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Journal of the Neurological Sciences

Peter S Spencer, Rajarshi Mazumder, Valerie S Palmer
No abstract text is available yet for this article.
October 13, 2016: Journal of the Neurological Sciences
R Colebunders, P Suykerbuyk, S T Jacob, M van Oijen
No abstract text is available yet for this article.
October 8, 2016: Journal of the Neurological Sciences
Nadine Lilla, Jasmin Hartmann, Stefan Koehler, Ralf-Ingo Ernestus, Thomas Westermaier
A lack of nitric oxide (NO) may be a possible factor in the pathogenesis of an acute decrease of cerebral blood flow (CBF) after subarachnoid hemorrhage (SAH). This study was conducted to investigate whether early therapy with an NO-donor can improve CBF and offer neuroprotection after experimental SAH in rats. Male Sprague-Dawley rats were subjected to SAH by the endovascular filament model and treated with 1.5μg/kg/min of intravenous sodium nitroprusside (SNP) or vehicle (n=10) starting 15min after induction of SAH until 180min thereafter...
September 20, 2016: Journal of the Neurological Sciences
Catharina Conzen, Gerrit Alexander Schubert
No abstract text is available yet for this article.
September 20, 2016: Journal of the Neurological Sciences
William V Padula
No abstract text is available yet for this article.
September 13, 2016: Journal of the Neurological Sciences
David V Walsh, José E Capó-Aponte, Thomas Beltran, Wesley R Cole, Ashley Ballard, Joseph Y Dumayas
OBJECTIVES: The Department of Defense reported that 344,030 cases of traumatic brain injury (TBI) were clinically confirmed from 2000 to 2015, with mild TBI (mTBI) accounting for 82.3% of all cases. Unfortunately, warfighters with TBI are often identified only when moderate or severe head injuries have occurred, leaving more subtle mTBI cases undiagnosed. This study aims to identify and validate an eye-movement visual test for screening acute mTBI. METHODS: Two-hundred active duty military personnel were recruited to perform the King-Devick® (KD) test...
September 11, 2016: Journal of the Neurological Sciences
Joerg-Patrick Stübgen
The inflammatory myopathies comprise a group of immune-mediated muscle diseases. Lymphoma is a term for a variety of lymphatic system malignancies. Autoimmune diseases and lymphoproliferative malignancies share a complex bidirectional relationship. A causal relationship between inflammatory mypathies and lymphoma has not been established. The diagnosis/treatment of inflammatory myopathy usually precedes the detection/diagnosis of lymphoma. Immune system dysregulation presumably underlies the evolution of lymphoma in patients with inflammatory myopathies...
October 15, 2016: Journal of the Neurological Sciences
Arata Abe, Yuki Sakamoto, Akane Nogami, Koichiro Nagai, Shiro Takahashi, Madoka Kajio, Chikako Nito, Kazumi Kimura
No abstract text is available yet for this article.
October 15, 2016: Journal of the Neurological Sciences
Robin Souron, Adrien Farabet, Guillaume Y Millet, Thomas Lapole
This study aimed to evaluate the intra- and inter-day reliability of transcranial magnetic stimulation (TMS)-related measurements recorded from the tibialis anterior (TA) muscle. Thirteen healthy young men and women (23±4years) performed 3 testing sessions to assess intra- (i.e., two sessions performed the same day) and inter-day (i.e. two sessions performed one week apart) reliability of (i) dorsiflexion cortical maximal voluntary activation level (VATMS), (ii) TA corticospinal excitability assessed through the amplitude of the motor evoked potentials (MEP) recorded during 100, 75 and 50% maximal voluntary contractions (MVC), and (iii) intracortical inhibition investigated via the cortical silent period (CSP) recorded at the same % MVC...
