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Journal of the Neurological Sciences

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https://www.readbyqxmd.com/read/29153510/resumption-of-antiplatelet-therapy-in-patients-with-primary-intracranial-hemorrhage-benefits-and-risks-a-meta-analysis-of-cohort-studies
#1
REVIEW
Xueying Ding, Xi Liu, Changhong Tan, Maojia Yin, Teng Wang, Ying Liu, Lijuan Mo, Xin Wei, Xinjie Tan, Fen Deng, Lifen Chen
BACKGROUND: Clinical disagreement over antiplatelet (AP) resumption in patients with primary intracranial hemorrhage (ICH) has long existed. This meta-analysis aimed to evaluate the benefits of AP resumption on preventing ischemic or thromboembolic events against its risks of promoting ICH recurrence or hematoma expansion. METHODS: All relevant articles published in Pubmed, EMBASE, the Cochrane Library, and Science Direct from January 1950 to March 2017 were sourced, and the combined relative risk (RR) was calculated...
November 10, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29122295/a-case-of-neuromyelitis-optica-spectrum-disorder-presenting-with-undiagnosed-sjogren-s-syndrome-and-a-single-atypical-tumefactive-lesion-a-clinical-conundrum
#2
LETTER
Alexander B Ramos, Cacey W Peters, Bernard Landry-Wegener, Louis A Cannizzaro, Jesús Lovera
No abstract text is available yet for this article.
November 6, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29122296/a-case-of-neuromyelitis-optica-spectrum-disorder-presenting-with-undiagnosed-sjogren-s-syndrome-and-a-single-atypical-tumefactive-lesion-a-diagnostic-challenge
#3
EDITORIAL
Jeanie C McGee, Alireza Minagar
No abstract text is available yet for this article.
November 1, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29108750/new-spectrum-of-the-neurologic-consequences-of-zika
#4
EDITORIAL
Marco T Medina, Marco Medina-Montoya
Zika virus infection represents a new neuropathological agent with association to a wide spectrum of neurological complications: a) Congenital Zika Syndrome by affecting the neural stem cells of the human fetal brain; b) Guillain-Barré Syndrome by an autoimmune response against peripheral myelin and/or axonal components or probable direct inflammatory reaction; c) Encephalitis/meningoencephalitis and myelitis by a direct viral inflammatory process on the central nervous system; d) Sensory neuropathy by infecting directly the peripheral neurons and causing substantial cell death and pathogenic transcriptional dysregulation; e) Acute Disseminated Encephalomyelitis and optic neuropathy; f) Seizures and Epilepsy and g) childhood arterial ischemic stroke by probable inflammatory reaction and endothelial injury...
November 1, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29122294/zika-vasculitis-a-new-cause-of-stroke-in-children
#5
LETTER
Anne Landais, Audrey Césaire, Manuel Fernandez, Sébastien Breurec, Cécile Herrmann, Fréderique Delion, Philippe Desprez
Viral infectious vasculitis is a cause of stroke in children. Zika virus infection is often asymptomatic. Neurological complications have however been reported: Guillain-Barré, ADEM, meningoencephalitis, myelitis, microcephaly in the fetus of infected mothers. We discuss the case of a child presenting acute infection with ZIKV that was associated with a stroke. A 10-months-old boy without medical history presented after 2days of fever and cutaneous rash, conjunctivitis on day 5, a right hemiparesis on day 6...
October 27, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29146095/a-two-year-study-using-cerebral-gray-matter-volume-to-assess-the-response-to-fingolimod-therapy-in-multiple-sclerosis
#6
Fawad Yousuf, Sheena L Dupuy, Shahamat Tauhid, Renxin Chu, Gloria Kim, Subhash Tummala, Fariha Khalid, Howard L Weiner, Tanuja Chitnis, Brian C Healy, Rohit Bakshi
BACKGROUND: Cerebral gray matter (GM) atrophy has clinical relevance in multiple sclerosis (MS). Fingolimod has known efficacy on clinical and conventional MRI findings in MS; the effect on GM is unknown. OBJECTIVE: To explore fingolimod's treatment effect on cerebral GM atrophy over two years in patients with relapsing forms of MS. DESIGN/METHODS: Patients starting fingolimod [n=24, age (mean±SD) 41.2±11.6years, Expanded Disability Status Scale (EDSS) score 1...
