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Journal of the Neurological Sciences

Christine Tomkinson, Jian-Qiang Lu
No abstract text is available yet for this article.
September 7, 2018: Journal of the Neurological Sciences
Masamichi Ikawa, Hirohiko Kimura, Yuki Kitazaki, Katsuya Sugimoto, Akiko Matsunaga, Kouji Hayashi, Osamu Yamamura, Tetsuya Tsujikawa, Tadanori Hamano, Makoto Yoneda, Hidehiko Okazawa, Yasunari Nakamoto
PURPOSE: The aim of this study was to evaluate the clinical utility of arterial spin labeling (ASL) magnetic resonance imaging (MRI) for the detection of cerebellar hypoperfusion in patients with spinocerebellar degeneration (SCD). METHODS: Regional cerebral blood flow (CBF) were obtained from ASL and 123 I-IMP single-photon emission computed tomography (SPECT) images by volume-of-interest analysis in patients with SCD (n = 16). Regional CBF were also measured by ASL in age-matched controls (n = 19) and by SPECT in separate controls (n = 17)...
September 6, 2018: Journal of the Neurological Sciences
Tomoyuki Kawada
No abstract text is available yet for this article.
September 5, 2018: Journal of the Neurological Sciences
Diana Cantero, Aurelio Hernández-Laín, Juan Francisco Gonzalo Martínez, María Rabasa Pérez, Yolanda Ruano, Cinta Lleixà, Eduard Gallardo, Cristina Domínguez-González
INTRODUCTION: Sarcoglycanopathies (LGMD 2C2F) are a subgroup of limb-girdle muscular dystrophies (LGMD), caused by mutations in sarcoglycan genes. They usually have a childhood onset and rapidly progressive course with loss of ability to walk over 12-16 years. METHODS: Next generation sequencing (NGS) targeted gene panel was performed in three adult patients with progressive muscle weakness in which routine muscle histology and immunohistochemistry were not diagnostic...
September 5, 2018: Journal of the Neurological Sciences
Alexandre Roux, Marc Zanello, Johan Pallud
No abstract text is available yet for this article.
September 5, 2018: Journal of the Neurological Sciences
Callum G Brownstein, Paul Ansdell, Jakob Škarabot, Glyn Howatson, Stuart Goodall, Kevin Thomas
The study aimed to determine the optimal application of single- and paired-pulse transcranial magnetic stimulation (TMS) in the rectus femoris. Twenty-nine male adults participated in the study, which involved 5 separate experiments. Experiments 1 to 3 assessed the effect of conditioning stimulus (CS) intensity (60, 70, 80 and 90% active motor threshold, AMT), contraction strength (5, 10, 20 and 50% maximum voluntary contraction, MVC), and inter-stimulus interval (ISI, 2-5 ms for short-interval intracortical inhibition, SICI and 10-15 ms for intracortical facilitation, ICF) on SICI and ICF...
September 5, 2018: Journal of the Neurological Sciences
Laura de Godoy Rousseff Prado, Natalia Pessoa Rocha, Leonardo Cruz de Souza, Isabella Carolina Santos Bicalho, Rodrigo Santiago Gomez, Mauro Vidigal-Lopes, Nayara Felicidade Tomaz Braz, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira
OBJECTIVE: To evaluate potential associations between clinical features and inflammatory markers in patients with amyotrophic lateral sclerosis (ALS). METHODS: A consecutive series of 68 patients (39 males and 29 females) with sporadic ALS were subjected to a comprehensive clinical assessment and blood draw. A subset of these patients underwent a new assessment within 6-12 months after the baseline visit. In addition, a group of 62 subjects composed by age and sex-matched healthy subjects (38 males and 24 females) was enrolled in this study...
