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Journal of the Neurological Sciences

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https://www.readbyqxmd.com/read/28094010/el-greco-depicted-his-own-neurological-disabilities
#1
LETTER
R Bianucci, F Marías Franco, O Appenzeller
No abstract text is available yet for this article.
January 10, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28088313/q-space-myelin-map-imaging-for-longitudinal-analysis-of-demyelination-and-remyelination-in-multiple-sclerosis-patients-treated-with-fingolimod-a-preliminary-study
#2
Mariko Tanikawa, Jin Nakahara, Junichi Hata, Shigeaki Suzuki, Kanehiro Fujiyoshi, Hirokazu Fujiwara, Suketaka Momoshima, Masahiro Jinzaki, Masaya Nakamura, Hideyuki Okano, Shinichi Takahashi, Norihiro Suzuki
BACKGROUND: Fingolimod (FTY) is an oral sphingosine-1-phosphate receptor modulator that reduces relapse and slows brain atrophy in multiple sclerosis (MS) patients. In addition, FTY has been shown to enhance remyelination in certain animal models. OBJECTIVE: To analyze feasibility of a novel q-space Myelin Map imaging to monitor demyelination and remyelination under FTY treatment in MS patients. METHODS: Treatment outcomes of 24 consecutive MS patients treated with FTY were analyzed...
January 5, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28088312/dementia-in-parkinson-s-disease
#3
REVIEW
Hasmet A Hanagasi, Zeynep Tufekcioglu, Murat Emre
Dementia can occur in a substantial number of patients with Parkinson's disease with a point prevalence close to 30%. The cognitive profile is characterized by predominant deficits in executive, visuospatial functions, attention and memory. Behavioral symptoms are frequent such as apathy, visual hallucinations and delusions. The most prominent associated pathology is Lewy body-type and biochemical deficit is cholinergic. Placebo-controlled randomized trials with cholinesterase inhibitors demonstrated modest but significant benefits in cognition, behavioral symptoms and global functions...
January 5, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087060/personality-in-parkinson-s-disease-clinical-behavioural-and-cognitive-correlates
#4
REVIEW
Gabriella Santangelo, Fausta Piscopo, Paolo Barone, Carmine Vitale
Affective disorders and personality changes have long been considered pre-motor aspects of Parkinson's disease (PD). Many authors have used the term "premorbid personality" to define distinctive features of PD patients' personality characterized by reduced exploration of new environmental stimuli or potential reward sources ("novelty seeking") and avoidance behaviour ("harm avoidance") present before motor features. The functional correlates underlying the personality changes described in PD, implicate dysfunction of meso-cortico-limbic and striatal circuits...
January 5, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28094009/q-space-myelin-map-imaging-a-new-imaging-technique-for-treatment-evaluation-in-multiple-sclerosis
#5
Jun-Ichi Kira
No abstract text is available yet for this article.
January 4, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087061/editorial-and-introduction-behavioral-aspects-of-parkinson-s-disease
#6
EDITORIAL
Joseph H Friedman, Roongroj Bhidayasiri, Daniel D Truong
No abstract text is available yet for this article.
January 4, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28073433/misperceptions-and-parkinson-s-disease
#7
REVIEW
Joseph H Friedman
Most of the neurobehavioral aspects of Parkinson's disease have been well established and studied, but many are not well known, and hardly studied. This article focuses on several behavioral abnormalities that are common, and frequently cause difficulty for the patient and family due to lack of recognition as part of the disease. While it is well known that L-Dopa dyskinesias are frequently not recognized or under appreciated by patients, a similar lack of recognition may affect the patient's own speech volume, where their center of gravity is located, whether they are tilted to one side, and their under-recognition of others' emotional displays...
January 4, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28089250/pathology-of-behavior-in-pd-what-is-known-and-what-is-not
#8
REVIEW
Kaylena A Ehgoetz Martens, Simon J G Lewis
Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia...
December 29, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087059/fatigue-in-parkinson-s-disease
#9
REVIEW
Karen Herlofson, Benzi M Kluger
Fatigue is one of the most common nonmotor symptoms in Parkinson's disease and may affect a wide range of everyday activities, cause disability and reduce quality of life. It occurs at every stage of PD, and once present will often persist and may worsen over time. Lack of a consensus of definition and classification, and a range of different self-reporting scales has so far made the study of fatigue challenging. We review a unifying taxonomy for defining fatigue in clinical and research contexts as well as case definition criteria for PD-related fatigue...
December 29, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28011076/revised-set-of-diagnostic-criteria-for-neurocysticercosis-in-reply-to-garg-and-malhotra
#10
LETTER
O H Del Brutto, T E Nash, A C White, V Rajshekhar, P P Wilkins, G Singh, C M Vasquez, P Salgado, R H Gilman, H H Garcia
No abstract text is available yet for this article.
December 14, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28007418/a-new-and-revised-diagnostic-criterion-for-neurocysticercosis-issues-about-diagnosis-are-still-unresolved
#11
LETTER
Ravindra Kumar Garg, Hardeep Singh Malhotra
No abstract text is available yet for this article.
December 13, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27988032/neuroacanthocytosis-a-case-with-unusual-clinical-features-novel-response-to-treatment
#12
LETTER
Connie K Wu, Veronica E Santini, Christopher Dittus, Marie H Saint Hilaire
No abstract text is available yet for this article.
December 7, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27955933/response-to-neuroacanthocytosis-a-case-with-unusual-clinical-features-and-novel-response-to-treatment-by-wu-et-al
#13
LETTER
Ruth H Walker, Adrian Danek
No abstract text is available yet for this article.
