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Journal of Endocrinology

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https://www.readbyqxmd.com/read/28428364/role-of-oestrogen-receptor-signaling-in-skeletal-response-to-leptin-in-female-ob-ob-mice
#1
Russell T Turner, Kenneth A Philbrick, Amida Kuah, Adam J Branscum, Urszula T Iwaniec
Leptin, critical in regulation of energy metabolism, is also important for normal bone growth, maturation and turnover. Compared to wild type (WT) mice, bone mass is lower in leptin-deficient ob/ob mice; osteopenia in growing ob/ob mice is due to decreased bone accrual, and is associated with reduced longitudinal bone growth, impaired cancellous bone maturation and increased marrow adipose tissue (MAT). However, leptin deficiency also results in gonadal dysfunction, disrupting production of gonadal hormones which regulate bone growth and turnover...
April 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28428363/phlpp-a-putative-cellular-target-during-insulin-resistance-and-type-2-diabetes
#2
Alpana Mathur, Vivek Kumar Pandey, Poonam Kakkar
Progressive research in the past decade converges to the impact of PHLPP (Pleckstrin homology domain and leucine rich repeat protein phosphatase) in regulating the cellular metabolism through PI3K/Akt inhibition. Defects in the PKB/Akt signaling coordinates with impaired insulin secretion and insulin resistance, identified during T2D, obesity and cardiovascular disorders which brings in the relevance of PHLPPs in the metabolic paradigm. In this review, we discuss the impact of PHLPP isoforms in insulin signaling and its associated cellular events including mitochondrial dysfunction, DNA damage, autophagy and cell death...
April 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28428362/hepatic-lipid-accumulation-cause-and-consequence-of-dysregulated-glucoregulatory-hormones
#3
Caroline E Geisler, Benjamin Jennings Renquist
Fatty liver can be diet, endocrine, genetic, viral, or drug induced. Independent of cause, hepatic lipid accumulation promotes systemic metabolic dysfunction. By acting as peroxisome proliferator activated receptor (PPAR) ligands, hepatic non-esterified fatty acids upregulate expression of gluconeogenic, beta-oxidative, lipogenic, and ketogenic genes, promoting hyperglycemia, hyperlipidemia, and ketosis. The typical hormonal environment in fatty liver disease consists of hyperinsulinemia, hyperglucagonemia, hypercortisolemia, growth hormone deficiency, and elevated sympathetic tone...
April 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28420709/thermal-imprinting-modifies-adult-stress-and-innate-immune-responsiveness-in-the-teleost-sea-bream
#4
Ana Patrícia Mateus, Rita Costa, João C R Cardoso, Karl B Andree, Alicia Estévez, Enric Gisbert, Deborah M Power
The impact of thermal imprinting during development on the plasticity of the hypothalamic-pituitary-interrenal (HPI) axis and stress response in an adult ectotherm, the gilthead sea bream (Sparus aurata, L.), was assessed. Fish were reared under 4 thermal regimes and the resulting adults exposed to acute confinement stress and plasma cortisol levels and genes of the HPI axis monitored. Changes in immune function, a common result of stress, was also evaluated using histomorphometric measurements of melano-macrophages centres (MMCs) in the head kidney and by monitoring macrophage related transcripts...
April 18, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28420708/activation-of-the-p2y2-receptor-regulates-bone-cell-function-by-enhancing-atp-release
#5
Isabel R Orriss, Dilek Gueneri, Mark Or Hajjawi, Kristy Shaw, Jessal J Patel, Tim R Arnett
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation the functional effects of this receptor in osteoclasts remain unknown. This investigation used the P2Y2 receptor knockout (P2Y2R(-/-) ) mouse model to investigate the role of this receptor in bone. MicroCT analysis of P2Y2R(-/-) mice demonstrated age-related increases in trabecular bone volume (≤48%), number (≤30%) and thickness (≤17%)...