October 16, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29102163/assessing-the-cerebral-gray-matter-volume-in-response-to-fingolimod-therapy-in-multiple-sclerosis-a-more-analytic-view
#7
EDITORIAL
Jeanie C McGee, Alireza Minagar
No abstract text is available yet for this article.
October 13, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29066135/need-for-refining-successful-revascularization-in-endovascular-treatment-of-acute-ischemic-stroke-data-from-real-world
#8
Andreia Carvalho, Telma Santos, André Cunha, Tiago Gregório, Ludovina Paredes, Henrique Costa, Sérgio Castro, Manuel Ribeiro, Miguel Veloso, Pedro Barros
INTRODUCTION: Modified TICI (mTICI) score≥2b has been largely used as a definition of successful revascularization in acute stroke endovascular treatment (EVT). However, mTICI 2b encompasses a broad range of different revascularization states and its clinical relevance, comparing to mTICI 3, has been questioned. We aimed to compare clinical outcomes between these two reperfusion groups, in patients submitted to EVT for anterior circulation large-vessel occlusion, in a real-world setting...
October 13, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29046221/botulinum-toxin-after-stroke-a-functional-point-of-view
#9
LETTER
Matteo Paci
No abstract text is available yet for this article.
October 10, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29042064/botulinum-toxin-therapy-as-an-early-intervention-for-post-stroke-spasticity-beyond-a-functional-viewpoint
#10
LETTER
Raymond Rosales
No abstract text is available yet for this article.
October 10, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29055498/carotid-artery-stenosis-as-an-independent-risk-factor-for-perioperative-strokes-following-mitral-valve-surgical-intervention
#11
Reshmi Udesh, Pawan Solanki, Amol Mehta, Thomas Gleason, Lawrence Wechsler, Parthasarathy D Thirumala
OBJECTIVE: To examine the role of carotid stenosis (CS) and other independent risk factors of perioperative stroke following either mitral valve repair or replacement. METHODS: Using data from the National Inpatient Sample (NIS) database for analysis, all patients who underwent either mitral valve repair or replacement were identified using ICD-9 codes. RESULTS: A total of 79,583 patients who underwent either mitral valve replacement or repair were studied...
October 6, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29032280/carotid-artery-stenosis-and-peri-operative-stroke-in-cardiac-surgery-a-bridge-between-heart-and-brain
#12
EDITORIAL
Simona Lattanzi, Mauro Silvestrini
No abstract text is available yet for this article.
October 6, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28992946/author-reply-mtdna-m-3472t-c-could-be-classified-as-a-primary-mutation-of-leber-s-hereditary-optic-neuropathy
#13
LETTER
Moon-Woo Seong, Jongmoon Choi, Sung Sup Park, Ji Yeon Kim, Jeong-Min Hwang
No abstract text is available yet for this article.
September 30, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28992945/pathogenicity-of-the-lhon-variant-m-3472t-c-is-uncertain
#14
LETTER
Josef Finsterer, Sinda Zarrouk-Mahjoub
No abstract text is available yet for this article.
September 30, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28992944/response-by-sarfo-and-ovbiagele-to-letter-regarding-potential-role-of-tele-rehabilitation-to-address-barriers-to-implementation-of-physical-therapy-among-west-african-stroke-survivors-a-cross-sectional-survey
#15
LETTER
https://www.readbyqxmd.com/read/28965998/comments-on-potential-role-of-tele-rehabilitation-to-address-barriers-to-implementation-of-physical-therapy-among-west-african-stroke-survivors-a-cross-sectional-survey
#16
LETTER
Erfan Ayubi, Saeid Safiri
No abstract text is available yet for this article.
