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Journal of the Neurological Sciences

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https://www.readbyqxmd.com/read/28202200/response-to-the-letter-to-the-editor-for-the-manuscript-focal-muscle-vibration-an-effective-rehabilitative-approach-in-severe-gait-impairment-due-to-multiple-sclerosis-by-nardone-et-al
#1
LETTER
F Camerota, A Suppa, C De Fino, C Celletti, V Nociti
No abstract text is available yet for this article.
February 9, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28202199/effects-of-focal-muscle-vibration-on-corticospinal-excitability
#2
LETTER
Raffaele Nardone, Stefan Golaszewski, Monica Christova, Eugen Gallasch, Francesco Brigo, Eugen Trinka
No abstract text is available yet for this article.
February 9, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28196747/socs-gene-family-expression-profile-in-the-blood-of-multiple-sclerosis-patients
#3
Mehdi Toghi, Mohammad Taheri, Shahram Arsang-Jang, Mina Ohadi, Reza Mirfakhraie, Mehrdokht Mazdeh, Arezou Sayad
Multiple sclerosis (MS) is a chronic autoimmune disease, and the most common cause of nontraumatic disability in young people. The etiology of this disease is not well defined yet. Cytokines play an important role in differentiation, maturation and survival of a wide range of cells, including cells of the immune system. Suppressor of cytokine signaling (SOCS) proteins are the most important regulators of this cytokine signaling pathway. The aim of present study was to compare the expression levels of SOCS1, SOCS2, SOCS3 and SOCS5 genes in the blood of 50 relapsing-remitting MS (RR-MS) patients and 50 healthy controls by Taqman Quantitative Real-Time PCR in patients and healthy control group...
February 9, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28131391/new-hearts-for-friedreich-patients
#4
David Pleasure
No abstract text is available yet for this article.
January 12, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28109580/cardiac-transplantation-in-friedreich-ataxia-extended-follow-up
#5
Ashley McCormick, Julianna Shinnick, Kim Schadt, Rose Rodriguez, Linda Addonizio, Michio Hirano, Susan Perlman, Kimberly Y Lin, David R Lynch
Friedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder most commonly caused by guanine-adenine-adenine (GAA) trinucleotide repeat expansions in both alleles of the FXN gene. Although progressive ataxia remains the hallmark clinical feature, patients with FRDA are at high risk of developing cardiomyopathy, often resulting in premature death. There is no specific treatment for FRDA-associated cardiomyopathy; even in advanced cardiac failure cardiac transplantation is not commonly pursued...
January 10, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28104233/wrong-diagnosis-in-the-supposed-self-portrait-of-el-greco
#6
LETTER
Enrique Santos-Bueso, A Arteaga-Sánchez, J Porta-Etessam, J M Vinuesa-Silva, J García-Sánchez
No abstract text is available yet for this article.
January 10, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28094010/el-greco-depicted-his-own-neurological-disabilities
#7
LETTER
R Bianucci, F Marías Franco, O Appenzeller
No abstract text is available yet for this article.
January 10, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28126343/management-of-impulse-control-disorders-with-deep-brain-stimulation-a-double-edged-sword
#8
REVIEW
Chayut Kasemsuk, Genko Oyama, Nobutaka Hattori
Deep brain stimulation (DBS) is a surgical option for advanced Parkinson's disease. Although DBS is used to treat motor fluctuation, DBS may affect non-motor symptoms including mood disorders, cognitive dysfunction, and behavior problems. Impulse control disorders (ICDs) are abnormal behaviors with various manifestations such as pathological gambling, hypersexuality, compulsive shopping, and binge eating, which can affect the quality of life in patients with Parkinson's disease. The effect of DBS on ICD is controversial...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28126342/the-sleeping-brain-in-parkinson-s-disease-a-focus-on-rem-sleep-behaviour-disorder-and-related-parasomnias-for-practicing-neurologists
#9
REVIEW
Roongroj Bhidayasiri, Jirada Sringean, Watchara Rattanachaisit, Daniel D Truong
Sleep disorders are identified as common non-motor symptoms of Parkinson's disease (PD) and recently this recognition has been expanded to include parasomnias, encompassing not only REM sleep behaviour disorder (RBD), but also other non-REM forms. RBD, a prototypical parasomnia in PD, exists even in the prodromal stage of the disease, and is characterized by the presence of dream enactment behaviours occurring alongside a loss of normal skeletal muscle atonia during REM sleep. In contrast, non-REM parasomnias are more frequently observed in the late stage PD...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28109579/reprint-of-neuropsychiatric-symptoms-behavioural-disorders-and-quality-of-life-in-parkinson-s-disease
#10
REVIEW
Roberta Balestrino, Pablo Martinez-Martin
Parkinson's disease is a complex neurodegenerative disorder characterized by motor and non-motor symptoms, with neuropsychiatric manifestations among the most frequent non-motor symptoms. Health-related quality of life is a patient-reported outcome that reflects the impact of the disease on physical, mental, and social wellbeing, and on other aspects of patient' life. Although older studies on health-related quality of life in Parkinson's disease mainly investigated the role of the motor impairment, recent research focused on non-motor symptoms has highlighted the critical role that behavioural disturbances due to neuropsychiatric symptoms play in determining health related quality of life...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28108021/phenomenology-and-epidemiology-of-impulsive-compulsive-behaviours-in-parkinson-s-disease-atypical-parkinsonian-disorders-and-non-parkinsonian-populations
#11
REVIEW
Eimer M Maloney, Atbin Djamshidian, Sean S O'Sullivan
Impulsive-compulsive behaviours are common, quality of life affecting consequences of dopamine replacement therapy which are well recognized in patients with idiopathic Parkinson's disease. Details of the occurrence and nature of these disorders in the atypical parkinsonian neurodegenerative disorders, and in non-Parkinson's patients prescribed dopaminergic stimulation for other disease processes, are slowly emerging. Here we review what is known about the phenomenology, epidemiology and risk factors for impulsive-compulsive behaviours in Parkinson's disease and in other, less well studied, patient groups...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28108020/hallucinations-and-the-spectrum-of-psychosis-in-parkinson-s-disease
#12
REVIEW
Karen Frei, Daniel D Truong
Hallucinations and psychosis can be a part of Parkinson's disease and are considered to be a nonmotor symptom or a neuropsychiatric complication of the disease. Hallucinations of different modalities and delusions can occur beyond the common visual hallucinations. The various types of hallucinations and psychotic symptoms comprising the spectrum of Parkinson's disease psychosis is the subject of this review article.