April 18, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28420707/role-of-the-fatty-acid-binding-protein-4-in-heart-failure-and-cardiovascular-disease
#6
Ricardo Rodriguez-Calvo, Josefa Girona, Josep M Alegret, Alba Bosquet, Daiana Ibarretxe, Lluís Masana
Obesity and ectopic fat accumulation in non-adipose tissues are major contributors to heart failure (HF) and cardiovascular disease (CVD). Adipocytes act as endocrine organs by releasing a large number of bioactive molecules into the bloodstream, which participate in a communication network between white adipose tissue and other organs, including the heart. Among these molecules, fatty acid binding protein 4 (FABP4) has been recently shown to increase cardiometabolic risk. Both clinical and experimental evidence have identified FABP4 as a relevant player in atherosclerosis and coronary artery disease, and it has been directly related to cardiac alterations such as left ventricular hypertrophy (LVH) or both systolic and diastolic cardiac dysfunction...
April 18, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28400405/nutritional-approaches-for-managing-obesity-associated-metabolic-diseases
#7
Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li, Chaodong Wu
Obesity is an ongoing pandemic and serves as a causal factor of a wide spectrum of metabolic diseases including diabetes, fatty liver disease, and cardiovascular disease. Much evidence has demonstrated that nutrient overload initiates or exacerbates inflammatory responses in tissues/organs involved in the regulation of systemic metabolic homeostasis. This obesity-associated inflammation is usually at a low-grade and viewed as metabolic inflammation. When it exists continuously, inflammation inappropriately alters metabolic pathways and impairs insulin signaling cascades in peripheral tissues/organs such as adipose tissue, the liver and skeletal muscle, resulting in local fat deposition and insulin resistance and systemic metabolic dysregulation...
April 11, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28385724/on-gonads-and-gadflies-the-estrus-angle
#8
Stephen G Hillier
The first sex steroid to be crystallized was the vertebrate ovarian hormone, estrone - a less potent metabolite of 17βestradiol, which in mammals stimulates the female urge to mate (estrus). The gadfly (Greek oistros) lent its name to the process of estrus, as an insect that bites and torments in classical Greek mythology. With the crystallization of a moult-inducing steroid (ecdysone) from insects, an interesting parallel emerged between mating and moulting in mammals and arthropods. Ecdysterone (potent ecdysone metabolite) has anabolic effects in mammalian muscle cells that can be blocked by selective estrogen receptor-antagonists...
April 6, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28385723/fabp4-cre-mediated-sirt6-deletion-impairs-adipose-tissue-function-and-metabolic-homeostasis-in-mice
#9
Xiwen Xiong, Cuicui Zhang, Yang Zhang, Rui Fan, Xinlai Qian, Xiaocheng Charlie Dong
SIRT6 is a member of sirtuin family of deacetylases involved in diverse processes including genome stability, metabolic homeostasis, and anti-inflammation. However, its function in the adipose tissue is not well understood. To examine the metabolic function of SIRT6 in the adipose tissue, we generated two mouse models that are deficient in Sirt6 using the Cre-lox approach. Two commonly used Cre lines that are driven by either the mouse Fabp4 or Adipoq gene promoter were chosen for this study. The Sirt6 knockout mice generated by the Fabp4-Cre line (Sirt6f/f:Fabp4-Cre) had a significant increase in both body weight and fat mass, and exhibited glucose intolerance and insulin resistance as compared with the control wildtype mice...
April 6, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28381504/insulin-receptor-substrate-signaling-controls-cardiac-energy-metabolism-and-heart-failure
#10
Cathy A Guo, Shaodong Guo
The heart is an insulin-dependent and energy consuming organ in which insulin and nutritional signaling integrates to the regulation of cardiac metabolism, growth, and survival. Heart failure is highly associated with insulin resistance and heart failure patients suffer from the cardiac energy deficiency, structural and functional dysfunction. Chronic pathological conditions, such as obesity and type 2 diabetes mellitus, involve various mechanisms in promoting heart failure by remodeling metabolic pathways, modulating cardiac energetics, and impairing cardiac contractility...