October 15, 2016: Journal of the Neurological Sciences
Meihua Shen, Danfeng Fan, Yu Zang, Yan Chen, Kaimin Zhu, Zhonghai Cai, Yueqin Liu, Xuejun Sun, Jiankang Liu, Jianfeng Gong
BACKGROUND: Methane has been reported to play a protective role in ischemia-reperfusion injury via anti-oxidation, anti-inflammatory and anti-apoptotic activities. This study was designed to determine the protective effects of methane-rich saline (MRS) on acute carbon monoxide (CO) poisoning. METHODS: A total of 36 male Sprague-Dawley rats were randomly divided into 3 groups: sham group, CO group and MRS group. Acute CO poisoning was induced by exposing rats to 1000ppm CO in air for 40min and then to 3000ppm CO for an additional 20min until they lost consciousness...
October 15, 2016: Journal of the Neurological Sciences
Liborio Rampello, Luigi Rampello, Francesco Patti, Mario Zappia
Motor speech disorders are common in a number of neurological conditions including diseases involving impairment of the pyramidal, extrapyramidal, and cerebellar pathways, cranial nerves, muscular apparatus, neuromuscular plaque, and of cognitive, symbolic and mnestic activities. The diagnosis of speech disorders, namely the dysarthrias, involves the assessment of characteristic structural cerebral, prosodic, phonetic and phonemic changes, often flanked by concomitant functional, clinical, neuroradiological, neurophysiological and behavioral impairment...
October 15, 2016: Journal of the Neurological Sciences
Youwen Zhang, Shujun Feng, Kun Nie, Xin Zhao, Rong Gan, Limin Wang, Jiehao Zhao, Hongmei Tang, Liang Gao, Ruiming Zhu, Lijuan Wang, Yuhu Zhang
OBJECTIVE: The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been proposed to be associated with increased risk of Parkinson's disease (PD) and have a specific impact on dopamine-mediated prefrontal executive function in an inverted-U curve manner. We explored the influence of this genetic polymorphism on prefrontal executive function in a well-established Chinese cohort of early PD patients with no current or past history of motor fluctuations or dyskinesias. METHODS: Cognitive functions were assessed in 250 patients with early PD using Wechsler Adult Intelligence Scale-Chinese Revision (WAIS-RC) and Wechsler Memory Scale-Chinese Revision (WMS-RC)...
October 15, 2016: Journal of the Neurological Sciences
Benjamin Berger, Rick Dersch, Elisabeth Ruthardt, Christiane Rasiah, Sebastian Rauer, Oliver Stich
OBJECTIVES: Anti-SOX1 antibodies are associated with small cell lung cancer (SCLC) and predict a paraneoplastic etiology in Lambert-Eaton myasthenic syndrome (LEMS). In 2010, a study described these antibodies in a small cohort of putative non-paraneoplastic, immune-mediated neuropathies. In this respect, we investigated the seroprevalence and specificity of anti-SOX1 antibodies in a large cohort of neurological disorders. METHODS: Overall, serum samples of 1493 consecutive patients were screened for anti-SOX1 reactivity by an ELISA: 471 with well-defined neurological disorders (multiple sclerosis, motor neuron disease, Guillain-Barré syndrome, and chronic inflammatory demyelinating polyneuropathy), 185 with polyneuropathy (PNP) of unknown origin, and 837 with neurological syndromes of suspicious paraneoplastic etiology...
October 15, 2016: Journal of the Neurological Sciences
Francesco Cerritelli, Nuria Ruffini, Eleonora Lacorte, Nicola Vanacore
OBJECTIVE: The aim of the present systematic review is to critically evaluate the effectiveness of OMT as an adjuvant therapy in the management of patients with neurological diseases. METHODS: A systematic review was conducted and the findings were reported following the PRISMA statement. Twelve databases were searched for articles reporting the use of osteopathic manipulative treatment in neurological disorders. Each article was assessed using the Cochrane risk of bias tool and the Jadad score...