September 27, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29111029/hematoma-volume-is-a-predictive-factor-of-disturbed-autoregulation-after-spontaneous-intracerebral-hemorrhage
#17
Hongyin Ma, Zhen-Ni Guo, Xin Sun, Jia Liu, Shan Lv, Lu Zhao, Weitong Guo, Hang Jin, Yi Yang
BACKGROUND: Dynamic cerebral autoregulation (dCA) is probably disturbed after spontaneous intracerebral hemorrhage (ICH) and could be an independent predictor of clinical outcome. Clinical determinants of dCA status after ICH need to be further elucidated. METHODS: We finally enrolled 53 patients diagnosed with supratentorial ICH within 6days from onset. DCA was assessed 4-6days after ICH onset by monitoring middle cerebral artery blood flow velocities and simultaneous arterial blood pressure continuously, utilizing transcranial Doppler combined with a servo-controlled finger plethysmograph...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29111028/csf-biomarkers-%C3%AE-amyloid-tau-proteins-and-a-synuclein-in-the-differential-diagnosis-of-parkinson-plus-syndromes
#18
Vasilios C Constantinides, George P Paraskevas, Evangelia Emmanouilidou, Olga Petropoulou, Anastasia Bougea, Kostas Vekrellis, Ioannis Evdokimidis, Eleftherios Stamboulis, Elisabeth Kapaki
INTRODUCTION: Differential diagnosis of Parkinson-plus patients (PSP, CBD, MSA) and Parkinson's disease (PD) patients is often not straightforward, particularly in atypical cases or at the initial stages of the diseases. Classic CSF biomarkers (amyloid-beta - Aβ42, tau protein - τT and phosphorylated tau protein - τP-181) are established biomarkers in the diagnosis of Alzheimer's disease (AD). CSF a-synuclein (α-syn) has emerged as a promising biomarker in patients with Parkinsonism...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29111027/sequence-configuration-of-spinocerebellar-ataxia-type-8-repeat-expansions-in-a-japanese-cohort-of-797-ataxia-subjects
#19
Yajun Hu, Yuji Hashimoto, Takashi Ishii, Mamut Rayle, Kazumasa Soga, Nozomu Sato, Michi Okita, Miwa Higashi, Kokoro Ozaki, Hidehiro Mizusawa, Kinya Ishikawa, Takanori Yokota
Spinocerebellar ataxia type 8 (SCA8), an autosomal dominant neurodegenerative disorder showing slowly progressive cerebellar ataxia, is caused by a tri-nucleotide CTG repeat expansion (CTGexp) in the SCA8 gene. As the CTGexp is not fully penetrant, the significance of screening CTGexp in ataxia subjects remains obscure. We tested SCA8 CTGexp in a cohort of 797 ataxia subjects, and if present, its sequence configuration was analyzed. CTGexp was found in 16 alleles from 14 individuals, 2 of which was homozygous for CTGexp...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29111026/a-retrospective-study-of-acetylcholine-receptor-antibody-positive-ocular-myasthenia-in-the-west-of-scotland
#20
Maria E Farrugia, Marie Cleary, Caroline Carmichael
Ocular myasthenia is the milder end of the myasthenia gravis spectrum but treatment can be challenging especially in older patients. We retrospectively studied all patients on our database with ocular myasthenia (OMG), positive for acetylcholine receptor (AChR) antibodies. We identified 93 patients (64 men and 29 women). The mean age at disease onset was 63y, median 68y. Most (72%) experienced ptosis with diplopia; 19% experienced ptosis alone, while 7.5% complained of diplopia without ptosis. As expected, pyridostigmine was commenced early at diagnosis in the majority (69%) and 20% were still receiving pyridostigmine at final review...
November 15, 2017: Journal of the Neurological Sciences
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