April 5, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28377404/effect-of-androgen-on-kiss1-expression-and-luteinizing-hormone-release-in-female-rats
#11
Kinuyo Iwata, Yuyu Kunimura, Keisuke Matsumoto, Hitoshi Ozawa
Hyperandrogenic women have various grades of ovulatory dysfunction, which lead to infertility. The purpose of this study was to determine whether chronic exposure to androgen affects expression of kisspeptin (ovulation and follicle development regulator) or release of luteinizing hormone (LH) in female rats. Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age. Number of Kiss1-expressing cells in both the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) was significantly decreased in ovary-intact DHT rats...
April 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28360082/adipose-tissue-supports-normalization-of-macrophage-and-liver-lipid-handling-in-obesity-reversal
#12
Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pacht, Tanya Tarnovsky, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan, Assaf Rudich
Adipose tissue inflammation and dysfunction are considered central in the pathogenesis of obesity-related dys-metabolism, but their role in the rapid metabolic recovery upon obesity reversal is less well-defined. We hypothesized that changes in adipose tissue endocrine and paracrine mechanisms may support the rapid improvement of obesity-induced impairment in cellular lipid handling. C57Bl-6J mice were fed ad-libitum either normal chow (NC) or high-fat diet (HFF) for 10 weeks. A dietary obesity reversal group was fed HFF for 8 weeks, then switched to NC for 2 weeks (HFFNC)...
March 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28360081/resolution-of-glucose-intolerance-in-long-term-high-fat-high-sucrose-fed-mice
#13
Greg Kowalski, Michael Kraakman, Shaun Mason, Andrew Murphy, Clinton R Bruce
The high-fat, high-sucrose diet (HFSD) fed C57Bl/6 mouse is a widely used model of prediabetes. However, studies typically implement a relatively short dietary intervention lasting between 4-16 weeks, as a result little is known about how a long-term HFSD impacts the metabolic profile of these mice. Therefore, the aim of this investigation was to examine the effects of consuming a HFSD for 42 weeks on the development of hyperinsulinemia and glucose intolerance in male C57Bl/6 mice. Two cohorts of HFSD mice were studied at independent institutes and underwent an oral glucose tolerance test (OGTT) with measures of plasma insulin and free fatty acids (FFA)...
March 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28356401/exposure-to-endocrine-disruptors-during-adulthood-consequences-for-female-fertility
#14
Saniya Rattan, Changqing Zhou, Catheryne Chiang, Sharada Mahalingam, Emily Brehm, Jodie Flaws
Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence...
March 29, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28356400/phospho-erk-and-sex-steroids-in-the-mpoa-involvement-in-male-mouse-sexual-behavior
#15
Arnaud Jean, Anne-Charlotte Trouillet, Njiva Andry Andrianarivelo, Sakina Mhaouty-Kodja, Helene Hardin-Pouzet
This paper aimed to investigate the mechanisms triggering ERK phosphorylation and its functional role in male sexual behaviour. ERK1/2 phosphorylated form was detected in the medial preoptic area of the hypothalamus (mPOA) during the sexual stimulation of naive and sexually experienced males who were sacrificed 5 minutes after the first intromission. This mating-induced ERK phosphorylation was increased in sexually experienced males compared to naive mice. The functional role of the ERK1/2 pathway activation during sexual behaviour was explored with the administration of a MEK inhibitor, SL-327 (30 mg/kg, i...
