potential means for improvement.
November 5, 2016: Journal of the Neurological Sciences
Takuya Kanamaru, Satoshi Suda, Kanako Muraga, Seiji Okubo, Yoko Watanabe, Syuichi Tsuruoka, Kazumi Kimura
BACKGROUND: Reduced glomerular filtration rate (GFR) and albuminuria have been independently associated with an increased risk of stroke and unfavorable long-term outcomes. However, the association between GFR, albuminuria, and early neurological deterioration (END) in patients with ischemic stroke has not been well studied to date. We therefore investigated the ability of estimated GFR (eGFR) and albuminuria to predict END in patients with acute ischemic stroke. METHODS: We retrospectively enrolled 294 patients that were admitted to our stroke center with acute ischemic stroke between January 2011 and September 2012...
November 5, 2016: Journal of the Neurological Sciences
Lucy Cobbs, Lisena Hasanaj, Prin Amorapanth, John-Ross Rizzo, Rachel Nolan, Liliana Serrano, Jenelle Raynowska, Janet C Rucker, Barry D Jordan, Steven L Galetta, Laura J Balcer
OBJECTIVE: This study introduces a rapid picture naming test, the Mobile Universal Lexicon Evaluation System (MULES), as a novel, vision-based performance measure for concussion screening. The MULES is a visual-verbal task that includes 54 original photographs of fruits, objects and animals. We piloted MULES in a cohort of volunteers to determine feasibility, ranges of picture naming responses, and the relation of MULES time scores to those of King-Devick (K-D), a rapid number naming test...
November 4, 2016: Journal of the Neurological Sciences
Hiroshi Nagayama, Tetsuya Maeda, Tsuyoshi Uchiyama, Masaya Hashimoto, Nobuatsu Nomoto, Osamu Kano, Tatsuya Takahashi, Hiroo Terashi, Shinsuke Hamada, Takafumi Hasegawa, Taku Hatano, Tetsuya Takahashi, Yasuhiko Baba, Renpei Sengoku, Hirohisa Watanabe, Manabu Inoue, Taro Kadowaki, Satoshi Kaneko, Hideki Shimura, Shin-Ichiro Kubo
Anhedonia is one of the non-motor symptoms observed in the Parkinson's disease (PD). However, there is no clear relationship between anhedonia and its correlation with other symptoms of PD. The aim of this study is to evaluate the characteristics of anhedonia and its correlation with clinical aspects of PD in a relatively large cohort. We enrolled 318 patients with PD and 62 control subjects for this study. Patients and subjects were tested using the Snaith-Hamilton Pleasure Scale Japanese version and the Beck Depression Inventory 2nd edition for the assessment of anhedonia and depression...
November 3, 2016: Journal of the Neurological Sciences
Hiroaki Yaguchi, Akiko Takeuchi, Kazuhiro Horiuchi, Ikuko Takahashi, Shinnichi Shirai, Sachiko Akimoto, Katsuya Satoh, Fumio Moriwaka, Ichiro Yabe, Hidenao Sasaki
No abstract text is available yet for this article.
November 3, 2016: Journal of the Neurological Sciences
Aline Silva de Miranda, Cun-Jin Zhang, Atsuko Katsumoto, Antônio Lúcio Teixeira
Adult hippocampal neurogenesis involves proliferation, survival, differentiation and integration of newborn neurons into pre-existing neuronal networks. Although its functional significance in the central nervous system (CNS) has not comprehensively elucidated, adult neurogenesis has been attributed a role in cognition, learning and memory. There is a growing body of evidence that CNS resident as well as peripheral immune cells participate in regulating hippocampal adult neurogenesis. Microglial cells are closely associated with neural stem/progenitor cell (NSPC) in the neurogenic niche engaged in a bidirectional communication with neurons, which may be important for adult neurogenesis...
November 3, 2016: Journal of the Neurological Sciences
Javier Riancho, Yesica Jiménez-López, José Ramón Sánchez-de la Torre, Lara Pardina-Vilella, Pascual Sánchez-Juan
No abstract text is available yet for this article.
November 3, 2016: Journal of the Neurological Sciences
Emre Kumral, Oral Zirek
BACKGROUND AND PURPOSE: Major cognitive disorder (MND) following vascular events is known as second causes of dementia after Alzheimer's disease (AD). Acute onset MND due to isolated hippocampal infarction has not been recognized as a specific subtype of vascular dementia, and there is no validated criteria for the identification of such cases, either clinically or radiologically. RESULTS: Among 7200 patients with first-ever ischemic stroke, 22 patients (0.3%) showed acute isolated ischemic lesions in the hippocampus...
November 3, 2016: Journal of the Neurological Sciences
Paurush Ambesh, Vimal Kumar Paliwal, Vijay Shetty, Stephan Kamholz
The Babinski Sign is one of the most clinically relevant diagnostic signs in medicine. Though the plantar reflex is practiced thousands of times across the globe every day, few realize its historical importance. In this narrative review we trace the origins of the Plantar Reflex back in the 19th century, discuss its evolution over time and examine the body of evidence behind the current understanding. State of the art diagnostic modalities like video analysis and electromyography have helped us in dissecting the pathophysiology behind the simple yet beautiful Babinski Sign...
November 2, 2016: Journal of the Neurological Sciences
Demetrios Moris, Chris Bakoyiannis, Georgios Karaolanis, Sotirios Georgopoulos
No abstract text is available yet for this article.
November 1, 2016: Journal of the Neurological Sciences
Sandeep Kumar, Sarah Marchina, Joseph Massaro, Wayne Feng, Sourabh Lahoti, Magdy Selim, Shoshana J Herzig
BACKGROUND: Pneumonia is a serious but a preventable stroke complication. Prediction scales for post-stroke pneumonia have been proposed with an intent to improve surveillance and prevention but they remain under-utilized in clinical practice. Most existing scales were developed using both ventilated and non-ventilated patients which may affect their accuracy. We derived and validated a novel, pragmatic scale to predict hospital-acquired pneumonia (HAP) after stroke employing only a non-ventilated stroke cohort...
November 1, 2016: Journal of the Neurological Sciences
Benjamin Hebant, Evelyne Guegan-Massardier, Valérie Macaigne, Aude Triquenot-Bagan
No abstract text is available yet for this article.
November 1, 2016: Journal of the Neurological Sciences
Yingting Wang, Huan Cai, Guoqing Zhou, Zhizhong Zhang, Xinfeng Liu
No abstract text is available yet for this article.
November 1, 2016: Journal of the Neurological Sciences
Francesca Rosini, Valeria Serchi, Letizia Tirelli, Lara Di Toro Mammarella, Barbara Pucci, Antonio Federico, Alessandra Rufa
No abstract text is available yet for this article.
October 31, 2016: Journal of the Neurological Sciences
Yuko Wada, Yo Nishimura, Misa Ishihara, Kimio Hashimoto, Norihiro Takenouchi, Toru Yamamoto
No abstract text is available yet for this article.
October 29, 2016: Journal of the Neurological Sciences
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