journal
MENU ▼
Read by QxMD icon Read
search

Journal of Endocrinology

journal
https://www.readbyqxmd.com/read/29142025/cardioprotection-of-dapagliflozin-and-vildagliptin-in-cardiac-reperfusion-injury-rats
#1
Pongpan Tanajak, Piangkwan Sa-Nguanmoo, Sivaporn Sivasinprasan, Savitree Thummasorn, Natthaphat Siri-Angkul, Siriporn Chattipakorn, Nipon Chattipakorn
Sodium-glucose cotransporter 2 inhibitor (SGLT2-i) effects on cardiac ischemia/reperfusion (I/R) injury are unclear. Unlike SGLT2-i, dipeptidyl peptidase 4 inhibitors (DPP4-i) have shown effective cardioprotection in cardiac I/R injury. We aimed to investigate whether SGLT2-i reduces myocardial dysfunction and myocardial injury to a greater extent than DPP4-i in obese-insulin resistant rats with/without cardiac I/R injury. The high fat (HF) diet induced obese-insulin resistant rats were divided into 4 groups and received the following treatments for 28 days: vehicle (HFV); vildagliptin at a dosage of 3 mg/kg/day (HFVil); dapagliflozin at a dosage of 1 mg/kg/day (HFDa); and combination drugs (HFDaVil)...
November 15, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29114012/cbl-downregulation-increases-rbp4-expression-in-adipocytes-of-female-mice
#2
Gulizar Issa Ameen, Silvia Mora
Obesity leads to adipose tissue dysfunction, insulin resistance and diabetes. Adipose tissue produces adipokines,that contribute to regulate insulin sensitivity. In turn insulin stimulates the production and release of some adipokines. Casitas-b-lymphoma proteins (c-Cbl, Cbl-b and Cbl3) are intracellular adaptor signalling proteins that are rapidly phosphorylated by activation of tyrosine kinase receptors. c-Cbl is rapidly phosphorylated by insulin in adipocytes. Here we tested the hypothesis that Cbl signalling regulates adipokine expression in adipose tissue...
November 7, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29109081/vitamin-d-the-placenta-and-early-pregnancy-effects-on-trophoblast-function
#3
Ankana Ganguly, Jennifer Ann Tamblyn, Sarah Finn-Sell, Shiao-Yng Chan, Melissa Westwood, Janesh Gupta, Mark Kilby, Stephane R Gross, Martin Hewison
Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH)2D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH)2D remains unclear, but is likely to involve localised tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH)2D...
November 6, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29109080/central-leptin-regulates-heart-lipid-content-by-selectively-increasing-ppar-%C3%AE-%C3%AE-expression
#4
Cristina Mora, Cristina Pintado, Blanca Rubio, Lorena Mazuecos, Virginia Lopez, Alejandro Fernandez, Aurora Salamanca, Brenda Barcena, Teresa Fernandez-Agullo, Carmen Arribas, Nilda Gallardo, Antonio Andres
The role of central leptin in regulating the heart from lipid accumulation in lean leptin-sensitive animals has not been fully elucidated. Herein we investigated the effects of central leptin infusion on the expression of genes involved in cardiac metabolism and its role in the control of myocardial triacylglyceride (TAG) accumulation in adult Wistar rats. Intracerebroventricular (icv) leptin infusion (0.2µg/day) for 7 days markedly decreased TAG levels in cardiac tissue. Remarkably, the cardiac anti-steatotic effects of central leptin were associated with the selective up-regulation of gene and protein expression of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) and their target genes, adipose triglyceride lipase (ATGL), hormone sensitive lipase (HSL), pyruvate dehydrogenase kinase 4 (PDK4), and acyl CoA oxidase 1 (Acox1), involved in myocardial intracellular lipolysis and mitochondrial/peroxisomal fatty acid utilization...
November 6, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29051192/animal-models-to-explore-the-effects-of-glucocorticoids-on-skeletal-growth-and-structure
#5
Claire L Wood, Ondrej Soucek, Jarod Wong, Farasat Zaman, Colin Farquharson, Lars Savendahl, S Faisal Ahmed
Glucocorticoids (GCs) are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, important and a well characterized pre-clinical model is vital for the evaluation of new interventions...