September 4, 2018: Journal of the Neurological Sciences
Hirotaka Iwaki, Katherine C Hughes, Xiang Gao, Michael A Schwarzschild, Alberto Ascherio
BACKGROUND: Previous studies regarding the association between restless legs syndrome (RLS) and Parkinson's disease (PD) have produced contradictory results. However, the time frame between them has varied across these studies, and also, the longitudinal trajectroy of RLS symptoms has not been considered. OBJECTIVE: To investigate if transient or continuous/recurrent RLS identified by questionnaire are associated with the premotor symptoms of PD. METHODS: The study population comprised 16,636 men in the Health Professional Follow-Up Study, who answered questions regarding RLS symptoms in both 2002 and 2008, and were not diagnosed with PD...
September 1, 2018: Journal of the Neurological Sciences
Albert Stezin, Soumya D Venkatesh, Kandavel Thennarasu, Meera Purushottam, Sanjeev Jain, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: To evaluate the non-ataxic clinical manifestations in genetically proven Spinocerebellar ataxia 2 (SCA2) and identify their determinants and predictors. METHODS: Seventy-three subjects with genetically proven SCA2 were evaluated clinically for the common non-ataxic manifestations. Based on the presence or absence of non-ataxic manifestations, patients were classified into groups and then compared for significant differences in the CAG repeat length, age at onset (AAO), duration of disease, and ataxia rating score...
September 1, 2018: Journal of the Neurological Sciences
Palaniswamy Ramaswamy, Rita Christopher, Pramod Kumar Pal, Ravi Yadav
Parkinsonian disorders are a set of progressive neurodegenerative movement disorders characterized by rigidity, tremor, bradykinesia, postural instability and their distinction has significant implications in terms of management and prognosis. Parkinson's disease (PD) is the most common among them. Its clinical diagnosis is challenging and, it can be misdiagnosed in the early stages. Multiple system atrophy and progressive supranuclear palsy are the close mimickers in early stages, due to overlapping clinical features...
August 31, 2018: Journal of the Neurological Sciences
Marcus V Pinto, P James B Dyck, Linde E Gove, Bryan M McCauley, Elizabeth J Ackermann, Steven G Hughes, Marcia Waddington-Cruz, Peter J Dyck
OBJECTIVE: Report on the kind and distribution of somatotopic sensation loss and its utility in assessing severity of sensation loss in study of a large international cohort of patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN). METHODS: Smart Somatotopic Quantitative Sensation Testing (S ST QSTing) using Computer Assisted Sensation Evaluator IVc (CASE IVc) was used to assess the somatotopic distribution of touch pressure (TP) and heat pain (HP) sensation loss twice of untreated hATTR-PN patients in the Ionis NEURO-TTR trial (www...
August 30, 2018: Journal of the Neurological Sciences
Mao Mukai, Ikuko Mizuta, Akihiko Ueda, Daisuke Nakashima, Yukie Kushimura, Yu-Ichi Noto, Tomoyuki Ohara, Kyoko Itoh, Yukio Ando, Toshiki Mizuno
No abstract text is available yet for this article.
August 29, 2018: Journal of the Neurological Sciences
Si-da Xi, Yu-Lan Zhu, Chan Chen, Han-Qiu Liu, Wei-Wei Wang, Fang Li
Botulinum neurotoxin A (BTX-A) intervention has long-term benefits for children with obstetric brachial plexus palsy (OBPP). Although cortical plasticity has been widely studied, plasticity in white matter has not received as much attention. Here, six children with OBPP underwent functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) before and 6 months after BTX-A treatment. Surface electromyography (EMG) was recorded. The aim was to investigate changes in the corticospinal tract (CST) as an example longitudinal observation of white matter plasticity...