March 29, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28348116/increased-vimentin-in-human-%C3%AE-and-%C3%AE-cells-in-type-2-diabetes
#16
Maaike Roefs, Françoise Carlotti, Katherine Jones, Hannah Wills, Alexander Hamilton, Michael Verschoor, Joanna Williams Durkin, Laura Garcia-Perez, Melissa Brereton, Laura McCulloch, Marten Engelse, Paul Johnson, Barbara Hansen, Kevin Docherty, Eelco de Koning, Anne Clark
Type 2 diabetes (T2DM) is associated with pancreatic islet dysfunction. Loss of β-cell identity has been implicated via dedifferentiation or conversion to other pancreatic endocrine cell types. How these transitions contribute to the onset and progression of T2DM in vivo is unknown. The aims of this study were to determine the degree of epithelial-to-mesenchymal transition occurring in α and β cells in vivo and to relate this to diabetes-associated (patho)physiological conditions. The proportion of islet cells expressing the mesenchymal marker vimentin was determined by immunohistochemistry and quantitative morphometry in specimens of pancreas from human donors with (T2DM, n=28) and without diabetes (ND, n=38), and in non-human primates at different stages of the diabetic syndrome; normoglycaemic (ND, n=4), obese, hyperinsulinaemic (HI, n=4) and hyperglycaemic (DM, n=8)...
March 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28348115/decrease-in-ins-glut2-lo-%C3%AE-cells-with-advancing-age-in-mouse-and-human-pancreas
#17
Christine A Beamish, Sofia Mehta, Brenda J Strutt, Subrata Chakrabarti, Manami Hara, David J Hill
The presence and location of resident pancreatic β-cell progenitors is controversial. A subpopulation of insulin-expressing but glucose transporter-2-low (Ins+Glut2LO) cells may represent multipotent pancreatic progenitors in adult mouse and human islets, and in mice are enriched in small, extra-islet β-cell clusters (<5 β-cells). Here, we sought to identify and compare the ontogeny of these cells in mouse and human pancreata throughout life. Mouse pancreata were collected at postnatal days (d) 7, 14, 21, 28, and at 3, 6, 12, and 18 months of age, and in the first 28 days after β-cell mass depletion following Streptozotocin (STZ) administration...
March 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28348114/mineralocorticoid-receptor-mutations
#18
Maria-Christina Zennaro, Fabio Luiz Fernandes-Rosa
Aldosterone and the mineralocorticoid receptor (MR) are key elements for maintaining fluid and electrolyte homeostasis as well as regulation of blood pressure. Loss of function mutations of the MR are responsible for renal pseudohypoaldosteronism type 1 (PHA1), a rare disease of mineralocorticoid resistance presenting in the newborn with weight loss, failure to thrive, vomiting and dehydration, associated with hyperkalemia and metabolic acidosis, despite extremely elevated levels of plasma renin and aldosterone...
March 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28348113/nongenomic-effects-via-the-mineralocorticoid-receptor
#19
Stefanie Ruhs, Alexander Nolze, Ralf Hübschmann, Claudia Grossmann
The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and classically functions as a ligand-dependent transcription factor. It is involved in water-electrolyte homeostasis and blood pressure regulation but independently from these effects also furthers inflammation, fibrosis, hypertrophy and remodeling in cardiovascular tissues. Next to genomic effects, aldosterone elicits very rapid actions within minutes that do not require transcription or translation and that occur both in classical MR epithelial target organs like kidney and colon but also in nonepithelial tissues with special pathophysiological relevance like heart and vasculature and adipose tissue...
March 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28348112/hypophysectomy-abolishes-rhythms-in-rat-thyroid-hormones-but-not-in-the-thyroid-clock
#20
Jan Fahrenkrug, Birgitte Georg, Jens Hannibal, Henrik Løvendahl Jørgensen
The endocrine body rhythms including the hypothalamic-pituitary-thyroid axis seem to be regulated by the circadian timing system, and daily rhythmicity of circulating thyroid stimulating hormone (TSH) is well-established. The circadian rhythms are generated by endogenous clocks in the central brain oscillator located in the hypothalamic suprachiasmatic nucleus (SCN) as well as multiple peripheral clocks, but information on the existence and function of a thyroid clock is limited. The molecular machinery in all clock cells is composed of a number of clock genes and their gene products connected by autoregulatory feedback loops...
March 27, 2017: Journal of Endocrinology
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