October 19, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29051191/role-of-thyroid-hormone-in-skeletal-muscle-physiology
#6
Flavia F Bloise, Aline Cordeiro, Tania Maria Ortiga-Carvalho
Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic metabolism are influenced by TH. These effects depend on the presence of the TH transporters MCT8 and MCT10 in the plasma membrane, the expression of TH receptors (THRA or THRB) and hormone availability, which is determined either by the activation of thyroxine (T4) into triiodothyronine (T3) by type 2 iodothyronine deiodinases (D2) or by the inactivation of T4 into reverse T3 by deiodinases type 3 (D3)...
October 19, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29046340/nnt-is-a-key-regulator-of-adrenal-redox-homeostasis-and-steroidogenesis-in-male-mice
#7
Eirini Meimaridou, Michelle Goldsworthy, Vasileios Chortis, Ersi Fragouli, Paul A Foster, Wiebke Arlt, Roger Cox, Louise A Metherell
Nicotinamide nucleotide transhydrogenase, NNT, is a ubiquitous protein of the inner mitochondrial membrane with a key role in mitochondrial redox balance. NNT produces high concentrations of NADPH for detoxification of reactive oxygen species by glutathione and thioredoxin pathways. In humans, NNT dysfunction leads to an adrenal specific disorder, glucocorticoid deficiency. Certain sub-strains of C57BL/6 mice contain a spontaneously occurring inactivating Nnt mutation and display glucocorticoid deficiency along with glucose intolerance and reduced insulin secretion...
October 18, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28993437/thyroid-hormone-regulates-protease-expression-and-activation-of-notch-signaling-in-implantation
#8
Diletta Piccirilli, Enke Baldini, Micol Massimiani, Antonella Camaioni, Antonietta Salustri, Roberta Bernardini, Marco Centanni, Salvatore Ulisse, Constanzo Moretti, Luisa Campagnolo
A clinical association between thyroid dysfunction and pregnancy complications has been extensively reported, however the molecular mechanisms through which TH might regulate key-events of pregnancy have not been elucidated yet. In this respect, we performed in vivo studies in MMI- induced hypothyroid pregnant mice, evaluating the effect of hypothyroidism on the number of implantation sites, developing embryos/resorptions and pups per litter, at 4.5, 10.5, 18.5 days post coitum (dpc) and at birth. We also studied the expression of major molecules involved in implantation and placentation, such as the proteases ISPs, MMPs, TIMPs and Notch pathway related genes...
October 9, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28870888/cell-secreted-vesicles-containing-micrornas-as-regulators-of-gamete-maturation
#9
Juliano C da Silveira, Ana Clara F C M de Avila, Hannah L Garrett, Jason Bruemmer, Quinton Winger, Gerrit Bouma
Mammalian gamete maturation requires extensive signaling between germ cells and their surrounding somatic cells. In the ovary, theca cells, mural granulosa cells, cumulus cells and the oocyte all secrete factors throughout follicle growth and maturation that are critical for ovulation of a high quality oocyte with the competence to develop into an embryo. Similarly, maturation of sperm occurs as it transits the epididymis during which epididymal epithelium and sperm exchange secretory factors that are required for sperm to gain motility and fertility...
September 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28855317/novel-skeletal-effects-of-glucagon-like-peptide-1-glp-1-receptor-agonists
#10
Guillaume Mabilleau, Marie Pereira, Chantal Chenu
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications. In addition, some anti-diabetic therapies for T2DM can have notable detrimental skeletal effects. Thus an appropriate therapeutic strategy for T2DM should not only be effective in re-establishing good glycaemic control but also in minimising skeletal complications. There is increasing evidence that Glucagon-like peptide-1 receptor (GLP-1r) agonists, now greatly prescribed for the treatment of T2DM, have beneficial skeletal effects although the underlying mechanisms are not completely understood...
August 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28855316/stem-progenitor-cells-in-pituitary-organ-homeostasis-and-tumorigenesis
#11
Scott Haston, Saba Manshaei, Juan Pedro Martinez-Barbera
Evidence for the presence of pituitary gland stem cells has been provided over the last decade using a combination of approaches including in vitro clonogenicity assays, flow cytometric side population analysis, immunohistochemical analysis and genetic approaches. These cells have been demonstrated to be able to self-renew and undergo multipotent differentiation to give rise to all hormonal lineages of the anterior pituitary. Furthermore, evidence exists for their contribution to regeneration of the organ and plastic responses to changing physiological demand...