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28104234/knowledge-attitudes-and-perceptions-of-parkinson-s-disease-a-cross-sectional-survey-of-asian-patients
#13
Onanong Jitkritsadakul, Nonglak Boonrod, Roongroj Bhidayasiri
BACKGROUND: A knowledge gap about Parkinson's disease (PD) often exists amongst PD patients, the level and accuracy of which can influence their attitude and perceptions about the disease. Increased awareness of this information deficit can help physicians identify interventions that will improve patient's knowledge and perceptions about PD. OBJECTIVES: To evaluate general understanding of PD and identify knowledge gaps amongst PD patients using a validated PD knowledge questionnaire...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28104232/dopamine-agonist-withdrawal-syndrome-a-comprehensive-review
#14
REVIEW
Xin Xin Yu, Hubert H Fernandez
Dopamine agonists are effective and widely used treatments for Parkinson disease (PD). However, patients on dopamine agonists may experience significant side effects which necessitate dose tapering or discontinuation. Dopamine agonist withdrawal syndrome (DAWS) is a complication that affects up to 19% of PD patients who undergo a dopamine agonist taper. It was initially described in 2010 as a severe stereotypical cluster of psychiatric and physical symptoms occurring with dopamine agonist withdrawal. Identified risk factors for DAWS include impulse control behavior disorders (ICD) and higher dopamine agonist dosage...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28089250/pathology-of-behavior-in-pd-what-is-known-and-what-is-not
#15
REVIEW
Kaylena A Ehgoetz Martens, Simon J G Lewis
Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28088312/dementia-in-parkinson-s-disease
#16
REVIEW
Hasmet A Hanagasi, Zeynep Tufekcioglu, Murat Emre
Dementia can occur in a substantial number of patients with Parkinson's disease with a point prevalence close to 30%. The cognitive profile is characterized by predominant deficits in executive, visuospatial functions, attention and memory. Behavioral symptoms are frequent such as apathy, visual hallucinations and delusions. The most prominent associated pathology is Lewy body-type and biochemical deficit is cholinergic. Placebo-controlled randomized trials with cholinesterase inhibitors demonstrated modest but significant benefits in cognition, behavioral symptoms and global functions...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087061/editorial-and-introduction-behavioral-aspects-of-parkinson-s-disease
#17
EDITORIAL
Joseph H Friedman, Roongroj Bhidayasiri, Daniel D Truong
No abstract text is available yet for this article.
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087060/personality-in-parkinson-s-disease-clinical-behavioural-and-cognitive-correlates
#18
REVIEW
Gabriella Santangelo, Fausta Piscopo, Paolo Barone, Carmine Vitale
Affective disorders and personality changes have long been considered pre-motor aspects of Parkinson's disease (PD). Many authors have used the term "premorbid personality" to define distinctive features of PD patients' personality characterized by reduced exploration of new environmental stimuli or potential reward sources ("novelty seeking") and avoidance behaviour ("harm avoidance") present before motor features. The functional correlates underlying the personality changes described in PD, implicate dysfunction of meso-cortico-limbic and striatal circuits...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087059/fatigue-in-parkinson-s-disease
#19
REVIEW
Karen Herlofson, Benzi M Kluger
Fatigue is one of the most common nonmotor symptoms in Parkinson's disease and may affect a wide range of everyday activities, cause disability and reduce quality of life. It occurs at every stage of PD, and once present will often persist and may worsen over time. Lack of a consensus of definition and classification, and a range of different self-reporting scales has so far made the study of fatigue challenging. We review a unifying taxonomy for defining fatigue in clinical and research contexts as well as case definition criteria for PD-related fatigue...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28073433/misperceptions-and-parkinson-s-disease
#20
REVIEW
Joseph H Friedman
Most of the neurobehavioral aspects of Parkinson's disease have been well established and studied, but many are not well known, and hardly studied. This article focuses on several behavioral abnormalities that are common, and frequently cause difficulty for the patient and family due to lack of recognition as part of the disease. While it is well known that L-Dopa dyskinesias are frequently not recognized or under appreciated by patients, a similar lack of recognition may affect the patient's own speech volume, where their center of gravity is located, whether they are tilted to one side, and their under-recognition of others' emotional displays...
March 15, 2017: Journal of the Neurological Sciences
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