October 15, 2016: Journal of the Neurological Sciences
Ali A Asadi-Pooya, Amin H Rabiei, Edward J Gracely, Michael R Sperling
OBJECTIVES: Tonic-clonic seizures are associated with greater chance of seizure relapse after anterior temporal lobectomy. We investigated whether the interval between the last preoperative tonic-clonic seizure and surgery relates to seizure outcome in patients with drug-resistant mesial temporal lobe epilepsy (MTLE). METHODS: In this retrospective study, patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was categorized as seizure freedom or relapse...
October 15, 2016: Journal of the Neurological Sciences
Gregoire Boulouis, Andreas Charidimou, Eitan Auriel, Kellen E Haley, Ellis S van Etten, Panagiotis Fotiadis, Yael Reijmer, Alison Ayres, Kristin M Schwab, Sergi Martinez-Ramirez, Jonathan Rosand, Anand Viswanathan, Joshua N Goldstein, Steven M Greenberg, M Edip Gurol
BACKGROUND: The association between cerebral small vessel diseases (cSVD) and intracranial atherosclerosis is debated and conflicting results have been reported. We sought to investigate this association in patients with intracerebral hemorrhage (ICH), due to severe cSVD. METHODS: Consecutive ICH patients were divided into those meeting criteria for cerebral amyloid angiopathy (CAA) and those with deep hypertensive ICH consistent with hypertensive cSVD (HTN-SVD)...
October 15, 2016: Journal of the Neurological Sciences
Marzieh Khani, Hosein Shamshiri, Afagh Alavi, Shahriar Nafissi, Elahe Elahi
We aimed to identify the genetic cause of neurological disease in an Iranian pedigree whose manifestations suggested hereditary motor and sensory neuropathy with proximal predominance (HMSN-P). Identification of a p.Gly269Val mutation in TFG, the known HMSN-P causative gene, provided supportive evidence. Subjective, biochemical, electrodiagnostic, and imaging data were compared with previously reported HMSN-P patients, including patients of an earlier described Iranian pedigree. Although notable clinical variability was found, comparable involvement of proximal and distal muscles was observed in both Iranian pedigrees...
October 15, 2016: Journal of the Neurological Sciences
Abdulbaset H Kamour, Dong Y Han, David M Mannino, Amy B Hessler, Sachin Kedar
PURPOSE: There is a national shortage of physicians in brain related specialties (neurology, neurosurgery and psychiatry), with fewer students training in these specialties. This study explored socio-economic and experiential factors that determined medical trainees' interest in brain related specialties. METHOD: Medical students and house-staff at a state university medical school completed a 46-item questionnaire sent as an anonymous email survey. RESULTS: Survey response rate was 22% (n=258)...
October 15, 2016: Journal of the Neurological Sciences
Harry J Gould, Ivan Diamond
No abstract text is available yet for this article.
October 15, 2016: Journal of the Neurological Sciences
Itzhak Kimiagar, Shani Kalmanovich-Avnery, Ofer M Gonen, Zvika Sacagiu, Evelina Shevtzov, Ronen Levite, Jochay Weinstein, Avigail Bartal, Rina Aroesty, Sarah Bhonkar, Sigal Tal, Youval Leonov, Alex Blatt, Zoya Haitov, Samuel Bar-Hayim, Carmel Armon
BACKGROUND: Use of TPA to treat patients with acute ischemic stroke was introduced in Assaf Harofeh Medical Center (AHMC) in Israel in November 2007 initially with strict adherence to the inclusion/exclusion criteria of the pivotal NINDS TPA studies published in 1995. The treatment window was expanded in 2010 to 4.5h following the results of ECASS-III. Application of the 2013 AHA/ASA Guidelines resulted in further expanded inclusion and relaxed exclusion criteria. DESIGN/METHODS: A retrospective chart review was conducted of patients who received TPA at AHMC to evaluate the additional impact of applying the 2013 guidelines...
October 15, 2016: Journal of the Neurological Sciences
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