August 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29042402/ginsenoside-rg3-ameliorated-hfd-induced-hepatic-steatosis-through-downregulation-of-stat5-ppar%C3%AE
#12
Jin-Bong Lee, Sung-Jin Yoon, Sang-Hyun Lee, Moo-Seung Lee, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Inpyo Choi, Ik-Soo Kim, Su Wol Chung, Hee Gu Lee, Jeong-Ki Min, Young-Jun Park
Healthy expansion of adipose tissue maintains metabolic homeostasis by storing excess chemical energy in increased fat mass. The STAT5-PPAR gamma pathway reportedly regulates adipocyte differentiation, lipid metabolism and adipogenesis. Ginsenoside Rg3 is one of the diverse groups of steroidal saponins, the major active components of ginseng, which have demonstrated pharmacological properties. In this study, we evaluated the therapeutic effects of ginsenoside Rg3 under pathological conditions in vitro and in vivo We examined the effects of ginsenoside Rg3 on glucose level, insulin sensitivity and lipogenesis in high-fat diet-fed C57BL/6 mice...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28970286/obesity-stimulated-aldosterone-release-is-not-related-to-an-s1p-dependent-mechanism
#13
Stephan Werth, Helge Müller-Fielitz, Walter Raasch
Aldosterone has been identified as an important factor in obesity-associated hypertension. Here, we investigated whether sphingosine-1-phosphate (S1P), which has previously been linked to obesity, increases aldosterone release. S1P-induced aldosterone release was determined in NCI H295R cells in the presence of S1P receptor (S1PR) antagonists. In vivo release of S1P (100-300 µg/kgbw) was investigated in pithed, lean Sprague Dawley (SD) rats, diet-obese spontaneous hypertensive rats (SHRs), as well as in lean or obese Zucker rats...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28931557/protective-effect-of-cyanidin-3-o-glucoside-on-neonatal-porcine-islets
#14
Chao Li, Bin Yang, Zhihao Xu, Eric Boivin, Mazzen Black, Wenlong Huang, Baoyou Xu, Ping Wu, Bo Zhang, Xian Li, Kunsong Chen, Yulian Wu, Gina R Rayat
Oxidative stress is a major cause of islet injury and dysfunction during isolation and transplantation procedures. Cyanidin-3-O-glucoside (C3G), which is present in various fruits and vegetables especially in Chinese bayberry, shows a potent antioxidant property. In this study, we determined whether C3G could protect neonatal porcine islets (NPI) from reactive oxygen species (H2O2)-induced injury in vitro and promote the function of NPI in diabetic mice. We found that C3G had no deleterious effect on NPI and that C3G protected NPI from damage induced by H2O2 Significantly higher hemeoxygenase-1 (HO1) gene expression was detected in C3G-treated NPI compared to untreated islets before and after transplantation (P < 0...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28899903/socs3-expression-in-sf1-cells-regulates-adrenal-differentiation-and-exercise-performance
#15
João A B Pedroso, Pedro O R de Mendonca, Marco A S Fortes, Igor Tomaz, Vitor L Pecorali, Thais B Auricino, Ismael C Costa, Leandro B Lima, Isadora C Furigo, Debora N Bueno, Angela M Ramos-Lobo, Claudimara F P Lotfi, Jose Donato
Many hormones/cytokines are secreted in response to exercise and cytokine signaling may play a pivotal role in the training adaptations. To investigate the importance of cytokine signaling during vertical ladder climbing, a resistance exercise model, we produced mice lacking SOCS3 protein exclusively in steroidogenic factor-1 (SF1) cells (SF1 Socs3 KO mice). SF1 expression is found in steroidogenic cells of the adrenal cortex and gonads, as well as in neurons of the ventromedial nucleus of the hypothalamus...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28870887/appetite-food-intake-and-gut-hormone-responses-to-intense-aerobic-exercise-of-different-duration
#16
RANDOMIZED CONTROLLED TRIAL
Adrian Holliday, Andrew Blannin