December 5, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017257/autosomal-recessive-cerebellar-ataxia-type-1-mimicking-multiple-sclerosis-a-report-of-two-siblings-with-a-novel-mutation-in-syne1-gene-in-a-saudi-family
#14
Hussein Algahtani, Yousef Marzouk, Raghad Algahtani, Sali Salman, Bader Shirah
Autosomal Recessive Cerebellar Ataxia type 1 (ARCA1), also known as recessive ataxia of Beauce, is an adult onset pure cerebellar ataxia that typically presents with cerebellar ataxia and/or dysarthria. A mutation in the synaptic nuclear envelope protein 1 (SYNE1) gene that is located on chromosome 6p25 results in premature termination of the protein. It was first reported in 2007 as the first identified gene responsible for a recessively inherited pure cerebellar ataxia. In this article, we are presenting two brothers with ARCA1 who were misdiagnosed and treated as multiple sclerosis for more than a decade...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017256/treatment-of-neuromyelitis-optica-and-neuromyelitis-optica-spectrum-disorders-with-rituximab-using-a-maintenance-treatment-regimen-and-close-cd19-b-cell-monitoring-a-six-year-follow-up
#15
M E Evangelopoulos, E Andreadou, G Koutsis, V Koutoulidis, M Anagnostouli, P Katsika, D S Evangelopoulos, I Evdokimidis, C Kilidireas
Neuromyelitis optinca (NMO) represents a serious demyelinating disease of the central nervous system selectively attacking the spinal cord and optic nerve. Early differential diagnosis from multiple sclerosis is of vital importance, as NMO mandates immunosuppressive and not immunomodulatory treatment. Rituximab has been recently introduced as a treatment option for NMO. However, optimal surrogate measures and treatment intervals are still unclear. Five patients (females, mean age 54±10.21years) with NMO and NMO spectrum disorders (NMOSD) were evaluated with respect to disability and relapse rate...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017255/cognitive-deficits-in-non-demented-diabetic-elderly-appear-independent-of-brain-amyloidosis
#16
Gloria C Chiang, Eileen Chang, Sneha Pandya, Amy Kuceyeski, James Hu, Richard Isaacson, Christine Ganzer, Aaron Schulman, Vivian Sobel, Shankar Vallabhajosula, Lisa Ravdin
BACKGROUND: To determine the effects of Type 2 diabetes (DM2) on levels of brain amyloidosis and cognition in a community-dwelling cohort of nondemented elderly individuals. METHODS: 33 subjects (16 DM2, 17 nondiabetic) were prospectively recruited. Subjects underwent a PET scan using the amyloid tracer, Pittsburgh Compound B, and a neuropsychological evaluation. Associations between DM2, brain amyloidosis, and cognition were assessed using multivariate regressions, adjusting for age and APOE4 status...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017254/role-of-vitamin-a-metabolism-in-iih-results-from-the-idiopathic-intracranial-hypertension-treatment-trial
#17
J Libien, M J Kupersmith, W Blaner, M P McDermott, S Gao, Y Liu, J Corbett, M Wall
INTRODUCTION: Vitamin A and its metabolites (called retinoids) have been thought to play a role in the development of idiopathic intracranial hypertension (IIH). The IIH Treatment Trial (IIHTT) showed the efficacy of acetazolamide (ACZ) in improving visual field function, papilledema grade, quality of life and cerebrospinal fluid (CSF) pressure. We postulated that IIH patients would demonstrate elevated measures of vitamin A metabolites in the serum and CSF. METHODS: Comprehensive measures of serum vitamin A and its metabolites were obtained from 96 IIHTT subjects, randomly assigned to treatment with ACZ or placebo, and 25 controls with similar gender, age and body mass index (BMI)...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017253/therapeutic-route-of-patients-at-the-acute-phase-of-their-stroke-in-burkina-faso
#18
Christian Napon, Anselme Dabilgou, Julie Kyelem, Papougnézambo Bonkoungou, Jean Kaboré
INTRODUCTION: The advent of the neurovascular units and thrombolysis has improved support for stroke in developed countries. Our objective was to study the therapeutic route of stroke patients in Burkina Faso, a country with limited resources. METHODS: It was a prospective cohort study over a period of 4months, from February 02, 2014 to June 05, 2014, in medical emergencies and Neurology department of the teaching hospital Yalgado Ouedraogo. The study focused on patients diagnosed with stroke through brain imaging when they first entered hospital or during hospitalization...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017252/microcephaly-and-arthrogryposis-multiplex-congenita-the-full-blown-cns-spectrum-in-newborns-with-zikv-infection
#19
Marcio Leyser, Alexandre Fernandes, Pamela Passos, Camila Pupe, Andre Pc Matta, Marcio Moacyr Vasconcelos, Osvaldo Jm Nascimento
The recent alarming statements concerning the newborn ZIKV-induced microcephaly epidemics in the Northeast of Brazil, released by the Brazilian Ministry of Health, as well as important international health agencies, such as the World Health Organization and the Pan American Health Organization, raised many "why and how" questions so far, that will hopefully be scientifically answered, as more researches in that regard come up in the long term. In this paper, we describe another potentially ZIKV-induced central nervous system and musculoskeletal disorder that has accompanied microcephaly in these children: atrhogryposis multiplex congenita...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28017251/a-slc20a2-mutation-identified-in-an-asymptomatic-patient-with-brain-calcification
#20
LETTER
Monica Gagliardi, Maurizio Morelli, Grazia Iannello, Carmela Colica, Grazia Annesi, Aldo Quattrone
No abstract text is available yet for this article.
January 15, 2017: Journal of the Neurological Sciences
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