August 28, 2018: Journal of the Neurological Sciences
Martinsixtus Ezejimofor, Amabetare Biu, Olalekan A Uthman
PURPOSE: This study aims to estimate the computed tomography (CT) and Magnetic resonance imaging (MRI) uptake, stroke subtypes and 30-days case-fatality in Nigeria. METHODS: Stroke diagnosis and mortality data were identified from relevant databases. A random effect meta-analysis was conducted to obtain the pooled percentage uptake of CT/MRI, including 30-days case fatality and a meta-regression-like epidemiological model was applied on all data points. FINDINGS: A total of 24 studies involving 5874 stroke patients conducted in predominantly tertiary referral hospitals met the inclusion criteria...
August 24, 2018: Journal of the Neurological Sciences
Pavel Krupenin, Mariia Gabitova, Sergey Bordovsky, Yana Kirichuk, Dmitry Napalkov, Irina Preobrazhenskaya, Anastasiya Sokolova
Mild cognitive impairment (MCI) in patients with cardiovascular risks is a transitional state to vascular dementia but which still has a possibility of being managed. The objectives of this study were to assess the impact of atrial fibrillation (AF) on cognitive performances in the elderly in comparison with similar cardiovascular risks. One hundred unselected patients were included in AF+ and AF- groups. Patients with prodromal Alzheimer disease as shown by semantic cueing test, and those suffering from major cognitive decline according to DSM 5 criteria were evaluated separately from those patients analysed for vascular cognitive impairment...
August 23, 2018: Journal of the Neurological Sciences
Meagan Seay, Omar Akhand, Matthew S Galetta, Lucy Cobbs, Lisena Hasanaj, Prin Amorapanth, John-Ross Rizzo, Rachel Nolan, Liliana Serrano, Janet C Rucker, Steven L Galetta, Laura J Balcer
OBJECTIVE: The Mobile Universal Lexicon Evaluation System (MULES) is a test of rapid picture naming that is under investigation for concussion. MULES captures an extensive visual network, including pathways for eye movements, color perception, memory and object recognition. The purpose of this study was to introduce the MULES to visual assessment of patients with MS, and to examine associations with other tests of afferent and efferent visual function. METHODS: We administered the MULES in addition to binocular measures of low-contrast letter acuity (LCLA), high-contrast visual acuity (VA) and the King-Devick (K-D) test of rapid number naming in an MS cohort and in a group of disease-free controls...
August 23, 2018: Journal of the Neurological Sciences
Chloe Laurencin, Solveig Montaut, Christophe Vial, Lorraine Bernard, Sylvie Bin, Lucie Rascle, Gustavo Polo, Patrick Mertens, Teodor Danaila, Stephane Thobois
BACKGROUND: Off state toe dystonia (TD) is a symptom frequently encountered in Parkinson's disease (PD), but little is known about its evolution after subthalamic nucleus deep brain stimulation (STN-DBS). OBJECTIVE: To analyze the prevalence and the evolution of TD in PD patients candidate to STN-DBS. METHODS: Individual data of consecutive 130 PD patients who underwent STN-DBS between 2010 and 2015 were collected. RESULTS: Data were successfully collected in 95 patients...
July 12, 2018: Journal of the Neurological Sciences
Pu Wang, Xiangdong Luo, Chengqing Zhong, Lili Yang, Fuqiang Guo, Nengwei Yu
Essential tremor (ET) is one of the most common movement disorders in humans. Nevertheless, there remain several controversies surrounding ET, such as whether it is a disorder of abnormal neuronal oscillations within the tremor network. In this work, the resting-state fMRI data were collected from 17 ET patients and 17 age- and gender-matched healthy controls. First, using FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) the abnormal synchronization of fMRI signals in ET patients were investigated...
July 10, 2018: Journal of the Neurological Sciences
Koh Tadokoro, Yasuyuki Ohta, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Kazufumi Nakamura, Ichizo Nishino, Koji Abe
No abstract text is available yet for this article.
October 15, 2018: Journal of the Neurological Sciences
H Argente-Escrig, J C Martinez, E Gómez, A Balaguer, T Sevilla, L Bataller
No abstract text is available yet for this article.
October 15, 2018: Journal of the Neurological Sciences
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