The purpose of the study is to investigate the effect of acute bouts of high-intensity aerobic exercise of differing durations on subjective appetite, food intake and appetite-associated hormones in endurance-trained males. Twelve endurance-trained males (age = 21 ± 2 years; BMI = 21.0 ± 1.6 kg/m(2); VO2max = 61.6 ± 6.0 mL/kg/min) completed four trials, within a maximum 28 day period, in a counterbalanced order: resting (REST); 15 min exercise bout (15-min); 30 min exercise bout (30-min) and 45 min exercise bout (45-min)...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28855315/eplerenone-prevented-obesity-induced-inflammasome-activation-and-glucose-intolerance
#17
Tsutomu Wada, Akari Ishikawa, Eri Watanabe, Yuto Nakamura, Yusuke Aruga, Hayate Hasegawa, Yasuhiro Onogi, Hiroe Honda, Yoshinori Nagai, Kiyoshi Takatsu, Yoko Ishii, Masakiyo Sasahara, Daisuke Koya, Hiroshi Tsuneki, Toshiyasu Sasaoka
Obesity-associated activation of the renin-angiotensin-aldosterone system is implicated in the pathogenesis of insulin resistance; however, influences of mineralocorticoid receptor (MR) inhibition remain unclear. Therefore, we aimed to clarify the anti-inflammatory mechanisms of MR inhibition using eplerenone, a selective MR antagonist, in C57BL/6 mice fed a high-fat diet (HFD) for 12 weeks. Eplerenone prevented excessive body weight gain and fat accumulation, ameliorated glucose intolerance and insulin resistance and enhanced energy metabolism...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28851750/food-in-synchrony-with-melatonin-and-corticosterone-relieves-constant-light-disturbed-metabolism
#18
Adrián Báez-Ruiz, Natalí N Guerrero-Vargas, Fernando Cázarez-Márquez, Elizabeth Sabath, María Del Carmen Basualdo, Roberto Salgado-Delgado, Carolina Escobar, Ruud M Buijs
Circadian disruption is associated with metabolic disturbances such as hepatic steatosis (HS), obesity and type 2 diabetes. We hypothesized that HS, resulting from constant light (LL) exposure is due to an inconsistency between signals related to food intake and endocrine-driven suprachiasmatic nucleus (SCN) outputs. Indeed, exposing rats to LL induced locomotor, food intake and hormone arrhythmicity together with the development of HS. We investigated whether providing temporal signals such as 12-h food availability or driving a corticosterone plus melatonin rhythm could restore rhythmicity and prevent the metabolic disturbances under LL conditions in male rats...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28835453/aip-and-the-somatostatin-system-in-pituitary-tumours
#19
REVIEW
Alejandro Ibáñez-Costa, Márta Korbonits
Classic somatostatin analogues aimed at somatostatin receptor type 2, such as octreotide and lanreotide, represent the mainstay of medical treatment for acromegaly. These agents have the potential to decrease hormone secretion and reduce tumour size. Patients with a germline mutation in the aryl hydrocarbon receptor-interacting protein gene, AIP, develop young-onset acromegaly, poorly responsive to pharmacological therapy. In this review, we summarise the most recent studies on AIP-related pituitary adenomas, paying special attention to the causes of somatostatin resistance; the somatostatin receptor profile including type 2, type 5 and truncated variants; the role of G proteins in this pathology; the use of first and second generation somatostatin analogues; and the role of ZAC1, a zinc-finger protein with expression linked to AIP in somatotrophinoma models and acting as a key mediator of octreotide response...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28814440/mechanical-hormonal-and-metabolic-influences-on-blood-vessels-blood-flow-and-bone
#20
REVIEW
Rhonda D Prisby
Bone tissue is highly vascularized due to the various roles bone blood vessels play in bone and bone marrow function. For example, the vascular system is critical for bone development, maintenance and repair and provides O2, nutrients, waste elimination, systemic hormones and precursor cells for bone remodeling. Further, bone blood vessels serve as egress and ingress routes for blood and immune cells to and from the bone marrow. It is becoming increasingly clear that the vascular and skeletal systems are intimately linked in metabolic regulation and physiological and pathological processes...
December 2017: Journal of Endocrinology
journal
journal
23809
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"